Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	SETD1A KMT2D SETD1B KMT2B	2.84e-09	8	52	4	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	SETD1A KMT2D SETD1B KMT2B	8.49e-09	10	52	4	GO:0140999
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	1.92e-07	20	52	4	GO:0042800
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	5.14e-06	44	52	4	GO:0140938
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	2.94e-05	68	52	4	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	3.12e-05	69	52	4	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	3.49e-05	71	52	4	GO:0042054
GeneOntologyMolecularFunction	protein methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	1.49e-04	103	52	4	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	1.61e-04	105	52	4	GO:0008170
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	1.04e-03	172	52	4	GO:0008757
GeneOntologyMolecularFunction	methyltransferase activity	SETD1A KMT2D SETD1B KMT2B	2.28e-03	213	52	4	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	SETD1A KMT2D SETD1B KMT2B	2.74e-03	224	52	4	GO:0016741
GeneOntologyMolecularFunction	histone modifying activity	SETD1A KMT2D SETD1B KMT2B	2.96e-03	229	52	4	GO:0140993
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 MCOLN1	3.34e-03	33	52	2	GO:0005217
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	CARMIL2 MAVS LRRC24 ARHGEF5 KATNB1 COBL ZNF205 TNKS ICE1 PLD2 HSF1 TESK1 MCOLN1	1.98e-05	1366	51	13	GO:0051130
GeneOntologyBiologicalProcess	positive regulation of organelle organization	CARMIL2 ARHGEF5 KATNB1 ZNF205 TNKS HSF1 TESK1 MCOLN1	7.60e-05	574	51	8	GO:0010638
GeneOntologyBiologicalProcess	positive regulation of cellular component biogenesis	CARMIL2 MAVS LRRC24 ARHGEF5 COBL ICE1 HSF1 TESK1	8.37e-05	582	51	8	GO:0044089
GeneOntologyCellularComponent	histone methyltransferase complex	SETD1A KMT2D SETD1B KMT2B	3.11e-05	75	50	4	GO:0035097
GeneOntologyCellularComponent	methyltransferase complex	SETD1A KMT2D SETD1B KMT2B	1.29e-04	108	50	4	GO:0034708
GeneOntologyCellularComponent	Set1C/COMPASS complex	SETD1A SETD1B	6.59e-04	16	50	2	GO:0048188
GeneOntologyCellularComponent	euchromatin	SETD1A ICE1 HSF1	6.84e-04	72	50	3	GO:0000791
GeneOntologyCellularComponent	nuclear body	SETD1A NCOR2 SETD1B TNKS ICE1 RERE HSF1 SF1	1.26e-03	903	50	8	GO:0016604
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	GRID2IP NLGN4X	1.50e-03	24	50	2	GO:0098985
Domain	Post-SET_dom	SETD1A KMT2D SETD1B KMT2B	7.43e-08	16	49	4	IPR003616
Domain	PostSET	SETD1A KMT2D SETD1B KMT2B	7.43e-08	16	49	4	SM00508
Domain	POST_SET	SETD1A KMT2D SETD1B KMT2B	7.43e-08	16	49	4	PS50868
Domain	SET	SETD1A KMT2D SETD1B KMT2B	3.94e-06	41	49	4	PF00856
Domain	SET	SETD1A KMT2D SETD1B KMT2B	6.29e-06	46	49	4	SM00317
Domain	N-SET	SETD1A SETD1B	6.74e-06	2	49	2	PF11764
Domain	COMPASS_Set1_N-SET	SETD1A SETD1B	6.74e-06	2	49	2	IPR024657
Domain	N-SET	SETD1A SETD1B	6.74e-06	2	49	2	SM01291
Domain	SET_dom	SETD1A KMT2D SETD1B KMT2B	8.81e-06	50	49	4	IPR001214
Domain	SET	SETD1A KMT2D SETD1B KMT2B	8.81e-06	50	49	4	PS50280
Domain	PH_dom-like	ARHGEF5 PLEKHA4 PLD2 ARHGAP27 ARHGEF17 WDFY4 MAPK8IP2 PLEKHH3	1.36e-05	426	49	8	IPR011993
Domain	FYrich_C	KMT2D KMT2B	6.71e-05	5	49	2	IPR003889
Domain	FYrich_N	KMT2D KMT2B	6.71e-05	5	49	2	IPR003888
Domain	FYRC	KMT2D KMT2B	6.71e-05	5	49	2	SM00542
Domain	FYRN	KMT2D KMT2B	6.71e-05	5	49	2	SM00541
Domain	FYRN	KMT2D KMT2B	6.71e-05	5	49	2	PF05964
Domain	FYRC	KMT2D KMT2B	6.71e-05	5	49	2	PF05965
Domain	FYRC	KMT2D KMT2B	6.71e-05	5	49	2	PS51543
Domain	FYRN	KMT2D KMT2B	6.71e-05	5	49	2	PS51542
Domain	-	ARHGEF5 PLEKHA4 PLD2 ARHGAP27 ARHGEF17 MAPK8IP2 PLEKHH3	6.72e-05	391	49	7	2.30.29.30
Domain	PH	ARHGEF5 PLEKHA4 PLD2 ARHGAP27 PLEKHH3	7.87e-04	278	49	5	SM00233
Domain	PH_DOMAIN	ARHGEF5 PLEKHA4 PLD2 ARHGAP27 PLEKHH3	8.00e-04	279	49	5	PS50003
Domain	PH_domain	ARHGEF5 PLEKHA4 PLD2 ARHGAP27 PLEKHH3	8.13e-04	280	49	5	IPR001849
Domain	EPHD	KMT2D KMT2B	1.51e-03	22	49	2	PS51805
