Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionA-type (transient outward) potassium channel activity

KCND1 KCND2 KCND3

5.63e-0741053GO:0005250
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1S CHRNA2 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

1.33e-0534310510GO:0005261
GeneOntologyMolecularFunctionadenylate cyclase activity

ADCY10 ADCY2 ADCY7

1.09e-04181053GO:0004016
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1S KCNC3 KCND1 KCND2 KCND3 KCNJ4

1.53e-041521056GO:0022843
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1S CHRNA2 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

1.54e-0445910510GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1S RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 SLC5A6 PKD1

1.71e-0446510510GO:0046873
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNC3 KCND1 KCND2 KCND3 KCNJ4

2.03e-041021055GO:0005249
GeneOntologyMolecularFunctioncyclase activity

ADCY10 ADCY2 ADCY7

2.64e-04241053GO:0009975
GeneOntologyMolecularFunctionphosphorus-oxygen lyase activity

ADCY10 ADCY2 ADCY7

2.99e-04251053GO:0016849
GeneOntologyMolecularFunctionoutward rectifier potassium channel activity

KCND1 KCND2 KCND3

3.77e-04271053GO:0015271
GeneOntologyMolecularFunctiongated channel activity

CACNA1S CHRNA2 RYR3 KCNC3 KCND1 KCND2 KCND3 KCNJ4

3.85e-043341058GO:0022836
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1S KCNC3 KCND1 KCND2 KCND3 KCNJ4

4.03e-041821056GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1S KCNC3 KCND1 KCND2 KCND3 KCNJ4

4.27e-041841056GO:0022832
GeneOntologyMolecularFunctionchannel activity

CACNA1S CHRNA2 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

4.48e-0452510510GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1S CHRNA2 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

4.54e-0452610510GO:0022803
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 3-kinase activity

PIK3CA PIK3CG

5.65e-0471052GO:0035005
GeneOntologyMolecularFunction1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

PIK3CA PIK3CG

5.65e-0471052GO:0046934
GeneOntologyMolecularFunctionpotassium channel activity

KCNC3 KCND1 KCND2 KCND3 KCNJ4

5.79e-041281055GO:0005267
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1S CHRNA2 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 SLC5A6 PKD1

7.42e-0466410511GO:0008324
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1S ABCC11 CHRNA2 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 SLC25A39 KCNJ4 SLC5A6 PKD1 SLC2A11 SLC16A10

1.27e-03118010515GO:0022857
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase activity

PIK3CA PIK3CG

1.46e-03111052GO:0016303
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1S RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 SLC5A6 PKD1

1.72e-0362710510GO:0022890
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNC3 KCND1 KCND2 KCND3 KCNJ4

1.90e-031671055GO:0015079
GeneOntologyMolecularFunctionG protein-coupled purinergic nucleotide receptor activity

P2RY1 P2RY4

2.06e-03131052GO:0045028
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1S ABCC11 RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4 SLC5A6 PKD1

2.14e-0375810511GO:0015318
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8H2 OR9G1 MC4R SSTR1 OR51F2 P2RY1 P2RY4 CXCR4 ADGRF5 OR52K2 ADGRF1 GPRC5B

2.34e-0388410512GO:0004930
GeneOntologyBiologicalProcesscAMP biosynthetic process

ADCY10 ADCY2 ADCY7

2.17e-05111073GO:0006171
GeneOntologyBiologicalProcessorganophosphate metabolic process

ADCY10 ENPP6 DDIT4 HK3 PDGFB INPP1 LYST ADCY2 LDLR ADCY7 DIP2A P2RY1 PIK3CA PIK3CG SOCS5 PRKAA2 SERINC4 ADGRF5

2.24e-05114210718GO:0019637
GeneOntologyBiologicalProcessresponse to purine-containing compound

CACNA1S RYR3 SLC6A4 P2RY1 P2RY4 PIK3CG PRKAA2

2.56e-051661077GO:0014074
GeneOntologyBiologicalProcesscellular response to purine-containing compound

CACNA1S RYR3 P2RY1

4.74e-05141073GO:0071415
GeneOntologyBiologicalProcessphospholipid metabolic process

ENPP6 PDGFB INPP1 LYST LDLR PIK3CA PIK3CG SOCS5 SERINC4 ADGRF5

5.46e-0541010710GO:0006644
GeneOntologyBiologicalProcesscellular response to organic cyclic compound

CACNA1S DDIT4 PDGFB SSTR1 ADCY2 TRIP4 RYR3 SLC6A4 PDE12 P2RY1 P2RY4 PIK3CG

7.13e-0560510712GO:0071407
GeneOntologyBiologicalProcessmonoatomic ion transport

CACNA1S IL16 PDGFB ABCC11 CHRNA2 RYR3 SLC6A4 P2RY1 KCNC3 P2RY4 KCND1 KCND2 KCND3 CXCR4 PIK3CG KCNJ4 SLC5A6 PKD1 KEL

7.66e-05137410719GO:0006811
GeneOntologyBiologicalProcessresponse to nitrogen compound

UBR1 CACNA1S MC4R JKAMP LDLR CHRNA2 RYR3 SLC6A4 PDE12 P2RY1 P2RY4 PIK3CA CXCR4 PIK3CG SOCS5 PRKAA2 PHIP TP73

9.08e-05127210718GO:1901698
GeneOntologyBiologicalProcessorganophosphate biosynthetic process

ADCY10 PDGFB INPP1 ADCY2 ADCY7 DIP2A P2RY1 PIK3CA PIK3CG SOCS5 SERINC4 ADGRF5

1.28e-0464410712GO:0090407
GeneOntologyBiologicalProcessmuscle system process

ADCY10 CACNA1S BBS2 RYR3 P2RY1 KCND2 KCND3 PIK3CA CXCR4 PIK3CG TBCE

1.29e-0454710711GO:0003012
GeneOntologyBiologicalProcessstriated muscle contraction

ADCY10 CACNA1S RYR3 KCND3 PIK3CA CXCR4 PIK3CG

1.39e-042171077GO:0006941
GeneOntologyBiologicalProcessprotein complex oligomerization

RYR3 KCNC3 KCND1 KCND2 KCND3 PKD1 TP73 KIF25

1.56e-042961078GO:0051259
GeneOntologyBiologicalProcesscellular response to ATP

RYR3 P2RY1 P2RY4

1.69e-04211073GO:0071318
GeneOntologyBiologicalProcessresponse to caffeine

CACNA1S RYR3 PRKAA2

1.69e-04211073GO:0031000
GeneOntologyBiologicalProcessmetal ion transport

CACNA1S IL16 PDGFB RYR3 SLC6A4 KCNC3 KCND1 KCND2 KCND3 CXCR4 PIK3CG KCNJ4 SLC5A6 PKD1 KEL

2.00e-04100010715GO:0030001
GeneOntologyBiologicalProcesscyclic nucleotide biosynthetic process

ADCY10 ADCY2 ADCY7

2.23e-04231073GO:0009190
GeneOntologyBiologicalProcessmuscle contraction

ADCY10 CACNA1S BBS2 RYR3 KCND2 KCND3 PIK3CA CXCR4 PIK3CG

2.38e-044001079GO:0006936
GeneOntologyBiologicalProcesscAMP metabolic process

ADCY10 ADCY2 ADCY7

2.87e-04251073GO:0046058
GeneOntologyBiologicalProcessprotein tetramerization

RYR3 KCNC3 PKD1 TP73 KIF25

3.08e-041131075GO:0051262
GeneOntologyBiologicalProcessresponse to organic cyclic compound

CACNA1S DDIT4 PDGFB SSTR1 ADCY2 TRIP4 RYR3 SLC6A4 PDE12 P2RY1 P2RY4 PIK3CA CXCR4 PIK3CG PRKAA2

3.30e-04104810715GO:0014070
GeneOntologyBiologicalProcessphosphatidylinositol phosphate biosynthetic process

