Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenohyperdipsia

AGRP CHRM5

1.63e-052572MP:0005111
Pubmed

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.

SKI RNF111

5.90e-06285219959502
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TIMM17B ZBTB2 SF3B3 PNPLA6 CHAF1A RSF1 MAIP1 SKI TOPORS PLEKHN1 ENKD1 PARS2

1.71e-051116851231753913
Pubmed

Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.

ARVCF TXNRD2

1.77e-05385219617637
Pubmed

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.

SKI RNF111

3.53e-05485217510063
Pubmed

Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts.

SKI RNF111

3.53e-05485218950738
Pubmed

Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.

SKI RNF111

5.87e-05585218451154
Pubmed

RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

SKI RNF111

5.87e-05585221795712
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VWA5B2 CPTP FLNA CELSR1 PNPLA6 MEGF8 ARVCF SPIRE1 GRIN2D TXNRD2 HERC2

7.89e-051105851135748872
Pubmed

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.

CHAF1A TOPORS RNF111

1.12e-043885328680062
Pubmed

Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation.

FLNA SF3B3 MVP

1.51e-044285334581821
Pubmed

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.

TIMM17B ARVCF PRAF2 PARS2

2.27e-0412185431900314
Pubmed

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.

FLNA MVP

3.20e-041185236411454
Pubmed

UBR7 acts as a histone chaperone for post-nucleosomal histone H3.

CHAF1A RSF1

3.20e-041185234786730
Pubmed

The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-β signaling.

SKI RNF111

3.83e-041285223537899
Pubmed

Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation.

SKI RNF111

4.52e-041385223530056
Pubmed

Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.

MARS2 PARS2

5.27e-041485215779907
Pubmed

A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.

CELSR1 NEUROG2

5.27e-041485225191221
Pubmed

Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm.

SPRY4 NEUROG2

5.27e-041485216172976
Pubmed

Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.

GDF7 NEUROG2

8.80e-041885231869353
Pubmed

Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube.

GDF7 NEUROG2

8.80e-041885233892704
Pubmed

A refined map of early gene expression in the dorsal rhombomere 1 of mouse embryos.

GDF7 NEUROG2

1.20e-032185220206242
Pubmed

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FLNA WDR81 ALS2CL

1.20e-038585315449545
Pubmed

Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.

GDF7 NEUROG2

1.32e-032285217150208
Pubmed

Central roles of the roof plate in telencephalic development and holoprosencephaly.

GDF7 NEUROG2

1.32e-032285216855091
Pubmed

Positional cloning of the mouse saccharin preference (Sac) locus.

CPTP SKI

1.32e-032285211555487
Pubmed

Genome-wide association study identifies five new breast cancer susceptibility loci.

MYEOV ZNF365

1.32e-032285220453838
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

MARS2 CELSR1 PNPLA6 ACSF3 TXNRD2 PRAF2 PARS2

1.47e-0368685728380382
Pubmed

Cascade diversification directs generation of neuronal diversity in the hypothalamus.

AGRP NEUROG2

1.57e-032485233887179
Pubmed

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.

DAND5 ENKD1

1.57e-032485229257953
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

TIMM17B MARS2 FAM210A SUPV3L1 ACSF3 PYURF MAIP1 TXNRD2 PARS2

1.83e-03113685934800366
Pubmed

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

MST1 ZNF365

2.14e-032885218587394
Pubmed

Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.

NEUROG2 IGFBPL1

2.30e-032985230048641
CytobandEnsembl 112 genes in cytogenetic band chr16q22

SF3B3 CARMIL2 AGRP ENKD1

3.85e-04183854chr16q22
Cytoband1p36.33

CPTP SKI PLEKHN1

4.06e-04778531p36.33
Cytoband16q22.1

SF3B3 CARMIL2 ENKD1

1.15e-0311085316q22.1
Cytoband22q11.21

ARVCF RTN4R TXNRD2

1.18e-0311185322q11.21
GeneFamilyRing finger proteins

LNX2 ZNRF4 TOPORS RNF217 RNF111

6.46e-0427546558
CoexpressionGSE20366_CD103_POS_VS_NEG_TREG_KLRG1NEG_UP

MARS2 DAND5 CELSR1 SPRY4 ACSF3 ZNRF4 ALS2CL

3.74e-06200847M4335
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CELSR1 FRMD6-AS1 CCM2L NFKBIB PTGER2

