Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE2A PDE3A PDE6C PDE6B PDE5A	4.86e-08	22	93	5	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE2A PDE3A PDE6C PDE6B PDE5A	7.79e-08	24	93	5	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE2A PDE3A PDE6C PDE6B PDE5A	9.70e-08	25	93	5	GO:0004114
GeneOntologyMolecularFunction	phenanthrene-9,10-epoxide hydrolase activity	AKR7A2 AKR7L AKR7A3	9.78e-08	3	93	3	GO:0019119
GeneOntologyMolecularFunction	phenanthrene-epoxide hydrolase activity	AKR7A2 AKR7L AKR7A3	9.78e-08	3	93	3	GO:0019118
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE2A PDE3A PDE6C PDE6B PDE5A	1.46e-07	27	93	5	GO:0004112
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE2A PDE3A PDE6C PDE6B PLD3 PDE5A	6.09e-06	97	93	6	GO:0008081
GeneOntologyMolecularFunction	epoxide hydrolase activity	AKR7A2 AKR7L AKR7A3	1.57e-05	11	93	3	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	AKR7A2 AKR7L AKR7A3	2.70e-05	13	93	3	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	AKR7A2 AKR7L AKR7A3	2.70e-05	13	93	3	GO:0016803
GeneOntologyMolecularFunction	cyclic nucleotide binding	PDE2A PDE6C HCN3 PDE5A	3.20e-05	39	93	4	GO:0030551
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR7A2 AKR7L AKR7A3	3.43e-05	14	93	3	GO:0004032
GeneOntologyMolecularFunction	cGMP binding	PDE2A PDE6C PDE5A	5.24e-05	16	93	3	GO:0030553
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS1	6.42e-05	3	93	2	GO:0004829
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PDE2A PDE3A PDE6C PDE6B PLD3 PPEF1 PIKFYVE PTPRJ PDE5A	7.90e-05	386	93	9	GO:0042578
GeneOntologyMolecularFunction	transition metal ion binding	CYP1B1 PDE2A PRICKLE1 EXTL2 ADAMTS5 PPEF1 PIKFYVE TRIM67 PRICKLE3 TRIM9 AGMO PRICKLE2 ALAD PDZRN3 TARS1 DNMT1	1.12e-04	1189	93	16	GO:0046914
GeneOntologyMolecularFunction	O-methyltransferase activity	ASMTL TRMT13 FTSJ3	2.09e-04	25	93	3	GO:0008171
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR7A2 AKR7L AKR7A3	2.64e-04	27	93	3	GO:0008106
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR7A2 AKR7L AKR7A3	4.40e-04	32	93	3	GO:0004033
GeneOntologyMolecularFunction	RNA 2'-O-methyltransferase activity	TRMT13 FTSJ3	7.56e-04	9	93	2	GO:0062105
GeneOntologyMolecularFunction	zinc ion binding	PDE2A PRICKLE1 ADAMTS5 PIKFYVE TRIM67 PRICKLE3 TRIM9 PRICKLE2 ALAD PDZRN3 TARS1 DNMT1	8.67e-04	891	93	12	GO:0008270
GeneOntologyMolecularFunction	lipid kinase activity	DGKH PIKFYVE DGKK	9.17e-04	41	93	3	GO:0001727
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKH DGKK	1.15e-03	11	93	2	GO:0004143
GeneOntologyMolecularFunction	methyltransferase activity	ASMTL TRMT13 PRMT7 DNMT1 FTSJ3	3.20e-03	213	93	5	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	ASMTL TRMT13 PRMT7 DNMT1 FTSJ3	3.97e-03	224	93	5	GO:0016741
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	PDE2A PDE3A PDE6C PDE6B ACY3 PLD3 PPEF1 PIKFYVE PTPRJ PDE5A	4.31e-03	807	93	10	GO:0016788
GeneOntologyBiologicalProcess	regulation of brain-derived neurotrophic factor-activated receptor activity	FAM72D FAM72C FAM72A FAM72B	3.71e-10	4	92	4	GO:0031551
GeneOntologyBiologicalProcess	negative regulation of brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	1.85e-09	5	92	4	GO:0031549
GeneOntologyBiologicalProcess	regulation of brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	1.28e-08	7	92	4	GO:0031548
GeneOntologyBiologicalProcess	negative regulation of signaling receptor activity	FAM72D FAM72C PTPRJ FAM72A FAM72B	3.40e-07	33	92	5	GO:2000272
GeneOntologyBiologicalProcess	brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	3.59e-07	14	92	4	GO:0031547
GeneOntologyBiologicalProcess	negative regulation of protein tyrosine kinase activity	FAM72D FAM72C FAM72A FAM72B	9.29e-06	30	92	4	GO:0061099
GeneOntologyBiologicalProcess	cAMP-mediated signaling	PDE2A PDE3A PDE6C PDE6B PDE5A	2.28e-05	76	92	5	GO:0019933
GeneOntologyBiologicalProcess	regulation of signaling receptor activity	FAM72D FAM72C ADRB2 PTPRJ FAM72A FAM72B	2.67e-05	131	92	6	GO:0010469
GeneOntologyBiologicalProcess	positive regulation of oocyte development	PDE3A PDE5A	5.89e-05	3	92	2	GO:0060282
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS1	5.89e-05	3	92	2	GO:0006435
GeneOntologyBiologicalProcess	phototransduction, visible light	PDE6C PDE6B AIPL1	9.27e-05	20	92	3	GO:0007603
GeneOntologyBiologicalProcess	regulation of postsynaptic density assembly	PRICKLE1 LRRTM1 PRICKLE2	1.08e-04	21	92	3	GO:0099151
GeneOntologyBiologicalProcess	regulation of oocyte development	PDE3A PDE5A	1.17e-04	4	92	2	GO:0060281
GeneOntologyBiologicalProcess	regulation of oogenesis	PDE3A PDE5A	1.17e-04	4	92	2	GO:1905879
GeneOntologyBiologicalProcess	negative regulation of peptidyl-tyrosine phosphorylation	FAM72D FAM72C FAM72A FAM72B	1.40e-04	59	92	4	GO:0050732
GeneOntologyBiologicalProcess	chronic inflammatory response	UNC13D PDE5A LTA	1.84e-04	25	92	3	GO:0002544
GeneOntologyBiologicalProcess	positive regulation of chronic inflammatory response	PDE5A LTA	1.95e-04	5	92	2	GO:0002678
GeneOntologyBiologicalProcess	cGMP catabolic process	PDE2A PDE5A	1.95e-04	5	92	2	GO:0046069
GeneOntologyBiologicalProcess	regulation of postsynaptic specialization assembly	PRICKLE1 LRRTM1 PRICKLE2	2.07e-04	26	92	3	GO:0099150
GeneOntologyBiologicalProcess	regulation of excitatory synapse assembly	PRICKLE1 LRRTM1 PRICKLE2	2.07e-04	26	92	3	GO:1904889
GeneOntologyBiologicalProcess	regulation of peptidyl-tyrosine phosphorylation	FAM72D FAM72C PTPRJ FAM72A KIT FAM72B IL9R	2.16e-04	272	92	7	GO:0050730
GeneOntologyBiologicalProcess	regulation of postsynaptic density organization	PRICKLE1 LRRTM1 PRICKLE2	2.32e-04	27	92	3	GO:1905874
GeneOntologyBiologicalProcess	regulation of protein tyrosine kinase activity	FAM72D FAM72C FAM72A FAM72B	2.57e-04	69	92	4	GO:0061097
GeneOntologyBiologicalProcess	regulation of vascular permeability	PDE2A PDE3A PTPRJ HRH1	2.87e-04	71	92	4	GO:0043114
GeneOntologyBiologicalProcess	positive regulation of apoptotic process	CYP1B1 FAM72D FAM72C KLRK1 FZD9 ADRB2 FAM72A PDE5A LTA FAM72B NSMAF	3.49e-04	718	92	11	GO:0043065
GeneOntologyBiologicalProcess	cellular response to cGMP	PDE2A PDE3A	4.07e-04	7	92	2	GO:0071321
