Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHA6 PDGFRB NTRK1 RET MST1R EPHA10	3.06e-05	65	185	6	GO:0004714
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EPHA6 PDGFRB NTRK1 RET MST1R EPHA10	1.39e-04	85	185	6	GO:0019199
GeneOntologyBiologicalProcess	axon development	KREMEN1 EPHA6 TRIO KALRN SZT2 ACHE NTRK1 CNTNAP1 RET KLF4 STXBP1 MEGF8 PTPRS ROBO3 PALLD CDH11 PLXNA1 NOTCH1 EPHA10	5.05e-06	642	184	19	GO:0061564
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	HEXA EPHA6 TRIO KALRN SZT2 ACHE NTRK1 MINK1 CNTNAP1 RET STXBP1 MEGF8 PTPRS RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 EPHA10	1.26e-05	748	184	20	GO:0048667
GeneOntologyBiologicalProcess	axonogenesis	EPHA6 TRIO KALRN SZT2 ACHE NTRK1 CNTNAP1 RET STXBP1 MEGF8 PTPRS ROBO3 PALLD CDH11 PLXNA1 NOTCH1 EPHA10	1.35e-05	566	184	17	GO:0007409
GeneOntologyBiologicalProcess	neuron projection morphogenesis	EPHA6 TRIO KALRN SZT2 ACHE NTRK1 MINK1 CNTNAP1 RET STXBP1 MEGF8 PTPRS RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 KDM1A EPHA10	3.40e-05	802	184	20	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	EPHA6 TRIO KALRN SZT2 ACHE NTRK1 MINK1 CNTNAP1 RET STXBP1 MEGF8 PTPRS RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 KDM1A EPHA10	4.55e-05	819	184	20	GO:0120039
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	TRIO KALRN PDGFRB ARHGEF5 NTRK1 ITGA3 CBL PLEKHG5 PPP2CB ARHGAP31 ARHGAP27 NOTCH1	4.70e-05	333	184	12	GO:0051056
GeneOntologyBiologicalProcess	cell projection morphogenesis	EPHA6 TRIO KALRN SZT2 ACHE NTRK1 MINK1 CNTNAP1 RET STXBP1 MEGF8 PTPRS RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 KDM1A EPHA10	5.12e-05	826	184	20	GO:0048858
GeneOntologyBiologicalProcess	neuron projection guidance	EPHA6 TRIO KALRN NTRK1 RET MEGF8 ROBO3 PALLD PLXNA1 NOTCH1 EPHA10	5.46e-05	286	184	11	GO:0097485
GeneOntologyBiologicalProcess	neuron development	HEXA KREMEN1 EPHA6 TRIO KALRN SZT2 ACHE NTRK1 PLA2G3 MINK1 CNTNAP1 ITGA3 RET KLF4 RNF220 STXBP1 MEGF8 PTPRS TMEM132E ULK4 RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 KDM1A EPHA10	1.04e-04	1463	184	28	GO:0048666
GeneOntologyBiologicalProcess	ephrin receptor signaling pathway	EPHA6 KALRN NTRK1 NOTCH1 EPHA10	1.19e-04	54	184	5	GO:0048013
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHGC4 PCDHAC1 ITGA3 RET KLF4 PTPRS ROBO3 PCDH10 PALLD CDH11 ADGRL3	1.22e-04	313	184	11	GO:0098742
GeneOntologyBiologicalProcess	cell morphogenesis	HEXA EPHA6 TRIO KALRN SZT2 ACHE NTRK1 MINK1 VPS33A CNTNAP1 RET ST14 STXBP1 MEGF8 PTPRS NBEAL2 RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 KDM1A EPHA10	1.65e-04	1194	184	24	GO:0000902
GeneOntologyBiologicalProcess	phosphatidylinositol 3-kinase/protein kinase B signal transduction	PDE3B PDGFRB GDF15 NTRK1 RET KLF4 CBL MST1R PPP2CA NCOR1 ULK4 NLRC3	1.72e-04	382	184	12	GO:0043491
GeneOntologyBiologicalProcess	neuron projection development	KREMEN1 EPHA6 TRIO KALRN SZT2 ACHE NTRK1 PLA2G3 MINK1 CNTNAP1 ITGA3 RET KLF4 STXBP1 MEGF8 PTPRS ULK4 RERE ROBO3 PALLD CDH11 PLXNA1 NOTCH1 KDM1A EPHA10	1.97e-04	1285	184	25	GO:0031175
GeneOntologyBiologicalProcess	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	PDE3B PDGFRB GDF15 NTRK1 RET KLF4 CBL MST1R PPP2CA NCOR1 NLRC3	2.14e-04	334	184	11	GO:0051896
GeneOntologyCellularComponent	axon	CACNA1C ACHE NTRK1 MINK1 CNTNAP1 ADAM11 ITGA3 RET CBL PLEKHG5 PPP2CA STXBP1 SYT8 PTPRN2 PTPRS ATP6AP2 MAST1 ROBO3 PALLD ADGRL3	1.29e-04	891	185	20	GO:0030424
Domain	Atrophin-like	ATN1 RERE	9.86e-05	2	186	2	IPR002951
Domain	DUF1712	CCZ1B CCZ1	9.86e-05	2	186	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	9.86e-05	2	186	2	IPR013176
Domain	Atrophin-1	ATN1 RERE	9.86e-05	2	186	2	PF03154
Domain	Tyr_kinase_cat_dom	EPHA6 PDGFRB NTRK1 RET MST1R EPHA10	2.48e-04	88	186	6	IPR020635
Domain	TyrKc	EPHA6 PDGFRB NTRK1 RET MST1R EPHA10	2.48e-04	88	186	6	SM00219
Domain	Plexin_repeat	PLXDC1 MST1R MEGF8 PLXNA1	2.75e-04	32	186	4	IPR002165
Domain	PSI	PLXDC1 MST1R MEGF8 PLXNA1	2.75e-04	32	186	4	PF01437
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HEXA LRRC8E PNPLA2 ITPRIPL2 PCNX3 TRIO KALRN SZT2 CHD8 ITGA3 KDM6B KLF4 PLEKHG5 ST14 FANCA ESRP2 MST1R PRR12 NCOR1 KMT2C PPP2CB INTS5 MGAT1 MDN1 GAREM2 MEGF8 ZFP36L2 PTPRS IL17RE NBEAL2 NCAPD2 ULK4 SLC52A2 DMWD DOCK6 GGA1 PLXNA1 NOTCH1 CYB5R2 RAD9A	1.07e-21	1105	189	40	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E CTTNBP2 TRIO KALRN WDR7 DLGAP4 MINK1 CNTNAP1 CHD8 ZNFX1 JAKMIP2 ATF6B NCOR1 PPP2CB MDN1 PTPRN2 PTPRS CCAR1 PRRC2A CDH11 KDM1A FERMT3	1.62e-08	963	189	22	28671696
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	CTTNBP2 ITPRIPL2 KREMEN1 PCNX3 PDGFRB RBM33 DLGAP4 PKD1L1 CHD8 ADAM11 IRGQ RUNX2 IVD RNF220 EXOC5 MGAT1 CCZ1 PTPRS NCAPD2 NEURL1B SLC52A2 ROBO3 NOTCH1 RAD9A	5.40e-08	1215	189	24	15146197
Pubmed	Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.	NTRK1 PPP2CA PPP2CB DOCK6	5.81e-08	8	189	4	23462102
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SZT2 EARS2 CHD8 KDM6B PLEKHG5 URGCP KMT2C INTS5 ARHGAP31 NBEAL2 MDC1 NCAPD2 BOP1 DOCK6 KDM1A	2.38e-07	529	189	15	14621295
Pubmed	Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.	PNPLA2 GDF15 RET	6.29e-07	4	189	3	32661391
Pubmed	Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.	CACNA1C RBFOX3 NTRK1 RET STXBP1	8.03e-07	32	189	5	26758845
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	EXOSC10 ATN1 RBM33 CHD8 KLF4 PRR12 NCOR1 MDC1 RERE KDM1A	2.34e-06	268	189	10	33640491