Domain	SANT_dom	NCOR2 RERE	2.11e-03	26	49	2	IPR017884
Domain	SANT	NCOR2 RERE	2.44e-03	28	49	2	PS51293
Domain	PH	ARHGEF5 PLEKHA4 PLD2 ARHGAP27	3.03e-03	229	49	4	PF00169
Domain	CNMP_BINDING_1	PNPLA6 HCN4	3.18e-03	32	49	2	PS00888
Domain	CNMP_BINDING_2	PNPLA6 HCN4	3.18e-03	32	49	2	PS00889
Domain	cNMP	PNPLA6 HCN4	3.59e-03	34	49	2	SM00100
Domain	cNMP_binding	PNPLA6 HCN4	3.59e-03	34	49	2	PF00027
Domain	cNMP-bd_dom	PNPLA6 HCN4	3.80e-03	35	49	2	IPR000595
Domain	CNMP_BINDING_3	PNPLA6 HCN4	3.80e-03	35	49	2	PS50042
Domain	Myb_DNA-binding	NCOR2 RERE	3.80e-03	35	49	2	PF00249
Domain	MYB_LIKE	NCOR2 RERE	4.46e-03	38	49	2	PS50090
Domain	cNMP-bd-like	PNPLA6 HCN4	4.46e-03	38	49	2	IPR018490
Domain	-	PNPLA6 HCN4	7.04e-03	48	49	2	2.60.120.10
Domain	SANT	NCOR2 RERE	7.62e-03	50	49	2	SM00717
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	SETD1A KMT2D SETD1B KMT2B	2.21e-06	38	35	4	MM17073
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	SETD1A KMT2D SETD1B KMT2B	3.33e-06	42	35	4	M48018
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	SETD1A KMT2D SETD1B KMT2B	4.03e-06	44	35	4	MM15527
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	SETD1A KMT2D SETD1B KMT2B	4.82e-06	46	35	4	MM14933
Pathway	WP_HISTONE_MODIFICATIONS	SETD1A KMT2D SETD1B KMT2B	1.94e-05	65	35	4	M39374
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	SETD1A KMT2D SETD1B KMT2B	2.60e-05	70	35	4	M27231
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	SETD1A NCOR2 KMT2D SETD1B KMT2B	6.68e-05	175	35	5	MM14941
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	SETD1A KMT2D SETD1B KMT2B	8.99e-05	96	35	4	M27792
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	SETD1A KMT2D SETD1B KMT2B	3.44e-04	136	35	4	MM14848
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	SETD1A NCOR2 KMT2D SETD1B KMT2B	5.21e-04	272	35	5	M29619
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	SETD1A KMT2D SETD1B KMT2B	5.38e-04	153	35	4	MM15522
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1A KMT2D SETD1B KMT2B	4.20e-10	8	56	4	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	SETD1A KMT2D SETD1B KMT2B	4.20e-10	8	56	4	22266653
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	SETD1A KMT2D SETD1B KMT2B	7.55e-10	9	56	4	22665483
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A NCOR2 KMT2D SETD1B PNPLA6 KMT2B LRRC24 SIPA1L3 COBL ICE1 ALKBH6 TESK1 CIC PLEKHH3	1.65e-09	1105	56	14	35748872
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	SETD1A KMT2D SETD1B KMT2B	2.95e-09	12	56	4	27563068
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	SETD1A KMT2D SETD1B KMT2B	1.08e-08	16	56	4	24368734
Pubmed	Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.	SETD1A SETD1B KMT2B	3.94e-08	5	56	3	25561738
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	SETD1A KMT2D SETD1B KMT2B	4.31e-08	22	56	4	26886794
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	SETD1A KMT2D SETD1B KMT2B	1.84e-07	31	56	4	20516061
Pubmed	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.	SETD1A SETD1B KMT2B	4.71e-07	10	56	3	18838538
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	SETD1A KMT2D KMT2B RERE	7.10e-07	43	56	4	33472061
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	SETD1A KMT2D SETD1B KMT2B	1.31e-06	50	56	4	37974198
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	SETD1A KMT2D SETD1B KMT2B ARHGEF17	1.43e-06	119	56	5	23508102
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	SETD1A SETD1B KMT2B	2.18e-06	16	56	3	23870121
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETD1A KMT2D SETD1B KMT2B	2.23e-06	57	56	4	18022353
Pubmed	Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.	KMT2D KMT2B	2.55e-06	2	56	2	35506254
Pubmed	In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F).	SETD1A SETD1B	2.55e-06	2	56	2	38003223
Pubmed	Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).	KMT2D KMT2B	2.55e-06	2	56	2	35640156