9.55e-061488551d9fa6b2ee9feaed39c63d44e638b5c0942d947c
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CELSR1 FRMD6-AS1 CCM2L NFKBIB RNF32-DT

1.02e-0515085598fdc6bdfde84d680e11d8727502b79afbf64303
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CILP2 CELSR1 CCM2L APOLD1 GDF15

1.57e-051648554cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CILP2 CELSR1 CCM2L APOLD1 GDF15

1.57e-051648557a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CILP2 CELSR1 CCM2L APOLD1 GDF15

1.57e-051648555e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CILP2 CELSR1 CCM2L APOLD1 GDF15

1.57e-05164855f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
DiseaseMouth Diseases

GDF15 CHAF1A

4.83e-0412812C0026636
Diseaselevel of Phosphatidylethanolamine (18:1_18:1) in blood serum

RAB3IL1 RNF111

6.63e-0414812OBA_2045142
Diseasephosphatidylethanolamine measurement

NECAB2 WDR81 RAB3IL1 RNF111

1.34e-03173814EFO_0010228
Diseaselevel of Phosphatidylethanolamine (16:0_18:2) in blood serum

RAB3IL1 RNF111

1.98e-0324812OBA_2045136
DiseaseMalignant neoplasm of breast

PIK3R4 MST1 FLNA FAM210A GRIN2D HERC2 ALS2CL ZNF365 PDZD4

2.71e-031074819C0006142

Protein segments in the cluster

PeptideGeneStartEntry
PRSSRRCVRLHESCL

AGRP

81

O00253
TLRGRLRDVLCTPAH

ALS2CL

216

Q60I27
RLARRTCLEPHNAGL

FAM210A

11

Q96ND0
ARAAKRAPRRHSCSL

ENKD1

206

Q9H0I2
TRRRPECGRGLHTRA

ARVCF

286

O00192
SRHLERCPGALRRLS

CARMIL2

296

Q6F5E8
RARLTRPHRSCRDPA

ASB16

46

Q96NS5
GPGSCRRHQAAARRL

ASB16

256

Q96NS5
LASCRLAPARHRGSG

ACSF3

16

Q4G176
LSRRLRARTHLPGCG

CELSR1

101

Q9NYQ6
RARTHLPGCGARARL

CELSR1

106

Q9NYQ6
RIAHTRALSVGNCPR

C1orf147

166

Q96MC9
CRRGLLSNHTGSPRS

CHAF1A

761

Q13111
RRAACRSSVSRRPLH

CCM2L

26

Q9NUG4
ICHRRGIRSLRDLTP

DCPS

221

Q96C86
PRRLSGLCARRRSQA

DANCR

66

P0C864
FAVVRSPRRLCGRSH

RNF32-DT

86

Q8NI28
GLTRTCRHRIRLGDS

RAB3IL1

306

Q8TBN0
PLRRVSRLHGCRSER

KCNG3

31

Q8TAE7
CHRLRARGTRKARAG

APOLD1

6

Q96LR9
CPRRLFSRRSPAKLH

PNPLA6

936

Q8IY17
SRPGCSAIRLRNHLC

DAND5

111

Q8N907
CLARDPARRPSAHSL

NRBP2

286

Q9NSY0
FLHSRSLPCGAVRLR

MAIP1

11

Q8WWC4
GLVHDCKRRPSRARA

NEUROG2

81

Q9H2A3
PASKSRLCSHRRALG

HERC2

1371

O95714
RCPGASHRRVALERR

LNX2

136

Q8N448
RVGAHACARALLQPR

NFKBIB

136

Q15653
RRSPRLRGDSSCHDL

PDZD4

