Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-catenin binding	PTPRT PKP3 PKP2	5.95e-05	12	132	3	GO:0045294
GeneOntologyBiologicalProcess	brainstem development	NLGN4Y NLGN4X CNTFR	1.34e-05	8	130	3	GO:0003360
GeneOntologyCellularComponent	symmetric synapse	NLGN4Y NLGN4X IGSF9B	6.57e-05	13	131	3	GO:0032280
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	1.16e-04	3	131	2	GO:0043291
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4Y NLGN4X	2.32e-04	4	131	2	GO:0098983
GeneOntologyCellularComponent	adherens junction	SORBS1 DLL1 LLGL2 LLGL1 HMCN1 PKP3 PKP2	3.86e-04	212	131	7	GO:0005912
MousePheno	decreased kidney cell proliferation	PDGFRB PKHD1 NOS3	2.81e-05	9	99	3	MP:0011441
MousePheno	domed cranium	ERF PHEX TYRP1 LLGL1 CSF1R PKD1	3.02e-05	85	99	6	MP:0000440
MousePheno	abnormal kidney cell proliferation	PDGFRB PKD1 PKHD1 NOS3	3.14e-05	26	99	4	MP:0011439
Domain	Carboxylesterase_B_CS	CES1 NLGN4Y TG NLGN4X	1.43e-06	13	128	4	IPR019819
Domain	CARBOXYLESTERASE_B_2	CES1 NLGN4Y TG NLGN4X	2.00e-06	14	128	4	PS00941
Domain	COesterase	CES1 NLGN4Y TG NLGN4X	2.00e-06	14	128	4	PF00135
Domain	CarbesteraseB	CES1 NLGN4Y TG NLGN4X	2.00e-06	14	128	4	IPR002018
Domain	Rav1p_C	DMXL2 DMXL1	4.66e-05	2	128	2	IPR022033
Domain	NLGN4	NLGN4Y NLGN4X	4.66e-05	2	128	2	IPR030025
Domain	Rav1p_C	DMXL2 DMXL1	4.66e-05	2	128	2	PF12234
Domain	IGc2	PDGFRB CNTN6 TYRO3 CSF1R HMCN1 IGSF9B IGSF1 CNTFR	2.18e-04	235	128	8	SM00408
Domain	Ig_sub2	PDGFRB CNTN6 TYRO3 CSF1R HMCN1 IGSF9B IGSF1 CNTFR	2.18e-04	235	128	8	IPR003598
Domain	LLGL	LLGL2 LLGL1	2.77e-04	4	128	2	PF08366
Domain	Lethal2_giant	LLGL2 LLGL1	2.77e-04	4	128	2	IPR000664
Domain	Tyr_kinase_non-rcpt_Jak/Tyk2	JAK2 JAK3	2.77e-04	4	128	2	IPR016251
Domain	LLGL2	LLGL2 LLGL1	2.77e-04	4	128	2	IPR013577
Domain	Tyr_kinase_cat_dom	PDGFRB JAK2 TYRO3 JAK3 CSF1R	3.48e-04	88	128	5	IPR020635
Domain	TyrKc	PDGFRB JAK2 TYRO3 JAK3 CSF1R	3.48e-04	88	128	5	SM00219
Domain	FERM_domain	FRMD7 JAK2 JAK3 EPB41L1	3.51e-04	49	128	4	IPR000299
Domain	FERM_1	FRMD7 JAK2 JAK3 EPB41L1	3.80e-04	50	128	4	PS00660
Domain	FERM_2	FRMD7 JAK2 JAK3 EPB41L1	3.80e-04	50	128	4	PS00661
Domain	FERM_3	FRMD7 JAK2 JAK3 EPB41L1	3.80e-04	50	128	4	PS50057
Domain	Band_41_domain	FRMD7 JAK2 JAK3 EPB41L1	3.80e-04	50	128	4	IPR019749
Domain	B41	FRMD7 JAK2 JAK3 EPB41L1	3.80e-04	50	128	4	SM00295
Domain	HEMATOPO_REC_L_F3	EBI3 CNTFR	4.60e-04	5	128	2	PS01354
Domain	Nlgn	NLGN4Y NLGN4X	4.60e-04	5	128	2	IPR000460
Domain	Hematopoietin_rcpt_L_F3_CS	EBI3 CNTFR	4.60e-04	5	128	2	IPR003530
Domain	PROTEIN_KINASE_TYR	PDGFRB JAK2 TYRO3 JAK3 CSF1R	5.44e-04	97	128	5	PS00109
Domain	Tyr_kinase_AS	PDGFRB JAK2 TYRO3 JAK3 CSF1R	5.44e-04	97	128	5	IPR008266
Domain	Tyr_kinase_CSF1/PDGF_rcpt	PDGFRB CSF1R	6.87e-04	6	128	2	IPR016243
Domain	fn3	PTPRT CNTN6 TYRO3 EBI3 IGSF9B CNTFR	8.81e-04	162	128	6	PF00041
Domain	Plakophilin/d_Catenin	PKP3 PKP2	9.57e-04	7	128	2	IPR028435
Domain	Tyr_kinase_rcpt_3_CS	PDGFRB CSF1R	1.27e-03	8	128	2	IPR001824
Domain	RECEPTOR_TYR_KIN_III	PDGFRB CSF1R	1.27e-03	8	128	2	PS00240
Domain	-	AADACL4 CES1 NLGN4Y TG NLGN4X	1.37e-03	119	128	5	3.40.50.1820
Domain	AB_hydrolase	AADACL4 CES1 NLGN4Y TG NLGN4X	1.37e-03	119	128	5	IPR029058
Domain	MAGE	MAGEB2 MAGEH1 MAGED2	1.61e-03	34	128	3	SM01373
Domain	FN3	PTPRT CNTN6 TYRO3 EBI3 IGSF9B CNTFR	1.74e-03	185	128	6	SM00060
Domain	EGF	CUBN DLL1 PTGS1 STAB1 HMCN1	1.76e-03	126	128	5	PF00008
Domain	MAGE	MAGEB2 MAGEH1 MAGED2	1.90e-03	36	128	3	PS50838
Domain	MHD_dom	MAGEB2 MAGEH1 MAGED2	1.90e-03	36	128	3	IPR002190
Domain	MAGE	MAGEB2 MAGEH1 MAGED2	1.90e-03	36	128	3	PF01454
Domain	Pkinase_Tyr	PDGFRB JAK2 TYRO3 JAK3 CSF1R	1.95e-03	129	128	5	PF07714
Domain	ig	PDGFRB TYRO3 CSF1R HMCN1 IGSF1 CNTFR	1.99e-03	190	128	6	PF00047
Domain	Immunoglobulin	PDGFRB TYRO3 CSF1R HMCN1 IGSF1 CNTFR	1.99e-03	190	128	6	IPR013151
Domain	An_peroxidase	PTGS1 LPO	2.02e-03	10	128	2	PF03098
Domain	Haem_peroxidase_animal	PTGS1 LPO	2.02e-03	10	128	2	IPR019791
Domain	Haem_peroxidase	PTGS1 LPO	2.02e-03	10	128	2	IPR010255
Domain	PEROXIDASE_3	PTGS1 LPO	2.02e-03	10	128	2	PS50292
Domain	-	PTGS1 LPO	2.02e-03	10	128	2	1.10.640.10
Domain	GFP-like	STAB1 HMCN1	2.46e-03	11	128	2	IPR023413
Domain	-	STAB1 HMCN1	2.46e-03	11	128	2	2.40.155.10
Domain	IG	PDGFRB PTPRT CNTN6 TYRO3 CSF1R HMCN1 IGSF9B IGSF1 CNTFR	2.48e-03	421	128	9	SM00409
Domain	Ig_sub	PDGFRB PTPRT CNTN6 TYRO3 CSF1R HMCN1 IGSF9B IGSF1 CNTFR	2.48e-03	421	128	9	IPR003599
Domain	FN3	PTPRT CNTN6 TYRO3 EBI3 IGSF9B CNTFR	2.51e-03	199	128	6	PS50853
Domain	Ser-Thr/Tyr_kinase_cat_dom	PDGFRB JAK2 TYRO3 JAK3 CSF1R	2.62e-03	138	128	5	IPR001245
Domain	EGF_dom	CUBN STAB1	2.94e-03	12	128	2	IPR024731
Domain	EGF_3	CUBN STAB1	2.94e-03	12	128	2	PF12947
Domain	FN3_dom	PTPRT CNTN6 TYRO3 EBI3 IGSF9B CNTFR	3.20e-03	209	128	6	IPR003961
Domain	FA	FRMD7 EPB41L1	3.46e-03	13	128	2	PF08736
Domain	FERM-adjacent	FRMD7 EPB41L1	3.46e-03	13	128	2	IPR014847
Domain	FA	FRMD7 EPB41L1	3.46e-03	13	128	2	SM01195
Domain	Growth_fac_rcpt_	LAMC1 CUBN DLL1 STAB1 HMCN1	4.43e-03	156	128	5	IPR009030
Domain	-	MRC1 CLEC4M STAB1 PKD1	4.46e-03	97	128	4	3.10.100.10
Domain	FERM_central	FRMD7 JAK2 EPB41L1	4.60e-03	49	128	3	IPR019748
Domain	C-type_lectin-like/link	MRC1 CLEC4M STAB1 PKD1	4.80e-03	99	128	4	IPR016186
Domain	EGF	LAMC1 CUBN DLL1 PTGS1 STAB1 HMCN1	5.65e-03	235	128	6	SM00181
Domain	Glycoside_hydrolase_SF	GLB1L3 IDUA MGAM2	5.74e-03	53	128	3	IPR017853
Domain	-	PDGFRB PTPRT CNTN6 TYRO3 CSF1R HMCN1 EBI3 PKHD1 IGSF9B IGSF1 CNTFR	5.92e-03	663	128	11	2.60.40.10
Domain	C345C	PCOLCE2 C5	5.93e-03	17	128	2	SM00643
Domain	CTDL_fold	MRC1 CLEC4M STAB1 PKD1	6.31e-03	107	128	4	IPR016187
Domain	IG_LIKE	PDGFRB PTPRT CNTN6 TYRO3 CSF1R HMCN1 IGSF9B IGSF1 CNTFR	6.74e-03	491	128	9	PS50835
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DMXL2 MIA3 GNL3L ERF ELP1 PWP1 ARNT CCDC88A LLGL2 LLGL1 XRN1 GALNT6 NMT1 EPB41L1 RHOT1	3.56e-08	650	134	15	38777146
