Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsweet taste receptor activity

TAS1R3 TAS1R2

2.05e-052912GO:0033041
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH6 MYH7 MYH7B MYO19

2.65e-0538914GO:0000146
GeneOntologyMolecularFunctionceramide phosphoethanolamine synthase activity

SGMS1 SAMD8

6.14e-053912GO:0002950
GeneOntologyMolecularFunctionceramide cholinephosphotransferase activity

SGMS1 SAMD8

6.14e-053912GO:0047493
GeneOntologyMolecularFunctionglycogen phosphorylase activity

PYGL PYGM

6.14e-053912GO:0008184
GeneOntologyMolecularFunctionsphingomyelin synthase activity

SGMS1 SAMD8

6.14e-053912GO:0033188
GeneOntologyMolecularFunction1,4-alpha-oligoglucan phosphorylase activity

PYGL PYGM

2.04e-045912GO:0004645
GeneOntologyMolecularFunctionprotein kinase activity

MST1R FRK PLK2 TBK1 DAPK1 PEAK1 MELK CDC42BPB MMD ALPK2

4.02e-046009110GO:0004672
GeneOntologyMolecularFunctionkinase activity

MST1R FRK PLK2 SGMS1 TBK1 DAPK1 PEAK1 MELK CDC42BPB MMD ALPK2

6.98e-047649111GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

MST1R FRK PLK2 SGMS1 SAMD8 TBK1 DAPK1 PEAK1 MELK CDC42BPB MMD ALPK2

1.11e-039389112GO:0016772
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

FRK PEAK1 MELK

1.21e-0346913GO:0004715
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

MST1R FRK PLK2 TBK1 DAPK1 PEAK1 MELK CDC42BPB MMD ALPK2

1.44e-037099110GO:0016773
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of sweet taste

