Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear replisome	POLA1 POLD4 E2F6	4.86e-05	23	65	3	GO:0043601
GeneOntologyCellularComponent	replisome	POLA1 POLD4 E2F6	6.28e-05	25	65	3	GO:0030894
GeneOntologyCellularComponent	nuclear replication fork	POLA1 POLD4 E2F6	3.02e-04	42	65	3	GO:0043596
GeneOntologyCellularComponent	Ctf18 RFC-like complex	DDX12P CHTF18	4.22e-04	10	65	2	GO:0031390
Domain	DUF4592	CRACD CRACDL	3.68e-05	3	66	2	IPR028030
Domain	DUF4592	CRACD CRACDL	3.68e-05	3	66	2	PF15262
Domain	PWWP	HDGFL1 HDGF	2.24e-03	20	66	2	SM00293
Domain	P-loop_NTPase	MAGI2 RHOBTB1 HNRNPUL2 CHTF18 RHOT2 HS6ST3 ABCA9 CHST3 NLRP6	2.85e-03	848	66	9	IPR027417
Domain	PWWP	HDGFL1 HDGF	2.97e-03	23	66	2	PF00855
Domain	PWWP_dom	HDGFL1 HDGF	2.97e-03	23	66	2	IPR000313
Domain	PWWP	HDGFL1 HDGF	3.23e-03	24	66	2	PS50812
Domain	UIM_dom	PARP10 HUWE1	3.50e-03	25	66	2	IPR003903
Pathway	REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE	POLA1 CHTF18 POLD4	5.40e-05	25	42	3	MM14681
Pathway	REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE	POLA1 CHTF18 POLD4	6.10e-05	26	42	3	M29583
Pathway	REACTOME_TELOMERE_C_STRAND_LAGGING_STRAND_SYNTHESIS	POLA1 CHTF18 POLD4	1.26e-04	33	42	3	MM14683
Pathway	REACTOME_TELOMERE_C_STRAND_LAGGING_STRAND_SYNTHESIS	POLA1 CHTF18 POLD4	1.38e-04	34	42	3	M27030
Pathway	REACTOME_EXTENSION_OF_TELOMERES	POLA1 CHTF18 POLD4	3.87e-04	48	42	3	MM17213
Pathway	REACTOME_EXTENSION_OF_TELOMERES	POLA1 CHTF18 POLD4	4.64e-04	51	42	3	M14804
Pathway	REACTOME_POLYMERASE_SWITCHING	POLA1 POLD4	7.71e-04	14	42	2	M787
Pathway	REACTOME_POLYMERASE_SWITCHING	POLA1 POLD4	7.71e-04	14	42	2	MM15372
Pathway	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND	POLA1 POLD4	8.88e-04	15	42	2	MM15373
Pathway	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND	POLA1 POLD4	8.88e-04	15	42	2	M744
Pathway	REACTOME_S_PHASE	PDS5B POLA1 ANAPC2 POLD4	9.10e-04	146	42	4	MM15378
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 MAGI2 NES NCOR2 KIFBP ILF2 HDAC4 HNRNPUL2 ZBTB22 MPDZ HUWE1 SH3BP5	2.81e-07	963	67	12	28671696
Pubmed	Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4.	NCOR2 HDAC4	3.66e-06	2	67	2	30321390
Pubmed	Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor.	NCOR2 HDAC4	3.66e-06	2	67	2	26161557
Pubmed	Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations.	HDAC4 RYR1	1.10e-05	3	67	2	28007904
Pubmed	Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus.	HDGFL1 HDGF	1.10e-05	3	67	2	9299445
Pubmed	Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.	NCOR2 HDAC4	1.10e-05	3	67	2	17383980
Pubmed	Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway.	MAGI2 PDS5B	1.10e-05	3	67	2	29679339
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	FAM163B PIEZO1 ZFHX2 MICAL3 CPLANE1 RYR1 HEXIM1 KDM4B	1.10e-05	552	67	8	10737800
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TAOK2 NCOR2 RHOBTB1 ANXA2R POLA1 PIEZO1 OS9 MICAL3 PRR3 SH3BP5 HDGF	1.93e-05	1215	67	11	15146197
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	TMC1 PIEZO1	2.19e-05	4	67	2	27893727
Pubmed	Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development.	NES PIEZO1	2.19e-05	4	67	2	36069933
Pubmed	Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes.	NCOR2 HDAC4	2.19e-05	4	67	2	12205093
Pubmed	The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.	NCOR2 HDAC4	2.19e-05	4	67	2	11509652
Pubmed	Combinatorial roles of the nuclear receptor corepressor in transcription and development.	NES NCOR2	3.64e-05	5	67	2	11030619
Pubmed	The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures.	NCOR2 HDAC4	3.64e-05	5	67	2	16033423
Pubmed	Rho GTPases have diverse effects on the organization of the actin filament system.	RHOBTB1 RHOT2	3.64e-05	5	67	2	14521508
