Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHGC5 DSG2 ITGB1 CNTN6 FAT1 CADM1 PCDH11X DSG4	4.48e-06	187	103	8	GO:0007156
GeneOntologyCellularComponent	collagen type IV trimer	COL4A3 COL4A4 COL4A5	2.37e-06	6	104	3	GO:0005587
GeneOntologyCellularComponent	basement membrane collagen trimer	COL4A3 COL4A4 COL4A5	6.58e-06	8	104	3	GO:0098651
GeneOntologyCellularComponent	network-forming collagen trimer	COL4A3 COL4A4 COL4A5	6.58e-06	8	104	3	GO:0098642
GeneOntologyCellularComponent	collagen network	COL4A3 COL4A4 COL4A5	6.58e-06	8	104	3	GO:0098645
GeneOntologyCellularComponent	complex of collagen trimers	COL4A3 COL4A4 COL4A5	1.49e-04	21	104	3	GO:0098644
GeneOntologyCellularComponent	basement membrane	COL4A3 COL4A4 COL4A5 ITGB1 TIMP2	3.62e-04	122	104	5	GO:0005604
GeneOntologyCellularComponent	hippocampal mossy fiber	MAPK8IP1 MAP1B	5.07e-04	7	104	2	GO:0097457
HumanPheno	Glomerular basement membrane lamellation	COL4A3 COL4A4 COL4A5	4.49e-07	3	40	3	HP:0030034
Domain	C4	COL4A3 COL4A4 COL4A5	3.22e-06	6	103	3	SM00111
Domain	Collagen_VI_NC	COL4A3 COL4A4 COL4A5	3.22e-06	6	103	3	IPR001442
Domain	NC1_IV	COL4A3 COL4A4 COL4A5	3.22e-06	6	103	3	PS51403
Domain	-	COL4A3 COL4A4 COL4A5	3.22e-06	6	103	3	2.170.240.10
Domain	C4	COL4A3 COL4A4 COL4A5	3.22e-06	6	103	3	PF01413
Domain	Desmoglein	DSG2 DSG4	1.79e-04	4	103	2	IPR009123
Domain	Cadherin_CS	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	3.43e-04	109	103	5	IPR020894
Domain	CADHERIN_1	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.05e-04	113	103	5	PS00232
Domain	Cadherin	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.05e-04	113	103	5	PF00028
Domain	CADHERIN_2	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.22e-04	114	103	5	PS50268
Domain	-	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.22e-04	114	103	5	2.60.40.60
Domain	CA	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.39e-04	115	103	5	SM00112
Domain	Cadherin-like	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.57e-04	116	103	5	IPR015919
Domain	Cadherin	PCDHGC5 DSG2 FAT1 PCDH11X DSG4	4.94e-04	118	103	5	IPR002126
Domain	Ig-like_fold	HFE CAMTA2 ISLR IFNLR1 CNTN6 MET CADM1 LRFN2 CD7 AGER CNTN3 PLXNB1	5.10e-04	706	103	12	IPR013783
Domain	Desmosomal_cadherin	DSG2 DSG4	6.21e-04	7	103	2	IPR009122
Domain	Ig_I-set	ISLR CNTN6 CADM1 LRFN2 AGER CNTN3	6.47e-04	190	103	6	IPR013098
Domain	I-set	ISLR CNTN6 CADM1 LRFN2 AGER CNTN3	6.47e-04	190	103	6	PF07679
Domain	TIG	CAMTA2 MET PLXNB1	6.54e-04	31	103	3	PF01833
Domain	IPT	CAMTA2 MET PLXNB1	7.19e-04	32	103	3	IPR002909
Domain	-	HFE ISLR IFNLR1 CNTN6 MET CADM1 LRFN2 CD7 AGER CNTN3 PLXNB1	1.07e-03	663	103	11	2.60.40.10
Domain	BAH	ORC1 PBRM1	1.60e-03	11	103	2	PS51038
Domain	DHR-1_domain	DOCK2 DOCK10	1.60e-03	11	103	2	IPR027007
Domain	DHR_2	DOCK2 DOCK10	1.60e-03	11	103	2	PS51651
Domain	DHR_1	DOCK2 DOCK10	1.60e-03	11	103	2	PS51650
Domain	DHR-2	DOCK2 DOCK10	1.60e-03	11	103	2	PF06920
Domain	DOCK	DOCK2 DOCK10	1.60e-03	11	103	2	IPR026791
Domain	BAH_dom	ORC1 PBRM1	1.60e-03	11	103	2	IPR001025
Domain	BAH	ORC1 PBRM1	1.60e-03	11	103	2	SM00439
Domain	BAH	ORC1 PBRM1	1.60e-03	11	103	2	PF01426
Domain	DOCK_C	DOCK2 DOCK10	1.60e-03	11	103	2	IPR010703
Domain	DOCK-C2	DOCK2 DOCK10	1.60e-03	11	103	2	PF14429
Domain	DHR-2	DOCK2 DOCK10	1.60e-03	11	103	2	IPR027357
Domain	PSI	ITGB1 MET PLXNB1	1.83e-03	44	103	3	IPR016201
Domain	C8	ZAN SSPOP	1.92e-03	12	103	2	PF08742
Domain	TIL	ZAN SSPOP	1.92e-03	12	103	2	PF01826
Domain	IGc2	ISLR CNTN6 CADM1 LRFN2 AGER CNTN3	1.93e-03	235	103	6	SM00408
Domain	Ig_sub2	ISLR CNTN6 CADM1 LRFN2 AGER CNTN3	1.93e-03	235	103	6	IPR003598
Domain	PSI	ITGB1 MET PLXNB1	2.08e-03	46	103	3	SM00423
Domain	Unchr_dom_Cys-rich	ZAN SSPOP	2.26e-03	13	103	2	IPR014853
Domain	C8	ZAN SSPOP	2.26e-03	13	103	2	SM00832
Domain	TIL_dom	ZAN SSPOP	2.62e-03	14	103	2	IPR002919
Domain	VWF_type-D	ZAN SSPOP	3.44e-03	16	103	2	IPR001846
Domain	VWFD	ZAN SSPOP	3.44e-03	16	103	2	PS51233
Domain	VWD	ZAN SSPOP	3.44e-03	16	103	2	SM00216
Domain	VWD	ZAN SSPOP	3.44e-03	16	103	2	PF00094
Domain	MAM	ZAN MALRD1	3.88e-03	17	103	2	SM00137
Domain	MAM	ZAN MALRD1	4.35e-03	18	103	2	PF00629
Domain	MAM_dom	ZAN MALRD1	4.35e-03	18	103	2	IPR000998
Domain	MAM_2	ZAN MALRD1	4.35e-03	18	103	2	PS50060
Domain	VWC_out	ZAN SSPOP	4.84e-03	19	103	2	SM00215
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A3 COL4A4 COL4A5 ITGB1	1.07e-06	15	77	4	MM14922
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A3 COL4A4 COL4A5	1.83e-05	10	77	3	M22040
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A3 COL4A4 COL4A5	1.83e-05	10	77	3	MM1560
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A3 COL4A4 COL4A5 ITGB1	2.02e-05	30	77	4	M27216
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A3 COL4A4 COL4A5	2.51e-05	11	77	3	M15422
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL4A3 COL4A4 COL4A5 ITGB1	2.63e-05	32	77	4	MM14924
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A3 COL4A4 COL4A5	3.33e-05	12	77	3	MM1526
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A3 COL4A4 COL4A5	4.31e-05	13	77	3	MM1347
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A3 COL4A4 COL4A5	4.31e-05	13	77	3	M12950
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	DOCK2 INCENP DSG2 NUP98 DOCK10 PRAG1 ITGB1 SKA1 GARRE1 DDX39B CEP97 DYNC1H1 PLXNB1	4.48e-05	649	77	13	MM15690
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	COL4A3 COL4A4 COL4A5 ITGB1 FAT1	4.48e-05	72	77	5	M39403
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	COL4A3 COL4A4 COL4A5 ITGB1 FAT1	4.79e-05	73	77	5	MM15906
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL4A3 COL4A4 COL4A5 SPTB	5.27e-05	38	77	4	MM14969
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A3 COL4A4 COL4A5	5.46e-05	14	77	3	MM1458
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A3 COL4A4 COL4A5	5.46e-05	14	77	3	M6487
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	COL4A3 COL4A4 COL4A5	6.80e-05	15	77	3	M27161
