Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	RAD51B ABCA1 SMARCA5 ERCC2 ERCC6 KIF1A TOR4A FBH1 ATP11B RECQL4 ABCC12 DHX29 KIFC1	5.75e-06	441	129	13	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	RAD51B ABCA1 SMARCA5 ERCC2 ERCC6 MYO1A KIF1A TOR4A FBH1 ATP11B RECQL4 ACSF3 ABCC12 DHX29 KIFC1	1.03e-05	614	129	15	GO:0140657
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RAD51B SMARCA5 ERCC2 ERCC6 FBH1 RECQL4	1.77e-04	127	129	6	GO:0008094
GeneOntologyMolecularFunction	pyrophosphatase activity	RAD51B ABCA1 SMARCA5 ERCC2 ERCC6 KIF1A TOR4A GTPBP2 FBH1 ATP11B RECQL4 ABCC12 PGP DHX29 KIFC1	3.43e-04	839	129	15	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RAD51B ABCA1 SMARCA5 ERCC2 ERCC6 KIF1A TOR4A GTPBP2 FBH1 ATP11B RECQL4 ABCC12 PGP DHX29 KIFC1	3.47e-04	840	129	15	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RAD51B ABCA1 SMARCA5 ERCC2 ERCC6 KIF1A TOR4A GTPBP2 FBH1 ATP11B RECQL4 ABCC12 PGP DHX29 KIFC1	3.47e-04	840	129	15	GO:0016818
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE3 SYNE2	4.09e-04	5	129	2	GO:0140444
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RAD51B ABCA1 SMARCA5 ERCC2 ERCC6 KIF1A TOR4A GTPBP2 FBH1 ATP11B RECQL4 ABCC12 DHX29 KIFC1	4.92e-04	775	129	14	GO:0017111
GeneOntologyMolecularFunction	helicase activity	SMARCA5 ERCC2 ERCC6 FBH1 RECQL4 DHX29	5.70e-04	158	129	6	GO:0004386
GeneOntologyMolecularFunction	DNA helicase activity	ERCC2 ERCC6 FBH1 RECQL4	6.94e-04	62	129	4	GO:0003678
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	RAD51B SMARCA5 ERCC2 ERCC6 DIS3L QTRT2 EXOSC2 TARS3 FBH1 RECQL4 DHX29 MUTYH	9.76e-04	645	129	12	GO:0140640
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	ARHGEF28 KRT31 KRT33A KRT27 KRT33B KRT28 GFAP DST	2.25e-07	99	131	8	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	ARHGEF28 KRT31 KRT33A KRT27 KRT33B KRT28 GFAP DST	2.43e-07	100	131	8	GO:0045103
GeneOntologyBiologicalProcess	intermediate filament organization	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP	8.23e-06	75	131	6	GO:0045109
GeneOntologyBiologicalProcess	double-strand break repair via homologous recombination	RAD51B ERCC6 TRRAP CREBBP RFWD3 FBH1 RECQL4 RAD21	2.73e-05	188	131	8	GO:0000724
GeneOntologyBiologicalProcess	recombinational repair	RAD51B ERCC6 TRRAP CREBBP RFWD3 FBH1 RECQL4 RAD21	3.42e-05	194	131	8	GO:0000725
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase I	SMARCA5 CREBBP DEDD	3.98e-05	11	131	3	GO:0016479
GeneOntologyBiologicalProcess	double-strand break repair	RAD51B ATP23 ERCC6 TRRAP CREBBP RFWD3 FBH1 RECQL4 UVRAG RAD21	4.29e-05	324	131	10	GO:0006302
GeneOntologyBiologicalProcess	DNA repair	RAD51B SMARCA5 ERCC2 ATP23 ERCC6 TRRAP CREBBP RFWD3 FBH1 RECQL4 UVRAG MUTYH USP47 RAD21	6.59e-05	648	131	14	GO:0006281
GeneOntologyBiologicalProcess	regulation of cell cycle process	RAD51B TPR SMARCA5 ERCC2 ERCC6 CTC1 TRRAP CREBBP RFWD3 TELO2 RECQL4 CEP131 FGFR1 UVRAG USP47 RAD21	9.25e-05	845	131	16	GO:0010564
GeneOntologyBiologicalProcess	DNA damage response	RAD51B SMARCA5 ERCC2 ATP23 ERCC6 CTC1 IKBKG TRRAP CREBBP RFWD3 FBH1 TELO2 RECQL4 UVRAG MUTYH USP47 RAD21	1.23e-04	959	131	17	GO:0006974
GeneOntologyBiologicalProcess	transcription by RNA polymerase I	SMARCA5 ERCC2 ERCC6 CREBBP DEDD	1.48e-04	79	131	5	GO:0006360
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	TPR APC2 CCDC88B KIAA1614 CCDC39 DST AKAP9 SYNE2 PDE4DIP CEP131 LZTS2 CROCC UVRAG KIFC1	1.98e-04	720	131	14	GO:0000226
GeneOntologyCellularComponent	subapical part of cell	AKAP9 CROCC	1.18e-04	3	132	2	GO:0120219
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP DST SYNE2	2.71e-04	263	132	8	GO:0045111
GeneOntologyCellularComponent	ubiquitin ligase complex	ZSWIM8 FBXL13 IKBKG RNF40 ASB12 FBH1 FBXL18 ZER1 USP47	4.06e-04	352	132	9	GO:0000151
GeneOntologyCellularComponent	intracellular protein-containing complex	ZSWIM8 ERCC2 FBXL13 ATP23 APC2 IKBKG RNF40 ASB12 TRRAP MBIP CREBBP FBH1 FBXL18 ZER1 CARD11 USP47	4.22e-04	972	132	16	GO:0140535
GeneOntologyCellularComponent	intermediate filament	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP DST	6.07e-04	227	132	7	GO:0005882
