Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

NSD3 NSD2

3.91e-061352GO:0046975
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A8 SLC6A20

1.27e-052352GO:0005283
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A8 SLC6A20

2.03e-052952GO:0005416
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

SLC6A8 SLC6A20

2.64e-053352GO:0072349
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A8 SLC6A20

2.97e-053552GO:0005343
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

NSD3 NSD2

4.73e-054452GO:0140938
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

NSD3 NSD2

1.14e-046852GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

NSD3 NSD2

1.17e-046952GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

NSD3 NSD2

1.24e-047152GO:0042054
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A8 SLC6A20

1.61e-048152GO:0015370
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC6A8 SLC6A20

1.69e-048352GO:0015101
GeneOntologyMolecularFunctionprotein methyltransferase activity

NSD3 NSD2

2.61e-0410352GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

NSD3 NSD2

2.71e-0410552GO:0008170
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A8 SLC6A20

2.71e-0410552GO:0015171
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A8 SLC6A20

3.48e-0411952GO:0015294
GeneOntologyMolecularFunctionsymporter activity

SLC6A8 SLC6A20

5.52e-0415052GO:0015293
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A8 SLC6A20

7.17e-0417152GO:0015081
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

NSD3 NSD2

7.25e-0417252GO:0008757
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC6A8 SLC6A20

1.05e-0320752GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC6A8 SLC6A20

1.06e-0320852GO:0005342
GeneOntologyMolecularFunctionmethyltransferase activity

NSD3 NSD2

1.11e-0321352GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

NSD3 NSD2

1.23e-0322452GO:0016741
GeneOntologyMolecularFunctionhistone modifying activity

NSD3 NSD2

1.28e-0322952GO:0140993
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC6A8 SLC6A20

2.08e-0329352GO:0008514
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A8 SLC6A20

2.13e-0329652GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A8 SLC6A20

2.20e-0330152GO:0022853
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A8 SLC6A20

5.16e-0346552GO:0046873
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A8 SLC6A20

5.43e-0347752GO:0022804
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A8 SLC6A20

9.24e-0362752GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A8 SLC6A20

1.03e-0266452GO:0008324
GeneOntologyMolecularFunctionchromatin binding

NSD2 MSH6

1.27e-0273952GO:0003682
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A8 SLC6A20

1.33e-0275852GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A8 SLC6A20

1.45e-0279352GO:0015075
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A8 SLC6A20

3.10e-02118052GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SLC6A8 SLC6A20

3.65e-02128952GO:0005215
GeneOntologyBiologicalProcessmodified amino acid transport

SLC6A8 SLC6A20

4.43e-054452GO:0072337
GeneOntologyBiologicalProcessisotype switching

NSD2 MSH6

8.27e-056052GO:0045190
GeneOntologyBiologicalProcesssomatic recombination of immunoglobulin genes involved in immune response

NSD2 MSH6

8.27e-056052GO:0002204
GeneOntologyBiologicalProcesssomatic diversification of immunoglobulins involved in immune response

NSD2 MSH6

8.27e-056052GO:0002208
GeneOntologyBiologicalProcesssomatic recombination of immunoglobulin gene segments

NSD2 MSH6

1.10e-046952GO:0016447
GeneOntologyBiologicalProcessimmunoglobulin production involved in immunoglobulin-mediated immune response

NSD2 MSH6

1.30e-047552GO:0002381
GeneOntologyBiologicalProcesssomatic diversification of immunoglobulins

NSD2 MSH6

1.37e-047752GO:0016445
GeneOntologyBiologicalProcesssomatic cell DNA recombination

NSD2 MSH6

1.55e-048252GO:0016444
GeneOntologyBiologicalProcesssomatic diversification of immune receptors via germline recombination within a single locus

NSD2 MSH6

1.55e-048252GO:0002562
GeneOntologyBiologicalProcesssomatic diversification of immune receptors

NSD2 MSH6

1.91e-049152GO:0002200
GeneOntologyBiologicalProcessB cell activation involved in immune response

NSD2 MSH6

2.35e-0410152GO:0002312
GeneOntologyBiologicalProcessregulation of DNA recombination

NSD2 MSH6

5.18e-0415052GO:0000018
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

SLC6A8 SLC6A20

6.11e-0416352GO:1905039
GeneOntologyBiologicalProcessorganic acid transmembrane transport

SLC6A8 SLC6A20

6.41e-0416752GO:1903825
GeneOntologyBiologicalProcessamino acid transport

SLC6A8 SLC6A20

8.73e-0419552GO:0006865
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A8 SLC6A20