INPP1 PIK3CA PIK3CG SOCS5

3.85e-04661074GO:0046854
GeneOntologyBiologicalProcessconditioned place preference

SLC6A4 CSMD1

3.95e-0461072GO:1990708
GeneOntologyBiologicalProcesscirculatory system process

ADCY10 PDGFB BBS2 SLC6A4 P2RY1 KCND2 KCND3 PIK3CA CXCR4 PIK3CG SLC5A6 KEL

4.19e-0473310712GO:0003013
GeneOntologyCellularComponentdendrite

USP50 ADCY10 PCSK5 CACNA1S PDGFB FAT3 LAMA2 ADCY2 DIP2A SHANK2 P2RY1 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PRKAA2

1.88e-0685810817GO:0030425
GeneOntologyCellularComponentdendritic tree

USP50 ADCY10 PCSK5 CACNA1S PDGFB FAT3 LAMA2 ADCY2 DIP2A SHANK2 P2RY1 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PRKAA2

1.94e-0686010817GO:0097447
GeneOntologyCellularComponentdendritic spine

USP50 CACNA1S LAMA2 DIP2A SHANK2 KCNC3 KCND1 KCND2 KCND3

4.65e-062421089GO:0043197
GeneOntologyCellularComponentneuron spine

USP50 CACNA1S LAMA2 DIP2A SHANK2 KCNC3 KCND1 KCND2 KCND3

5.49e-062471089GO:0044309
GeneOntologyCellularComponentbasal part of cell

ADCY10 EPPK1 PDGFB LDLR P2RY1 P2RY4 KCNJ4 SLC5A6 PKD1 SLC16A10

2.67e-0537810810GO:0045178
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1S PORCN CHRNA2 RYR3 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

2.67e-0537810810GO:0034702
GeneOntologyCellularComponentcation channel complex

CACNA1S RYR3 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

3.03e-052351088GO:0034703
GeneOntologyCellularComponentbasolateral plasma membrane

EPPK1 PDGFB LDLR P2RY1 P2RY4 KCNJ4 SLC5A6 PKD1 SLC16A10

4.28e-053201089GO:0016323
GeneOntologyCellularComponentsomatodendritic compartment

USP50 ADCY10 PCSK5 CACNA1S PDGFB FAT3 LAMA2 ADCY2 LDLR DIP2A SHANK2 P2RY1 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PRKAA2

5.53e-05122810818GO:0036477
GeneOntologyCellularComponentbasal plasma membrane

EPPK1 PDGFB LDLR P2RY1 P2RY4 KCNJ4 SLC5A6 PKD1 SLC16A10

9.28e-053541089GO:0009925
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNC3 KCND1 KCND2 KCND3 KCNJ4

1.10e-04911085GO:0008076
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class IB

PIK3CA PIK3CG

1.58e-0441082GO:0005944
GeneOntologyCellularComponentpotassium channel complex

KCNC3 KCND1 KCND2 KCND3 KCNJ4

2.05e-041041085GO:0034705
GeneOntologyCellularComponentpostsynaptic membrane

CHRNA2 SLC6A4 SHANK2 P2RY1 KCNC3 KCND1 KCND2 KCND3 KCNJ4

2.54e-044051089GO:0045211
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1S PORCN CHRNA2 RYR3 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

3.81e-0452310810GO:1902495
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex

PIK3CA PIK3CG SOCS5

4.44e-04291083GO:0005942
GeneOntologyCellularComponenttransporter complex

CACNA1S PORCN CHRNA2 RYR3 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

5.64e-0455010810GO:1990351
GeneOntologyCellularComponentlumenal side of endoplasmic reticulum membrane

ALG9 ALG8 SPPL2C

7.78e-04351083GO:0098553
GeneOntologyCellularComponentsynaptic membrane

CHRNA2 SLC6A4 SHANK2 P2RY1 KCNC3 P2RY4 KCND1 KCND2 KCND3 KCNJ4

8.82e-0458310810GO:0097060
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class I

PIK3CA PIK3CG

9.30e-0491082GO:0097651
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class IA