Domain	Keratin_I	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP	6.02e-07	44	131	6	IPR002957
Domain	Filament	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP	1.05e-05	71	131	6	SM01391
Domain	IF	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP	1.13e-05	72	131	6	PS00226
Domain	Filament	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP	1.23e-05	73	131	6	PF00038
Domain	IF	KRT31 KRT33A KRT27 KRT33B KRT28 GFAP	1.55e-05	76	131	6	IPR001664
Domain	DNA/RNA_helicase_DEAH_CS	SMARCA5 ERCC2 RECQL4 DHX29	1.02e-04	35	131	4	IPR002464
Domain	DEAH_ATP_HELICASE	SMARCA5 ERCC2 RECQL4 DHX29	1.42e-04	38	131	4	PS00690
Domain	KASH	SYNE3 SYNE2	2.90e-04	4	131	2	IPR012315
Domain	KASH	SYNE3 SYNE2	2.90e-04	4	131	2	PS51049
Domain	KASH	SYNE3 SYNE2	2.90e-04	4	131	2	SM01249
Domain	KASH	SYNE3 SYNE2	2.90e-04	4	131	2	PF10541
Domain	Spectrin	SYNE3 DST SYNE2	5.39e-04	23	131	3	PF00435
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ERCC2 CTC1 NLRX1 INTS1 TOR4A RNF40 RALGAPA2 TRRAP CDC42BPB SLC1A5 MPRIP THADA SYNE3 DST KANK3 TMEM268 ZER1 CEP131 FGFR1 PREX1 UVRAG WNK2 RASAL1 PICK1	5.38e-12	1105	133	24	35748872
Pubmed	The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.	KRT33A KRT27 KRT33B KRT28	9.88e-08	12	133	4	15617563
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TPR ANKFY1 APC2 CDC42BPB MPRIP LRIG2 TXLNA DST AKAP9 SYNE2 PDE4DIP KCNMA1 AFDN CEP131 WNK2 GOLGB1 RASAL1	1.75e-07	963	133	17	28671696
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TPR ANKFY1 GEMIN2 IKBKG RNF40 RBBP8NL MBIP GREB1L DST CEP131 GOLGB1	6.74e-07	418	133	11	34709266
Pubmed	Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation.	KRT31 KRT33A KRT33B	1.08e-06	6	133	3	10559501
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ERCC2 ERCC6 KIF1A GEMIN2 INTS1 TRRAP CDC42BPB EXOSC2 MPRIP GREB1L DST AFDN CEP131 LZTS2 CROCC DHX29 PREX1 GOLGB1 KIFC1 RAD21	1.11e-06	1497	133	20	31527615
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	TPR DPY19L2 RNF40 SLC1A5 RFWD3 TXLNA EIF2B1 CEP131 GOLGB1	1.65e-06	285	133	9	32838362
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZSWIM8 OXR1 KIF1A DIS3L APC2 RNF40 CDC42BPB CREBBP GFAP MPRIP TARS3 DST FBH1 PDE4DIP AFDN PREX1 PICK1 USP47	2.09e-06	1285	133	18	35914814
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ERCC2 ANKFY1 NLRX1 INTS1 IKBKG TRRAP CREBBP MPRIP TXLNA DST AKAP9 EIF2B1 PDE4DIP FGFR1 LZTS2	2.27e-06	910	133	15	36736316
Pubmed	New consensus nomenclature for mammalian keratins.	KRT31 KRT33A KRT27 KRT33B KRT28	4.46e-06	63	133	5	16831889
Pubmed	Characterization of a 190-kilobase pair domain of human type I hair keratin genes.	KRT31 KRT33A KRT33B	4.52e-06	9	133	3	9756910
Pubmed	Human hair keratins.	KRT31 KRT33A KRT33B	4.52e-06	9	133	3	7686952
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	PPFIA2 RNF40 DST PDE4DIP PREX1 GOLGB1	4.55e-06	111	133	6	22558309
Pubmed	The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.	KRT31 KRT33A KRT33B	6.43e-06	10	133	3	10391933
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPR ZSWIM8 SMARCA5 IPO7 KIF1A INTS1 TRRAP DST SYNE2 AFDN USP47 RAD21	8.44e-06	653	133	12	22586326
Pubmed	Defining the membrane proteome of NK cells.	ABHD15 IPO7 CYP51A1 INTS1 RNF40 CCDC88B SLC1A5 TXLNA SYNE3 ATP11B APH1A RECQL4 COG5 GOLGB1 KIFC1 RAD21	1.06e-05	1168	133	16	19946888
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	TRRAP GFAP AKAP9 GOLGB1 USP47	1.13e-05	76	133	5	27542412
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ZSWIM8 ARHGEF28 MBIP GREB1L THADA FBH1 CEP131 FGFR1 DHX29 UVRAG MUTYH GP1BA FILIP1L TEDC1	1.32e-05	925	133	14	28986522
Pubmed	Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells.	ABCA1 TXLNA	1.45e-05	2	133	2	26494466
Pubmed	The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer.	ERCC2 ERCC6	1.45e-05	2	133	2	26649138
Pubmed	Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.	LRRC55 KCNMA1	1.45e-05	2	133	2	33346797
Pubmed	Differential expression of type I hair keratins.	KRT33A KRT33B	1.45e-05	2	133	2	1689759
Pubmed	Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling.	CYP51A1 RORC	1.45e-05	2	133	2	28098217
