Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RGPD3 RGPD1	1.74e-05	20	51	3	GO:0061665
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD4 RGPD3 RGPD1	1.06e-04	36	51	3	GO:0019789
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RGPD4 RGPD3 RGPD1	2.83e-04	50	51	3	GO:0003755
GeneOntologyMolecularFunction	cis-trans isomerase activity	RGPD4 RGPD3 RGPD1	3.36e-04	53	51	3	GO:0016859
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RGPD3 RGPD1	1.05e-06	9	49	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RGPD3 RGPD1	1.49e-06	10	49	3	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD4 RGPD3 RGPD1	3.54e-06	13	49	3	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD4 RGPD3 RGPD1	4.50e-06	14	49	3	GO:1903299
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 RGPD3 RGPD1	1.40e-05	20	49	3	GO:0006607
GeneOntologyBiologicalProcess	protein peptidyl-prolyl isomerization	RGPD4 RGPD3 RGPD1	1.00e-04	38	49	3	GO:0000413
GeneOntologyBiologicalProcess	forebrain neuron fate commitment	NKX2-1 LHX6	1.97e-04	9	49	2	GO:0021877
GeneOntologyBiologicalProcess	positive regulation of hepatic stellate cell activation	RPS6KA1 MYB	2.46e-04	10	49	2	GO:2000491
GeneOntologyBiologicalProcess	peptidyl-proline modification	RGPD4 RGPD3 RGPD1	2.87e-04	54	49	3	GO:0018208
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron differentiation	NKX2-1 LHX6	3.00e-04	11	49	2	GO:0021892
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD3 RGPD1	8.06e-07	8	52	3	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD3 RGPD1	1.72e-06	10	52	3	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD3 RGPD1	5.18e-06	14	52	3	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RGPD3 RGPD1	1.15e-05	18	52	3	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RGPD3 RGPD1	1.61e-05	20	52	3	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RGPD3 RGPD1	1.87e-05	21	52	3	GO:0106068
GeneOntologyCellularComponent	nuclear pore	RGPD4 IPO7 RGPD3 RGPD1	1.16e-04	101	52	4	GO:0005643
GeneOntologyCellularComponent	inclusion body	RGPD4 RGPD3 RGPD1	1.46e-03	90	52	3	GO:0016234
MousePheno	enlarged epididymis	KCNK18 RGPD4 RGPD3 RGPD1 KATNIP	5.86e-06	99	37	5	MP:0004931
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD4 RGPD3 RGPD1	9.34e-06	16	37	3	MP:0003701
MousePheno	abnormal morula morphology	RGPD4 RGPD3 RGPD1	4.26e-05	26	37	3	MP:0012058
MousePheno	decreased tumor latency	RGPD4 RGPD3 RGPD1	6.60e-05	30	37	3	MP:0010308
MousePheno	abnormal epididymis size	KCNK18 RGPD4 RGPD3 RGPD1 KATNIP	7.13e-05	166	37	5	MP:0004926
MousePheno	failure of blastocyst formation	RGPD4 RGPD3 RGPD1	7.29e-05	31	37	3	MP:0012129
MousePheno	abnormal tumor latency	RGPD4 RGPD3 RGPD1	9.65e-05	34	37	3	MP:0010307
MousePheno	increased myelin sheath thickness	CFAP276 KEL	1.02e-04	6	37	2	MP:0011730
MousePheno	abnormal internode morphology	CFAP276 KEL	1.42e-04	7	37	2	MP:0010738
MousePheno	abnormal blastocyst formation	RGPD4 RGPD3 RGPD1	1.46e-04	39	37	3	MP:0012128