GeneOntologyBiologicalProcess	positive regulation of programmed cell death	CYP1B1 FAM72D FAM72C KLRK1 FZD9 ADRB2 FAM72A PDE5A LTA FAM72B NSMAF	4.45e-04	739	92	11	GO:0043068
GeneOntologyBiologicalProcess	negative regulation of vascular permeability	PDE2A PDE3A PTPRJ	4.65e-04	34	92	3	GO:0043116
GeneOntologyBiologicalProcess	postsynaptic density assembly	PRICKLE1 LRRTM1 PRICKLE2	4.65e-04	34	92	3	GO:0097107
GeneOntologyBiologicalProcess	membrane lipid metabolic process	CYP1B1 PIGB PIGG AGMO KIT NSMAF	5.65e-04	229	92	6	GO:0006643
GeneOntologyBiologicalProcess	peptidyl-tyrosine phosphorylation	FAM72D FAM72C PTPRJ FAM72A KIT FAM72B IL9R	6.53e-04	327	92	7	GO:0018108
GeneOntologyBiologicalProcess	peptidyl-tyrosine modification	FAM72D FAM72C PTPRJ FAM72A KIT FAM72B IL9R	6.77e-04	329	92	7	GO:0018212
GeneOntologyBiologicalProcess	response to cGMP	PDE2A PDE3A	6.94e-04	9	92	2	GO:0070305
GeneOntologyBiologicalProcess	maintenance of postsynaptic density structure	PRICKLE1 PRICKLE2	6.94e-04	9	92	2	GO:0099562
MousePheno	abnormal somatic hypermutation frequency	FAM72D FAM72C FAM72A FAM72B	2.94e-06	19	76	4	MP:0004815
MousePheno	increased B cell apoptosis	FAM72D FAM72C FAM72A FAM72B	1.50e-05	28	76	4	MP:0008782
MousePheno	increased germinal center B cell number	FAM72D FAM72C FAM72A FAM72B	2.27e-05	31	76	4	MP:0008177
MousePheno	abnormal class switch recombination	FAM72D FAM72C FAM72A LTA FAM72B	7.72e-05	81	76	5	MP:0004816
MousePheno	abnormal susceptibility to Herpesvirales infection	MBTPS1 HLA-E UNC13D TLR9 KLRK1	8.67e-05	83	76	5	MP:0020915
MousePheno	abnormal B cell apoptosis	FAM72D FAM72C FAM72A FAM72B	1.21e-04	47	76	4	MP:0008781
MousePheno	abnormal B cell differentiation	FAM72D FAM72C FZD9 PTPRJ FAM72A LTA KIT FAM72B	1.61e-04	287	76	8	MP:0002144
MousePheno	abnormal Muller cell morphology	PDE6B ADRB2 AIPL1	1.65e-04	20	76	3	MP:0005547
MousePheno	decreased neuron number	PDE6C PDE6B CACNA2D2 WDR81 HIPK2 ADRB2 AIPL1 KIT DNMT1	1.94e-04	376	76	9	MP:0008948
MousePheno	abnormal germinal center B cell number	FAM72D FAM72C FAM72A FAM72B	2.23e-04	55	76	4	MP:0013680
MousePheno	abnormal germinal center B cell morphology	FAM72D FAM72C FAM72A FAM72B	2.23e-04	55	76	4	MP:0008176
MousePheno	increased mature B cell number	FAM72D FAM72C PTPRJ FAM72A LTA FAM72B	3.01e-04	168	76	6	MP:0008210
Domain	FAM72	FAM72D FAM72C FAM72A FAM72B	5.76e-10	4	93	4	PF14976
Domain	FAM72	FAM72D FAM72C FAM72A FAM72B	5.76e-10	4	93	4	IPR026768
Domain	GAF	PDE2A PDE6C PDE6B PDE5A	1.99e-08	7	93	4	PF01590
Domain	GAF	PDE2A PDE6C PDE6B PDE5A	3.97e-08	8	93	4	IPR003018
Domain	GAF	PDE2A PDE6C PDE6B PDE5A	3.97e-08	8	93	4	SM00065
Domain	PDEase_I	PDE2A PDE3A PDE6C PDE6B PDE5A	5.25e-08	21	93	5	PF00233
Domain	PDEASE_I	PDE2A PDE3A PDE6C PDE6B PDE5A	5.25e-08	21	93	5	PS00126
Domain	PDEase_CS	PDE2A PDE3A PDE6C PDE6B PDE5A	5.25e-08	21	93	5	IPR023174
Domain	-	PDE2A PDE3A PDE6C PDE6B PDE5A	6.76e-08	22	93	5	1.10.1300.10
Domain	GAF_dom-like	PDE2A PDE6C PDE6B PDE5A	7.12e-08	9	93	4	IPR029016
Domain	-	PDE2A PDE6C PDE6B PDE5A	7.12e-08	9	93	4	3.30.450.40
Domain	PDEase_catalytic_dom	PDE2A PDE3A PDE6C PDE6B PDE5A	8.61e-08	23	93	5	IPR002073
Domain	HDc	PDE2A PDE3A PDE6C PDE6B PDE5A	1.08e-07	24	93	5	SM00471
Domain	HD/PDEase_dom	PDE2A PDE3A PDE6C PDE6B PDE5A	1.08e-07	24	93	5	IPR003607
Domain	LIM3_prickle	PRICKLE1 PRICKLE3 PRICKLE2	1.20e-07	3	93	3	IPR033727
Domain	LIM2_prickle	PRICKLE1 PRICKLE3 PRICKLE2	1.20e-07	3	93	3	IPR033726
Domain	PET_prickle	PRICKLE1 PRICKLE3 PRICKLE2	1.20e-07	3	93	3	IPR033723
Domain	PDEase	PDE2A PDE6C PDE6B PDE5A	2.11e-06	19	93	4	IPR023088
Domain	PET	PRICKLE1 PRICKLE3 PRICKLE2	2.36e-06	6	93	3	PF06297
Domain	PET_domain	PRICKLE1 PRICKLE3 PRICKLE2	2.36e-06	6	93	3	IPR010442
Domain	PET	PRICKLE1 PRICKLE3 PRICKLE2	2.36e-06	6	93	3	PS51303
Domain	LIM1_prickle	PRICKLE3 PRICKLE2	2.45e-05	2	93	2	IPR033725
Domain	SV2	SV2B SV2A	7.33e-05	3	93	2	IPR022308
Domain	ThrRS_core	TARS3 TARS1	7.33e-05	3	93	2	IPR033728
Domain	Pentapeptide_4	SV2B SV2A	7.33e-05	3	93	2	PF13599
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS1	7.33e-05	3	93	2	IPR002320
Domain	NADP_OxRdtase_dom	AKR7A2 AKR7L AKR7A3	7.73e-05	17	93	3	IPR023210
Domain	Aldo_ket_red	AKR7A2 AKR7L AKR7A3	7.73e-05	17	93	3	PF00248
Domain	Aldo/ket_red/Kv-b	AKR7A2 AKR7L AKR7A3	7.73e-05	17	93	3	IPR001395
Domain	5peptide_repeat	SV2B SV2A	1.46e-04	4	93	2	IPR001646
Domain	GLYCOSYL_HYDROL_F31_2	MGAM MYORG	2.43e-04	5	93	2	PS00707
Domain	TGS	TARS3 TARS1	3.63e-04	6	93	2	IPR004095
Domain	TGS	TARS3 TARS1	3.63e-04	6	93	2	PF02824
Domain	Glyco_hydro_31	MGAM MYORG	5.07e-04	7	93	2	IPR000322
Domain	TGS-like	TARS3 TARS1	5.07e-04	7	93	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS1	5.07e-04	7	93	2	SM00863
Domain	tRNA_SAD	TARS3 TARS1	5.07e-04	7	93	2	IPR012947
Domain	Glyco_hydro_31	MGAM MYORG	5.07e-04	7	93	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM MYORG	5.07e-04	7	93	2	PS00129
Domain	tRNA_SAD	TARS3 TARS1	5.07e-04	7	93	2	PF07973
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS1	6.74e-04	8	93	2	IPR018163
Domain	BEACH_dom	WDR81 NSMAF	8.63e-04	9	93	2	IPR000409
Domain	BEACH	WDR81 NSMAF	8.63e-04	9	93	2	PS50197
Domain	Beach	WDR81 NSMAF	8.63e-04	9	93	2	PF02138
Domain	-	WDR81 NSMAF	8.63e-04	9	93	2	1.10.1540.10
Domain	Beach	WDR81 NSMAF	8.63e-04	9	93	2	SM01026
Domain	HGTP_anticodon	TARS3 TARS1	8.63e-04	9	93	2	PF03129
Domain	DAGK_acc	DGKH DGKK	1.08e-03	10	93	2	PF00609
Domain	Diacylglycerol_kin_accessory	DGKH DGKK	1.08e-03	10	93	2	IPR000756
Domain	DAGKa	DGKH DGKK	1.08e-03	10	93	2	SM00045
Domain	aa-tRNA-synt_IIb	TARS3 TARS1	1.31e-03	11	93	2	IPR002314
Domain	tRNA-synt_2b	TARS3 TARS1	1.31e-03	11	93	2	PF00587
Domain	-	TARS3 TARS1	1.31e-03	11	93	2	3.40.50.800
Domain	COS_domain	TRIM67 TRIM9	1.57e-03	12	93	2	IPR017903
Domain	COS	TRIM67 TRIM9	1.57e-03	12	93	2	PS51262
Domain	Beta-grasp_dom	TARS3 TARS1	2.15e-03	14	93	2	IPR012675
Domain	-	TARS3 TARS1	2.15e-03	14	93	2	3.10.20.30
Domain	Anticodon-bd	TARS3 TARS1	2.15e-03	14	93	2	IPR004154
Domain	DAGKc	DGKH DGKK	2.15e-03	14	93	2	SM00046
Domain	Bbox_C	TRIM67 TRIM9	2.47e-03	15	93	2	IPR003649
Domain	Diacylglycerol_kinase_cat_dom	DGKH DGKK	2.47e-03	15	93	2	IPR001206
Domain	BBC	TRIM67 TRIM9	2.47e-03	15	93	2	SM00502
