Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

MANEA OGA MANEAL CEMIP

8.46e-05103454GO:0004553
GeneOntologyMolecularFunctionhistone modifying activity

PRDM13 SIRT2 OGA MAP3K7 SMYD2

1.60e-04229455GO:0140993
GeneOntologyMolecularFunctionhyalurononglucosaminidase activity

OGA CEMIP

1.77e-049452GO:0004415
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF1 PRAMEF13 PRAMEF14

2.59e-0455453GO:0042974
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

MANEA OGA MANEAL CEMIP

3.07e-04144454GO:0016798
GeneOntologyMolecularFunctionalpha-mannosidase activity

MANEA MANEAL

5.12e-0415452GO:0004559
GeneOntologyMolecularFunctionmannosidase activity

MANEA MANEAL

5.84e-0416452GO:0015923
GeneOntologyMolecularFunctionhexosaminidase activity

OGA CEMIP

6.61e-0417452GO:0015929
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH17 DNAH1

7.43e-0418452GO:0008569
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF1 PRAMEF13 PRAMEF14

8.36e-0482453GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF1 PRAMEF13 PRAMEF14

1.28e-0395453GO:0140767
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH17 DNAH1

1.81e-0328452GO:0051959
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

PRDM13 SIRT2 PRAMEF1 MAP3K7 PRAMEF13 PRAMEF14

1.85e-03582456GO:0140297
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

SIRT2 PNPLA1 OGA HHAT

2.00e-03238454GO:0016747
GeneOntologyMolecularFunctionephrin receptor binding

EFNA2 LYN

2.36e-0332452GO:0046875
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH17 DNAH1

3.15e-0337452GO:0045505
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

UFSP2 USP38 PRPF8

3.63e-03137453GO:0019783
GeneOntologyMolecularFunctionSH3 domain binding

CBLC SHANK2 LYN

4.10e-03143453GO:0017124
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

IL34 CBLC TPST1 POGLUT3 SIRT2 ACVR1B LYN HHAT SMYD2 PKD1 CEMIP

4.58e-069764411GO:0018193
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

VANGL2 IL34 CBLC CDC25A LYN MAP3K7 CEMIP

9.87e-06358447GO:0071900
GeneOntologyBiologicalProcessregulation of MAP kinase activity

VANGL2 IL34 CBLC LYN MAP3K7

5.64e-05194445GO:0043405
GeneOntologyBiologicalProcessoocyte development

SIRT2 PRAMEF1 PRAMEF13 PRAMEF14

5.85e-0599444GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

SIRT2 PRAMEF1 PRAMEF13 PRAMEF14

6.83e-05103444GO:0009994
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

VANGL2 PRAMEF1 PRAMEF13 PRAMEF14

8.21e-05108444GO:0035019
GeneOntologyBiologicalProcesspositive regulation of cell migration

IL34 ZNF609 ACVR1B LYN MAP3K7 FAM83H CPEB1 CEMIP

9.28e-05691448GO:0030335
GeneOntologyBiologicalProcesspositive regulation of cell motility

IL34 ZNF609 ACVR1B LYN MAP3K7 FAM83H CPEB1 CEMIP

1.29e-04725448GO:2000147
GeneOntologyBiologicalProcesspositive regulation of locomotion

IL34 ZNF609 ACVR1B LYN MAP3K7 FAM83H CPEB1 CEMIP

1.52e-04742448GO:0040017
GeneOntologyBiologicalProcessregulation of protein kinase activity

VANGL2 IL34 CBLC CDC25A LYN MAP3K7 CEMIP

2.86e-04611447GO:0045859
GeneOntologyBiologicalProcessregulation of MAPK cascade

VANGL2 IL34 CBLC PRAMEF1 LYN MAP3K7 PRAMEF13 PRAMEF14

2.88e-04815448GO:0043408
GeneOntologyBiologicalProcessregulation of oligodendrocyte progenitor proliferation