Pubmed	PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.	JAK2 PKD1 CDK2	4.62e-06	9	134	3	12007403
Pubmed	Genetic mutations associated with cigarette smoking in pancreatic cancer.	MAP2K4 PTPRT JAK2 CSF1R BRCA2	4.63e-06	63	134	5	19351817
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	PDGFRB JAK2 TYRO3 CSF1R	6.97e-06	32	134	4	7542761
Pubmed	Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.	JAK2 JAK3	1.47e-05	2	134	2	29082853
Pubmed	The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration.	LLGL2 LLGL1	1.47e-05	2	134	2	22219375
Pubmed	Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.	LLGL2 LLGL1	1.47e-05	2	134	2	23110097
Pubmed	alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice.	CACNA1G NOS3	1.47e-05	2	134	2	19920353
Pubmed	Esterase-1: developmental expression in the mouse and distribution of related proteins in other species.	CES1 TG	1.47e-05	2	134	2	1632635
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4Y NLGN4X	1.47e-05	2	134	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4Y NLGN4X	1.47e-05	2	134	2	24855039
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4Y NLGN4X	1.47e-05	2	134	2	37001827
Pubmed	Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.	PDGFRB CSF1R	1.47e-05	2	134	2	2846185
Pubmed	The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.	PKD1 PKHD1	1.47e-05	2	134	2	11919560
Pubmed	Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer.	PKP3 PKP2	1.47e-05	2	134	2	22119253
Pubmed	Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro.	CES1P1 CES1	1.47e-05	2	134	2	17264798
Pubmed	Fine mapping of murine asthma quantitative trait loci and analyses of Ptgs1 and Mrc1 as positional candidate genes.	MRC1 PTGS1	1.47e-05	2	134	2	17454003
Pubmed	Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling.	ABCA1 NOS3	1.47e-05	2	134	2	36335301
Pubmed	Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase.	NMT1 NOS3	1.47e-05	2	134	2	7512951
Pubmed	Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.	CES1P1 CES1	1.47e-05	2	134	2	26871237
Pubmed	Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer.	MAP2K4 BRCA2	1.47e-05	2	134	2	23299404
Pubmed	HIF-1beta determines ABCA1 expression under hypoxia in human macrophages.	ABCA1 ARNT	1.47e-05	2	134	2	19828131
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4Y NLGN4X	1.47e-05	2	134	2	18434543
Pubmed	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.	PTPRT JAK2	1.47e-05	2	134	2	31844068
Pubmed	Pathogenicity analysis of novel variations in Chinese Han patients with polycystic kidney disease.	PKD1 PKHD1	1.47e-05	2	134	2	28578020
Pubmed	Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis.	JAK2 PKD1	1.47e-05	2	134	2	30872773
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4Y NLGN4X	1.47e-05	2	134	2	37080762
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4Y NLGN4X	1.47e-05	2	134	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4Y NLGN4X	1.47e-05	2	134	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4Y NLGN4X	1.47e-05	2	134	2	24104404
Pubmed	Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.	PTGS1 NOS3	1.47e-05	2	134	2	15699263
Pubmed	CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas.	PDGFRB CSF1R	1.47e-05	2	134	2	19377443
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4Y NLGN4X	1.47e-05	2	134	2	32243781
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4Y NLGN4X	1.47e-05	2	134	2	22989184
Pubmed	Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.	JAK2 JAK3	1.47e-05	2	134	2	20979137
Pubmed	Genes encoding the platelet-derived growth factor (PDGF) receptor and colony-stimulating factor 1 (CSF-1) receptor are physically associated in mice as in humans.	PDGFRB CSF1R	1.47e-05	2	134	2	1660841
Pubmed	The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.	JAK2 JAK3	1.47e-05	2	134	2	12351625
Pubmed	The protein tyrosine kinase family of the human genome.	PDGFRB JAK2 TYRO3 JAK3 CSF1R	1.80e-05	83	134	5	11114734
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	JAK2 JAK3 LLGL2 LLGL1 MAGED2 AIFM1 PKP3 PKP2 CDK2	2.70e-05	401	134	9	25852190
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	PTPRT CNTN6 TYRO3 CSF1R HMCN1 IGSF1	4.09e-05	162	134	6	25826454
Pubmed	An overview of the MAGE gene family with the identification of all human members of the family.	MAGEB2 MAGEH1 MAGED2	4.37e-05	18	134	3	11454705
Pubmed	Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.	JAK2 JAK3	4.41e-05	3	134	2	21537335
Pubmed	Characterization of PKD protein-positive exosome-like vesicles.	PKD1 PKHD1	4.41e-05	3	134	2	19158352
Pubmed	JAK and MPL mutations in myeloid malignancies.	JAK2 JAK3	4.41e-05	3	134	2	18297515
Pubmed	Structural organization and chromosomal mapping of JAK3 locus.	JAK2 JAK3	4.41e-05	3	134	2	8934548
Pubmed	Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.	JAK2 JAK3	4.41e-05	3	134	2	15121872
Pubmed	Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers.	PKP3 PKP2	4.41e-05	3	134	2	21947748
Pubmed	ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.	ABCA1 JAK2	4.41e-05	3	134	2	18776170
Pubmed	CXCL12 signaling is independent of Jak2 and Jak3.	JAK2 JAK3	4.41e-05	3	134	2	15611059
Pubmed	Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro.	JAK2 JAK3	4.41e-05	3	134	2	27383175
Pubmed	Age-associated inflammation inhibits epidermal stem cell function.	JAK2 JAK3	4.41e-05	3	134	2	22972935
Pubmed	ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway.	ABCA1 NOS3	4.41e-05	3	134	2	32428234
Pubmed	Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms.	CES1P1 CES1	4.41e-05	3	134	2	10452915
Pubmed	Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.	ABCA1 JAK2	4.41e-05	3	134	2	18239666