Pubmed	Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons.	SYNE3 DST	1.45e-05	2	133	2	18638474
Pubmed	A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms.	KRT33A KRT33B	1.45e-05	2	133	2	7565656
Pubmed	The Involvement of ERCC2/XPD and ERCC6/CSB Wild Type Alleles in Protection Against Aging and Cancer.	ERCC2 ERCC6	1.45e-05	2	133	2	28707579
Pubmed	CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.	CREBBP RAD21	1.45e-05	2	133	2	38066319
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IPO7 CYP51A1 CDC42BPB SLC1A5 MPRIP LRIG2 TXLNA THADA SYNE3 AKAP9 TELO2 SYNE2 LRRC1 CEP131 LZTS2 DHX29 GOLGB1 RAD21	1.54e-05	1487	133	18	33957083
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	SMARCA5 APC2 TRRAP	2.41e-05	15	133	3	16510875
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	GEMIN2 KRT31 KRT33A KRT33B CASP4 TRRAP CDC42BPB SLC1A5 MPRIP TXLNA TELO2 EIF2B1 AFDN MTX1 DEDD PREX1	3.36e-05	1284	133	16	17353931
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	IPO7 KIF1A CDC42BPB SLC1A5 TELO2 RAD21	3.66e-05	160	133	6	31678930
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TPR SMARCA5 IPO7 GEMIN2 KRT33B INTS1 TRRAP SLC1A5 DST SYNE2 AFDN CEP131 GOLGB1 KIFC1	4.01e-05	1024	133	14	24711643
Pubmed	XPD, APE1, and MUTYH polymorphisms increase head and neck cancer risk: effect of gene-gene and gene-environment interactions.	ERCC2 MUTYH	4.34e-05	3	133	2	25916209
Pubmed	The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.	SYNE3 SYNE2	4.34e-05	3	133	2	23336069
Pubmed	Molecular Pathway of Microtubule Organization at the Golgi Apparatus.	AKAP9 PDE4DIP	4.34e-05	3	133	2	27666745
Pubmed	Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation.	CASP4 CARD11	4.34e-05	3	133	2	32401674
Pubmed	MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study.	ERCC2 MUTYH	4.34e-05	3	133	2	20571908
Pubmed	Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation.	CREBBP FGFR1	4.34e-05	3	133	2	15929978
Pubmed	DNA-repair gene variants are associated with glioblastoma survival.	RAD51B RECQL4	4.34e-05	3	133	2	22017238
Pubmed	An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.	ERCC2 ERCC6	4.34e-05	3	133	2	16904611
Pubmed	The RAIG family member, GPRC5D, is associated with hard-keratinized structures.	KRT33A KRT33B	4.34e-05	3	133	2	15086536
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAD51B KIF1A PPFIA2 RBBP8NL TRRAP CDC42BPB CREBBP THADA ATP11B SIGIRR LRRC1 KCNMA1 ACSF3 LZTS2 CROCC WNK2 GOLGB1	5.60e-05	1489	133	17	28611215
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ZSWIM8 PPFIA2 APC2 CYP51A1 CCDC88B MBIP GFAP MPRIP LZTS2 PICK1	6.22e-05	560	133	10	21653829
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TPR SMARCA5 ANKFY1 ERCC6 IPO7 TOR4A TRRAP CREBBP SLC1A5 MPRIP DST FBXL18 RECQL4 AFDN PGP DHX29	6.25e-05	1353	133	16	29467282
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	FBXL13 IPO7 GEMIN2 KRT33A KRT33B RALGAPA2 GFAP VPS13D KCNMA1 GOLGB1	6.60e-05	564	133	10	21565611
Pubmed	Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control.	CREBBP FGFR1	8.67e-05	4	133	2	19261810
Pubmed	Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.	ERCC2 ERCC6	8.67e-05	4	133	2	10416615
Pubmed	High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk.	ERCC2 ERCC6	8.67e-05	4	133	2	17728339
Pubmed	KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles.	KIF1A KIFC1	8.67e-05	4	133	2	9115736
Pubmed	Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists.	ERCC2 ERCC6	8.67e-05	4	133	2	18767034
Pubmed	Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.	KRT27 KRT28	8.67e-05	4	133	2	17920809
Pubmed	p53 modulation of TFIIH-associated nucleotide excision repair activity.	ERCC2 ERCC6	8.67e-05	4	133	2	7663514
Pubmed	Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.	TRRAP CREBBP	8.67e-05	4	133	2	18347063
Pubmed	Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.	ERCC2 ERCC6	8.67e-05	4	133	2	10843671
Pubmed	[The polymorphism of DNA repair genes XPD, XRCC1, OGG1, and ERCC6, life expectancy, and the inclination to smoke].	ERCC2 ERCC6	8.67e-05	4	133	2	25731027
Pubmed	Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.	ERCC2 ERCC6	8.67e-05	4	133	2	16472827