Pubmed	The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.	SETD1A SETD1B	2.55e-06	2	56	2	24550110
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	SETD1A KMT2D KMT2B	3.17e-06	18	56	3	17500065
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOR2 KMT2D PNPLA6 KMT2B RERE HSF1 SF1 CIC MEF2D	3.80e-06	774	56	9	15302935
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	SETD1A KMT2D SETD1B	4.42e-06	20	56	3	29785026
Pubmed	WDR82, a key epigenetics-related factor, plays a crucial role in normal early embryonic development in mice.	SETD1A SETD1B	7.63e-06	3	56	2	21123813
Pubmed	Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.	KMT2D KMT2B	7.63e-06	3	56	2	32544095
Pubmed	Cloning and characterization of the mouse Mcoln1 gene reveals an alternatively spliced transcript not seen in humans.	PNPLA6 MCOLN1	7.63e-06	3	56	2	11897010
Pubmed	Molecular insight into the SETD1A/B N-terminal region and its interaction with WDR82.	SETD1A SETD1B	7.63e-06	3	56	2	37030068
Pubmed	Chromosomal mapping of the tankyrase gene in human and mouse.	ADRB3 TNKS	7.63e-06	3	56	2	10198177
Pubmed	The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.	KMT2D KMT2B	7.63e-06	3	56	2	23358417
Pubmed	The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.	SETD1A SETD1B	7.63e-06	3	56	2	33567280
Pubmed	The DNA sequence and analysis of human chromosome 13.	PRR20C PRR20D PRR20B PRR20E PRR20A	8.21e-06	170	56	5	15057823
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FAM117A CARMIL2 ARHGEF5 SIPA1L3 COBL ARHGEF17 TESK1 CIC MEF2D	8.95e-06	861	56	9	36931259
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2D KMT2B	1.52e-05	4	56	2	19221051
Pubmed	MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.	KMT2D KMT2B	1.52e-05	4	56	2	20808952
Pubmed	Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.	KMT2D KMT2B	1.52e-05	4	56	2	23826075
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2D KMT2B	1.52e-05	4	56	2	23129768
Pubmed	Interaction network of human early embryonic transcription factors.	SETD1A NCOR2 KMT2D KMT2B RERE UBN2	2.15e-05	351	56	6	38297188
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETD1A KMT2B ARHGEF17 CIC	2.46e-05	104	56	4	9205841
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2D KMT2B	2.54e-05	5	56	2	26320581
Pubmed	p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation.	KMT2D MEF2D	2.54e-05	5	56	2	18026121
Pubmed	Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex.	NCOR2 SF1	2.54e-05	5	56	2	16002533
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2D KMT2B	2.54e-05	5	56	2	28609655
Pubmed	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.	SETD1A KMT2D	3.80e-05	6	56	2	34933446
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2D KMT2B	3.80e-05	6	56	2	16199523
Pubmed	Sex reversal following deletion of a single distal enhancer of Sox9.	AMH SF1	3.80e-05	6	56	2	29903884
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2D KMT2B	3.80e-05	6	56	2	24176642
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2D KMT2B	3.80e-05	6	56	2	17021013
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	FAM117A SIPA1L3 ICE1 ARHGEF17	4.60e-05	122	56	4	30773093
Pubmed	Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.	NCOR2 RERE	5.32e-05	7	56	2	16481466
Pubmed	Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.	KMT2D KMT2B	5.32e-05	7	56	2	23995757
Pubmed	CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation.	SETD1A SETD1B	5.32e-05	7	56	2	19433449
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2D KMT2B	5.32e-05	7	56	2	30604749
Pubmed	Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.	KMT2D KMT2B	5.32e-05	7	56	2	16540515
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2D KMT2B	5.32e-05	7	56	2	19556342
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NCOR2 KMT2D KMT2B ICE1 RERE CIC	5.68e-05	418	56	6	34709266
Pubmed	CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.	SETD1A SETD1B	7.09e-05	8	56	2	18680430