Pubmed	Adams-Oliver Syndrome – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	ARHGAP31 DOCK6 NOTCH1	3.12e-06	6	189	3	27077170
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM6B KMT2C KDM8 KDM1A	4.70e-06	21	189	4	27626377
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ATN1 KALRN PEG3 NCOR1 RNF220 EXOC5 MEGF8 PTPRN2 SCMH1 RERE PRRC2A NOTCH1 CYB5R2 KLHL26	6.79e-06	608	189	14	16713569
Pubmed	Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.	RBFOX3 EPHA6 ROBO3 PLXNA1	6.90e-06	23	189	4	24360543
Pubmed	Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.	RBFOX3 NTRK1 RET	8.67e-06	8	189	3	23516305
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	EPHA6 RET PCDH10 CDH11 PLXNA1 EPHA10	1.08e-05	91	189	6	28558017
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	PLXDC1 NTRK1 ITGA3 RET PTPRN2 NOTCH1	1.96e-05	101	189	6	23382219
Pubmed	Toward simpler and faster genome-wide mutagenesis in mice.	PCDHAC1 RUNX2 MDC1	2.52e-05	11	189	3	17572674
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CACNA1E TRIO KALRN WDR7 DLGAP4 MINK1 CNTNAP1 KCNB2 STXBP1	2.54e-05	281	189	9	28706196
Pubmed	Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.	ATN1 RERE	2.94e-05	2	189	2	10814707
Pubmed	Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.	PPP2CA PPP2CB	2.94e-05	2	189	2	11751260
Pubmed	Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.	CACNA1C RUNX2	2.94e-05	2	189	2	26553695
Pubmed	Interplay of RUNX2 and KLF4 in initial commitment of odontoblast differentiation.	RUNX2 KLF4	2.94e-05	2	189	2	38720665
Pubmed	Notch-1 regulates proliferation and differentiation of human bladder cancer cell lines by inhibiting expression of Krüppel-like factor 4.	KLF4 NOTCH1	2.94e-05	2	189	2	25109409
Pubmed	Targeting Cadherin-11 Prevents Notch1-Mediated Calcific Aortic Valve Disease.	CDH11 NOTCH1	2.94e-05	2	189	2	28606953
Pubmed	c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.	CBL NOTCH1	2.94e-05	2	189	2	11777909
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	2.94e-05	2	189	2	26858404
Pubmed	Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.	KLF4 NOTCH1	2.94e-05	2	189	2	19074836
Pubmed	JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.	KDM6B KLF4	2.94e-05	2	189	2	33033262
Pubmed	Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.	NTRK1 CBL	2.94e-05	2	189	2	21570973
Pubmed	Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.	PDGFRB MST1R	2.94e-05	2	189	2	19242504
Pubmed	The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.	PPP2CA PPP2CB	2.94e-05	2	189	2	10543450
Pubmed	Expanding the phenotype in Adams-Oliver syndrome correlating with the genotype.	DOCK6 NOTCH1	2.94e-05	2	189	2	31654484
Pubmed	Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.	PPP2CA PPP2CB	2.94e-05	2	189	2	1846293
Pubmed	Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation.	RUNX2 NOTCH1	2.94e-05	2	189	2	20740684
Pubmed	PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.	PPP2CA PPP2CB	2.94e-05	2	189	2	27096707
Pubmed	Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal.	RUNX2 NOTCH1	2.94e-05	2	189	2	36908813
Pubmed	Protein phosphatase 2A effectively modulates basal L-type Ca(2+) current by dephosphorylating Ca(v)1.2 at serine 1866 in mouse cardiac myocytes.	CACNA1C PPP2CA	2.94e-05	2	189	2	22310722
Pubmed	Molecular analysis of the RET and NTRK1 gene rearrangements in papillary thyroid carcinoma in the Polish population.	NTRK1 RET	2.94e-05	2	189	2	16483615
Pubmed	Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.	PPP2CA PPP2CB	2.94e-05	2	189	2	2555176
Pubmed	KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract.	KLF4 NOTCH1	2.94e-05	2	189	2	19109406
Pubmed	Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.	KLF4 NOTCH1	2.94e-05	2	189	2	19717984
Pubmed	Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.	ATN1 KDM1A	2.94e-05	2	189	2	25519973
Pubmed	PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting.	RET CBL	2.94e-05	2	189	2	12727845
Pubmed	MCC-555-induced NAG-1 expression is mediated in part by KLF4.	GDF15 KLF4	2.94e-05	2	189	2	20385121
Pubmed	PI3K/AKT signaling inhibits NOTCH1 lysosome-mediated degradation.	CBL NOTCH1	2.94e-05	2	189	2	26052821
Pubmed	Critical role for Kalirin in nerve growth factor signaling through TrkA.	KALRN NTRK1	2.94e-05	2	189	2	15923627
Pubmed	Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.	PPP2CA PPP2CB	2.94e-05	2	189	2	11113010
Pubmed	c-Cbl is a critical modulator of the Ron tyrosine kinase receptor.	CBL MST1R	2.94e-05	2	189	2	12802274
Pubmed	Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti.	CACNA1C CACNA1E	2.94e-05	2	189	2	12973680
Pubmed	Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.	PPP2CA PPP2CB	2.94e-05	2	189	2	34902541
Pubmed	Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.	PPP2CA PPP2CB	2.94e-05	2	189	2	2837763
Pubmed	KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.	KDM6B NOTCH1	2.94e-05	2	189	2	36797416
Pubmed	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.	RUNX2 PPP2CA PPP2CB	3.35e-05	12	189	3	34079065
Pubmed	Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.	RBFOX3 NTRK1 RET	4.34e-05	13	189	3	35904071
Pubmed	The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1.	RBFOX3 ACHE NTRK1	4.34e-05	13	189	3	22098391
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	RBFOX3 EPHA6 PLXDC1 NTRK1 ADAM11 PLXNA1	4.51e-05	117	189	6	17145500
