Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	thioredoxin-dependent peroxiredoxin activity	PRDX1 PRDX2	1.97e-04	7	62	2	GO:0140824
GeneOntologyMolecularFunction	thioredoxin peroxidase activity	PRDX1 PRDX2	1.97e-04	7	62	2	GO:0008379
GeneOntologyMolecularFunction	peroxiredoxin activity	PRDX1 PRDX2	3.37e-04	9	62	2	GO:0051920
GeneOntologyBiologicalProcess	cellular response to oxygen radical	PARP1 PRDX1 PRDX2	5.80e-05	26	60	3	GO:0071450
GeneOntologyBiologicalProcess	cellular response to superoxide	PARP1 PRDX1 PRDX2	5.80e-05	26	60	3	GO:0071451
GeneOntologyBiologicalProcess	response to superoxide	PARP1 PRDX1 PRDX2	8.10e-05	29	60	3	GO:0000303
GeneOntologyBiologicalProcess	response to oxygen radical	PARP1 PRDX1 PRDX2	8.98e-05	30	60	3	GO:0000305
Domain	Peroxiredoxin_AhpC-typ	PRDX1 PRDX2	3.04e-05	3	60	2	IPR024706
Domain	1-cysPrx_C	PRDX1 PRDX2	1.01e-04	5	60	2	PF10417
Domain	Peroxiredoxin_C	PRDX1 PRDX2	1.01e-04	5	60	2	IPR019479
Domain	AhpC/TSA	PRDX1 PRDX2	2.11e-04	7	60	2	IPR000866
Domain	AhpC-TSA	PRDX1 PRDX2	2.11e-04	7	60	2	PF00578
Domain	Cadherin_tail	PCDHA9 PCDHA13 PCDHA12	2.27e-04	37	60	3	PF15974
Domain	Cadherin_CBD	PCDHA9 PCDHA13 PCDHA12	2.27e-04	37	60	3	IPR031904
Domain	Plexin_cytopl	PLXNC1 PLXNA2	3.60e-04	9	60	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNC1 PLXNA2	3.60e-04	9	60	2	IPR013548
Domain	Plexin	PLXNC1 PLXNA2	3.60e-04	9	60	2	IPR031148
Domain	MATH/TRAF_dom	MEP1B TRAF1	6.56e-04	12	60	2	IPR002083
Domain	MATH	MEP1B TRAF1	6.56e-04	12	60	2	PS50144
Domain	MATH	MEP1B TRAF1	6.56e-04	12	60	2	SM00061
Domain	MATH	MEP1B TRAF1	6.56e-04	12	60	2	PF00917
Domain	UBQ-conjugating_enzyme/RWD	UBE2R2 DHX57 CDC34	6.59e-04	53	60	3	IPR016135
Domain	-	MEP1B TRAF1	9.01e-04	14	60	2	2.60.210.10
Domain	UDENN	SBF2 DENND4C	1.18e-03	16	60	2	PS50946
Domain	DDENN	SBF2 DENND4C	1.18e-03	16	60	2	PS50947
Domain	DENN	SBF2 DENND4C	1.18e-03	16	60	2	SM00799
Domain	dDENN	SBF2 DENND4C	1.18e-03	16	60	2	SM00801
Domain	DENN	SBF2 DENND4C	1.18e-03	16	60	2	PF02141
Domain	dDENN_dom	SBF2 DENND4C	1.18e-03	16	60	2	IPR005112
Domain	uDENN_dom	SBF2 DENND4C	1.18e-03	16	60	2	IPR005113
Domain	dDENN	SBF2 DENND4C	1.18e-03	16	60	2	PF03455
Domain	DENN	SBF2 DENND4C	1.18e-03	16	60	2	PS50211
Domain	DENN_dom	SBF2 DENND4C	1.18e-03	16	60	2	IPR001194
Domain	Cadherin_2	PCDHA9 PCDHA13 PCDHA12	1.19e-03	65	60	3	PF08266
Domain	Cadherin_N	PCDHA9 PCDHA13 PCDHA12	1.19e-03	65	60	3	IPR013164
Domain	DEAD/DEAH_box_helicase_dom	DDX47 DHX57 DICER1	1.67e-03	73	60	3	IPR011545
Domain	DEAD	DDX47 DHX57 DICER1	1.67e-03	73	60	3	PF00270
Domain	TRAF-like	MEP1B TRAF1	2.68e-03	24	60	2	IPR008974
Domain	UBQ-conjugating_AS	UBE2R2 CDC34	2.90e-03	25	60	2	IPR023313
Domain	IPT	PLXNC1 PLXNA2	3.38e-03	27	60	2	SM00429
Domain	ZINC_PROTEASE	MEP1B NLN NPEPPS	3.86e-03	98	60	3	PS00142
Domain	TIG	PLXNC1 PLXNA2	4.44e-03	31	60	2	PF01833
Domain	Sema	PLXNC1 PLXNA2	4.44e-03	31	60	2	SM00630
Domain	Semap_dom	PLXNC1 PLXNA2	4.44e-03	31	60	2	IPR001627
Domain	Sema	PLXNC1 PLXNA2	4.44e-03	31	60	2	PF01403
Domain	SEMA	PLXNC1 PLXNA2	4.44e-03	31	60	2	PS51004
Domain	PSI	PLXNC1 PLXNA2	4.73e-03	32	60	2	PF01437
Domain	IPT	PLXNC1 PLXNA2	4.73e-03	32	60	2	IPR002909