Pubmed	Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2.	NCOR2 MEF2D	7.09e-05	8	56	2	17158926
Pubmed	Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.	SETD1A SETD1B	7.09e-05	8	56	2	17355966
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	KMT2D RERE UBN2 CIC MEF2D	7.25e-05	268	56	5	33640491
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NCOR2 MAVS HSF1 UBN2 SF1 MEF2D	7.92e-05	444	56	6	34795231
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	KMT2D KMT2B	9.10e-05	9	56	2	16951254
Pubmed	Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.	SETD1A KMT2D	9.10e-05	9	56	2	26691508
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOR2 UBN2 SF1 CIC	1.08e-04	152	56	4	38360978
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	SETD1A SETD1B	1.14e-04	10	56	2	17998332
Pubmed	FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.	KMT2B SF1	1.14e-04	10	56	2	9171351
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	SETD1A SETD1B KMT2B	1.33e-04	61	56	3	20305087
Pubmed	Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.	SETD1A KMT2D	1.39e-04	11	56	2	18082152
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	PWWP2A SETD1A KMT2D SETD1B KMT2B RERE	1.43e-04	495	56	6	27705803
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOR2 LRRC24 HCN4 SIPA1L3 TNKS BRSK1 UBN2 MAPK8IP2	1.47e-04	963	56	8	28671696
Pubmed	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.	KMT2D KMT2B	1.66e-04	12	56	2	17707229
Pubmed	Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents.	AMH SF1	1.66e-04	12	56	2	23071697
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	SETD1A KMT2D SETD1B	1.92e-04	69	56	3	28481362
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	SETD1A KMT2B	1.96e-04	13	56	2	24619213
Pubmed	Germ cells are not required to establish the female pathway in mouse fetal gonads.	AMH SF1	1.96e-04	13	56	2	23091613
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2D KMT2B	1.96e-04	13	56	2	21502505
Pubmed	Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.	ARHGEF5 RERE ARHGAP27	2.18e-04	72	56	3	12107413
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	NCOR2 KMT2D SIPA1L3 MEF2D	2.25e-04	184	56	4	32908313
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	UBN2 CIC	2.29e-04	14	56	2	28263302
Pubmed	Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.	MAVS TNKS	2.29e-04	14	56	2	35733260
Pubmed	ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.	AMH SF1	2.64e-04	15	56	2	29735715
Pubmed	Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.	KMT2D KMT2B	3.01e-04	16	56	2	24788516
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOR2 KMT2D CIC	3.32e-04	83	56	3	28794006
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2D KMT2B	3.41e-04	17	56	2	26180087
Pubmed	Chromosomal mapping of Adam9, Adam15 and Adam21.	ADRB3 TNKS	3.83e-04	18	56	2	10842103
Pubmed	Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.	AMH SF1	4.28e-04	19	56	2	30212841
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2D KMT2B	4.75e-04	20	56	2	19047629
Pubmed	FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.	NCOR2 SETD1B	4.75e-04	20	56	2	27773593
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2D KMT2B	5.24e-04	21	56	2	27626377
Pubmed	Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.	AMH SF1	5.24e-04	21	56	2	23300469
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	ARHGEF5 SIPA1L3 ARHGEF17	6.06e-04	102	56	3	15778465
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	NCOR2 KMT2D	6.30e-04	23	56	2	9225980
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SETD1A NCOR2 ARHGEF5 TNKS CIC	6.42e-04	430	56	5	35044719
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1A KMT2D SETD1B KMT2B	7.25e-04	251	56	4	31076518
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	NCOR2 KMT2D PNPLA6 CIC MEF2D	8.44e-04	457	56	5	32344865
Pubmed	Retinoic Acid Antagonizes Testis Development in Mice.	AMH SF1	8.71e-04	27	56	2	30067986