TAS1R3 TAS1R2

1.88e-052902GO:0001582
GeneOntologyCellularComponentsweet taste receptor complex

TAS1R3 TAS1R2

1.92e-052922GO:1903767
GeneOntologyCellularComponenttaste receptor complex

TAS1R3 TAS1R2

1.92e-052922GO:1903768
GeneOntologyCellularComponentactin cytoskeleton

MST1R MYADM MYH6 MYH7 MYH7B MYO19 ANKRD26 DAPK1 ACTL9 PEAK1 CDC42BPB

4.51e-055769211GO:0015629
GeneOntologyCellularComponentmyosin complex

MYH6 MYH7 MYH7B MYO19

1.33e-0459924GO:0016459
GeneOntologyCellularComponentmyosin filament

MYH6 MYH7 MYH7B

1.77e-0425923GO:0032982
GeneOntologyCellularComponentmyosin II complex

MYH6 MYH7 MYH7B

2.50e-0428923GO:0016460
GeneOntologyCellularComponentlaminin complex

NTN4 LAMA3

8.43e-0410922GO:0043256
GeneOntologyCellularComponenttransferase complex

CCNJL UBR2 SPTLC3 ZZZ3 ANKRD9 TBK1 DAPK1 E2F6 WDFY3 ACTL9 CCNJ CUL7

1.04e-039639212GO:1990234
DomainMyosin_head_motor_dom

MYH6 MYH7 MYO15B MYH7B MYO19

1.03e-0638905IPR001609
DomainMYOSIN_MOTOR

MYH6 MYH7 MYO15B MYH7B MYO19

1.03e-0638905PS51456
DomainMyosin_head

MYH6 MYH7 MYO15B MYH7B MYO19

1.03e-0638905PF00063
DomainMYSc

MYH6 MYH7 MYO15B MYH7B MYO19

1.03e-0638905SM00242
DomainLaminin_G

FAT2 FAT3 LAMA3 COL14A1 USH2A

8.70e-0658905IPR001791
DomainLAM_G_DOMAIN

FAT2 FAT3 LAMA3 USH2A

3.28e-0538904PS50025
DomainLaminin_G_2

FAT2 FAT3 LAMA3 USH2A

4.04e-0540904PF02210
DomainMyosin_N

MYH6 MYH7 MYH7B

4.72e-0515903PF02736
DomainMyosin_N

MYH6 MYH7 MYH7B

4.72e-0515903IPR004009
DomainLaminin_N

NTN4 LAMA3 USH2A

5.79e-0516903IPR008211
DomainLAMININ_NTER

NTN4 LAMA3 USH2A

5.79e-0516903PS51117
DomainLaminin_N

NTN4 LAMA3 USH2A

5.79e-0516903PF00055
DomainLamNT

NTN4 LAMA3 USH2A

5.79e-0516903SM00136
DomainLamG

FAT2 FAT3 LAMA3 USH2A

5.91e-0544904SM00282
DomainPHOSPHORYLASE

PYGL PYGM

6.87e-053902PS00102
DomainSphingomyelin_synth-like_dom

SGMS1 SAMD8

6.87e-053902IPR025749
DomainPhosphorylase

PYGL PYGM

6.87e-053902PF00343
DomainGlycg_phsphrylas

PYGL PYGM

6.87e-053902IPR011833
DomainPAP2_C

SGMS1 SAMD8

6.87e-053902PF14360
DomainGlyco_trans_35

PYGL PYGM

6.87e-053902IPR000811
DomainIQ_motif_EF-hand-BS

MYH6 MYH7 MYO15B MYH7B MYO19

7.39e-0590905IPR000048
DomainMyosin_tail_1

MYH6 MYH7 MYH7B

8.38e-0518903PF01576
DomainMyosin_tail

MYH6 MYH7 MYH7B

8.38e-0518903IPR002928
DomainIQ

MYH6 MYH7 MYO15B MYH7B MYO19

8.64e-0593905PS50096
Domain-

FAT2 FAT3 LAMA3 WDFY3 USH2A

9.57e-05959052.60.120.200
DomainMyosin-like_IQ_dom

MYH6 MYH7 MYH7B

9.92e-0519903IPR027401
Domain-

MYH6 MYH7 MYH7B

9.92e-05199034.10.270.10
DomainEGF_1

NTN4 FAT2 FAT3 LAMA3 ASTN2 VWA2 USH2A

2.32e-04255907PS00022
DomainKinase-like_dom

MST1R FRK PLK2 TBK1 WDR81 DAPK1 PEAK1 MELK CDC42BPB ALPK2

2.78e-045429010IPR011009
DomainEGF_LAM_2

NTN4 LAMA3 USH2A

4.00e-0430903PS50027
DomainEGF_LAM_1

NTN4 LAMA3 USH2A

4.00e-0430903PS01248
DomainIQ

MYH6 MYH7 MYH7B MYO19

6.32e-0481904SM00015
DomainLaminin_EGF

NTN4 LAMA3 USH2A

6.33e-0435903PF00053
DomainEGF_Lam

NTN4 LAMA3 USH2A

6.33e-0435903SM00180
DomainConA-like_dom

FAT2 FAT3 LAMA3 COL14A1 WDFY3 USH2A

6.66e-04219906IPR013320
DomainP-loop_NTPase

MYH6 MYH7 RAB33A MYO15B TDRD9 ABCA12 MYH7B VPS4A MYO19 HELZ2 DAPK1 RAB33B

7.48e-048489012IPR027417
DomainLaminin_EGF

NTN4 LAMA3 USH2A

8.08e-0438903IPR002049
DomainBEACH_dom

WDR81 WDFY3

8.09e-049902IPR000409
DomainBEACH

WDR81 WDFY3

8.09e-049902PS50197
DomainBeach

WDR81 WDFY3

8.09e-049902PF02138
Domain-

WDR81 WDFY3

8.09e-0499021.10.1540.10
DomainBeach

WDR81 WDFY3

8.09e-049902SM01026
DomainAdipoR/HlyIII-related

ADIPOR1 MMD

1.23e-0311902IPR004254
DomainHlyIII

ADIPOR1 MMD

1.23e-0311902PF03006
DomainPROTEIN_KINASE_ATP

MST1R FRK PLK2 TBK1 DAPK1 PEAK1 MELK CDC42BPB

1.67e-03459908PS00107
DomainNCD3G

TAS1R3 TAS1R2

1.73e-0313902PF07562
DomainGPCR_3_9-Cys_dom

TAS1R3 TAS1R2

1.73e-0313902IPR011500
DomainGPCR_3_CS

TAS1R3 TAS1R2

2.01e-0314902IPR017979
DomainProtein_kinase_ATP_BS

MST1R FRK PLK2 TBK1 DAPK1 MELK CDC42BPB

2.37e-03379907IPR017441
DomainProt_kinase_dom

MST1R FRK PLK2 TBK1 DAPK1 PEAK1 MELK CDC42BPB

2.47e-03489908IPR000719
DomainPROTEIN_KINASE_DOM

MST1R FRK PLK2 TBK1 DAPK1 PEAK1 MELK CDC42BPB

2.60e-03493908PS50011
DomainCyclin_C

CCNJL CCNJ

2.98e-0317902PF02984
DomainCyclin_C-dom

CCNJL CCNJ

2.98e-0317902IPR004367
DomainCyclin_C

CCNJL CCNJ

2.98e-0317902SM01332
DomainGPCR_3

TAS1R3 TAS1R2

4.54e-0321902IPR000337
Domain7tm_3

TAS1R3 TAS1R2

4.98e-0322902PF00003
DomainG_PROTEIN_RECEP_F3_2

TAS1R3 TAS1R2

4.98e-0322902PS00980
DomainG_PROTEIN_RECEP_F3_3

TAS1R3 TAS1R2

4.98e-0322902PS00981
DomainG_PROTEIN_RECEP_F3_1

TAS1R3 TAS1R2

4.98e-0322902PS00979
DomainG_PROTEIN_RECEP_F3_4

TAS1R3 TAS1R2

4.98e-0322902PS50259
DomainGPCR_3_C

TAS1R3 TAS1R2

4.98e-0322902IPR017978
DomainHR1_rho-bd

RHPN1 TBC1D4

6.41e-0325902IPR011072
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK2 FAT2 MYO15B HELZ2 ANKRD26 ASTN2 PEAK1 CUL7 CDC42BPB KLHL18 ARHGEF15

8.90e-08493931115368895
Pubmed

The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.

MYH6 MYH7 THRA

3.01e-061193320739404
Pubmed

Association of sweet taste receptor gene polymorphisms with dental caries experience in school children.

TAS1R3 TAS1R2

7.07e-06293225924601
Pubmed

Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.

MYH6 MYH7

7.07e-06293221526716
Pubmed

Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.

MYH6 MYH7

7.07e-06293218480046
Pubmed

The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.

TAS1R3 TAS1R2

7.07e-06293212706725
Pubmed

Sweet taste receptor deficient mice have decreased adiposity and increased bone mass.

TAS1R3 TAS1R2

7.07e-06293224466105
Pubmed

Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy.

TAS1R3 TAS1R2

7.07e-06293219664591
Pubmed

Murine pulmonary myocardium: developmental analysis of cardiac gene expression.

MYH6 MYH7

7.07e-0629327919499
Pubmed

T1R2+T1R3-independent chemosensory inputs contributing to behavioral discrimination of sugars in mice.

TAS1R3 TAS1R2

7.07e-06293230624973
Pubmed

The importance of the presence of a 5'-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of L-glutamate as assessed psychophysically.

TAS1R3 TAS1R2

7.07e-06293225253867
Pubmed

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.

TAS1R3 TAS1R2

7.07e-06293230723160
Pubmed

T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in mice.

TAS1R3 TAS1R2

7.07e-06293219158407
Pubmed

Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias.

MYH6 MYH7

7.07e-06293234384224
Pubmed

Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity.

TAS1R3 TAS1R2

7.07e-06293226884387
Pubmed

Characterization of human cardiac myosin heavy chain genes.

