Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acidic amino acid transmembrane transporter activity	SLC25A13 GRIK1 SLC1A5	8.34e-05	20	86	3	GO:0015172
GeneOntologyMolecularFunction	channel activity	GABRG2 CLCN1 MLC1 KCNJ5 GRIK1 PKD1L3 SLC1A5 SLC12A5 GABRA4	4.28e-04	525	86	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GABRG2 CLCN1 MLC1 KCNJ5 GRIK1 PKD1L3 SLC1A5 SLC12A5 GABRA4	4.34e-04	526	86	9	GO:0022803
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GABRG2 TAPT1 PIGR UNC5B OR1Q1 OR4C46 GRIK1 TACR1 OR6C6 PKD1L3 GRM6 ADGRG4 OR6M1 OR52B6 GABRA4	6.14e-04	1353	86	15	GO:0004888
GeneOntologyMolecularFunction	L-aspartate transmembrane transporter activity	SLC25A13 SLC1A5	8.07e-04	10	86	2	GO:0015183
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRG2 GABRA4	9.83e-04	11	86	2	GO:0008503
GeneOntologyMolecularFunction	transporter activity	GABRG2 CEACAM5 CLCN1 MLC1 KCNJ5 SLC25A13 ATP9B GRIK1 STRA6 PKD1L3 SLC9C2 SLC1A5 SLC12A5 GABRA4	1.16e-03	1289	86	14	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	GABRG2 CEACAM5 CLCN1 MLC1 KCNJ5 SLC25A13 GRIK1 STRA6 PKD1L3 SLC9C2 SLC1A5 SLC12A5 GABRA4	1.56e-03	1180	86	13	GO:0022857
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRG2 KCNJ5 GRIK1 SLC1A5 GABRA4	1.62e-03	197	86	5	GO:0022834
GeneOntologyMolecularFunction	C4-dicarboxylate transmembrane transporter activity	SLC25A13 SLC1A5	1.86e-03	15	86	2	GO:0015556
GeneOntologyMolecularFunction	L-glutamate transmembrane transporter activity	SLC25A13 GRIK1	1.86e-03	15	86	2	GO:0005313
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRG2 GRIK1 GABRA4	1.91e-03	57	86	3	GO:1904315
GeneOntologyMolecularFunction	protein kinase A binding	NBEA LRBA RAB13	2.01e-03	58	86	3	GO:0051018
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	GABRG2 CLCN1 SLC12A5 GABRA4	2.09e-03	125	86	4	GO:0015108
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	GABRG2 CLCN1 MLC1 KCNJ5 SLC25A13 GRIK1 PKD1L3 SLC9C2 SLC12A5 GABRA4	2.14e-03	793	86	10	GO:0015075
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GABRG2 GRIK1 GABRA4	2.21e-03	60	86	3	GO:0099529
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRG2 GABRA4	2.68e-03	18	86	2	GO:0022851
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRG2 GRIK1 GABRA4	2.78e-03	65	86	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRG2 GRIK1 GABRA4	2.78e-03	65	86	3	GO:0022824
GeneOntologyBiologicalProcess	monoatomic ion transport	GABRG2 RELN CLCN1 NFATC1 MLC1 KCNJ5 AHNAK SLC25A13 XCL2 LMTK2 GRIK1 PKD1L3 GRM6 XCL1 SLC9C2 CLDN10 WNK4 SLC12A5 GABRA4	2.01e-06	1374	84	19	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	GABRG2 RELN CLCN1 MLC1 KCNJ5 AHNAK SLC25A13 XCL2 GRIK1 PKD1L3 GRM6 XCL1 SLC9C2 WNK4 SLC12A5 GABRA4	9.43e-06	1115	84	16	GO:0034220
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	GABRG2 CLCN1 ANK1 KCNJ5 AHNAK SLC25A13 XCL2 GRIK1 PKD1L3 GRM6 XCL1 SLC9C2 WNK4 SLC12A5 GABRA4	1.35e-05	1017	84	15	GO:0098660
GeneOntologyBiologicalProcess	mature natural killer cell chemotaxis	XCL2 XCL1	1.64e-05	2	84	2	GO:0035782
GeneOntologyBiologicalProcess	regulation of B cell chemotaxis	XCL2 XCL1	4.90e-05	3	84	2	GO:2000537
GeneOntologyBiologicalProcess	positive regulation of B cell chemotaxis	XCL2 XCL1	4.90e-05	3	84	2	GO:2000538
GeneOntologyBiologicalProcess	positive regulation of immunoglobulin production in mucosal tissue	XCL2 XCL1	4.90e-05	3	84	2	GO:2000558
GeneOntologyBiologicalProcess	regulation of immunoglobulin production in mucosal tissue	XCL2 XCL1	4.90e-05	3	84	2	GO:2000557
GeneOntologyBiologicalProcess	localization within membrane	RAB35 RELN ANK1 PIGR NSG1 RAPGEF4 LMTK2 NBEA FYB1 GDI1 RAB13 WNK4	9.06e-05	798	84	12	GO:0051668
GeneOntologyBiologicalProcess	positive regulation of thymocyte migration	XCL2 XCL1	1.63e-04	5	84	2	GO:2000412
GeneOntologyBiologicalProcess	immunoglobulin production in mucosal tissue	XCL2 XCL1	1.63e-04	5	84	2	GO:0002426
GeneOntologyBiologicalProcess	chloride transport	GABRG2 CLCN1 WNK4 SLC12A5 GABRA4	1.77e-04	128	84	5	GO:0006821
GeneOntologyBiologicalProcess	synaptic transmission, GABAergic	GABRG2 GRIK1 TACR1 GABRA4	2.37e-04	74	84	4	GO:0051932
GeneOntologyBiologicalProcess	regulation of thymocyte migration	XCL2 XCL1	2.43e-04	6	84	2	GO:2000410
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	KCNJ5 GRM6 SLC9C2 WNK4 SLC12A5	2.88e-04	142	84	5	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	KCNJ5 GRM6 SLC9C2 WNK4 SLC12A5	2.88e-04	142	84	5	GO:0098659
GeneOntologyBiologicalProcess	positive regulation of natural killer cell chemotaxis	XCL2 XCL1	3.40e-04	7	84	2	GO:2000503
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	ANK1 KCNJ5 AHNAK SLC25A13 XCL2 GRIK1 PKD1L3 GRM6 XCL1 SLC9C2 WNK4 SLC12A5	3.45e-04	922	84	12	GO:0098662
GeneOntologyBiologicalProcess	import across plasma membrane	KCNJ5 GRM6 SLC9C2 SLC1A5 WNK4 SLC12A5	3.55e-04	230	84	6	GO:0098739
GeneOntologyBiologicalProcess	regulation of membrane potential	GABRG2 RELN CLCN1 NRCAM KCNJ5 RAPGEF4 GRIK1 TACR1 GABRA4	4.48e-04	559	84	9	GO:0042391
GeneOntologyBiologicalProcess	cell junction organization	GABRG2 RELN CDH26 CEACAM5 NRCAM TNC RAPGEF4 NBEA GRM6 CLDN10 RAB13 GABRA4	5.64e-04	974	84	12	GO:0034330
GeneOntologyBiologicalProcess	protein localization to membrane	RELN ANK1 PIGR NSG1 RAPGEF4 NBEA FYB1 GDI1 RAB13 WNK4	5.77e-04	705	84	10	GO:0072657
GeneOntologyBiologicalProcess	thymocyte migration	XCL2 XCL1	5.79e-04	9	84	2	GO:0072679
GeneOntologyBiologicalProcess	regulation of T-helper 1 cell cytokine production	XCL2 XCL1	5.79e-04	9	84	2	GO:2000554
GeneOntologyBiologicalProcess	positive regulation of T-helper 1 cell cytokine production	XCL2 XCL1	5.79e-04	9	84	2	GO:2000556
GeneOntologyBiologicalProcess	B cell chemotaxis	XCL2 XCL1	5.79e-04	9	84	2	GO:0035754
GeneOntologyBiologicalProcess	endocytic recycling	RAB35 NSG1 LMTK2 RAB13	6.15e-04	95	84	4	GO:0032456
GeneOntologyBiologicalProcess	metal ion transport	NFATC1 KCNJ5 AHNAK XCL2 LMTK2 GRIK1 PKD1L3 GRM6 XCL1 SLC9C2 WNK4 SLC12A5	7.11e-04	1000	84	12	GO:0030001
GeneOntologyBiologicalProcess	regulation of natural killer cell chemotaxis	XCL2 XCL1	7.22e-04	10	84	2	GO:2000501
GeneOntologyBiologicalProcess	positive regulation of T-helper 2 cell cytokine production	XCL2 XCL1	7.22e-04	10	84	2	GO:2000553