SIRT2 LYN

2.90e-0412442GO:0070445
GeneOntologyBiologicalProcessoogenesis

SIRT2 PRAMEF1 PRAMEF13 PRAMEF14

3.38e-04156444GO:0048477
GeneOntologyBiologicalProcessoligodendrocyte progenitor proliferation

SIRT2 LYN

3.42e-0413442GO:0070444
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF1 PRAMEF13 PRAMEF14

1.41e-0447453GO:0031462
HumanPhenoReduced sperm motility

HYDIN ALG9 DNAH17 DNAH1 PKD1

2.15e-0669175HP:0012207
HumanPhenoAbnormal sperm motility

HYDIN ALG9 DNAH17 DNAH1 PKD1

2.68e-05115175HP:0012206
HumanPhenoAbnormal sperm physiology

HYDIN ALG9 DNAH17 DNAH1 PKD1

2.68e-05115175HP:0034809
HumanPhenoLimb hypertonia

PRDM13 CACNA2D1 UFSP2 TSEN2 PI4KA

1.39e-04162175HP:0002509
HumanPhenoHypertonicity

PRDM13 CACNA2D1 UFSP2 TSEN2 PI4KA

1.39e-04162175HP:0002388
DomainGlyco_Hydrolase_99

MANEA MANEAL

5.18e-062432IPR026071
DomainGlyco_hydro_99

MANEA MANEAL

5.18e-062432PF16317
DomainPRAME_family

PRAMEF1 PRAMEF13

8.64e-0419432IPR026271
DomainCupredoxin

EFNA2 PRPF8

1.16e-0322432IPR008972
DomainSET

PRDM13 SMYD2

5.03e-0346432SM00317
DomainSET_dom

PRDM13 SMYD2

5.91e-0350432IPR001214
DomainSET

PRDM13 SMYD2

5.91e-0350432PS50280
Domain-

PRAMEF1 PRAMEF13 ECM2 PKD1

6.24e-033214343.80.10.10
DomainGlycoside_hydrolase_SF

MANEA OGA

6.62e-0353432IPR017853
DomainL_dom-like

PRAMEF1 PRAMEF13 ECM2 PKD1

6.72e-03328434IPR032675
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF1 PRAMEF13 PRAMEF14

1.63e-061845329731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF1 PRAMEF13 PRAMEF14

1.63e-061845323894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF1 PRAMEF13 PRAMEF14

1.63e-061845314675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF1 PRAMEF13 PRAMEF14

1.63e-061845312890732
Pubmed

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.

SMYD2 PKD1

1.64e-06245228604386
Pubmed

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

SIRT2 PKD1

1.64e-06245224203696
Pubmed

CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response.

MAP3K7 CPEB1

1.64e-06245225452303
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF1 PRAMEF13 PRAMEF14

1.93e-061945328604677
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF1 PRAMEF13 PRAMEF14

2.27e-062045326694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF1 PRAMEF13 PRAMEF14

2.27e-062045316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF1 PRAMEF13 PRAMEF14

2.27e-062045321425410
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF1 PRAMEF13 PRAMEF14

3.06e-062245331729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF1 PRAMEF13 PRAMEF14

3.52e-062345319480014
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF1 PRAMEF13 PRAMEF14

4.56e-062545337451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF1 PRAMEF13 PRAMEF14

4.56e-062545312620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF1 PRAMEF13 PRAMEF14

5.15e-062645318500982
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF1 PRAMEF13 PRAMEF14

6.48e-062845325089626
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF1 PRAMEF13 PRAMEF14

8.02e-063045338786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF1 PRAMEF13 PRAMEF14

9.78e-063245337889087
Pubmed

cbl-3: a new mammalian cbl family protein.

CBLC LYN

9.81e-06445210362357
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF1 PRAMEF13 PRAMEF14

1.29e-053545319389355
Pubmed

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

VANGL2 PKD1

1.63e-05545226245976
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF1 PRAMEF13 PRAMEF14

2.96e-054645317287250
Pubmed

c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination.