MYH6 MYH7

7.07e-0629322726733
Pubmed

Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3.

TAS1R3 TAS1R2

7.07e-06293225029362
Pubmed

Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal.

TAS1R3 TAS1R2

7.07e-06293222621968
Pubmed

Micro and macro models of the sweet receptor.

TAS1R3 TAS1R2

7.07e-06293215738209
Pubmed

Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.

TAS1R3 TAS1R2

7.07e-06293237938171
Pubmed

Human cardiac myosin heavy chain gene mapped within chromosome region 14q11.2----q13.

MYH6 MYH7

7.07e-0629322494889
Pubmed

Human cardiac myosin heavy chain genes and their linkage in the genome.

MYH6 MYH7

7.07e-0629323037493
Pubmed

β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.

MYH6 MYH7

7.07e-06293221778428
Pubmed

Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6).

MYH6 MYH7

7.07e-0629328307559
Pubmed

Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer in a mouse model.

TAS1R3 TAS1R2

7.07e-06293221940444
Pubmed

Salivary leptin and TAS1R2/TAS1R3 polymorphisms are related to sweet taste sensitivity and carbohydrate intake from a buffet meal in healthy young adults.

TAS1R3 TAS1R2

7.07e-06293229110749
Pubmed

Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.

TAS1R3 TAS1R2

7.07e-06293232551626
Pubmed

A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae.

RAB33A RAB33B

7.07e-0629329512502
Pubmed

The anatomy of mammalian sweet taste receptors.

TAS1R3 TAS1R2

7.07e-06293227936499
Pubmed

Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli.

TAS1R3 TAS1R2

7.07e-06293216271873
Pubmed

Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1).

SLC9A1 THRA

7.07e-06293212039959
Pubmed

Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.

MYH6 MYH7

7.07e-0629322969919
Pubmed

All-atom molecular dynamics simulations of actin-myosin interactions: a comparative study of cardiac α myosin, β myosin, and fast skeletal muscle myosin.

MYH6 MYH7

7.07e-06293224224850
Pubmed

Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.

MYH6 MYH7

7.07e-06293217575272
Pubmed

Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.

MYH6 MYH7

7.07e-06293216088376
Pubmed

Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.

TAS1R3 TAS1R2

7.07e-06293220302879
Pubmed

Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences.

MYH6 MYH7

7.07e-0629321776652
Pubmed

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.

MYH6 MYH7

7.07e-0629329884344
Pubmed

Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes.

MYH6 MYH7

7.07e-06293212750067
Pubmed

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.

SGMS1 SAMD8

7.07e-06293219506037
Pubmed

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

TAS1R3 TAS1R2

7.07e-06293217935609
Pubmed

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.

MYH6 MYH7

7.07e-0629329541509
Pubmed

A TAS1R receptor-based explanation of sweet 'water-taste'.

TAS1R3 TAS1R2

7.07e-06293216633339
Pubmed

Detection of maltodextrin and its discrimination from sucrose are independent of the T1R2 + T1R3 heterodimer.

TAS1R3 TAS1R2

7.07e-06293228768658
Pubmed

Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.

TAS1R3 TAS1R2

7.07e-06293231553164
Pubmed

Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

MYH6 MYH7

7.07e-06293223580644
Pubmed

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

TAS1R3 TAS1R2

7.07e-06293226157055
Pubmed

β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.

MYH6 MYH7

7.07e-06293224829265
Pubmed

Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.

TAS1R3 TAS1R2

7.07e-06293228228527
Pubmed

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.

MYH6 MYH7

7.07e-0629322036722
Pubmed

Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.

TAS1R3 TAS1R2

7.07e-06293232607758
Pubmed

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.

MYH6 MYH7

7.07e-06293225937279
Pubmed

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.

TAS1R3 TAS1R2

7.07e-06293227162343
Pubmed

The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.

TAS1R3 TAS1R2

7.07e-06293221540445
Pubmed

Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption.

TAS1R3 TAS1R2

7.07e-06293229019082
Pubmed

Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.

MYH6 MYH7

7.07e-06293215621050
Pubmed

Neural Isolation of the Olfactory Bulbs Severely Impairs Taste-Guided Behavior to Normally Preferred, But Not Avoided, Stimuli.

TAS1R3 TAS1R2

7.07e-06293232152061
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

MYH7 TBC1D4 MAN2A2 THRA TBK1 ANKRD26 COL14A1 PYGM CDC42BPB

7.69e-0649793923414517
Pubmed

Essential role of MESP1-RING1A complex in cardiac differentiation.

MYH6 MYH7 CTCF

8.23e-061593336413948
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZZZ3 THRA CTCF ABCA12 VPS4A FAT3 TBK1 CEP295 WDFY3 PLD1 LBR CUL7 LYAR

8.60e-061116931331753913
Pubmed

A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.

MYH6 MYH7 MYH7B

1.01e-051693319922871
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

PWP1 USP10 MYADM MAN2A2 CTCF TBK1 UGGT1 HELZ2 CPSF1 COL14A1 PLD1 LBR LYAR CDC42BPB

1.65e-051371931436244648
Pubmed

Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease.

SGMS1 SAMD8

2.12e-05393237586586
Pubmed

Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus.

MYH6 MYH7

2.12e-0539328620598
Pubmed

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.

MYH6 MYH7

2.12e-05393218362229
Pubmed

Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.

MYH6 MYH7

2.12e-0539321939265
Pubmed

The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.

TAS1R3 TAS1R2

2.12e-05393229277113
Pubmed

The receptors for mammalian sweet and umami taste.

TAS1R3 TAS1R2

2.12e-05393214636554
Pubmed

Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.

MYH6 MYH7

2.12e-05393220923879
Pubmed

Three sweet receptor genes are clustered in human chromosome 1.

TAS1R3 TAS1R2

2.12e-05393212856281
Pubmed

Molecular genetic identification of a candidate receptor gene for sweet taste.