GeneOntologyBiologicalProcess	receptor localization to synapse	RELN NSG1 RAPGEF4 NBEA	7.74e-04	101	84	4	GO:0097120
GeneOntologyBiologicalProcess	monoatomic cation transport	NFATC1 KCNJ5 AHNAK SLC25A13 XCL2 LMTK2 GRIK1 PKD1L3 GRM6 XCL1 SLC9C2 WNK4 SLC12A5	7.76e-04	1157	84	13	GO:0006812
GeneOntologyCellularComponent	recycling endosome	RAB35 PIGR MLC1 NSG1 LMTK2 RAB11FIP5 RAB13	3.94e-05	222	87	7	GO:0055037
GeneOntologyCellularComponent	postsynaptic membrane	GABRG2 ANK1 NRCAM NSG1 NBEA GRIK1 GRM6 SLC12A5 GABRA4	4.76e-05	405	87	9	GO:0045211
GeneOntologyCellularComponent	recycling endosome membrane	RAB35 PIGR NSG1 RAB11FIP5 RAB13	1.05e-04	112	87	5	GO:0055038
GeneOntologyCellularComponent	anchoring junction	DCHS2 CDH26 CEACAM5 MLC1 TNC AHNAK SYNE2 FYB1 CLDN10 ARHGAP21 RAB13 WNK4 ITK	1.91e-04	976	87	13	GO:0070161
GeneOntologyCellularComponent	leading edge membrane	GABRG2 ANK1 SYNE2 SH3BGRL3 SLC12A5 GABRA4	2.46e-04	210	87	6	GO:0031256
GeneOntologyCellularComponent	neuron projection membrane	GABRG2 ANK1 SLC12A5 GABRA4	3.82e-04	82	87	4	GO:0032589
GeneOntologyCellularComponent	cell projection membrane	GABRG2 RAB35 CEACAM5 ANK1 SYNE2 SH3BGRL3 SLC12A5 GABRA4	4.31e-04	431	87	8	GO:0031253
GeneOntologyCellularComponent	synaptic membrane	GABRG2 ANK1 NRCAM NSG1 NBEA GRIK1 GRM6 SLC12A5 GABRA4	7.12e-04	583	87	9	GO:0097060
GeneOntologyCellularComponent	cell-cell junction	DCHS2 CDH26 CEACAM5 MLC1 AHNAK CLDN10 RAB13 WNK4 ITK	7.85e-04	591	87	9	GO:0005911
GeneOntologyCellularComponent	postsynaptic specialization membrane	GABRG2 NRCAM GRIK1 SLC12A5 GABRA4	1.53e-03	201	87	5	GO:0099634
GeneOntologyCellularComponent	dendrite membrane	GABRG2 SLC12A5 GABRA4	1.65e-03	56	87	3	GO:0032590
GeneOntologyCellularComponent	chloride channel complex	GABRG2 CLCN1 GABRA4	1.73e-03	57	87	3	GO:0034707
Domain	Chemokine_XCL1/XCL2	XCL2 XCL1	2.05e-05	2	85	2	IPR008105
Domain	DUF1088	NBEA LRBA	2.05e-05	2	85	2	IPR010508
Domain	TMEM9	TMEM9 TMEM9B	2.05e-05	2	85	2	IPR008853
Domain	DUF1088	NBEA LRBA	2.05e-05	2	85	2	PF06469
Domain	Tmemb_9	TMEM9 TMEM9B	2.05e-05	2	85	2	PF05434
Domain	NFAT	NFATC1 NFATC2	2.03e-04	5	85	2	IPR008366
Domain	DUF4704	NBEA LRBA	2.03e-04	5	85	2	IPR031570
Domain	DUF4704	NBEA LRBA	2.03e-04	5	85	2	PF15787
Domain	-	COL12A1 CEACAM5 NRCAM NFATC1 PIGR NFATC2 TNC UNC5B CEACAM16 ADAMTSL3 LRIT1	2.04e-04	663	85	11	2.60.40.10
Domain	PH_BEACH	NBEA LRBA	3.03e-04	6	85	2	PF14844
Domain	Ig-like_fold	COL12A1 CEACAM5 NRCAM NFATC1 PIGR NFATC2 TNC UNC5B CEACAM16 ADAMTSL3 LRIT1	3.49e-04	706	85	11	IPR013783
Domain	PH-BEACH_dom	NBEA LRBA	5.63e-04	8	85	2	IPR023362
Domain	-	NBEA LRBA	5.63e-04	8	85	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	5.63e-04	8	85	2	PS51783
Domain	IGc2	CEACAM5 NRCAM UNC5B CEACAM16 ADAMTSL3 LRIT1	7.11e-04	235	85	6	SM00408
Domain	Ig_sub2	CEACAM5 NRCAM UNC5B CEACAM16 ADAMTSL3 LRIT1	7.11e-04	235	85	6	IPR003598
Domain	ZU5	ANK1 UNC5B	7.22e-04	9	85	2	SM00218
Domain	BEACH_dom	NBEA LRBA	7.22e-04	9	85	2	IPR000409
Domain	BEACH	NBEA LRBA	7.22e-04	9	85	2	PS50197
Domain	Beach	NBEA LRBA	7.22e-04	9	85	2	PF02138
Domain	-	NBEA LRBA	7.22e-04	9	85	2	1.10.1540.10
Domain	Beach	NBEA LRBA	7.22e-04	9	85	2	SM01026
Domain	RHD_dimer	NFATC1 NFATC2	9.00e-04	10	85	2	IPR032397
Domain	RHD_dimer	NFATC1 NFATC2	9.00e-04	10	85	2	PF16179
Domain	NFkB/Dor	NFATC1 NFATC2	9.00e-04	10	85	2	IPR000451
Domain	REL_1	NFATC1 NFATC2	9.00e-04	10	85	2	PS01204
Domain	RHD_DNA_bind_dom	NFATC1 NFATC2	9.00e-04	10	85	2	IPR011539
Domain	RHD_DNA_bind	NFATC1 NFATC2	9.00e-04	10	85	2	PF00554
Domain	ZU5	ANK1 UNC5B	9.00e-04	10	85	2	PS51145
Domain	REL_2	NFATC1 NFATC2	9.00e-04	10	85	2	PS50254
Domain	-	NFATC1 NFATC2	9.00e-04	10	85	2	2.60.40.340
Domain	-	COL12A1 NBEA LRBA ADGRG4	9.28e-04	95	85	4	2.60.120.200
Domain	ZU5	ANK1 UNC5B	1.31e-03	12	85	2	PF00791
Domain	ZU5_dom	ANK1 UNC5B	1.31e-03	12	85	2	IPR000906
Domain	Ig_I-set	CEACAM5 NRCAM UNC5B ADAMTSL3 LRIT1	1.76e-03	190	85	5	IPR013098
Domain	ig	CEACAM5 NRCAM PIGR ADAMTSL3 LRIT1	1.76e-03	190	85	5	PF00047
Domain	Immunoglobulin	CEACAM5 NRCAM PIGR ADAMTSL3 LRIT1	1.76e-03	190	85	5	IPR013151
Domain	I-set	CEACAM5 NRCAM UNC5B ADAMTSL3 LRIT1	1.76e-03	190	85	5	PF07679
Domain	EGF_extracell	RELN TNC TENM1	2.58e-03	60	85	3	IPR013111
Domain	EGF_2	RELN TNC TENM1	2.58e-03	60	85	3	PF07974
Domain	IG	CEACAM5 NRCAM PIGR UNC5B CEACAM16 ADAMTSL3 LRIT1	3.07e-03	421	85	7	SM00409
Domain	Ig_sub	CEACAM5 NRCAM PIGR UNC5B CEACAM16 ADAMTSL3 LRIT1	3.07e-03	421	85	7	IPR003599
Domain	EGF	RELN TNC TENM1 MUC13 TECTA	4.38e-03	235	85	5	SM00181
Domain	RAB	RAB35 RAB1B RAB13	4.50e-03	73	85	3	PS51419
Domain	GABAA/Glycine_rcpt	GABRG2 GABRA4	4.87e-03	23	85	2	IPR006028
Domain	EGF-like_dom	RELN TNC TENM1 MUC13 TECTA	5.58e-03	249	85	5	IPR000742
Pathway	REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS	RAB35 RAB1C RAB1B GDI1 RAB13	6.11e-05	91	65	5	MM15518
Pathway	REACTOME_RAB_REGULATION_OF_TRAFFICKING	RAB35 RAB1C RAB1B GDI1 RAB13	2.09e-04	118	65	5	MM15589
Pathway	REACTOME_RAB_GERANYLGERANYLATION	RAB35 RAB1C RAB1B RAB13	2.26e-04	65	65	4	MM15511
Pathway	REACTOME_NEUROFASCIN_INTERACTIONS	ANK1 NRCAM	4.33e-04	7	65	2	M27380
Pathway	REACTOME_NRCAM_INTERACTIONS	ANK1 NRCAM	4.33e-04	7	65	2	M27378
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	GABRG2 SLC12A5 GABRA4	7.03e-04	38	65	3	M39854
Pathway	REACTOME_CALCINEURIN_ACTIVATES_NFAT	NFATC1 NFATC2	7.38e-04	9	65	2	M27106
Pathway	REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS	RAB35 RAB1B GDI1 RAB13	7.81e-04	90	65	4	M27779
Pathway	WP_TCELL_RECEPTOR_SIGNALING	NFATC1 NFATC2 FYB1 ITK	7.81e-04	90	65	4	M39725
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	GABRG2 RELN NRCAM RAPGEF4 NBEA GRIK1 TACR1 GRM6	9.04e-07	300	87	8	19086053
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GABRG2 GRIK1 TACR1 GRM6 GABRA4	1.92e-06	81	87	5	22723691
Pubmed	Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.	GABRG2 SLC12A5 GABRA4	2.46e-06	11	87	3	38894703
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 ANK1 SLC25A13 RAPGEF4 NAV2 NBEA LRBA ARHGAP21 WNK4	4.42e-06	497	87	9	36774506
Pubmed	The biochemical anatomy of cortical inhibitory synapses.	GABRG2 NBEA GABRA4	5.39e-06	14	87	3	22768092