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	TPR MPRIP TXLNA CEP131 GOLGB1	9.39e-05	118	133	5	30979931
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	FBXL13 RNF40 ALPK1 RFWD3 FBH1 FBXL18 FGFR1 PRKG2	9.75e-05	372	133	8	22939624
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	CTC1 TXLNA FBH1 ZER1 AFDN	1.02e-04	120	133	5	27565346
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	RNF40 DST AKAP9 PDE4DIP PICK1	1.02e-04	120	133	5	31413325
Pubmed	Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.	SMARCA5 CREBBP GFAP	1.04e-04	24	133	3	24946904
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	GEMIN2 RALGAPA2 TRRAP CDC42BPB EXOSC2 MRPS30 THADA ATP11B TELO2 EIF2B1 AFDN	1.05e-04	719	133	11	35337019
Pubmed	A human MAP kinase interactome.	TPR CCDC88B CDC42BPB CREBBP GFAP DST COG5 WNK2 GOLGB1	1.11e-04	486	133	9	20936779
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARHGEF28 ALPK1 SLC1A5 MPRIP VPS13D DST AKAP9 SYNE2 AFDN CEP131 UVRAG GOLGB1	1.22e-04	861	133	12	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGEF28 DIS3L ALPK1 RALGAPA2 CDC42BPB LRIG2 VPS13D THADA PREX1	1.24e-04	493	133	9	15368895
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	TPR SMARCA5 IPO7 KRT31 INTS1 CDC42BPB DST SYNE2 DHX29	1.34e-04	498	133	9	36634849
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	TRIM15 KRT31 KRT33B RNF40 MBIP GFAP PDE4DIP FGFR1 LZTS2 COG5 MUTYH	1.39e-04	742	133	11	26871637
Pubmed	PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.	IKBKG CARD11	1.44e-04	5	133	2	16301747
Pubmed	Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.	ERCC2 ERCC6	1.44e-04	5	133	2	22174697
Pubmed	Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.	LRRC55 KCNMA1	1.44e-04	5	133	2	26009545
Pubmed	BK potassium channel modulation by leucine-rich repeat-containing proteins.	LRRC55 KCNMA1	1.44e-04	5	133	2	22547800
Pubmed	Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE.	TRPA1 KCNMA1	1.44e-04	5	133	2	28498403
Pubmed	Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.	IKBKG CARD11	1.44e-04	5	133	2	25606824
Pubmed	NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex.	NLRX1 UVRAG	1.44e-04	5	133	2	30488027
Pubmed	Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study.	ERCC2 ERCC6	1.44e-04	5	133	2	16258177
Pubmed	Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology.	ARHGEF28 MPRIP	1.44e-04	5	133	2	9199174
Pubmed	Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex.	IKBKG CARD11	1.44e-04	5	133	2	23690623
Pubmed	[Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers].	ERCC2 ERCC6	1.44e-04	5	133	2	17313739
Pubmed	Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression.	IKBKG CREBBP	1.44e-04	5	133	2	14597638
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE3 SYNE2	1.44e-04	5	133	2	18396275
Pubmed	Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer.	ERCC2 ERCC6	1.44e-04	5	133	2	15746040
Pubmed	Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.	SLC1A5 CARD11	1.44e-04	5	133	2	24792914
Pubmed	Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers.	ERCC2 ERCC6	1.44e-04	5	133	2	17438655
Pubmed	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.	IKBKG PDE4DIP GOLGB1	1.50e-04	27	133	3	18685082
Pubmed	Variation within DNA repair pathway genes and risk of multiple sclerosis.	RAD51B ERCC2 ERCC6 MUTYH	1.72e-04	72	133	4	20522537
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ZSWIM8 ERCC2 GEMIN2 DIS3L ALPK1 RFWD3 TELO2 EIF2B1 KCTD20 LZTS2 UVRAG USP47 TEDC1	1.82e-04	1038	133	13	26673895
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RNF40 KIAA1614 ST6GAL2 DST ATP11B TELO2 LZTS2 WNK2 RAD21	2.09e-04	529	133	9	14621295
Pubmed	CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.	CREBBP GFAP	2.16e-04	6	133	2	20152182
Pubmed	Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis.	GFAP FGFR1	2.16e-04	6	133	2	18329286
Pubmed	Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.	IKBKG CARD11	2.16e-04	6	133	2	19706536
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE3 SYNE2	2.16e-04	6	133	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE3 SYNE2	2.16e-04	6	133	2	18827015