9.92e-0420852GO:0035725
GeneOntologyBiologicalProcessmethylation

NSD3 NSD2

1.25e-0323452GO:0032259
GeneOntologyBiologicalProcessimmunoglobulin mediated immune response

NSD2 MSH6

1.26e-0323552GO:0016064
GeneOntologyBiologicalProcessimmunoglobulin production

NSD2 MSH6

1.33e-0324152GO:0002377
GeneOntologyBiologicalProcessB cell mediated immunity

NSD2 MSH6

1.36e-0324452GO:0019724
GeneOntologyBiologicalProcessimmune system development

NSD2 MSH6

1.41e-0324852GO:0002520
GeneOntologyBiologicalProcesslymphocyte activation involved in immune response

NSD2 MSH6

1.44e-0325152GO:0002285
GeneOntologyBiologicalProcesssodium ion transport

SLC6A8 SLC6A20

1.72e-0327552GO:0006814
GeneOntologyBiologicalProcessB cell activation

NSD2 MSH6

2.64e-0334152GO:0042113
GeneOntologyBiologicalProcessleukocyte activation involved in immune response

NSD2 MSH6

2.95e-0336152GO:0002366
GeneOntologyBiologicalProcesscell activation involved in immune response

NSD2 MSH6

3.01e-0336552GO:0002263
GeneOntologyBiologicalProcessDNA recombination

NSD2 MSH6

3.06e-0336852GO:0006310
GeneOntologyBiologicalProcessproduction of molecular mediator of immune response

NSD2 MSH6

3.66e-0340352GO:0002440
GeneOntologyBiologicalProcesscarboxylic acid transport

SLC6A8 SLC6A20

3.79e-0341052GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

SLC6A8 SLC6A20

3.82e-0341252GO:0015849
GeneOntologyBiologicalProcesslymphocyte mediated immunity

NSD2 MSH6

4.53e-0344952GO:0002449
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

NSD2 MSH6

4.79e-0346252GO:0002460
GeneOntologyBiologicalProcessorganic anion transport

SLC6A8 SLC6A20

5.92e-0351552GO:0015711
GeneOntologyBiologicalProcessregulation of DNA metabolic process

NSD2 MSH6

7.07e-0356452GO:0051052
GeneOntologyBiologicalProcessleukocyte mediated immunity

NSD2 MSH6

7.36e-0357652GO:0002443
GeneOntologyBiologicalProcessDNA repair

NSD2 MSH6

9.25e-0364852GO:0006281
GeneOntologyBiologicalProcesschromatin remodeling

NSD3 NSD2

1.20e-0274152GO:0006338
GeneOntologyBiologicalProcessadaptive immune response

NSD2 MSH6

1.52e-0283852GO:0002250
GeneOntologyBiologicalProcessimmune effector process

NSD2 MSH6

1.59e-0285952GO:0002252
GeneOntologyBiologicalProcesschromatin organization

NSD3 NSD2

1.73e-0289652GO:0006325
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC6A8 SLC6A20

1.82e-0292252GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC6A8 SLC6A20

1.90e-0294252GO:0098655
GeneOntologyBiologicalProcessDNA damage response

NSD2 MSH6

1.97e-0295952GO:0006974
GeneOntologyBiologicalProcesslymphocyte activation

NSD2 MSH6

2.03e-0297652GO:0046649
GeneOntologyBiologicalProcessprotein-DNA complex organization