Pubmed	Expression patterns of Piezo1 in the developing mouse forebrain.	NES PIEZO1	3.64e-05	5	67	2	38411929
Pubmed	The histone deacetylase-3 complex contains nuclear receptor corepressors.	NCOR2 HDAC4	3.64e-05	5	67	2	10860984
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 HIVEP3 NCOR2 RIN3 PIEZO1 KANK3 MICAL3 RHOT2 HUWE1 RYR1	4.83e-05	1105	67	10	35748872
Pubmed	Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.	MAGI2 MPDZ	5.46e-05	6	67	2	15509766
Pubmed	Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.	NCOR2 HDAC4	5.46e-05	6	67	2	10640275
Pubmed	Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.	MAGI2 MPDZ	7.63e-05	7	67	2	24025447
Pubmed	CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.	MPDZ CLIC6	7.63e-05	7	67	2	14499480
Pubmed	Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.	NCOR2 HDAC4	7.63e-05	7	67	2	11804585
Pubmed	Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.	NCOR2 HDAC4	7.63e-05	7	67	2	10869435
Pubmed	Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2.	NCOR2 HDAC4	1.02e-04	8	67	2	17158926
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	TMC1 PIEZO1	1.02e-04	8	67	2	38228630
Pubmed	Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.	NCOR2 HDAC4	1.30e-04	9	67	2	11466315
Pubmed	Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.	NCOR2 HDAC4	1.30e-04	9	67	2	10944117
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PDS5B NCOR2 ILF2 HNRNPUL2 POLA1 CHTF18 POLD4 HEXIM1 HDGF	1.38e-04	1014	67	9	32416067
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HIVEP3 PDS5B PEG3 ZBTB22 E2F6 PRR3 KDM4B ZNF697	1.60e-04	808	67	8	20412781
Pubmed	BCoR, a novel corepressor involved in BCL-6 repression.	NCOR2 HDAC4	1.63e-04	10	67	2	10898795
Pubmed	Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum.	NES SKOR2	1.63e-04	10	67	2	20809939
Pubmed	Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication.	POLA1 POLD4	1.63e-04	10	67	2	21705323
Pubmed	Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.	NCOR2 HDAC4	1.63e-04	10	67	2	15536134
Pubmed	Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.	CRACD CRACDL	1.63e-04	10	67	2	31234534
Pubmed	RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.	POLA1 POLD4	2.38e-04	12	67	2	11473323
Pubmed	Role of Tet1 in erasure of genomic imprinting.	PEG3 DIO3	2.38e-04	12	67	2	24291790
Pubmed	Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling.	MAGI2 MPDZ	2.81e-04	13	67	2	23576434
Pubmed	Optimising experimental design for high-throughput phenotyping in mice: a case study.	MAGI2 TMC1	2.81e-04	13	67	2	20799038
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	CRACD HNRNPUL2 MICAL3	3.00e-04	67	67	3	29254152
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIVEP3 PARP10 NCOR2 HDAC4 UVSSA ZFHX2 OS9 MICAL3 HUWE1 KDM4B	5.38e-04	1489	67	10	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 KIFBP PIEZO1 UVSSA ANAPC2 KDM4B	5.48e-04	529	67	6	14621295
Pubmed	Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.	NES MPDZ	5.48e-04	18	67	2	26209645
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	MAGI2 PDS5B KIFBP TMC1 CRACDL OS9 RHOT2 SOCS7 KDM4B	6.10e-04	1242	67	9	30973865
Pubmed	Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice.	NES SKOR2	6.12e-04	19	67	2	21844226
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	BRIX1 NES NCOR2 ILF2 RHOT2 HUWE1 HEXIM1 HDGF	6.15e-04	989	67	8	36424410
Pubmed	Genomic analysis of mouse retinal development.	TAOK2 NES NCOR2 CLIP3 HNRNPUL2 RP1L1 ANAPC2 RHOT2	6.87e-04	1006	67	8	15226823
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	PARP10 FMN2 PRR3 KDM4B CHST3	7.55e-04	371	67	5	15747579