CBLC LYN

3.42e-05745212244174
Pubmed

Polycystic Kidney Disease, Autosomal Dominant

ALG9 PKD1

3.42e-05745220301424
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF1 PRAMEF13 PRAMEF14

3.80e-055045331806660
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF1 PRAMEF13 CPEB1

5.94e-055845331598710
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CBLC SIRT2 EFNA2 SHANK2 CABIN1 PI4KA FAM83H PKD1

7.68e-05110545835748872
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

PRAMEF1 PRAMEF13 PI4KA PRAMEF14 FAM83H PKD1

8.43e-0556445621565611
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

PRAMEF1 PRPF8 PRAMEF13 PRAMEF14 CPEB1

8.46e-0534745516033648
Pubmed

Loss-of-function mutations in FREM2 disrupt eye morphogenesis.

CBLC ECM2

8.94e-051145230802441
Pubmed

Cardiac deletion of Smyd2 is dispensable for mouse heart development.

HELZ SMYD2

1.27e-041345220305823
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH17 DNAH1

1.47e-04144529373155
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF1 PRAMEF13

2.20e-041745223565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF1 PRAMEF13

2.20e-041745237781892
Pubmed

O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.

CABIN1 MAP3K7

2.20e-041745227217568
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

NAP1L2 PRAMEF1 PRAMEF13 PRAMEF14 HHAT CEMIP

2.22e-0467445637196079
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF1 PRAMEF13

2.47e-041845239181896
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

VANGL2 PRAMEF1 PRAMEF14 MANEAL HHAT SMYD2 TMEM59

3.35e-04103145716710414
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

VANGL2 POGLUT3 SIRT2 UFSP2 ALG9

3.39e-0446845531056421
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

PRDM13 ACVR1B PRPF8 LYN PI4KA PKD1

3.55e-0473645629676528
Pubmed

The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.

LYN MAP3K7

3.72e-042245211356033
Pubmed

Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.

VANGL2 PKD1

3.72e-042245227582005
Pubmed

Maternal microRNAs are essential for mouse zygotic development.

PRAMEF1 PRAMEF13 PRAMEF14 CPEB1

4.30e-0427345417369397
Pubmed

Primary Ciliary Dyskinesia

HYDIN DNAH1

7.92e-043245220301301
Pubmed

Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.

SIRT2 HYDIN

9.48e-043545237890489
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

SIRT2 PRAMEF1 PRAMEF13 PRAMEF14 MANEAL SMYD2 DNAH17

1.01e-03124245730973865
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NAP1L2 PRPF8 CABIN1 SMYD2 TMEM59 ME3 PKD1

1.23e-03128545735914814
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF1 CABIN1 PRAMEF13 PRAMEF14

1.24e-0336345414691545
Cytoband1p36.21

PRAMEF1 PRAMEF13 PRAMEF14

3.35e-05634531p36.21
GeneFamilyMannosidases endo-alpha

MANEA MANEAL

2.85e-0623121195
GeneFamilyPRAME family

PRAMEF1 PRAMEF13 PRAMEF14

9.02e-0624313686
GeneFamilyDyneins, axonemal

DNAH17 DNAH1

3.81e-0417312536
DiseasePolycystic Kidney, Autosomal Dominant

ALG9 PKD1

6.74e-059412C0085413
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

CDC25A PKD1

2.23e-0416412DOID:0110861 (implicated_via_orthology)
Diseasetotal blood protein measurement