Pubmed	A high-resolution molecular atlas of the fetal mouse lower urogenital tract.	KREMEN1 PDGFRB ITGA3 SCMH1 KDM1A	5.70e-05	75	189	5	21905163
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PDE3B ATN1 ARHGEF5 MINK1 CHD8 ZNFX1 URGCP POLR3A FANCA PRR12 CCAR1 SLC12A7 PALLD	6.20e-05	650	189	13	38777146
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CACNA1E EXOSC10 RBFOX3 TRIO KALRN CHD8 PRR12 PPP2CA NCOR1 BOP1 PRRC2A	6.38e-05	475	189	11	31040226
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	PDGFRB NTRK1 RET MST1R	6.62e-05	40	189	4	30898150
Pubmed	Trio controls the mature organization of neuronal clusters in the hindbrain.	TRIO CDH11 NOTCH1	6.85e-05	15	189	3	17898204
Pubmed	Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.	RBFOX3 NTRK1 RET	6.85e-05	15	189	3	33722956
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PCNX3 RBM33 MINK1 CHD8 KLF4 PRR12 PPP2CA KMT2C INTS5 MGAT1 MDN1 ZFP36L2 ATP6AP2 MDC1 NCAPD2 CCAR1 BOP1 ZFHX3 ZNF598 PRRC2A KDM1A	7.10e-05	1497	189	21	31527615
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	PNPLA2 ITPRIPL2 RBFOX3 RBM33 DLGAP4 GALNT12 CHD8 ITGA3 NLN INTS5 MDN1 PTPRS SLC12A7 CTSB DOCK6 PLXNA1 NOTCH1	7.46e-05	1061	189	17	33845483
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CCZ1B PPP2CA PPP2CB MDN1 NOTCH1 KDM1A	7.78e-05	129	189	6	23022380
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	8.78e-05	3	189	2	31801062
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	8.78e-05	3	189	2	32160108
Pubmed	Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice.	ACHE NTRK1	8.78e-05	3	189	2	8994044
Pubmed	The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.	RUNX2 POLR3A	8.78e-05	3	189	2	32198086
Pubmed	Promotion of osteoblast differentiation in mesenchymal cells through Cbl-mediated control of STAT5 activity.	RUNX2 CBL	8.78e-05	3	189	2	23533197
Pubmed	Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.	KLF4 NR1I2	8.78e-05	3	189	2	30193838
Pubmed	SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate.	ROBO3 PLXNA1	8.78e-05	3	189	2	33345773
Pubmed	Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.	PPP2CA PPP2CB	8.78e-05	3	189	2	7510677
Pubmed	Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.	ATN1 RERE	8.78e-05	3	189	2	19131340
Pubmed	Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes.	PDGFRB CBL	8.78e-05	3	189	2	18814181
Pubmed	Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta).	PDGFRB CBL	8.78e-05	3	189	2	15753096
Pubmed	GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex.	GDF15 RET	8.78e-05	3	189	2	38254638
Pubmed	Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.	PDGFRB CBL	8.78e-05	3	189	2	17082185
Pubmed	GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.	GDF15 RET	8.78e-05	3	189	2	28846097
Pubmed	GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.	GDF15 RET	8.78e-05	3	189	2	28846099
Pubmed	Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.	NTRK1 RET	8.78e-05	3	189	2	15273715
Pubmed	KLF4 suppresses the proliferation of perihilar cholangiocarcinoma by negatively regulating GDF15 and phosphorylating AKT.	GDF15 KLF4	8.78e-05	3	189	2	37937607
Pubmed	The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.	ST14 MST1R	8.78e-05	3	189	2	17456594
Pubmed	Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells.	PDGFRB KLF4	8.78e-05	3	189	2	19531492
Pubmed	Dual innervation of neonatal Merkel cells in mouse touch domes.	NTRK1 RET	8.78e-05	3	189	2	24637732
Pubmed	Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.	PDGFRB NOTCH1	8.78e-05	3	189	2	18483410
Pubmed	Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.	LCMT2 PPP2CB	8.78e-05	3	189	2	10600115
Pubmed	Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.	NTRK1 STXBP1	8.78e-05	3	189	2	11566499
Pubmed	Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.	PDGFRB CBL	8.78e-05	3	189	2	10347229
Pubmed	The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.	PDGFRB CBL	8.78e-05	3	189	2	10514377
Pubmed	Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.	PPP2CA PPP2CB	8.78e-05	3	189	2	10441131
Pubmed	Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.	PPP2CA PPP2CB	8.78e-05	3	189	2	23341017
Pubmed	Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.	PPP2CA PPP2CB	8.78e-05	3	189	2	15252037
Pubmed	Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.	PDGFRB CBL	8.78e-05	3	189	2	17620338
Pubmed	Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes.	KLF4 NOTCH1	8.78e-05	3	189	2	20442780
Pubmed	Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.	RUNX2 KDM6B	8.78e-05	3	189	2	24106268
Pubmed	Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.	MAST1 NOTCH1	8.78e-05	3	189	2	22101766
Pubmed	Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons.	RBFOX3 CHD8	8.78e-05	3	189	2	30574290
Pubmed	Association of circulating growth differentiation factor-15, Krüppel-like factor 4 and growth arrest-specific 6 with coronary artery disease.	GDF15 KLF4	8.78e-05	3	189	2	31153870
Pubmed	A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.	PDGFRB ST14	8.78e-05	3	189	2	21098708
Pubmed	JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing.	KDM6B NOTCH1	8.78e-05	3	189	2	28747631
Interaction	TOP3B interactions	HEXA LRRC8E PNPLA2 ITPRIPL2 PCNX3 TRIO KALRN SZT2 RBM33 CHD8 ITGA3 KDM6B KLF4 PLEKHG5 ST14 FANCA ESRP2 MST1R PRR12 NCOR1 KMT2C PPP2CB INTS5 MGAT1 MDN1 GAREM2 MEGF8 ZFP36L2 PTPRS IL17RE ATP6AP2 NBEAL2 MDC1 NCAPD2 ULK4 SLC52A2 DMWD ZNF598 DOCK6 GGA1 PRRC2A PLXNA1 NOTCH1 CYB5R2 RAD9A	3.22e-13	1470	184	45	int:TOP3B