TAS1R3 TAS1R2

2.12e-05393211322794
Pubmed

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

MYH6 MYH7

2.12e-0539321694848
Pubmed

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.

FAT2 FAT3

2.12e-05393215744052
Pubmed

Amino acid taste receptor regulates insulin secretion in pancreatic β-cell line MIN6 cells.

TAS1R3 TAS1R2

2.12e-05393221470345
Pubmed

Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.

TAS1R3 TAS1R2

2.12e-05393224068707
Pubmed

Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.

TAS1R3 TAS1R2

2.12e-05393233654187
Pubmed

REEP2 enhances sweet receptor function by recruitment to lipid rafts.

TAS1R3 TAS1R2

2.12e-05393220943918
Pubmed

Phosphorus Taste Involves T1R2 and T1R3.

TAS1R3 TAS1R2

2.12e-05393228383662
Pubmed

Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.

MYH6 MYH7

2.12e-05393218755891
Pubmed

All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.

SGMS1 SAMD8

2.12e-05393225605874
Pubmed

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.

TAS1R3 TAS1R2

2.12e-05393228361903
Pubmed

An amino-acid taste receptor.

TAS1R3 TAS1R2

2.12e-05393211894099
Pubmed

Identification of a family of animal sphingomyelin synthases.

SGMS1 SAMD8

2.12e-05393214685263
Pubmed

Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.

SGMS1 SAMD8

2.12e-05393237166445
Pubmed

Mutation in myosin heavy chain 6 causes atrial septal defect.

MYH6 MYH7

2.12e-05393215735645
Pubmed

Mammalian sweet taste receptors.

TAS1R3 TAS1R2

2.12e-05393211509186
Pubmed

Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.

TAS1R3 TAS1R2

2.12e-05393229443544
Pubmed

Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.

TAS1R3 TAS1R2

2.12e-05393212892531
Pubmed

The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoform.

MYH6 MYH7

2.12e-05393222966157
Pubmed

Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest.

MYH6 MYH7

2.12e-05393211066038
Pubmed

Taste information derived from T1R-expressing taste cells in mice.

TAS1R3 TAS1R2

2.12e-05393226912569
Pubmed

The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart.

MYH6 MYH7 CUL7

2.75e-052293336877136
Pubmed

Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

PWP1 USP10 CTCF VPS4A HELZ2 LYAR

3.52e-0522893630471916
Pubmed

WD40 repeat and FYVE domain containing 3 is essential for cardiac development.

MYH6 MYH7 WDFY3

4.08e-052593330428088
Pubmed

Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.

MYH6 MYH7

4.23e-0549329927321
Pubmed

Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.

MYH6 MYH7

4.23e-05493225900833
Pubmed

Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development.

MYH6 MYH7

4.23e-0549328482409
Pubmed

Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.

MYH7 MYH7B

4.23e-05493219948655
Pubmed

Human receptors for sweet and umami taste.

TAS1R3 TAS1R2

4.23e-05493211917125
Pubmed

Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.

TAS1R3 TAS1R2

4.23e-05493220876097
InteractionLZTR1 interactions

MYH6 MYH7 ZZZ3 VPS4A PYGM WDFY3

1.04e-05111906int:LZTR1
Cytoband6p21.1

UBR2 TMEM151B CUL7

5.91e-04809336p21.1
GeneFamilyMyosin heavy chains

MYH6 MYH7 MYH7B

1.96e-05156531098
GeneFamilyTaste 1 receptors

TAS1R3 TAS1R2

3.81e-0536521161
GeneFamilyGlycogen phosphorylases

PYGL PYGM

3.81e-053652437
GeneFamilyWD repeat domain containing|BEACH domain containing

WDR81 WDFY3

4.51e-0496521230
GeneFamilyProgestin and adipoQ receptor family

ADIPOR1 MMD

6.85e-0411652930
GeneFamilyCadherin related

FAT2 FAT3

1.67e-031765224
GeneFamilyNeuroblastoma breakpoint family

NBPF15 NBPF10

3.07e-0323652662
GeneFamilyCyclins

CCNJL CCNJ

4.53e-0328652473
GeneFamilyTudor domain containing

TDRD9 LBR

7.82e-0337652780
GeneFamilyKelch like|BTB domain containing

KLHL11 KLHL18

9.99e-0342652617
GeneFamilyWD repeat domain containing

PWP1 GTF3C2 WDR81 WDFY3

1.46e-02262654362
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 FAT3 DAPK1 ASTN2 WDFY3

2.23e-06183926738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 FAT3 DAPK1 ASTN2 WDFY3

2.23e-0618392692fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 MAL TBC1D4 DAPK1 ASTN2 COL14A1

2.30e-06184926d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 DAPK1 ASTN2 WDFY3 ALPK2

2.44e-061869265c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MST1R MAL LAMA3 DAPK1 ASTN2 COL14A1

2.52e-0618792687b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MST1R MAL LAMA3 DAPK1 ASTN2 COL14A1

2.52e-0618792642a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MST1R MAL LAMA3 DAPK1 ASTN2 COL14A1

2.52e-0618792664afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 FAT3 DAPK1 ASTN2 WDFY3

2.68e-06189926904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 LAMA3 DAPK1 ASTN2 SIM1

3.12e-06194926e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRK NTN4 MAL FAT3 DAPK1 SIM1

3.31e-06196926c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RHPN1 KIAA0825 ANKRD26 CEP295 MELK

1.87e-05157925410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf|Thalamus / BrainAtlas - Mouse McCarroll V32

FAT2 MAL ACTL9 DCST1

2.08e-05789245b45aacaff2a2b98c4ef8e7ac51ad482a69a1d8b
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)|Thalamus / BrainAtlas - Mouse McCarroll V32

FAT2 MAL ACTL9 DCST1

2.08e-0578924afed2f358c8a33889931bc5ad8cb24f92323e6f8
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAL MYH7B TAS1R3 FAT3 ITPR2