Domain	DAGK_cat	DGKH DGKK	2.47e-03	15	93	2	PF00781
Domain	DAGK	DGKH DGKK	2.47e-03	15	93	2	PS50146
Domain	-	AKR7A2 AKR7A3	2.81e-03	16	93	2	3.20.20.100
Domain	-	ASMTL PRMT7 DNMT1 FTSJ3	3.05e-03	120	93	4	3.40.50.150
Domain	Gal_mutarotase_SF_dom	MGAM MAN2A2	3.18e-03	17	93	2	IPR011013
Domain	NAD/diacylglycerol_kinase	DGKH DGKK	3.18e-03	17	93	2	IPR016064
Domain	SAM-dependent_MTases	ASMTL PRMT7 DNMT1 FTSJ3	3.23e-03	122	93	4	IPR029063
Domain	Iontro_rcpt	GRID1 GRIK4	3.56e-03	18	93	2	IPR001320
Domain	Lig_chan-Glu_bd	GRID1 GRIK4	3.56e-03	18	93	2	PF10613
Domain	aa-tRNA-synth_II	TARS3 TARS1	3.56e-03	18	93	2	IPR006195
Domain	Iono_rcpt_met	GRID1 GRIK4	3.56e-03	18	93	2	IPR001508
Domain	Glu/Gly-bd	GRID1 GRIK4	3.56e-03	18	93	2	IPR019594
Domain	Lig_chan-Glu_bd	GRID1 GRIK4	3.56e-03	18	93	2	SM00918
Domain	Lig_chan	GRID1 GRIK4	3.56e-03	18	93	2	PF00060
Domain	PBPe	GRID1 GRIK4	3.56e-03	18	93	2	SM00079
Domain	AA_TRNA_LIGASE_II	TARS3 TARS1	3.56e-03	18	93	2	PS50862
Domain	LIM	PRICKLE1 PRICKLE3 PRICKLE2	4.94e-03	69	93	3	PF00412
Pathway	REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION	ACY3 AKR7A2 AKR7L AKR7A3	2.29e-06	19	72	4	M27449
Pathway	WP_AFLATOXIN_B1_METABOLISM	AKR7A2 AKR7L AKR7A3	2.53e-06	6	72	3	MM15846
Pathway	REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION	ACY3 AKR7A2 AKR7L AKR7A3	8.59e-06	26	72	4	MM15190
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE2A PDE3A PDE6C PDE6B PDE5A	8.61e-06	55	72	5	M39763
Pathway	REACTOME_TOXICITY_OF_BOTULINUM_TOXIN_TYPE_D_BOTD	SV2B SV2A	2.55e-04	5	72	2	M27427
Pubmed	Fam72a enforces error-prone DNA repair during antibody diversification.	FAM72D FAM72C FAM72A FAM72B	5.68e-11	4	97	4	34819671
Pubmed	Identification and characterisation of the novel amyloid-beta peptide-induced protein p17.	FAM72D FAM72C FAM72A FAM72B	2.84e-10	5	97	4	19755123
Pubmed	All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci.	FAM72D FAM72C FAM72A FAM72B	2.84e-10	5	97	4	26206078
Pubmed	FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.	FAM72D FAM72C FAM72A FAM72B	8.49e-10	6	97	4	34819670
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE2A PDE3A PDE6C PDE6B PDE5A	2.99e-09	21	97	5	27740716
Pubmed	Overview of PDEs and their regulation.	PDE2A PDE3A PDE6C PDE6B PDE5A	7.73e-09	25	97	5	17307970
Pubmed	[Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].	AKR7A2 AKR7L AKR7A3	2.10e-08	3	97	3	22863590
Pubmed	Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.	AKR7A2 AKR7L AKR7A3	2.10e-08	3	97	3	12123834
Pubmed	Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.	AKR7A2 AKR7L AKR7A3	2.10e-08	3	97	3	24590062
Pubmed	Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.	AKR7A2 AKR7L AKR7A3	2.10e-08	3	97	3	12071861
Pubmed	Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.	AKR7A2 AKR7L AKR7A3	2.10e-08	3	97	3	16919859
Pubmed	AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.	AKR7A2 AKR7L AKR7A3	2.10e-08	3	97	3	39365156
Pubmed	The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.	HLA-E AKR7A2 AKR7L AKR7A3	2.77e-08	12	97	4	10495887
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE2A PDE3A PDE6B PDE5A	3.99e-08	13	97	4	8557689
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE2A PDE3A ADRB2 PDE5A	5.57e-08	14	97	4	25852085
Pubmed	cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.	FAM72D FAM72C FAM72A FAM72B	7.58e-08	15	97	4	1741163
Pubmed	Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.	AKR7A2 AKR7L AKR7A3	8.40e-08	4	97	3	12879023
Pubmed	Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.	PDE6C PDE6B PDE5A	8.40e-08	4	97	3	23033484
Pubmed	Migration and synaptogenesis of cone photoreceptors in the developing mouse retina.	PDE6B SV2B SV2A	7.30e-07	7	97	3	9364238
Pubmed	SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.	SV2B SV2A	7.70e-06	2	97	2	19176798
Pubmed	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.	TARS3 TARS1	7.70e-06	2	97	2	37059185
Pubmed	Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.	PDE2A PDE3A	7.70e-06	2	97	2	26095046
Pubmed	Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.	PDE6C PDE6B	7.70e-06	2	97	2	26085644
Pubmed	Synaptic vesicle protein 2 binds adenine nucleotides.	SV2B SV2A	7.70e-06	2	97	2	18524768
Pubmed	Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells.	PRICKLE1 PRICKLE2	7.70e-06	2	97	2	22218901
Pubmed	Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle.	PRICKLE1 PRICKLE2	7.70e-06	2	97	2	12525887
Pubmed	The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.	KIT DNMT1	7.70e-06	2	97	2	26085088
Pubmed	Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.	SV2B SV2A	7.70e-06	2	97	2	18815274
Pubmed	Mutations in prickle orthologs cause seizures in flies, mice, and humans.	PRICKLE1 PRICKLE2	7.70e-06	2	97	2	21276947
Pubmed	Brain contains two forms of synaptic vesicle protein 2.	SV2B SV2A	7.70e-06	2	97	2	7681585
Pubmed	Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity.	TLR9 PIKFYVE	7.70e-06	2	97	2	25925170
Pubmed	Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.	PDE6C PDE6B	7.70e-06	2	97	2	30038560
Pubmed	A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.	TARS3 TARS1	7.70e-06	2	97	2	29579307
Pubmed	SV2 mediates entry of tetanus neurotoxin into central neurons.	SV2B SV2A	7.70e-06	2	97	2	21124874
Pubmed	Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.	PRICKLE1 PRICKLE2	7.70e-06	2	97	2	34613779
Pubmed	Calcium dynamics change in degenerating cone photoreceptors.	PDE6C PDE6B	7.70e-06	2	97	2	27402880
Pubmed	Diacylglycerol kinase K variants impact hypospadias in a California study population.	DGKH DGKK	7.70e-06	2	97	2	23177175
Pubmed	A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.	KIT DNMT1	7.70e-06	2	97	2	28869603
Pubmed	Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth.	PRICKLE1 PRICKLE2	7.70e-06	2	97	2	17868671
Pubmed	SV2 regulates neurotransmitter release via multiple mechanisms.	SV2B SV2A	7.70e-06	2	97	2	20702688
Pubmed	Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases.	PDE2A PDE3A	7.70e-06	2	97	2	12038792
Pubmed	Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration.	PDE6C PDE6B	7.70e-06	2	97	2	31710697
Pubmed	Synaptic vesicle protein 2 enhances release probability at quiescent synapses.	SV2B SV2A	7.70e-06	2	97	2	16436618