51

Q76G19
HRRSRRSRCGPSLGS

PTGER2

226

P43116
CSCAHSARRRGPPRA

INSIG1

11

O15503
CALRLRARHTPRAHP

IGFBPL1

126

Q8WX77
RRLRTCSECLARHPR

MEGF8

1926

Q7Z7M0
RGRRACLTLHRHPTP

MYEOV

231

Q96EZ4
GPGRCCRLHTVRASL

GDF15

206

Q99988
SAGRPKRPHARRALC

MVP

501

Q14764
RAQSLSHGLRLAAPC

PTK6

156

Q13882
ACTGRSKRHRSRALG

FRG2B

151

Q96QU4
RRRRAPSVANVGSHC

FLNA

2146

P21333
RRSHHPESGCRTVLR

CPTP

96

Q5TA50
PESGCRTVLRLHRAL

CPTP

101

Q5TA50
CGGRSLHLPQLRFSR

TMEM132E-DT

21

A2RUQ5
CHLSPISRSCTRNRR

IGFL3

106

Q6UXB1
RSRQGSARGAKPHRC

GLI4

171

P10075
SCSPLPARHSRRRAS

FRMD6-AS1

331

P0C7T7
PRPSSCARLRHVARG

IFNL4

71

K9M1U5
HSPHTRLRRSGRCDL

MST1

86

P26927
TDFCSRRLRRHPSRP

RSF1

1141

Q96T23
RPGCSRKNRTRSHCR

RTN4R

416

Q9BZR6
RCALVRARPAHPALR

RASL10A

176

Q92737
HCAPRRGRRLLLSRV

PARS2

31

Q7L3T8
HRTPCRRRAGCQRKG

TSGA10IP

261

Q3SY00
DRLRRPGCRCKHTNS

SPRY4

266

Q9C004
RRCHSAPPQRRLTRL

PLEKHN1

196

Q494U1
RHCRRLSEVRGGGLT

SKA1

236

Q96BD8
ARSRAHAPSRGRRAR

PPP1R3E

51

Q9H7J1
TRAPPSAVARRCLHA

PYURF

16

Q96I23
HGRRGRSRCSRKPLH

GDF7

341

Q7Z4P5
ERPHLRRLVRGSVCA

RNF217

481

Q8TC41
RQAGHRAAICSALRP

SUPV3L1

16

Q8IYB8
ERLRLVSGPHRCAGR

SSC5D

196

A1L4H1
SLGCVHPRQRLSAFR

SKI

366

P12755
RHRRRGSPTRCAHCP

SPEM1

111

Q8N4L4
HRALFRSCLRCPRPT

CHRM5

246

P08912
RRLRRRHCPSPAGDA

CILP2

166

Q8IUL8
RLPAHDLSGRLARLC

TMEM95

21

Q3KNT9
ISSHCHPSRARIRRL

PIK3R4

1176

Q99570
PQRRCRHLVSRAGTP

nan

71

P0C880
ARRHPARNGSRLACT

ZNF503-AS2

51

A6NEH8
LRCPRCGDHTRFRSL

ZNF365

26

Q70YC5
CLHGSSLRRLPCRKR

RNF111

201

Q6ZNA4
VRRCRRSHPAACLAA

PRAF2

91

O60831
CGSLRAAARRRQPRH

SPIRE1

66

Q08AE8
GRCFSESSTLLRHRR

ZNF672

261

Q499Z4
RSRRLELLGRASPHC

ZNRF4

391

Q8WWF5
RGSRRTLAVLAAHCP

VWA2

261

Q5GFL6
ALCRHRRLRGPSTAA

MARS2

71

Q96GW9
ACGRGPRSSLRVLRH

SF3B3

426

Q15393
HRLRGSANAVRIRAP

TIMM17B

46

O60830
RLCRASPFAVHRASL

VWA5B2

1086

Q8N398
SRRVRLRGSCRHRPS

TOPORS

31

Q9NS56
LRGSCRHRPSFLGCR

TOPORS

36

Q9NS56
HGTRFLRGCAPSRVR

TXNRD2

271

Q9NNW7
CHLCGRRFTLRSSLR

ZBTB2

256

Q8N680
CLAANPRTGRRRRSL

VSIG10L

471

Q86VR7
RTRHLLRPSLNSRTC

THSD7B

1151

Q9C0I4
GLSRHRRIHSGARRC

ZNF275

391

Q9NSD4
GHCHARALAILRARP

TTC34

136

A8MYJ7
RRTPRSVLCGHVRAQ

WDR81

456

Q562E7
RLTGPSRHARRCPHA

GRIN2D

1286

O15399
ARLCRAGAHRLLREP

NECAB2

6

Q7Z6G3