PIK3CA PIK3CG

9.30e-0491082GO:0005943
GeneOntologyCellularComponentlumenal side of membrane

ALG9 ALG8 SPPL2C

1.96e-03481083GO:0098576
GeneOntologyCellularComponentpostsynapse

USP50 CACNA1S LAMA2 CHRNA2 SLC6A4 DIP2A SHANK2 P2RY1 KCNC3 KCND1 KCND2 KCND3 KCNJ4

2.27e-03101810813GO:0098794
GeneOntologyCellularComponentsarcolemma

CACNA1S LAMA2 RYR3 KCND2 KCND3

3.08e-031901085GO:0042383
GeneOntologyCellularComponentapical part of cell

ADCY10 ABCC11 LDLR SHANK2 P2RY1 P2RY4 SLC5A6 PRKAA2 ADGRF5

3.60e-035921089GO:0045177
DomainShal-type_N

KCND1 KCND2 KCND3

1.88e-0731083IPR021645
DomainK_chnl_volt-dep_Kv4_C

KCND1 KCND2 KCND3

1.88e-0731083IPR024587
DomainDUF3399

KCND1 KCND2 KCND3

1.88e-0731083PF11879
DomainK_chnl_volt-dep_Kv4

KCND1 KCND2 KCND3

1.88e-0731083IPR003975
DomainShal-type

KCND1 KCND2 KCND3

1.88e-0731083PF11601
DomainK_chnl_volt-dep_Kv

KCNC3 KCND1 KCND2 KCND3

1.67e-05271084IPR003968
DomainChannel_four-helix_dom

CACNA1S KCNC3 KCND1 KCND2 KCND3

1.94e-05571085IPR027359
Domain-

CACNA1S KCNC3 KCND1 KCND2 KCND3

1.94e-055710851.20.120.350
DomainVG_K_chnl

KCNC3 KCND1 KCND2 KCND3

3.80e-05331084IPR028325
DomainIon_trans_dom

CACNA1S RYR3 KCNC3 KCND1 KCND2 KCND3

5.23e-051141086IPR005821
DomainIon_trans

CACNA1S RYR3 KCNC3 KCND1 KCND2 KCND3

5.23e-051141086PF00520
Domain-

ADCY10 ADCY2 ADCY7

1.44e-041810833.30.70.1230
DomainNucleotide_cyclase

ADCY10 ADCY2 ADCY7

1.44e-04181083IPR029787
DomainGuanylate_cyc

ADCY10 ADCY2 ADCY7

1.70e-04191083PF00211
DomainGUANYLATE_CYCLASE_2

ADCY10 ADCY2 ADCY7

1.70e-04191083PS50125
DomainA/G_cyclase

ADCY10 ADCY2 ADCY7

1.70e-04191083IPR001054
DomainGUANYLATE_CYCLASE_1

ADCY10 ADCY2 ADCY7

1.70e-04191083PS00452
DomainCYCc

ADCY10 ADCY2 ADCY7

1.70e-04191083SM00044
DomainGPCR_2_Ig-hepta-like_rcpt

ADGRF5 ADGRF1

1.97e-0441082IPR008078
DomainPI3K_ABD

PIK3CA PIK3CG

1.97e-0441082PS51544
DomainPI3K_adapt-bd_dom

PIK3CA PIK3CG

1.97e-0441082IPR003113
DomainBTB_2

KCNC3 KCND1 KCND2 KCND3

2.49e-04531084PF02214
DomainT1-type_BTB

KCNC3 KCND1 KCND2 KCND3

2.49e-04531084IPR003131
DomainDMAP_binding

DIP2A DIP2C

3.28e-0451082PF06464
DomainAdcy_conserved_dom

ADCY2 ADCY7

4.89e-0461082IPR009398
DomainDMAP1-bd

DIP2A DIP2C

4.89e-0461082IPR010506
DomainDUF1053

ADCY2 ADCY7

4.89e-0461082PF06327
DomainDMAP_binding

DIP2A DIP2C

4.89e-0461082SM01137
DomainPI3K_Ras-bd_dom

PIK3CA PIK3CG

6.83e-0471082IPR000341
DomainPI3K_rbd

PIK3CA PIK3CG

6.83e-0471082SM00144
DomainPI3K_rbd

PIK3CA PIK3CG

6.83e-0471082PF00794
DomainPI3K_RBD

PIK3CA PIK3CG

6.83e-0471082PS51546
DomainAC_N

ADCY2 ADCY7

9.07e-0481082IPR032628
DomainAdcy

ADCY2 ADCY7

9.07e-0481082IPR030672
DomainPI3K_C2

PIK3CA PIK3CG

9.07e-0481082SM00142
DomainPI3K_C2_dom

PIK3CA PIK3CG

9.07e-0481082IPR002420
DomainPI3K_C2

PIK3CA PIK3CG

9.07e-0481082PF00792
DomainPI3K_C2

PIK3CA PIK3CG

9.07e-0481082PS51547
DomainAC_N

ADCY2 ADCY7

9.07e-0481082PF16214
DomainGPS

PKD1 ADGRF5 ADGRF1

9.88e-04341083SM00303
DomainGPS

PKD1 ADGRF5 ADGRF1

1.08e-03351083PF01825
DomainPI3Ka

PIK3CA PIK3CG

1.16e-0391082PF00613
DomainPI3Ka

PIK3CA PIK3CG

1.16e-0391082SM00145
Domain-

PIK3CA PIK3CG

1.16e-03910821.25.40.70
DomainGPS

PKD1 ADGRF5 ADGRF1

1.17e-03361083PS50221
DomainGPS

PKD1 ADGRF5 ADGRF1

1.27e-03371083IPR000203
DomainPI_Kinase

PIK3CA PIK3CG

1.45e-03101082IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3CA PIK3CG

1.45e-03101082IPR001263
DomainPIK_HELICAL

PIK3CA PIK3CG

1.45e-03101082PS51545
DomainEGF

PCSK5 CD248 DLL4 FAT3 LAMA2 LDLR

2.45e-032351086SM00181
DomainEGF-like_dom

PCSK5 CD248 DLL4 FAT3 LAMA2 LDLR

3.26e-032491086IPR000742
DomainPI3/4_kinase_CS

PIK3CA PIK3CG

3.31e-03151082IPR018936
DomainEGF-type_Asp/Asn_hydroxyl_site

CD248 DLL4 FAT3 LDLR

3.34e-031061084IPR000152
DomainEGF_1

CD248 DLL4 FAT3 LAMA2 LDLR NTN5

3.67e-032551086PS00022
Domain-

PIK3CA PIK3CG

3.77e-031610821.10.1070.11
DomainPI3Kc

PIK3CA PIK3CG

3.77e-03161082SM00146
DomainA/G_cyclase_CS

ADCY2 ADCY7

4.26e-03171082IPR018297
DomainEGF_2

CD248 DLL4 FAT3 LAMA2 LDLR NTN5

4.42e-032651086PS01186
DomainPI3_PI4_kinase

PIK3CA PIK3CG

4.77e-03181082PF00454
DomainPI3_4_KINASE_1

PIK3CA PIK3CG

4.77e-03181082PS00915
DomainPI3_4_KINASE_2

PIK3CA PIK3CG

4.77e-03181082PS00916
DomainPI3/4_kinase_cat_dom

PIK3CA PIK3CG

4.77e-03181082IPR000403
DomainPI3_4_KINASE_3

PIK3CA PIK3CG

4.77e-03181082PS50290
DomainEGF_CA

CD248 DLL4 FAT3 LDLR

5.51e-031221084SM00179
PathwayREACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS

KCND1 KCND2 KCND3

7.54e-067863M27457
PathwayREACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS

KCND1 KCND2 KCND3

7.54e-067863MM15199
PathwayREACTOME_NEURONAL_SYSTEM

ADCY2 CHRNA2 ADCY7 SLC6A4 SHANK2 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PRKAA2

3.88e-054118611M735
PathwayWP_NEOVASCULARIZATION_PROCESSES

PDGFB DLL4 RELB CXCR4

7.31e-0537864M39506
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNC3 KCND1 KCND2 KCND3

1.10e-0441864MM14546
PathwayWP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE

ADCY10 ADCY2 ADCY7

1.16e-0416863M39849
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNC3 KCND1 KCND2 KCND3

1.33e-0443864M1056
PathwayREACTOME_NEURONAL_SYSTEM

ADCY2 CHRNA2 ADCY7 SLC6A4 KCNC3 KCND1 KCND2 KCND3 KCNJ4

2.00e-04335869MM14503
PathwayKEGG_MTOR_SIGNALING_PATHWAY

DDIT4 PIK3CA PIK3CG PRKAA2

2.80e-0452864M7561
PathwayWP_PI3KAKTMTOR_VITAMIN_D3_SIGNALING

HK3 PIK3CA PRKAA2

3.10e-0422863M39345
PathwayREACTOME_POTASSIUM_CHANNELS

KCNC3 KCND1 KCND2 KCND3 KCNJ4

3.27e-0498865MM14545
PathwayWP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION

ADCY10 ADCY2 ADCY7 PDE12

3.47e-0455864M39763
PathwayREACTOME_POTASSIUM_CHANNELS

KCNC3 KCND1 KCND2 KCND3 KCNJ4

4.12e-04103865M1073
PathwayREACTOME_CARDIAC_CONDUCTION

RYR3 KCND1 KCND2 KCND3 KCNJ4

4.12e-04103865MM15196
PathwayWP_CHEMOKINE_SIGNALING

ADCY2 ADCY7 ITK PIK3CA CXCR4 PIK3CG

5.10e-04165866M39400
Pubmed

Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.

IL16 KCND1 KCND2 KCND3 KCNJ4

7.70e-1015108510479680
Pubmed

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.

P2RY1 P2RY4 KCND1 KCND2

3.06e-097108425003238
Pubmed

Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.

KCND1 KCND2 KCND3

2.91e-083108318371079
Pubmed

Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

KCND1 KCND2 KCND3

2.91e-083108310729221
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 EPPK1 KMT2B RELB LYST CDC42BPB LDLR ADCY7 DIP2A SHANK2 DOK4 SLC25A39 CHD5 PKD1 TMEM268 DIP2C ZNF687

5.51e-0811051081735748872
Pubmed

Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.

RELB ADCY2 ADCY7

4.72e-0611108311299302
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1S KCNC3 KCND1 KCND2 KCND3 KCNJ4

5.01e-06139108616985003
Pubmed

Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.

PIK3CA CXCR4 PIK3CG

6.28e-0612108312551992
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNC3 KCND1 KCND2 KCND3

7.37e-0640108416382104
Pubmed

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.

P2RY1 P2RY4 PRKAA2

8.14e-0613108323479225
Pubmed

Cardiac regulation by phosphoinositide 3-kinases and PTEN.

PIK3CA PIK3CG

9.55e-062108219147653
Pubmed

Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.

DIP2A DIP2C

9.55e-062108212137943
Pubmed

AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes.

LDLR PRKAA2

9.55e-062108220167927
Pubmed

Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: tumor capillaries as promising targets.

SSTR1 CXCR4

9.55e-062108229282035
Pubmed

PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

LDLR PIK3CG

9.55e-062108223991137
Pubmed

A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents.

PIK3CA PIK3CG

9.55e-062108217971428
Pubmed

Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome.

KCND2 KCND3

9.55e-062108215563876
Pubmed

Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading.

PLEK2 PIK3CG

9.55e-062108217658464
Pubmed

S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.