Pubmed	Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.	AMH SF1	9.37e-04	28	56	2	25668066
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PWWP2A NCOR2 KMT2D KMT2B ZNF205 UBN2 SF1 CIC	1.04e-03	1294	56	8	30804502
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PWWP2A SIPA1L3 CC2D1B UBN2 WDFY4	1.18e-03	493	56	5	15368895
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SETD1A KMT2B SF1	1.34e-03	134	56	3	25452129
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	KMT2D MAVS ARHGEF5	1.48e-03	139	56	3	25476789
Interaction	ZNF683 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.44e-11	10	56	5	int:ZNF683
Interaction	CELF4 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.29e-11	11	56	5	int:CELF4
Interaction	BEND2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.08e-10	12	56	5	int:BEND2
Interaction	PTTG2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.71e-10	14	56	5	int:PTTG2
Interaction	MBNL3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.89e-10	16	56	5	int:MBNL3
Interaction	PITX1 interactions	PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A SF1 CIC	2.19e-09	127	56	8	int:PITX1
Interaction	PRR34 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.71e-09	21	56	5	int:PRR34
Interaction	TPRX1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.71e-09	21	56	5	int:TPRX1
Interaction	C3orf36 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	8.68e-09	26	56	5	int:C3orf36
Interaction	SMAP1 interactions	PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A	3.06e-08	67	56	6	int:SMAP1
Interaction	ZNF385C interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.09e-08	33	56	5	int:ZNF385C
Interaction	HLX interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.62e-08	37	56	5	int:HLX
Interaction	ZCCHC14 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.62e-08	37	56	5	int:ZCCHC14
Interaction	VAC14 interactions	NUDT19 PRR20C PRR20D PRR20B MAVS PRR20E PLEKHA4 PRR20A	8.03e-08	201	56	8	int:VAC14
Interaction	TBX6 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	9.58e-08	41	56	5	int:TBX6
Interaction	TLX3 interactions	NCOR2 PRR20C PRR20D KMT2D PRR20B PRR20E PRR20A RERE CIC	1.01e-07	291	56	9	int:TLX3
Interaction	FAM222B interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.09e-07	42	56	5	int:FAM222B
Interaction	SAMD11 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.23e-07	43	56	5	int:SAMD11
Interaction	BICRAL interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.23e-07	43	56	5	int:BICRAL
Interaction	NCOA6 interactions	SETD1A NCOR2 KMT2D SETD1B KMT2B HSF1 SF1	1.49e-07	145	56	7	int:NCOA6
Interaction	SP4 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.73e-07	46	56	5	int:SP4
Interaction	KRTAP19-1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.94e-07	47	56	5	int:KRTAP19-1
Interaction	BUB3 interactions	SETD1A KMT2D SETD1B KMT2B PLEKHA4 RERE HSF1 CIC	2.41e-07	232	56	8	int:BUB3
Interaction	OXER1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.66e-07	50	56	5	int:OXER1
Interaction	RIPPLY1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	4.32e-07	55	56	5	int:RIPPLY1
Interaction	ZBTB32 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.65e-07	58	56	5	int:ZBTB32
Interaction	NFYC interactions	SETD1A PRR20C PRR20D PRR20B PRR20E PRR20A CIC	5.78e-07	177	56	7	int:NFYC
Interaction	FAM9A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.16e-07	59	56	5	int:FAM9A
Interaction	CABP2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	7.29e-07	61	56	5	int:CABP2
Interaction	C10orf55 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.00e-06	65	56	5	int:C10orf55
Interaction	HYPK interactions	PRR20C PRR20D PRR20B PRR20E PRR20A HSF1	1.27e-06	125	56	6	int:HYPK
Interaction	TBX3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.35e-06	69	56	5	int:TBX3
Interaction	TOP3B interactions	NUDT19 SETD1A NCOR2 KMT2D SETD1B PNPLA6 KMT2B LRRC24 SIPA1L3 PLEKHA4 COBL ICE1 ALKBH6 TESK1 CIC PLEKHH3	1.50e-06	1470	56	16	int:TOP3B