NSD3 NSD2

2.13e-0299952GO:0071824
GeneOntologyCellularComponentchromatin

NSD3 NSD2 MSH6

3.18e-03148053GO:0000785
GeneOntologyCellularComponentapical plasma membrane

SLC6A8 SLC6A20

5.17e-0348752GO:0016324
GeneOntologyCellularComponentapical part of cell

SLC6A8 SLC6A20

7.56e-0359252GO:0045177
DomainPWWP

NSD3 NSD2 MSH6

1.05e-082053SM00293
DomainPWWP

NSD3 NSD2 MSH6

1.63e-082353PF00855
DomainPWWP_dom

NSD3 NSD2 MSH6

1.63e-082353IPR000313
DomainPWWP

NSD3 NSD2 MSH6

1.86e-082453PS50812
DomainAWS

NSD3 NSD2

5.73e-07552PS51215
DomainAWS_dom

NSD3 NSD2

5.73e-07552IPR006560
DomainAWS

NSD3 NSD2

5.73e-07552SM00570
DomainPostSET

NSD3 NSD2

6.87e-061652SM00508
DomainPOST_SET

NSD3 NSD2

6.87e-061652PS50868
DomainPost-SET_dom

NSD3 NSD2

6.87e-061652IPR003616
DomainNA_NEUROTRAN_SYMP_2

SLC6A8 SLC6A20

8.76e-061852PS00754
DomainNa/ntran_symport

SLC6A8 SLC6A20

9.79e-061952IPR000175
DomainSNF

SLC6A8 SLC6A20

9.79e-061952PF00209
DomainNA_NEUROTRAN_SYMP_3

SLC6A8 SLC6A20

9.79e-061952PS50267
DomainNA_NEUROTRAN_SYMP_1

SLC6A8 SLC6A20

9.79e-061952PS00610
DomainSET

NSD3 NSD2

4.68e-054152PF00856
DomainSET

NSD3 NSD2

5.91e-054652SM00317
DomainSET_dom

NSD3 NSD2

6.99e-055052IPR001214
DomainSET

NSD3 NSD2

6.99e-055052PS50280
DomainZinc_finger_PHD-type_CS

NSD3 NSD2

1.18e-046552IPR019786
DomainPHD

NSD3 NSD2

1.58e-047552PF00628
DomainZnf_PHD-finger

NSD3 NSD2

1.75e-047952IPR019787
DomainPHD

NSD3 NSD2

2.22e-048952SM00249
DomainZnf_PHD

NSD3 NSD2

2.33e-049152IPR001965
DomainZF_PHD_2

NSD3 NSD2

2.53e-049552PS50016
DomainZF_PHD_1

NSD3 NSD2

2.59e-049652PS01359
DomainZnf_FYVE_PHD

NSD3 NSD2

6.06e-0414752IPR011011
DomainRING

NSD3 NSD2

2.57e-0330552SM00184
DomainZnf_RING

NSD3 NSD2

2.93e-0332652IPR001841
Domain-

NSD3 NSD2

5.50e-03449523.30.40.10
DomainZnf_RING/FYVE/PHD

NSD3 NSD2

5.74e-0345952IPR013083
PathwayKEGG_LYSINE_DEGRADATION

NSD3 NSD2

9.46e-054452M13720
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

NSD3 NSD2

1.04e-044652MM14933
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

NSD3 NSD2

2.41e-047052M27231
PathwayWP_NRF2_PATHWAY

SLC6A8 SLC6A20

9.74e-0414152M39454
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

NSD3 NSD2

1.50e-0317552MM14941
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

NSD3 NSD2

3.57e-0327252M29619
PathwayREACTOME_DNA_REPAIR

NSD2 MSH6

4.35e-0330152MM15433
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

SLC6A8 SLC6A20

4.73e-0331452M39428
PathwayREACTOME_DNA_REPAIR

NSD2 MSH6

5.28e-0333252M15434
Pubmed

A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.

NSD3 NSD2 MSH6

5.19e-10145326912663
Pubmed

Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy.

NSD3 NSD2

1.65e-0825234083510
Pubmed

The histone methyltransferase activity of WHISTLE is important for the induction of apoptosis and HDAC1-mediated transcriptional repression.

NSD3 NSD2

4.96e-0835217239852
Pubmed

The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.

NSD3 NSD2

4.96e-0835223269674
Pubmed

The NSD family of protein methyltransferases in human cancer.

NSD3 NSD2

4.96e-0835225942451
Pubmed

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.

NSD3 NSD2

4.96e-0835233361816
Pubmed

The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.

NSD3 NSD2

4.96e-0835235532818
Pubmed

Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity.

NSD3 NSD2

4.96e-0835216682010
Pubmed

Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.

NSD3 NSD2

9.92e-0845234271259
Pubmed

Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.

NSD3 NSD2

1.65e-0755239390582
Pubmed

In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.

NSD3 NSD2

1.65e-0755225494638
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A8 SLC6A20

3.47e-06215216125675
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

NSD3 NSD2 MSH6

1.18e-053705322922362
Pubmed

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

NSD3 NSD2

2.63e-05575221555454
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

NSD3 NSD2 MSH6

3.50e-055335330554943
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

NSD3 NSD2 MSH6

5.18e-056085336089195
Pubmed

ATRX proximal protein associations boast roles beyond histone deposition.