KCND1 KCND2

9.55e-062108224675763
Pubmed

Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

KCND2 KCND3

9.55e-062108226196737
Pubmed

Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3.

KCND2 KCND3

9.55e-062108210942109
Pubmed

Severe Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor.

MC4R LDLR

9.55e-062108228030540
Pubmed

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

PRKAA2 PKD1

9.55e-062108226797128
Pubmed

Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice.

LYST LDLR

9.55e-062108215175354
Pubmed

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.

PIK3CA PIK3CG

9.55e-062108233539876
Pubmed

Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.

KCND2 KCND3

9.55e-062108234386734
Pubmed

Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.

DLL4 CXCR4

9.55e-062108218339870
Pubmed

Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling.

PIK3CA PIK3CG

9.55e-062108223142539
Pubmed

Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway.

PIK3CA PKD1

9.55e-062108222227580
Pubmed

Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.

INPP1 SLC6A4

9.55e-062108211901356
Pubmed

Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.

KCND2 KCND3

9.55e-06210829843794
Pubmed

Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor.

MC4R LDLR

9.55e-062108228207798
Pubmed

Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages.

PIK3CA PIK3CG

9.55e-062108219604150
Pubmed

Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.

ITK CXCR4

9.55e-062108215123627
Pubmed

Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.

KCND2 KCND3

9.55e-062108217122053
Pubmed

Neuronal expression of soluble adenylyl cyclase in the mammalian brain.

ADCY10 ADCY2

9.55e-062108223611875
Pubmed

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

ADCY10 ADCY2 ADCY7

1.03e-0514108314993377
Pubmed

Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human.

PDGFB GCAT KCNJ4

1.03e-0514108310384052
Pubmed

Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.

PIK3CA CXCR4 PIK3CG

1.03e-0514108320041213
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

PIK3CA CXCR4 PIK3CG

1.58e-0516108316524887
Pubmed

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.

PIK3CA CXCR4 PIK3CG

1.92e-0517108312960231
Pubmed

Purinergic receptors expressed in human skeletal muscle fibres.

P2RY1 P2RY4

2.86e-053108222052557
Pubmed

Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.

VPS13D CSMD1

2.86e-053108220610895
Pubmed

Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.

KCND2 KCND3

2.86e-053108220371829
Pubmed

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

PIK3CA PIK3CG

2.86e-053108218187452
Pubmed

Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.

KCND2 KCND3

2.86e-053108230758987
Pubmed

Role of heteromultimers in the generation of myocardial transient outward K+ currents.

KCND2 KCND3

2.86e-053108211909823
Pubmed

CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.

DIP2A DIP2C

2.86e-053108217236128
Pubmed

Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization.

PIK3CA PIK3CG

2.86e-053108216840732
Pubmed

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.

DLL4 LDLR

2.86e-053108222699504
Pubmed

I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.

KCND2 KCND3

2.86e-053108222815518
Pubmed

ChIPping away at potassium channel regulation.

KCND1 KCND2

2.86e-053108210700246
Pubmed

A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.

KCND2 KCND3

2.86e-053108222615428
Pubmed

Pituitary adenylate cyclase activating polypeptide reduces expression of Kv1.4 and Kv4.2 subunits underlying A-type K(+) current in adult mouse olfactory neuroepithelia.

KCND1 KCND2

2.86e-053108216426762
Pubmed

Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence.

PIK3CA PIK3CG

2.86e-053108217908814
Pubmed

Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.

P2RY1 P2RY4

2.86e-053108219890001
Pubmed

Sensitivity of AXB/BXA recombinant inbred lines of mice to the locomotor activating effects of cocaine: a quantitative trait loci analysis.

PDGFB SSTR1

2.86e-053108211337941
Pubmed

Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure.

MC4R SLC6A4

2.86e-053108234673574
Pubmed

Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.

PIK3CA PIK3CG

2.86e-053108221035500
Pubmed

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.

LDLR PIK3CG

2.86e-053108218268153
Pubmed

Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophages.

PIK3CA PIK3CG

2.86e-053108217579043
Pubmed

Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo.

LDLR PRKAA2

2.86e-053108220124121
Pubmed

Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.

P2RY1 P2RY4

2.86e-053108212603858
Pubmed

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium.

PDGFB ADGRF5

2.86e-053108226394398
Pubmed

Blocking SDF-1α/CXCR4 downregulates PDGF-B and inhibits bone marrow-derived pericyte differentiation and tumor vascular expansion in Ewing tumors.

PDGFB CXCR4

2.86e-053108224282276
Pubmed

Viability of SH-SY5Y cells is associated with purinergic P2 receptor expression alterations.

P2RY1 P2RY4

2.86e-053108228322086
Pubmed

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1.

PIK3CA PIK3CG

2.86e-053108233159421
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

OR8H2 ENPP6 IL16 FAT3 LDLR TRIP4 GCAT CHD5 CRYBG3 CSMD1 PHIP ZNF687 TP73

4.38e-0511161081331753913
Pubmed

GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion.

CXCR4 PIK3CG

5.71e-054108230018141
Pubmed

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse.

ADGRF5 ADGRF1

5.71e-054108222837050
Pubmed

Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.

P2RY1 P2RY4

5.71e-05410829268704
Pubmed

Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4) to the mouse chromosome 15.

PDGFB KCNJ4

5.71e-05410829271678
Pubmed

Skeletal muscle PI3K p110β regulates expression of AMP-activated protein kinase.

PIK3CA PRKAA2

5.71e-054108227965101
Pubmed

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.

PIK3CA PIK3CG

5.71e-054108232414808
Pubmed

A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

PIK3CA PIK3CG

5.71e-054108223107319
Pubmed

The PI3K inhibitor arsenal: choose your weapon!

PIK3CA PIK3CG

5.71e-054108217920279
Pubmed

Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

KCND2 KCND3

5.71e-054108214980207
Pubmed

Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).

KCND1 KCND2

5.71e-054108215454437
Pubmed

Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro.

P2RY1 P2RY4

5.71e-054108212814360
Pubmed

The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells.

PIK3CA PIK3CG

5.71e-054108214583609
Pubmed

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

LDLR PRKAA2

5.71e-054108221459323
Pubmed

G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.

CXCR4 PIK3CG

5.71e-054108233493514
Pubmed

PI 3-kinase p110beta: a new target for antithrombotic therapy.

PIK3CA PIK3CG

5.71e-054108215834429
Pubmed

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.

PIK3CA PIK3CG

5.71e-054108215932879
Pubmed

Isolated polycystic liver disease genes define effectors of polycystin-1 function.

PKD1 ALG8

5.71e-054108228375157
Pubmed

P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system.

P2RY1 P2RY4

5.71e-054108212151016
Pubmed

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

PIK3CA PIK3CG

5.71e-054108220534549
Pubmed

Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

KCND2 KCND3

5.71e-054108226311767
Pubmed

Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations.

LYST LDLR

5.71e-054108212171798
Pubmed

Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.

KCND2 KCND3

5.71e-054108215662035
Pubmed

Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.

PIK3CA PIK3CG

5.71e-054108223029326
Pubmed

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

PIK3CA PIK3CG

5.71e-054108220847309
Pubmed

IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.

KCND2 KCND3

5.71e-054108226152125
Pubmed

Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.

KCND2 KCND3

9.50e-055108219213956
Pubmed

Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

DDIT4 PIK3CA

9.50e-055108217307335
Pubmed

Absence of apolipoprotein E protects mice from cerebral malaria.

LDLR SLC6A4

9.50e-055108227647324
Pubmed

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.

PIK3CA PIK3CG

9.50e-055108227076174
Pubmed

Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1.

SLC6A4 TP73

9.50e-055108235417707
Pubmed

Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.

P2RY1 P2RY4

9.50e-055108211690642
Pubmed

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.