Interaction	CCNK interactions	SETD1A PRR20C PRR20D PRR20B PRR20E PRR20A	1.75e-06	132	56	6	int:CCNK
Interaction	SETD1B interactions	SETD1A KMT2D SETD1B KMT2B RERE	2.05e-06	75	56	5	int:SETD1B
Interaction	ESRP1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.34e-06	77	56	5	int:ESRP1
Interaction	VPS37C interactions	PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A	2.57e-06	141	56	6	int:VPS37C
Interaction	FAM168A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A SF1	2.67e-06	142	56	6	int:FAM168A
Interaction	KLF3 interactions	SETD1A NCOR2 KMT2D KMT2B UBN2 CIC MEF2D	3.13e-06	228	56	7	int:KLF3
Interaction	PRR35 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.40e-06	83	56	5	int:PRR35
Interaction	RBPMS2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.40e-06	83	56	5	int:RBPMS2
Interaction	POU6F2 interactions	VPS9D1 PRR20C PRR20D PRR20B PRR20E PRR20A	3.40e-06	148	56	6	int:POU6F2
Interaction	DMRT3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	4.29e-06	87	56	5	int:DMRT3
Interaction	H3C14 interactions	SETD1A KMT2D SETD1B KMT2B PLEKHA4 RERE	4.61e-06	156	56	6	int:H3C14
Interaction	PRR20B interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.07e-06	90	56	5	int:PRR20B
Interaction	PRR20C interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.07e-06	90	56	5	int:PRR20C
Interaction	PRR20D interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.07e-06	90	56	5	int:PRR20D
Interaction	LASP1 interactions	NCOR2 PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A	5.31e-06	247	56	7	int:LASP1
Interaction	HCFC2 interactions	SETD1A KMT2D SETD1B KMT2B RERE	5.65e-06	92	56	5	int:HCFC2
Interaction	KDM6A interactions	SETD1A KMT2D SETD1B KMT2B PLEKHA4 RERE	5.73e-06	162	56	6	int:KDM6A
Interaction	RBM23 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.28e-06	94	56	5	int:RBM23
Interaction	SETD1A interactions	SETD1A KMT2D SETD1B KMT2B PLEKHA4 RERE	7.55e-06	170	56	6	int:SETD1A
Interaction	TIAL1 interactions	PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A	8.07e-06	172	56	6	int:TIAL1
Interaction	PHF1 interactions	PWWP2A PRR20C PRR20D PRR20B PRR20E PRR20A	8.07e-06	172	56	6	int:PHF1
Interaction	KRTAP19-5 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	8.09e-06	99	56	5	int:KRTAP19-5
Interaction	ASH2L interactions	SETD1A KMT2D SETD1B KMT2B ICE1 RERE MEF2D	8.40e-06	265	56	7	int:ASH2L
Interaction	POGZ interactions	PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A CIC	8.40e-06	265	56	7	int:POGZ
Interaction	POU2F1 interactions	NCOR2 PRR20C PRR20D PRR20B PRR20E PRR20A	8.91e-06	175	56	6	int:POU2F1
Interaction	PRR20E interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	8.92e-06	101	56	5	int:PRR20E
Interaction	TRIM35 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	9.82e-06	103	56	5	int:TRIM35
Interaction	C1orf94 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	9.82e-06	103	56	5	int:C1orf94
Interaction	GTF2A1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.03e-05	104	56	5	int:GTF2A1
Interaction	RHOXF2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.03e-05	104	56	5	int:RHOXF2
Interaction	VENTX interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.03e-05	104	56	5	int:VENTX
Interaction	VEZF1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.08e-05	105	56	5	int:VEZF1
Interaction	GLIS2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.13e-05	106	56	5	int:GLIS2
Interaction	SH3RF1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.24e-05	108	56	5	int:SH3RF1
Interaction	FOXH1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.29e-05	109	56	5	int:FOXH1
Interaction	PRR20A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.29e-05	109	56	5	int:PRR20A
Interaction	RBBP5 interactions	SETD1A KMT2D SETD1B KMT2B PLEKHA4 RERE MEF2D	1.41e-05	287	56	7	int:RBBP5
Interaction	PHF20 interactions	SETD1A SETD1B KMT2B RERE	1.41e-05	53	56	4	int:PHF20