Pubmed	Genetic Variants and Their Associations to Type 2 Diabetes Mellitus Complications in the United Arab Emirates.	ABCA1 NOS3	4.41e-05	3	134	2	35069435
Pubmed	Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA.	PKP3 PKP2	4.41e-05	3	134	2	20613778
Pubmed	YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.	PDGFRB JAK2	4.41e-05	3	134	2	12551917
Pubmed	Plakophilin 3--a novel cell-type-specific desmosomal plaque protein.	PKP3 PKP2	4.41e-05	3	134	2	10374265
Pubmed	Jak3 maps to chromosome 8.	JAK2 JAK3	4.41e-05	3	134	2	8662243
Pubmed	Vital function of PRELI and essential requirement of its LEA motif.	OPA1 AIFM1	4.41e-05	3	134	2	21364629
Pubmed	Desmocollin-2 alone forms functional desmosomal plaques, with the plaque formation requiring the juxtamembrane region and plakophilins.	PKP3 PKP2	4.41e-05	3	134	2	25972099
Pubmed	Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.	CES1P1 CES1	4.41e-05	3	134	2	20195289
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4Y NLGN4X	4.41e-05	3	134	2	32011705
Pubmed	Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs).	PKD1 PKHD1	4.41e-05	3	134	2	32001768
Pubmed	Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.	JAK2 JAK3	4.41e-05	3	134	2	27905037
Pubmed	JAK mutations in high-risk childhood acute lymphoblastic leukemia.	JAK2 JAK3	4.41e-05	3	134	2	19470474
Pubmed	Expression of polycystins and fibrocystin on primary cilia of lung cells.	PKD1 PKHD1	4.41e-05	3	134	2	25367197
Pubmed	Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells.	PTGS1 NOS3	4.41e-05	3	134	2	28244682
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4Y NLGN4X	4.41e-05	3	134	2	18628683
Pubmed	Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations.	JAK2 PKD1	4.41e-05	3	134	2	24416790
Pubmed	Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis.	PKD1 PKHD1	4.41e-05	3	134	2	37845212
Pubmed	Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.	GFI1 CSF1R	4.41e-05	3	134	2	18328744
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4Y NLGN4X	4.41e-05	3	134	2	21282647
Pubmed	The Janus kinase family of protein tyrosine kinases and their role in signaling.	JAK2 JAK3	4.41e-05	3	134	2	10526570
Pubmed	Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.	CLEC4M STAB1	4.41e-05	3	134	2	17006978
Pubmed	Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.	TCIRG1 PHEX	4.41e-05	3	134	2	23174213
Pubmed	Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.	JAK2 JAK3	4.41e-05	3	134	2	32001089
Pubmed	Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.	TCAF1 RBM25 CCDC88A	5.18e-05	19	134	3	34467244
Pubmed	Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.	ABCA1 TYRP1 C5 CNTFR	5.33e-05	53	134	4	7774911
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	MRC1 MAGEB2 ABCA1 MAGEH1 BIRC7 MAGEA13P PQBP1 GSPT2 AIFM1 NYNRIN AMMECR1	6.37e-05	674	134	11	37196079
Pubmed	Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.	CUBN PKD1 PKHD1	7.07e-05	21	134	3	27591083
Pubmed	A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.	CES1 TYRP1 C5	7.07e-05	21	134	3	4042679
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MAP2K4 MAGEB2 MICOS13 RETSAT OGDH PWP1 LLGL1 CLN6 TXNDC16 CNOT2 RHOT1	7.45e-05	686	134	11	28380382
Pubmed	Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.	LLGL2 LLGL1	8.80e-05	4	134	2	12725730
Pubmed	Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway.	ABCA1 JAK2	8.80e-05	4	134	2	25194807
Pubmed	Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.	PDGFRB JAK2	8.80e-05	4	134	2	8657151
Pubmed	Regulation of the Jak/STAT signalling pathway.	JAK2 JAK3	8.80e-05	4	134	2	8593242
Pubmed	Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.	JAK2 JAK3	8.80e-05	4	134	2	24843152
Pubmed	Three distinct signalling responses by murine fibroblasts to genotoxic stress.	JAK2 JAK3	8.80e-05	4	134	2	8918879
Pubmed	A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.	PKD1 NOS3	8.80e-05	4	134	2	20554900
Pubmed	Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells.	JAK2 JAK3	8.80e-05	4	134	2	19361784
Pubmed	Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1.	LAMC1 HMCN1	8.80e-05	4	134	2	15370542
Pubmed	Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.	CES1P1 CES1	8.80e-05	4	134	2	18794728
Pubmed	Cilia and polycystic kidney disease.	PKD1 PKHD1	8.80e-05	4	134	2	32475690
Pubmed	Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis.	JAK2 PKD1	8.80e-05	4	134	2	27699453
Pubmed	Loss of oriented cell division does not initiate cyst formation.	PKD1 PKHD1	8.80e-05	4	134	2	19959710
Pubmed	Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria.	PDGFRB CSF1R	8.80e-05	4	134	2	11796577
Pubmed	RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.	JAK2 RHEX	8.80e-05	4	134	2	25092874
Pubmed	Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.	LAMC1 HMCN1	8.80e-05	4	134	2	36007682
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4Y NLGN4X	8.80e-05	4	134	2	12669065
Cytoband	Ensembl 112 genes in cytogenetic band chrXq26	INTS6L FRMD7 MAGEA13P AIFM1 IGSF1	1.53e-04	171	134	5	chrXq26
Cytoband	11p14.2	SLC5A12 ANO3	1.76e-04	7	134	2	11p14.2
Cytoband	12p11	MRPS35 PKP2	3.00e-04	9	134	2	12p11
GeneFamily	Immunoglobulin like domain containing	PDGFRB PTPRT TYRO3 CSF1R IGSF9B IGSF1 CNTFR	1.97e-05	193	78	7	594
GeneFamily	MAGE family	MAGEB2 MAGEH1 MAGEA13P MAGED2	2.60e-05	40	78	4	1136
GeneFamily	Fibronectin type III domain containing	PTPRT CNTN6 TYRO3 EBI3 IGSF9B CNTFR	6.64e-05	160	78	6	555
GeneFamily	Membrane associated guanylate kinases\|PDZ domain containing\|Scribble complex	LLGL2 LLGL1	1.10e-04	4	78	2	1224
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PDGFRB CNTN6 TYRO3 HMCN1 IGSF9B	6.58e-04	161	78	5	593
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	PDGFRB TYRO3 CSF1R	6.80e-04	40	78	3	321
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	THADA PKP3 PKP2	8.42e-04	43	78	3	409