Domain	Plexin_repeat	PLXNC1 PLXNA2	4.73e-03	32	60	2	IPR002165
Domain	Helicase_C	DDX47 DHX57 DICER1	4.94e-03	107	60	3	PF00271
Domain	HELICc	DDX47 DHX57 DICER1	4.94e-03	107	60	3	SM00490
Domain	Helicase_C	DDX47 DHX57 DICER1	5.07e-03	108	60	3	IPR001650
Domain	HELICASE_CTER	DDX47 DHX57 DICER1	5.20e-03	109	60	3	PS51194
Domain	HELICASE_ATP_BIND_1	DDX47 DHX57 DICER1	5.20e-03	109	60	3	PS51192
Domain	Cadherin_CS	PCDHA9 PCDHA13 PCDHA12	5.20e-03	109	60	3	IPR020894
Domain	DEXDc	DDX47 DHX57 DICER1	5.20e-03	109	60	3	SM00487
Domain	Helicase_ATP-bd	DDX47 DHX57 DICER1	5.33e-03	110	60	3	IPR014001
Domain	CADHERIN_1	PCDHA9 PCDHA13 PCDHA12	5.74e-03	113	60	3	PS00232
Domain	Cadherin	PCDHA9 PCDHA13 PCDHA12	5.74e-03	113	60	3	PF00028
Domain	CADHERIN_2	PCDHA9 PCDHA13 PCDHA12	5.89e-03	114	60	3	PS50268
Domain	-	PCDHA9 PCDHA13 PCDHA12	5.89e-03	114	60	3	2.60.40.60
Domain	CA	PCDHA9 PCDHA13 PCDHA12	6.03e-03	115	60	3	SM00112
Domain	Cadherin-like	PCDHA9 PCDHA13 PCDHA12	6.18e-03	116	60	3	IPR015919
Pubmed	Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.	POLE PRDX1 PRDX2	6.42e-07	10	62	3	17141802
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA9 PCDHA13 PCDHA12	8.81e-07	11	62	3	9655502
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA9 PCDHA13 PCDHA12	2.42e-06	15	62	3	15640798
Pubmed	Overexpression of peroxiredoxin in human breast cancer.	PRDX1 PRDX2	3.13e-06	2	62	2	11497302
Pubmed	Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.	PRDX1 PRDX2	3.13e-06	2	62	2	26636537
Pubmed	Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway.	PRDX1 PRDX2	3.13e-06	2	62	2	32705184
Pubmed	Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.	PRDX1 PRDX2	3.13e-06	2	62	2	23101509
Pubmed	Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells.	PRDX1 PRDX2	3.13e-06	2	62	2	24715692
Pubmed	Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage.	PRDX1 PRDX2	3.13e-06	2	62	2	24152995
Pubmed	Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.	PRDX1 PRDX2	3.13e-06	2	62	2	28348082
Pubmed	Human Peroxiredoxins 1 and 2 and Their Interacting Protein Partners; Through Structure Toward Functions of Biological Complexes.	PRDX1 PRDX2	3.13e-06	2	62	2	26548861
Pubmed	Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress.	PRDX1 PRDX2	3.13e-06	2	62	2	12853451
Pubmed	Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli.	PRDX1 PRDX2	3.13e-06	2	62	2	31026770
Pubmed	Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment.	PRDX1 PRDX2	3.13e-06	2	62	2	28314261
Pubmed	HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.	PRDX1 PRDX2	3.13e-06	2	62	2	12421812
Pubmed	Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.	PRDX1 PRDX2	3.13e-06	2	62	2	22902630
Pubmed	Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.	PRDX1 PRDX2	3.13e-06	2	62	2	29884768
Pubmed	Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes.	PRDX1 PRDX2	3.13e-06	2	62	2	29503398
Pubmed	Peroxiredoxin I and II are up-regulated during differentiation of epidermal keratinocytes.	PRDX1 PRDX2	3.13e-06	2	62	2	15864612
Pubmed	Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast.	PRDX1 PRDX2	3.13e-06	2	62	2	31580947