NSD3 NSD2

6.74e-05915234780483
Pubmed

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

NSD3 MSH6

7.34e-05955229490077
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

NSD3 NSD2

9.67e-051095233554859
InteractionCDC14B interactions

NSD3 NSD2 MSH6

4.67e-0615853int:CDC14B
InteractionCENPA interactions

NSD3 NSD2 MSH6

6.32e-0537753int:CENPA
InteractionFOXP3 interactions

NSD3 NSD2 MSH6

9.47e-0543253int:FOXP3
InteractionZNF330 interactions

NSD3 NSD2 MSH6

1.04e-0444653int:ZNF330
InteractionCCDC71 interactions

NSD3 NSD2

1.25e-047252int:CCDC71
InteractionH3C3 interactions

NSD3 NSD2 MSH6

1.42e-0449553int:H3C3
InteractionRFT1 interactions

SLC6A8 SLC6A20

1.54e-048052int:RFT1
InteractionCOIL interactions

NSD3 NSD2 MSH6

1.96e-0455253int:COIL
InteractionH2BC8 interactions

NSD3 NSD2 MSH6

2.23e-0457653int:H2BC8
InteractionBRD9 interactions

NSD3 MSH6

3.30e-0411752int:BRD9
InteractionDTL interactions

NSD2 MSH6

3.42e-0411952int:DTL
InteractionH2BC21 interactions

NSD3 NSD2 MSH6

3.89e-0469653int:H2BC21
InteractionH3-3A interactions

NSD3 NSD2 MSH6

4.83e-0474953int:H3-3A
InteractionZBTB38 interactions

NSD3 MSH6

5.07e-0414552int:ZBTB38
InteractionTWIST1 interactions

NSD3 NSD2

6.96e-0417052int:TWIST1
InteractionH3C1 interactions

NSD3 NSD2 MSH6

8.32e-0490153int:H3C1
InteractionMNDA interactions

NSD3 NSD2

8.50e-0418852int:MNDA
InteractionFEN1 interactions

NSD2 MSH6

8.95e-0419352int:FEN1
InteractionCHD8 interactions

NSD3 MSH6

8.95e-0419352int:CHD8
InteractionSORT1 interactions

SLC6A8 NSD2

1.04e-0320852int:SORT1
InteractionNUCKS1 interactions

NSD2 MSH6

1.16e-0322052int:NUCKS1
InteractionRAD51 interactions

NSD3 MSH6

1.39e-0324152int:RAD51
InteractionDGCR8 interactions

NSD2 MSH6

1.40e-0324252int:DGCR8
GeneFamilyPWWP domain containing

NSD3 NSD2 MSH6

1.56e-0822531147
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD3 NSD2

3.42e-053452487
GeneFamilyPHD finger proteins

NSD3 NSD2

2.43e-04905288
GeneFamilySolute carriers

SLC6A8 SLC6A20

4.56e-0339552752
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_G_DN

SLC6A8 NSD2

1.63e-053452M11023
CoexpressionGRESHOCK_CANCER_COPY_NUMBER_UP

NSD3 NSD2 MSH6

1.82e-0532353M9150
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_G_DN

SLC6A8 NSD2

1.83e-053652MM486
CoexpressionMATTIOLI_MGUS_VS_PCL

NSD2 MSH6

2.31e-0412752M10973
CoexpressionGEORGES_TARGETS_OF_MIR192_AND_MIR215

NSD3 NSD2 MSH6

3.73e-0489253M18120
CoexpressionWINNEPENNINCKX_MELANOMA_METASTASIS_UP

NSD2 MSH6

3.75e-0416252M6387
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN

SLC6A8 NSD2 MSH6

3.95e-0490953M41018
CoexpressionGSE17974_0.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_DN

NSD2 MSH6

5.48e-0419652M4245
CoexpressionGSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_9H_UP

SLC6A8 NSD2

5.65e-0419952M6198
CoexpressionGSE360_T_GONDII_VS_M_TUBERCULOSIS_MAC_UP

SLC6A8 MSH6

5.65e-0419952M5258
CoexpressionGSE3039_NKT_CELL_VS_ALPHABETA_CD8_TCELL_UP

SLC6A8 MSH6

5.71e-0420052M6429
CoexpressionGSE3920_UNTREATED_VS_IFNB_TREATED_ENDOTHELIAL_CELL_UP

NSD3 SLC6A20

5.71e-0420052M6686
CoexpressionGSE4748_CTRL_VS_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP

NSD3 SLC6A20

5.71e-0420052M6477
CoexpressionGSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP

NSD2 MSH6

5.71e-0420052M3459
CoexpressionCHICAS_RB1_TARGETS_GROWING

NSD2 MSH6

8.34e-0424252M2128
CoexpressionMITSIADES_RESPONSE_TO_APLIDIN_DN

NSD2 MSH6

8.89e-0425052M11318
CoexpressionBUSSLINGER_DUODENAL_MATURE_ENTEROCYTES

SLC6A8 SLC6A20

9.54e-0425952M40029
CoexpressionDEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN

SLC6A8 MSH6

1.08e-0327652M3063
CoexpressionKINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP

NSD3 NSD2 MSH6

1.10e-03129053M80
CoexpressionFOURNIER_ACINAR_DEVELOPMENT_LATE_2

NSD2 MSH6

1.12e-0328152M4077
CoexpressionTBK1.DF_DN

SLC6A8 NSD3

1.16e-0328652M2864
CoexpressionDODD_NASOPHARYNGEAL_CARCINOMA_UP

NSD3 NSD2 MSH6

1.42e-03140753M14427
CoexpressionSMID_BREAST_CANCER_RELAPSE_IN_BONE_DN

NSD2 MSH6

1.49e-0332452M2700
CoexpressionBENPORATH_ES_1

SLC6A8 MSH6

2.03e-0337952M1871
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_LARGE_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

NSD2 MSH6

2.28e-0340252MM454
CoexpressionVECCHI_GASTRIC_CANCER_EARLY_UP

SLC6A8 NSD2

2.67e-0343652M18855
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_CYCLING_DEFINITIVE_ERYTHROBLAST

SLC6A8 NSD2

2.84e-0345052M45747
CoexpressionTOYOTA_TARGETS_OF_MIR34B_AND_MIR34C

NSD3 NSD2

2.89e-0345452M19927
CoexpressionSHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6

NSD2 MSH6

2.94e-0345852M8520
CoexpressionLIAO_METASTASIS

SLC6A8 NSD2

4.07e-0354052M13809
CoexpressionCHICAS_RB1_TARGETS_SENESCENT

NSD3 MSH6

4.44e-0356552M2125
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP

NSD2 MSH6

4.64e-0357852M2368
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP

NSD2 MSH6

4.95e-0359752MM1309
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

SLC6A8 MSH6

5.18e-0361152M1106
CoexpressionCAIRO_HEPATOBLASTOMA_CLASSES_UP

NSD2 MSH6

5.19e-0361252M4772
CoexpressionTABULA_MURIS_SENIS_SKIN_EPIDERMAL_CELL_AGEING

SLC6A8 NSD3

5.29e-0361852MM3829
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

SLC6A8 MSH6

5.79e-0364752MM981
CoexpressionSMID_BREAST_CANCER_BASAL_UP

NSD2 MSH6

6.05e-0366252M8124
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_SMALL_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

NSD2 MSH6

6.38e-0368052MM456
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_NK_CELL

NSD2 MSH6

6.64e-0369452M45767
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN

SLC6A8 NSD3

7.64e-0374652M40863
CoexpressionPUJANA_CHEK2_PCC_NETWORK

NSD2 MSH6

7.94e-0376152M11961
CoexpressionJOHNSTONE_PARVB_TARGETS_3_DN

NSD3 MSH6

1.05e-0287752M2241
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_T_CELL

NSD2 MSH6

1.19e-0293952M45768
CoexpressionKRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN

NSD3 MSH6

1.22e-0295052M19907
CoexpressionFISCHER_DREAM_TARGETS

NSD2 MSH6

1.27e-0296952M149
CoexpressionTABULA_MURIS_SENIS_SKIN_BASAL_CELL_OF_EPIDERMIS_AGEING

SLC6A8 NSD3

1.36e-02100552MM3827
CoexpressionTABULA_MURIS_SENIS_BRAIN_NON_MYELOID_OLIGODENDROCYTE_AGEING

SLC6A8 NSD3

1.73e-02113952MM3690
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

SLC6A8 MSH6

1.76e-02115152M1103
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

SLC6A8 MSH6

1.13e-04152526f9c343669883618cd9c1c8921a90c34d153f303
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

SLC6A8 MSH6

1.65e-0418452ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCellPBMC-Severe-cDC_12|Severe / Compartment, Disease Groups and Clusters

NSD2 MSH6

1.76e-041905284ee185939bdefb10705b621a70da27701eadcee
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A8 NSD2

1.78e-0419152c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SLC6A20

1.91e-0419852ecdef1a0a0b8399e193b922c8ca8c25e63de4a4f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SLC6A20

1.93e-0419952f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SLC6A20

1.93e-0419952914f66e2b4af323d09fa2340a39cf8051d00a422
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SLC6A20

1.93e-0419952a10768e1cddd2d38291c30d24820a94040a72211
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

NSD2 MSH6

1.95e-042005204bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

NSD2 MSH6

1.95e-04200527e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SLC6A20

1.95e-04200523e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SLC6A20

1.95e-042005273bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

NSD2 MSH6

1.95e-04200529775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

NSD2 MSH6

1.95e-0420052f6b5320cdfe640a71e6e2df26f30d42e64b1c921
DrugPyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; HL60; HT_HG-U133A