P2RY1 PIK3CG

9.50e-055108217673465
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY10 ADCY2 ADCY7

8.72e-061077353
GeneFamilyPotassium voltage-gated channels

KCNC3 KCND1 KCND2 KCND3

2.47e-0540774274
GeneFamilyAdhesion G protein-coupled receptors, subfamily F

ADGRF5 ADGRF1

1.78e-045772916
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3CA PIK3CG

4.93e-048772831
GeneFamilyPurinergic receptors P2Y

P2RY1 P2RY4

7.88e-0410772213
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DDIT4 DLL4 PLEK2 CXCR4 ADGRF5

3.01e-0718110874d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DDIT4 DLL4 PLEK2 CXCR4 ADGRF5

3.24e-0718310873427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 PCSK5 DLL4 SSTR1 PLEK2 DLEC1 TP73

3.36e-071841087f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 PCSK5 DLL4 SSTR1 PLEK2 DLEC1 TP73

3.36e-0718410878bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DDIT4 DLL4 PLEK2 CXCR4 ADGRF5

4.32e-0719110873307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

HK3 DLL4 PIK3CA CXCR4 PIK3CG ADGRF5 PHIP

5.51e-071981087af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

HK3 DLL4 PIK3CA CXCR4 PIK3CG ADGRF5 PHIP

5.51e-071981087ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

HK3 DLL4 PIK3CA CXCR4 PIK3CG ADGRF5 PHIP

5.51e-07198108762cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DLL4 SSTR1 PLEK2 DLEC1 TP73

4.99e-061791086a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENPP6 PCSK5 DDIT4 DLL4 PLEK2 CXCR4

6.40e-06187108666ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENPP6 PCSK5 DDIT4 DLL4 PLEK2 CXCR4

6.60e-06188108650b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DDIT4 DLL4 CXCR4 ADGRF5

6.81e-0618910869da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellAdult|World / Lineage, Cell type, age group and donor

HK3 DENND2D FMN1 ADGRF1 MFSD13A SLC16A10

6.81e-0618910865cd285bfad973125d46d704fec18b21266a63379
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 SSTR1 CXCR4 PIK3CG ADGRF5

7.01e-0619010861307688255a1250fa300edf2c41f1affe31dcc98
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PDGFB DLL4 ADGRF5 CRYBG3 GPRC5B

7.23e-06191108604c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PDGFB DLL4 ADGRF5 CRYBG3 GPRC5B

7.23e-061911086db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PDGFB DLL4 ADGRF5 CRYBG3 GPRC5B

7.67e-0619310863a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDIT4 IL16 DENND2D ITK DIP2A CXCR4

8.14e-061951086e1b7ef4ba2ab14d3c839b6305d91efcfd0826220
ToppCell3'-Distal_airway-Immune_Lymphocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDIT4 IL16 DENND2D ITK DIP2A CXCR4

8.14e-0619510864a60b51f92830882872f2fe1a911db2970faf071
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PDGFB DLL4 SSTR1 ADGRF5 CRYBG3

8.87e-0619810865e781583908c4ee107d986904a646a7c6b8e3591
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADCY2 SHANK2 KCND2 CHD5 PKD1 CSMD1

8.87e-061981086c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PDGFB DLL4 SSTR1 ADGRF5 CRYBG3

9.40e-06200108693e13937ec74418a697c37d56f57509fb2154780
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 PDGFB DLL4 CXCR4 CSMD1 GPRC5B

9.40e-06200108677ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCelldistal-3-Endothelial|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PDGFB DLL4 INPP1 SSTR1 SLC6A4 ADGRF5

9.40e-062001086c000264843f611a28a473b5a92195b163f46c4f4
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

RALGAPA1 PCSK5 DLL4 CXCR4 CSMD1 GPRC5B

9.40e-062001086b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

JKAMP PLEK2 CXCR4 DLEC1 TP73

9.42e-0611610851bfd3b0ec4cb5a04c6dfe7861a544eb277e473a3
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

JKAMP PLEK2 CXCR4 DLEC1 TP73

9.42e-061161085a3dcd18807d14e207438f321be62797384fd3907
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

JKAMP PLEK2 CXCR4 DLEC1 TP73

9.42e-061161085685484ea4cbefb5aff5f0cd999fdfadc5a5676e1
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

FAT3 ADCY2 GREB1L KCND2 CSMD1

4.30e-0515910855335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND2D ADCY7 ITK CXCR4 ADGRF1

4.43e-05160108597c899df1b57fd2bd1867e02bfedf1920c00ad17
ToppCelldroplet-Fat-SCAT-30m-Hematologic-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI3 SLC6A4 SLC25A39 SERINC4 KEL

4.43e-05160108567ee7a314d7d4d3ea206e0158083f36f6dd7e80b
ToppCelldroplet-Fat-SCAT-30m-Hematologic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI3 SLC6A4 SLC25A39 SERINC4 KEL

4.43e-051601085759749f708c3a2b36692d42499f19aff937e592f
ToppCelldroplet-Fat-SCAT-30m-Hematologic-erythroblast|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI3 SLC6A4 SLC25A39 SERINC4 KEL

4.43e-051601085fc76337ad766c859db390ef8b6fb9caeaace3a56
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 DDIT4 DLL4 SSTR1 GPRC5B

4.70e-05162108525bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADCY7 KCND3 FMN1 PIK3CG CSMD1

4.70e-05162108580619a93c57fe16daf91dc571874ef9ac888953d
ToppCellIonocyte|World / shred by cell class for turbinate

DLL4 SSTR1 SLC6A4 CXCR4 ADGRF5

5.13e-0516510850cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PELI3 PLEK2 VPS13D ZBED1 GPRC5B

5.28e-0516610859fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCellsevere-CD4+_T_naive|severe / disease stage, cell group and cell class

EPPK1 BBS2 GREB1L THNSL2 SLC16A10

5.43e-05167108502a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCellIIF|World / Disease, Lineage and Cell Type

DDIT4 ZFP57 CXCR4 FMN1 SLC25A39

5.75e-051691085ebf726f725079317ad67c2f754748b4112607277
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PDGFB DLL4 PELI3 CDC42BPB

5.91e-05170108555fe16d98ea284d05fb899888e4569c685644c7b
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFP57 KCND1 CXCR4 SERINC4 DNASE2

6.25e-051721085356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFP57 KCND1 CXCR4 SERINC4 DNASE2

6.25e-05172108546fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFP57 KCND1 CXCR4 SERINC4 DNASE2

6.25e-051721085438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

UBN2 KCND1 PRKAA2 NTN5

6.27e-058810841ca0e16981e88030987412e12838a9797b97b9c9
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 DLL4 SSTR1 DOK4 ADGRF5

6.42e-051731085ad9777e4ae70b11676ec735eb6db91776ca0cb19
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RALGAPA1 PCSK5 DLL4 CHRNA2 ADGRF5

6.60e-05174108540bb87d219aafab0357ab0d797efd38085fc0312
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DDIT4 DLL4 CXCR4

6.96e-05176108527e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DDIT4 DLL4 CXCR4

6.96e-051761085d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 DDIT4 DLL4 SSTR1 GPRC5B

7.15e-0517710855ff8dcfb030312126695d53a026d2e104a401b83
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DLL4 SSTR1 CXCR4 PIK3CG ADGRF5

7.35e-051781085c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 SSTR1 CXCR4 ADGRF5

7.74e-0518010855861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

EPPK1 HK3 PIK3CG DLEC1 VSTM1

8.16e-05182108552eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFB DLL4 DOK4 ADGRF5 MMD

8.16e-051821085b1c1bb1b80c65dea2558051fd5953c1c4a251c1e
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 DLL4 ZFP57 SSTR1 TP73

8.37e-0518310856f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFB DLL4 DOK4 ADGRF5 MMD

8.37e-05183108529defb21458bc43d22ca5e4d08218db45aaa1add
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

LAMA2 NCOA7 ADGRF5 CRYBG3 ADGRF1

8.37e-0518310855c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCell10x5'v1-week_17-19-Hematopoietic-erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RYR3 PLEK2 GCAT SLC25A39 KEL