Pubmed	Differential parameters between cytosolic 2-Cys peroxiredoxins, PRDX1 and PRDX2.	PRDX1 PRDX2	3.13e-06	2	62	2	30284335
Pubmed	Novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: Nalpha-terminal acetylation of human peroxiredoxin II.	PRDX1 PRDX2	3.13e-06	2	62	2	19286652
Pubmed	Peroxiredoxin expression and redox status in neutrophils and HL-60 cells.	PRDX1 PRDX2	3.13e-06	2	62	2	30862546
Pubmed	Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells.	PRDX1 PRDX2	3.13e-06	2	62	2	12107731
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA9 PCDHA13 PCDHA12	3.60e-06	17	62	3	29911975
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	UBE2R2 WARS1 POLE SBF2 CDC34 DENND4C	3.72e-06	232	62	6	25515538
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA9 PCDHA13 PCDHA12	4.32e-06	18	62	3	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA9 PCDHA13 PCDHA12	4.32e-06	18	62	3	10662547
Pubmed	Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells.	PRDX1 PRDX2	9.37e-06	3	62	2	22099303
Pubmed	Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation.	PRDX1 PRDX2	9.37e-06	3	62	2	11986303
Pubmed	Identification of two novel PCDHA9 mutations associated with Hirschsprung's disease.	PCDHA9 PCDHA12	9.37e-06	3	62	2	29477871
Pubmed	Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.	PRDX1 PRDX2	9.37e-06	3	62	2	8026862
Pubmed	Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury.	PARP1 PRDX2	9.37e-06	3	62	2	23429506
Pubmed	Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila.	PRDX1 PRDX2	9.37e-06	3	62	2	10632718
Pubmed	Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.	PRDX1 PRDX2	9.37e-06	3	62	2	22215146
Pubmed	Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2.	PRDX1 PRDX2	9.37e-06	3	62	2	17519234
Pubmed	Structural and biochemical analyses reveal ubiquitin C-terminal hydrolase-L1 as a specific client of the peroxiredoxin II chaperone.	PRDX1 PRDX2	9.37e-06	3	62	2	29339092
Pubmed	Crucial role of peroxiredoxin III in placental antioxidant defense of mice.	PRDX1 PRDX2	9.37e-06	3	62	2	18544346
Pubmed	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.	PRDX1 PRDX2	9.37e-06	3	62	2	28659575
Pubmed	Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate.	PRDX1 PRDX2	9.37e-06	3	62	2	10751410
Pubmed	Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.	PRDX1 PRDX2	9.37e-06	3	62	2	11771746
Pubmed	DICER and ZRF1 contribute to chromatin decondensation during nucleotide excision repair.	PARP1 DICER1	9.37e-06	3	62	2	28402505
Pubmed	HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.	PRDX1 PRDX2	9.37e-06	3	62	2	18606987
Pubmed	Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.	PARP1 NIT2	9.37e-06	3	62	2	25738796
Pubmed	Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.	PRDX1 PRDX2	9.37e-06	3	62	2	22537621
Pubmed	Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.	PRDX1 PRDX2	9.37e-06	3	62	2	31470801
Pubmed	Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.	PRDX1 PRDX2	9.37e-06	3	62	2	11904290
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA9 PCDHA13 PCDHA12	1.06e-05	24	62	3	24698270