Pubmed	Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.	XCL2 XCL1	6.19e-06	2	87	2	8849694
Pubmed	The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.	NFATC1 NFATC2	6.19e-06	2	87	2	25680272
Pubmed	The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways.	TMEM9 TMEM9B	6.19e-06	2	87	2	18541524
Pubmed	NFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains.	NFATC1 NFATC2	6.19e-06	2	87	2	26483414
Pubmed	Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells.	NFATC1 NFATC2	6.19e-06	2	87	2	17438271
Pubmed	Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells.	RAB1B GDI1	6.19e-06	2	87	2	8836150
Pubmed	Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity.	NFATC1 NFATC2	6.19e-06	2	87	2	25583478
Pubmed	NFAT1 and NFAT2 Differentially Regulate CTL Differentiation Upon Acute Viral Infection.	NFATC1 NFATC2	6.19e-06	2	87	2	30828328
Pubmed	Adenovirus-mediated intratumoral lymphotactin gene transfer potentiates the antibody-targeted superantigen therapy of cancer.	XCL2 XCL1	6.19e-06	2	87	2	12226740
Pubmed	NFATc1 and NFATc2 repress spontaneous osteoarthritis.	NFATC1 NFATC2	6.19e-06	2	87	2	24248346
Pubmed	Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.	NFATC1 NFATC2	6.19e-06	2	87	2	37933452
Pubmed	Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice.	XCL2 XCL1	6.19e-06	2	87	2	24778093
Pubmed	Molecular cloning and functional characterization of human lymphotactin.	XCL2 XCL1	6.19e-06	2	87	2	7602097
Pubmed	Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation.	NFATC1 ITK	6.19e-06	2	87	2	12810687
Pubmed	Association between GABA(A) receptor subunit polymorphisms and autism spectrum disorder (ASD).	GABRG2 GABRA4	6.19e-06	2	87	2	26239769
Pubmed	Cajal-Retzius cells switch from expressing gamma-less to gamma-containing GABA receptors during corticogenesis.	GABRG2 RELN	6.19e-06	2	87	2	17074040
Pubmed	Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp.	NFATC1 NFATC2	6.19e-06	2	87	2	7842733
Pubmed	NF-AT components define a family of transcription factors targeted in T-cell activation.	NFATC1 NFATC2	6.19e-06	2	87	2	8202141
Pubmed	Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity.	XCL2 XCL1	6.19e-06	2	87	2	9834111
Pubmed	Membrane microdomain organization, calcium signal, and NFAT activation as an important axis in polarized Th cell function.	NFATC1 NFATC2	6.19e-06	2	87	2	23184643
Pubmed	Monomeric solution structure of the prototypical 'C' chemokine lymphotactin.	XCL2 XCL1	6.19e-06	2	87	2	11601972
Pubmed	A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth.	RAB1C RAB1B	6.19e-06	2	87	2	33898333
Pubmed	Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex.	NFATC1 NFATC2	6.19e-06	2	87	2	21148038
Pubmed	Molecular cloning of a novel C or gamma type chemokine, SCM-1.	XCL2 XCL1	6.19e-06	2	87	2	7875320
Pubmed	In-vitro activation of cytotoxic T lymphocytes by fusion of mouse hepatocellular carcinoma cells and lymphotactin gene-modified dendritic cells.	XCL2 XCL1	6.19e-06	2	87	2	17990361
Pubmed	T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production.	XCL2 XCL1	6.19e-06	2	87	2	22528127
Pubmed	Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis.	NFATC1 NFATC2	6.19e-06	2	87	2	32329053
Pubmed	Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.	XCL2 XCL1	6.19e-06	2	87	2	25497737
Pubmed	Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.	XCL2 XCL1	6.19e-06	2	87	2	19097989
Pubmed	NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription.	NFATC1 NFATC2	6.19e-06	2	87	2	12355451
Pubmed	Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection.	NFATC1 NFATC2	6.19e-06	2	87	2	26851216
Pubmed	Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia.	XCL2 XCL1	6.19e-06	2	87	2	8757601
Pubmed	Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.	NFATC1 NFATC2	6.19e-06	2	87	2	18809576
Pubmed	Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.	XCL2 XCL1	6.19e-06	2	87	2	9029087
Pubmed	Regulation of the murine Nfatc1 gene by NFATc2.	NFATC1 NFATC2	6.19e-06	2	87	2	11786533
Pubmed	A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells.	XCL2 XCL1	6.19e-06	2	87	2	30542351
Pubmed	Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice.	GABRG2 SLC12A5	6.19e-06	2	87	2	26655909
Pubmed	NFATc1 and NFATc2 together control both T and B cell activation and differentiation.	NFATC1 NFATC2	6.19e-06	2	87	2	11163226
Pubmed	An enhanced immune response in mice lacking the transcription factor NFAT1.	NFATC1 NFATC2	6.19e-06	2	87	2	8629027
Pubmed	Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein.	XCL2 XCL1	6.19e-06	2	87	2	14734774
Pubmed	Reciprocal NFAT1 and NFAT2 nuclear localization in CD8+ anergic T cells is regulated by suboptimal calcium signaling.	NFATC1 NFATC2	6.19e-06	2	87	2	17785810
Pubmed	The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation.	XCL2 XCL1	6.19e-06	2	87	2	31413355
Pubmed	Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.	NFATC1 NFATC2	6.19e-06	2	87	2	9845362
Pubmed	Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin.	XCL2 XCL1	6.19e-06	2	87	2	11181058
Pubmed	Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells).	NFATC1 NFATC2	6.19e-06	2	87	2	20631193
Pubmed	Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.	NFATC2 FYB1 ITK	1.67e-05	20	87	3	31591574
Pubmed	Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.	RAB35 RAB1C RAB1B RAB13	1.71e-05	61	87	4	12578829
Pubmed	Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).	CEACAM16 TECTA	1.85e-05	3	87	2	21368133
Pubmed	Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse.	RELN TNC	1.85e-05	3	87	2	7506500
Pubmed	NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.	NFATC1 NFATC2	1.85e-05	3	87	2	7650004
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	1.85e-05	3	87	2	28814779
Pubmed	Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	18097033
Pubmed	NFAT transcription factors are essential and redundant actors for leukemia initiating potential in T-cell acute lymphoblastic leukemia.	NFATC1 NFATC2	1.85e-05	3	87	2	34234374
Pubmed	Selective activation of NFAT by promyelocytic leukemia protein.	NFATC1 NFATC2	1.85e-05	3	87	2	18246125
Pubmed	Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.	NFATC1 NFATC2	1.85e-05	3	87	2	16275763