Interaction	CFC1 interactions	GALNS GDF15 CNTNAP1 GALNT12 ST14 FUT11 MEGF8 PLXNA1 NOTCH1	2.38e-06	126	184	9	int:CFC1
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	CTTNBP2 MINK1 PPP2CA PPP2CB	1.24e-05	20	133	4	1371
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TRIO KALRN PDGFRB LINGO3 PTPRS ROBO3 PALLD	1.90e-04	161	133	7	593
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	PDGFRB NTRK1 RET MST1R	2.08e-04	40	133	4	321
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6B KDM8 KDM1A	7.03e-04	24	133	3	485
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNDIG1L LRRC10B LINGO3 RUNX2 AK8 MST1R PTPRS HFM1 ROBO3	3.07e-08	160	190	9	237430af14830b38e58da8a4224036e5c6b71c5b
ToppCell	facs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E ADAM11 RUNX2 AK8 PTPRS ARHGAP27 ROBO3 CTSB PALLD	6.03e-08	173	190	9	ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCell	facs-Marrow-T-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E ADAM11 RUNX2 AK8 PTPRS ARHGAP27 ROBO3 CTSB PALLD	6.03e-08	173	190	9	19a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1E SYNDIG1L PEG3 KCNB2 TMEM91 STXBP1 PTPRN2 MAST1 EPHA10	1.23e-07	188	190	9	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB RUNX2 ABCA10 ADAMTS12 PCDH10 PALLD CDH11	1.47e-07	192	190	9	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB RUNX2 ABCA10 ADAMTS12 PCDH10 PALLD CDH11	1.47e-07	192	190	9	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB RUNX2 ABCA10 ADAMTS12 PTPRS NEURL1B PALLD CDH11	1.60e-07	194	190	9	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB RUNX2 ABCA10 ADAMTS12 NEURL1B PALLD CDH11	1.60e-07	194	190	9	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB RUNX2 ABCA10 ADAMTS12 PTPRS NEURL1B PALLD CDH11	1.60e-07	194	190	9	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C CTTNBP2 HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11 ADGRL3	1.68e-07	195	190	9	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB ADAMTS12 ZFHX3 NEURL1B PALLD CDH11 ADGRL3	1.75e-07	196	190	9	b8759e6231e0254797d6c30930407b79440c57bb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB RUNX2 ABCA10 ADAMTS12 NEURL1B PALLD CDH11	1.83e-07	197	190	9	ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB RUNX2 ABCA10 ADAMTS12 NEURL1B PALLD CDH11	1.83e-07	197	190	9	37f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E PLXDC1 GALNT12 ADAM11 RUNX2 AK8 PTPRS ROBO3	8.13e-07	173	190	8	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E PLXDC1 GALNT12 ADAM11 RUNX2 AK8 PTPRS ROBO3	8.13e-07	173	190	8	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	CACNA1C PLXDC1 PDGFRB ISM1 ADAMTS12 ARHGAP31 PALLD CDH11	1.01e-06	178	190	8	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 NTRK1 GALNT12 ADAM11 RUNX2 AK8 PTPRS ROBO3	1.14e-06	181	190	8	fb64da1dde37fe6ba7de2586cd58848ac1974f24
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	CACNA1C KALRN PDGFRB ADAMTS12 NEURL1B DOCK6 CDH11 ADGRL3	1.35e-06	185	190	8	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	CACNA1C EPHA6 ISM1 KCNB2 ABCA10 ADAMTS12 PALLD CDH11	1.46e-06	187	190	8	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB ADAMTS12 NEURL1B PALLD CDH11 ADGRL3	1.64e-06	190	190	8	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB ABCA10 ADAMTS12 NEURL1B PCDH10 PALLD CDH11	1.92e-06	194	190	8	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB ABCA10 ADAMTS12 NEURL1B PCDH10 PALLD CDH11	1.92e-06	194	190	8	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB ISM1 RUNX2 ADAMTS12 PALLD CDH11 ADGRL3	2.00e-06	195	190	8	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNDIG1L CTTNBP2 TRIO WDR7 LRRC10B PEG3 RET PTPRN2	2.00e-06	195	190	8	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB ISM1 RUNX2 ADAMTS12 PALLD CDH11 ADGRL3	2.00e-06	195	190	8	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C PDGFRB HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.07e-06	196	190	8	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C PDGFRB HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.41e-06	200	190	8	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C PDGFRB HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.41e-06	200	190	8	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C PDGFRB HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.41e-06	200	190	8	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	CACNA1C PDGFRB ADAM11 ADAMTS12 PTPRS ROBO3 CDH11	5.57e-06	159	190	7	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPG PARD6G LINGO3 CD8A NEURL1B SLC12A7 GGA1	6.82e-06	164	190	7	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	droplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 RTL5 GALNT12 ADAM11 RUNX2 PTPRS ROBO3	7.38e-06	166	190	7	6e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 RTL5 GALNT12 ADAM11 RUNX2 PTPRS ROBO3	7.38e-06	166	190	7	4fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA6 ASPG NTRK1 PCDHAC1 RUNX2 KCNB2 RASL10A	7.68e-06	167	190	7	3dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA6 ASPG NTRK1 PCDHAC1 RUNX2 KCNB2 RASL10A	7.68e-06	167	190	7	95b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA6 ASPG NTRK1 PCDHAC1 RUNX2 KCNB2 RASL10A	7.68e-06	167	190	7	9480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell	droplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PLXDC1 GALNT12 ADAM11 RUNX2 AK8 ROBO3	7.98e-06	168	190	7	e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PLXDC1 GALNT12 ADAM11 RUNX2 AK8 ROBO3	7.98e-06	168	190	7	32e0bc0873baa13027241063283ef26d2aab56f5