CACNA2D1 ZNF609 HYDIN DNAH1 PKD1

3.81e-04449415EFO_0004536
Diseasecortical thickness

VANGL2 IL34 MAP3K7 PI4KA HHAT CPEB1 PKD1

7.80e-041113417EFO_0004840
DiseasePolynesian Bronchiectasis

HYDIN DNAH1

1.09e-0335412C4317124
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

HYDIN DNAH1

1.09e-0335412C4551906
DiseaseKartagener Syndrome

HYDIN DNAH1

1.09e-0335412C0022521
DiseasePrimary ciliary dyskinesia

HYDIN DNAH1

1.15e-0336412cv:C0008780

Protein segments in the cluster

PeptideGeneStartEntry
LEKYYHDFPVYNPAL

VANGL2

276

Q9ULK5
LAKLGYDPYANPPNY

TPST1

321

O60507
FYLYPDGKTHNPDLT

CBLC

306

Q9ULV8
GVHEEYQLPYYDLVP

ACVR1B

421

P36896
YHGPLDLYPEFYRIA

ALG9

436

Q9H6U8
PYYLDLSDHKYLLEG

C14orf28

241

Q4W4Y0
YSPGYSEHIPLGKFY

CEMIP

711

Q8WUJ3
KLAYYDPHPYRGTAI

NAP1L2

311

Q9ULW6
SLYNVLHGAEPLPYY

MAP3K7

111

O43318
HKDQPYYDIPDAPYR

PI4KA

1026

P42356
ALFPPDLVILHDYYY

PNPLA1

231

Q8N8W4
KYSHLPYNKYSVLLP

NUDT7

31

P0C024
YIKDYLHPYVEAGNP

HELZ

706

P42694
NTVYLDYRPHKPGLY

MANEA

421

Q5SRI9
AYVFYYPVLHNGPIL

HHAT

206

Q5VTY9
QIPPTYDLHGYLSYI

DNAH1

3921

Q9P2D7
YDLHGYLSYIKSLPL

DNAH1

3926

Q9P2D7
HYFPINYKISVPYEG

IL34

56

Q6ZMJ4
PEAEYGLHLYFQPTK

HYDIN

2991

Q4G0P3
PPVVNELYYLLADYH

CABIN1

1051

Q9Y6J0
FQIPPNLDYKGYHEY

DNAH17

4126

Q9UFH2
YYFAIDPNGYVLLHP

CACNA2D1

511

P54289
DLSYNKLYHVPSYLP

ECM2

541

O94769
YLDYLPHQPSLYLEL

MANEAL

426

Q5VSG8
LYPYDGIHPDDLSFK

LYN

71

P07948
AYKHNLASYYPEPKD

ME3

556

Q16798
NDYLDIYCPHYGAPL

EFNA2

66

O43921
HDPLSPDGLSEYYFK

CPEB1

381

Q9BZB8
PPHYKEYYRLAVDAL

FAM83H

21

Q6ZRV2
YGSPATTAYYPLKLH

PRDM13

471

Q9H4Q3
LGNEYPKLHYPELYV

CDC25A

451

P30304
YPSLGYLKHLNLSYV

PRAMEF13

316

Q5VWM6
GHYLSEEPEPYLAVY

PKD1

2931

P98161
YSHLISYFPEYTGPK

GNA14

281

O95837
LLLYRKGPPFYHASY

TSEN2

366

Q8NCE0
LADLFYLPYEHGPKG

OGA

561

O60502
YPSLGYLKHLNLSYV

PRAMEF14

316

Q5SWL7
TGLYDNLEKYHLPYP

SIRT2

101

Q8IXJ6
YPSLGYLKHLNLSYV

PRAMEF1

316

O95521
SPDYKDSYGLTPLYH

SHANK2

256

Q9UPX8
YKDGYIRNPHTYLNP

UFSP2

256

Q9NUQ7
EYKIAFPYLYNNLPH

PRPF8

311

Q6P2Q9
AQSPYILKGPVYHEY

POGLUT3

126

Q7Z4H8
YPLHTYPKEEELYAC

TMEM59

56

Q9BXS4
HLGYSLLPAQYNLPY

ZNF609

1371

O15014
YHYSGFPDLYEPILE

USP38

386

Q8NB14
IIKPYSKHYPLYSLN

SMYD2

366

Q9NRG4