Pubmed	A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.	XCL2 XCL1	1.85e-05	3	87	2	28550205
Pubmed	Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation.	XCL2 XCL1	1.85e-05	3	87	2	9199871
Pubmed	Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions.	CEACAM16 TECTA	1.85e-05	3	87	2	25080593
Pubmed	FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.	NFATC1 NFATC2	1.85e-05	3	87	2	19564342
Pubmed	Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.	XCL2 XCL1	1.85e-05	3	87	2	19913446
Pubmed	Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	12594266
Pubmed	A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.	GABRG2 SLC12A5	1.85e-05	3	87	2	24849355
Pubmed	NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells.	NFATC1 NFATC2	1.85e-05	3	87	2	19900447
Pubmed	Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients.	NFATC1 NFATC2	1.85e-05	3	87	2	17082665
Pubmed	Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.	NFATC1 NFATC2	1.85e-05	3	87	2	17082579
Pubmed	Contribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease.	GABRG2 RELN	1.85e-05	3	87	2	27889765
Pubmed	NFATc1 controls the cytotoxicity of CD8+ T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	28894104
Pubmed	Identification of single C motif-1/lymphotactin receptor XCR1.	XCL2 XCL1	1.85e-05	3	87	2	9632725
Pubmed	An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	15057750
Pubmed	Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice.	RELN TACR1	1.85e-05	3	87	2	31122949
Pubmed	The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	11937535
Pubmed	Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.	XCL2 XCL1	1.85e-05	3	87	2	20541533
Pubmed	Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	18078995
Pubmed	Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2.	NFATC1 NFATC2	1.85e-05	3	87	2	15632146
Pubmed	Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9+ T Cells.	NFATC1 NFATC2	1.85e-05	3	87	2	34367143
Pubmed	Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.	NFATC1 NFATC2	1.85e-05	3	87	2	9388475
Pubmed	Transcriptional activation of the IL31 gene by NFAT and STAT6.	NFATC1 NFATC2	1.85e-05	3	87	2	22045870
Pubmed	NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms.	NFATC1 NFATC2	1.85e-05	3	87	2	25630465
Pubmed	NFAT and Osterix cooperatively regulate bone formation.	NFATC1 NFATC2	1.85e-05	3	87	2	16041384
Pubmed	NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	22627363
Pubmed	Lymphotactin acts as an innate mucosal adjuvant.	XCL2 XCL1	1.85e-05	3	87	2	9973465
Pubmed	The transcription factor NFAT4 is involved in the generation and survival of T cells.	NFATC1 NFATC2	1.85e-05	3	87	2	9768749
Pubmed	Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA.	GABRG2 GABRA4	1.85e-05	3	87	2	17124266
Pubmed	Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.	CEACAM16 TECTA	1.85e-05	3	87	2	22544735
Pubmed	Microglial Inhibition Influences XCL1/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy.	XCL2 XCL1	1.85e-05	3	87	2	27387353
Pubmed	Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.	RAB35 RAB1C RAB1B RAB13	3.30e-05	72	87	4	16923123
Pubmed	GABAA/benzodiazepine receptor gamma 2 subunit gene expression in developing normal and mutant mouse cerebellum.	GABRG2 RELN	3.70e-05	4	87	2	8395631
Pubmed	Alternative splicing and expression of human and mouse NFAT genes.	NFATC1 NFATC2	3.70e-05	4	87	2	18675896
Pubmed	Transcription factors of the NFAT family: regulation and function.	NFATC1 NFATC2	3.70e-05	4	87	2	9143705
Pubmed	Sequential involvement of NFAT and Egr transcription factors in FasL regulation.	NFATC1 NFATC2	3.70e-05	4	87	2	10755616
Pubmed	Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity.	NFATC1 NFATC2	3.70e-05	4	87	2	12021260
Pubmed	Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.	NFATC1 NFATC2	3.70e-05	4	87	2	25918731
Pubmed	Comment on "constitutive nuclear localization of NFAT in Foxp3(+) regulatory T cells independent of calcineurin activity".	NFATC1 NFATC2	3.70e-05	4	87	2	23125425
Pubmed	Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT.	NFATC1 NFATC2	3.70e-05	4	87	2	19338776
Pubmed	Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome.	NFATC1 NFATC2	3.70e-05	4	87	2	28172997
Interaction	STX7 interactions	RAB35 BNIP2 TMEM9 UNC5B SYNE2 LMTK2 KIAA1549 RAB11FIP5 NBEA RAB1B LRBA SMCR8 SLC1A5 ARHGAP21	3.93e-07	659	82	14	int:STX7
Interaction	RAB3B interactions	BNIP2 TMEM9 PIGR SYNE2 KIAA1549 RAB11FIP5 SMCR8 GDI1 SLC1A5	4.70e-06	310	82	9	int:RAB3B
Interaction	RAB9A interactions	TAPT1 TMEM9 SYNE2 LMTK2 KIAA1549 RAB11FIP5 NBEA RAB1B LRBA SMCR8 GDI1 SLC1A5	4.94e-06	595	82	12	int:RAB9A
Interaction	RAB35 interactions	RAB35 UNC5B SLC25A13 SYNE2 KIAA1549 RAB11FIP5 SMCR8 GDI1 SLC1A5 ARHGAP21 RAB13	2.01e-05	573	82	11	int:RAB35
Interaction	DENND6A interactions	SPACA1 LMTK2 RAB11FIP5 NBEA LRBA	2.23e-05	83	82	5	int:DENND6A
Interaction	GJA1 interactions	RAB35 UNC5B SYNE2 LMTK2 KIAA1549 RAB11FIP5 NBEA LRBA SMCR8 SLC1A5 ARHGAP21	2.36e-05	583	82	11	int:GJA1
Interaction	RAB11A interactions	BNIP2 SYNE2 RAB1C LMTK2 KIAA1549 RAB11FIP5 NBEA RAB1B LRBA SMCR8 GDI1 SLC1A5 RAB13	2.87e-05	830	82	13	int:RAB11A
Interaction	LAMTOR1 interactions	RAB35 BNIP2 UNC5B SLC25A13 LMTK2 KIAA1549 RAB11FIP5 NBEA RAB1B LRBA SMCR8 SLC1A5	3.39e-05	722	82	12	int:LAMTOR1
Interaction	TMEM17 interactions	TMEM9 UNC5B TENM1 KIAA1549 RAB11FIP5 NBEA LRBA SMCR8 SLC1A5	3.85e-05	404	82	9	int:TMEM17
Interaction	RAB7A interactions	RAB35 TAPT1 SYNE2 TENM1 RAB11FIP5 POMGNT1 NBEA RAB1B MUC13 LRBA SMCR8 GDI1 RAB13	5.63e-05	886	82	13	int:RAB7A
Interaction	STX6 interactions	TMEM9 UNC5B LMTK2 RAB11FIP5 NBEA LRBA TMEM9B SMCR8 ARHGAP21	8.53e-05	448	82	9	int:STX6
Interaction	ZFPL1 interactions	UNC5B LMTK2 KIAA1549 RAB11FIP5 NBEA LRBA SMCR8 SLC1A5 ARHGAP21	8.53e-05	448	82	9	int:ZFPL1
Interaction	CLEC4E interactions	TAPT1 TMEM9 SLC25A13 SYNE2 POMGNT1 RAB1B SMCR8 SH3BGRL3	9.45e-05	353	82	8	int:CLEC4E
Interaction	RAB1C interactions	RAB1C LMTK2 RAB1B	9.46e-05	22	82	3	int:RAB1C
Interaction	RAB4A interactions	SYNE2 LMTK2 KIAA1549 RAB11FIP5 NBEA LRBA SMCR8 GDI1 SLC1A5	9.92e-05	457	82	9	int:RAB4A
Interaction	CLDN1 interactions	RAB35 TMEM9 WNK4	1.58e-04	26	82	3	int:CLDN1