MousePheno	abnormal male genitalia morphology	KCNK18 RGPD4 INSL6 NKX2-1 ABCA13 FBXW12 RGPD3 APAF1 RGPD1 KATNIP IP6K1 FOXP3	1.84e-04	1415	37	12	MP:0009198
MousePheno	abnormal male reproductive system morphology	KCNK18 RGPD4 INSL6 NKX2-1 ABCA13 FBXW12 RGPD3 APAF1 RGPD1 KATNIP IP6K1 FOXP3	1.84e-04	1415	37	12	MP:0001145
MousePheno	hydrocephaly	TRABD2B FBXW12 APAF1 KATNIP APOB	2.10e-04	209	37	5	MP:0001891
MousePheno	abnormal rod electrophysiology	RGPD4 RGPD3 RGPD1 METTL23	2.65e-04	119	37	4	MP:0004021
MousePheno	abnormal endocytosis	ABCA13 IP6K1	3.03e-04	10	37	2	MP:0030951
MousePheno	abnormal frontonasal prominence morphology	APAF1 MED23	5.22e-04	13	37	2	MP:0009901
MousePheno	aneuploidy	RGPD4 RGPD3 RGPD1	5.53e-04	61	37	3	MP:0004024
MousePheno	abnormal epididymis morphology	KCNK18 RGPD4 RGPD3 RGPD1 KATNIP	6.69e-04	269	37	5	MP:0002631
MousePheno	abnormal internal male genitalia morphology	KCNK18 RGPD4 INSL6 NKX2-1 FBXW12 RGPD3 APAF1 RGPD1 KATNIP IP6K1 FOXP3	6.82e-04	1392	37	11	MP:0009205
Domain	GCC2_Rab_bind	RGPD4 RGPD3 RGPD1	6.27e-07	7	50	3	IPR032023
Domain	Rab_bind	RGPD4 RGPD3 RGPD1	6.27e-07	7	50	3	PF16704
Domain	-	RGPD4 RGPD3 RGPD1	2.14e-06	10	50	3	1.10.220.60
Domain	GRIP	RGPD4 RGPD3 RGPD1	2.93e-06	11	50	3	PF01465
Domain	Grip	RGPD4 RGPD3 RGPD1	2.93e-06	11	50	3	SM00755
Domain	Ran_BP1	RGPD4 RGPD3 RGPD1	3.90e-06	12	50	3	PF00638
Domain	GRIP_dom	RGPD4 RGPD3 RGPD1	3.90e-06	12	50	3	IPR000237
Domain	GRIP	RGPD4 RGPD3 RGPD1	3.90e-06	12	50	3	PS50913
Domain	RANBD1	RGPD4 RGPD3 RGPD1	3.90e-06	12	50	3	PS50196
Domain	RanBD	RGPD4 RGPD3 RGPD1	5.07e-06	13	50	3	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD3 RGPD1	5.07e-06	13	50	3	IPR000156
Domain	-	DPRX NKX2-4 NKX2-1 LHX6 MYB	9.36e-04	283	50	5	1.10.10.60
Domain	Homeobox_CS	DPRX NKX2-4 NKX2-1 LHX6	1.53e-03	186	50	4	IPR017970
Domain	Homeodomain-like	DPRX NKX2-4 NKX2-1 LHX6 MYB	1.89e-03	332	50	5	IPR009057
Domain	Homeobox	DPRX NKX2-4 NKX2-1 LHX6	3.52e-03	234	50	4	PF00046
Domain	HOMEOBOX_1	DPRX NKX2-4 NKX2-1 LHX6	3.63e-03	236	50	4	PS00027
Domain	HOX	DPRX NKX2-4 NKX2-1 LHX6	3.69e-03	237	50	4	SM00389
Domain	Homeobox_dom	DPRX NKX2-4 NKX2-1 LHX6	3.80e-03	239	50	4	IPR001356
Domain	HOMEOBOX_2	DPRX NKX2-4 NKX2-1 LHX6	3.80e-03	239	50	4	PS50071
Domain	TPR	RGPD4 RGPD3 RGPD1	4.98e-03	129	50	3	SM00028
Domain	C2	SYT16 UNC13D SYT7	5.20e-03	131	50	3	PF00168
Domain	TPR_repeat	RGPD4 RGPD3 RGPD1	5.42e-03	133	50	3	IPR019734
Domain	C2	SYT16 UNC13D SYT7	5.88e-03	137	50	3	SM00239
Domain	C2	SYT16 UNC13D SYT7	6.50e-03	142	50	3	PS50004
Domain	-	SYT16 UNC13D SYT7	7.28e-03	148	50	3	2.60.40.150
Domain	TPR-contain_dom	RGPD4 RGPD3 RGPD1	7.55e-03	150	50	3	IPR013026
Domain	C2_dom	SYT16 UNC13D SYT7	9.63e-03	164	50	3	IPR000008
Domain	TPR	RGPD4 RGPD3 RGPD1	9.79e-03	165	50	3	PS50005
Domain	TPR_REGION	RGPD4 RGPD3 RGPD1	9.79e-03	165	50	3	PS50293
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD4 RGPD3 RGPD1	1.55e-05	18	39	3	MM1549
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD4 RGPD3 RGPD1	1.80e-04	40	39	3	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD4 RGPD3 RGPD1	1.94e-04	41	39	3	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD4 RGPD3 RGPD1	2.09e-04	42	39	3	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD4 RGPD3 RGPD1	2.24e-04	43	39	3	MM14609