Pathway	REACTOME_RAC2_GTPASE_CYCLE	DOCK2 DSG2 DOCK10 ITGB1 GARRE1	1.11e-04	87	77	5	MM15600
Pathway	PID_SYNDECAN_1_PATHWAY	COL4A3 COL4A4 COL4A5 MET	1.13e-04	46	77	4	M198
Pathway	REACTOME_RAC2_GTPASE_CYCLE	DOCK2 DSG2 DOCK10 ITGB1 GARRE1	1.17e-04	88	77	5	M41810
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A3 COL4A4 COL4A5	1.21e-04	18	77	3	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A3 COL4A4 COL4A5	1.21e-04	18	77	3	MM14882
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	DOCK2 INCENP DSG2 NUP98 DOCK10 PRAG1 ITGB1 SKA1 GARRE1 DDX39B CEP97 DYNC1H1 PLXNB1	1.28e-04	720	77	13	M41838
Pathway	BIOCARTA_AMI_PATHWAY	COL4A3 COL4A4 COL4A5	1.67e-04	20	77	3	M15394
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A3 COL4A4 COL4A5	1.67e-04	20	77	3	MM15061
Pathway	BIOCARTA_INTRINSIC_PATHWAY	COL4A3 COL4A4 COL4A5	2.57e-04	23	77	3	M15997
Pathway	BIOCARTA_INTRINSIC_PATHWAY	COL4A3 COL4A4 COL4A5	2.57e-04	23	77	3	MM1427
Pathway	REACTOME_MET_INTERACTS_WITH_TNS_PROTEINS	ITGB1 MET	2.91e-04	5	77	2	M27775
Pathway	REACTOME_MET_INTERACTS_WITH_TNS_PROTEINS	ITGB1 MET	2.91e-04	5	77	2	MM15514
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL4A3 COL4A4 COL4A5 ITGB1	2.98e-04	59	77	4	M27218
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL4A3 COL4A4 COL4A5 SPTB	3.84e-04	63	77	4	M11187
Pathway	PID_INTEGRIN1_PATHWAY	COL4A3 COL4A4 COL4A5 ITGB1	4.59e-04	66	77	4	M18
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	COL4A3 COL4A4 COL4A5 SPTB ITGB1 MET PLXNB1	5.49e-04	261	77	7	MM15676
Pathway	REACTOME_RHOG_GTPASE_CYCLE	DOCK2 DSG2 ITGB1 GARRE1	6.06e-04	71	77	4	MM15604
Pathway	REACTOME_RHO_GTPASE_CYCLE	DOCK2 DSG2 DOCK10 PRAG1 ITGB1 GARRE1 DDX39B CEP97 PLXNB1	6.27e-04	439	77	9	MM15595
Pathway	REACTOME_RHOG_GTPASE_CYCLE	DOCK2 DSG2 ITGB1 GARRE1	7.09e-04	74	77	4	M41814
Pathway	REACTOME_RHO_GTPASE_CYCLE	DOCK2 DSG2 DOCK10 PRAG1 ITGB1 GARRE1 DDX39B CEP97 PLXNB1	7.48e-04	450	77	9	M27078
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL4A3 COL4A4 COL4A5 ITGB1	7.84e-04	76	77	4	MM14867
Pathway	REACTOME_ECM_PROTEOGLYCANS	COL4A3 COL4A4 COL4A5 ITGB1	7.84e-04	76	77	4	M27219
Pathway	REACTOME_SEMA4D_MEDIATED_INHIBITION_OF_CELL_ATTACHMENT_AND_MIGRATION	MET PLXNB1	8.07e-04	8	77	2	M27325
Pathway	REACTOME_SEMA4D_MEDIATED_INHIBITION_OF_CELL_ATTACHMENT_AND_MIGRATION	MET PLXNB1	8.07e-04	8	77	2	MM15045
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	INCENP NUP98 ITGB1 SKA1 DYNC1H1	1.00e-03	140	77	5	M27550
Pathway	REACTOME_CHL1_INTERACTIONS	ITGB1 CNTN6	1.03e-03	9	77	2	M27379
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	NUP98 NUP210 DDX39A DDX39B	1.14e-03	84	77	4	M725
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL4A3 COL4A4 COL4A5 ITGB1	1.19e-03	85	77	4	M16441
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	NUP98 NUP210 DDX39A DDX39B	1.25e-03	86	77	4	MM15413
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A3 COL4A4 COL4A5	1.44e-03	41	77	3	MM15538
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A3 COL4A4 COL4A5	1.54e-03	42	77	3	M7169
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1B RYR1	1.57e-03	11	77	2	M47958
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	COL4A3 COL4A4 COL4A5 DSG2 SPTB ITGB1 MET DSG4 PLXNB1	1.61e-03	502	77	9	MM14537
Pathway	PID_INTEGRIN3_PATHWAY	COL4A3 COL4A4 COL4A5	1.65e-03	43	77	3	M53
Pathway	REACTOME_RAC3_GTPASE_CYCLE	DSG2 DOCK10 ITGB1 GARRE1	1.66e-03	93	77	4	MM15609
Pathway	REACTOME_RAC3_GTPASE_CYCLE	DSG2 DOCK10 ITGB1 GARRE1	1.73e-03	94	77	4	M41818
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A3 COL4A4 COL4A5	1.77e-03	44	77	3	M27812
Pathway	WP_SMALL_CELL_LUNG_CANCER	COL4A3 COL4A4 COL4A5 ITGB1	1.87e-03	96	77	4	M39834
Pathway	WP_NEPHROTIC_SYNDROME	COL4A3 COL4A4 COL4A5	1.89e-03	45	77	3	M39864
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	INCENP NUP98 NUP210	2.01e-03	46	77	3	M27397
Pathway	REACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES	INCENP NUP98 SKA1 DYNC1H1	2.17e-03	100	77	4	MM14561
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	COL4A3 COL4A4 COL4A5	2.55e-03	50	77	3	MM14796
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	INCENP NUP98 NUP210	2.70e-03	51	77	3	MM15151
Pubmed	Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.	COL4A3 COL4A4 COL4A5 ITGB1	2.73e-09	7	105	4	7521231
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GNL3L DSG2 HLCS PEX1 GAS7 INO80D ZKSCAN5 TRIM66 PASK FAT1 PBRM1 ZZZ3 TRAFD1 ZFHX4 CAPRIN2 CSMD1 GARRE1 UNC80	6.54e-09	1116	105	18	31753913
Pubmed	Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	27576055
Pubmed	A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	24522496
Pubmed	Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	7962065
Pubmed	Autosomal dominant form of type IV collagen nephropathy exists among patients with hereditary nephritis difficult to diagnose clinicopathologically.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	28704582
Pubmed	Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	30647093
Pubmed	Genetic Variants of the COL4A3 , COL4A4 , and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	36130833
Pubmed	Genetic diagnosis of Alport syndrome in 16 Chinese families.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	38433557
Pubmed	Characterization of assembly of recombinant type IV collagen alpha3, alpha4, and alpha5 chains in transfected cell strains.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	14633121
Pubmed	Novel COL4A5, COL4A4, and COL4A3 mutations in Alport syndrome.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	15954103
Pubmed	Alport syndrome: impact of digenic inheritance in patients management.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	27859054
Pubmed	Sixteen novel mutations identified in COL4A3, COL4A4, and COL4A5 genes in Slovenian families with Alport syndrome and benign familial hematuria.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	17396119