8.59e-0518410850efc757d9512d6a8fe8176e977a94e4494ed9778
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

LAMA2 P2RY1 PIK3CG SOCS5 CRYBG3

8.59e-05184108567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellControl-Lymphocytic_NKT|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL16 DENND2D ITK CXCR4 MMD

8.81e-05185108559d68e119f58b35bab36294758f6b2e25fd8f5c0
ToppCellfacs-Trachea-nan-24m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DDIT4 PDGFB DLL4 ADGRF5

8.81e-051851085dec60254204014083ff3b4aec0cc75410950a486
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFB DLL4 CXCR4 ADGRF5 GPRC5B

8.81e-051851085602536a3308a848f106adcb0a83530997440c8f4
ToppCellfacs-Trachea-nan-24m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DDIT4 PDGFB DLL4 ADGRF5

8.81e-051851085201465dc0d7aa0336a36d37805cae1155a5adfe1
ToppCellfacs-Trachea-nan-24m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DDIT4 PDGFB DLL4 ADGRF5

8.81e-051851085334f006c3ef33338ff8d649309d3f448733a3a99
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 PCSK5 DLL4 PLEK2 ADGRF5

9.04e-0518610859c7924875f70420720149287c500b4dfa8d24673
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

DLL4 SSTR1 RYR3 CSMD1 GPRC5B

9.04e-0518610852d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 CDC42BPB CHRNA2 DOK4 ADGRF5

9.27e-0518710853548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 CXCR4 PIK3CG ADGRF5

9.27e-05187108529b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 CDC42BPB CHRNA2 DOK4 ADGRF5

9.27e-051871085f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFB DLL4 ADGRF5 CRYBG3 GPRC5B

9.27e-051871085d9d10ed7c905778a29a0dc3ced3eef02a6b1de5c
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 CDC42BPB CHRNA2 DOK4 ADGRF5

9.27e-05187108581754e965848b718be20ee97ce072ce426938a69
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 SSTR1 CXCR4 ADGRF5

9.27e-051871085a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 DDIT4 DLL4 PLEK2 CXCR4

9.50e-0518810855bc1537e079c7435196c163bff5f639ea392a33a
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 CXCR4 PIK3CG ADGRF5

9.50e-051881085b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 PCSK5 DLL4 PLEK2 ADGRF5

9.50e-051881085405efea75233ecf70f7d19b630230798d817b7f2
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFB DLL4 ADGRF5 CRYBG3 GPRC5B

9.74e-051891085db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCellEC-Sinusoidal_ECs|World / Lineage and Cell class

ENPP6 PDGFB DLL4 DOK4 ADGRF5

9.74e-0518910859a0956c8a7069ba3bd0fa56d052d6e514453e578
ToppCellcritical-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FAT3 SLC6A4 ADGRF5 GPRC5B SLC16A10

9.99e-05190108505a2c3549b68f49081723bf35db14974274419d5
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 PDGFB DLL4 DOK4 ADGRF5

9.99e-051901085632d5dc11765053366d61f0a0c7916111cea4f50
ToppCellfacs-SCAT-Fat-18m-Endothelial-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDIT4 PDGFB DLL4 DOK4 ADGRF5

9.99e-051901085b0c9dae8189d407c94964c6bfe3ef92035245357
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 DDIT4 DLL4 PLEK2 ADGRF5

9.99e-051901085eae5bcdb8a35f3fba4d25854c1a43f83f80832a2
ToppCellfacs-SCAT-Fat-18m-Endothelial|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDIT4 PDGFB DLL4 DOK4 ADGRF5

9.99e-051901085ee63dc04e91ad49aa7820c98e97261176ecebaa6
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DLL4 PLEK2 CXCR4

9.99e-051901085d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 DDIT4 DLL4 PLEK2 ADGRF5

9.99e-0519010853346bfd0474828b3729cffa9f4cc57b04dd30443
ToppCellfacs-SCAT-Fat-18m-Endothelial-endothelial_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDIT4 PDGFB DLL4 DOK4 ADGRF5

9.99e-0519010850e50808bfc3d0820524c8470ae3e8250819d65b2
ToppCellCOVID-19-Heart-T_cell|Heart / Disease (COVID-19 only), tissue and cell type

DENND2D ITK SHANK2 CXCR4 CSMD1

9.99e-051901085e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 CXCR4 PIK3CG ADGRF5

9.99e-0519010857ba2be2630183df86de21689289a8620a4cd507e
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT3 SLC6A4 ADGRF5 GPRC5B SLC16A10

1.02e-0419110858f4637e801554e2343b974fe7794f01dd2151418
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PDGFB DLL4 RYR3 ADGRF5

1.02e-041911085b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell-HP_01|World / lung cells shred on cell class, cell subclass, sample id

DDIT4 IL16 NLRP7 ITK CXCR4

1.02e-0419110856b20e6e296e792ad3b95e665ac3d6eb87424ecce
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PDGFB DLL4 CXCR4 PIK3CG ADGRF5

1.02e-041911085e3fc5c92491b6e334abffbf085c00a0b5fa1aed2
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK5 PDGFB DLL4 SSTR1 GPRC5B

1.02e-0419110850b022d8b39eac36115b269aac11a5eaa492754cc
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

UBN2 KCND1 PRKAA2 NTN5

1.03e-041001084cb0deaf1c33d2789417e93cc01d94e34a611d20a
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENPP6 PCSK5 DLL4 PLEK2 CXCR4

1.05e-041921085285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFB DLL4 CXCR4 ADGRF5 GPRC5B

1.05e-0419210855a0615fdc217554ccd611504b16e5d97628e207d
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFB DLL4 CXCR4 PIK3CG ADGRF5

1.05e-0419210851f35efb0765e05f7f9c881849953bef3965be25a
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDIT4 IL16 DENND2D DIP2A CXCR4

1.05e-0419210851922b0350d3375e67c314dbce8074e5cf986f2ef
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ECI1 PLEK2 SLC25A39 ADGRF5 ADGRF1

1.05e-0419210854842a55650fc4687c9184d498a8c05c259d15186
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDIT4 IL16 DENND2D DIP2A CXCR4

1.05e-04192108597c197643e59835c6d45dde9e549c9a1b1bb7288
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDIT4 IL16 DENND2D DIP2A CXCR4

1.05e-041921085a4d161e3d48bc020e687808b352325ef9d1cc1f3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PDGFB DLL4 ADGRF5 GPRC5B

1.05e-04192108556b021c297a21dff357531f21e2464f85186106d
Drugnoradrealine

CACNA1S PORCN ABCC11 ECI1 ADCY2 CHRNA2 ADCY7 RYR3 SLC6A4 SHANK2 P2RY1 PIK3CA PIK3CG PKD1

5.80e-0757510814CID000000951
Drugverapamil

ADCY10 CACNA1S ADCY2 LDLR CHRNA2 ADCY7 RYR3 KCNC3 KCND1 KCND2 KCND3 KCNJ4 PKD1

5.81e-0749010813CID000002520
Drugmyo-inositol

CACNA1S PDGFB DLL4 INPP1 ECI1 ADCY2 CHRNA2 ADCY7 ITK RYR3 P2RY1 P2RY4 PIK3CA PIK3CG PKD1 ALG8

1.38e-0681110816CID000000892
Drugfc21

PDGFB LYST FMN1

2.05e-0661083CID000006370
DrugTetrahydrozoline hydrochloride [522-48-5]; Up 200; 16.8uM; MCF7; HT_HG-U133A