SLC6A8 NSD2 MSH6

4.88e-06181532957_DN
DrugPiperine [94-62-2]; Down 200; 14uM; MCF7; HT_HG-U133A

SLC6A8 NSD2 MSH6

5.83e-06192534830_DN
DrugCyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

SLC6A8 NSD2 MSH6

6.20e-06196534834_DN
DrugMephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; PC3; HT_HG-U133A

NSD3 NSD2 MSH6

6.20e-06196533685_DN
DrugPergolide mesylate [66104-23-2]; Up 200; 9.8uM; PC3; HT_HG-U133A

NSD3 NSD2 MSH6

6.20e-06196537271_UP
DrugGSK-3 Inhibitor IX; Down 200; 0.5uM; MCF7; HT_HG-U133A

NSD3 NSD2 MSH6

6.40e-06198536589_DN
Drugguanidinoacetate

SLC6A8 SLC6A20

5.09e-055252CID000000763
Drugtricarballylate

NSD3 NSD2

6.57e-055952CID000014925
DrugNSC407322

SLC6A8 MSH6

3.25e-0413152CID000003977
DrugDigitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

5.15e-04165523275_UP
DrugStrophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

5.33e-04168526087_UP
DrugCephaeline dihydrochloride heptahydrate [6487-30-5]; Down 200; 6uM; HL60; HT_HG-U133A

SLC6A8 NSD2

5.53e-04171522429_DN
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

NSD2 MSH6

5.92e-04177524652_DN
Drug1,5-AG

NSD2 MSH6

6.26e-0418252CID000064960
DrugPuromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; PC3; HT_HG-U133A

NSD2 MSH6

6.46e-04185526711_DN
DrugCefadroxil [50370-12-2]; Down 200; 11uM; HL60; HT_HG-U133A

NSD2 MSH6

6.53e-04186521323_DN
DrugProgesterone [57-83-0]; Down 200; 12.8uM; HL60; HT_HG-U133A

SLC6A8 NSD3

6.53e-04186522426_DN
DrugAG-1478; Down 200; 31.6uM; MCF7; HT_HG-U133A_EA

NSD2 MSH6

6.60e-04187521141_DN
DrugPicrotoxinin [17617-45-7]; Down 200; 13.6uM; HL60; HT_HG-U133A

NSD2 MSH6

6.67e-04188522161_DN
DrugPrimaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A

NSD2 MSH6

6.67e-04188524845_DN
DrugPromethazine hydrochloride [58-33-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

NSD2 MSH6

6.74e-04189526717_DN
DrugMitoxantrone dihydrochloride [70476-82-3]; Up 200; 7.8uM; MCF7; HT_HG-U133A

SLC6A8 SLC6A20

6.81e-04190523232_UP
DrugDeptropine citrate [2169-75-7]; Down 200; 7.6uM; HL60; HT_HG-U133A

NSD2 MSH6

6.81e-04190523144_DN
DrugProstaglandin E1; Up 200; 10uM; PC3; HT_HG-U133A

NSD2 MSH6

6.81e-04190526571_UP
DrugPaclitaxel [33069-62-4]; Down 200; 4.6uM; PC3; HT_HG-U133A

NSD2 MSH6

6.89e-04191526720_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT_HG-U133A

NSD2 MSH6

6.89e-04191524299_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; PC3; HT_HG-U133A

SLC6A8 NSD2

6.89e-04191526721_DN
Drug2-propylpentanoic acid; Down 200; 200uM; HL60; HT_HG-U133A

NSD2 MSH6

6.89e-04191526173_DN
DrugFlunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT_HG-U133A

NSD3 NSD2

6.89e-04191524273_DN
Drug0317956-0000 [391210-11-0]; Down 200; 1uM; PC3; HT_HG-U133A

SLC6A20 MSH6

6.96e-04192524334_DN
DrugPNU-0293363 [326823-19-2]; Up 200; 10uM; MCF7; HT_HG-U133A

NSD2 MSH6

6.96e-04192526573_UP
DrugTracazolate hydrochloride [41094-88-6]; Down 200; 11.8uM; HL60; HT_HG-U133A

SLC6A8 NSD3

6.96e-04192522919_DN
DrugTriprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; PC3; HT_HG-U133A

NSD3 NSD2

6.96e-04192527248_UP
DrugTriflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

6.96e-04192527466_DN
DrugHesperidin [520-26-3]; Down 200; 6.6uM; PC3; HT_HG-U133A