Pubmed	Novel mutations in COL4A3, COL4A4, and COL4A5 in Chinese patients with Alport Syndrome.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	28542346
Pubmed	Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	18930919
Pubmed	Four novel mutations identified in the COL4A3, COL4A4 and COL4A5 genes in 10 families with Alport syndrome.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	38978054
Pubmed	Alport Syndrome	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	20301386
Pubmed	A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	14507670
Pubmed	Evidence of digenic inheritance in Alport syndrome.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	25575550
Pubmed	Unbiased next generation sequencing analysis confirms the existence of autosomal dominant Alport syndrome in a relevant fraction of cases.	COL4A3 COL4A4 COL4A5	2.67e-08	3	105	3	24033287
Pubmed	Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.	COL4A3 COL4A4 COL4A5 ITGB1	1.81e-07	17	105	4	18082680
Pubmed	Extracellular matrix of the human optic nerve head.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	2426947
Pubmed	Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	10534397
Pubmed	Developmental distribution of collagen IV isoforms and relevance to ocular diseases.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	19275937
Pubmed	Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	6988303
Pubmed	Stimulation of extracellular matrix components in the normal brain by invading glioma cells.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	9506531
Pubmed	HIV-1 gp160 protein-macrophage interactions modulate mesangial cell proliferation and matrix synthesis.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	7495302
Pubmed	Angiogenesis and collagen type IV expression in different endothelial cell culture systems.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	23551189
Pubmed	Monoclonal antibody to human basement membrane collagen type IV.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	6811420
Pubmed	Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	6389236
Pubmed	Collagen IV in the developing lens capsule.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	12225806
Pubmed	A tumor derived motility factor that stimulates cell migration on extracellular matrix.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	9673377
Pubmed	Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development.	COL4A3 COL4A4 COL4A5	5.31e-07	6	105	3	11732842
Pubmed	Regulation of protease nexin-1 target protease specificity by collagen type IV.	COL4A3 COL4A4 COL4A5	9.28e-07	7	105	3	8006028
Pubmed	Corneal cell proteins and ocular surface pathology.	COL4A3 COL4A4 COL4A5	9.28e-07	7	105	3	10416788
Pubmed	Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).	COL4A3 COL4A4 COL4A5	9.28e-07	7	105	3	10716744
Pubmed	Nidogen-1. Expression and ultrastructural localization during the onset of mesoderm formation in the early mouse embryo.	COL4A3 COL4A4 COL4A5	9.28e-07	7	105	3	10639489
Pubmed	Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.	COL4A3 COL4A4 COL4A5	9.28e-07	7	105	3	11711546
Pubmed	Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.	COL4A3 COL4A4 COL4A5	9.28e-07	7	105	3	1724753
Pubmed	Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.	COL4A3 COL4A4 COL4A5 ITGB1	1.11e-06	26	105	4	24742657
Pubmed	Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.	COL4A3 COL4A4 COL4A5	1.48e-06	8	105	3	3997552
Pubmed	Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.	COL4A3 COL4A4 COL4A5	1.48e-06	8	105	3	29422532
Pubmed	Mice develop normally without tenascin.	COL4A3 COL4A4 COL4A5	1.48e-06	8	105	3	1383086
Pubmed	Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.	COL4A3 COL4A4 COL4A5	1.48e-06	8	105	3	10382266
Pubmed	Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.	COL4A3 COL4A4 COL4A5	1.48e-06	8	105	3	11683410
Pubmed	Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis.	COL4A3 COL4A4 COL4A5	2.22e-06	9	105	3	8562707
Pubmed	Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.	COL4A3 COL4A4 COL4A5	2.22e-06	9	105	3	12101409
Pubmed	Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy.	COL4A3 COL4A4 COL4A5	2.22e-06	9	105	3	35499085
Pubmed	MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation?	COL4A3 COL4A4 COL4A5	2.22e-06	9	105	3	9878537
Pubmed	Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.	DSG2 FAT1 DSG4	3.16e-06	10	105	3	12724416
Pubmed	Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.	COL4A3 COL4A4 COL4A5	3.16e-06	10	105	3	9415455
Pubmed	Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.	COL4A3 COL4A4 COL4A5	3.16e-06	10	105	3	9136074
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	COL4A3 CACNA1B COL4A4 DOCK10 RYR1 ORC1 CAPRIN2	3.43e-06	208	105	7	33230847
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	COL4A3 COL4A4 COL4A5	4.33e-06	11	105	3	7500359
Pubmed	Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development.	COL4A3 COL4A4 COL4A5	4.33e-06	11	105	3	14998921
Pubmed	Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3.	COL4A3 COL4A4 COL4A5	4.33e-06	11	105	3	9731539
Pubmed	Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice.	COL4A3 COL4A4 COL4A5	5.77e-06	12	105	3	8918877
Pubmed	Basement membrane fragility underlies embryonic lethality in fukutin-null mice.	COL4A3 COL4A4 COL4A5	5.77e-06	12	105	3	15837576
Pubmed	Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.	COL4A3 COL4A4 COL4A5	5.77e-06	12	105	3	16024816
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	COL4A3 COL4A4 COL4A5	5.77e-06	12	105	3	12180907
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	COL4A3 COL4A4 COL4A5	7.48e-06	13	105	3	9833687
Pubmed	Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.	DDX39A DDX39B	9.03e-06	2	105	2	16949217
Pubmed	Two genes, COL4A3 and COL4A4 coding for the human alpha3(IV) and alpha4(IV) collagen chains are arranged head-to-head on chromosome 2q36.	COL4A3 COL4A4	9.03e-06	2	105	2	9537506