GeneFamily	WD repeat domain containing	DMXL2 DMXL1 PWP1 LLGL2 LLGL1 WDFY3	9.39e-04	262	78	6	362
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMD7 JAK2 EPB41L1	1.31e-03	50	78	3	1293
GeneFamily	Beta 3-glycosyltransferases	B3GLCT B3GNT6	4.77e-03	24	78	2	426
GeneFamily	Cyclin dependent kinases	CDK11B CDK2	5.58e-03	26	78	2	496
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	MRC1 STAB1	6.01e-03	27	78	2	1253
ToppCell	cellseq2-Immune-Immune_Myeloid-IM-IM\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MRC1 DMXL2 ABCA1 PTGS1 STAB1 CCDC88A CSF1R EBI3 DSE	9.79e-09	199	134	9	372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCell	cellseq2-Immune-Immune_Myeloid-IM\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MRC1 DMXL2 ABCA1 PTGS1 STAB1 CCDC88A CSF1R EBI3 DSE	9.79e-09	199	134	9	dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	MRC1 DMXL2 ABCA1 STAB1 CCDC88A CSF1R EBI3 WDFY3	7.62e-08	180	134	8	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MRC1 MAGEB2 AADACL4 CPED1 JAK2 CCDC88A CSF1R DSE	9.80e-08	186	134	8	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MRC1 MAGEB2 AADACL4 CPED1 JAK2 CCDC88A CSF1R DSE	9.80e-08	186	134	8	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	Monocytes-M2-like_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	MRC1 ABCA1 CPED1 STAB1 CCDC88A CSF1R EBI3 DSE	1.41e-07	195	134	8	10fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R EBI3	1.65e-07	199	134	8	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	Sepsis-URO\|Sepsis / Disease, condition lineage and cell class	ZNF683 STAB1 JAK3 EBI3 SPON2 PCOLCE2 WDFY3 NMT1	1.65e-07	199	134	8	8e6dac82d1d0e759cd567f9c95b70cb4801d7caf
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL1 CPED1 PTGS1 STAB1 HMCN1 PKP2 NOS3	9.21e-07	172	134	7	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL1 CPED1 PTGS1 STAB1 HMCN1 PKP2 NOS3	9.21e-07	172	134	7	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCAF1 DLL1 FAF1 CNTN6 HMCN1 NYNRIN C5	1.12e-06	177	134	7	75cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 DMXL2 ABCA1 STAB1 CCDC88A CSF1R EBI3	1.34e-06	182	134	7	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 CUBN RHEX SLC13A1 PKHD1 SLC5A12 EPB41L1	1.34e-06	182	134	7	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 CUBN RHEX SLC13A1 PKHD1 SLC5A12 EPB41L1	1.61e-06	187	134	7	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	Monocytes-Tissue-resident_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CPED1 PTGS1 STAB1 B3GNT6 CSF1R PKP2 DSE	1.79e-06	190	134	7	07215e8f292cb54c670037aaf28393cddbe5548c
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	MRC1 DMXL2 STAB1 TG CCDC88A CSF1R PCOLCE2	1.85e-06	191	134	7	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB SORBS1 CPED1 STARD9 IGSF9B ANO3 UNC13A	1.85e-06	191	134	7	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM43 PTGS1 STAB1 TRIM43B HMCN1 PKP2 NOS3	1.92e-06	192	134	7	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TRPC3 SORBS1 CPED1 JAK2 IGSF9B ANO3	1.92e-06	192	134	7	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TRPC3 SORBS1 CPED1 JAK2 IGSF9B ANO3	1.92e-06	192	134	7	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	MRC1 DMXL2 ABCA1 MYO9B CPED1 STAB1 CSF1R	2.06e-06	194	134	7	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.13e-06	195	134	7	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.13e-06	195	134	7	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 ABCA1 STAB1 CCDC88A CSF1R EBI3 DSE	2.13e-06	195	134	7	f289a44010788853d7726d4b5aa75f3c62186c08
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 ABCA1 MYO9B CPED1 STAB1 CCDC88A CSF1R	2.13e-06	195	134	7	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|lung / Disease (COVID-19 only), tissue and cell type	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.20e-06	196	134	7	a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.20e-06	196	134	7	1b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.20e-06	196	134	7	7026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 DMXL2 MYO9B CPED1 CCDC88A CSF1R DSE	2.20e-06	196	134	7	5fe6534af65d43eeacd4b031310242b4f706008b
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 DMXL2 ABCA1 MYO9B STAB1 CSF1R EBI3	2.28e-06	197	134	7	10190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 DMXL2 ABCA1 STAB1 CCDC88A CSF1R EBI3	2.28e-06	197	134	7	e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCell	COVID-19-Myeloid\|COVID-19 / group, cell type (main and fine annotations)	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.35e-06	198	134	7	33f0a919188a67d2a876b52c61a1cec2c9747969
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.35e-06	198	134	7	6b18e18ed88b6043d6a18bd0f4264ec785781e57
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MRC1 DMXL2 ABCA1 MYO9B BIRC7 CCDC88A CSF1R	2.35e-06	198	134	7	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	MRC1 DMXL2 CPED1 STAB1 CSF1R EBI3 WDFY3	2.35e-06	198	134	7	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	MRC1 DMXL2 CPED1 STAB1 CSF1R EBI3 WDFY3	2.35e-06	198	134	7	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MRC1 DMXL2 ABCA1 STAB1 CCDC88A CSF1R WDFY3	2.43e-06	199	134	7	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	MRC1 DMXL2 CPED1 STAB1 CSF1R EBI3 WDFY3	2.43e-06	199	134	7	96070b5ffcbab4952970f43b536969ddd2ca5d14
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 DMXL2 ABCA1 MYO9B STAB1 CSF1R EBI3	2.43e-06	199	134	7	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MRC1 DMXL2 ABCA1 STAB1 CCDC88A CSF1R WDFY3	2.43e-06	199	134	7	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	cellseq-Immune-Immune_Myeloid-IM\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MRC1 DMXL2 ABCA1 STAB1 CSF1R EBI3 DSE	2.43e-06	199	134	7	b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