ToppCell	droplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PLXDC1 ADAM11 RUNX2 AK8 PTPRS ROBO3	8.63e-06	170	190	7	749144a1a869a6bf9acdd227184319083367dc3f
ToppCell	droplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PLXDC1 ADAM11 RUNX2 AK8 PTPRS ROBO3	8.63e-06	170	190	7	25d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E PLXDC1 ADAM11 RUNX2 AK8 PTPRS ROBO3	9.31e-06	172	190	7	422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E PLXDC1 ADAM11 RUNX2 AK8 PTPRS ROBO3	9.31e-06	172	190	7	1abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1C PNPLA2 SZT2 RUNX2 LONRF3 CTSB PLXNA1	9.67e-06	173	190	7	20f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C CTTNBP2 ISM1 HIF3A KCNB2 PCDH10 PALLD	1.12e-05	177	190	7	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 ADAM11 RUNX2 PTPRS NEURL1B ROBO3 PALLD	1.16e-05	178	190	7	742ee0cb8cb585a5e34bd5b20aebe9bb99756e0c
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXDC1 PDGFRB ACHE LRRC10B ISM1 HIF3A PPM1N	1.21e-05	179	190	7	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PEG3 CNTNAP1 ISM1 ADAMTS12 PTPRS PALLD CDH11	1.21e-05	179	190	7	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXDC1 PDGFRB ACHE LRRC10B ISM1 HIF3A PPM1N	1.21e-05	179	190	7	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	CACNA1C KALRN PDGFRB ZFHX3 PALLD CDH11 ADGRL3	1.25e-05	180	190	7	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB LINC02898 ADAMTS12 PCDH10 PALLD CDH11	1.30e-05	181	190	7	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	facs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 ADAM11 RUNX2 AK8 PTPRS ARHGAP27 CTSB	1.30e-05	181	190	7	782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell	facs-Marrow-B-cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 ADAM11 RUNX2 AK8 PTPRS ARHGAP27 CTSB	1.30e-05	181	190	7	e2481291c236105774c53883e6f20da11941df9b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIPL2 GALNS LBP FANCA NCAPD2 LONRF3 LY75	1.30e-05	181	190	7	566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIPL2 GALNS LBP FANCA NCAPD2 LONRF3 LY75	1.30e-05	181	190	7	db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB LINC02898 ADAMTS12 PCDH10 PALLD CDH11	1.30e-05	181	190	7	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA1C PLXDC1 PDGFRB ADAMTS12 ZFHX3 NEURL1B CDH11	1.44e-05	184	190	7	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1C CTTNBP2 PDGFRB ISM1 ABCA10 PTPRS CDH11	1.49e-05	185	190	7	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTTNBP2 PARD6G LBP RUNX2 TMCO4 MDN1 RAD9A	1.49e-05	185	190	7	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDGFRB PEG3 ISM1 RUNX2 ADAMTS12 PALLD CDH11	1.49e-05	185	190	7	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 GALNT12 ADAM11 RUNX2 AK8 PTPRS ROBO3	1.49e-05	185	190	7	65dcb0a7ee64990a34a87c167b44497107f035ee
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1C PLXDC1 PDGFRB ADAMTS12 NEURL1B CDH11 ADGRL3	1.55e-05	186	190	7	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PEG3 KCNB2 TMEM91 STXBP1 PTPRN2 MAST1 EPHA10	1.55e-05	186	190	7	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E RBFOX3 KALRN C8orf34 CD8A MAST1 EPHA10	1.55e-05	186	190	7	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	CACNA1C HIF3A ADAMTS12 PTPRS ULK4 PALLD CDH11	1.60e-05	187	190	7	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	CTTNBP2 GDF15 RUNX2 JAKMIP2 ITIH2 PPM1N CDH11	1.60e-05	187	190	7	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	PDGFRB HTRA3 RUNX2 CCIN ADAMTS12 PALLD CDH11	1.60e-05	187	190	7	a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RBFOX3 NTRK1 PAQR6 RUNX2 ZFP36L2 MAST1 KLHL26	1.71e-05	189	190	7	159b0979c93b7d98aaeeb43fba5983a9f67b9c9d
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATN1 ITGA3 KDM6B PPP2CB PRRC2A PALLD NOTCH1	1.71e-05	189	190	7	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIF3A SLC5A11 RNF220 ZFP36L2 ARHGAP31 ZFHX3 NOTCH1	1.71e-05	189	190	7	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RBFOX3 EPHA6 C8orf34 TMEM91 STXBP1 PTPRN2 EPHA10	1.77e-05	190	190	7	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB ABCA10 ADAMTS12 NEURL1B PALLD CDH11	1.83e-05	191	190	7	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	PEG3 HTRA3 HIF3A ADAMTS12 PTPRS PALLD CDH11	1.83e-05	191	190	7	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1C PLXDC1 PDGFRB ADAMTS12 NEURL1B CDH11 ADGRL3	1.83e-05	191	190	7	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB ABCA10 ADAMTS12 NEURL1B PALLD CDH11	1.83e-05	191	190	7	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	1.83e-05	191	190	7	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNA1E RBFOX3 ACHE KCNB2 TMEM91 PTPRN2 MAST1	1.90e-05	192	190	7	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	1.90e-05	192	190	7	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C HIF3A ADAMTS12 PTPRS ULK4 PALLD CDH11	1.96e-05	193	190	7	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	CACNA1C CTTNBP2 HIF3A ADAMTS12 PTPRS PALLD CDH11	1.96e-05	193	190	7	acad568621ed677031797b8c2e34dafea798d681