Pubmed	The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells.	PDE6B AIPL1	7.70e-06	2	97	2	20042464
Pubmed	Down-regulation of histamine H1 receptors by beta2-adrenoceptor-mediated inhibition of H1 receptor gene transcription.	ADRB2 HRH1	7.70e-06	2	97	2	18498711
Pubmed	Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.	SV2B SV2A	7.70e-06	2	97	2	22847229
Pubmed	Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A).	SV2B SV2A	7.70e-06	2	97	2	10611374
Pubmed	SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release.	SV2B SV2A	7.70e-06	2	97	2	10624962
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	PRICKLE1 FZD9 PRICKLE3 PRICKLE2	9.25e-06	47	97	4	33141892
Pubmed	Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.	SV2B SV2A	2.31e-05	3	97	2	23617838
Pubmed	Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation.	KIT IL9R	2.31e-05	3	97	2	37172907
Pubmed	Beta2-adrenoceptor stimulation suppresses TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells.	TLR9 ADRB2	2.31e-05	3	97	2	23724117
Pubmed	RETINAL DEGENERATION IN THE MOUSE: LOCATION OF THE RD LOCUS IN LINKAGE GROUP XVII.	PDE6B KIT	2.31e-05	3	97	2	14276177
Pubmed	Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.	PRICKLE1 PRICKLE2	2.31e-05	3	97	2	22037766
Pubmed	Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.	PDE2A PDE3A	2.31e-05	3	97	2	17704206
Pubmed	Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client.	PDE6C AIPL1	2.31e-05	3	97	2	27268253
Pubmed	Expression of SV2 isoforms during rodent brain development.	SV2B SV2A	2.31e-05	3	97	2	23937191
Pubmed	Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles.	SV2B SV2A	2.31e-05	3	97	2	26015569
Pubmed	Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.	HRH1 KIT	2.31e-05	3	97	2	29812984
Pubmed	Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.	SV2B SV2A	2.31e-05	3	97	2	33588752
Pubmed	The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.	LTA KIT	2.31e-05	3	97	2	22901752
Pubmed	Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice.	HRH1 KIT	2.31e-05	3	97	2	12644274
Pubmed	A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis.	KIT IL9R	2.31e-05	3	97	2	28090087
Pubmed	Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses.	UNC13D TLR9	2.31e-05	3	97	2	26680738
Pubmed	A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome.	PRICKLE1 PRICKLE2	2.31e-05	3	97	2	18976727
Pubmed	Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans.	PDE2A PDE3A	2.31e-05	3	97	2	19252089
Pubmed	Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea.	PDE6B KIT	2.31e-05	3	97	2	17600127
Pubmed	Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells.	PRICKLE1 PRICKLE2	2.31e-05	3	97	2	19788910
Pubmed	No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.	SV2B SV2A	2.31e-05	3	97	2	18977120
Pubmed	Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis.	HRH1 KIT	2.31e-05	3	97	2	23922690
Pubmed	SV2 is the protein receptor for botulinum neurotoxin A.	SV2B SV2A	2.31e-05	3	97	2	16543415
Pubmed	Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina.	SV2B SV2A	2.31e-05	3	97	2	12687700
Pubmed	SV2 modulates the size of the readily releasable pool of secretory vesicles.	SV2B SV2A	2.31e-05	3	97	2	11483953
Pubmed	Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).	PDE3A KIT	2.31e-05	3	97	2	28454120
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	AKR7A2 AKR7L AKR7A3	2.32e-05	20	97	3	9828140
Pubmed	Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.	PDE6C PDE6B	4.60e-05	4	97	2	31825309
Pubmed	Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5).	PDE2A PDE5A	4.60e-05	4	97	2	21697861
Pubmed	Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.	SV2B SV2A	4.60e-05	4	97	2	23894296
Pubmed	IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut.	KIT IL9R	4.60e-05	4	97	2	29742432
Pubmed	Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status.	TLR9 DNMT1	4.60e-05	4	97	2	24459426
Pubmed	Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas deferens.	SV2B SV2A	4.60e-05	4	97	2	11668586
Pubmed	Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.	PDE2A PDE5A	4.60e-05	4	97	2	15938621
Pubmed	AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly.	PDE6B AIPL1	4.60e-05	4	97	2	19758987
Pubmed	Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.	TLR9 DNMT1	4.60e-05	4	97	2	28459195
Pubmed	Mast cells enhance T cell activation: Importance of mast cell-derived TNF.	LTA KIT	4.60e-05	4	97	2	15840716
Pubmed	Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase.	PRICKLE1 PRICKLE2	4.60e-05	4	97	2	25763846
Pubmed	Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.	PRICKLE1 PRICKLE2	4.60e-05	4	97	2	35420656
Pubmed	C57BL-6J mice with inherited retinal degeneration.	PDE6B KIT	4.60e-05	4	97	2	4595403
Pubmed	Cotrafficking of SV2 and synaptotagmin at the synapse.	SV2B SV2A	4.60e-05	4	97	2	20410110
Pubmed	Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium.	PRICKLE1 PRICKLE2	4.60e-05	4	97	2	36176272
Pubmed	Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner.	PDE2A PDE5A	4.60e-05	4	97	2	16150726
Pubmed	Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.	PDE6C PDE6B	4.60e-05	4	97	2	21799013
Pubmed	Towards complete sets of farnesylated and geranylgeranylated proteins.	PRICKLE1 PRICKLE2	4.60e-05	4	97	2	17411337
Pubmed	Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression.	PDE2A PDE5A	4.60e-05	4	97	2	14687666
Pubmed	Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis.	SV2B SV2A	4.60e-05	4	97	2	37738980
Pubmed	A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance.	TRIM67 TRIM9	4.60e-05	4	97	2	31820781
Pubmed	Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma.	ADRB2 LTA	7.66e-05	5	97	2	11258696
Pubmed	TLR9 Regulates the NF-κB-NLRP3-IL-1β Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal Inflammation.	TLR9 KLRK1	7.66e-05	5	97	2	28576980
Pubmed	Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system.	SV2B SV2A	7.66e-05	5	97	2	12172780
Pubmed	Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis.	CS SDHD	7.66e-05	5	97	2	17298551
Interaction	PDE5A interactions	PDE3A PDE6C AIPL1 PDE5A	2.03e-06	20	94	4	int:PDE5A