ToppCell	cellseq-Immune-Immune_Myeloid-IM-IM\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MRC1 DMXL2 ABCA1 STAB1 CSF1R EBI3 DSE	2.43e-06	199	134	7	01dacee8bb392639d475be3cb27ba3eeff1e57f1
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MRC1 DMXL2 ABCA1 MYO9B STAB1 CCDC88A CSF1R	2.52e-06	200	134	7	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	COVID-19-Myeloid-MoAM2,_CCL18\|COVID-19 / Condition, Lineage and Cell class	MRC1 DMXL2 ABCA1 TCIRG1 STAB1 CCDC88A CSF1R	2.52e-06	200	134	7	b0a50622d00335843efad86bc56a1e910019984b
ToppCell	BAL-Severe-Myeloid-MoAM\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 ABCA1 TCIRG1 STAB1 CCDC88A CSF1R DSE	2.52e-06	200	134	7	60bf9f9d4899245463707016e51cd7243f6405b4
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	MRC1 ABCA1 EBI3 NYNRIN WDFY3 EPB41L1	7.86e-06	156	134	6	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 MAGEB2 CPED1 JAK2 CCDC88A CSF1R	8.15e-06	157	134	6	e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 MAGEB2 CPED1 JAK2 CCDC88A CSF1R	8.45e-06	158	134	6	e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCell	NS-critical-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PDGFRB PTGS1 GFI1 STAB1 RHEX NLGN4X	9.08e-06	160	134	6	c61869d9dbba250270e59366e15af204e5b4395d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TRPC3 STARD9 PYGM ANO3 UNC13A	1.08e-05	165	134	6	9de841c1c95967c562720feba930246debc626fd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TRPC3 STARD9 PYGM ANO3 UNC13A	1.08e-05	165	134	6	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB TRPC3 STARD9 PYGM ANO3 UNC13A	1.08e-05	165	134	6	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ABCA1 IDUA CSF1R DSE EPB41L1	1.12e-05	166	134	6	91eeb48680dd07ae4115afacdc0a8f6fa18885e5
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ABCA1 PTGS1 STAB1 CSF1R PKHD1	1.12e-05	166	134	6	bb8135119dc37fdbba476599a56d368f422688dc
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ABCA1 STAB1 CSF1R EBI3 DSE	1.28e-05	170	134	6	6ec0cf055ae55e9fac147f7989c47f83ab07270c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMXL2 ABCA1 MYO9B STAB1 CSF1R NOCT	1.33e-05	171	134	6	5e93c76ee60f9d0590ebb140812653a5e1369417
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ABCA1 STAB1 CSF1R EBI3 DSE	1.37e-05	172	134	6	c96bd3407911df3e3e6d7a3dba786b11814b9598
ToppCell	droplet-Marrow-nan-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 GNL3L ERF CCDC88A CSF1R DSE	1.42e-05	173	134	6	6d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 AADACL4 TRIM43 CPED1 CCDC88A CSF1R	1.42e-05	173	134	6	a55f310c533432e9e26e400026a5b47245152976
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 AADACL4 TRIM43 CPED1 CCDC88A CSF1R	1.42e-05	173	134	6	9c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ABCA1 PTGS1 STAB1 CSF1R DSE	1.56e-05	176	134	6	adb679e69c0c17f0caee4c141bac55d03c963012
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CUBN RHEX LLGL2 SLC13A1 PKHD1 EPB41L1	1.56e-05	176	134	6	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 ABCA1 PTGS1 STAB1 CSF1R DSE	1.61e-05	177	134	6	ab92ffc9624850a50c88e6b8f3a517ff2251ff15
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 CES1 STAB1 CSF1R EBI3 CACNA1G	1.66e-05	178	134	6	24e8c62060455159235985f456af0c5023a7f3f5
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPC3 SORBS1 CPED1 PTGS1 TYRP1 IGSF9B	1.66e-05	178	134	6	8ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 CES1 STAB1 CSF1R EBI3 CACNA1G	1.66e-05	178	134	6	4f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPC3 SORBS1 CPED1 PTGS1 TYRP1 IGSF9B	1.66e-05	178	134	6	6c91331196696e0cf239d105f458e3230659fa38
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 CUBN RHEX SLC13A1 PKHD1 SLC5A12	1.77e-05	180	134	6	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 CUBN RHEX SLC13A1 PKHD1 SLC5A12	1.77e-05	180	134	6	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA1 STAB1 RHEX CCDC88A CSF1R EBI3	1.83e-05	181	134	6	79102845baee5af583eec24e9f91dfec46ab7de3
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 CUBN RHEX SLC13A1 PKHD1 SLC5A12	1.83e-05	181	134	6	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	B3GLCT CNTN6 TG TYRO3 CACNA1G ANO3	1.89e-05	182	134	6	35b2a5625323bf0917214d3b82fafc4a8f5e75ff
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AADACL4 DNAH2 CNTN6 LLGL2 PKHD1	1.90e-05	108	134	5	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMXL2 ABCA1 STAB1 CCDC88A CSF1R DSE	2.01e-05	184	134	6	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 CUBN RHEX SLC13A1 PKHD1 SLC5A12	2.07e-05	185	134	6	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AADACL4 DNAH2 CNTN6 BRCA2 PKHD1	2.07e-05	110	134	5	c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC2\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 STAB1 CCDC88A CSF1R EBI3 DSE	2.13e-05	186	134	6	69b107ad88b07e9aeef09d4e4dac99b0cb6b467e
ToppCell	COVID_non-vent-Myeloid-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	MRC1 CPED1 JAK2 CCDC88A CSF1R DSE	2.20e-05	187	134	6	936aaca144b79a809617cbe3058bf434a4b3d46a
ToppCell	COVID_non-vent-Myeloid-Dendritic-cDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	MRC1 CPED1 JAK2 CCDC88A CSF1R DSE	2.20e-05	187	134	6	55fe4e8b4f301876716c1af15c34d42164f2358e
ToppCell	LPS_only-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MRC1 RNPEPL1 STAB1 CSF1R UNC13A	2.26e-05	112	134	5	9801227fe5a6f5ae1b6c5a9e7fa7f35c4c52efe1