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA9 PCDHA13 PCDHA12	1.71e-05	28	62	3	15347688
Pubmed	A context-dependent and disordered ubiquitin-binding motif.	UBE2R2 CDC34	1.87e-05	4	62	2	35974206
Pubmed	Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes.	PARP1 CD207	1.87e-05	4	62	2	20713892
Pubmed	CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability.	PARP1 PRDX2	1.87e-05	4	62	2	34384442
Pubmed	Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.	PRDX1 PRDX2	1.87e-05	4	62	2	15105503
Pubmed	Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.	PRDX1 PRDX2	1.87e-05	4	62	2	12080185
Pubmed	Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.	PRDX1 PRDX2	1.87e-05	4	62	2	12650976
Pubmed	Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.	PRDX1 PRDX2	1.87e-05	4	62	2	23113308
Pubmed	The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.	PARP1 DTX3L	1.87e-05	4	62	2	18069692
Pubmed	A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.	UBE2R2 PRDX1 PRDX2 CDC34	1.91e-05	88	62	4	27182664
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	PIK3CB FDPS PRDX1 RNF213 ITIH2	1.94e-05	183	62	5	23956138
Pubmed	Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.	UBE2R2 CDC34	3.12e-05	5	62	2	27044868
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA9 PCDHA12	3.12e-05	5	62	2	34888534
Pubmed	BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.	PARP1 DTX3L	4.67e-05	6	62	2	23230272
Pubmed	Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.	PARP1 WARS1	4.67e-05	6	62	2	22504299
Pubmed	Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice.	PRDX1 PRDX2	4.67e-05	6	62	2	33254076
Pubmed	Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio.	WARS1 GRB14	4.67e-05	6	62	2	23670221
Pubmed	Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.	SETDB1 PARP1	6.53e-05	7	62	2	21983785
Pubmed	Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.	PARP1 POLE	6.53e-05	7	62	2	9563011
Pubmed	Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro.	PRDX1 PRDX2	6.53e-05	7	62	2	10514471
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	DDX47 PARP1 NPEPPS DHX57 CDC34	6.64e-05	237	62	5	29564676
Pubmed	A catalogue of putative HIV-1 protease host cell substrates.	PARP1 NPEPPS PRDX1 PRDX2	7.32e-05	124	62	4	22944692
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNC1 PLXNA2	8.69e-05	8	62	2	15661641
Pubmed	CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.	UBE2R2 CDC34	8.69e-05	8	62	2	12037680
Pubmed	DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.	PARP1 DTX3L	1.12e-04	9	62	2	24886089
Pubmed	PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal.	PRDX1 PRDX2	1.12e-04	9	62	2	30097850
Pubmed	Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death.	PRDX1 PRDX2	1.12e-04	9	62	2	15858817
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DDX47 PARP1 WARS1 FDPS NPEPPS POLE TAF1B PRDX1 DHX57 PRDX2	1.31e-04	1353	62	10	29467282
Pubmed	Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.	UBE2R2 CDC34	1.39e-04	10	62	2	31868589
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA9 PCDHA13 PCDHA12	1.47e-04	57	62	3	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA9 PCDHA13 PCDHA12	1.55e-04	58	62	3	30377227