Pubmed	Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.	DDX39A DDX39B	9.03e-06	2	105	2	20610707
Pubmed	The clinical spectrum of type IV collagen mutations.	COL4A4 COL4A5	9.03e-06	2	105	2	9195222
Pubmed	Identification of mutations in the alpha 3(IV) and alpha 4(IV) collagen genes in autosomal recessive Alport syndrome.	COL4A3 COL4A4	9.03e-06	2	105	2	7987396
Pubmed	The COL4A3 and COL4A4 Digenic Mutations in cis Result in Benign Familial Hematuria in a Large Chinese Family.	COL4A3 COL4A4	9.03e-06	2	105	2	29742505
Pubmed	Is there a dominant-negative effect in individuals with heterozygous disease-causing variants in COL4A3/COL4A4?	COL4A3 COL4A4	9.03e-06	2	105	2	38214412
Pubmed	Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.	DDX39A DDX39B	9.03e-06	2	105	2	38225262
Pubmed	COL4A3/COL4A4 mutations and features in individuals with autosomal recessive Alport syndrome.	COL4A3 COL4A4	9.03e-06	2	105	2	24052634
Pubmed	Clinico-pathological correlations in 127 patients in 11 large pedigrees, segregating one of three heterozygous mutations in the COL4A3/ COL4A4 genes associated with familial haematuria and significant late progression to proteinuria and chronic kidney disease from focal segmental glomerulosclerosis.	COL4A3 COL4A4	9.03e-06	2	105	2	19357112
Pubmed	Mutation detection of COL4An gene based on mRNA of peripheral blood lymphocytes and prenatal diagnosis of Alport syndrome in China.	COL4A3 COL4A5	9.03e-06	2	105	2	21143337
Pubmed	Frequent COL4 mutations in familial microhematuria accompanied by later-onset Alport nephropathy due to focal segmental glomerulosclerosis.	COL4A4 COL4A5	9.03e-06	2	105	2	28632965
Pubmed	Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.	COL4A3 COL4A4	9.03e-06	2	105	2	25229338
Pubmed	Persistent familial hematuria in children and the locus for thin basement membrane nephropathy.	COL4A3 COL4A4	9.03e-06	2	105	2	16235097
Pubmed	Presumed COL4A3/COL4A4 Missense/Synonymous Variants Induce Aberrant Splicing.	COL4A3 COL4A4	9.03e-06	2	105	2	35386907
Pubmed	COL4A3/COL4A4 mutations: from familial hematuria to autosomal-dominant or recessive Alport syndrome.	COL4A3 COL4A4	9.03e-06	2	105	2	12028435
Pubmed	Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing.	DDX39A DDX39B	9.03e-06	2	105	2	38801080
Pubmed	COL4A3/COL4A4 mutations link familial hematuria and focal segmental glomerulosclerosis. glomerular epithelium destruction via basement membrane thinning?	COL4A3 COL4A4	9.03e-06	2	105	2	18661361
Pubmed	Does the maternal age affect the mesenchymal stem cell markers and gene expression in the human placenta? What is the evidence?	ITGB1 ENG	9.03e-06	2	105	2	26067657
Pubmed	Dsg2-mediated c-Met activation in anaplastic thyroid cancer motility and invasion.	DSG2 MET	9.03e-06	2	105	2	33022637
Pubmed	Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.	MET PLXNB1	9.03e-06	2	105	2	19940359
Pubmed	Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.	DDX39A DDX39B	9.03e-06	2	105	2	38377942
Pubmed	Mutation analysis of COL4A3 and COL4A4 genes in a Chinese autosomal-dominant Alport syndrome family.	COL4A3 COL4A4	9.03e-06	2	105	2	28674241
Pubmed	Heterozygous COL4A3/COL4A4 mutations: the hidden part of the iceberg?	COL4A3 COL4A4	9.03e-06	2	105	2	35090027
Pubmed	Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients.	HFE BRCA2	9.03e-06	2	105	2	16003728
Pubmed	Gene-trap expression screening to identify endothelial-specific genes.	PPP1R13B ENG	9.03e-06	2	105	2	15090446
Pubmed	Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism.	ITGB1 TIMP2	9.03e-06	2	105	2	16967503
Pubmed	Nine novel COL4A3 and COL4A4 mutations and polymorphisms identified in inherited membrane diseases.	COL4A3 COL4A4	9.03e-06	2	105	2	17216251
Pubmed	Heterozygous Urinary Abnormality-Causing Variants of COL4A3 and COL4A4 Affect Severity of Autosomal Recessive Alport Syndrome.	COL4A3 COL4A4	9.03e-06	2	105	2	35369551
Pubmed	Genotype-phenotype correlations for COL4A3-COL4A5 variants resulting in Gly substitutions in Alport syndrome.	COL4A3 COL4A5	9.03e-06	2	105	2	35177655
Pubmed	Collagen type IV-related nephropathies in Portugal: pathogenic COL4A3 and COL4A4 mutations and clinical characterization of 25 families.	COL4A3 COL4A4	9.03e-06	2	105	2	25307543
Pubmed	Genetic, Clinical, and Pathologic Backgrounds of Patients with Autosomal Dominant Alport Syndrome.	COL4A3 COL4A4	9.03e-06	2	105	2	27281700
Pubmed	[From Alport syndrome to benign familial hematuria: clinical and genetic aspect].	COL4A3 COL4A4	9.03e-06	2	105	2	16895672
Pubmed	Type-IV collagen related diseases.	COL4A3 COL4A4	9.03e-06	2	105	2	12768082
Pubmed	Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met.	MET PLXNB1	9.03e-06	2	105	2	20164843
Pubmed	Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in a Population Sequencing Database and Their Implications for Alport Syndrome.	COL4A3 COL4A5	9.03e-06	2	105	2	34400539
Pubmed	Possible Digenic Disease in a Caucasian Family with COL4A3 and COL4A5 Mutations.	COL4A3 COL4A5	9.03e-06	2	105	2	30661074
Pubmed	COL4A3/COL4A4 mutations producing focal segmental glomerulosclerosis and renal failure in thin basement membrane nephropathy.	COL4A3 COL4A4	9.03e-06	2	105	2	17942953
Pubmed	Polymorphisms in COL4A3 and COL4A4 genes associated with keratoconus.	COL4A3 COL4A4	9.03e-06	2	105	2	20029656
Interaction	RPS6KL1 interactions	MAP1B NUP98 NUP210 ALDH1A3 DYNC1H1	5.60e-06	51	101	5	int:RPS6KL1
Interaction	TRIM66 interactions	GNL3L DSG2 PEX1 TRIM66 PASK FAT1 CSMD1 GARRE1	8.99e-06	205	101	8	int:TRIM66
Interaction	SYNE3 interactions	NUP98 PEX1 PPP1R13B ITGB1 CEP350 C2CD3 BRCA2 NUP210 TMEM131L GARRE1 CEP97	1.40e-05	444	101	11	int:SYNE3
GeneFamily	Desmosomal cadherins	DSG2 DSG4	2.56e-04	7	64	2	1188
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MAP1B PPP1R13B RYR1 PCDH11X CSMD1	4.50e-04	181	64	5	694
GeneFamily	Collagens	COL4A3 COL4A4 COL4A5	5.76e-04	46	64	3	490