Cytoband	1p36.13	AKR7A2 AKR7L AKR7A3	2.34e-04	56	97	3	1p36.13
GeneFamily	Phosphodiesterases	PDE2A PDE3A PDE6C PDE6B PDE5A	2.81e-08	24	69	5	681
GeneFamily	Prickle planar cell polarity proteins\|LIM domain containing	PRICKLE1 PRICKLE3 PRICKLE2	2.12e-07	4	69	3	1184
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDR81 NSMAF	5.08e-04	9	69	2	1230
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKH DGKK	6.33e-04	10	69	2	1178
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TLR9 KLRK1 FZD9 PTPRJ CD58 KIT IL9R	7.47e-04	394	69	7	471
GeneFamily	Aldo-keto reductases	AKR7A2 AKR7A3	1.46e-03	15	69	2	399
GeneFamily	LIM domain containing	PRICKLE1 PRICKLE3 PRICKLE2	1.48e-03	59	69	3	1218
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGB PIGG	2.88e-03	21	69	2	680
Coexpression	GSE6259_33D1_POS_VS_DEC205_POS_SPLENIC_DC_DN	CYP1B1 HIPK2 EXTL2 PTPRJ ZBTB21 KIT SECTM1	6.91e-06	198	93	7	M6731
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE3A HIPK2 TRIM9 PRICKLE2 HRH1 PDZRN3	2.94e-06	182	97	6	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE2A PDE3A GRID1 DGKH ADAMTS5 PDE5A	3.43e-06	187	97	6	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Cxcl14_(dSPN,_lateral_striatum)\|Striatum / BrainAtlas - Mouse McCarroll V32	MGAM PDE6B FABP6 IL9R	9.02e-06	60	97	4	64d4de1de20d07c5f2e20b76854311a31718faa4
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Cxcl14_(dSPN,_lateral_striatum)-\|Striatum / BrainAtlas - Mouse McCarroll V32	MGAM PDE6B FABP6 IL9R	9.02e-06	60	97	4	b3941f8c3cf2365c5bf79961f62c9c0c7405a67b
ToppCell	Severe-Lymphoid-NK-Proliferating_T\|Severe / Condition, Lineage, Cell class and cell subclass	ACY3 KLRK1 TARS3 NLE1 ADGRF3	2.64e-05	160	97	5	cb2276d9bd78508644420e9580d3c17b914224cb
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAQR4 FZD9 PTPRJ KIT NEURL4	3.06e-05	165	97	5	34fd00be2b28716c871ad9fb356de84a299a0c01
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A DGKH ADAMTS5 HECTD2 PRICKLE2	3.44e-05	169	97	5	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	DIP2C-AS1 ACY3 ODAD4 AKR7L AKR7A3	3.53e-05	170	97	5	d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FAM72D FAM72C FAM72B IL9R TLCD5	3.63e-05	171	97	5	4ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 PDE6B TLR9 PTPRJ CFAP44	3.84e-05	173	97	5	e944ea3a0a368f856efacbda4600605cf751dd9c
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 PDE6B TLR9 PTPRJ CFAP44	3.84e-05	173	97	5	85fa5918e9c1f6bb4757e3350cfc71ee75c55640
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAQR4 TLR9 FZD9 PTPRJ KIT	4.52e-05	179	97	5	906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCell	wk_15-18-Epithelial-PNS-KCNIP4+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBX22 PPEF1 TRIM67 TRIM9 DLX6	4.52e-05	179	97	5	e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PDE3A CACNA2D2 ADRB2 KIT IL9R	4.76e-05	181	97	5	f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell	cellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE6B CACNA2D2 KLRK1 ADRB2 DGKK	4.89e-05	182	97	5	8ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FAM72C PRICKLE1 MYORG FZD9 TRIM9	4.89e-05	182	97	5	00a148b1e499bf16325491536d187d4dd6b70c06
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM72D FAM72C FAM72B IL9R TLCD5	5.02e-05	183	97	5	f03d87b556a3d50360d4eb6126b3466fe7266677
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE3A ADRB2 SV2A ZBTB21 CD58	5.28e-05	185	97	5	b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE3A ADRB2 SV2A ZBTB21 CD58	5.28e-05	185	97	5	d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCell	IIH-NK\|IIH / Condition, Cell_class and T cell subcluster	GRIK4 KLRK1 LIM2 ADRB2 KIT	5.42e-05	186	97	5	cab1249b849013cf0334f25ee8d840f0521f4eb8
ToppCell	IIH-NK-\|IIH / Condition, Cell_class and T cell subcluster	GRIK4 KLRK1 LIM2 ADRB2 KIT	5.42e-05	186	97	5	2c90b45c8ccfd86bbf6840dba7f0d7f08b5ea914
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	PRICKLE1 GRIK4 TRIM9 PDE5A PDZRN3	5.56e-05	187	97	5	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRIK4 ADAMTS5 MYORG TRIM67 PDZRN3	5.56e-05	187	97	5	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRIK4 ADAMTS5 MYORG TRIM67 PDZRN3	5.56e-05	187	97	5	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	5.85e-05	189	97	5	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A DGKH ADRB2 PRICKLE2 KIT	6.30e-05	192	97	5	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.30e-05	192	97	5	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A CACNA2D2 SV2A DLX6 KIT	6.46e-05	193	97	5	9f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.46e-05	193	97	5	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.46e-05	193	97	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	ASK440-Epithelial-Ciliated\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.46e-05	193	97	5	a0baa8be6f590b2031fede22be588715ae458e93
ToppCell	(07)_Brush\|World / shred by cell type and Timepoint	PDE2A CACNA2D2 ADGRF3 KIT PDZRN3	6.46e-05	193	97	5	9af9d22a130ff97a9c37142a65e841b056d08640
ToppCell	ASK440-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.61e-05	194	97	5	c84a7fa94fb06e08aae04db56c8c313b0afde1d7
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A CACNA2D2 TRIM67 DLX6 KIT	6.61e-05	194	97	5	4f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.78e-05	195	97	5	0e763f36786515698b593e5c93f6a56619c1242d
ToppCell	tumor_Lung-B_lymphocytes-GC_B_cells_in_the_DZ\|B_lymphocytes / Location, Cell class and cell subclass	FAM72D FAM72C ACY3 PAQR4 DNMT1	6.78e-05	195	97	5	339e81a3a5b1f71c0d15ef1ef0f6999378704923
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.78e-05	195	97	5	581b04220587e1d5198b1abd6965965ace7803e7
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.78e-05	195	97	5	93b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	6.78e-05	195	97	5	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_NK-NK_CD16\|lymph-node_spleen / Manually curated celltypes from each tissue	MGAM KLRK1 LIM2 ADRB2 DGKK	6.94e-05	196	97	5	f7e5a7fad4547e8ab9ab8b140239281832fb4260
ToppCell	Enterocyte\|World / shred on cell type and cluster	MGAM ACY3 FABP6 AKR7A3 SECTM1	7.11e-05	197	97	5	1dd980fd066aef21694395a4b69df938501d9631