ADCY10 CACNA1S LAMA2 ITK P2RY1 KCND3 CXCR4 KIF25

4.93e-0619910886069_UP
Drugpyraclofos

CACNA1S HK3 KCNC3 KCND1 KCND2 KCND3

1.15e-051061086CID000093460
Drugalprenolol

ADCY10 PDCD2 ECI1 ADCY2 ADCY7

1.34e-05641085CID000002119
Drugphthalic acid

PDGFB LDLR CHRNA2 GCAT CXCR4 MMD

1.35e-051091086CID000001017
Drug8-bromoguanosine 3',5'-cyclic monophosphate

CACNA1S PDCD2 ADCY7 RYR3 SLC6A4 KCNC3 PIK3CA PIK3CG PKD1

1.64e-053081089CID000001915
DrugAC1L1ESQ

IL16 RELB ECI1 LYST CXCR4 TBCE

2.02e-051171086CID000002931
Drugpotassium

CACNA1S RELB ADCY2 CHRNA2 ADCY7 RYR3 P2RY1 KCNC3 KCND1 KCND2 KCND3 PIK3CA PIK3CG KCNJ4 PKD1 SLC16A10

2.14e-05100810816CID000000813
Drugcarbachol

ADCY10 CACNA1S PORCN RELB ADCY2 CHRNA2 ADCY7 RYR3 P2RY1 PIK3CA PIK3CG KCNJ4 PKD1

2.31e-0568810813CID000002551
Drugtriethyltin bromide

HK3 KEL PHIP

2.87e-05131083CID000017701
Drugradicicol; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

RALGAPA1 DDIT4 LDLR ADCY7 DIP2A CXCR4 DIP2C

3.34e-051891087836_UP
Drugbaclofen

ADCY10 CACNA1S ADCY2 ADCY7 RYR3 KCNJ4 PKD1

3.57e-051911087CID000002284
DrugNSC759576

CACNA1S RELB ADCY2 LDLR ADCY7 RYR3 PKD1

3.57e-051911087CID000003075
DrugA3P5PS

P2RY1 P2RY4 CXCR4

3.64e-05141083CID005310943
Drugradicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A

PDGFB CD248 ADCY7 PDE12 KCND3 CXCR4 DIP2C

3.70e-0519210875216_UP
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1S BBS2 RYR3 KCNC3 PKD1

3.73e-05791085CID005287890
Drugsumatriptan

ADCY10 ADCY2 ADCY7 P2RY1 P2RY4

3.96e-05801085CID000005358
DrugProtoveratrine A [143-57-7]; Up 200; 5uM; MCF7; HT_HG-U133A

CACNA1S CD248 SHANK2 P2RY1 KCND3 THNSL2 SLC16A10

4.21e-0519610874963_UP
DrugLorglumide sodium salt [97964-56-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A

P2RY4 KCND3 CXCR4 KCNJ4 KEL FBXO21 KIF25

4.35e-0519710875619_UP
DrugCephalothin sodium salt [58-71-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

IL16 CD248 LAMA2 CHRNA2 P2RY1 KCND3 SLC2A11

4.49e-0519810876079_UP
Drugbutamben

KCND1 KCND2 KCND3

4.53e-05151083CID000002482
Drugestradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

PDGFB INPP1 LYST RNF126 VPS13D CXCR4 GPRC5B

4.64e-051991087988_UP
Druglanthanum

CACNA1S ADCY2 ADCY7 RYR3 KCND1 PKD1

4.72e-051361086CID000023926
Drug2,4-dichloronitrobenzene

LYST CXCR4 PHIP

5.56e-05161083CID000011899
Drugtetracaine

CACNA1S ADCY2 CHRNA2 ADCY7 RYR3

6.27e-05881085CID000005411
Drug(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE

PIK3CA PIK3CG

6.67e-0531082DB08059
Drugisoproterenol

ADCY10 PDCD2 ABCC11 RELB ECI1 ADCY2 CHRNA2 ADCY7 RYR3 P2RY1 P2RY4 KCND3

7.99e-0566910812CID000003779
Drugmanidipine

CACNA1S PDGFB LDLR RYR3 PKD1

9.03e-05951085CID000004008
DrugAC1L1DXE

CACNA1S MC4R BBS2 RYR3 SLC6A4 PIK3CA PIK3CG PKD1

9.11e-052991088CID000002548
DiseaseCystic liver disease

ALG9 ALG8

1.21e-0521032C4551631
Diseasehemangioblastoma (is_marker_for)

DLL4 CXCR4

7.21e-0541032DOID:5241 (is_marker_for)
DiseasePolycystic liver disease

ALG9 ALG8

1.20e-0451032C0158683
Diseasesexual dimorphism measurement

RALGAPA1 PCSK5 EPPK1 KMT2B CD248 MC4R RELB ECI1 LDLR SLC6A4 PKD1 PHIP GPRC5B

1.26e-04110610313EFO_0021796
DiseaseSudden Cardiac Arrest

KCND2 KCND3

3.33e-0481032C1720824
DiseasePolycystic Kidney, Autosomal Dominant

ALG9 PKD1

4.28e-0491032C0085413
Diseaseautistic disorder (is_implicated_in)

SLC6A4 SHANK2 PIK3CG

4.30e-04421033DOID:12849 (is_implicated_in)
Diseasechronic fatigue syndrome (is_marker_for)

IL16 SLC6A4

5.33e-04101032DOID:8544 (is_marker_for)
DiseaseCystic Kidney Diseases

ALG9 ALG8

6.50e-04111032C1691228
Diseasealcohol and nicotine codependence

KCND2 CAPN7

9.18e-04131032EFO_0004776
Diseasesulfate measurement

SLC6A4 P2RY1

1.07e-03141032EFO_0007864
Diseasecongenital disorder of glycosylation type I (implicated_via_orthology)

ALG9 ALG8

1.23e-03151032DOID:0050570 (implicated_via_orthology)
DiseaseOpioid use measurement

NLRP7 KCND3

1.23e-03151032EFO_0009937
DiseaseMalignant neoplasm of breast

HK3 DLL4 LAMA2 RECQL PIK3CA CXCR4 CHD5 PRKAA2 DIP2C DLEC1 TP73

1.33e-03107410311C0006142
Diseaselevel of Sterol ester (27:1/18:1) in blood serum

RELB LDLR

1.40e-03161032OBA_2045195
Diseasejoint damage measurement

RFPL4B CSMD1 TP73

1.76e-03681033EFO_0005413
Diseaseborna disease (biomarker_via_orthology)