2.11e-05161925f5df8c6a340d5026726804b103e32137f363ca40
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCNJL NTN4 DAPK1 ASTN2 COL14A1

2.30e-05164925382e42701779d12a7948690b3be72d06dd75c8b4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 DAPK1 ASTN2 LBR ALPK2

3.14e-05175925284fdc7a9d303636a637041846850d19d114861a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 DAPK1 ASTN2 LBR

3.69e-051819256a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCellCOVID-19-Epithelial-Ionocytes|Epithelial / Condition, Lineage and Cell class

MAL TBC1D4 ANKRD9 PYGM ITPR2

3.69e-051819254a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D4 FAT3 DAPK1 ASTN2 WDFY3

3.69e-05181925071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPTLC3 MAL TBC1D4 ASTN2 SIM1

3.79e-05182925ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC9A1 GTF3C2 ANKRD26 E2F6 CRAT

4.31e-05187925c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SLC9A1 GTF3C2 ANKRD26 E2F6 CRAT

4.54e-0518992599b01893da9f9f7c9528afaffad178285211738b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MST1R MAL DAPK1 ASTN2 VWA2

4.54e-05189925aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D4 DAPK1 ASTN2 WDFY3 SIM1

4.54e-05189925830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MST1R MAL DAPK1 ASTN2 VWA2

4.54e-051899258977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 SGMS1 DAPK1 ASTN2 COL14A1

4.65e-05190925bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 SGMS1 DAPK1 ASTN2 COL14A1

4.65e-05190925b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCellkidney_cells-Adult_normal_reference-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 PTPN7 RAB33A LYAR MELK

4.65e-05190925b65383e256b04122500b742caeed0b807793851e
ToppCellkidney_cells-Adult_normal_reference-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 PTPN7 RAB33A LYAR MELK

4.65e-0519092589095d3e023269d89c82e3a73550f869e3f34201
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

MYH6 MYH7 TBC1D4 MYH7B ALPK2

4.65e-05190925fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 SGMS1 DAPK1 ASTN2 COL14A1

4.77e-051919252fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPTLC3 MAL DAPK1 ASTN2 SIM1

4.77e-05191925fe55475ce0666ab5122447a813dc2369e24947b8
ToppCelldroplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 TBC1D4 PYGM ALPK2

4.77e-0519192597fb4232417a39801e87725755fd16a57c250209
ToppCelldroplet-Heart-nan-3m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 TBC1D4 PYGM ALPK2

4.77e-0519192564070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

MYH6 MYH7 TBC1D4 MYH7B ALPK2

4.89e-05192925ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 MAL LAMA3 DAPK1 ASTN2

5.01e-05193925f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 MAL LAMA3 DAPK1 ASTN2

5.01e-0519392542df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 TBC1D4 DAPK1 WDFY3 ALPK2

5.14e-051949258ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

MYH6 TBC1D4 MYH7B ASTN2 ALPK2

5.14e-05194925c3535f7cc0076653c72db582047cff053c322397
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 TBC1D4 MYH7B ALPK2

5.26e-0519592575fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYO15B NBPF10 LAMA3 ALDOB ITPR2

5.26e-05195925e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 MAL DAPK1 ASTN2 SIM1

5.39e-051969256ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRK MAL DAPK1 ASTN2 SIM1

5.39e-05196925eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellsevere-Myeloid-Neutrophils_4|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

MYADM ADIPOR1 TDRD9 PYGL WDFY3

5.79e-0519992550242666def13e5d4149c563ae000d6768f086f7
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NTN4 TDRD9 TAS1R2 LAMA3

6.20e-05103924c11bb0238e81a42dad5d7687c9d22474129d803d
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYADM TAS1R2 LAMA3 CRAT

8.01e-05110924c80d1c3df75648e2c8f6832279c2acca63d76681
Drugamorphin

PYGL PYGM ALDOB

3.52e-068923CID000122792
DrugLaevuflex

FRK MYH6 MYH7 SLC9A1 PYGL PYGM ALDOB CRAT

1.46e-05272928CID000003426
Drugpaclitaxel; Up 200; 0.1uM; MCF7; HG-U133A

MST1R TBC1D4 ANKRD26 LBR KLHL18 ARHGEF15 RAB33B

1.59e-05198927640_UP
Drug1,6-dichlorosucrose

TAS1R3 TAS1R2

1.62e-052922ctd:C039464
Drug1-chlorosucrose

TAS1R3 TAS1R2

1.62e-052922ctd:C039463
Drug1-N-Acetyl-Beta-D-Glucosamine

PYGL PYGM

1.62e-052922DB02320
Drugneotame

TAS1R3 TAS1R2

1.62e-052922ctd:C404525
Drug3,5-dimethylphenyl isocyanate

PYGL PYGM

4.83e-053922CID000521488
Drug5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone

PYGL PYGM

4.83e-053922CID000093111
Drugadenosine-5'-chloromethylphosphonate

PYGL PYGM

4.83e-053922CID000191554
Drugtrichlorosucrose

TAS1R3 TAS1R2

4.83e-053922ctd:C026285
Drughydan

PYGL PYGM

4.83e-053922CID000008360
DrugEHMF

PYGL PYGM

4.83e-053922CID000033931
Drug5'-deoxy-5'-fluoro-5'-(methylthio)adenosine

PYGL PYGM

4.83e-053922CID000147839
Drugpyridoxal 5'-methylenephosphonate

PYGL PYGM

4.83e-053922CID003082249
DrugPlp 5'-mpa

PYGL PYGM

4.83e-053922CID003082151
Drugglucose-1,2-cyclic phosphate

PYGL PYGM

4.83e-053922CID000191723
Drug3'-FFdUrd

PYGL PYGM

4.83e-053922CID000072260
Drug2',3',4',5,5'-pentachloro-2-biphenylol

PYGL PYGM

4.83e-053922CID000119518
DrugAC1L8XK3

PYGL PYGM

4.83e-053922CID000409735
DrugN-acetyl-N'-beta-D-glucopyranosyl urea

PYGL PYGM

4.83e-053922CID000446801
DrugNSC758405

PYGL PYGM

4.83e-053922CID000003201
Drug3,5-dinitrophenyl phosphate

PYGL PYGM

4.83e-053922CID000151920
Drugriboflavin tetraacetate

PYGL PYGM

4.83e-053922CID000094186
Drugpyridoxal phosphoglucose

PYGL PYGM

4.83e-053922CID000196007
DrugCyclamates

TAS1R3 TAS1R2

4.83e-053922ctd:D003494
Drug2,5-dimethyl-3-furanone

PYGL PYGM

4.83e-053922CID000085730
Drug3,5-dinitrophenol

PYGL PYGM

4.83e-053922CID000011459
DrugADP alpha S

PYGL PYGM CRAT

5.90e-0519923CID000171069
Druggalocitabine

PYGL PYGM

9.64e-054922CID000065950
Drug2,5-anhydro-D-mannitol 1-phosphate

PYGL PYGM

9.64e-054922CID000189134
DrugAC1LAMW2

PYGL PYGM

9.64e-054922CID000491364
DrugFdUrd-C8

PYGL PYGM

9.64e-054922CID000094262
DrugMem-CC

PYGL PYGM

9.64e-054922CID003081269
Drug5-deoxyribose-1-phosphate

PYGL PYGM

9.64e-054922CID000135786
Drugingliforib

PYGL PYGM

9.64e-054922CID006451325
Druguric acid riboside

PYGL PYGM

9.64e-054922CID000164933
Drugpseudo-dl-glucose

PYGL PYGM

9.64e-054922CID000125259
Drug4-carb-oxy-butano-ate

ESD MMD

9.64e-054922CID000073917
DrugBCIp4A

PYGL PYGM

9.64e-054922CID000192417
Drugpyridoxal diphosphate

PYGL PYGM

9.64e-054922CID000125696
Drug3'-chloromethotrexate

PYGL PYGM

9.64e-054922CID000097703
Drugdihydrolipoamide

LIPT1 TBK1 PYGL PYGM PLD1

1.23e-04119925CID000000663
DrugIodixanol [92339-11-2]; Up 200; 2.6uM; MCF7; HT_HG-U133A

MST1R THRA PEAK1 CUL7 ENTPD4 ITPR2

1.50e-041979263362_UP
DrugTranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; MCF7; HT_HG-U133A

MYH7 RAB33A ANKRD26 PLD1 PEAK1 CUL7

1.54e-041989265996_UP
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; PC3; HT_HG-U133A