Pubmed	FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.	PIK3CB CDC34	1.70e-04	11	62	2	23604317
Pubmed	miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation.	DICER1 PLXNA2	1.70e-04	11	62	2	20018673
Pubmed	The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.	DDX47 RALGAPA1 PARP1	1.89e-04	62	62	3	19710015
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA9 PCDHA13	2.04e-04	12	62	2	10612399
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNC1 PLXNA2	2.04e-04	12	62	2	21270798
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	NPEPPS SBF2 DHX57 DICER1	2.30e-04	167	62	4	25659891
Pubmed	The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.	PRDX1 PRDX2	2.41e-04	13	62	2	19766572
Pubmed	Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.	PRDX1 PRDX2	2.41e-04	13	62	2	25975898
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNC1 PLXNA2	2.41e-04	13	62	2	10520995
Pubmed	Ubiquitination of STING at lysine 224 controls IRF3 activation.	UBE2R2 CDC34	2.41e-04	13	62	2	28763789
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA9 PCDHA13 PCDHA12	2.49e-04	68	62	3	11230163
Pubmed	Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.	PIK3CB DICER1	2.81e-04	14	62	2	18988856
Pubmed	Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2.	PRDX1 PRDX2	2.81e-04	14	62	2	29720484
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA9 PCDHA13 PCDHA12	2.95e-04	72	62	3	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA9 PCDHA13 PCDHA12	3.20e-04	74	62	3	10817752
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	RALGAPA1 RIDA SETDB1 TTLL4 RNF213 DICER1 DENND4C	3.23e-04	733	62	7	34672954
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA9 PCDHA13 PCDHA12	3.32e-04	75	62	3	15372022
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA9 PCDHA13 PCDHA12	3.59e-04	77	62	3	10835267
Pubmed	Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.	PLXNC1 PLXNA2	3.69e-04	16	62	2	17356169
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PCDHA9 KSR2 PCDHA13 PCDHA12	3.99e-04	193	62	4	22589738
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA9 PCDHA13 PCDHA12	4.02e-04	80	62	3	10716726
Cytoband	12q23.3	EID3 PLXNC1 TMEM119	1.49e-05	35	62	3	12q23.3
Cytoband	5q31	PCDHA9 PCDHA13 PCDHA12	5.20e-04	115	62	3	5q31
GeneFamily	Peroxiredoxins	PRDX1 PRDX2	8.24e-05	6	43	2	953
GeneFamily	Plexins	PLXNC1 PLXNA2	1.97e-04	9	43	2	683
GeneFamily	Clustered protocadherins	PCDHA9 PCDHA13 PCDHA12	4.72e-04	64	43	3	20
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	SBF2 DENND4C	1.60e-03	25	43	2	504
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2R2 CDC34	4.27e-03	41	43	2	102
Disease	1,5 anhydroglucitol measurement	PCDHA9 PCDHA13 PCDHA12	2.67e-05	29	59	3	EFO_0008009
Disease	visceral adipose tissue measurement, body mass index	PCDHA9 KSR2 PCDHA13 PCDHA12	2.83e-05	87	59	4	EFO_0004340, EFO_0004765
Disease	Hypoplastic Left Heart Syndrome	PCDHA9 PCDHA13	3.92e-05	5	59	2	C0152101
Disease	Moyamoya disease	NLN SBF2 RNF213	7.12e-05	40	59	3	MONDO_0016820