NSD2 MSH6

6.96e-04192526714_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

NSD3 SLC6A20

6.96e-04192525218_UP
DrugPF-00562151-00 [351320-12-2]; Down 200; 10uM; PC3; HT_HG-U133A

NSD3 NSD2

6.96e-04192525959_DN
DrugCephalexin monohydrate [23325-78-2]; Down 200; 11uM; HL60; HT_HG-U133A

NSD2 MSH6

6.96e-04192521273_DN
DrugPipemidic acid [51940-44-4]; Down 200; 13.2uM; PC3; HT_HG-U133A

NSD2 MSH6

6.96e-04192526752_DN
DrugEnilconazole [35554-44-0]; Down 200; 13.4uM; HL60; HT_HG-U133A

SLC6A8 NSD3

7.03e-04193523139_DN
DrugGramine [87-52-5]; Up 200; 23uM; MCF7; HT_HG-U133A

NSD3 SLC6A20

7.03e-04193524118_UP
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; PC3; HT_HG-U133A

NSD2 MSH6

7.03e-04193526716_DN
DrugCarisoprodol [78-44-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A

NSD3 MSH6

7.03e-04193523251_UP
DrugAmiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A

NSD3 SLC6A20

7.03e-04193523296_UP
DrugNaphazoline hydrochloride [550-99-2]; Down 200; 16.2uM; PC3; HT_HG-U133A

NSD3 NSD2

7.03e-04193526604_DN
DrugCeforanide [60925-61-3]; Down 200; 7.6uM; PC3; HT_HG-U133A

SLC6A8 NSD2

7.03e-04193526751_DN
DrugCarbetapentane citrate [23142-01-0]; Down 200; 7.6uM; HL60; HT_HG-U133A

NSD3 NSD2

7.03e-04193521268_DN
DrugHaloperidol [52-86-8]; Up 200; 10.6uM; PC3; HT_HG-U133A

NSD2 SLC6A20

7.10e-04194524678_UP
DrugMoxalactam disodium salt [64953-12-4]; Down 200; 7uM; PC3; HT_HG-U133A

NSD2 MSH6

7.10e-04194524648_DN
DrugUngerine nitrate; Down 200; 10.2uM; MCF7; HT_HG-U133A

SLC6A8 SLC6A20

7.10e-04194526076_DN
DrugBenserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; PC3; HT_HG-U133A

SLC6A8 NSD2

7.10e-04194526722_DN
DrugNifedipine [21829-25-4]; Up 200; 11.6uM; PC3; HT_HG-U133A

NSD3 NSD2

7.10e-04194521814_UP
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA

SLC6A8 NSD3

7.10e-04194521060_UP
DrugHexestrol [84-16-2]; Down 200; 14.8uM; HL60; HT_HG-U133A

SLC6A8 NSD2

7.10e-04194522515_DN
DrugScopoletin [92-61-5]; Up 200; 20.8uM; MCF7; HT_HG-U133A

NSD2 SLC6A20

7.10e-04194526510_UP
DrugNitrofurantoin [67-20-9]; Down 200; 16.8uM; PC3; HT_HG-U133A

NSD3 NSD2

7.10e-04194523674_DN
DrugThonzonium bromide [553-08-2]; Down 200; 6.8uM; PC3; HT_HG-U133A

NSD2 MSH6

7.10e-04194524617_DN
DrugPrimidone [125-33-7]; Down 200; 18.4uM; PC3; HT_HG-U133A

SLC6A8 NSD2

7.10e-04194526723_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NSD2 MSH6

7.10e-04194525017_DN
DrugButoconazole nitrate [32872-77-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

SLC6A8 NSD3

7.10e-04194522427_DN
Drug16-phenyl tetranor Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A

NSD2 MSH6

7.18e-04195527509_DN
DrugArecoline hydrobromide [300-08-3]; Down 200; 17uM; HL60; HT_HG-U133A

NSD2 MSH6

7.18e-04195521303_DN
DrugCyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

7.18e-04195523268_UP
DrugBeta-sistosterol [83-46-5]; Down 200; 9.6uM; PC3; HT_HG-U133A

NSD3 SLC6A20

7.18e-04195524073_DN
DrugIndapamide [26807-65-8]; Down 200; 10.6uM; PC3; HT_HG-U133A

NSD3 NSD2

7.18e-04195523778_DN
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

SLC6A8 NSD2

7.18e-04195521162_DN
DrugErythromycin [114-07-8]; Down 200; 5.4uM; PC3; HG-U133A

SLC6A8 NSD2

7.18e-04195521928_DN
DrugSpironolactone [52-01-7]; Up 200; 9.6uM; PC3; HT_HG-U133A