Interaction	NOTCH3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.54e-05	113	56	5	int:NOTCH3
Interaction	HCFC1 interactions	SETD1A KMT2D SETD1B KMT2B PLEKHA4 RERE CIC	1.61e-05	293	56	7	int:HCFC1
Interaction	BHLHE40 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.98e-05	119	56	5	int:BHLHE40
Interaction	THAP1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.98e-05	119	56	5	int:THAP1
Interaction	FEV interactions	SETD1A NCOR2 KMT2D KMT2B UBN2 CIC	2.07e-05	203	56	6	int:FEV
Interaction	DPY30 interactions	PWWP2A SETD1A KMT2D SETD1B KMT2B RERE	2.13e-05	204	56	6	int:DPY30
Interaction	WDR82 interactions	SETD1A KMT2D SETD1B KMT2B MAVS PLEKHA4	2.72e-05	213	56	6	int:WDR82
Interaction	KMT2B interactions	SETD1A KMT2D SETD1B KMT2B RERE	3.03e-05	130	56	5	int:KMT2B
Interaction	CXXC1 interactions	SETD1A KMT2D SETD1B KMT2B RERE	3.26e-05	132	56	5	int:CXXC1
Interaction	KLF8 interactions	SETD1A NCOR2 KMT2D KMT2B UBN2 CIC MEF2D	3.38e-05	329	56	7	int:KLF8
Interaction	YPEL3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.38e-05	133	56	5	int:YPEL3
Interaction	KANSL2 interactions	SETD1A SETD1B KMT2B RERE	4.28e-05	70	56	4	int:KANSL2
Interaction	BAG2 interactions	SETD1A MAVS PLEKHA4 PLD2 HSF1 UBN2 SF1 CIC MEF2D	4.97e-05	622	56	9	int:BAG2
Interaction	NUP43 interactions	SETD1A NCOR2 KMT2D SETD1B KMT2B MAVS ICE1 RERE UBN2	5.16e-05	625	56	9	int:NUP43
Interaction	ARID5A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.46e-05	147	56	5	int:ARID5A
Interaction	PHF20L1 interactions	SETD1A SETD1B KMT2B RERE	5.61e-05	75	56	4	int:PHF20L1
Interaction	PAXIP1 interactions	SETD1A KMT2D SETD1B CARMIL2 KMT2B PLEKHA4 CIC	5.88e-05	359	56	7	int:PAXIP1
Interaction	CHAF1B interactions	PWWP2A NCOR2 PLEKHA4 HSF1 CIC	7.69e-05	158	56	5	int:CHAF1B
Interaction	TFG interactions	PRR20C PRR20D PRR20B PRR20E PLEKHA4 PRR20A	7.89e-05	258	56	6	int:TFG
Interaction	NCK2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A SF1	8.59e-05	262	56	6	int:NCK2
Interaction	PATZ1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	8.91e-05	163	56	5	int:PATZ1
Interaction	IRF4 interactions	NCOR2 KMT2D CIC MEF2D	9.16e-05	85	56	4	int:IRF4
Interaction	KANSL3 interactions	SETD1A SETD1B KMT2B RERE	9.58e-05	86	56	4	int:KANSL3
Interaction	SAP30 interactions	PWWP2A NCOR2 SETD1B PLEKHA4 CIC	9.99e-05	167	56	5	int:SAP30
Interaction	ASRGL1 interactions	PLEKHA4 PLD2 MAPK8IP2	1.05e-04	33	56	3	int:ASRGL1
Interaction	MEN1 interactions	SETD1A KMT2D SETD1B PNPLA6 KMT2B PLEKHA4 COBL RERE ARHGEF17 SF1 MEF2D	1.05e-04	1029	56	11	int:MEN1
Interaction	YEATS2 interactions	SETD1A SETD1B KMT2B PLEKHA4 RERE	1.06e-04	169	56	5	int:YEATS2
Interaction	KMT2D interactions	SETD1A KMT2D SETD1B KMT2B MEF2D	1.06e-04	169	56	5	int:KMT2D
Interaction	HNF4A interactions	SETD1A NCOR2 KMT2D KMT2B UBN2 CIC	1.12e-04	275	56	6	int:HNF4A
Cytoband	13q21.1	PRR20C PRR20D PRR20B PRR20E PRR20A	2.87e-12	13	56	5	13q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr13q21	PRR20C PRR20D PRR20B PRR20E PRR20A	3.40e-07	117	56	5	chr13q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NUDT19 KMT2B SIPA1L3 PLEKHA4 BRSK1 ALKBH6 CIC	5.98e-04	1192	56	7	chr19q13
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1A KMT2D SETD1B KMT2B	8.18e-07	34	39	4	487
GeneFamily	Ataxins\|Trinucleotide repeat containing	NCOR2 KMT2D	1.32e-03	25	39	2	775
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR2 RERE	5.83e-03	53	39	2	532
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 ARHGEF17	8.91e-03	66	39	2	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHA4 ARHGAP27 PLEKHH3	9.85e-03	206	39	3	682
GeneFamily	PHD finger proteins	KMT2D KMT2B	1.61e-02	90	39	2	88
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PNPLA6 MCTP1 CDCP1 MCOLN1 WDFY4	3.89e-06	199	53	5	22001aa733273e784051b7f750e07d99aaf7a225