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RGPD4 RGPD3 RGPD1	2.92e-04	47	39	3	MM14939
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RGPD4 RGPD3 RGPD1	3.30e-04	49	39	3	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD4 RGPD3 RGPD1	3.51e-04	50	39	3	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RGPD4 RGPD3 RGPD1	3.72e-04	51	39	3	MM15151
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RGPD4 RGPD3 RGPD1	4.65e-04	55	39	3	MM14917
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RGPD4 RGPD3 RGPD1	5.44e-04	58	39	3	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	RGPD4 RGPD3 RGPD1	5.44e-04	58	39	3	MM14736
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RGPD4 RGPD3 RGPD1	7.59e-04	65	39	3	MM15147
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RGPD4 RGPD3 RGPD1	1.07e-03	73	39	3	MM14948
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	8603673
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	15710750
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD3 RGPD1	1.16e-07	7	53	3	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD3 RGPD1	1.86e-07	8	53	3	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD3 RGPD1	1.86e-07	8	53	3	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD3 RGPD1	1.86e-07	8	53	3	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD3 RGPD1	1.86e-07	8	53	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD3 RGPD1	1.86e-07	8	53	3	21310149
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	18394993
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	28100513
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD3 RGPD1	2.79e-07	9	53	3	17887960
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD3 RGPD1	3.98e-07	10	53	3	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD3 RGPD1	3.98e-07	10	53	3	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD3 RGPD1	3.98e-07	10	53	3	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD3 RGPD1	3.98e-07	10	53	3	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD3 RGPD1	5.47e-07	11	53	3	35771867
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD3 RGPD1	5.47e-07	11	53	3	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RGPD3 RGPD1	5.47e-07	11	53	3	34110283
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD3 RGPD1	9.45e-07	13	53	3	31427429
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RGPD3 RGPD1	1.50e-06	15	53	3	14697343
Pubmed	STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer.	TET2 FOXP3	2.28e-06	2	53	2	30013992
Pubmed	Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis.	TET2 FOXP3	2.28e-06	2	53	2	31778687
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD4 RGPD3 RGPD1	5.04e-06	22	53	3	27717094
Pubmed	Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb.	MYB FOXP3	6.83e-06	3	53	2	28099866