Interaction	XCR1 interactions	XCL2 XCL1	1.62e-04	5	82	2	int:XCR1
Interaction	CAV1 interactions	RAB35 MLC1 UNC5B LMTK2 KIAA1549 RAB11FIP5 TACR1 LRBA SMCR8 SLC1A5 ARHGAP21	1.64e-04	724	82	11	int:CAV1
Cytoband	18q23	NFATC1 ATP9B	1.39e-03	29	87	2	18q23
Cytoband	4q31.3	DCHS2 LRBA	1.59e-03	31	87	2	4q31.3
Cytoband	10p12.1	PTCHD3 ARHGAP21	1.70e-03	32	87	2	10p12.1
Cytoband	7q21.3	SLC25A13 LMTK2	2.51e-03	39	87	2	7q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr18q23	NFATC1 ATP9B	2.64e-03	40	87	2	chr18q23
GeneFamily	RAB, member RAS oncogene GTPases	RAB35 RAB1C RAB1B RAB13	8.74e-05	65	65	4	388
GeneFamily	Nuclear factors of activated T-cells	NFATC1 NFATC2	1.26e-04	5	65	2	665
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CEACAM5 NRCAM UNC5B ADAMTSL3 LRIT1	2.82e-04	161	65	5	593
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	4.51e-04	9	65	2	1230
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRG2 GABRA4	2.09e-03	19	65	2	563
GeneFamily	Fibronectin type III domain containing	COL12A1 NRCAM TNC LRIT1	2.63e-03	160	65	4	555
GeneFamily	CD molecules\|V-set domain containing\|Immunoglobulin like domain containing\|Carcinoembryonic antigen related cell adhesion molecule family	CEACAM5 CEACAM16	3.34e-03	24	65	2	906
GeneFamily	Immunoglobulin like domain containing	CEACAM5 NRCAM CEACAM16 ADAMTSL3	5.13e-03	193	65	4	594
Coexpression	GSE24972_WT_VS_IRF8_KO_MARGINAL_ZONE_SPLEEN_BCELL_DN	RNF150 TAF3 PIGR MLC1 RAPGEF4 ARHGAP21 LRIT1	4.23e-06	199	86	7	M8094
Coexpression	YOSHIMURA_MAPK8_TARGETS_UP	GABRG2 CLCN1 NRCAM PIGR TNC KCNJ5 NSG1 RAPGEF4 GEMIN4 GRIK1 TACR1 RAB1B MUC13 SLC12A5 FABP6	1.66e-05	1281	86	15	M1884
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMEM132C NFATC2 SYNE2 NSG1 XCL2 ADGRG4 SH3BGRL3	1.01e-07	192	87	7	ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMEM132C NFATC2 SYNE2 NSG1 XCL2 ADGRG4 SH3BGRL3	1.01e-07	192	87	7	58a7829b411b02b422ef75e2277a868969cc23e8
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE2 NSG1 XCL2 FYB1 XCL1 SH3BGRL3 ITK	1.09e-07	194	87	7	68e9ad254fe94e2f59cf5c2b2ea3e1245cb85104
ToppCell	Control-Control-Lymphocyte-T/NK-CD8+_Tem\|Control / Disease, condition lineage and cell class	ZBTB38 NFATC2 SYNE2 NSG1 XCL2 RAB11FIP5 ITK	1.34e-07	200	87	7	fddb3df5b90eb97ef8ed80fac320c1a90903f012
ToppCell	BAL-Severe-cDC_2\|Severe / Compartment, Disease Groups and Clusters	SYNE2 NSG1 XCL2 RAB11FIP5 XCL1 ITK	9.09e-07	166	87	6	602a72a607534d5f21eddd2c7a52a57084f4920f
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	DCHS2 CDH26 PIGR NBEA TACR1 STRA6	1.20e-06	174	87	6	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM132C COL12A1 ANK1 UNC5B CEACAM16 TENM1	1.36e-06	178	87	6	c982a73955c9c193bcab21d60d453afcc09cd586
ToppCell	Adult-Epithelial-lung_goblet_cell\|Adult / Lineage, Cell type, age group and donor	DCHS2 CDH26 PIGR NBEA TACR1 STRA6	1.41e-06	179	87	6	1fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM141 CEACAM5 CLCN1 PIGR MUC13 ADGRG4	1.46e-06	180	87	6	7c7c4d64ff99d0710a7d19d8bc29fc9217394db1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM132C COL12A1 ANK1 UNC5B CEACAM16 TENM1	1.50e-06	181	87	6	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFATC2 MLC1 XCL2 FYB1 XCL1 ITK	1.71e-06	185	87	6	45890fa81c65a48f4fdec164a4c8d0e2831243c0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFATC2 MLC1 XCL2 FYB1 XCL1 ITK	1.71e-06	185	87	6	585bcfdff85bf43f5aa4cd1b39f7dcf1c78d7b02
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 SYNE2 XCL2 TENM1 LRBA ITK	1.76e-06	186	87	6	bbcd9062c0f6f65ca6f3cb101b6fa72ddd1e14fe
ToppCell	Tuft\|World / Class top	ANK1 NRCAM NFATC1 TNC NAV2 FYB1	1.76e-06	186	87	6	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	11.5-Airway-Immune-Hematopoietic,_Natural_Killer_Cell\|Airway / Age, Tissue, Lineage and Cell class	MLC1 XCL2 SMCR8 FYB1 XCL1 ITK	1.82e-06	187	87	6	bebb56d31a1df678d85a29931a2ec585549ac122
ToppCell	Tuft-tuft-2\|World / Class top	ANK1 NRCAM NFATC1 TNC NAV2 FYB1	1.82e-06	187	87	6	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	Fetal_29-31_weeks-Immune-natural_killer_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NFATC2 MLC1 XCL2 FYB1 XCL1 ITK	1.93e-06	189	87	6	c604da558c9f4055fb36218452463539f2a73223
ToppCell	tumor_Lung-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	SYNE2 XCL2 FYB1 XCL1 SH3BGRL3 ITK	1.99e-06	190	87	6	e3ba8d36e0ad9525912b1891922573b55a1d5ed9
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 PIGR NBEA MUC13 STRA6 CLDN10	1.99e-06	190	87	6	23f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCell	10x5'-blood-Lymphocytic_T_CD8-Trm/em_CD8\|blood / Manually curated celltypes from each tissue	ZBTB38 GBP4 NFATC2 SYNE2 NSG1 XCL2	1.99e-06	190	87	6	e1f474dc36bf9eaf457b14a8761d287904754cdc
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 PIGR NBEA MUC13 STRA6 CLDN10	1.99e-06	190	87	6	3c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell	Control-Lymphoid-NK\|Control / Disease state, Lineage and Cell class	NFATC2 MLC1 SYNE2 XCL2 XCL1 ITK	1.99e-06	190	87	6	f7bd8521a40ac30a64dc439f17e2f6c7d021ef65
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 SYNE2 NSG1 XCL2 RAB11FIP5 SH3BGRL3	2.05e-06	191	87	6	b2d0ea24970da09209da9d9dda76e30fbfe22917
ToppCell	Adult-Immune-natural_killer_cell\|Adult / Lineage, Cell type, age group and donor	NFATC2 MLC1 SYNE2 XCL2 FYB1 ITK	2.05e-06	191	87	6	758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NFATC2 MLC1 XCL2 TENM1 FYB1 ITK	2.05e-06	191	87	6	6345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD8_TEM\|Leuk-UTI / Disease, Lineage and Cell Type	ZBTB38 NFATC2 SYNE2 XCL2 XCL1 ITK	2.12e-06	192	87	6	2787b52546eedada4aa413025b86841c351273f4
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 NFATC2 SYNE2 XCL2 RAB11FIP5 SH3BGRL3	2.12e-06	192	87	6	01d01c9293f2439dc4c34c648273319c9beee5c7
ToppCell	Immune-natural_killer_cell\|World / Lineage, Cell type, age group and donor	NFATC2 MLC1 XCL2 FYB1 XCL1 ITK	2.12e-06	192	87	6	68121a6ef4115a93d87aad8802ef9b27d793d8c0
ToppCell	normal_Pleural_Fluid-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	AHNAK SYNE2 NSG1 XCL2 FYB1 ITK	2.12e-06	192	87	6	c13a438c46ee240e5832ec76880207451155c8df