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ISLR CNTN6 LRFN2 CNTN3	2.54e-03	161	64	4	593
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000	CACNA1B MAPK8IP1 MAP1B DSG2 DOCK10 MET CADM1 ZFHX4 GLDC NUP210 PCDH11X CNTN3 CD74 ALDH1A3 CEP97 PLXNB1	1.22e-05	984	99	16	Facebase_RNAseq_e10.5_Olfactory Pit_1000
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 COL4A5 ABCA4 CNTN6 CADM1 AGER PCDH11X PLXNB1	1.03e-09	199	104	9	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	INCENP HEMGN ORC1 PASK CD7 CAPRIN2 SKA1 CEP97	5.02e-09	164	104	8	5621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ZAN SSPOP FAT1 ZFHX4 PCDH11X CSMD1 UNC80	1.24e-08	184	104	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ZAN SSPOP FAT1 ZFHX4 PCDH11X CSMD1 UNC80	1.24e-08	184	104	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ZAN SSPOP FAT1 ZFHX4 PCDH11X CSMD1 UNC80	1.24e-08	184	104	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	AT1-AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A4 ABCA4 DSG2 SPTB CNTN6 FAT1 ALDH1A3	9.20e-08	158	104	7	3bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL4A3 COL4A4 PPP1R13B CADM1 AGER OSBPL6 PLXNB1	1.24e-07	165	104	7	b9b6b7b8cd65ba6948a5dd8b715cc7092e0be637
ToppCell	droplet-Trachea-nan-3m-Myeloid-macrophage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 DOCK10 RYR1 ZNF263 CD7 NUP210 CD74	1.64e-07	172	104	7	f6c00a6a7e81aaf96c55eb3a3c88e3719f102ea0
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 DOCK10 RYR1 ZNF263 CD7 NUP210 CD74	1.64e-07	172	104	7	f3bbe3f069ad070778430d1a6cd9db0a76deb8de
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A3 COL4A4 COL4A5 ABCA4 CNTN6 CADM1 AGER	2.15e-07	179	104	7	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A3 COL4A4 COL4A5 ISLR SLC1A7 PCDH11X ALDH1A3	2.89e-07	187	104	7	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	COL4A5 ISLR CHKB SLC1A7 FAT1 TIMP2 ALDH1A3	3.58e-07	193	104	7	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 COL4A5 CNTN6 AGER PCDH11X PLXNB1	4.11e-07	197	104	7	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 ABCA4 CNTN6 CADM1 AGER PLXNB1	4.56e-07	200	104	7	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK10 RYR1 ZNF263 CD7 NUP210 CD74	3.08e-06	171	104	6	87cb65648c663e246f94cea1a5ed12e8e29ec629
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 COL4A4 ABCA4 GAS7 MET ALDH1A3	3.40e-06	174	104	6	46bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	INCENP GAS7 BRCA2 NUP210 CD74 CEP97	3.52e-06	175	104	6	f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCell	AT1_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 COL4A4 CHKB CNTN6 CADM1 AGER	3.63e-06	176	104	6	4a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 IFNLR1 CADM1 AGER	3.88e-06	178	104	6	a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 IFNLR1 CADM1 AGER	3.88e-06	178	104	6	b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.01e-06	179	104	6	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	AT1_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 COL4A4 CNTN6 CADM1 AGER PLXNB1	4.01e-06	179	104	6	1603117b52623663458a977c94bf7f9f6c1114b8
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.27e-06	181	104	6	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.69e-06	184	104	6	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 DOCK10 GAS7 CADM1 PIK3R6 CD74	4.69e-06	184	104	6	4f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.69e-06	184	104	6	561592edc3083fad41b91811151b442207c65dd9
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.69e-06	184	104	6	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.84e-06	185	104	6	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB GAS7 CADM1 CSMD1 UNC80 PLXNB1	4.84e-06	185	104	6	11c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	4.99e-06	186	104	6	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 COL4A4 CHKB CNTN6 CADM1 AGER	5.15e-06	187	104	6	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	5.15e-06	187	104	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	5.15e-06	187	104	6	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A3 COL4A4 COL4A5 DSG2 TIMP2 AGER	5.15e-06	187	104	6	ff26a533d310126521efe1d05cf8b9d32e524550
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	5.15e-06	187	104	6	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	Control-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	COL4A3 COL4A4 CNTN6 CADM1 TIMP2 AGER	5.15e-06	187	104	6	3a032432f780525f4f4c2a358897d9989b1ecae7
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B GAS7 ISLR ZFHX4 TIMP2 ALDH1A3	5.31e-06	188	104	6	c32d023a69b6da79687ff8fa7485e7499db57046
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL4A3 COL4A4 PRAG1 CNTN6 CADM1 AGER	5.31e-06	188	104	6	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B GAS7 ISLR ZFHX4 TIMP2 ALDH1A3	5.31e-06	188	104	6	1cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCell	COPD-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	COL4A3 COL4A4 CNTN6 CADM1 TIMP2 AGER	5.47e-06	189	104	6	14e8e57e4db336fbef005270647983b4edf407c0
ToppCell	PND10-Epithelial-Epithelial_Alveolar\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 MET CADM1 AGER CD74	5.64e-06	190	104	6	dc20d323cee2741e39fba597263d6418ae0eadaf
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 MET CADM1 AGER CD74	5.64e-06	190	104	6	ec1bd4929dc82bec2c983a31ece4e3aa82f3a2ab
ToppCell	COVID-19-kidney-Proliferating_T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK2 HEMGN ORC1 BRCA2 NUP210 SKA1	5.81e-06	191	104	6	bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 CADM1 AGER OSBPL6	5.81e-06	191	104	6	ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 CADM1 AGER OSBPL6	5.81e-06	191	104	6	c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCell	PND03-Epithelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 CADM1 AGER OSBPL6	5.99e-06	192	104	6	d8c23693f690d4d568585537bbfedda05d505b3d