Pubmed	Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells.	TET2 FOXP3	6.83e-06	3	53	2	24984151
Pubmed	Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation.	TET2 FOXP3	6.83e-06	3	53	2	29048538
Pubmed	Control of Foxp3 stability through modulation of TET activity.	TET2 FOXP3	6.83e-06	3	53	2	26903244
Pubmed	Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.	RPS6KA1 APAF1	6.83e-06	3	53	2	22246185
Pubmed	NKX2.1 specifies cortical interneuron fate by activating Lhx6.	NKX2-1 LHX6	6.83e-06	3	53	2	18339674
Pubmed	Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression.	TET2 FOXP3	1.36e-05	4	53	2	30726915
Pubmed	Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.	APOB FOXP3	1.36e-05	4	53	2	29588316
Pubmed	Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb.	NKX2-1 MYB	1.36e-05	4	53	2	25763778
Pubmed	The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.	ZNF75D ZNF75CP	1.36e-05	4	53	2	8661144
Pubmed	DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.	TET2 FOXP3	2.27e-05	5	53	2	36880575
Pubmed	Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death.	NKX2-1 APAF1	2.27e-05	5	53	2	19913007
Pubmed	Loss of TET2 and TET3 in regulatory T cells unleashes effector function.	TET2 FOXP3	2.27e-05	5	53	2	31043609
Pubmed	Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain.	NKX2-4 NKX2-1	2.27e-05	5	53	2	1346742
Pubmed	Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis.	TET2 FOXP3	2.27e-05	5	53	2	26275994
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD4 RGPD3 RGPD1	2.71e-05	38	53	3	12791264
Pubmed	Developmental specification of forebrain cholinergic neurons.	NKX2-1 LHX6	3.40e-05	6	53	2	27847324
Pubmed	Insulin signaling establishes a developmental trajectory of adipose regulatory T cells.	MED23 FOXP3	3.40e-05	6	53	2	34429546
Pubmed	A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex.	ST8SIA2 LHX6	6.34e-05	8	53	2	24993945
Pubmed	Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors.	NKX2-1 LHX6	6.34e-05	8	53	2	18786357
Pubmed	Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons.	NKX2-1 LHX6	8.15e-05	9	53	2	33479483
Pubmed	Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.	NKX2-4 NKX2-1	8.15e-05	9	53	2	9344671
Pubmed	The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.	NKX2-1 LHX6	8.15e-05	9	53	2	26305926
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	RGPD4 IPO7 RGPD3 RGPD1	8.92e-05	153	53	4	26365490
Pubmed	Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.	NKX2-1 LHX6	1.02e-04	10	53	2	30571765
Pubmed	Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder.	NKX2-1 LHX6	1.02e-04	10	53	2	36819097
Pubmed	The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations.	NKX2-1 LHX6	1.02e-04	10	53	2	12411960
Pubmed	Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon.	NKX2-1 LHX6	1.02e-04	10	53	2	12902388
Pubmed	Distinct cortical migrations from the medial and lateral ganglionic eminences.	NKX2-1 LHX6	1.02e-04	10	53	2	11152634
Pubmed	Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.	NKX2-1 LHX6	1.24e-04	11	53	2	35544642