SPTLC3 ANKRD26 WDFY3 CUL7 ENTPD4 ITPR2

1.54e-041989263756_DN
Drugheptulose-2-P

PYGL PYGM

1.60e-045922CID000124823
Drugm-anisidine

PYGL PYGM

1.60e-045922CID000010824
Drug6-FPLP

PYGL PYGM

1.60e-045922CID000146246
Druggluconohydroximo-1,5-lactone

PYGL PYGM

1.60e-045922CID009576855
Drug2-hydroxypropylphosphonate

PYGL PYGM

1.60e-045922CID000441028
DrugDHPBU

PYGL PYGM

1.60e-045922CID000125914
Drug6-FDPL

PYGL PYGM

1.60e-045922CID000129578
Drugdimethylglutarate

ESD MMD

1.60e-045922CID000014242
Drug5'-isobutylthioinosine

PYGL PYGM

1.60e-045922CID003080910
Drug3'-O-methylpyridoxal 5'-phosphate

PYGL PYGM

1.60e-045922CID003082179
DrugGlcMan

PYGL PYGM

1.60e-045922CID000152120
DrugU66985

PYGL PYGM

1.60e-045922CID000127224
Drugindirubin-5-sulphonate

PYGL PYGM

1.60e-045922CID005288641
DrugAC1O3M08

PYGL PYGM

1.60e-045922CID006331955
DrugAC1LCUXJ

PYGL PYGM

1.60e-045922CID000656425
Drug6-amino-5-bromouracil

PYGL PYGM

1.60e-045922CID000080578
Drugetafenone

PYGL PYGM

1.60e-045922CID000003275
DrugddEtUrd

PYGL PYGM

1.60e-045922CID000451452
Drug5-trifluoromethyl-2'-deoxycytidine

PYGL PYGM

1.60e-045922CID000125618
DrugdiHPA

MYH6 THRA

1.60e-045922CID000151819
Drug1-o-phosphonohex-2-ulose

PYGL PYGM ALDOB

2.16e-0429923CID000000481
DrugCV-araU

PYGL PYGM

2.40e-046922CID006441877
Drug2-thiothymidine

PYGL PYGM

2.40e-046922CID003005944
DrugGC 1 compound

MYH6 MYH7

2.40e-046922ctd:C413355
DrugCarbocyclic Bvdc

PYGL PYGM

2.40e-046922CID006438602
DrugDNPP

PYGL PYGM

2.40e-046922CID000067056
Drug5-chloro-indole-2-carboxylic acid

PYGL PYGM

2.40e-046922CID000082693
Drug2,2-dimethyl-3-hydroxybutyric acid

PYGL PYGM

2.40e-046922CID000152984
Druglactisole

TAS1R3 TAS1R2

2.40e-046922ctd:C495512
DrugEdUMP

PYGL PYGM

2.40e-046922CID003085112
Drug4-hydroxyacetophenone

PYGL PYGM

2.40e-046922ctd:C031335
Drug5'-deoxy-5'-chloroformycin

PYGL PYGM

2.40e-046922CID000126430
DrugNSC-97433

PYGL PYGM

2.40e-046922CID000001803
Drug5-n-propylthioadenosine

PYGL PYGM

2.40e-046922CID000656428
DrugAzddCyd

PYGL PYGM

2.40e-046922CID000451374
Drug5-Ffdru

PYGL PYGM

2.40e-046922CID000065561
DrugAR-L57

PYGL PYGM

2.40e-046922CID000156890
Drugtegaserod

THRA HTR4

2.40e-046922ctd:C105050
DrugCarbocyclic Ivdu

PYGL PYGM

2.40e-046922CID006439191
Drug2,5-anhydro-D-mannitol

PYGL PYGM CRAT

2.64e-0431923CID000001494
DrugAC1L9I7L

ESD PYGL PYGM MMD

2.98e-0479924CID000445564
Drugalpha-(fluoromethyl)dehydroornithine

PYGL PYGM

3.35e-047922CID006439607
Drug6-fluoropyridoxal

PYGL PYGM

3.35e-047922CID003080803
Drug2',3'-dideoxy-3'-fluorocytidine

PYGL PYGM

3.35e-047922CID000356019
Drugheptenitol

PYGL PYGM

3.35e-047922CID000188267
DrugAC1L3372

PYGL PYGM

3.35e-047922CID000108025
Drug1 Gpt

PYGL PYGM

3.35e-047922CID000101247
Drugformycins

PYGL PYGM

3.35e-047922CID000512867
DrugPromonta

PYGL PYGM

3.35e-047922CID000108494
Drug5'-methylthioinosine

PYGL PYGM

3.35e-047922CID000161214
Drughydantocidin

PYGL PYGM

3.35e-047922CID000125429
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0110454 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0111269 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0080719 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0111602 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0080326 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH6 MYH7 MYH7B

3.24e-0610903DOID:0111596 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

5.92e-0612903DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH6 MYH7 MYH7B

5.92e-0612903DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

7.68e-0613903DOID:397 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH6 MYH7 MYH7B

1.22e-0515903DOID:0050646 (implicated_via_orthology)
DiseaseCaveolinopathy

MYH6 MYH7

5.50e-054902cv:C5679790
DiseaseCARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1

MYH6 MYH7

5.50e-054902192600
DiseaseCardiomyopathy, Familial Hypertrophic, 1 (disorder)

MYH6 MYH7

5.50e-054902C3495498
DiseaseHypertrophic cardiomyopathy 1

MYH6 MYH7

5.50e-054902cv:C3495498
DiseaseHypertrophic obstructive cardiomyopathy

MYH6 MYH7 SLC9A1

6.01e-0525903C4551472
DiseaseIdiopathic hypertrophic subaortic stenosis

MYH6 MYH7

1.91e-047902C0700053
DiseaseObstructive asymmetric septal hypertrophy

MYH6 MYH7

1.91e-047902C0597124
DiseaseCardiomyopathy, Hypertrophic, Familial

MYH6 MYH7

3.27e-049902C0949658
DiseaseMuscular dystrophy, limb-girdle, autosomal dominant

MYH6 MYH7

4.07e-0410902cv:C5675009
Diseasemyopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

4.30e-0448903DOID:423 (implicated_via_orthology)
Diseasefactor VII activating protease measurement

USP10 HELZ2 MELK

6.42e-0455903EFO_0009368
DiseaseHypertrophic Cardiomyopathy

MYH6 MYH7 SLC9A1

7.13e-0457903C0007194
Diseasetrimethylamine-N-oxide measurement

TAS1R2 ITPR2

8.17e-0414902EFO_0010541
DiseaseLeft ventricular noncompaction

MYH7 MYH7B

8.17e-0414902C1960469
Diseasecardiomyopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

1.35e-0371903DOID:0050700 (implicated_via_orthology)
Diseasehypothyroidism (biomarker_via_orthology)

MYH6 MYH7 SLC9A1

1.90e-0380903DOID:1459 (biomarker_via_orthology)
Diseasedilated cardiomyopathy (implicated_via_orthology)

MYH6 MYH7 MYH7B

1.90e-0380903DOID:12930 (implicated_via_orthology)
Diseasehypertrophic cardiomyopathy (is_implicated_in)

MYH7 MYH7B

2.04e-0322902DOID:11984 (is_implicated_in)
DiseasePrimary familial hypertrophic cardiomyopathy

MYH6 MYH7

2.04e-0322902cv:C0949658
DiseaseLimb-girdle muscular dystrophy

MYH6 MYH7

2.85e-0326902cv:C0686353
Diseaseurate measurement, bone density

SPTLC3 HELZ2 PEAK1 SIM1 USH2A ENTPD4 ITPR2

2.88e-03619907EFO_0003923, EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
QLTTDFVHHYIVANY