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 IFNLR1 CADM1 AGER	5.99e-06	192	104	6	790282d4232311df3dac4ad97c80fc53443beccc
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A3 COL4A4 COL4A5 IFNLR1 CADM1 AGER	5.99e-06	192	104	6	b2d9bffccd6264b4f12d88a0780646ee0b41969f
ToppCell	Epithelial\|World / shred on cell class and cell subclass (v4)	COL4A3 COL4A4 PPP1R13B CADM1 AGER OSBPL6	5.99e-06	192	104	6	13a3553d9a7c78535679d23d454c63fd08f7d218
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A5 DSG2 MET FAT1 TIMP2 PLXNB1	5.99e-06	192	104	6	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 CNTN6 ZFHX4 BRCA2 AGER	6.05e-06	110	104	5	c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	6.54e-06	195	104	6	a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell	AT1_cells\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 COL4A4 CHKB CNTN6 CADM1 AGER	6.54e-06	195	104	6	792d6a49b0a875a00569071183d195287a9925c5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 DOCK10 GAS7 RYR1 PIK3R6 CD74	6.54e-06	195	104	6	09df40ff9b493170861b3f6e57a942a834655b5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 MET FAT1 CADM1 ZFHX4 CRYBG1	6.74e-06	196	104	6	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	DOCK10 ITGB1 CEP350 CADM1 PBRM1 ZNF292	6.74e-06	196	104	6	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	Epithelial-A_(AT1)\|World / shred on cell class and cell subclass (v4)	COL4A3 COL4A4 COL4A5 PPP1R13B CADM1 AGER	6.74e-06	196	104	6	484bbc6b1f58bc260964babb949d14f5df101393
ToppCell	Epithelial-Epithelial-A_(AT1)\|Epithelial / shred on cell class and cell subclass (v4)	COL4A3 COL4A4 ITGB1 CADM1 TIMP2 AGER	6.74e-06	196	104	6	41b21a18125cc95bc8adde3369e4abd029cf137d
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 COL4A5 AGER PCDH11X PLXNB1	6.94e-06	197	104	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	6.94e-06	197	104	6	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	AT1_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 COL4A4 CHKB CNTN6 CADM1 AGER	6.94e-06	197	104	6	80d81be244c94c435accb643449b4ce6a3462c7f
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 COL4A4 DSG2 CHKB CADM1 AGER	7.14e-06	198	104	6	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.14e-06	198	104	6	54228dd9a50616d2022712d162a419ed0327cabd
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 CNTN6 CADM1 AGER PLXNB1	7.14e-06	198	104	6	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B MAP1B PCDH11X OSBPL6 CSMD1 UNC80	7.14e-06	198	104	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 COL4A3 COL4A4 DOCK10 NUP210 CD74	7.14e-06	198	104	6	824461cf44098440ba8bc0df96735423ac65bda1
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 ABCA4 CNTN6 AGER PLXNB1	7.14e-06	198	104	6	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 COL4A3 COL4A4 DOCK10 NUP210 CD74	7.14e-06	198	104	6	863765ccc0205dc28864dae85af339c283194c96
ToppCell	medial-2-Epithelial-Alveolar_Epithelial_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.35e-06	199	104	6	456460c761e26ed4b1d88d9bee4d2a7c9bd9d416
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.35e-06	199	104	6	5263338242f95c04690d0795749ccc20b0d19f7a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 CNTN6 CADM1 AGER PLXNB1	7.35e-06	199	104	6	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 CNTN6 CADM1 AGER PLXNB1	7.35e-06	199	104	6	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.35e-06	199	104	6	f8846446ebbc4948cdc69640782db1358bbdc486
ToppCell	Parenchyma_COVID-19-Epithelial-TX-AT1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.35e-06	199	104	6	fe9f5bc317be0c35bd96311bf0b3c7b91d98acc5
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A3 COL4A4 DSG2 MET CADM1 AGER	7.35e-06	199	104	6	a38a981cffa61c8444a980916de7414e689a1b63
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.35e-06	199	104	6	c11365653c69a5dfb37946231f8af05149a61a71
ToppCell	ILEUM-non-inflamed-(8)_Smooth_muscle_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	COL4A5 MAP1B CHKB SLC1A7 FAT1 TIMP2	7.35e-06	199	104	6	3368c0a90a47c4dcdfe70be3192550df0744e508
ToppCell	control-unassigned\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PADI4 PPP1R13B PIK3R6 AGER KBTBD12 GARRE1	7.35e-06	199	104	6	5db7c8089172ac8e796613b3cef618d87007a0ab
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL4A3 COL4A4 DSG2 CNTN6 CADM1 AGER	7.35e-06	199	104	6	3e35ee426ef06f9af568c37349b62dd1ee9b97ea
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	COL4A4 DSG2 MET FAT1 ALDH1A3 PLXNB1	7.56e-06	200	104	6	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 COL4A5 CNTN6 AGER PLXNB1	7.56e-06	200	104	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	distal-2-Epithelial-Alveolar_Epithelial_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	7.56e-06	200	104	6	313ec1e53bd738a9cb48dc5b946261156f99f44b
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL4A3 COL4A4 CNTN6 CADM1 AGER PLXNB1	7.56e-06	200	104	6	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Biopsy_Other_PF-Epithelial-AT1\|Biopsy_Other_PF / Sample group, Lineage and Cell type	COL4A3 COL4A4 COL4A5 CNTN6 CADM1 AGER	7.56e-06	200	104	6	b746dcc94814bcbca63c71e6451a9c5f084bcfaf
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEMGN RYR1 NUP210 TMEM131L CD74	1.95e-05	140	104	5	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 COL4A4 ABCA4 ZFHX4 ALDH1A3	2.31e-05	145	104	5	8da10bc6611976e1ec85e09f04a2dc5bf6555c9e
ToppCell	Epithelial-B_(AT1-AT2-progenitors)\|World / shred on cell class and cell subclass (v4)	COL4A3 COL4A4 PPP1R13B CADM1 AGER	2.39e-05	146	104	5	4511916904c1fac252cb68e871b782207f8137b3
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL4A3 COL4A4 COL4A5 CADM1 AGER	2.72e-05	150	104	5	6a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 COL4A4 COL4A5 ABCA4 ALDH1A3	2.80e-05	151	104	5	16fc903fc71e25717b9908416f0bcd29c0a65a61