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB HIF3A ABCA10 ADAMTS12 PTPRS CDH11 ADGRL3	2.03e-05	194	190	7	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB ZFHX3 NEURL1B PALLD CDH11 ADGRL3	2.03e-05	194	190	7	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 PDGFRB RUNX2 ADAMTS12 NEURL1B PALLD CDH11	2.10e-05	195	190	7	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	CACNA1C PDGFRB HIF3A ADAMTS12 PTPRS PALLD CDH11	2.10e-05	195	190	7	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB ADAMTS12 NEURL1B PALLD CDH11 ADGRL3	2.10e-05	195	190	7	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PDE3B EPHA6 HIF3A ABCA10 PTPRS ZFHX3 ADGRL3	2.10e-05	195	190	7	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PEG3 RET NCOR1 KMT2C STXBP1 PTPRN2 RERE	2.10e-05	195	190	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	CACNA1C HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.10e-05	195	190	7	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CACNA1C PDGFRB HIF3A ADAMTS12 SCMH1 PALLD CDH11	2.17e-05	196	190	7	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RBFOX3 KALRN PDGFRB HIF3A PALLD CDH11 ADGRL3	2.17e-05	196	190	7	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB ADAMTS12 PALLD CDH11 ADGRL3	2.17e-05	196	190	7	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLXDC1 KALRN PDGFRB ADAMTS12 PALLD CDH11 ADGRL3	2.17e-05	196	190	7	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RBFOX3 KALRN PDGFRB HIF3A PALLD CDH11 ADGRL3	2.17e-05	196	190	7	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	droplet-Tongue-nan-3m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPG RUNX2 JAKMIP2 ST14 PALLD PPM1N CYB5R2	2.17e-05	196	190	7	159061fd0961b2cfb5941d403acc5b395dd0d3a0
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C HIF3A ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.17e-05	196	190	7	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C PDGFRB ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.24e-05	197	190	7	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	CACNA1C PDGFRB HIF3A ABCA10 ADAMTS12 PTPRS CDH11	2.31e-05	198	190	7	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLXDC1 PDGFRB HTRA3 ADAMTS12 PALLD CDH11 PLXNA1	2.31e-05	198	190	7	eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C PDGFRB ABCA10 ADAMTS12 PTPRS PALLD CDH11	2.31e-05	198	190	7	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C RBFOX3 KALRN PEG3 KCNB2 STXBP1 PTPRN2	2.31e-05	198	190	7	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TRIO PLEKHG5 KMT2C STXBP1 DOCK6 NOTCH1 ADGRL3	2.47e-05	200	190	7	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Drug	Oxethazaine [126-27-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	GPR137 PNPLA2 ATN1 TRIO DLGAP4 MINK1 KDM6B ST6GALNAC2 ZFP36L2 ZFHX3 DOCK6	6.73e-07	194	188	11	4246_DN
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; PC3; HT_HG-U133A	GPR137 PNPLA2 ATN1 MINK1 PEG3 KDM6B ST6GALNAC2 ZFP36L2 ZFHX3 KDM8 RERE	6.73e-07	194	188	11	4242_DN
Drug	Flumethasone [2135-17-3]; Up 200; 9.8uM; PC3; HT_HG-U133A	ATN1 KALRN SZT2 DLGAP4 MINK1 DUOX1 MEGF8 ZFHX3 RERE DMWD	5.37e-06	195	188	10	4272_UP
Drug	Picotamide monohydrate [80530-63-8]; Up 200; 10.2uM; MCF7; HT_HG-U133A	GPR137 ATN1 MINK1 PEG3 SIRT4 SPTBN5 MST1R CD8A RERE CDH11	5.62e-06	196	188	10	2233_UP
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	ATN1 TRIO DLGAP4 MINK1 PEG3 KDM6B ZFP36L2 ZFHX3 RERE ROBO3	5.62e-06	196	188	10	4227_DN
Drug	fullerene C60	CACNA1E TRIO PLXDC1 KALRN PDGFRB ACHE GDF15 LRRC10B MTERF3 HTRA3 HIF3A RUNX2 KDM6B IVD NCOR1 SYT8 ZFP36L2 ARHGAP31 SCMH1 ATP6AP2 NFKBIA CYB5R3 OSBP2 TTC22 ARHGAP27 SLC12A7 PCDH10 PRRC2A MRPL1 UBXN10	5.69e-06	1498	188	30	ctd:C069837
Drug	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	ATN1 GDF15 KDM6B PRR12 ZFHX3 RERE NOTCH1	2.53e-05	104	188	7	ctd:C000595015
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; PC3; HT_HG-U133A	ATN1 SZT2 DLGAP4 MINK1 KLF4 MEGF8 ZFHX3 OSBP2 DMWD	3.00e-05	190	188	9	4274_UP
Drug	Imatinib	PDGFRB NTRK1 RET	3.01e-05	8	188	3	DB00619
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A	PDE3B ACHE ADAMTS12 MEGF8 PTPRN2 DOCK6 ADGRL3 WDR62 KLHL26	3.53e-05	194	188	9	4531_UP
Drug	Dobutamine hydrochloride [49745-95-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	GPR137 ATN1 DLGAP4 HIF3A MEGF8 ZFP36L2 KDM8 DOCK6 KLHL26	3.67e-05	195	188	9	5386_UP
Drug	5666823; Down 200; 100uM; MCF7; HG-U133A	GPR137 DLGAP4 RET KCNB2 RASL10A NBEAL2 DMWD DOCK6 GGA1	3.67e-05	195	188	9	609_DN
Drug	oxaprozin; Down 200; 300uM; MCF7; HT_HG-U133A_EA	GPR137 MTG1 PDE3B TRIO MINK1 RET ZFP36L2 NBEAL2 GGA1	3.67e-05	195	188	9	863_DN
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; MCF7; HT_HG-U133A	GPR137 PNPLA2 DLGAP4 RUNX2 SPTBN5 ZFP36L2 OSBP2 KDM8 DOCK6	3.82e-05	196	188	9	5985_UP
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	GPR137 ATN1 SZT2 DLGAP4 GALNT12 CD8A ZFP36L2 LONRF3 DMWD	3.98e-05	197	188	9	4134_UP
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; PC3; HT_HG-U133A	ATN1 SZT2 RET RUNX2 MEGF8 PTPRN2 ZFHX3 RERE TTC22	3.98e-05	197	188	9	4266_UP
Drug	Flunisolide [3385-03-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TRIO WDR7 DLGAP4 KDM6B JAKMIP2 FANCA ZFP36L2 LONRF3 DOCK6	4.14e-05	198	188	9	6023_DN
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HG-U133A	PNPLA2 TRIO SZT2 RUNX2 CBL ST14 RNF220 SLC52A2 PLXNA1	4.14e-05	198	188	9	387_DN
Drug	Guanadrel sulfate [22195-34-2]; Up 200; 7.6uM; HL60; HT_HG-U133A	PDE3B KALRN NTRK1 DLGAP4 VPS33A ST14 MEGF8 KDM8 SLC12A7	4.48e-05	200	188	9	2575_UP