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MRC1 DMXL2 ABCA1 MYO9B STAB1 CSF1R	2.26e-05	188	134	6	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 CPED1 HMCN1 NYNRIN XRN1 CNOT2	2.26e-05	188	134	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 CPED1 HMCN1 NYNRIN XRN1 CNOT2	2.26e-05	188	134	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 CPED1 HMCN1 NYNRIN XRN1 CNOT2	2.26e-05	188	134	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMC1 DLL1 CPED1 NLGN4X CACNA1G DSE	2.26e-05	188	134	6	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 PTGS1 CCDC88A CSF1R EBI3 NYNRIN	2.26e-05	188	134	6	9fc3819aae5a2b2534cb131d467435b5cfc420d6
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 PTGS1 CCDC88A CSF1R EBI3 NYNRIN	2.26e-05	188	134	6	5e5d779ea079d3b2a1ef650b06b9f5cc1ffef5e7
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPED1 PTGS1 STAB1 HMCN1 PKP2 NOS3	2.33e-05	189	134	6	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MRC1 DMXL2 PTGS1 STAB1 RHEX CSF1R	2.33e-05	189	134	6	2aebea7a6c2f83112d7c504b742f2c04b92e459a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB SORBS1 CPED1 JAK2 IGSF9B ANO3	2.33e-05	189	134	6	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	MRC1 CES1 TCIRG1 CSF1R PCOLCE2 DSE	2.33e-05	189	134	6	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB SORBS1 CPED1 JAK2 IGSF9B ANO3	2.33e-05	189	134	6	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	MRC1 DMXL2 MYO9B TCIRG1 ACSS2 LLGL2	2.33e-05	189	134	6	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	CUBN RHEX SLC13A1 SPON2 PKHD1 SLC5A12	2.33e-05	189	134	6	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPED1 PTGS1 STAB1 HMCN1 PKP2 NOS3	2.33e-05	189	134	6	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 MYO9B CPED1 STAB1 CSF1R EBI3	2.40e-05	190	134	6	788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 MYO9B CPED1 STAB1 CSF1R EBI3	2.47e-05	191	134	6	baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCell	control-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TCAF1 PTGS1 GFI1 PWP1 RHEX EPB41L1	2.47e-05	191	134	6	afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC2\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MRC1 STAB1 CCDC88A CSF1R EBI3 DSE	2.55e-05	192	134	6	90274b85f3d612b6a6d435860cd6d049ddeb1d96
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MRC1 CCDC88A CSF1R EBI3 PKP2 DSE	2.55e-05	192	134	6	e24a8856ef01ccf69a5e968bd409f9b84befa91e
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	MAGEB2 PQBP1 GFI1 STAB1 TYRP1 ARNT LLGL1 PKP2 NMT1	1.98e-06	198	129	9	5220_UP
Drug	AC1L3VO5	CA12 PDGFRB JAK2 JAK3 ARNT CSF1R NOS3	4.45e-06	116	129	7	CID000123015
Drug	trichostatin A; Down 200; 0.1uM; HL60; HG-U133A	CA12 ERF PTPRT THADA RBM25 LLGL1 PCOLCE2 NMT1	1.64e-05	196	129	8	364_DN
Drug	Yohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	DMXL2 MIA3 MYO9B RNPEPL1 PQBP1 ARNT SPON2 EPB41L1	1.64e-05	196	129	8	2755_DN
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; HL60; HG-U133A	DMXL2 MYO9B PTDSS2 CLEC4M RBM25 LLGL1 PKP3 IGSF1	1.64e-05	196	129	8	2031_UP
Drug	Solasodine [126-17-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A	BIRC7 C11orf16 PQBP1 PTGS1 GFI1 JAK3 LLGL1 EPS8L3	1.70e-05	197	129	8	3924_UP
Drug	1-phenyl-1,2-propanedione	CES1 OGDH LPO	2.07e-05	10	129	3	CID000011363
Drug	Anilino	PDGFRB PTGS1 JAK3 CDK2	2.09e-05	29	129	4	CID000137550
Drug	AC1NS6G5	PDGFRB JAK2	3.19e-05	2	129	2	CID005329277
Drug	Probucol	ABCA1 CES1	3.19e-05	2	129	2	DB01599
Drug	3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile	JAK2 JAK3	3.19e-05	2	129	2	DB08183
Drug	2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE	JAK2 JAK3	3.19e-05	2	129	2	DB04716
Disease	mean reticulocyte volume	MYO9B RNPEPL1 TRPC3 DNAH2 ZNF217 KBTBD2 IDUA CPED1 FAF1 JAK2 THADA MAGED2 NYNRIN PCOLCE2	1.46e-05	799	132	14	EFO_0010701
Disease	Malignant neoplasm of breast	MAP2K4 ELP1 SORBS1 CUBN NUDT17 DLL1 PTGS1 CNTN6 CRYAA LLGL2 LLGL1 CSF1R BRCA2 MAGED2 L3MBTL3 NOS3	2.56e-05	1074	132	16	C0006142
Disease	Breast Carcinoma	MAP2K4 ELP1 NUDT17 DLL1 PTGS1 LLGL2 LLGL1 CSF1R BRCA2 L3MBTL3 NOS3	3.18e-05	538	132	11	C0678222
Disease	autism spectrum disorder (implicated_via_orthology)	PDGFRB NLGN4Y LAMC1 NLGN4X PKP2 WDFY3	6.50e-05	152	132	6	DOID:0060041 (implicated_via_orthology)
Disease	non-high density lipoprotein cholesterol measurement	TDRD15 ABCA1 LAMC1 GFI1 THADA CSF1R BRCA2 NYNRIN XRN1 PCOLCE2 MTX1 L3MBTL3	8.99e-05	713	132	12	EFO_0005689
Disease	Neutropenia, Severe Congenital, Autosomal Dominant 1	TCIRG1 GFI1	1.18e-04	4	132	2	C1859966
Disease	myeloproliferative neoplasm (implicated_via_orthology)	PDGFRB JAK2	1.18e-04	4	132	2	DOID:2226 (implicated_via_orthology)
Disease	Mammary Carcinoma, Human	ELP1 NUDT17 DLL1 PTGS1 LLGL2 LLGL1 CSF1R BRCA2 L3MBTL3 NOS3	1.31e-04	525	132	10	C4704874
Disease	Mammary Neoplasms, Human	ELP1 NUDT17 DLL1 PTGS1 LLGL2 LLGL1 CSF1R BRCA2 L3MBTL3 NOS3	1.31e-04	525	132	10	C1257931
Disease	Mammary Neoplasms	ELP1 NUDT17 DLL1 PTGS1 LLGL2 LLGL1 CSF1R BRCA2 L3MBTL3 NOS3	1.35e-04	527	132	10	C1458155
Disease	liver cancer (biomarker_via_orthology)	CES1 JAK2	1.97e-04	5	132	2	DOID:3571 (biomarker_via_orthology)
Disease	Adult Diffuse Large B-Cell Lymphoma	JAK2 CDK2	1.97e-04	5	132	2	C1332201
Disease	neuroblastoma (implicated_via_orthology)	LLGL2 LLGL1	1.97e-04	5	132	2	DOID:769 (implicated_via_orthology)
Disease	transient cerebral ischemia (implicated_via_orthology)	MAP2K4 OPA1 JAK2 NOS3	1.97e-04	64	132	4	DOID:224 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	LLGL2 LLGL1 L3MBTL3	2.11e-04	26	132	3	DOID:1319 (implicated_via_orthology)
Disease	renal cell carcinoma (is_implicated_in)	PDGFRB ARNT CSF1R CDK2	2.64e-04	69	132	4	DOID:4450 (is_implicated_in)
Disease	platelet-derived growth factor receptor beta measurement	PDGFRB CSF1R	2.94e-04	6	132	2	EFO_0008265
Disease	MEDULLOBLASTOMA	ELP1 BRCA2	2.94e-04	6	132	2	155255
Disease	Medulloblastoma	ELP1 BRCA2	2.94e-04	6	132	2	cv:C0025149
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK2 JAK3	4.11e-04	7	132	2	DOID:14566 (implicated_via_orthology)