Pubmed	Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.	NKX2-4 NKX2-1	1.49e-04	12	53	2	11830575
Pubmed	Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development.	NKX2-1 LHX6	1.49e-04	12	53	2	17990271
Pubmed	Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy.	NKX2-1 LHX6	1.49e-04	12	53	2	21430164
Pubmed	Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome.	NKX2-1 LHX6	1.49e-04	12	53	2	20639873
Pubmed	Distinct hyperactive RAS/MAPK alleles converge on common GABAergic interneuron core programs.	NKX2-1 LHX6	1.76e-04	13	53	2	37254876
Pubmed	The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1.	NKX2-1 LHX6	1.76e-04	13	53	2	22098391
Pubmed	Pax6 modulates the dorsoventral patterning of the mammalian telencephalon.	NKX2-1 LHX6	2.05e-04	14	53	2	11050125
Pubmed	NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory.	NKX2-1 LHX6	2.05e-04	14	53	2	28813670
Pubmed	Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.	NKX2-1 LHX6	2.05e-04	14	53	2	12379852
Pubmed	The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum.	NKX2-1 LHX6	2.05e-04	14	53	2	21048141
Pubmed	Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice.	NKX2-1 LHX6	2.05e-04	14	53	2	16766714
Pubmed	The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.	NKX2-1 LHX6	2.36e-04	15	53	2	21205786
Pubmed	Origin and molecular specification of striatal interneurons.	NKX2-1 LHX6	2.36e-04	15	53	2	10934256
Pubmed	A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.	NKX2-1 LHX6	2.36e-04	15	53	2	21943598
Pubmed	Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.	NKX2-1 LHX6	2.36e-04	15	53	2	16615895
Pubmed	Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning.	NKX2-1 LHX6	2.70e-04	16	53	2	12930780
Pubmed	Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex.	NKX2-1 LHX6	2.70e-04	16	53	2	21338885
Pubmed	Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes.	NKX2-1 LHX6	2.70e-04	16	53	2	17804629
Pubmed	Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells.	NKX2-1 APAF1	2.70e-04	16	53	2	24369835
Pubmed	Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution.	NKX2-1 LHX6	3.05e-04	17	53	2	21435555
Pubmed	Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification.	NKX2-1 LHX6	3.05e-04	17	53	2	18329011
Pubmed	A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area.	NKX2-1 LHX6	3.05e-04	17	53	2	22090484
Pubmed	Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala.	NKX2-1 LHX6	3.05e-04	17	53	2	20507551
Pubmed	Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin.	NKX2-1 LHX6	3.05e-04	17	53	2	25116473
Pubmed	FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon.	NKX2-1 LHX6	3.05e-04	17	53	2	28483978
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	RGPD4 RGPD3 RGPD1	3.13e-04	86	53	3	37253089
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF680 IPO7 NKX2-1 WDR70 CHD1 BOD1L1	3.18e-04	608	53	6	36089195
Interaction	RGPD4 interactions	RGPD4 RGPD3 RGPD1	1.89e-05	22	48	3	int:RGPD4
Interaction	RGPD2 interactions	RGPD4 RGPD3 RGPD1	3.56e-05	27	48	3	int:RGPD2