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 CADM1 CD7 NUP210 CD74	3.28e-05	156	104	5	5d97755db872d51522f6412a93704f3c79a084cd
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PRAG1 RYR1 MET ZFHX4 ALDH1A3	3.28e-05	156	104	5	2cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK2 CEP350 ORC1 CD7 PTCH2	3.70e-05	160	104	5	b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK2 CEP350 ORC1 CD7 PTCH2	3.70e-05	160	104	5	9caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	COL4A3 COL4A4 CNTN6 AGER ALDH1A3	3.70e-05	160	104	5	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK2 CEP350 ORC1 CD7 PTCH2	3.70e-05	160	104	5	229841be7b984a00a301cd5d88c11226a90d8a88
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK2 CEP350 ORC1 CD7 PTCH2	3.70e-05	160	104	5	99c9ae2041445539fada842e1af01368669bfca0
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B ZAN CNTN6 CNTN3 UNC80	3.92e-05	162	104	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	PADI4 HEMGN ISLR MET ALDH1A3	4.04e-05	163	104	5	1a8c79903ed416f286ebe8a9922233affbc55d82
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A3 COL4A4 ORC1 AGER CFAP61	4.16e-05	164	104	5	cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A3 COL4A4 ORC1 AGER CFAP61	4.16e-05	164	104	5	5dbfcdd450f652b16d97da53b528d4584b0eabcf
Drug	Adamantamine fumarate [80789-67-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	HFE NUP98 GAS7 ITGB1 INO80D SLC1A7 PASK SKA1 PLXNB1 ZNF292	2.65e-08	199	104	10	4806_DN
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A	MTHFSD GNL3L NUP98 MET LINS1 CAPRIN2 CEP97 ZNF292	3.58e-06	198	104	8	3424_DN
Drug	HepIII	COL4A3 COL4A5 ITGB1 TIMP2	6.65e-06	27	104	4	CID003036270
Drug	Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A	COL4A5 DSG2 ITGB1 MET PASK FAT1 NUP210	7.23e-06	155	104	7	6817_DN
Drug	Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A	COL4A5 DSG2 ITGB1 FAT1 CADM1 NUP210 TMEM131L	9.27e-06	161	104	7	3556_DN
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A	HFE GNL3L INCENP HLCS ZKSCAN5 SLC1A7 MET	2.80e-05	191	104	7	4981_DN
Drug	MS-275; Down 200; 10uM; PC3; HT_HG-U133A	ASXL1 ORC1 MET ZNF263 BRCA2 ZFYVE26 CRBN	2.99e-05	193	104	7	7084_DN
Drug	Doxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	HFE MAP1B CAMTA2 ZKSCAN5 MET SKA1 GARRE1	2.99e-05	193	104	7	3479_DN
Drug	Mafenide hydrochloride [138-37-4]; Down 200; 18uM; HL60; HG-U133A	HFE CDIP1 NUP98 GAS7 INO80D NUP210 ENG	3.20e-05	195	104	7	1441_DN
Drug	SR-95639A [115767-94-7]; Up 200; 10uM; MCF7; HT_HG-U133A	HFE MAP1B INCENP INO80D RYR1 MET ZFHX4	3.20e-05	195	104	7	3272_UP
Drug	Tenoxicam [59804-37-4]; Up 200; 11.8uM; HL60; HT_HG-U133A	COL4A3 HLCS SPART PPP1R13B ITGB1 PASK ENG	3.20e-05	195	104	7	2501_UP
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; MCF7; HT_HG-U133A	MTHFSD ASXL1 INCENP CADM1 RANGRF NUP210 ZNF292	3.30e-05	196	104	7	7027_DN
Drug	Propafenone hydrochloride [34183-22-7]; Up 200; 10.6uM; MCF7; HT_HG-U133A	COL4A3 HFE CDIP1 GNL3L SPTB GAS7 PBRM1	3.30e-05	196	104	7	2871_UP
Drug	AH23848 hemicalcium salt hydrate; Up 200; 1uM; MCF7; HT_HG-U133A	HFE COL4A5 MAP1B HLCS GAS7 TRIM66 CADM1	3.41e-05	197	104	7	6890_UP
Drug	N6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Up 200; 2uM; MCF7; HT_HG-U133A_EA	ASXL1 INCENP HLCS ZKSCAN5 MET TRIM66 GARRE1	3.53e-05	198	104	7	842_UP
Drug	Bacampicillin hydrochloride [37661-08-8]; Up 200; 8uM; PC3; HT_HG-U133A	COL4A3 HFE HLCS GAS7 SLC1A7 MET ENG	3.64e-05	199	104	7	4592_UP
Drug	Atracurium besylate [64228-81-5]; Up 200; 3.2uM; MCF7; HT_HG-U133A	HFE INO80D MET PASK GSTCD CEP97 PLXNB1	3.64e-05	199	104	7	7477_UP
Drug	phenyltin	CBLIF PACS2 ENG	6.01e-05	17	104	3	CID006335496
Drug	CP-331	COL4A3 COL4A5	6.18e-05	3	104	2	CID000130967
Disease	Alport syndrome	COL4A3 COL4A4 COL4A5	4.13e-08	3	103	3	cv:C1567741
Disease	Collagen IV-related nephropathies	COL4A3 COL4A4 COL4A5	4.13e-08	3	103	3	cv:CN076135
Disease	Hematuria, Benign Familial	COL4A3 COL4A4 COL4A5	1.65e-07	4	103	3	C0241908
Disease	Alport Syndrome	COL4A3 COL4A4 COL4A5	1.65e-07	4	103	3	C1567741
Disease	Alport Syndrome, X-Linked	COL4A3 COL4A4 COL4A5	4.11e-07	5	103	3	C1567742
Disease	Alport Syndrome, Autosomal Dominant	COL4A3 COL4A4 COL4A5	4.11e-07	5	103	3	C1567743
Disease	Alport Syndrome, Autosomal Recessive	COL4A3 COL4A4 COL4A5	4.11e-07	5	103	3	C1567744
Disease	collagen disease (implicated_via_orthology)	COL4A3 COL4A4 COL4A5	8.88e-06	12	103	3	DOID:854 (implicated_via_orthology)
Disease	Alport syndrome, recessive type	COL4A3 COL4A4	1.21e-05	2	103	2	C2931254
Disease	Alport syndrome, dominant type	COL4A3 COL4A4	1.21e-05	2	103	2	C2931253
Disease	autosomal recessive Alport syndrome (is_implicated_in)	COL4A3 COL4A4	1.21e-05	2	103	2	DOID:0110033 (is_implicated_in)
Disease	Thin basement membrane disease	COL4A3 COL4A4	1.21e-05	2	103	2	C0403440
Disease	benign familial hematuria (is_implicated_in)	COL4A3 COL4A4	1.21e-05	2	103	2	DOID:0111365 (is_implicated_in)
Disease	ALPORT SYNDROME 2, AUTOSOMAL RECESSIVE	COL4A3 COL4A4	1.21e-05	2	103	2	C4746745
Disease	Benign familial hematuria	COL4A3 COL4A4	1.21e-05	2	103	2	cv:C0241908
Disease	autosomal recessive Alport syndrome (implicated_via_orthology)	COL4A3 COL4A4	3.61e-05	3	103	2	DOID:0110033 (implicated_via_orthology)
Disease	Alport syndrome (is_implicated_in)	COL4A3 COL4A5	3.61e-05	3	103	2	DOID:10983 (is_implicated_in)
Disease	Renal glomerular disease	COL4A3 COL4A4 COL4A5	6.95e-05	23	103	3	C0268731
Disease	Glomerulopathy Assessment	COL4A3 COL4A4 COL4A5	6.95e-05	23	103	3	C4521256
Disease	hypertensive nephropathy	COL4A3 COL4A4	1.79e-04	6	103	2	C0848548
Disease	MEDULLOBLASTOMA	BRCA2 PTCH2	1.79e-04	6	103	2	155255
Disease	Medulloblastoma	BRCA2 PTCH2	1.79e-04	6	103	2	cv:C0025149
Disease	obesity	NUP98 PRAG1 INO80D TRIM66 FAT1 ZZZ3	2.06e-04	241	103	6	EFO_0001073
Disease	myelofibrosis (is_implicated_in)	HFE ASXL1	3.33e-04	8	103	2	DOID:4971 (is_implicated_in)
Disease	albuminuria	COL4A3 COL4A4 CADM1 CSMD1	3.36e-04	94	103	4	EFO_0004285