Disease	Adams Oliver syndrome	ARHGAP31 DOCK6 NOTCH1	4.78e-06	6	185	3	C0265268
Disease	Congenital defect of skull and scalp	ARHGAP31 DOCK6 NOTCH1	4.78e-06	6	185	3	C2931779
Disease	Adams-Oliver syndrome 1	ARHGAP31 DOCK6 NOTCH1	4.78e-06	6	185	3	C4551482
Disease	Adams-Oliver syndrome (is_implicated_in)	ARHGAP31 DOCK6 NOTCH1	4.78e-06	6	185	3	DOID:0060227 (is_implicated_in)
Disease	Colorectal Carcinoma	GALNS KALRN PEG3 GALNT12 RET ZNF232 KCNB2 JAKMIP2 C8orf34 ABCA10 KMT2C ZFP36L2 PTPRN2 PTPRS CCAR1 B4GALNT2	9.93e-06	702	185	16	C0009402
Disease	dentatorubral-pallidoluysian atrophy (implicated_via_orthology)	ATN1 RERE	3.91e-05	2	185	2	DOID:0060162 (implicated_via_orthology)
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B VPS33A CCZ1	8.39e-05	14	185	3	DOID:3753 (implicated_via_orthology)
Disease	Familial medullary thyroid carcinoma	NTRK1 RET	1.17e-04	3	185	2	C1833921
Disease	Intellectual Disability	HEXA CACNA1E ATN1 TRIO PDGFRB CHD8 KDM6B PRR12 PPP2CA KMT2C WDR62	1.30e-04	447	185	11	C3714756
Disease	Global developmental delay	CACNA1E ATN1 SZT2 PRR12 PPP2CA KDM1A	1.99e-04	133	185	6	C0557874
Disease	Adams-Oliver syndrome	ARHGAP31 DOCK6	2.33e-04	4	185	2	cv:C0265268
Disease	myeloproliferative neoplasm (implicated_via_orthology)	PDGFRB CBL	2.33e-04	4	185	2	DOID:2226 (implicated_via_orthology)
Disease	Bladder Neoplasm	ACHE FANCA NCOR1 KMT2C SLC12A7 NOTCH1	2.62e-04	140	185	6	C0005695
Disease	Malignant neoplasm of urinary bladder	ACHE FANCA NCOR1 KMT2C SLC12A7 NOTCH1	2.72e-04	141	185	6	C0005684
Disease	intraocular pressure measurement	SYNDIG1L PNPLA2 EXOSC10 CTTNBP2 KREMEN1 KALRN RUNX2 FANCA ZFP36L2 ZFHX3 CDH11	3.94e-04	509	185	11	EFO_0004695
Disease	Hirschsprung's disease (is_marker_for)	ACHE NTRK1	5.77e-04	6	185	2	DOID:10487 (is_marker_for)
Disease	epilepsy (implicated_via_orthology)	CACNA1E TRIO KALRN MINK1 ITGA3 SLC12A7	5.89e-04	163	185	6	DOID:1826 (implicated_via_orthology)
Disease	breast carcinoma (is_marker_for)	PDGFRB KDM6B MDC1 ZFHX3	7.96e-04	66	185	4	DOID:3459 (is_marker_for)
Disease	lymphocyte count	PCDHGC4 PLXDC1 KALRN NTRK1 MINK1 HIF3A CBL MST1R NCOR1 CD8A ZFP36L2 ARHGAP31 SIGIRR NFKBIA HFM1 RERE NEURL1B NLRC3 FERMT3 RAD9A	9.18e-04	1464	185	20	EFO_0004587
Disease	thyroid peroxidase antibody measurement	CTTNBP2 KALRN PTPRN2 RERE	1.10e-03	72	185	4	EFO_0005666
Disease	brain infarction (biomarker_via_orthology)	RBFOX3 CD8A CTSB	1.15e-03	33	185	3	DOID:3454 (biomarker_via_orthology)
Disease	Liver Diseases, Parasitic	PEG3 KMT2C	1.37e-03	9	185	2	C0023897
Disease	Giant Cell Glioblastoma	NCOR1 NFKBIA CTSB NOTCH1	1.95e-03	84	185	4	C0334588
Disease	Congenital Abnormality	KLF4 NOTCH1	2.07e-03	11	185	2	C0000768
Disease	meningitis	CACNA1E RERE	2.07e-03	11	185	2	MONDO_0021108
Disease	Macrocephaly	CACNA1E CHD8	2.07e-03	11	185	2	C0221355
Disease	volumetric bone mineral density	CACNA1C CACNA1E RSKR	2.33e-03	42	185	3	EFO_0007620
Disease	Gastric Adenocarcinoma	PDGFRB MINK1 EPHA10	2.84e-03	45	185	3	C0278701
Disease	Osteosarcoma	RUNX2 MST1R NR1I2	3.21e-03	47	185	3	C0029463
Disease	congenital hypothyroidism (implicated_via_orthology)	RUNX2 DUOX1	3.39e-03	14	185	2	DOID:0050328 (implicated_via_orthology)
Disease	Adenoid Cystic Carcinoma	KDM6B FANCA KMT2C NOTCH1	3.67e-03	100	185	4	C0010606
Disease	primary autosomal recessive microcephaly (is_implicated_in)	NCAPD2 WDR62	4.43e-03	16	185	2	DOID:0070296 (is_implicated_in)
Disease	smoking cessation	CACNA1E CTTNBP2 RBM33 MST1R STXBP1 ZFHX3 FERMT3	4.57e-03	325	185	7	EFO_0004319
Disease	Sjogren's syndrome (implicated_via_orthology)	ST14 NFKBIA	5.00e-03	17	185	2	DOID:12894 (implicated_via_orthology)
Disease	Myocardial Ischemia	CTTNBP2 GDF15 KLF4 PPP2CA NFKBIA	5.15e-03	176	185	5	C0151744
Disease	Feeding difficulties	ATN1 PPP2CA	5.60e-03	18	185	2	C0232466
Disease	hair colour measurement	GALNS KREMEN1 ASPG DLGAP4 LBP RUNX2 CCNY FANCA ADAMTS12 PLXNA1	5.65e-03	615	185	10	EFO_0007822
Disease	skin sensitivity to sun	FANCA ADAMTS12	6.23e-03	19	185	2	EFO_0004795
Disease	hydrocephalus (implicated_via_orthology)	AK8 ULK4	6.23e-03	19	185	2	DOID:10908 (implicated_via_orthology)
Disease	ovulation	FANCA PRRC2A	6.23e-03	19	185	2	GO_0030728

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPPSRGLFHRAVLQS	ACHE	246	P22303
AFHPARPFLLVASQR	BOP1	586	Q14137
RPPLTRGQFEEARAH	ADAT3	131	Q96EY9
LQGHPEFAVDPRFLA	CHD8	2341	Q9HCK8
LRFPPIRANHSLDVS	CNTNAP1	796	P78357
LLVLANARSRPSFHP	CTSB	11	P07858
PPVIFGRLLRDENLH	CCIN	176	Q13939
NAHPSLYRRPRAIEG	CACNA1E	821	Q15878
LDEPTAGLDPFSRHR	ABCA10	551	Q8WWZ4
EFEHFQRREGLPRPL	B4GALNT2	171	Q8NHY0
PQELRDGFQHPARLV	CCAR1	471	Q8IX12
PREGSRFLVFDHAPF	ARHGEF5	1431	Q12774
FHPSLGPLERERLAL	ATN1	991	P54259
RRIPQDHSESFFPLL	ADGRL3	1326	Q9HAR2
RREGLPEPSDATHLF	ADAM11	316	O75078
ELAALRPGFRLSAPH	C8orf34	11	Q49A92
NLSFPLEPLSRERAH	CCNY	286	Q8ND76
LHAARPSQFRVSPLD	CD8A	16	P01732
PLNEFAFSPDGRHLA	DMWD	286	Q09019
QLPIHRDGFSTLQFP	DLGAP4	111	Q9Y2H0
RFPDRRQEHFIKGLP	ADAMTS12	36	P58397
ALELGAAFPLHAPRR	RGS9BP	96	Q6ZS82
SGEPRFPSHLFLEQR	RBM33	466	Q96EV2
DTRRFRFALPSPQHI	CYB5R3	56	P00387
NTRRFRFGLPSPDHV	CYB5R2	31	Q6BCY4
LSIHFDAPGRPAIFT	RAD9A	236	Q99638
LHVSNIPFRFRDPDL	RBFOX3	101	A6NFN3
LRRHLPFLEALSQAP	PTPRN2	151	Q92932
ELLPSGVTHLRFQRP	DUOX1	1281	Q9NRD9
ARKRFLGPLHPSFNL	PNPLA2	76	Q96AD5
EAQRGLHLDFAPSPF	FAM189A1	261	O60320
VAPDAFHFTPRLSRL	NTRK1	106	P04629
QGFSEFPHLRPVLFL	OR10AC1	16	Q8NH08
AAHDFPLGRQLPSRT	KLF4	301	O43474
RRSPPFNLQIHPFSD	JAKMIP2	596	Q96AA8
RITLPDFTGDLRIPH	LBP	56	P18428