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB38 NFATC2 SYNE2 XCL2 RAB11FIP5 SH3BGRL3	2.12e-06	192	87	6	0f8c63de26128694f4522f9f6d029e4628c890bc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.18e-06	193	87	6	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.18e-06	193	87	6	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 NAV2 GRIK1 ADAMTSL3	2.18e-06	193	87	6	2c15186d15545804cc262da9137ab825609d4b2c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.18e-06	193	87	6	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	CD8+_Memory_T_cell-CV-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ZBTB38 AHNAK SYNE2 XCL2 XCL1 SH3BGRL3	2.18e-06	193	87	6	995781d87a919c0380750878bafe584342bb83ad
ToppCell	CV-Mild-0\|CV / Virus stimulation, Condition and Cluster	AHNAK SYNE2 XCL2 FYB1 XCL1 SH3BGRL3	2.18e-06	193	87	6	90417c7da2fa9d4dc9634bfb5ec3a6e789ef2048
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHNAK SYNE2 XCL2 FYB1 XCL1 ITK	2.18e-06	193	87	6	8c3771a6b81cf48a46a14c5c869ffc96fd996fb7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHNAK SYNE2 XCL2 FYB1 XCL1 ITK	2.18e-06	193	87	6	ec5ae47719e0d6c989f8818d029ad5c3913eb85d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.18e-06	193	87	6	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.18e-06	193	87	6	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.18e-06	193	87	6	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB38 SYNE2 NSG1 XCL2 RAB11FIP5 ITK	2.25e-06	194	87	6	e72be6dc2711c1d4f16943c8615cf9dc2e961ff3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.25e-06	194	87	6	83863da11dfbe59b2d0a2c08db40b537c150588c
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZBTB38 SYNE2 NSG1 XCL2 RAB11FIP5 ITK	2.25e-06	194	87	6	ac03be73fdc32dacd4a450c0fb28617e043b8444
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZBTB38 SYNE2 NSG1 XCL2 RAB11FIP5 ITK	2.25e-06	194	87	6	7ab4418a8a12c488d74af3676bdac672628da80c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.25e-06	194	87	6	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB38 SYNE2 NSG1 XCL2 RAB11FIP5 ITK	2.25e-06	194	87	6	760761ce7d22edf9a8cec71e8ab0caa273fce3f7
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NFATC2 SYNE2 XCL2 FYB1 XCL1 ITK	2.31e-06	195	87	6	ffb40486f8097b2c08e8f3b3685d0b8cb8d1bc66
ToppCell	nucseq-Immune-Lymphocytic_T/NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NFATC2 SYNE2 XCL2 FYB1 XCL1 ITK	2.31e-06	195	87	6	b8124e8a23e6d37b40023608674e67285c6ffe84
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB38 NFATC2 MLC1 SYNE2 XCL2 RAB11FIP5	2.31e-06	195	87	6	0b50b5c71a4949f3f8fb9f5c30f9d50f53ca050d
ToppCell	critical-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	AHNAK SYNE2 XCL2 FYB1 XCL1 ITK	2.38e-06	196	87	6	c861f017aa9050282aa81c5a445bae399df00e4f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 ANK1 PIGR MUC13 STRA6 CLDN10	2.38e-06	196	87	6	2c3fbfbb08cd327cd97b3fa5a6f83b6d50771fb7
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 ITK	2.38e-06	196	87	6	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 MLC1 AHNAK SYNE2 XCL2 XCL1	2.46e-06	197	87	6	f84263c5aaf3a5cd46d6e06358e8de6c6e6eaa3b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 XCL2	2.46e-06	197	87	6	2b3a56bb1d40bc1284a5931c4e7b373660de5402
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_Tem\|COVID-19_Severe / Disease group, lineage and cell class	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 XCL2	2.46e-06	197	87	6	f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 XCL2	2.46e-06	197	87	6	f73ece3aca28c0db5db0f12e026d42c6c36b9efb
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 XCL2	2.46e-06	197	87	6	e70e7d97823a762def3970d94a0e897981a6c922
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Teffector/EM_CD4\|lymph-node_spleen / Manually curated celltypes from each tissue	AHNAK SYNE2 NSG1 FYB1 SH3BGRL3 ITK	2.46e-06	197	87	6	c4603bfe9ab537ca64172f65203a5d23671f7354
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHNAK SYNE2 XCL2 FYB1 XCL1 ITK	2.46e-06	197	87	6	80ffafa9473f4ee7a3a792d11b5541e1c984c9f0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MLC1 SYNE2 XCL2 TENM1 FYB1 ITK	2.46e-06	197	87	6	32b770e403028862f91e4727f4a8fbb6151910e4
ToppCell	368C-Lymphocytic-CD4_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SYNE2 XCL2 FYB1 XCL1 SH3BGRL3 ITK	2.46e-06	197	87	6	11762042f9ee8d02af432ccffe1c05aee9cb11ea
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 XCL2	2.46e-06	197	87	6	bce0135a96910d2bace62a3408a1a6fdac0cf0df
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHNAK SYNE2 XCL2 FYB1 XCL1 ITK	2.46e-06	197	87	6	f3dfc22ff63e6173451a0917c5aedcde793fd170
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 NRCAM RAPGEF4 NBEA SLC12A5 GABRA4	2.53e-06	198	87	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD8-positive,_alpha-beta_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZBTB38 SYNE2 XCL2 FYB1 XCL1 SH3BGRL3	2.53e-06	198	87	6	41ead3d3733b79e3e45648d5ce1909e617c35ed7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB38 NFATC2 AHNAK SYNE2 RAB11FIP5 SH3BGRL3	2.53e-06	198	87	6	a6b942fe850e287e1cb705684e29218072daf891
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 NRCAM RAPGEF4 NBEA SLC12A5 GABRA4	2.53e-06	198	87	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DCHS2 CDH26 PIGR NBEA TACR1 CLDN10	2.53e-06	198	87	6	fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CEACAM5 PIGR NAV2 NBEA MUC13 CLDN10	2.60e-06	199	87	6	7223f853335492ca617dbec3e4b6872a8a463a45
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.68e-06	200	87	6	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 NAV2 GRIK1 ADAMTSL3	2.68e-06	200	87	6	858421b91f5207b7934b5c219752cb9322a3da31
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_Tem\|COVID-19_Severe / Disease, condition lineage and cell class	ZBTB38 NFATC2 AHNAK SYNE2 NSG1 XCL2	2.68e-06	200	87	6	31859b8db7ea17e48b7b54e92f0d76aeb755e7ca
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NFATC2 MLC1 SYNE2 XCL2 XCL1 ITK	2.68e-06	200	87	6	0b65855617fb7730de48facf411e2a8980f9f780