ToppCell	CV-Moderate-3\|CV / Virus stimulation, Condition and Cluster	HLA-E PAQR4 LIM2 DNMT1 IL9R	7.11e-05	197	97	5	7031286e300eaccf73b927939f8de3a9d2d5fc74
ToppCell	(4)_B_cells-(4)_B_Hypermutation\|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	FAM72D FAM72C ACY3 PAQR4 DNMT1	7.28e-05	198	97	5	8be724a49b4c911d68c3e82fb75e96722d0eaa03
ToppCell	C_01\|World / shred on cell type and cluster	MGAM ACY3 FABP6 AKR7A3 SECTM1	7.28e-05	198	97	5	71d38084d09a96331877384ce6346f0de4bdcef9
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A UNC13D ADRB2 KIT IL9R	7.28e-05	198	97	5	cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_DZ\|B_lymphocytes / Location, Cell class and cell subclass	FAM72D FAM72C ACY3 PAQR4 DNMT1	7.28e-05	198	97	5	41e4bc7964a4895dd05bc62f0ef632ce9c89e34f
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A UNC13D ADRB2 KIT IL9R	7.28e-05	198	97	5	d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCell	proximal-Hematologic-Proliferating_NK/T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAM72D MGAM FAM72C PAQR4 FAM72B	7.28e-05	198	97	5	6c894fda309ec3d4bb446f63d5dde4e7f8c4fd89
ToppCell	proximal-3-Hematologic-Proliferating_NK/T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAM72D MGAM FAM72C PAQR4 FAM72B	7.28e-05	198	97	5	2777c5efe84ce3dbbe6175ecc1c987bc816ab74b
ToppCell	proximal-Hematologic-Proliferating_NK/T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAM72D MGAM FAM72C PAQR4 FAM72B	7.28e-05	198	97	5	2e121899f58a5024e26441bd326aac12c37fe6d1
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP1B1 PRICKLE1 AGMO HRH1 PDZRN3	7.46e-05	199	97	5	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAM72C PAQR4 FAM72A FAM72B SECTM1	7.46e-05	199	97	5	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	(1)_T_cell-(18)_cycling_gd_T\|(1)_T_cell / shred on Cell_type and subtype	FAM72D FAM72C PAQR4 GRIK4 FAM72B	7.46e-05	199	97	5	9369d0e4efe809e3e8757294ebebba5a47b30528
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	7.64e-05	200	97	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Mast_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A UNC13D ADRB2 KIT IL9R	7.64e-05	200	97	5	c3511607692e05f44538a376253673dd18f77908
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	7.64e-05	200	97	5	7cb3e3bd9e851ccb096e0a3471819471d85ebace
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial\|5w / Sample Type, Dataset, Time_group, and Cell type.	CYP1B1 PDE3A UNC13D LIM2 PDE5A	7.64e-05	200	97	5	69707f9576d326a06faac49701ef5cd632e760f6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial-Proteoglycan-expressing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	CYP1B1 PDE3A UNC13D LIM2 PDE5A	7.64e-05	200	97	5	f94381d0a3b5b81cdbb13b75fc0e4910cbd70382
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Mast_cell-Mast_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A UNC13D ADRB2 KIT IL9R	7.64e-05	200	97	5	1c58860932ed47263a5a537a64f0343201463c21
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DYNC2H1 ECT2L ODAD4 FABP6 CFAP44	7.64e-05	200	97	5	8441e289377215a6877640946fe3f6de1f456502
ToppCell	10x3'2.3-week_12-13-Myeloid_DC-DC-DC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ACY3 HCN3 SV2B AIPL1	2.35e-04	138	97	4	096c0c8ed396a27d29cca94e2e15099b64129c57
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TRIM67 PDE5A DLX6 KIT	2.42e-04	139	97	4	408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))--\|Thalamus / BrainAtlas - Mouse McCarroll V32	PDE6C KLRK1 AIPL1	2.61e-04	57	97	3	9614fe2acc6ee039383504f94bbe6d35aac27f25
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))\|Thalamus / BrainAtlas - Mouse McCarroll V32	PDE6C KLRK1 AIPL1	2.61e-04	57	97	3	309b3d48bfe215d7b581722c06d444b5b2ef6a30
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	PDE6C KLRK1 AIPL1	2.61e-04	57	97	3	3c55a5598a7ea789500f2fbd35c79d2b97a3fc7d
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKS6 FZD9 TARS3 ALAD	2.70e-04	143	97	4	b4ed3855652fdf32f97cb7c18cab4f4f4c24d5c7
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM67 PDE5A DLX6 KIT	2.77e-04	144	97	4	04f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACY3 SV2B DLX6 NPIPA2	2.99e-04	147	97	4	22d71cf92b957e5a8aa63b13157626d013d6752b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA2D2 ADRB2 LTA IL9R	3.40e-04	152	97	4	6aad62b5b5ad2f78c6600f37960338d40628a439
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CYP1B1 PRICKLE1 ADAMTS5 PPEF1	3.57e-04	154	97	4	511923b27469ea20f8bd82a9ec27119a6e884644
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM67 PDE5A DLX6 KIT	3.66e-04	155	97	4	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	PAQR4 PIGG NEURL4 TLCD5	3.66e-04	155	97	4	15bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCell	368C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DIP2C-AS1 PRICKLE1 FABP6 ALAD	3.75e-04	156	97	4	4877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	PDE3A DIP2C-AS1 KIT IL9R	3.75e-04	156	97	4	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-6\|TCGA-Kidney / Sample_Type by Project: Shred V9	FAM72D FAM72C FAM72A FAM72B	3.75e-04	156	97	4	d249747c7108a0edfc72d24c09b0b0e4ed662b40
ToppCell	368C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DIP2C-AS1 PRICKLE1 FABP6 ALAD	3.75e-04	156	97	4	1d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	PDE3A DIP2C-AS1 KIT IL9R	3.75e-04	156	97	4	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	HCN3 TRIM67 DLX6 KIT	4.03e-04	159	97	4	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	Ciliated_cells-A-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	TBX22 ECT2L ODAD4 FABP6	4.03e-04	159	97	4	0c65ae6140abd48c79b04758a6217709ddd15385
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-7\|TCGA-Cervix / Sample_Type by Project: Shred V9	DIP2C-AS1 ACY3 AKR7L AKR7A3	4.03e-04	159	97	4	75a82bbabd97b168dbf1c3f43a9bdad48ce18c78
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PDE2A MAN2A2 FZD9 KIT	4.13e-04	160	97	4	19105debef96ea0c267d6a1d332303ec668ae47e
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS5 KLRK1 LIM2 TRIM9	4.13e-04	160	97	4	8590281165eab6514a9f6a022b900d4c222c1044