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NCOR2 FAM117A PRELP PLEKHA4 CCKBR	3.98e-06	200	53	5	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NCOR2 FAM117A PRELP PLEKHA4 CCKBR	3.98e-06	200	53	5	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
Drug	Acetohexamide [968-81-0]; Up 200; 12.4uM; PC3; HT_HG-U133A	SETD1A KMT2B SIPA1L3 PLD2 SF1 MAPK8IP2	5.49e-06	192	53	6	1829_UP
Drug	Methionine sulfoximine (L) [15985-39-4]; Down 200; 22.2uM; MCF7; HT_HG-U133A	SETD1A PNPLA6 KATNB1 ZNF205 MCOLN1 CIC	5.83e-06	194	53	6	2831_DN
Drug	Cefixime [79350-37-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A	VPS9D1 SETD1A AMH PNPLA6 PLD2 CIC	6.36e-06	197	53	6	3247_UP
Disease	obsolete aging, cognition	PRR20C PRR20D PRR20B PRR20E PRR20A	4.13e-11	15	52	5	EFO_0003925, GO_0007568
Disease	mosaic loss of chromosome Y measurement	PRR20C PRR20D FAM117A PRR20B PRR20E PRR20A	6.05e-09	80	52	6	EFO_0007783
Disease	t-tau:beta-amyloid 1-42 ratio measurement	PRR20C PRR20D PRR20B PRR20E PRR20A	1.15e-07	66	52	5	EFO_0007708
Disease	Tinnitus, wellbeing measurement	PRR20C PRR20D PRR20B PRR20E PRR20A	7.56e-07	96	52	5	EFO_0007869, HP_0000360
Disease	neurodevelopmental disorder with speech impairment and dysmorphic facies (implicated_via_orthology)	SETD1A SETD1B	3.05e-06	2	52	2	DOID:0070417 (implicated_via_orthology)
Disease	telomere length	PRR20C PRR20D PRR20B MCTP1 PRR20E PRR20A	1.83e-05	313	52	6	EFO_0004505
Disease	breast cancer (is_marker_for)	NCOR2 AMH KMT2D KMT2B	3.20e-04	185	52	4	DOID:1612 (is_marker_for)
Disease	migraine disorder, diastolic blood pressure	NCOR2 MEF2D	8.90e-04	25	52	2	EFO_0006336, MONDO_0005277
Disease	congestive heart failure (biomarker_via_orthology)	ADRB3 PLD2 HSF1	9.00e-04	107	52	3	DOID:6000 (biomarker_via_orthology)
Disease	Developmental Disabilities	SETD1A WDFY4	1.28e-03	30	52	2	C0008073

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRSLDSRPPTPPEPD	NT5C1B	186	Q96P26
SRPPTPPEPDPGSRR	NT5C1B	191	Q96P26
DDPTEQPRPPPRPTT	ALKBH6	146	Q3KRA9
EEPPPRSPPESESEP	CDCP1	791	Q9H5V8
PLPPQPTEPSSPERS	CARMIL2	1406	Q6F5E8
PTEPSSPERSPPSPA	CARMIL2	1411	Q6F5E8
PPRTPDSAPPSPAEA	ARHGEF5	511	Q12774
PASPRPPPRKDPEAS	FAM117A	411	Q9C073
PPEESPPAPSRSLAP	ADRB3	246	P13945
RPRALPDEDPPTPSI	CCKBR	416	P32239
DPPERPPPPPSDDLT	MCOLN1	196	Q9GZU1
EPPPSLRSPPETAPE	ARHGEF17	1566	Q96PE2
EGTPPPPPPSRDLTE	NCOR2	1381	Q9Y618
TDEPRETPGRPPDPT	PNPLA6	376	Q8IY17
PERRTADTPSPSPPP	MCTP1	46	Q6DN14
QPRTSDRPPDPLEPP	MAVS	96	Q7Z434
RPETATPPSRPPPAE	NUDT19	26	A8MXV4
SSPASEPEPPREPPR	MAPK8IP2	301	Q13387
PPRRSEPFPAPPEDD	KATNB1	396	Q9BVA0
PPSPPQSPRVEEASP	HSF1	301	Q00613
PPPAARPAGSEPRPE	LRRC24	376	Q50LG9
PPPADDSPAEPEPRA	KMT2B	681	Q9UMN6
FPPPRPSAELEESPP	AMH	271	P03971
LSTPETPPRQPEPPS	HCN4	991	Q9Y3Q4
QPPARPESPPPAERG	PRR20D	61	P86480
QPPARPESPPPAERG	PRR20A	61	P86496
QPPARPESPPPAERG	PRR20B	61	P86481
EDPRRASPPDPSPSP	ICE1	1686	Q9Y2F5
TRASAPPRRPDEPPP	GRID2IP	246	A4D2P6
DSPPSPDPTRPPSRR	GRID2IP	651	A4D2P6
EPRRAPDGTDPPPPH	COBL	1011	O75128
EPANRSPETDPPAPP	CC2D1B	236	Q5T0F9
PPPGRPDPELSSSPR	BRSK1	746	Q8TDC3
PPTGERRFQPPEPPS	NLGN4X	81	Q8N0W4
PQPTDPPASEAPDRP	PRRT3	321	Q5FWE3
EPVSPSRERSPAPPP	MEF2D	441	Q14814
SPASPPEQPPAPEER	PWWP2A	116	Q96N64
EDPPRPTPRPPPSAA	PLEKHH3	571	Q7Z736
SDPTRQETPPPRSPP	PLEKHA4	711	Q9H4M7
AAPPRDPRPSHPEPR	TACO1	26	Q9BSH4
QPPARPESPPPAERG	PRR20C	61	P86479
PGDPRPPTPETDYPE	ARHGAP27	351	Q6ZUM4
QPPARPESPPPAERG	PRR20E	61	P86478
RTEEPPPRPLPFSDP	SIPA1L3	1461	O60292
PRPPSPPPEPETTDA	SETD1B	1331	Q9UPS6
RPTPSFPQPDEPAEP	PRELP	41	P51888
AEEPESPPPPPRSPS	RERE	1101	Q9P2R6
PTEESPPSAPLRPPE	SETD1A	1121	O15047
PAPAPRPDERPSSPI	SETD1A	1141	O15047
PTARSSPPLPPPAEE	CIC	1241	Q96RK0
PPAPREPAPRSDAQP	UBN2	51	Q6ZU65
PPPPRESASRAEQPP	UBN2	106	Q6ZU65
PEDVPRRPEPEPSSS	TTC24	6	A2A3L6
SRDPPDRPRSPDPVD	TNKS	71	O95271
RPAGEEPPAQPPSPR	WDFY4	3111	Q6ZS81
EPSPPPSAPREPDEG	TESK1	551	Q15569
EPDRTPDAAPPDPSP	ZNF205	256	O95201
SPPEPSAAPRPQDSP	VPS9D1	336	Q9Y2B5
PPTPRPDSPATPDLS	PLD2	486	O14939
GIPPNPEDRSPSPEP	SF1	71	Q15637
PPEASRLSPPPEESP	KMT2D	566	O14686
PPEESPLSPPPEASR	KMT2D	611	O14686
SPPPEASRLSPPPED	KMT2D	681	O14686
PPEAEPRPPQSPAST	KIAA1522	896	Q9P206