Disease	mismatch repair cancer syndrome (is_implicated_in)	POLE TAF1B	2.56e-04	12	59	2	DOID:0112182 (is_implicated_in)
Disease	Asbestosis	PRDX1 PRDX2	3.52e-04	14	59	2	C0003949
Disease	Pulmonary Fibrosis - from Asbestos Exposure	PRDX1 PRDX2	3.52e-04	14	59	2	C2930617
Disease	urinary albumin to creatinine ratio	CYP2G1P HS6ST1 SBF2 PDGFD	4.59e-04	179	59	4	EFO_0007778
Disease	azoospermia (implicated_via_orthology)	UBE2R2 CDC34	1.34e-03	27	59	2	DOID:14227 (implicated_via_orthology)
Disease	prostate cancer (implicated_via_orthology)	MEP1B POLE	1.99e-03	33	59	2	DOID:10283 (implicated_via_orthology)
Disease	Abnormality of refraction	UBE2R2 PCDHA9 KSR2 PCDHA13 PCDHA12 TMEM119	2.22e-03	673	59	6	HP_0000539

Protein segments in the cluster

Peptide	Gene	Start	Entry
NPFLSKVKLIYYYLF	ALG11	226	Q2TAA5
YYIFIPSKFKDTYLV	DDX47	241	Q9H0S4
SYFYKEQPLDLIKNY	ANO5	281	Q75V66
KFVGYPGKYTYLFNE	ANO5	581	Q75V66
AFTPEKLKNAYVLYY	CALCR	136	P30988
FPYSFKPFFCLEKYL	ABCA13	2876	Q86UQ4
PSPEYETFAEYYKTK	DICER1	961	Q9UPY3
YVLKSKLAYYDPHPY	NAP1L2	306	Q9ULW6
PHVPFKLVSTYKNYY	PCDHA9	391	Q9Y5H5
FTKYPKKFYPLEIDY	PARP1	631	P09874
KLKFYYNPNFKRGYP	HSFY1	171	Q96LI6
YKDYFVPQLYSFLKR	ITIH2	931	P19823
YPTEFEFNLYYLKFL	SBF2	1486	Q86WG5
FIAKYQDYTFYELKP	MYO1A	61	Q9UBC5
SIVKYKTAFYSFYLP	FDPS	261	P14324
LPASHYYKYKQQFIF	KSR2	561	Q6VAB6
YYKYKQQFIFPDVVP	KSR2	566	Q6VAB6
YFRKYPDTPVSYFEF	EID3	231	Q8N140
YFVAKPGFKIYYSLL	PDGFD	156	Q9GZP0
IYNDTKFIYYPNPTF	PLXNA2	1131	O75051
FYKLVPDPVKNIYIY	PLXNC1	426	O60486
GSRFKVALPYKPYFY	POLE	91	Q07864
AKTLPFYKDYFNVPY	NPEPPSL1	286	A6NEC2
FYKDYFNVPYPLPKI	NPEPPSL1	291	A6NEC2
DFYYFPSVSKLKPEN	MPPED1	166	O15442
SDYKGKYVVLFFYPL	PRDX2	31	P32119
LFPTPDPHYEKKYYF	HS6ST1	56	O60243
ALPMFYVYDSYITKP	MANEA	261	Q5SRI9
LSDYKGKYVVFFFYP	PRDX1	31	Q06830
PHVPFKLVSTYKNYY	PCDHA13	391	Q9Y5I0
LDKNFPKSAFYYDYV	METTL21C	176	Q5VZV1
YVEFMKDNYPPSFKY	FUCA2	86	Q9BTY2
QKSNYFEVPLPYFEY	DTX3L	231	Q8TDB6
FEVPLPYFEYFKYIC	DTX3L	236	Q8TDB6
PYFEYFKYICPDKIN	DTX3L	241	Q8TDB6
YEKYPFFRANIRKYP	CHKA	356	P35790
KDHKYPYQAPLVAFY	DHX57	361	Q6P158
KKVYGAAIQFYEPYS	DENND4C	266	Q5VZ89
DLSPKYSYKYFPRLD	DENND4C	701	Q5VZ89
YFRKNYAKYEFFKNP	GRB14	186	Q14449
YAKYEFFKNPMYFFP	GRB14	191	Q14449
LVYYFSSPSFPKFYN	HCAR1	276	Q9BXC0
PPFYSSKGYAFQIYL	MEP1B	451	Q16820
AKTLPFYKDYFNVPY	NPEPPS	286	P55786
FYKDYFNVPYPLPKI	NPEPPS	291	P55786
PHVPFKLVSTYKNYY	PCDHA12	391	Q9UN75
SFPAVIDYTPYLKYI	RUNDC3B	211	Q96NL0
VLDAYENKKPFYLYT	WARS1	146	P23381
KPLYYSFVDKPVAYK	TAF1B	431	Q53T94
NSPYGAKYFPEYAEK	NIT2	46	Q9NQR4
LHVKFPENKKQPYYY	PIK3CB	491	P42338
VDRKFQPYKPFYYIL	SETDB1	666	Q15047
QPYKPFYYILDITYG	SETDB1	671	Q15047
LKDPKYFRYPDAFYP	CYP2G1P	51	Q6ZSU1
SFEKAKPNIYIYPDF	CCDC54	231	Q8NEL0
YFKGNFYYFSLIPKT	CD207	201	Q9UJ71
DDKYKITLKYPHYFP	NLN	236	Q9BYT8
YKQYFKSNFPARAAY	RIDA	96	P52758
KYIPYKYVIYNGESF	RNF213	446	Q63HN8
GYFKARLKFPIDYPY	CDC34	56	P49427
FSHFKKYYLPYIFPN	RALGAPA1	241	Q6GYQ0
PQYFLYKFPKDVDSV	SIDT1	186	Q9NXL6
PNSVPYCYFKKPEIY	HEATR9	66	A2RTY3
LFSPAFYTAKYGYKL	TRAF1	291	Q13077
PKPLISYIRKFYYYD	SOCS7	541	O14512
PFKQPNYYYKLRNFY	ZBTB49	206	Q6ZSB9
GYFKAHIKFPIDYPY	UBE2R2	56	Q712K3
HKAYEYQDYAPKPYK	ZNF763	131	Q0D2J5
KAYYLTQKIPDQDFY	TTLL4	981	Q14679
AYYPSSFPKKKYVDQ	TMEM119	126	Q4V9L6
QRAKVYYAKFPPDIY	UPRT	216	Q96BW1
GYFTFNLYLKLPKPY	PSG5	136	Q15238