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.68e-06	200	87	6	6a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.68e-06	200	87	6	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 NAV2 GRIK1 ADAMTSL3	2.68e-06	200	87	6	a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-NK-ILC\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NFATC2 MLC1 SYNE2 XCL2 XCL1 ITK	2.68e-06	200	87	6	4150170a135c37a7932bfb61acedac22dad01a3e
ToppCell	severe-NK_CD56bright\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GBP4 MLC1 XCL2 KIAA1549 XCL1 SLC1A5	2.68e-06	200	87	6	82818ab1796fdd0b8be02b341818897595eed841
ToppCell	severe-NK_CD56bright\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GBP4 MLC1 XCL2 KIAA1549 XCL1 SLC1A5	2.68e-06	200	87	6	2e67068b98696c313b815a2f0c98643f892e8bc0
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NFATC2 MLC1 SYNE2 XCL2 XCL1 ITK	2.68e-06	200	87	6	b4d956067eb292cf2855c674d1eb05a5f2d988f7
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 NAV2 GRIK1	2.68e-06	200	87	6	347a510755374c6a66acee326565dfc447993f18
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.68e-06	200	87	6	8d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.68e-06	200	87	6	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 TENM1 GRIK1 ADAMTSL3	2.68e-06	200	87	6	cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-CD8+_Tem\|Leuk-UTI / Disease, condition lineage and cell class	ZBTB38 NFATC2 SYNE2 XCL2 XCL1 ITK	2.68e-06	200	87	6	aa8104dcb2ba5756a23c25a580bef2360ff25b13
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NFATC2 MLC1 SYNE2 XCL2 XCL1 ITK	2.68e-06	200	87	6	c09bb5c994f098d86e873bd3f1d911b02563e6e2
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ANK1 KCNJ5 NAV2 GRIK1 ADAMTSL3	2.68e-06	200	87	6	2131c8e7fa054b79906eaf60536da892438b09cd
ToppCell	severe_COVID-19-NK_CD56bright\|World / disease group, cell group and cell class (v2)	MYLK3 XCL2 XCL1 WNK4 SLC12A5	1.22e-05	152	87	5	ab5a4e47b23d16018642d4c9c7f41b30205edf73
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RNF150 COL12A1 NFATC2 TNC NAV2	1.34e-05	155	87	5	82e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RNF150 COL12A1 NFATC2 TNC NAV2	1.34e-05	155	87	5	979c1d53b435a82c57d16707eed8ba7346326866
ToppCell	severe_COVID-19-NK_CD56bright\|severe_COVID-19 / disease group, cell group and cell class (v2)	MYLK3 XCL2 XCL1 WNK4 SLC12A5	1.47e-05	158	87	5	c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	DCHS2 COL12A1 NRCAM KCNJ5 STRA6	1.51e-05	159	87	5	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 XCL2 TENM1 LRBA GABRA4	1.56e-05	160	87	5	8e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCell	Adult-Immune-mast_cell\|Adult / Lineage, Cell type, age group and donor	NRCAM TENM1 KIAA1549 MUC13 XCL1	1.61e-05	161	87	5	44f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCell	URO-Lymphocyte-T_NK-CD4_CTL\|URO / Disease, Lineage and Cell Type	NFATC2 SYNE2 NSG1 RAB11FIP5 ITK	1.66e-05	162	87	5	1afeeb17e263cf625a4f285203cf82f973735193
ToppCell	severe_COVID-19-gd_T\|severe_COVID-19 / disease group, cell group and cell class (v2)	SYNE2 NSG1 XCL2 TECTA XCL1	1.81e-05	165	87	5	49f31173da71c1841616d69b7062852ad7a5090f
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV5/7_gdT\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	XCL2 FYB1 XCL1 SH3BGRL3 ITK	1.92e-05	167	87	5	18e336faa2d2429ab49d1c6ae9bbf9923d74aa8d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NFATC2 AHNAK SYNE2 FYB1 ITK	2.15e-05	171	87	5	e6dfbd2652b67577c8834c05348f62150637f348
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NFATC2 AHNAK SYNE2 FYB1 ITK	2.15e-05	171	87	5	ddaeb96ce9c9c3bf232b4a42266fa2ee7e8f3f41
Drug	NBQX	GABRG2 GRIK1 TACR1 GRM6 SLC12A5 GABRA4	1.26e-06	90	87	6	CID003272523
Drug	6 mEq	GABRG2 GRIK1 SLC12A5 GABRA4	1.38e-06	22	87	4	CID000126186
Drug	N-methyl-DL-aspartic acid	GABRG2 RELN MYLK3 NSG1 GRIK1 TACR1 LRBA TECTA PKD1L3 GRM6 SLC12A5 GABRA4	7.19e-06	655	87	12	CID000004376
Drug	baclofen	GABRG2 KCNJ5 GRIK1 TACR1 PKD1L3 GRM6 GABRA4	8.69e-06	191	87	7	CID000002284
Drug	acamprosate	GABRG2 CEACAM5 GRIK1 GRM6 GABRA4	9.49e-06	74	87	5	CID000071158
Drug	AP-5	GABRG2 GRIK1 TACR1 TECTA GRM6 GABRA4	9.76e-06	128	87	6	CID000001216
Drug	gamma-aminobutyric acid	GABRG2 RELN CLCN1 GRIK1 TACR1 PKD1L3 GRM6 SLC1A5 SLC12A5 GABRA4	1.33e-05	474	87	10	CID000000119
Drug	GTP[S]	MLC1 KCNJ5 RAPGEF4 RAB1C NBEA GRIK1 TACR1 RAB1B LRBA PKD1L3 GRM6	1.54e-05	591	87	11	CID000001764
Drug	DNQX	GABRG2 GRIK1 GRM6 SLC12A5 GABRA4	1.67e-05	83	87	5	CID003899541
Drug	CGP55845	GABRG2 GRIK1 GRM6 GABRA4	1.81e-05	41	87	4	CID000123885
Drug	DE gel	GABRG2 GRIK1 TACR1 GRM6 SLC12A5 GABRA4	1.84e-05	143	87	6	CID000008146
Drug	nimodipine	GABRG2 RAPGEF4 GRIK1 PKD1L3 GRM6 GABRA4	1.99e-05	145	87	6	CID000004497
Drug	Chlorides	GABRG2 CLCN1 SLC12A5 GABRA4	1.99e-05	42	87	4	ctd:D002712
Drug	IPSP	GABRG2 GRIK1 GRM6 SLC12A5 GABRA4	2.09e-05	87	87	5	CID000022083
Drug	isoguvacine	GABRG2 GRIK1 TACR1 GABRA4	2.63e-05	45	87	4	CID000003765
Drug	oriens	GABRG2 RELN GRIK1 TECTA GRM6 GABRA4	2.79e-05	154	87	6	CID000161645
Drug	Ro 31-8220	GABRG2 MLC1 RAPGEF4 GRIK1 TACR1 LRBA GRM6 GABRA4	3.18e-05	321	87	8	CID000005083
Drug	5,7-dichlorokynurenic acid	GRIK1 TACR1 GRM6 SLC1A5	3.70e-05	49	87	4	CID000001779
Drug	biotinyl-L-lysine	GABRG2 GRIK1 TACR1 TECTA GABRA4	3.91e-05	99	87	5	CID000083814
Drug	gabapentin	GABRG2 GRIK1 PKD1L3 GRM6 SLC1A5 GABRA4	4.70e-05	169	87	6	CID000003446
Drug	urethane	GABRG2 PTCHD3 TNC GRIK1 TACR1 GABRA4	4.70e-05	169	87	6	CID000005641
Drug	methanethiosulfonate	GABRG2 KCNJ5 GRIK1 SLC1A5 GABRA4	4.73e-05	103	87	5	CID004188587
Drug	picrotoxin	GABRG2 CLCN1 GRIK1 GRM6 SLC12A5 GABRA4	6.88e-05	181	87	6	CID000031304
Drug	prochloraz	RELN TAF3 NRCAM UNC5B GRIK1 SLC1A5 GABRA4	7.58e-05	268	87	7	ctd:C045362
Drug	imidazenil	GABRG2 RELN GABRA4	7.87e-05	22	87	3	CID000119194
Drug	diazepam	GABRG2 CDH26 CEACAM5 GRIK1 SLC12A5 GABRA4	8.74e-05	189	87	6	CID000003016
Drug	CGP 35348	GABRG2 PTCHD3 GRIK1 GABRA4	9.37e-05	62	87	4	CID000107699
Drug	AP-7	GABRG2 GRIK1 GRM6 GABRA4	9.97e-05	63	87	4	CID000003122
Drug	Procyclidine hydrochloride [1508-76-5]; Up 200; 12.4uM; HL60; HT_HG-U133A	PIGR NSG1 RAB11FIP5 ATP9B TACR1 FYB1	1.10e-04	197	87	6	2991_UP
Drug	valdecoxib; Up 200; 10uM; PC3; HT_HG-U133A	CLCN1 NRCAM KCNJ5 NSG1 SLC12A5 FABP6	1.10e-04	197	87	6	6378_UP