GDTEPLVRHPDFRLF	MDN1	866	Q9NU22
HRIFSNALPDDLRSP	NRBP2	196	Q9NSY0
PPEQLRNSSFHFLRE	NOTCH1	1581	P46531
SNLRHGNFIPRPDFP	KMT2C	2586	Q8NEZ4
HRLDVSLPFVSRGPL	MDC1	131	Q14676
GHPARTVALDRLFLP	NLRC3	116	Q7RTR2
TFQFRGRRVHLAPPL	MGAT1	421	P26572
IEPQGLRFLHVPDTF	ITIH2	216	P19823
DGFSPLLLAVRGRHP	ASPG	466	Q86U10
LVGFFRVHRPPQDLS	GPR137	291	Q96N19
LPRLDSQRHGGPEFS	IL17RE	166	Q8NFR9
SLQHFREQFLVPGRP	KDM8	191	Q8N371
HREGFLGPPASRFSV	KDM6B	521	O15054
HRTNAPFTPRVLLLG	AK8	261	Q96MA6
HDARIPLSGRNPLFQ	MTG1	56	Q9BT17
EPGHLPRVLSFNAAF	PCNX3	1431	Q9H6A9
FHIPGSPARVTALRF	PLXNA1	746	Q9UIW2
PPRLRFAGSESAVFH	ITGA3	526	P26006
FFQIREAPLHPRLSS	PDE3B	266	Q13370
GVFLPRHPQELLASA	CES2	316	O00748
GAVAFSTEDHRPLRP	PPM1N	191	Q8N819
PILTFPARSNHDRIR	KALRN	56	O60229
EPRPRLFHASALLGD	MEGF8	1781	Q7Z7M0
SALPFLDLHGTPRLE	NELFB	46	Q8WX92
HPFFRGVAFDPELLQ	RSKR	356	Q96LW2
AHVEPGAFANLPRLR	LINGO3	91	P0C6S8
FHPLLVSGRLRIPEN	LY75	1036	O60449
RFHGRSRPPLSFNVS	KREMEN1	281	Q96MU8
GFPDLHPLRALRVFS	LRRC10B	196	A6NIK2
LFHFARDPLPGRSDV	GGA1	526	Q9UJY5
FRLHREPDLPGTLLQ	GDPGP1	136	Q6ZNW5
DPELRDFRGNTPLHL	NFKBIA	136	P25963
PEGLPEASRLHRALF	GDF15	111	Q99988
PARLPFSLQVFLRDH	LRRC8E	471	Q6NSJ5
DPGERPRFSQIHSIL	EPHA10	886	Q5JZY3
ISLFSPDRPGVLQHR	NR1I2	346	O75469
PDRVRNLFSLHPTTG	PCDHGC4	286	Q9Y5F7
LFASHLPERLAPGRF	PAQR6	236	Q6TCH4
SHISPRARELFGLSP	PCDH10	291	Q9P2E7
FLQFDPAPRRGEPHV	PPP2CB	286	P62714
FLQFDPAPRRGEPHV	PPP2CA	286	P67775
RPPLAGFVSQRAHSL	IVD	21	P26440
YGRQDLHLRIFDPSP	GTPBP8	61	Q8N3Z3
NSLERAFHSAPGRPA	OSBP2	411	Q969R2
VIHSLPFGEQTFRPR	PEG3	951	Q9GZU2
RQLGLTRDPFPDVVH	MAST1	326	Q9Y2H9
HLDIGLPRDFRPVSS	PARD6G	131	Q9BYG4
SGLRSPLREPGFHFE	PTPRS	1351	Q13332
TPEHQRDFIARDLGP	GBA	291	P04062
ARELELILNRHPPFG	HFM1	961	A2PYH4
RFFRPHFLQAPGDLT	PALLD	1131	Q8WX93
LHIPEFLTPGARFTL	PCDHAC1	131	Q9H158
PGLAVGNLFHRPRAT	ATP6AP2	61	O75787
IFHLGRDPGERFPLS	GALNS	441	P34059
HRLSDPSDLPRNAFR	EXOC5	431	O00471
LPSAERLENVLFGPH	EXOSC10	596	Q01780
LRHPLFGRNVPLSSG	HTRA3	161	P83110
QPIPRLFFAGEHTIR	KDM1A	791	O60341
EEHQRARGPPFLTLS	KCNB2	641	Q92953
YQLPEPGARHFRELT	KLHL26	331	Q53HC5
LLQRSHSPASFPRPF	CACNA1C	2021	Q13936
LPRLHDFAEGPGQRS	DOCK6	1176	Q96HP0
SLHPGLNPRIQAARF	CTTNBP2	436	Q8WZ74
IHVFRNGDLVSPPFS	DCDC2B	131	A2VCK2
PLLQFHRGAPALSRF	FAM83C	451	Q9BQN1
HRGAPALSRFPENGL	FAM83C	456	Q9BQN1
DFRASAAPLPRLAHQ	FUT11	126	Q495W5
RVAPDQHTRLLPFAF	FANCA	1321	O15360
GPQRIPAHRFVLAAG	BTBD1	86	Q9H0C5
SLFPRHIEPELAGRD	CCZ1	251	P86791
FDFPQAPLRGRHTLS	LINC02898	51	Q6ZV80
HAFAPERRGHLRPSF	CDH11	21	P55287
SLFPRHIEPELAGRD	CCZ1B	251	P86790
YHRNPRARLEPFGDV	GALNT12	396	Q8IXK2
VDGLRLFFHPLTPSV	CYP26C1	501	Q6V0L0
SQGERPHLSLFIPRE	C17orf80	346	Q9BSJ5
GRELTNRHSLPFSLP	CBL	611	P22681
RAAARHTPLFPIDDA	B3GNT6	296	Q6ZMB0
NAARYALLRVEHGPP	SLC12A7	671	Q9Y666
PVHDIAFAPNLGRSF	SEH1L	221	Q96EE3
GHPSLQRDFPRSFLL	ISM1	91	B1AKI9
FPGLLFHFPRRSQKD	PKD1L1	2686	Q8TDX9
AAGSPHHRALFPLDR	DIPK1C	226	Q0P6D2
LAARAHFPGPVTRAE	IRGQ	541	Q8WZA9
DHPAILRSQARLPGF	PDGFRB	981	P09619
GLTDHPEFRQPLFFL	OR8B2	16	Q96RD0
TRPARTLLHGFSAQP	MTERF3	31	Q96E29
GFLTGRPLHQRSPNF	PLA2G4D	591	Q86XP0
FLRAGFLNSIQAPHP	EPHA6	716	Q9UF33
RQRFLPGSPRLEGHA	ITPRIPL2	71	Q3MIP1
DHRSRPGRPADFVLL	MINK1	791	Q8N4C8
IEDFPRFPHRGLLLD	HEXA	161	P06865
RREGPAPLHFLLLTD	GAREM2	306	Q75VX8
LFSDRLSDLGRIPHP	RUNX2	241	Q13950
SPLHANFPRFLDEIR	RTL5	211	Q5HYW3
IRQFLFGDYPERHRP	RASL10A	21	Q92737
RFSGHEPLGELRLPL	SYT8	206	Q8NBV8
DNFLTLPPRDHLGLT	SYNDIG1L	151	A6NDD5
APRDLIFRTQFLDHP	SZT2	1261	Q5T011
PHLPTGRELTEANRF	TMCO4	26	Q5TGY1
HTRLAFFLREARPPS	TMEM132E	51	Q6IEE7
SLEPPLGRGAFLSRH	HIF3A	231	Q9Y2N7
HQGPARALRYFDLTP	NBEAL2	571	Q6ZNJ1
LLSEFHPGSDRPQER	NCOR1	71	O75376
RELPEPLFPFSHFRQ	ARHGAP27	776	Q6ZUM4
LSHLPPRFLRSFFLG	SLC52A2	136	Q9HAB3
FPASLGRAELHPVEL	PRRC2A	2041	P48634
GSRVPDGFENRSLPH	POLR3A	806	O14802
PIFITFEGQRRDPAH	SIGIRR	256	Q6IA17
FEGQRRDPAHPALRL	SIGIRR	261	Q6IA17
RHPHFRGLFNLSIPV	ST6GALNAC2	76	Q9UJ37
DRRPIQHGDFVRSAP	SIRT4	86	Q9Y6E7
GLPREDAFHIFRDPL	SLC5A11	251	Q8WWX8
SFHPGLNPLERERLA	RERE	1366	Q9P2R6
GTFANRDFPPSLLHL	RNF220	81	Q5VTB9
LLFVRHPDGRPTGDA	ESRP2	391	Q9H6T0
VHAGTLQPPFTARFL	INTS5	561	Q6P9B9
SSFHLLRRRDPPFQT	PRR12	1076	Q9ULL5
LILDRGFDPSSPVLH	STXBP1	231	P61764
FIHTPGPELQRALAT	PLA2G3	96	Q9NZ20
LARFLRLHSPPEVTN	PLA2G3	401	Q9NZ20
AVRVRFAPSPTGFLH	EARS2	36	Q5JPH6
YGSLRPDRPLHNLAF	SPTBN5	226	Q9NRC6
LPDHFGPARASVVLQ	SCMH1	381	Q96GD3
RLVAGPQFLAFLEPH	ABHD1	41	Q96SE0
GEPQPRRHLLGFSEQ	ATF6B	431	Q99941
HLPPQLRAFQAAFRA	NCAPD2	36	Q15021
FLVSRPEAIHLGPRQ	C11orf71	41	Q6IPW1
FSQPVAGRPSLLRHD	NLN	476	Q9BYT8
LPAGQRRFAHFPGLA	URGCP	636	Q8TCY9
HVRFDLPPQGSVLAR	PLEKHG5	6	O94827
HRPLNLGPFVVRAFL	MRPL1	281	Q9BYD6
ADRPHQRPFLIGVSG	UCK1	16	Q9HA47
LADHVLFPGAPRFLQ	TOMT	241	Q8WZ04
QFGLGDSPRLDHRPQ	WDR97	671	A6NE52
PRAHRLLLPSGALFF	ROBO3	111	Q96MS0
ERRHPGFEATFFQLP	ST14	321	Q9Y5Y6
RRPVLGEAPRFHAQA	NEURL1B	31	A8MQ27
GPDARGLLALRPFHT	PHOSPHO1	151	Q8TCT1
LADARLFFGPQHRPV	FERMT3	86	Q86UX7
FHRSRPGRPQSLILF	ARHGAP31	1336	Q2M1Z3
IRENRPPGTFHQFRL	RET	176	P07949
HLDERPFLRPNIISG	ZNFX1	346	Q9P2E3
ALRLHGSAFRPSLPA	WDR62	1331	O43379
PPFSLFGDLEQHMRR	ZNF598	126	Q86UK7
RHLRYQETPGPREAL	ZNF232	56	Q9UNY5
PTGQRFVRHFRPTDD	UBXN10	206	Q96LJ8
NLPHASRPFILESRF	TEX28	166	O15482
DRRGPTRDFHILFVP	VPS33A	101	Q96AX1
PTSNAALFFIERRPH	PLXDC1	451	Q8IUK5
RQLNSPLHGLERFPD	LCMT2	236	O60294
FGTRDALHLGFPREP	ZFP36L2	236	P47974
AAPQRPAVRHLLGAF	TTC22	61	Q5TAA0
RHALSLIATARPPAF	WDR7	1256	Q9Y4E6
HPGLRRGLDFFQSPS	MST1R	391	Q04912
LTHFLAQGRRLPQPE	MST1R	1296	Q04912
PGRHELGSPLREIAF	TMEM91	26	Q6ZNR0
PILTFPARSNHDRIR	TRIO	86	O75962
PLGHSFRLENPTEFR	ULK4	331	Q96C45
SHGPLDSLRAPFNER	ZFHX3	46	Q15911
LFPGPARASQLRHEG	LONRF3	236	Q496Y0