Pubmed	The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.	SMARCA5 RNF40	2.16e-04	6	133	2	37155876
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	GFAP WNK2	2.16e-04	6	133	2	21733846
Pubmed	Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization.	CASP4 CARD11	2.16e-04	6	133	2	17293856
Pubmed	Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain.	GFAP FGFR1	2.16e-04	6	133	2	29132503
Pubmed	Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.	ERCC2 ERCC6	2.16e-04	6	133	2	23562818
Pubmed	Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.	ERCC2 ERCC6	2.16e-04	6	133	2	16399771
Pubmed	Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.	IKBKG CARD11	2.16e-04	6	133	2	27777308
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	ERCC2 ERCC6 RECQL4	2.27e-04	31	133	3	32355176
Interaction	KRT8 interactions	KRT31 KRT33A KRT27 KRT33B KRT28 IKBKG PPEF2 ASB12 GFAP THADA AKAP9 ZER1 CEP131 LZTS2 DEDD	1.88e-07	441	131	15	int:KRT8
Interaction	COMTD1 interactions	IPO7 GEMIN2 NLRX1 INTS1 LRIG2 TARS3 THADA EIF2B1 LRRC1 COG5	7.53e-07	200	131	10	int:COMTD1
Interaction	INA interactions	ANKFY1 KRT31 KRT27 TRRAP GFAP MIDN SYNE3 RECQL4 KCNMA1	1.98e-06	173	131	9	int:INA
Interaction	CEP152 interactions	ANKFY1 FBXL13 KIF1A GFAP TXLNA SYNE3 AFDN CEP131 LZTS2	2.63e-06	179	131	9	int:CEP152
Interaction	EFNA4 interactions	KRT31 KRT33B INTS1 NR6A1 GFAP THADA PDE4DIP COG5 MTX1 TEDC1	3.75e-06	239	131	10	int:EFNA4
Interaction	MOS interactions	KRT31 KRT27 KRT33B GFAP LZTS2 PICK1	1.18e-05	78	131	6	int:MOS
Interaction	EXOSC5 interactions	KRT31 DIS3L KRT27 CCDC88B EXOSC2 RECQL4 LZTS2 PICK1	1.20e-05	164	131	8	int:EXOSC5
Interaction	CCDC146 interactions	KRT31 KRT27 RNF40 TXLNA AKAP9 PDE4DIP	1.57e-05	82	131	6	int:CCDC146
Interaction	TOP3B interactions	ERCC2 CTC1 NLRX1 INTS1 TOR4A RNF40 RALGAPA2 TRRAP CDC42BPB SLC1A5 MPRIP THADA SYNE3 DST KANK3 TMEM268 ZER1 CEP131 FGFR1 PREX1 UVRAG WNK2 RASAL1 PICK1	2.40e-05	1470	131	24	int:TOP3B
Interaction	RTP5 interactions	KRT31 KRT27 KRT33B PDE4DIP LZTS2	2.40e-05	53	131	5	int:RTP5
Interaction	USP2 interactions	KRT31 KRT27 KRT33B IKBKG CCDC88B RECQL4 CARD11 LZTS2 PICK1	2.69e-05	239	131	9	int:USP2
Interaction	SIPA1L2 interactions	ANKFY1 ICE2 RALGAPA2 GFAP SYNE3 AFDN LZTS2	3.04e-05	136	131	7	int:SIPA1L2
Interaction	NEFM interactions	KRT31 KRT27 IKBKG GFAP CCDC39 MIDN KCNMA1 ABCC12	3.47e-05	190	131	8	int:NEFM
Interaction	CTSG interactions	KRT31 ICE2 FGFR1 PICK1 GP1BA RAD21	3.64e-05	95	131	6	int:CTSG
Interaction	PPP1R18 interactions	KRT31 KRT27 KRT33B CCDC88B GFAP PDE4DIP LZTS2	3.83e-05	141	131	7	int:PPP1R18
Interaction	KDM1A interactions	TPR SMARCA5 ANKFY1 GEMIN2 KRT31 KRT33B IKBKG RNF40 RBBP8NL TRRAP GREB1L GTPBP2 DST AKAP9 RECQL4 PDE4DIP CEP131 GOLGB1	3.85e-05	941	131	18	int:KDM1A
Interaction	KRT72 interactions	KRT31 KRT27 KRT33B KRT28 TRRAP	4.06e-05	59	131	5	int:KRT72
Interaction	BRCA2 interactions	RAD51B ERCC2 FBXL13 ERCC6 TRRAP GREB1L SYNE3 FBH1 CEP131 LZTS2 RAD21	4.29e-05	384	131	11	int:BRCA2
Interaction	DSCR9 interactions	KIF1A DIS3L DST FBH1 PDE4DIP PICK1 USP47	5.00e-05	147	131	7	int:DSCR9
Interaction	DTNB interactions	KRT31 KRT27 KRT33B CCDC88B TXLNA PICK1	5.14e-05	101	131	6	int:DTNB
Interaction	CCDC198 interactions	FBXL13 KRT31 PDE4DIP LZTS2	7.64e-05	35	131	4	int:CCDC198
Interaction	PHF21A interactions	TPR ANKFY1 GEMIN2 KRT27 IKBKG RNF40 MBIP DST CEP131 GOLGB1	8.35e-05	343	131	10	int:PHF21A
Interaction	KRT82 interactions	KRT31 KRT27 KRT33B RNF40	9.54e-05	37	131	4	int:KRT82
Interaction	HDAC1 interactions	TPR SMARCA5 ANKFY1 ERCC6 GEMIN2 IKBKG RNF40 MBIP CREBBP DST AKAP9 SYNE2 RECQL4 RORC CEP131 CROCC GOLGB1 USP47 RAD21	9.98e-05	1108	131	19	int:HDAC1
Interaction	SIPA1L3 interactions	ICE2 RALGAPA2 GFAP SYNE3 AFDN LZTS2	1.22e-04	118	131	6	int:SIPA1L3
Interaction	PFN1 interactions	TPR TRIM15 ANKFY1 ASB12 MPRIP THADA AKAP9 SYNE2 RECQL4 AFDN CEP131 GOLGB1	1.24e-04	509	131	12	int:PFN1
Interaction	WHAMMP3 interactions	IKBKG RNF40 MPRIP AKAP9 CEP131 CROCC	1.28e-04	119	131	6	int:WHAMMP3
Interaction	DSCAM interactions	APC2 GFAP MPRIP TARS3 DST PDE4DIP AFDN	1.29e-04	171	131	7	int:DSCAM