Drug	Omeprazole [73590-58-6]; Up 200; 11.6uM; HL60; HT_HG-U133A	ZBTB38 CLCN1 NRCAM NFATC1 KCNJ5 TACR1	1.13e-04	198	87	6	2467_UP
Drug	ICI 182,780; Up 200; 0.01uM; PC3; HT_HG-U133A	ANK1 PIGR RAPGEF4 TENM1 LMTK2 TACR1	1.13e-04	198	87	6	4462_UP
Drug	Bromopride [4093-35-0]; Up 200; 11.6uM; HL60; HT_HG-U133A	TAPT1 NFATC1 AHNAK NAV2 FYB1 SLC12A5	1.13e-04	198	87	6	2182_UP
Drug	C75; Up 200; 10uM; MCF7; HT_HG-U133A	ANK1 PIGR UNC5B KCNJ5 TENM1 TECTA	1.16e-04	199	87	6	6394_UP
Drug	NO-711	GABRG2 GRIK1 GRM6 GABRA4	1.20e-04	66	87	4	CID000004515
Drug	CNQX	GABRG2 GRIK1 TACR1 GRM6 GABRA4	1.23e-04	126	87	5	CID000002821
Drug	V-X-A	GABRG2 GRIK1 GABRA4	1.31e-04	26	87	3	CID006369389
Drug	Linuron	RELN NRCAM UNC5B GRIK1 GABRA4	1.33e-04	128	87	5	ctd:D008044
Drug	Ltnam	XCL2 XCL1	1.43e-04	5	87	2	CID000187080
Drug	Lorazepam	GABRG2 GABRA4	1.43e-04	5	87	2	ctd:D008140
Drug	phaclofen	GABRG2 TNC GRIK1 GABRA4	1.50e-04	70	87	4	CID000001641
Drug	felbamate	GABRG2 GRIK1 GRM6 GABRA4	1.50e-04	70	87	4	CID000003331
Drug	Diazepam	GABRG2 TNC SLC12A5 GABRA4	1.87e-04	74	87	4	ctd:D003975
Drug	AC1L9M5J	RELN NSG1 GEMIN4 GRIK1 TACR1 SLC12A5	2.05e-04	221	87	6	CID000448615
Drug	zaleplon	GABRG2 GABRA4	2.14e-04	6	87	2	ctd:C085665
Disease	1-stearoylglycerol 1-monostearin measurement	SYNE2 KIAA1549	8.20e-06	2	85	2	EFO_0021111
Disease	lymphotactin measurement	XCL2 XCL1	4.90e-05	4	85	2	EFO_0008214
Disease	childhood absence epilepsy (is_implicated_in)	GABRG2 GRIK1	2.27e-04	8	85	2	DOID:1825 (is_implicated_in)
Disease	autistic disorder (is_implicated_in)	RELN RAPGEF4 GABRA4	2.44e-04	42	85	3	DOID:12849 (is_implicated_in)
Disease	Febrile Convulsions	GABRG2 SLC12A5	2.91e-04	9	85	2	C0009952
Disease	survival time	XCL2 XCL1	2.91e-04	9	85	2	EFO_0000714
Disease	pulmonary hypertension (implicated_via_orthology)	NFATC2 TNC TACR1	5.15e-04	54	85	3	DOID:6432 (implicated_via_orthology)
Disease	autistic disorder (is_marker_for)	RELN GABRA4	5.31e-04	12	85	2	DOID:12849 (is_marker_for)
Disease	Autistic Disorder	RELN NRCAM RAB11FIP5 NBEA GABRA4	9.61e-04	261	85	5	C0004352
Disease	Malignant neoplasm of breast	CLCN1 ANK1 NRCAM UNC45B SYNE2 TENM1 LRBA TECTA GRM6 GABRA4	1.03e-03	1074	85	10	C0006142
Disease	cancer	RAB35 ZBTB38 MLC1 RAB1C LMTK2 OR6C6	1.06e-03	400	85	6	MONDO_0004992
Disease	epilepsy (implicated_via_orthology)	GABRG2 NRCAM SLC1A5 SLC12A5	1.28e-03	163	85	4	DOID:1826 (implicated_via_orthology)
Disease	unipolar depression, response to bupropion, mood disorder	TNC FYB1	1.36e-03	19	85	2	EFO_0003761, EFO_0004247, EFO_0006326
Disease	seborrheic dermatitis	UNC5B TACR1	1.51e-03	20	85	2	EFO_1000764
Disease	Nonsyndromic Deafness	TNC CEACAM16 TECTA	1.67e-03	81	85	3	C3711374
Disease	Hepatitis	NAV2 XCL1	1.82e-03	22	85	2	HP_0012115
Disease	Hodgkin Disease	RELN ITK	1.82e-03	22	85	2	C0019829
Disease	peripheral arterial disease, traffic air pollution measurement	TAF3 NAV2 NBEA LRBA	2.42e-03	194	85	4	EFO_0004265, EFO_0007908
Disease	abdominal fat cell number	RNF150 RAB35 RAB1C SLC9C2	2.61e-03	198	85	4	EFO_0021534

Protein segments in the cluster

Peptide	Gene	Start	Entry
TTYEERNITGTRVKV	SLC1A5	206	Q15758
VTKALTTYVVSASIS	ADGRG4	2641	Q8IZF6
RLGYISVTDVLKVVT	ANK1	776	P16157
TDTGRYTLKTVTVQG	CEACAM16	396	Q2WEN9
TGLNRTTVTTITVYA	CEACAM5	306	P06731
KTVTVVYEDSTGLIR	GRIK1	171	P39086
ITVTRRVTAYTVDVT	AHNAK	151	Q09666
KVSTIDGTVITTATY	CLDN10	31	P78369
KEGITVLTTIDSYIV	CFAP251	501	Q8TBY9
VLTTIDSYIVTGDIK	CFAP251	506	Q8TBY9
TYISTIGIDFKIRTV	RAB13	36	P51153
SYISTIGVDFKIRTI	RAB1B	36	Q9H0U4
SYISTIGVDFKIQTI	RAB1C	36	Q92928
SYITTIGVDFKIRTV	RAB35	36	Q15286
TVIQVGREKYSTSVV	RAB11FIP5	46	Q9BXF6
TKVVYEVRSGGTVVE	PALM2	176	Q8IXS6
TETTIGYGFRVITEK	KCNJ5	146	P48544
SIFVATYVSVTSKEV	KIAA1549	136	Q9HCM3
VTDSGRTVILYKVSD	NOL11	36	Q9H8H0
VHRITGKTVTTTSYE	NFATC2	476	Q13469
TSVVVANVSKYIVSG	NRCAM	796	Q92823
VIGVVIYTGKETRSV	ATP9B	346	O43861
YEGEKVSVTTRLLIS	LACTB	201	P83111
TVVGYVLIVVTITAS	OR4C46	36	A6NHA9
YVTILTSKVIGKIVT	OR52B6	151	Q8NGF0
VVSVKETSISAGYEV	MYLK3	501	Q32MK0
RVLYSTKVTTSITSK	FYB1	706	O15117
FYQVHRITGKTVSTT	NFATC1	491	O95644
VVVKGTLSVTSSELY	LRBA	2091	P50851
IYTGTSVARVIVKEL	LMTK2	156	Q8IWU2
VSITEGVTERFKVSV	NSG1	71	P42857
IVTGKRLGTLVVTYV	GBP4	301	Q96PP9
VSSETIKSITGEYIV	GABRA4	231	P48169
VTYTLTATGNITIIS	OR6M1	31	Q8NGM8
VRSVKVVGDTYHSVS	LRIT1	431	Q9P2V4
FIEKASTRYVVSTDV	RELN	2356	P78509
GSRSTTVIIKVYVTD	DCHS2	2016	Q6V1P9
YTVIIVISITRSTGM	OR56B2P	261	Q8NGI1
EKIYIQTTTLTVSLS	GRM6	811	O15303
TVVLEELRAGTTYKV	COL12A1	1141	Q99715
EVSTIGGVTYERVSK	FABP6	111	P51161
RNTTEVVKTTSGDYV	GABRG2	246	P18507
IAETSITITGIKYVV	DHX33	356	Q9H6R0
TTEVIRKGSITEYTA	BNIP2	106	Q12982
TVYFDVVERSTGKIV	CDH26	131	Q8IXH8
QGKYIAIASTTVETT	GDI1	346	P31150
IVATIKFTVYTSSEL	SPACA1	191	Q9HBV2
NVYSKAAVSITITTI	PTCHD3	481	Q3KNS1
TGTILAIATTSAVYI	SLC12A5	456	Q9H2X9
GTYTVSVFTKAVVSE	ITK	271	Q08881
YSVTKGRIITVVYTV	OR1Q1	266	Q15612
QKYVSRTSVVFVSIS	RNF150	201	Q9ULK6
TVLTGTKDTIYSGVT	PLIN4	611	Q96Q06
KAPVRSVVTETVSTY	TAF3	841	Q5VWG9
YTTIRVPVATSVKEV	RAPGEF4	681	Q8WZA2
VKQGEVVTAYVTISS	TMEM132C	301	Q8N3T6
YKEAVTRAVESITSL	SYNE2	3261	Q8WXH0
SRSKVYVAVDGTTVL	POMGNT1	106	Q8WZA1
GTATIYTTIRRVGTV	NBEA	626	Q8NFP9
VAKGTLSITTTEIYF	NBEA	2166	Q8NFP9
GSVYKVSRLETTIST	TACR1	346	P25103
YLVGENTTISVTVKG	NAV2	2106	Q8IVL1
TGYRRSAATTAKVVI	PKD1L3	751	Q7Z443
TQVTLTYEESSGVIK	TENM1	1986	Q9UKZ4
VYSTSVTGSREIKSQ	SH3BGRL3	6	Q9H299
VTVSKGVALLYTSIA	OR6C6	266	A6NF89
TIQKVRAGVTTDVSY	STRA6	321	Q9BX79
VLISVGSYKSSVESV	SMCR8	411	Q8TEV9
IYSTLAGTRKDVEVT	SLC25A13	236	Q9UJS0
TYGELRTLLQTTTVK	CLCN1	621	P35523
TVESKGVVTVQYSDI	TECTA	816	O75443
KTYTITEGSLRAVIF	XCL1	46	P47992
KTYTITEGSLRAVIF	XCL2	46	Q9UBD3
TSDKTILYSVATTLV	UNC45B	566	Q8IWX7
EERSTTTIKVIIVIY	TMEM9	81	Q9P0T7
RSSVTIKVTIIIYLS	TMEM9B	96	Q9NQ34
SVYGQTVILTVSTSL	MUC13	256	Q9H3R2
IVKEYEVRSSGRVVS	TSPYL1	336	Q9H0U9
ISYTGEKVPEITRTV	TNC	1831	P24821
DTKVYTVDLGRTVTI	PIGR	136	P01833
VAKRRSTTATVIVYV	UNC5B	231	Q8IZJ1
GSVVSYGVTRVESEK	TMEM141	71	Q96I45
AYRVKTVTSSGVQVS	ZMYM6	306	O95789
FVIIVYGSVIDTKTE	SLC9C2	1046	Q5TAH2
VVTSSIKVQGILSYA	TAPT1	416	Q6NXT6
IYSSTVVVKRQETVT	ZBTB38	91	Q8NAP3
VRYGVSEQTSLKTVS	ARHGAP21	301	Q5T5U3
KTVYRGLDTDTTVEV	WNK4	186	Q96J92
SRIGNTVYITKRTEV	ADAMTSL3	1196	P82987
SATVYLDKLATVISV	GEMIN4	261	P57678
KSYSVVEVIAGISAV	MLC1	196	Q15049