Disease	infertility (implicated_via_orthology)	CSF1R BRCA2	4.11e-04	7	132	2	DOID:5223 (implicated_via_orthology)
Disease	Spinocerebellar Ataxia Type 2	TRPC3 GFI1 CACNA1G	4.73e-04	34	132	3	C0752121
Disease	Spinocerebellar Ataxia Type 1	TRPC3 GFI1 CACNA1G	4.73e-04	34	132	3	C0752120
Disease	Spinocerebellar Ataxia Type 5	TRPC3 GFI1 CACNA1G	4.73e-04	34	132	3	C0752123
Disease	Spinocerebellar Ataxia Type 7	TRPC3 GFI1 CACNA1G	4.73e-04	34	132	3	C0752125
Disease	Spinocerebellar Ataxia Type 6 (disorder)	TRPC3 GFI1 CACNA1G	4.73e-04	34	132	3	C0752124
Disease	Ataxia, Spinocerebellar	TRPC3 GFI1 CACNA1G	4.73e-04	34	132	3	C0087012
Disease	Spinocerebellar Ataxia Type 4	TRPC3 GFI1 CACNA1G	5.16e-04	35	132	3	C0752122
Disease	free cholesterol in small HDL measurement	TDRD15 ABCA1 NYNRIN	5.16e-04	35	132	3	EFO_0022270
Disease	cathepsin S measurement	MIA3 ARNT	5.46e-04	8	132	2	EFO_0008073
Disease	colorectal carcinoma (is_marker_for)	CA12 CSF1R BRCA2	6.08e-04	37	132	3	DOID:0080199 (is_marker_for)
Disease	Glioma	ELP1 BRCA2	7.00e-04	9	132	2	cv:C0017638
Disease	urate measurement	CA12 ABCA1 NAALADL1 CUBN PTPRT FAF1 STAB1 SPATA17 C11orf68 PKHD1 PYGM MTX1	7.06e-04	895	132	12	EFO_0004531
Disease	lipid measurement, lipoprotein measurement	TDRD15 ABCA1 LLGL1 NYNRIN	7.26e-04	90	132	4	EFO_0004529, EFO_0004732
Disease	Agents acting on the renin-angiotensin system use measurement	MIA3 B3GLCT MYO9B CRYAA PKHD1 ANO3 NOS3	8.02e-04	335	132	7	EFO_0009931
Disease	medulloblastoma (is_implicated_in)	ELP1 BRCA2	8.73e-04	10	132	2	DOID:0050902 (is_implicated_in)
Disease	hydroxyproline measurement	CA12 PTPRT	8.73e-04	10	132	2	EFO_0010498
Disease	melanoma	CUBN TYRP1 ARNT BRCA2 C11orf68 CDK2	8.99e-04	248	132	6	C0025202
Disease	Cognitive impairment	PTPRT DMXL1	1.06e-03	11	132	2	HP_0100543
Disease	kidney cancer (implicated_via_orthology)	LLGL2 LLGL1	1.06e-03	11	132	2	DOID:263 (implicated_via_orthology)
Disease	cardiovascular disease	TDRD15 B3GLCT MYO9B SORBS1 THADA PKHD1 NMT1 NOS3	1.08e-03	457	132	8	EFO_0000319
Disease	Colorectal Carcinoma	ABCA1 RNPEPL1 LAMC1 ZNF217 CUBN PQBP1 PTPRT ARNT NLGN4X PKHD1	1.26e-03	702	132	10	C0009402
Disease	Hematologic Neoplasms	JAK2 CSF1R	1.27e-03	12	132	2	C0376545
Disease	lymphangioleiomyomatosis (is_marker_for)	ACSS2 NOS3	1.27e-03	12	132	2	DOID:3319 (is_marker_for)
Disease	lipoprotein measurement	TDRD15 ABCA1 CES1 LLGL1	1.29e-03	105	132	4	EFO_0004732
Disease	cancer (implicated_via_orthology)	DLL1 LLGL2 LLGL1 CSF1R BRCA2 CDK2	1.34e-03	268	132	6	DOID:162 (implicated_via_orthology)
Disease	hematologic cancer (implicated_via_orthology)	JAK2 JAK3	1.50e-03	13	132	2	DOID:2531 (implicated_via_orthology)
Disease	Benign tumor of pancreas	MAP2K4 BRCA2	1.50e-03	13	132	2	C0347284
Disease	extracellular matrix protein 1 measurement	MIA3 ARNT	1.50e-03	13	132	2	EFO_0008126
Disease	Congenital Hypothyroidism	TG IGSF1	1.50e-03	13	132	2	C0010308
Disease	HMG CoA reductase inhibitor use measurement	TDRD15 ABCA1 MIA3 BRCA2 NOS3	1.64e-03	189	132	5	EFO_0009932
Disease	total lipids in LDL measurement	TDRD15 ABCA1 NYNRIN	1.65e-03	52	132	3	EFO_0022308
Disease	free cholesterol measurement	TDRD15 ABCA1 LLGL1 NYNRIN	1.69e-03	113	132	4	EFO_0008591
Disease	low density lipoprotein cholesterol measurement, lipid measurement	TDRD15 ABCA1 BRCA2 NYNRIN	1.75e-03	114	132	4	EFO_0004529, EFO_0004611
Disease	von Willebrand factor measurement, coronary artery disease	TDRD15 MIA3 CLEC4M NOS3	1.98e-03	118	132	4	EFO_0001645, EFO_0004629
Disease	nasopharynx carcinoma (is_implicated_in)	MAP2K4 CSF1R	2.01e-03	15	132	2	DOID:9261 (is_implicated_in)
Disease	metabolic syndrome	ABCA1 NAALADL1 MIA3 TYRO3 ARNT	2.10e-03	200	132	5	EFO_0000195
Disease	low density lipoprotein cholesterol measurement, phospholipid measurement	TDRD15 ABCA1 BRCA2 NYNRIN	2.11e-03	120	132	4	EFO_0004611, EFO_0004639
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 PKHD1	2.29e-03	16	132	2	DOID:0110861 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_marker_for)	CA12 MAP2K4 ABCA1 CES1 JAK2 CSF1R	2.40e-03	301	132	6	DOID:684 (is_marker_for)
Disease	cholesteryl ester measurement, low density lipoprotein cholesterol measurement	TDRD15 ABCA1 BRCA2 NYNRIN	2.51e-03	126	132	4	EFO_0004611, EFO_0010351
Disease	ocular hypertension (biomarker_via_orthology)	OPA1 CRYAA	2.58e-03	17	132	2	DOID:9282 (biomarker_via_orthology)
Disease	pre-eclampsia (biomarker_via_orthology)	EBI3 NOS3	2.58e-03	17	132	2	DOID:10591 (biomarker_via_orthology)
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	JAK2 JAK3 ARNT	2.61e-03	61	132	3	C1961102
Disease	esterified cholesterol measurement	TDRD15 ABCA1 LLGL1 NYNRIN	2.66e-03	128	132	4	EFO_0008589
Disease	cortical surface area measurement	MYO9B LAMC1 IDUA RETSAT CPED1 FAF1 TG THADA CCDC88A PKD1 XRN1 PKHD1 L3MBTL3 RHOT1	2.85e-03	1345	132	14	EFO_0010736
Disease	Gastric ulcer	PTGS1 NOS3	2.90e-03	18	132	2	C0038358
Disease	carcinoma (implicated_via_orthology)	LLGL2 LLGL1 CSF1R	2.99e-03	64	132	3	DOID:305 (implicated_via_orthology)
Disease	apolipoprotein B measurement	TDRD15 THADA SLC2A4RG LLGL1 BRCA2 NYNRIN PCOLCE2 EPS8L3 L3MBTL3	3.04e-03	663	132	9	EFO_0004615
Disease	portal hypertension (implicated_via_orthology)	JAK2 NOS3	3.23e-03	19	132	2	DOID:10762 (implicated_via_orthology)
Disease	Pancreatic carcinoma	MAP2K4 BRCA2	3.23e-03	19	132	2	C0235974
Disease	Hypertriglyceridemia	TDRD15 LAMC1	3.23e-03	19	132	2	EFO_0004211
Disease	familial hyperlipidemia (biomarker_via_orthology)	ABCA1 NOS3	3.23e-03	19	132	2	DOID:1168 (biomarker_via_orthology)
Disease	polycystic kidney disease (biomarker_via_orthology)	PTGS1 NOS3	3.23e-03	19	132	2	DOID:0080322 (biomarker_via_orthology)
Disease	low density lipoprotein cholesterol measurement, physical activity	TDRD15 OGDH NYNRIN	3.26e-03	66	132	3	EFO_0003940, EFO_0004611