SLC6A8 NSD2

7.18e-04195522064_UP
DrugPHA-00665752 [477575-56-7]; Down 200; 10uM; MCF7; HT_HG-U133A

NSD2 MSH6

7.18e-04195526578_DN
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; PC3; HT_HG-U133A

NSD2 MSH6

7.18e-04195526643_DN
DrugFurazolidone [67-45-8]; Down 200; 17.8uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

7.18e-04195523358_DN
DrugEtifenin [63245-28-3]; Up 200; 12.4uM; PC3; HT_HG-U133A

SLC6A8 SLC6A20

7.25e-04196523998_UP
DrugPNU-0293363 [326823-19-2]; Up 200; 10uM; PC3; HT_HG-U133A

NSD2 MSH6

7.25e-04196526568_UP
DrugPHA-00767505E [723337-45-9]; Down 200; 10uM; MCF7; HT_HG-U133A

NSD2 MSH6

7.25e-04196526596_DN
DrugLetrozole [112809-51-5]; Up 200; 14uM; MCF7; HT_HG-U133A

NSD2 MSH6

7.25e-04196524824_UP
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; PC3; HT_HG-U133A

NSD3 NSD2

7.25e-04196524683_UP
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; HL60; HT_HG-U133A

NSD2 MSH6

7.25e-04196522511_DN
DrugCalciferol [50-14-6]; Up 200; 10uM; HL60; HT_HG-U133A

NSD2 MSH6

7.25e-04196522442_UP
DrugPyrantel tartrate [33401-94-4]; Up 200; 11.2uM; PC3; HT_HG-U133A

NSD3 SLC6A20

7.25e-04196525088_UP
DrugIoxaglic acid [59017-64-0]; Down 200; 3.2uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

7.25e-04196527470_DN
DrugGly-His-Lys acetate salt; Up 200; 1uM; PC3; HT_HG-U133A

NSD2 MSH6

7.25e-04196526570_UP
DrugAntazoline hydrochloride [2508-72-7]; Up 200; 13.2uM; PC3; HT_HG-U133A

NSD3 NSD2

7.25e-04196527128_UP
DrugNiflumic acid [4394-00-7]; Down 200; 14.2uM; MCF7; HT_HG-U133A

SLC6A8 NSD3

7.25e-04196527430_DN
DrugTetracycline hydrochloride [64-75-5]; Up 200; 8.4uM; PC3; HT_HG-U133A

SLC6A8 NSD2

7.25e-04196522080_UP
DrugOrlistat; Down 200; 10uM; MCF7; HT_HG-U133A

NSD2 MSH6

7.25e-04196526905_DN
DrugAzaperone [1649-18-9]; Down 200; 12.2uM; PC3; HT_HG-U133A

SLC6A8 NSD3

7.25e-04196525877_DN
DrugMecamylamine hydrochloride [826-39-1]; Up 200; 19.6uM; PC3; HT_HG-U133A

NSD3 MSH6

7.25e-04196527263_UP
DrugGuaifenesin [93-14-1]; Up 200; 20.2uM; MCF7; HT_HG-U133A

NSD3 NSD2

7.32e-04197523431_UP
DrugMenadione [58-27-5]; Down 200; 23.2uM; HL60; HT_HG-U133A

NSD3 MSH6

7.32e-04197522439_DN
DrugDihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; PC3; HT_HG-U133A

NSD3 SLC6A20

7.32e-04197525751_UP
DrugBepridil hydrochloride [74764-40-2]; Down 200; 10uM; PC3; HT_HG-U133A

NSD2 MSH6

7.32e-04197524613_DN
DrugScopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A

SLC6A8 MSH6

7.32e-04197524803_UP
Drugionomycin calcium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA

NSD2 MSH6

7.32e-0419752882_DN
DiseaseSotos syndrome 1 (implicated_via_orthology)

NSD3 NSD2

6.89e-08352DOID:0112103 (implicated_via_orthology)
Diseasesyndrome (implicated_via_orthology)

NSD3 NSD2

3.51e-061852DOID:225 (implicated_via_orthology)
DiseaseIntellectual Disability

SLC6A8 NSD2

2.22e-0344752C3714756

Protein segments in the cluster

PeptideGeneStartEntry
VWSKVSGYPWWPCMV

NSD2

226

O96028
VWAKMEGYPWWPCLV

MSH6

96

P52701
IGYRPCPWMKWCWSF

SLC6A8

511

P48029
VSWYWKVMWAGVSPL

SLC6A20

501

Q9NP91
SKVGTYPWWPCMVSS

NSD3

276

Q9BZ95