Interaction	TSC1 interactions	KRT27 PPFIA2 CCDC88B MBIP GFAP SYNE3 LZTS2 WNK2 RASAL1 PICK1	1.42e-04	366	131	10	int:TSC1
Interaction	CEP63 interactions	KRT31 MBIP TXLNA SYNE3 DST CEP131 LZTS2	1.72e-04	179	131	7	int:CEP63
Interaction	KRT71 interactions	KRT31 KRT27 KRT33B KRT28	1.73e-04	43	131	4	int:KRT71
Interaction	ATOH1 interactions	TRRAP GFAP AKAP9 GOLGB1 USP47	1.75e-04	80	131	5	int:ATOH1
Interaction	EIF4E2 interactions	KRT31 DIS3L EXOSC2 TARS3 SYNE3 RECQL4 AFDN LZTS2	2.09e-04	246	131	8	int:EIF4E2
GeneFamily	Keratins, type I	KRT31 KRT33A KRT27 KRT33B KRT28	1.95e-07	28	86	5	608
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE3 SYNE2	1.33e-04	4	86	2	1252
GeneFamily	WD repeat domain containing\|ERCC excision repair associated	ERCC2 ERCC6	4.62e-04	7	86	2	1268
GeneFamily	Ankyrin repeat domain containing	ANKFY1 TRPA1 ASB12 KANK3 ANKRD61 NOTCH4	1.04e-03	242	86	6	403
GeneFamily	Exosome complex	DIS3L EXOSC2	1.43e-03	12	86	2	817
GeneFamily	DNA helicases	ERCC2 FBH1	2.90e-03	17	86	2	1167
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	KIF1A MPRIP TARS3 VPS13D DST GOLGB1 USP47	1.06e-06	177	133	7	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	wk_15-18-Epithelial-PNS-KCNIP4+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CACNA1B ARHGEF28 KIF1A APC2 LRRC55 ST6GAL2 OLFM3	1.14e-06	179	133	7	e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	WWC3 PCDH12 RALGAPA2 KANK3 SYNE2 PREX1 NOTCH4	2.09e-06	196	133	7	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR6A1 THADA LRRC1 RORC CROCC WNK2	1.54e-05	177	133	6	291231b1520c135e92739e201495fe1935efa927
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KIF1A CTC1 GFAP KIAA1614 GTPBP2 PRKG2	1.59e-05	178	133	6	a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCell	droplet-Lung-nan-21m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAD51B ARHGEF28 KIF1A PPEF2 RORC INAVA	1.65e-05	179	133	6	d78eacf47847a50888dd16c35bed9b7afc80010f
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRIM15 NR6A1 SLC1A5 SYNE3 ATP11B ZER1	2.04e-05	186	133	6	e5014443e9d6e25943308483e20d48b776ae5373
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRIM15 NR6A1 SLC1A5 SYNE3 ATP11B ZER1	2.04e-05	186	133	6	affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCell	LPS_only-Hematopoietic_Meg-Ery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRIM15 NR6A1 SLC1A5 SYNE3 ATP11B ZER1	2.04e-05	186	133	6	40d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR SMARCA5 CREBBP AKAP9 SYNE2 GOLGB1	2.11e-05	187	133	6	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPRIP DST AKAP9 AFDN GOLGB1 FILIP1L	2.30e-05	190	133	6	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF28 CNTNAP3 PCDH12 LRRC55 KANK3 NOTCH4	2.37e-05	191	133	6	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DPY19L2 KIF1A PPEF2 GFAP OLFM3 WNK2	2.82e-05	197	133	6	8f009a15f154b3bb184b489da4722b7c27de7e11
ToppCell	10x3'2.3-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF28 CNTNAP3 PCDH12 KANK3 AFDN NOTCH4	2.90e-05	198	133	6	2630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell	10x5'v1-week_12-13-Endothelial-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF28 CNTNAP3 PCDH12 KANK3 FGFR1 NOTCH4	2.90e-05	198	133	6	122215d9288533ad03562cf777e846504863df9a
ToppCell	10x5'v1-week_12-13-Endothelial\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF28 CNTNAP3 PCDH12 KANK3 FGFR1 NOTCH4	2.90e-05	198	133	6	307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF28 CNTNAP3 PCDH12 KANK3 AFDN NOTCH4	2.90e-05	198	133	6	1e83bec16dcd60460422625f89952ff506d6be51
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	CACNA1B PPFIA2 AKAP9 C11orf96 PDE4DIP AFDN	2.99e-05	199	133	6	77b4aa00f14b86ef5db0490be98787e063979541
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PCDH12 RALGAPA2 DST SYNE2 AFDN NOTCH4	3.07e-05	200	133	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARHGEF28 DST AKAP9 SYNE2 AFDN GOLGB1	3.07e-05	200	133	6	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGEF28 DST AKAP9 SYNE2 AFDN GOLGB1	3.07e-05	200	133	6	ecbe89ff95d046155b984c8c150e0b9e7278f839
Computational	Genes in the cancer module 486.	KIF1A INTS1 RNF40 RALGAPA2 MPRIP DEDD	6.20e-05	100	74	6	MODULE_486