Disease	Glioma	BRCA2 PTCH2	4.28e-04	9	103	2	cv:C0017638
Disease	Hematuria	COL4A5 CFHR5	4.28e-04	9	103	2	C0018965
Disease	medulloblastoma (is_implicated_in)	BRCA2 PTCH2	5.33e-04	10	103	2	DOID:0050902 (is_implicated_in)
Disease	myopathy (implicated_via_orthology)	COL4A3 COL4A4 COL4A5	6.37e-04	48	103	3	DOID:423 (implicated_via_orthology)
Disease	Colorectal Carcinoma	CCDC9B ABCA4 MAP1B ISLR SLC1A7 FAT1 ZZZ3 PCDH11X ZNF292	7.98e-04	702	103	9	C0009402
Disease	intracranial aneurysm (biomarker_via_orthology)	TIMP2 AGER	9.18e-04	13	103	2	DOID:10941 (biomarker_via_orthology)
Disease	Adenocarcinoma Of Esophagus	DOCK2 SPART	1.07e-03	14	103	2	C0279628
Disease	Malignant neoplasm of breast	ABCA4 NUP98 HLCS CFHR5 CNTN6 CADM1 PBRM1 BRCA2 CD74 ZFYVE26 PLXNB1	1.33e-03	1074	103	11	C0006142
Disease	renal fibrosis (implicated_via_orthology)	AGER ENG	1.59e-03	17	103	2	DOID:0050855 (implicated_via_orthology)
Disease	MHPG measurement, 5-HIAA measurement	COL4A3 CADM1	1.59e-03	17	103	2	EFO_0005132, EFO_0005133
Disease	Microcephaly	ORC1 DYNC1H1 ZNF292	1.68e-03	67	103	3	C0025958
Disease	MYELODYSPLASTIC SYNDROME	HFE ASXL1 BRCA2	1.68e-03	67	103	3	C3463824
Disease	melanoma	INCENP MET BRCA2 CRYBG1 ALDH1A3	1.81e-03	248	103	5	C0025202
Disease	Prostate cancer, familial	DOCK2 INCENP BRCA2	1.83e-03	69	103	3	C2931456
Disease	Autistic Disorder	MET PASK CADM1 CNTN3 ZNF292	2.26e-03	261	103	5	C0004352
Disease	periodontitis (biomarker_via_orthology)	MET AGER	2.43e-03	21	103	2	DOID:824 (biomarker_via_orthology)
Disease	diastolic blood pressure, systolic blood pressure	CDIP1 MAP1B CEP350 MET C2CD3 MALRD1 SLC7A6OS OSBPL6	2.43e-03	670	103	8	EFO_0006335, EFO_0006336
Disease	epilepsy (implicated_via_orthology)	CACNA1B CHKB SLC1A7 DYNC1H1	2.60e-03	163	103	4	DOID:1826 (implicated_via_orthology)
Disease	sensory peripheral neuropathy, remission	GAS7 CSMD1	2.91e-03	23	103	2	EFO_0009785, MONDO_0002321
Disease	Neoplasm of the genitourinary tract	MET BRCA2	3.17e-03	24	103	2	cv:C0042065
Disease	nighttime rest measurement	HLCS CSMD1	3.17e-03	24	103	2	EFO_0007827
Disease	airway responsiveness measurement	CAPRIN2 CSMD1	3.17e-03	24	103	2	EFO_0006897
Disease	breast cancer (implicated_via_orthology)	MET BRCA2	3.44e-03	25	103	2	DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IVVEPSPVQQIAHLC	nan	196	Q6ZRG5
PVCPADLVIDHSIQV	ACO1	116	P21399
QVPCPTEADISQHLT	CFAP61	776	Q8NHU2
AQEVQQSPHCTTVPV	CD7	26	P09564
APVQTVCPHCQQAIT	CDIP1	136	Q9H305
IQTECIPHACRQPET	CSMD1	3266	Q96PZ7
IAIAVHSQTTDIPPC	COL4A3	1556	Q01955
TTCPAHVDDLTPEQV	ABCA4	1186	P78363
EHPSEVQHECIPQAI	DDX39B	66	Q13838
HPSEVQHECIPQAIL	DDX39A	66	O00148
QVEPLPSHLCITIAI	GUSBP11	161	Q6P575
ITIAINNTLTPQPCH	GUSBP11	171	Q6P575
IPTDDNVVCFTRHEP	ALDH1A3	156	P47895
VAVHSQDQSIPPCPQ	COL4A4	1576	P53420
CVFDHIAVPASLVQP	CAMTA2	566	O94983
TLHDDDSCQVIPVLP	CRBN	71	Q96SW2
STPSPVVFCHNDIQE	CHKB	231	Q9Y259
LVCQHQGQPPTLDIE	CFAP73	261	A6NFT4
HTLPSTCLQKVEEQP	CACNA1B	1041	Q00975
PTSLAETVHCDLQPV	ENG	21	P17813
PEELICPQTTHQTAE	PPP1R13B	801	Q96KQ4
VEQPQLHPDVRTECE	ASXL1	776	Q8IXJ9
TLTCEVPAQPSPQIH	AGER	256	Q15109
NEVMVHVVENPECPT	ITGB1	711	P05556
VPDNQEVFCHPVTDQ	RANGRF	31	Q9HD47
CPTLIEPVQTICHDA	DSG2	496	Q14126
LIRVTPEQPTHAVCV	PADI4	6	Q9UM07
ECTPTQREVIQALHP	NUP210	1591	Q8TEM1
TVHVIDINDCPPVFA	FAT1	1866	Q14517
STVHVDELCPLIVPN	NUP98	1226	P52948
VEPAEANLQPHIVCI	PBRM1	966	Q86U86
DVPHAELVPTECQAV	PASK	676	Q96RG2
EVQPECELITSPDHV	LINS1	366	Q8NG48
PVSPEVTQEVVEEHC	MAP1B	1296	P46821
PVQITLQPAASEHHC	IFNLR1	181	Q8IU57
PEDNHTQCQLVPVVE	INCENP	156	Q9NQS7
CNPLTITVHDPNAAQ	ERVS71-1	186	P61550
VHFNPPSSCVLEISV	MAPK8IP1	601	Q9UQF2
CQVHLELPPSSNIVQ	HLCS	331	P50747
ICLNTEIEPFPSHQA	DSG4	846	Q86SJ6
HQAELEVQTCPEPQR	CCDC9B	466	Q6ZUT6
SIPEQDNIACTSPHV	ISLR	201	O14498
EAVATQCPAPLIHSV	PLXNB1	1061	O43157
VAVCNPLHDSTVLTP	OR51G1	126	Q8NGK1
SCLLPVQVVTEHPLE	PCDHGC5	101	Q9Y5F6
TCQVEHPGLDQPLIV	HFE	281	Q30201
QTIALCHSPPVTQTI	PCDH11X	1191	Q9BZA7
HTLPVVCTCSPADVQ	PACS2	511	Q86VP3
CDQVVSVNIIPSPDE	OSBPL6	451	Q9BZF3
SPNTCQVISVIQDHP	HEMGN	201	Q9BXL5
HVSAVPESLPCREQE	ORC1	496	Q13415
VPVTLPPHNCTDNEF	MALRD1	1041	Q5VYJ5
VPVICQVEHPAVTGN	CADM1	216	Q9BY67
AVLPHVDQVTLCDIP	ICE1	1431	Q9Y2F5
LDVPQVTCSPDHEVQ	CBLIF	281	P27352
EVQLSPPEVISCHQK	C2CD3	1591	Q4AC94
VDNVPLEHPNCVTSS	DOCK10	621	Q96BY6
IQCFTVQPVLDEHPR	DOCK2	1406	Q92608
TCPHHVPVQVEQDEE	SLC1A7	526	O00341
ESPVVLQCTHVTPQR	BRCA2	141	P51587
VCPPNHVVSLTNNLI	GJA9	491	P57773
IPEHSSPVQDCQISQ	CEP97	326	Q8IW35
QCELPTVPVQIGSHF	GARRE1	336	O15063
VCEAPAVVIAVHSQT	COL4A5	1566	P29400
TQQPCETLLAVPHTA	CEP350	2906	Q5VT06
SIVLPCQVSHDPSIE	CNTN6	516	Q9UQ52
TPPQCQLPSIHVEQT	CAPRIN2	801	Q6IMN6
ECHVPILEANVDAQP	CFHR5	146	Q9BXR6
QQCSVPVFDITHQTP	INO80D	491	Q53TQ3
PPSHREAIVNSCVFV	DYNC1H1	3136	Q14204
TKCQEEVSHIPAVHP	CD74	211	P04233
VQLPTCHSNEPEVVS	CRYBG1	576	Q9Y4K1
SHTDFVPCPVDTVQI	RYR1	846	P21817
LTTSTEQHPNLCEVP	GSTCD	346	Q8NEC7
PCSHVVSCQQVEVEP	PEX1	96	O43933
VSVGESVILPCQVQH	CNTN3	511	Q9P232
PLPLQLACHAVVTVN	KBTBD12	421	Q3ZCT8
EPECPVCHTAVTQAI	MEX3B	551	Q6ZN04
SEVHCIFSPQIEEPS	MET	156	P08581
VPSHLPQVTVTQSCV	SKA1	91	Q96BD8
TEPVVLPVIHSCQCS	SSPOP	5126	A2VEC9
LSNSHPVEESIIIPC	TRAFD1	356	O14545
ENGVPCVIQESAPVH	TMEM131L	1426	A2VDJ0
QLICLVQEPHSAPAV	TAB3	116	Q8N5C8
ENTITINCVTFPHPD	GAS7	171	O60861
NCVHVQKLADPVTPV	GNL3L	321	Q9NVN8
CEASSQHVVTILPPQ	PTCH2	606	Q9Y6C5
PAAPVTDHTCLNVNV	PIK3R6	636	Q5UE93
HLVATVCSQEEPVQP	SLC7A6OS	56	Q96CW6
EVNLSHIVPCEPVPE	SPART	396	Q8N0X7
VLSQHSVQPVICCPL	ZFHX4	1191	Q86UP3
CDIPTQLPVHEDTQF	UNC80	2006	Q8N2C7
PVVTIVHDCQVVDIP	MTHFSD	176	Q2M296
PVHPQQAFCNADVVI	TIMP2	31	P16035
TTNLHSNVIPTCEPQ	ZNF292	1666	O60281
QPCDPQVIQDRISHL	SPTB	601	P11277
LNLAVPIHSCEVQPT	nan	126	Q6ZUG5
LPTHPPAQEQDCVVV	PRAG1	1076	Q86YV5
EILVEPVTLPCNHTL	RNF168	21	Q8IYW5
ENVLLPCSQHTPEIS	ZNF792	591	Q3KQV3
VCIVPPQDVQQGAHA	TRIM66	411	O15016
CLPVEHVNQLTTEPA	ZZZ3	286	Q8IYH5
VDAPVPEHLSQCQNL	ZFYVE26	481	Q68DK2
VQESCSPHPLTVDTQ	ZKSCAN5	156	Q9Y2L8
HQTVAPEPFQEHCVL	ZAN	2561	Q9Y493
VPSVCSENIHPQVLL	ZNF263	306	O14978
VDPRCHPQTIAVVQT	GLDC	221	P23378
EEEFVCEPPLITQHT	LRFN2	281	Q9ULH4