BHLHB9

431

Q6PI77
FVHHYIVANYFSELF

BHLHB9

436

Q6PI77
SYYFIATFITDHIRH

ESD

261

P10768
GVYYLHSLQIAHFDL

DAPK1

126

P53355
YCDAVFHERYALIQH

CTCF

471

P49711
YEFFENQYIHVLHLS

ALPK2

61

Q86TB3
AAVYKALNDHHVYLE

ALDOB

211

P05062
VTVEEHLYFYARVHG

ABCA12

2346

Q86UK0
VENIKHHYCYVASDF

ACTL9

251

Q8TC94
EYAHYFLEVTLQDHI

CCNJL

231

Q8IV13
TAAHFIEYYLSEAVH

CCNJ

146

Q5T5M9
FHAEIYFDHDLQSYV

AGGF1

456

Q8N302
VHNYQFFELDVYHSD

CRAT

206

P43155
VHAHAVGPFSVYVDY

ARHGEF15

496

O94989
LADVHGNTALHYAVY

ANKRD26

141

Q9UPS8
EELLSFIQHYGSHYI

ASTN2

891

O75129
SMVEHYYRNVHAVVF

RAB33A

101

Q14088
QHYYRNVHAVVFVYD

RAB33B

101

Q9H082
ANQDDYISFRHHVYK

IMP4

221

Q96G21
TAEQYQFLHHTLALY

PTPN7

336

P35236
YYANHTAQIEIVRHD

ITPR2

2141

Q14571
TSLFQGVEFHYVYSH

LBR

311

Q14739
HFSLIHYAGIVDYNI

MYH7

576

P12883
IVSAVAYVHSQGYAH

MELK

116

Q14680
HVLVVAAAFVHFYGV

ADIPOR1

341

Q96A54
KFYHDFHSEIFQYTV

KIAA0100

1081

Q14667
RYVFVIHFYQAAHPT

LAMA3

1126

Q16787
NLHTYLSTAVYVFQH

KIAA0825

546

Q8IV33
HFVAHYLRAQQEEYA

MYO19

441

Q96H55
VATEYAAYHQIDNHI

LIPT1

231

Q9Y234
HYLHQANYSIIDDAT

KIAA1109

2111

Q2LD37
TAHYVAYHVESKVYA

CPSF1

1021

Q10570
AHFEVVHYAGVVPYS

MYH7B

621

A7E2Y1
ETCQTYHFHVVAYDH

FAT2

2866

Q9NYQ8
YHFHVVAYDHGQTIQ

FAT2

2871

Q9NYQ8
YYHSLAVRQSLAVHF

PEAK1

1371

Q9H792
SGLEIATTFEHYYQH

CUL7

1256

Q14999
FVYATLQTAHYHRDA

CES4A

426

Q5XG92
AYVADLVHSAHLVFV

MYADM

306

Q96S97
ITALHYAFQDENHLY

CDC42BPB

136

Q9Y5S2
CHVTHVLPNVYYEFF

OOSP1

61

A8MZH6
YEHAANCYTHAFLIV

MMD

26

Q15546
FTVRHYAGTVTYQVH

MYO15B

146

Q96JP2
QRHGHYFVALFDYQA

FRK

41

P42685
HLDGHAVAVTESYVY

KLHL11

396

Q9NVR0
YDAANSFIHQHFVEV

KLHL18

156

O94889
AYVTYQDIHSIQAFH

E2F6

181

O75461
LSYQDAAFTYHHIQE

DOCK2

896

Q92608
YSIFDTIRHHSFLQY

DCST1

481

Q5T197
TEYQIAVFAIYAHTA

COL14A1

416

Q05707
FHFTHSIYNATVYEN

FAT3

41

Q8TDW7
AYYRIYVTAKEHAHQ

HTR4

211

Q13639
VHDHQAYAHYLLATF

ANKRD9

81

Q96BM1
GFTYRHYHENIAAVV

MAL

116

P21145
HYHENIAAVVFSYIA

MAL

121

P21145
FSEVVAYYEHIHQAV

MAN2A2

841

P49641
VLAQYYTVTDEHHRS

LYAR

336

Q9NX58
VLHDTYYVVAHFHYV

MT-CO1

366

P00395
NSAADIYIREYFHSH

HELZ2

576

Q9BYK8
NHAVLSYAVEEEHAY

CEP295

1926

Q9C0D2
RFHFHGQYYTTETAV

USH2A

486

O75445
VLAEYRTAYAHYHVE

TMEM151B

316

Q8IW70
AHEHYSIDVFIAFYI

SAMD8

341

Q96LT4
FSVVHSVLHVDVYQY

TDRD9

1051

Q8NDG6
QHFTHYAIYDFIVKG

NTN4

246

Q9HB63
QHYRSVFYSFEEQHI

NBPF10

3751

Q6P3W6
QHYRSVFYSFEEEHI

NBPF15

626

Q8N660
YVHVIENSRHYIYIE

PLD1

766

Q13393
VHQTEHVYRVYVATF

ENTPD4

311

Q9Y227
TAHQPYHSHFVQEYE

SIM1

141

P81133
YHSHFVQEYEIERSF

SIM1

146

P81133
LVDYLRVHSHSAVYA

SPTLC3

386

Q9NUV7
AHFSLIHYAGTVDYN

MYH6

576

P13533
VKAEYFRSLAHYHVA

RHPN1

346

Q8TCX5
LSYVHVTVDTYSHFI

ERVK-25

661

P63136
YVNVYGTHVLVSAAH

TGDS

116

O95455
VHVYNQEEDSFYVHH

PWP1

166

Q13610
NHHQTFSVYAAVYSV

TAS1R3

386

Q7RTX0
FSVYAAVYSVAQALH

TAS1R3

391

Q7RTX0
FHHLFYEGQVDIYNI

WDFY3

2931

Q8IZQ1
DYYFALAHTVRDHLV

PYGM

51

P11217
VQVQHLSYNYSAFHF

SERINC4

416

A6NH21
ATVFHAYYLSAVANA

TERB2

61

Q8NHR7
IHVAAYADLRYHQDV

VWA2

686

Q5GFL6
YYSSFIIHQRVHTGE

ZNF211

296

Q13398
VVLYHLFEEFANYEH

SLC9A1

271

P19634
HDHYTVDVVVAYYIT

SGMS1

326

Q86VZ5
HNSHDLTYFAYLIKA

TBC1D4

131

O60343
YSVYSAVYAVAHALH

TAS1R2

386

Q8TE23
TYRLFAVVYHHGNSA

USP10

731

Q14694
TYTETVNHHYLLFQD

GTF3C2

786

Q8WUA4
SQEAYLLAFEHYVNH

THRA

341

P10827
VFLSHYYLHVRADLQ

PIEZO1

1301

Q92508
HVVQFYHYFEDKENI

PLK2

141

Q9NYY3
ATDLTREVYQHLAHY

UBR2

31

Q8IWV8
DYYFALAHTVRDHLV

PYGL

51

P06737
DVYYFESDHVALKHN

ZZZ3

486

Q8IYH5
SIEYVHSFHTGAFVY

MST1R

246

Q04912
LYVVHPYVQFSLHDV

WDR81

231

Q562E7
EVDDYHAFQTLTHIY

UGGT1

561

Q9NYU2
IHSYNTATIFHELVY

TBK1

326

Q9UHD2
VEYFLHAIKYEAHSD

VPS4A

36

Q9UN37