IL16 SLC6A4

1.78e-03181032DOID:5154 (biomarker_via_orthology)
DiseaseManic Disorder

ADCY2 SLC6A4 SHANK2

1.99e-03711033C0024713
Diseasejuvenile idiopathic arthritis

INPP1 LAMA2 CXCR4

2.24e-03741033EFO_0002609
DiseaseAutistic Disorder

INPP1 SLC6A4 SHANK2 KCND2 PIK3CG

2.26e-032611035C0004352
Diseasemucocutaneous lymph node syndrome

ENPP6 SHANK2 KIF25

2.41e-03761033EFO_0004246
DiseaseManic

ADCY2 SLC6A4 SHANK2

2.60e-03781033C0338831
DiseaseDepression, Bipolar

ADCY2 SLC6A4 SHANK2

2.69e-03791033C0005587
Diseasesensory peripheral neuropathy, remission

DLEC1 CSMD1

2.91e-03231032EFO_0009785, MONDO_0002321
DiseaseNerve Degeneration

DDIT4 KCNJ4 SLC5A6

3.10e-03831033C0027746
DiseaseAnhedonia

MC4R SLC6A4

3.17e-03241032C0178417

Protein segments in the cluster

PeptideGeneStartEntry
VGLILPGIVILSCYC

CXCR4

206

P61073
CLPGYILEGHAILTC

CSMD1

171

Q96PZ7
QGGEIILCDTCPRAY

CHD5

351

Q8TDI0
LEEGLYADLTSCGCP

CRYBG3

2721

Q68DQ2
VGFCLGYGCPLIISV

ADGRF1

701

Q5T601
GVILYALLCGTLPFD

PRKAA2

201

P54646
FLFPVYPLICLCGAV

ALG9

371

Q9H6U8
YPLICLCGAVALSAL

ALG9

376

Q9H6U8
VLLALGIVYCTRCGP

CD248

701

Q9HCU0
TCRPGYTGVDCELEL

DLL4

311

Q9NR61
CLTVLVFYLPSDCGE

CHRNA2

281

Q15822
LGDCYYCVSGLPVSL

ADCY7

326

P51828
LGEGSCGIPFYCEEL

ADCY10

726

Q96PN6
CGIPFYCEELLKNLE

ADCY10

731

Q96PN6
FFCDLLPLVELACGE

OR9G1

176

Q8NH87
ESGPCTGGEELYLLC

RELB

311

Q01201
ELCYISFCLPKGEVR

FMN1

16

Q68DA7
GYGFRCVTEECPLAV

KCNJ4

136

P48050
VNLPGEVLEYILCCG

FBXO21

31

O94952
AEFALDLILYCGCEG

OGFOD1

456

Q8N543
CLALITGPYVIGFID

OR8H2

141

Q8N162
FCVPLVLILGCYGLI

P2RY1

226

P47900
PCGLQCVTILIGVYD

INPP1

176

P49441
YGLVPELVGDCCLEE

KCND1

121

Q9NSA2
YGILPEIIGDCCYEE

KCND3

121

Q9UK17
LCCYLRLVSAEGDPI

PDGFB

11

P01127
LYDGLCLEECPAGTY

PCSK5

1396

Q92824
CELCGRPLSFLLQVY

PDCD2

51

Q16342
TGFDCPCILLSYILI

OR51F2

221

Q8NH61
VSCDLYPGIPVIFCG

PDE12

481

Q6L8Q7
LGIGLCSVPYFQCIS

IL16

366

Q14005
LFEGVCYGPLVLITC

ABCC11

271

Q96J66
FFGLIPEIIGDCCYE

KCND2

121

Q9NZV8
LIEKCDCPLGYSGLS

LAMA2

1376

P24043
LSDCEGRLFPIGYQC

KMT2B

1746

Q9UMN6
IAPLQEICCLASRYG

GCAT

211

O75600
LCPFFCLELLGEGES

RFPL4B

241

Q6ZWI9
LCVGYPSGFCLLSIQ

CDC42BPB

1386

Q9Y5S2
GRLIFELYCDVCPKT

PPIL6

156

Q8IXY8
CGYEDPRCEIGLIVG

HK3

671

P52790
CEGVFFSGLLLYLCD

GREB1L

1841

Q9C091
YGCLSIGDCVGLIEV

PIK3CA

836

P42336
DGLQELACGGLIYCL

MMD

176

Q15546
GCGLDLLPQYVSLCD

GPRC5B

36

Q9NZH0
GLLFGVPCLVTLVCY

P2RY4

206

P51582
LLCLVLSTCVGPYLF

PORCN

201

Q9H237
FLTGLGCPNCIEYFT

TP73

496

O15350
PAGGCLVALTCDYRI

ECI1

151

P42126
ILGDCYYCVSGLPIS

ADCY2

336

Q08462
FLYVPFLGVCVCGAI

SLC2A11

436

Q9BYW1
ICCSVDGEIRGYLPG

BBS2

306

Q9BXC9
LAALLCVPAGALTCY

DNASE2

6

O00115
RCGFCYLELENIPSG

CAPN7

766

Q9Y6W3
QEILLACSYGKLCDP

CACNA1S

1326

Q13698
YSEPCGLRGALLDVC

DDIT4

136

Q9NX09
LTELKLGCVLYPDAC

FAT3

4011

Q8TDW7
VAICLDPYCGLGFVL

DIP2C

1176

Q9Y2E4
VPICCGLYELLSGVL

LYST

2301

Q99698
IICCYPLGGLCDLSS

MC4R

316

P32245
IAICLDPYCGLGFAL

DIP2A

1191

Q14689
GCEVEILGVRPTYCL

ENPP6

141

Q6UWR7
VLTLSPVLDCGYCLI

DLEC1

476

Q9Y238
APAGLQFLLCLCLYD

MFSD13A

121

Q14CX5
GCFYLLVLVPITCAL

MFSD13A

466

Q14CX5
VFLLPCPNLDVYGEC

DOK4

141

Q8TEW6
PKVYCIISCIGCFGL

DENND2D

151

Q9H6A0
LLDSGCGEEYVACLP

PKD1

171

P98161
LYGVCLEQAPICLVF

ITK

421

Q08881
IPFCLAYTLALLGNC

OR52K2

31

Q8NGK3
LFEAFLEPLGTLGYC

VARS2

941

Q5ST30
GFLLPVGAICLCYVL

SSTR1

231

P30872
VICRCTTYDGIDGLP

SOCS5

491

O75159
PLVIENGCEEYGLIC

NCOA7

256

Q8NI08
LTCGCLRLQPGTDYL

NTN5

416

Q8WTR8
FLGCCYFLGLLIPAH

SLC5A6

101

Q9Y289
PIKYGELIVLGCCEE

PELI3

41

Q8N2H9
LECVKPYLEGSGCIA

EPPK1

1886

P58107
DYICPRCESGFIEEL

RNF126

26

Q9BV68
FGDIVVPGFLVAYCC

SPPL2C

446

Q8IUH8
YPGLVKELCALFIGS

THNSL2

51

Q86YJ6
TGVKFLCEGLSYPDC

NLRP7

861

Q8WX94
VCPLLTSLLDGYNVC

KIF25

46

Q9UIL4
TAIVGGDPYCCELLL

SHANK2

271

Q9UPX8
AFCLGYGCPLAISVI

ADGRF5

1131

Q8IZF2
TFYLLGLGPLEVCCE

ALG8

461

Q9BVK2
ETESLDLCLLPYGCI

PIK3CG

856

P48736
DLCLLPYGCISTGDK

PIK3CG

861

P48736
LCYQLPALCSDGFTL

RECQL

121

P46063
LIEAYILGTGCCPFL

TMEM268

326

Q5VZI3
ILLDGCTITCPCLEY

PLEK2

51

Q9NYT0
CVEFSYPELLLCGEQ

UBN2

141

Q6ZU65
YLCPICDLSFGEKEG

ZFP57

356

Q9NU63
VLLGSLVCFPNLYCE

RALGAPA1

1236

Q6GYQ0
YEVGLPTLCCLKLAF

PHIP

1011

Q8WWQ0
TGKCLLYCNGVLEPL

SLC25A39

71

Q9BZJ4
VLRCVAGCPGLEELY

TBCE

221

Q15813
YEIENGFVPICCLGL

RYR3

1181

Q15413
FLLGLCAIAFCIPDE

SERINC4

161

A6NH21
DLFDLESGEYLCPLC

UBR1

1186

Q8IWV7
CLCSILPLVEYFLTG

USP50

61

Q70EL3
SFGCVASVLGYCLLP

YIPF5

176

Q969M3
LSLLCLGLCLGYEDE

VSTM1

6

Q6UX27
LALPPTGYRCLECGD

ZNF687

526

Q8N1G0
DYPSGCLLGCVDLID

TRIP4

501

Q15650
LTAAVLGLICEGLYP

ZBED1

126

O96006
ILGYCIGTSSFICIP

SLC6A4

576

P31645
ICNLLPCELDFYVKG

VPS13D

3186

Q5THJ4
IFYQLLLPGGCLACD

KEL

586

P23276
CVAILPFYLEVGLSG

KCNC3

386

Q14003
EPLYLTYGIIFACGC

SLC16A10

166

Q8TF71
QPACLGLYCGKTLLF

JKAMP

6

Q9P055
DLKIGYECLCPDGFQ

LDLR

331

P01130