Interaction	SATB2 interactions	DPRX NKX2-1 LHX6 MYB FOXP3	3.74e-05	159	48	5	int:SATB2
GeneFamily	Synaptotagmins	SYT16 SYT7	5.14e-04	17	36	2	765
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RGPD3 RGPD1	1.54e-03	115	36	3	769
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX2-4 NKX2-1	7.86e-03	67	36	2	519
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TET2 RGPD1 EXT1 MYB FOXP3	3.18e-06	191	53	5	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
Drug	IRFI005	KEL APOB	4.73e-06	2	50	2	CID000132223
Disease	LDL cholesterol change measurement	APOB PKD1L3	5.64e-05	7	49	2	EFO_0007804
Disease	adult T-cell leukemia/lymphoma (is_marker_for)	MYB FOXP3	9.65e-05	9	49	2	DOID:0050523 (is_marker_for)
Disease	Neonatal diabetes mellitus	ZFP57 FOXP3	7.91e-04	25	49	2	C0158981
Disease	blood rubidium measurement	INSL6 ABCA13	8.56e-04	26	49	2	EFO_0021529
Disease	Sezary Syndrome	TET2 RPS6KA1	9.23e-04	27	49	2	C0036920
Disease	L-arginine measurement	MED23 MYB	9.23e-04	27	49	2	EFO_0006524
Disease	cognitive function measurement	FBXW12 TTLL2 EXD2 ZFP57 IP6K1 EXT1 PKD1L3 SYT7	2.32e-03	1434	49	8	EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
FQSRFQHKKTVWHIQ	APAF1	996	O14727
HNWKLKHTVPENIKR	CATSPERB	981	Q9H7T0
HTFPKILQHLWKLQS	ABCA13	416	Q86UQ4
WTHHQTKRLKFNILL	CHD1	576	O14646
ANIRHWINPKKESIH	CFAP276	126	Q5T5A4
TPTQVKIWFQNHRYK	NKX2-1	201	P43699
HLQKVKPQWFNRTTH	KCNK18	86	Q7Z418
IHLTPTQVKIWFQNH	NKX2-4	226	Q9H2Z4
NHPATWKNAIRHNLS	FOXP3	376	Q9BZS1
SVLWPHSHNQAQKKE	EURL	186	Q9NYK6
PSKVQRRGWHQKSVQ	KATNIP	126	O60303
PQQWSVDHNHQKLLR	EXD2	596	Q9NVH0
GTHTWKQFFLHQRRK	FBXW12	61	Q6X9E4
QGVSHALTWKNLKPH	IPO7	331	O95373
QWIVKFIHGQHSPKR	MED23	61	Q9ULK4
WFQNCRARHKKHTPQ	LHX6	266	Q9UPM6
HKNPKVQLWSTYQVR	METTL23	121	Q86XA0
RERWHNHLNPEVKKT	MYB	131	P10242
PVWAQNHRTVAAAHK	PTGDR2	136	Q9Y5Y4
HPTVLQVWFKNHRAK	DPRX	56	A6NFQ7
KWLKQLFHHLPQETS	RGPD3	456	A6NKT7
THTWSPHLNKNQLRN	BOD1L1	101	Q8NFC6
KHAWIHQSRNLKPQP	DYRK4	396	Q9NR20
STHILQWLKRVHANP	APOB	391	P04114
KHISRNSLIWNKHPG	EXT1	436	Q16394
EKISHNPWSLRCHKQ	IP6K1	176	Q92551
SHPRATQQWILKNKT	LINC01546	41	A6NGU7
KQVQWSHRPFQKSKA	FAM186A	1706	A6NE01
WHKNLTGPQIITLNH	IL17RC	321	Q8NAC3
ERHTQIQWKKHSYPF	NXPE1	391	Q8N323
RKWLKQLFHHLPQET	RGPD1	446	P0DJD0
VKRKNLNPHWNETFL	SYT7	191	O43581
KWLKQLFHHLPQETS	RGPD4	456	Q7Z3J3
LAQKWHLIKQHTAPV	SOCS5	226	O75159
NSWQVHVVLLPGKKH	SYT16	386	Q17RD7
KTLSNLFWGHHPQRK	INSL6	156	Q9Y581
PKIVHSNWNILNNFH	FASTKD2	51	Q9NYY8
HFHLNITLPKDKVWQ	PKD1L3	571	Q7Z443
KHNIQPASSKWRHNQ	ST8SIA2	76	Q92186
LEHQQWHKDRKNPSL	SNAPC1	221	Q16533
VKKPNWAHSVNPVHL	C12orf42	171	Q96LP6
SRLVRHQQTHWKQKS	ZFP57	341	Q9NU63
HQQTHWKQKSYLCPI	ZFP57	346	Q9NU63
QGLPNHHWRITFINK	MTM1	176	Q13496
KWHKRQSTHQRPRQF	TRABD2B	426	A6NFA1
IQIWDRNLTVHPKFH	WDR70	356	Q9NW82
LPKGTQNWVQKHHPQ	ZNF75CP	101	Q92670
WQQLNHHPGTTKLTR	TTLL2	141	Q9BWV7
LPKETQNWVQKHHPQ	ZNF75D	101	P51815
PPQKDTQKHAALRWH	TET2	941	Q6N021
FNWPATLANHKRIHA	ZNF680	471	Q8NEM1
QRTWDKIFHNTLKIH	UNC13D	506	Q70J99
LQKEHPVNWHKNYAI	TMEM260	631	Q9NX78
QSFLQPHPQHRWKVS	KEL	521	P23276
HQRLTAKQVLQHPWV	RPS6KA1	661	Q15418