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; MCF7; HT_HG-U133A	TPR ABCA1 ANKFY1 KIF1A CREBBP EXOSC2 GTPBP2 FGFR1 PICK1	2.45e-06	197	133	9	5974_UP
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 1000uM; MCF7; HG-U133A	INTS1 ALPK1 LRRC1 PDE4DIP RORC CEP131 FGFR1 PRKG2 PICK1	2.66e-06	199	133	9	4_DN
Drug	Econazole nitrate [24169-02-6]; Down 200; 9uM; MCF7; HT_HG-U133A	ANKFY1 ALPK1 LRIG2 VPS13D AKAP9 APH1A ZER1 CEP131	1.76e-05	192	133	8	7427_DN
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	ERCC2 ANKFY1 NR6A1 KCTD20 AFDN HEMK1 PICK1 GP1BA	1.97e-05	195	133	8	3843_UP
Drug	Cefadroxil [50370-12-2]; Up 200; 11uM; HL60; HT_HG-U133A	ERCC2 IKBKG EXOSC2 FBXL18 ZER1 HEMK1 FGFR1 PGP	2.04e-05	196	133	8	1323_UP
Drug	Budesonide [51333-22-3]; Down 200; 9.2uM; HL60; HG-U133A	GEMIN2 INTS1 SLC1A5 TXLNA VPS13D THADA TELO2 DHX29	2.04e-05	196	133	8	1716_DN
Drug	celecoxib; Down 200; 10uM; PC3; HG-U133A	RAD51B ALPK1 FBXL18 PDE4DIP HEMK1 RORC PRKG2 CROCC	2.12e-05	197	133	8	482_DN
Drug	Paroxetine maleate [64006-44-6]; Up 200; 1uM; MCF7; HT_HG-U133A	MYO1A NR6A1 ALPK1 CREBBP LRRC1 AFDN RORC GOLGB1	2.20e-05	198	133	8	3904_UP
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	RAD51B ABCA1 ERCC2 PCDH12 VPS13D HOXC5 FBXL18 LRRC1	2.28e-05	199	133	8	4774_UP
Disease	central serous retinopathy	RBBP8NL PREX1 NOTCH4	4.19e-06	8	126	3	EFO_0009784
Disease	Global developmental delay	CACNA1B OXR1 APC2 INTS1 TRRAP GTPBP2	2.37e-05	133	126	6	C0557874
Disease	Adenocarcinoma of large intestine	TRRAP CDC42BPB PRKG2 MUTYH RAD21	5.87e-05	96	126	5	C1319315
Disease	Cerebrooculofacioskeletal Syndrome 1	ERCC2 ERCC6	1.08e-04	4	126	2	C0220722
Disease	stearoyl sphingomyelin (d18:1/18:0) measurement	KANK3 SYNE2	2.68e-04	6	126	2	EFO_0800611
Disease	Cockayne syndrome (implicated_via_orthology)	ERCC2 ERCC6	2.68e-04	6	126	2	DOID:2962 (implicated_via_orthology)
Disease	Large cell carcinoma of lung	TRRAP CDC42BPB FGFR1	3.44e-04	32	126	3	C0345958
Disease	Seizures	CACNA1B OXR1 APC2 TRRAP GFAP GTPBP2	3.58e-04	218	126	6	C0036572
Disease	respiratory system disease	RAD51B CARD11 RORC FGFR1 UVRAG	4.05e-04	145	126	5	EFO_0000684
Disease	Abnormality of the skeletal system	APC2 INTS1	4.98e-04	8	126	2	C4021790
Disease	serum non-albumin protein measurement	FAM178B CDC42BPB GREB1L MIDN AFDN CARD11 TEDC1	9.42e-04	361	126	7	EFO_0004568
Disease	IgG galactosylation measurement	CEP131 TEDC1	1.16e-03	12	126	2	EFO_0008425
Disease	calcium measurement	ICE2 FAM178B NLRX1 SYNE2 ABCC12 FGFR1 MTX1 GOLGB1 TEDC1	1.54e-03	628	126	9	EFO_0004838
Disease	Metabolic Bone Disorder	CTC1 KCNMA1	1.59e-03	14	126	2	C0005944
Disease	IGFBP-3 measurement	CREBBP MPRIP NOTCH4	1.61e-03	54	126	3	EFO_0004626
Disease	Peripheral Nervous System Diseases	CACNA1B ABCA1 GFAP	1.61e-03	54	126	3	C4721453
Disease	Osteopenia	CTC1 KCNMA1	1.83e-03	15	126	2	C0029453
Disease	Squamous cell carcinoma	ERCC2 CREBBP FGFR1 NOTCH4	2.00e-03	124	126	4	C0007137
Disease	sphingomyelin 14:0 measurement	THADA SYNE2	2.36e-03	17	126	2	EFO_0010390
Disease	Microcephaly	ERCC6 PCDH12 TRRAP	2.98e-03	67	126	3	C0025958
Disease	lung non-small cell carcinoma (is_implicated_in)	ERCC2 ERCC6 FGFR1 RAD21	3.03e-03	139	126	4	DOID:3908 (is_implicated_in)
Disease	vitamin D measurement	ABCA1 WIPI1 GEMIN2 RORC FGFR1 COG5	3.27e-03	336	126	6	EFO_0004631
Disease	Infiltrating duct carcinoma of female breast	CDC42BPB FGFR1	3.60e-03	21	126	2	C3165106
Disease	stomach cancer (is_implicated_in)	ERCC2 ERCC6 MUTYH	3.66e-03	72	126	3	DOID:10534 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLLRRCRVNAALTIQ	AFDN	771	P55196
QTRLREIQPCLAESR	RNF40	881	O75150
SRDQVRRCLRANLLV	SLC1A5	41	Q15758
SLRCRELEIIINHNR	AKAP9	991	Q99996
LRSAVNLAERCEQRL	CNTNAP3	666	Q9BZ76
CARLHETQRENLLLR	CCDC88B	381	A6NC98
NPRLRLSCLSIRESE	CTC1	1191	Q2NKJ3
RNNRTRLALIICNTE	CASP4	131	P49662
FLELRVCSIQRNRSA	GTPBP2	451	Q9BX10
TFRRRQTCQLLLEVA	ABCA1	16	O95477
ESRRLSIQRCIQSLV	CREBBP	1766	Q92793
LYSRSLRLSQEICRL	ACSF3	71	Q4G176
RSCNVRDTALLARLL	ANKRD61	321	A6NGH8
RCDESNFRQVLQLLR	DEDD	76	O75618
NSCLIELRIQIRRFE	CCDC180	1436	Q9P1Z9
CRRNFLNRTSLLTLE	DHX29	1161	Q7Z478
RASQLRLQNLRASCE	CACNA1B	771	Q00975