Disease	histidine measurement	TRPC3 NYNRIN CNOT2	3.26e-03	66	132	3	EFO_0009769
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 ABCA1 LLGL1 NYNRIN	3.40e-03	137	132	4	EFO_0004611, EFO_0008591
Disease	lung non-small cell carcinoma (is_implicated_in)	CA12 MAP2K4 JAK2 CSF1R	3.58e-03	139	132	4	DOID:3908 (is_implicated_in)
Disease	bipolar I disorder	TDRD15 B3GLCT CUBN STARD9	3.76e-03	141	132	4	EFO_0009963
Disease	gastric ulcer (biomarker_via_orthology)	IDUA NOS3	3.94e-03	21	132	2	DOID:10808 (biomarker_via_orthology)
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	TDRD15 ABCA1 CES1 OGDH	4.06e-03	144	132	4	EFO_0004611, EFO_0020943
Disease	hip circumference	INTS6L PTPRT FAF1 HMCN1 L3MBTL3 EPB41L1	4.23e-03	338	132	6	EFO_0005093
Disease	otitis media (implicated_via_orthology)	IDUA PHEX	4.33e-03	22	132	2	DOID:10754 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPAFKDRVPEYPAWF	UNC13A	1131	Q9UPW8
YIKAWPPAGVSLPDD	ARNT	311	P27540
TPGFAFPDWAYKPES	ERFL	21	A0A1W2PQ73
FPDWAYKPESSPGSR	ERFL	26	A0A1W2PQ73
FPDWAYKPESSPGSR	ERF	11	P50548
AEPWSFVKNATSYPP	CES1	71	P23141
GKAYLPWSYFPPNVT	C4orf33	116	Q8N1A6
PWSYFPPNVTKFNSF	C4orf33	121	Q8N1A6
VSPYPFKWMDTGIAP	ERVK13-1	131	Q9NX77
FKYPDFAAGWALSIP	B3GLCT	181	Q6Y288
YPQFWISPSLRPTFE	CPED1	821	A4D0V7
WNGKERSIYFQPPSF	AIFM1	196	O95831
GIPRPWYFPCTKSYW	ABCA1	851	O95477
LASFYDWPLTAEVPP	BIRC7	91	Q96CA5
PWSPGPFNEAAYLEA	AADACL4	301	Q5VUY2
TPSEKIWPGYSELPA	CDK11B	656	P21127
PPELSMWDYFVAKPF	DMXL2	2451	Q8TDJ6
AKEFYWKTPCPGPFL	ACSS2	66	Q9NR19
WKTPCPGPFLRYNFD	ACSS2	71	Q9NR19
KFPYRLSWLTEPDPE	C3orf22	26	Q8N5N4
PPELSIWDYFIAKPF	DMXL1	2426	Q9Y485
RGPPWSSKPYEFTLQ	ANO3	891	Q9BYT9
ATGRFPYPKWNSVFD	MAP2K4	301	P45985
PTAKPELFAYPLDWS	RBM25	746	P49756
SASWFPSYPNLIKPT	INTS6L	651	Q5JSJ4
KEPGESPIFWYAPES	JAK2	1011	O60674
PGQSPIFWYAPESLS	JAK3	986	P52333
DWPPFRKVGCFDPYS	LLGL1	496	Q15334
LITPPGYPNVKHFSW	L3MBTL3	436	Q96JM7
PAEPWNFVKNATSYP	CES1P1	71	Q9UKY3
PWNFAFTVKFYPPDP	EPB41L1	166	Q9H4G0
SDPPRFQFLWGPRAY	MAGEB2	266	O15479
VPNSNPPEYEFFWGL	MAGED2	431	Q9UNF1
VPRSSPVEYEFFWGP	MAGEH1	151	Q9H213
EWPPLRKVGSFDPYS	LLGL2	486	Q6P1M3
DYSPEFLLWALRPPG	NMT1	191	P30419
EAQPFPLPFKPYSWS	GFI1	111	Q99684
PLPFKPYSWSGLAGS	GFI1	116	Q99684
LVGRPFFPPYWSLGF	MGAM2	321	Q2M2H8
SAYPPRLSWGLPKYH	NUDT17	166	P0C025
TWKPVPDSHQGPAFY	GLB1L3	561	Q8NCI6
FFYVDKPPQVPRWSP	FRMD7	496	Q6ZUT3
PSSPAPVNGSKWTYF	CA12	21	O43570
YKFYDPSPPRRRGNW	CCDC88A	1381	Q3V6T2
QSDFCPWYTGLPFIP	GSPT2	401	Q8IYD1
DLFKVFPYIPWGPDV	RHOT1	331	Q8IXI2
ITKVPRDPFWANSYP	LPO	676	P22079
WTGDEPLPYQPTFSD	EPS8L3	376	Q8TE67
LEESPWKPPTYLFST	KBTBD2	591	Q8IY47
PAPPKIYFPIRDSWN	MICOS13	71	Q5XKP0
FLWYDGSLKSVPPPD	DSE	371	Q9UL01
FRASIWGPAGYPSPV	LCA10	41	Q71F78
KPWKNSGGFPVRFPY	ELP1	591	O95163
PSGSFKTPNWPDRDY	PCOLCE2	161	Q9UKZ9
KTPNWPDRDYPAGVT	PCOLCE2	166	Q9UKZ9
NPICSPEYWKPSTFG	PTGS1	536	P23219
QVSNSDPPRYKFPWG	MAGEA13P	256	A6NCF6
SYPPATITWFKDGTP	HMCN1	2601	Q96RW7
PAFRYQPDPWKGSAA	NOS3	471	P29474
QYIGWPAYRDTPPSK	PTPRT	1336	O14522
EGLPPSWYKVFDPSC	PQBP1	46	O60828
SPIKYGYQPRRNFWP	OPA1	76	O60313
FPYGTRRSPAKIWPT	NLGN4Y	621	Q8NFZ3
KPVWYAGRDPAAAPA	OGDH	981	Q02218
PKWEQFLLGRAPYPF	C3orf14	96	Q9HBI5
DAPVFLFSPGWPDSY	CUBN	1986	O60494
WTYLGPFSDHQPEPK	CSF1R	336	P07333
YPKPFFKTWASPVVT	IGSF1	776	Q8N6C5
GWPSAFQKPKGRLPY	ICE2	696	Q659A1
ARWYTKLGFFPDPRP	BRCA2	2786	P51587
VSGPSPPLARAYSFW	CACNA1G	2156	O43497
NPIRFPFGFTWPGTF	DLL1	106	O00548
YDDQAWARPPKPPTF	CCDC9	316	Q9Y3X0
PGFYTPAELKPFWER	GALNT6	91	Q8NCL4
PDFKIPSNPRYGMWT	C5	186	P01031
TWPDPESFPLKFFLR	CNTFR	231	P26992
PPGSWPFPEIFSLKY	EBI3	151	Q14213
PPPHFGDLSYAWTFN	CNTN6	146	Q9UQ52
RALDYWARPGPFSDP	IDUA	621	P35475
TDYPWRPALTPFEFQ	LAMC1	631	P11047
KGFPWDEYKLLSTFP	FAF1	606	Q9UNN5
QHPWFKRTLGPFYPS	CRYAA	6	P02489
VWPGVTSMPDYKPSF	CDK2	226	P24941
WSKYFVPPQLFPGSA	B3GNT6	261	Q6ZMB0
ARPPVIFWLSGFTFP	DNAH2	4271	Q9P225
PGFVPGWSALFSEYP	SLC13A1	366	Q9BZW2
FPYGTRRSPAKIWPT	NLGN4X	621	Q8N0W4
GYQGTFFPKPWSPCL	NOCT	211	Q9UK39
EAYPPPTVLWFKDNR	PDGFRB	341	P09619
ALWREFLFSVPAGPP	PKD1	681	P98161
PNTRWVEAFPLKPYT	NYNRIN	1641	Q9P2P1
ILSLYFPWDGAEVPP	MTX1	386	Q13505
SPFRYLNWLPGSPSA	MRC1	296	P22897
PLLFFAFPSAKDPTW	RETSAT	436	Q6NUM9
WPSVYPVAAPFKPSA	MRPS35	66	P82673
GIYNSPFRKEPDPWE	SPATA17	176	Q96L03
WGRYDIVFLPPSFPI	RNPEPL1	311	Q9HAU8
WSYPAGSLTFPVRPF	TRIM43	426	Q96BQ3
KIPWTPPGTALQFYS	TMEM179B	146	Q7Z7N9
TGFPWAFKVPGLPQY	THADA	1501	Q6YHU6
PSFWYFVNPALSEPA	RHEX	151	Q6ZWK4
WSQTAFPKQYPLFRP	SPON2	51	Q9BUD6
FPKQYPLFRPPAQWS	SPON2	56	Q9BUD6
PESSWPYKEYIFRPG	TDRD15	741	B5MCY1
WAFKNPGVSPLARFP	TCAF1	366	Q9Y4C2
GPDFYGLPWKPVFIT	MIA3	1171	Q5JRA6
DWVSGKISFYIPPPA	GNL3L	391	Q9NVN8
QAKDGPFSRPHPAYW	PTDSS2	111	Q9BVG9
SRFIPWFPYDGSKLP	SHLD3	36	Q6ZNX1
YPKFQPPWDNVTGTT	PKHD1	2376	P08F94
FGSSDISPYALPWRP	STARD9	3461	Q9P2P6
QTAWFPAPYLEEAAP	NOXO1	211	Q8NFA2
PRFTNEPYPLFVTWK	AMMECR1	151	Q9Y4X0
LEWFPLNKPSVGDYF	CLN6	71	Q9NWW5
PLSPSFQRYWNSGEP	CLEC4M	346	Q9H2X3
PPWDLSFTYPFALQA	C11orf16	31	Q9NQ32
TPATELDAWLAKYPP	C11orf68	86	Q9H3H3
SPENLYPKFASPWAS	CNOT2	391	Q9NZN8
FRPIAKPAYSPASWS	PKP3	106	Q9Y446
AYPLSVEWLNFDPSP	PWP1	186	Q13610
AQEWKPPLPAYDFLS	TXNDC16	736	Q9P2K2
EPSFSLPYWNFATGK	TYRP1	241	P17643
ERFFPPPSGLSYSSW	WDFY3	1091	Q8IZQ1
YGNPWEKARPEFTLP	PYGM	186	P11217
PWKEALVRPPGSYSS	SLC2A4RG	136	Q9NR83
VTGQPPPYVVEWFKF	IGSF9B	51	Q9UPX0
PSTFGLDTRWYEPQP	IGSF9B	1161	Q9UPX0
RSFYPAPGPWPKSFS	SOGA3	796	Q5TF21
PWYKFFSELEFGKPP	SORBS1	566	Q9BX66
DTEFIYPSPWPEKFP	XRN1	606	Q8IZH2
QKPFFWGTEYPRSLS	PHEX	556	P78562
FANFTFPRLPGKWPF	SNX27	211	Q96L92
FYPKFWTSPPLHSLG	STAB1	1911	Q9NY15
AKNDSPWAPPGRDYF	ZNF217	886	O75362
WSYPAGSLTFPVRPF	TRIM43B	426	A6NCK2
AFIYPAPASKTWPLP	SLC5A12	456	Q1EHB4
PYEFSRKVPTFATPW	TG	2671	P01266
IIIPFSGWPEGDYPK	PKP2	531	Q99959
ANALGPSPYADWVPF	TYRO3	301	Q06418
PSPYADWVPFQTKGL	TYRO3	306	Q06418
PYPFGIDPIWSLAAN	TCIRG1	511	Q13488
PSARWETLLPYPGAF	ZNF683	246	Q8IZ20
WLSYFDDGKTLPPPF	TRPC3	681	Q13507
ETFPNSWYLPPSGVE	NAALADL1	231	Q9UQQ1
APWPLKLGFSSPYEG	MYO9B	1916	Q13459