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CYP1B1 GRIK4 PDE5A KIT	4.23e-04	161	97	4	3b5d7a3dab479c6959a428f3954dedd989900276
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PTPRJ PDE5A TRMT13 CFAP44	4.32e-04	162	97	4	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PTPRJ PDE5A TRMT13 CFAP44	4.32e-04	162	97	4	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAM72D FAM72C OVOS2 FAM72B	4.53e-04	164	97	4	ad508f53009efdd1dae7abcdb5431387f3f7e7b2
ToppCell	C_02\|World / shred on cell type and cluster	MGAM OVOS2 FABP6 AKR7A3	4.63e-04	165	97	4	a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ToppCell	critical-Myeloid-Mast_cell\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PDE3A CACNA2D2 KIT IL9R	4.63e-04	165	97	4	34a1cc6ccd46c059354e8fbde1ac69f202695a4e
ToppCell	lung-Ciliated_Epithelia\|lung / shred on tissue and cell subclass	DYNC2H1 ECT2L ODAD4 CFAP44	4.85e-04	167	97	4	26cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	FAM72D FAM72C FAM72B IL9R	4.85e-04	167	97	4	315cde87eed2b42a1b9b068fae94caa10ec64c70
ToppCell	NS-critical-d_07-13-Myeloid-Mast_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PDE3A CACNA2D2 KIT IL9R	4.85e-04	167	97	4	8a14fd980d8ebe8ef0216221f619d31aaa27ff15
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	HCN3 TRIM67 PDE5A DLX6	4.85e-04	167	97	4	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3A OR52I1 PDE5A KIT	4.96e-04	168	97	4	e40a3f85be7e9bb23bfbc1f9cb5e5fc54bb43863
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CYP1B1 GRIK4 PDE5A KIT	4.96e-04	168	97	4	f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE3A OR52I1 PDE5A KIT	4.96e-04	168	97	4	b1d6c35a5ae69c8638afd68c2be5bc9ce6fd2659
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	DIP2C-AS1 ACY3 AKR7L AKR7A3	5.30e-04	171	97	4	1af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAM72C ACY3 LTA IGHV3-64	5.42e-04	172	97	4	172e3c78f8e97988a4fd8624514e731282ddc16d
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PDE2A ACY3 DLX6 KIT	5.42e-04	172	97	4	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAM72C ACY3 LTA IGHV3-64	5.42e-04	172	97	4	5fb0ea6145892a258696197b3feed9760187e712
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAM72C ACY3 LTA IGHV3-64	5.42e-04	172	97	4	2214cc37d7c21b868768d3f74ca4631d339d37b3
Drug	dyphylline	PDE2A PDE3A PDE6B ADRB2 PDE5A	2.46e-07	33	95	5	CID000003182
Drug	glycerol-3-phosphocholine	MGAM PDE2A PDE3A PDE6C PDE6B PLD3 AKR7A2 PDE5A	6.26e-07	172	95	8	CID000000823
Drug	CI-930	PDE2A PDE3A PDE6B PDE5A	1.31e-06	20	95	4	CID003021728
Drug	AA-2379	PDE2A PDE3A PDE6B PDE5A	1.61e-06	21	95	4	CID000128390
Drug	HWA 153	PDE2A PDE3A PDE6B PDE5A	1.96e-06	22	95	4	CID000162797
Drug	griseolic acid	PDE2A PDE3A PDE6B PDE5A	2.37e-06	23	95	4	CID000127607
Drug	atherosperminine	PDE2A PDE3A PDE6B PDE5A	2.37e-06	23	95	4	CID000096918
Drug	desethyl KBT-3022	PDE2A PDE3A PDE6B PDE5A	3.96e-06	26	95	4	CID000127736
Drug	T-440	PDE2A PDE3A PDE6B PDE5A	3.96e-06	26	95	4	CID000177965
Drug	Ro 15-2041	PDE2A PDE3A PDE6B PDE5A	3.96e-06	26	95	4	CID000132434
Drug	P-NE	PDE2A PDE3A PDE6C PDE6B ADRB2 AIPL1 PDE5A	7.00e-06	169	95	7	CID000446755
Drug	PDEs	PDE2A PDE3A PDE6C PDE6B ADRB2 PDE5A	9.23e-06	116	95	6	CID003036959
Drug	imidazole-4-carboxamide	PDE2A PDE3A PDE6B PDE5A	9.35e-06	32	95	4	CID000152917
Drug	rolipram	PDE2A PDE3A PDE6B GRIK4 ADRB2 AIPL1 HRH1 PDE5A	1.10e-05	253	95	8	CID000005092
Drug	piroximone	PDE2A PDE3A ADRB2	1.51e-05	12	95	3	CID000055263
Drug	AH 21-132	PDE2A PDE3A PDE6B PDE5A	1.69e-05	37	95	4	CID003035793
Drug	zaprinast	PDE2A PDE3A PDE6C PDE6B ADRB2 PDE5A	2.80e-05	141	95	6	CID000005722
Drug	amrinone	PDE2A PDE3A ADRB2 PDE5A	3.10e-05	43	95	4	CID000003698
Drug	AC1LD8XI	PDE2A ADRB2 PDE5A	3.79e-05	16	95	3	CID000644287
Drug	milrinone	PDE2A PDE3A PDE6C PDE6B ADRB2 PDE5A	3.97e-05	150	95	6	CID000004197
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	PDE2A PDE3A CACNA2D2 HCN3 PIKFYVE HRH1 PDE5A NSMAF	4.49e-05	308	95	8	CID000001915
Drug	benzo(a)pyrene-1,6-quinone	CYP1B1 AKR7A2 AKR7A3	4.59e-05	17	95	3	ctd:C030233
Drug	U754	PDE2A ADRB2 PDE5A	4.59e-05	17	95	3	CID000062824
Drug	AC1L19O6	PDE2A PDE6C PDE6B AKR7A2 ADRB2 PDE5A	4.94e-05	156	95	6	CID000025750
Drug	N-formyl-L-aspartate	MGAM ACY3	5.15e-05	3	95	2	CID000088052
Drug	esmolol	MBTPS1 PDE3A ADRB2	5.49e-05	18	95	3	CID000059768
Drug	benzo(a)pyrene-7,8-dione	CYP1B1 AKR7A2 AKR7A3	7.62e-05	20	95	3	ctd:C076588
Drug	olprinone	PDE2A PDE3A ADRB2	7.62e-05	20	95	3	CID000004593
Drug	felodipine	CYP1B1 PDE2A PDE3A PDE6B CACNA2D2 PDE5A	7.71e-05	169	95	6	CID000003333
Drug	papaverine	PDE2A PDE3A PDE6C PDE6B CACNA2D2 PDE5A	9.64e-05	176	95	6	CID000004680
Drug	Ro-1724	PDE2A PDE3A PDE6B ADRB2 PDE5A	9.85e-05	110	95	5	CID000005087
Drug	siguazodan	PDE3A ADRB2 PDE5A	1.02e-04	22	95	3	CID000072124
Drug	cyclopropylurea	PDE3A PDE5A	1.03e-04	4	95	2	CID000272626
Drug	cyclooctylurea	PDE3A PDE5A	1.03e-04	4	95	2	CID000294524
Drug	succinic semialdehyde	AKR7A2 AKR7A3	1.03e-04	4	95	2	ctd:C009338
Drug	Tofisopam	PDE2A PDE3A	1.03e-04	4	95	2	DB08811
Drug	SureCN243145	MGAM ADRB2	1.03e-04	4	95	2	CID011446864
Drug	2-carboxybenzaldehyde	AKR7A2 AKR7L AKR7A3	1.17e-04	23	95	3	CID000008406
Drug	caffeine	CYP1B1 MGAM PDE2A PDE3A PDE6C PDE6B CACNA2D2 GRID1 GRIK4 PDE5A	1.19e-04	562	95	10	CID000002519
Drug	PDE I	PDE2A PDE3A PDE5A	1.34e-04	24	95	3	CID000198428
Drug	guanosine 3',5'-cyclic monophosphoric acid	CYP1B1 PDE2A PDE3A PDE6C PDE6B CACNA2D2 ADRB2 AIPL1 HRH1 PDE5A	1.48e-04	577	95	10	CID000000295
Drug	cilostamide	PDE2A PDE3A PDE6B ADRB2 PDE5A	1.48e-04	120	95	5	CID000002753
Drug	Lobelanidine hydrochloride [6112-86-3]; Up 200; 10.6uM; MCF7; HT_HG-U133A	MGAM PDE6C HIPK2 ADAMTS5 FABP6 ATG9A	1.69e-04	195	95	6	2897_UP
Drug	ilmenite	MGAM TRIM9	1.71e-04	5	95	2	CID000159436
Drug	T-0156	PDE6B PDE5A	1.71e-04	5	95	2	CID000005368
Drug	pyrimidine-2,4-dione	MGAM GRIK4	1.71e-04	5	95	2	CID000150747
Drug	4-chloro-3-nitrobenzaldehyde	AKR7A2 AKR7L	1.71e-04	5	95	2	CID000085505
Drug	8-pCPT-cGMP	PDE2A PDE3A HRH1 PDE5A	1.78e-04	67	95	4	CID000123969
Disease	unipolar depression, information processing speed, cognitive function measurement	PDE3A GRIK4 ADAMTS5 PTAR1	1.42e-05	47	92	4	EFO_0003761, EFO_0004363, EFO_0008354