QDALKALRLSRQRCL	ERCC6	1291	Q03468
QCLLRALRRSEALEA	ABHD15	81	Q6UXT9
DQRCRALLPSELRTL	ALPK1	36	Q96QP1
LLLSRRCQINIYDRL	ANKRD19P	86	Q9H560
IRALTLQLERLTLEC	CCDC39	171	Q9UFE4
LSQELCDRLSRHQIL	RAD51B	11	O15315
LLQCVSRVRDFLDRL	RASAL1	531	O95294
AESISLLELCRNTNR	RAD21	576	O60216
LTDKCTRLQRRVQDL	RFWD3	386	Q6PCD5
LSTGRRLDREQLCRQ	PCDH12	86	Q9NPG4
ERECQSQEELLLRSR	ARHGEF28	1476	Q8N1W1
LANRFQLQLLRERCE	ANKFY1	141	Q9P2R3
CVRDRATLSILAVRN	ATP23	181	Q9Y6H3
TRRRRIEIANNLCLN	HOXC5	181	Q00444
LRRVLDELTLCRTDQ	KRT28	196	Q7Z3Y7
LRNRIQRCTADSQLA	LRRC55	211	Q6ZSA7
NNRLAAEITRLRTLL	MPRIP	866	Q6WCQ1
LLQEREQLERRCATL	LZTS2	411	Q9BRK4
TLANRDRCRVAQLAL	KCNMA1	1091	Q12791
RARLECEINTYRSLL	KRT31	346	Q15323
QLARRCSEVRLLVDS	GEMIN2	236	O14893
IEALCSLLRRDASIN	INTS1	181	Q8N201
QSLRDRDRDQCILIT	MYO1A	86	Q9UBC5
RLLRQEASCLVDDTL	KCTD20	11	Q7Z5Y7
NCEDRLIRQIRTPLE	DST	1081	Q03001
SQQLQCIRELSSRRL	HEMK1	91	Q9Y5R4
LRSIQRSLLCRRQED	APH1A	236	Q96BI3
LLSQVRLVVRRALCQ	ASB12	271	Q8WXK4
LSLSDRVERNRLLLQ	KIAA1614	291	Q5VZ46
LNAELKRCRERTQTL	KIFC1	146	Q9BW19
LRRISLSRNKIADLC	EIF2B1	101	Q14232
DQNLQTALELTRRCL	IPO7	491	O95373
ARCVRLSAERAQALL	PGP	11	A6NDG6
NTRIQRDLCRQILFR	CSNKA2IP	441	A0A1B0GTH6
INGLRRVLDELTLCR	KRT27	191	Q7Z3Y8
RARLECEINTYRSLL	KRT33A	346	O76009
TRLLELSRNRIRCLN	LINGO3	56	P0C6S8
RQSNQILRERCEELL	IKBKG	66	Q9Y6K9
LTRRTLDRCQGNLET	ERCC2	251	P18074
RRQLQSLTCDLESLR	GFAP	286	P14136
LIQRLICSRERRLGQ	CDC42BPB	316	Q9Y5S2
RDLLLHDQCQITTLR	NLRX1	771	Q86UT6
CILTLILRTSSNDRR	DPY19L2	311	Q6NUT2
LLRELKNLDSRQCRE	RALGAPA2	1631	Q2PPJ7
VSLADREVISRLRNC	EXOSC2	226	Q13868
ICQDRSSLRQTIVRL	GREB1L	1876	Q9C091
DLIRRLCRQNPTERL	PRKG2	681	Q13237
NLLCLDVSENRLERL	LRRC1	221	Q9BTT6
ALNTEELRTLCRRLQ	OXR1	666	Q8N573
LLELNSERCRDAQRI	RBBP8NL	26	Q8NC74
RSLLFLDNCLRLQEE	QTRT2	166	Q9H974
LARLQVACDLLRRII	COG5	166	Q9UP83
EELLQRCISSALPRR	APC2	1626	O95996
SCLREAEELRTQLRL	CROCC	1151	Q5TZA2
SSVNDIQRLLFCLRR	FBH1	356	Q8NFZ0
SLQDLLLLVRCSVQR	ICE2	736	Q659A1
LQLRCRLRDDVQSIN	FGFR1	51	P11362
CRDLNKRLERETLQS	FILIP1L	396	Q4L180
ELCDSILQSRREREN	DIS3L	201	Q8TF46
LNLLDRCIKETLRLR	CYP51A1	366	Q16850
IRELNLSNCVRLSDA	FBXL13	481	Q8NEE6
TRLTQLNLDRCELTK	GP1BA	71	P07359
NLERRCRPNLSREVL	MBIP	16	Q9NS73
LELRIRLFCRNVLLD	FBXO47	211	Q5MNV8
RLREACVALQRQLSR	KANK3	551	Q6NY19
LLLVYRCTQQLRRDS	HERVK_113	651	Q902F9
ELLQSDERASQRCLR	CEP131	736	Q9UPN4
TEAARRLCLEENLSR	INAVA	201	Q3KP66
RLCLEENLSRQARRQ	INAVA	206	Q3KP66
DLQRCELLARLRQLE	CARD11	146	Q9BXL7
RTTRCLQLLAQEIRD	CCDC159	126	P0C7I6
LCSRDAKSRQLRQLL	OLFM3	76	Q96PB7
ERQRELAVKCLRLLT	KIF1A	1446	Q12756
RNNTRLLLEHLECLV	PPFIA2	131	O75334
DASFRRNLRQLITCR	NPBWR1	311	P48145
RSSVELELERCRQQA	PPEF2	391	O14830
REARECLTLLSQRLG	MTX1	321	Q13505
LLCRLADELLFRQIA	NR6A1	286	Q15406
RATRCKVERLQLLLQ	MIDN	386	Q504T8
LRRERLLRQNCADQI	MRPS30	306	Q9NP92
LRLCLAEERSRQATL	TARS3	71	A2RTX5
NAQLTIRCRQLLSEL	UVRAG	311	Q9P2Y5
FTRLRIQEERTLACL	THADA	1901	Q6YHU6
RQILRLLRLRCTEND	SYNE2	3421	Q8WXH0
ALQRSLEDLVDRCRQ	SYNE3	631	Q6ZMZ3
EDQVRCDIRQFLSLR	RECQL4	1136	O94761
ERERLLLQECLNLNS	FAM178B	216	Q8IXR5
TDLILNVRRTCRKLA	FBXL18	46	Q96ME1
RESERQLRLRLCVLN	PREX1	41	Q8TCU6
SADLLVNLSRCRRLI	SIGIRR	211	Q6IA17
LSRAQLLCQLRSRAR	ST6GAL2	246	Q96JF0
LLCQLRSRARVRTLD	ST6GAL2	251	Q96JF0
EDCRTLALRALLLLQ	TELO2	811	Q9Y4R8
SLCRARQRVEQEQLL	MUTYH	301	Q9UIF7
ERQLLCVARALLRNS	ABCC12	1261	Q96J65
AADAREVCQLLLRSR	NOTCH4	1676	Q99466
ECLRRSTQSLSLQRE	C11orf96	401	Q7Z7L8
CAEQLRQLARRITED	ATP11B	741	Q9Y2G3
QESLLRSRLSQLCVV	TMEM268	221	Q5VZI3
IARIERCNQLLRALK	ZER1	381	Q7Z7L7
TCQRLLQDISDTRLL	TRPA1	461	O75762
YRETCQLRLEDLLRQ	RORC	281	P51449
ERLVNETRECQSLRL	TPR	66	P12270
RSQEACLEAVLRRLQ	TEDC1	456	Q86SX3
EQQRCLLLARLRELE	TRIM15	181	Q9C019
RIVLERCYNDLRLLS	USP47	761	Q96K76
RSRAQRCLLLLVAIV	TOR4A	116	Q9NXH8
LSPQRRRELCTQLRQ	ZSWIM8	436	A7E2V4
IRLNRQRLLVCLEES	WIPI1	106	Q5MNZ9
QERASRPRLTILNVC	WNK2	1181	Q9Y3S1
ELQRRCNTLITLIER	SMARCA5	996	O60264
LILRCRQEARARFSQ	PICK1	296	Q9NRD5
VLSRRCVNLLKTALR	TRRAP	2121	Q9Y4A5
SRTRQRQLNEELCAL	WWC3	976	Q9ULE0
RQLNEELCALRELRQ	WWC3	981	Q9ULE0
LARSKLESLCRELQR	TXLNA	236	P40222
LESLCRELQRHNRSL	TXLNA	241	P40222
TVRDQAQRCSRVLLD	VPS13D	2011	Q5THJ4
EQALLIDLTSNSCRR	GOLGB1	3201	Q14789
RARLECEINTYRSLL	KRT33B	346	Q14525
EQLLGCRSRVLSRLL	LRIG2	11	O94898
IRNLRQRLEESICIN	PDE4DIP	1851	Q5VU43