Disease	X-24462 measurement	AKR7A2 AKR7A3	2.88e-05	3	92	2	EFO_0800886
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS1	5.75e-05	4	92	2	DOID:9252 (implicated_via_orthology)
Disease	cystic fibrosis (is_implicated_in)	TLR9 ADRB2 LTA	8.13e-05	27	92	3	DOID:1485 (is_implicated_in)
Disease	Opitz GBBB syndrome (implicated_via_orthology)	TRIM67 TRIM9	1.43e-04	6	92	2	DOID:0080697 (implicated_via_orthology)
Disease	retinal degeneration (implicated_via_orthology)	PDE6C PDE6B CS	1.50e-04	33	92	3	DOID:8466 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	CACNA2D2 PRICKLE1 PRICKLE3 SV2A PRICKLE2	1.61e-04	163	92	5	DOID:1826 (implicated_via_orthology)
Disease	Graves' disease (is_implicated_in)	ADRB2 LTA DNMT1	2.47e-04	39	92	3	DOID:12361 (is_implicated_in)
Disease	aflatoxin B1 aldehyde reductase member 2 measurement	AKR7A2 AKR7A3	2.66e-04	8	92	2	EFO_0020132
Disease	executive function measurement, unipolar depression, cognitive function measurement	PDE3A ADAMTS5 PTAR1	5.48e-04	51	92	3	EFO_0003761, EFO_0008354, EFO_0009332
Disease	neutrophil count, eosinophil count	ADRB2 PMPCA PTPRJ KIT DNMT1	5.53e-04	213	92	5	EFO_0004833, EFO_0004842
Disease	Hepatomegaly	CYP1B1 ADAMTS5 AKR7A3	6.48e-04	54	92	3	C0019209
Disease	neutrophil count, basophil count	ADRB2 PMPCA PTPRJ KIT DNMT1	6.94e-04	224	92	5	EFO_0004833, EFO_0005090
Disease	peak expiratory flow	CYP1B1 PDE3A GRID1 ADAMTS5 ADRB2 PRICKLE3 PDZRN3	9.53e-04	498	92	7	EFO_0009718
Disease	unipolar depression, cognitive function measurement	ADAMTS5 PTAR1	9.83e-04	15	92	2	EFO_0003761, EFO_0008354
Disease	myocardial infarction (implicated_via_orthology)	CYP1B1 CS PDE5A	1.16e-03	66	92	3	DOID:5844 (implicated_via_orthology)
Disease	granulocyte count	ADRB2 PMPCA PTPRJ KIT DNMT1	1.22e-03	254	92	5	EFO_0007987
Disease	response to cyclophosphamide	HIPK2 TRIM9	1.27e-03	17	92	2	GO_1902518
Disease	spinal stenosis	PDE3A AGMO	1.27e-03	17	92	2	EFO_0007490
Disease	oleoylcarnitine measurement	AKR7A2 AKR7A3	1.59e-03	19	92	2	EFO_0021043
Disease	nicotine dependence symptom count, depressive symptom measurement	ADRB2 AGMO NLE1	1.68e-03	75	92	3	EFO_0007006, EFO_0009262
Disease	pancreatic carcinoma	GRID1 ASB3 KIT TARS1	2.18e-03	174	92	4	EFO_0002618
Disease	primary open angle glaucoma (is_implicated_in)	CYP1B1 ADRB2	2.33e-03	23	92	2	DOID:1070 (is_implicated_in)
Disease	body fat percentage, coronary artery disease	DYNC2H1 DGKH	2.54e-03	24	92	2	EFO_0001645, EFO_0007800
Disease	lung squamous cell carcinoma (is_implicated_in)	CYP1B1 PTPRJ	2.54e-03	24	92	2	DOID:3907 (is_implicated_in)
Disease	interstitial lung disease (is_marker_for)	TLR9 KIT	2.75e-03	25	92	2	DOID:3082 (is_marker_for)
Disease	anogenital venereal wart (is_marker_for)	TLR9 KLRK1	2.98e-03	26	92	2	DOID:11168 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALSVSNMSHHWAGEY	ADGRF3	296	Q8IZF5
MHWYRATHQEAINCY	ADRB2	171	P07550
LRWMYHHSQLQGAHG	AKR7A2	296	O43488
WHVHTCGLANMFAYH	AIPL1	116	Q9NZN9
HGNEMSGVYLARHWL	ACY3	21	Q96HD9
AALRWMYHHSQLQGA	AKR7L	266	Q8NHP1
ATLRWMYHHSQLQGA	AKR7A3	266	O95154
AYSFPQQHTMQHWAR	CACNA2D2	61	Q9NY47
ALWEDSSNGQMFHAH	DNMT1	781	P26358
MWAGHQTHHSSEDYN	AGMO	141	Q6ZNB7
MNYSGWSHRDDFLHG	ADAMTS5	806	Q9UNA0
WSHRDDFLHGMGYSA	ADAMTS5	811	Q9UNA0
NWHGVHKNDDRSSYA	ECT2L	271	Q008S8
MDYSLAAALTLHGHW	SDHD	91	O14521
GYSHWYSSPHQDTMQ	DLX6	156	P56179
SLTSLVDYWHFNMHD	CFAP44	841	Q96MT7
RESWMLHNSGFRNYN	PDZRN3	716	Q9UPQ7
HFYLGSANMDWRSLT	PLD3	211	Q8IV08
GMHCWYSSYSHRTQH	DGKK	326	Q5KSL6
GLAWSSHDAESFQMH	PTPRJ	471	Q12913
YNQSEAGSHTLQWMH	HLA-E	106	P13747
DHWMQYRLSGSFAHQ	LIM2	26	P55344
WRNTHAHGSHYNPIM	HIPK2	751	Q9H2X6
GFTFSSYAMHWVRQA	IGHV3-64	46	A0A075B6Q5
EHYNSHRGLIMYSWD	CD58	146	P19256
DWNGDHIHTNFRDMY	MBTPS1	651	Q14703
SWHHGDFNYERQATL	KIT	261	P10721
CNNRHFWMFHSQAVY	FAM72D	96	Q6L9T8
TGLMQLTWLYLDHNH	LRRTM1	86	Q86UE6
YHVSGEFAMLWHGAQ	ALAD	276	P13716
YSLHGFIMHNNDLTW	ASMTL	371	O95671
WMQLGAFYPFSRNHN	MGAM	1571	O43451
MEEYHTWQNFGNSHR	HECTD2	351	Q5U5R9
MAHHSLNTFYIWHNN	LINC00312	1	Q9Y6C7
TNSGYSGMWHRAEHA	EXTL2	276	Q9UBQ6
AYHRWNGHTDMIDQD	PCYOX1	481	Q9UHG3
HNWMHAFSVSHFCYL	PDE2A	656	O00408
ENHHAAAAWNLFMSR	PDE3A	866	Q14432
AYHNWRHAFNTAQCM	PDE5A	611	O76074
YHNWRHGFNVAQTMF	PDE6B	556	P35913
YHNWRHGFNVGQTMF	PDE6C	561	P51160
HSWEMSEFHNYNLDL	KLRK1	11	P26718
CNNGHFWMFHSQAVY	FAM72A	96	Q5TYM5
MTGSHLSHDSWQYVL	OVOS2	1	Q6IE36
QFNVEHFSGMHNWYA	DGKH	166	Q86XP1
HFSGMHNWYACSHAR	DGKH	171	Q86XP1
INHMVNHSWGRQYSH	HCN3	286	Q9P1Z3
MAAAEHRHSSGLPYW	NPIPA2	236	E9PIF3
GRFDYWGNSHQIMHL	PAQR4	231	Q8N4S7
DHAQMTYDGQHWHAT	PRICKLE1	261	Q96MT3
QGQMTYDGQHWHATE	PRICKLE2	266	Q7Z3G6
DQGQMAYEGQHWHAS	PRICKLE3	321	O43900
SSGMEFQDHRYWLRT	PIKFYVE	366	Q9Y2I7
IEAHGSYFHMAAWGL	FZD9	351	O00144
DNMSDSFYVTWGARH	DYNC2H1	2566	Q8NCM8
NRGWMPIHEAAYHNS	ASB3	41	Q9Y575
GQSHAAVLWMEYHLT	PRMT7	606	Q9NVM4
QDFTWSQHYSGGHTM	FABP6	46	P51161
HYMPDHWQGNAHRSQ	ATG9A	446	Q7Z3C6
WSHNFTNMLGYTDHQ	CS	236	O75390
CNNRHFWMFHSQAVY	FAM72C	96	H0Y354
HAWMNYTAILFTHAE	GIMD1	136	P0DJR0
SRNHYGWSALMQAAR	ANKS6	106	Q68DC2
DSVHGWTALMQATYH	ANKS6	356	Q68DC2
HFAATHSLEFMWRQT	MAN2A2	321	P49641
HTAESYMLQWQRGHL	NSMAF	296	Q92636
RYGHQLHNTSWNGMI	GRID1	491	Q9ULK0
SMAFGHYSEHWKVQR	CYP1B1	131	Q16678
NEHLHMFTIWLGYIN	HRH1	446	P35367
QWHVAEGLSMDSHLY	GRIK4	391	Q16099
WHMAYHGSNVAAVRR	NEURL4	1416	Q96JN8
CNNGHFWMFHSQAVY	FAM72B	96	Q86X60
FRAMWKLFSSHYNVH	PPEF1	591	O14829
EGIWSYLMHFLFDHS	OR52I1	306	Q8NGK6
EYWQSLEVSHHMVFN	PIGB	86	Q92521
GHWQHYSENMFTFEI	TARS3	466	A2RTX5
SGHWQHYSENMFSFE	TARS1	386	P26639
HGHWVNTMALSTDYA	NLE1	286	Q9NVX2
NVLNRHHWMYNATSY	PMPCA	366	Q10713
LGAVEFHYFQRMSSW	TRMT13	356	Q9NUP7
WASMHVSDHSGFHYR	PTAR1	226	Q7Z6K3
SMGTNYHFHSWRVFV	SV2B	266	Q7L1I2
MTGINYLDTHSNFWR	ODAD4	226	Q96NG3
WVHDAYSQAHLTLMA	FTSJ3	126	Q8IY81
FIYESWLIHHGTQMS	DIP2C-AS1	71	Q8N8Z3
YSVHNGNFQTWMGAH	IL9R	316	Q01113
SFQMGSAYQFHSWRV	SV2A	321	Q7L0J3
ENHYHTFLLWAMRGI	URGCP	221	Q8TCY9
EPWLHSMYHGAAFQL	LTA	161	P01374
QMRWFLRETGHYHSF	TLCD5	141	Q6ZRR5
YVDNNRSWFMHCNSH	TRIM67	691	Q6ZTA4
FRTNFRLWSHFQSHM	ZBTB21	946	Q9ULJ3
HAGLYMWHLVGHQRN	SECTM1	111	Q8WVN6
GHMWAEGDLYLHFFQ	TLR9	611	Q9NR96
YHSSQWMVAGNTDHL	TBX22	156	Q9Y458
WFMHNNSHTNRTEGG	TRIM9	626	Q9C026
RHDAAEITVMHYWFG	PIGG	836	Q5H8A4
DFHQSMAQWLAYSRL	UNC13D	346	Q70J99
DWVHGRISNFHYLMQ	WDR81	351	Q562E7
AAAHWYGGAEMRTQH	MYORG	181	Q6NSJ0