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TAOK2 MICAL3 KDM4B	9.67e-04	100	67	3	10048485
Pubmed	Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting.	PEG3 DIO3	9.82e-04	24	67	2	20168089
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	BRIX1 KIFBP ILF2 ANAPC2 PEG3 MPDZ TSPYL1 HUWE1 HEXIM1	1.02e-03	1335	67	9	29229926
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	CRACD CHTF18 MICAL3	1.08e-03	104	67	3	31240132
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDS5B NES NCOR2 ILF2 HNRNPUL2 POLA1 CHTF18 RHOT2 HUWE1	1.12e-03	1353	67	9	29467282
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MAGI2 PDS5B CRACD PEG3 MICAL3	1.14e-03	407	67	5	12693553
Pubmed	Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.	NES SKOR2	1.15e-03	26	67	2	35165395
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	PDS5B NES HUWE1 HDGF	1.32e-03	246	67	4	15345747
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	HDAC4 HUWE1	1.34e-03	28	67	2	25752541
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	NES SYNC	1.34e-03	28	67	2	25179606
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	NCOR2 ILF2 HNRNPUL2	1.38e-03	113	67	3	23403292
Pubmed	Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.	HDAC4 RYR1	1.44e-03	29	67	2	29543863
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	NCOR2 HDAC4 ZBTB22 ZNF200 E2F6 KDM4B HDGF	1.48e-03	877	67	7	20211142
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	HNRNPUL2 CHTF18 ANAPC2 MPDZ MICAL3 HEXIM1	1.58e-03	650	67	6	38777146
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	BRIX1 PDS5B KIFBP ILF2 HNRNPUL2 POLA1 HUWE1 HEXIM1 HDGF	1.60e-03	1425	67	9	30948266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BRIX1 PDS5B NES ILF2 POLA1 HUWE1	1.62e-03	653	67	6	22586326
Pubmed	The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.	KANK3 ZBTB22	1.64e-03	31	67	2	26618355
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	BRIX1 ILF2 HNRNPUL2	1.67e-03	121	67	3	34029587
Pubmed	Genome-wide association study identifies eight loci associated with blood pressure.	RHOBTB1 HEXIM1	1.75e-03	32	67	2	19430483
GeneFamily	PWWP domain containing	HDGFL1 HDGF	1.54e-03	22	48	2	1147
GeneFamily	DNA polymerases	POLA1 POLD4	1.69e-03	23	48	2	535
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	HIVEP3 PDS5B CRACD PEG3 ZFHX2 FMN2 HS6ST3 SH3BP5 ZNF697	2.44e-06	465	66	9	M39066
Coexpression	GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP	NCOR2 RIN3 ZFYVE19 PRR3 SH3BP5	1.88e-05	129	66	5	M423
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PARP10 RIN3 POLA1 CHTF18 ABCA9	2.41e-06	142	67	5	671ba8869db7a6dc69fd1caf0e561f15a312b170
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PARP10 RIN3 POLA1 CHTF18 ABCA9	2.41e-06	142	67	5	3557084150670fd2e2634fc674f228ab85181b59
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PARP10 RIN3 POLA1 CHTF18 ABCA9	2.41e-06	142	67	5	6a656d28c9f5dfb03a3a2d908cf2edbe0a5b1206
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PARP10 RIN3 POLA1 CHTF18 ABCA9	2.41e-06	142	67	5	a3d1f4b570b75402171e38c5a7c88e2896520c8f
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CRACDL DIO3 CLIC6 KLHL34 RYR1	4.32e-06	160	67	5	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CRACDL DIO3 CLIC6 KLHL34 RYR1	4.45e-06	161	67	5	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRACDL ZFHX2 MPDZ CLIC6 CPLANE1	5.97e-06	171	67	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES DIO3 FMN2	6.14e-06	172	67	5	381ae1c3c07d0a424f43455ec571653b192a946a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES DIO3 FMN2	6.50e-06	174	67	5	dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CRACDL DIO3 KLHL34 NLRP6	4.43e-05	130	67	4	c70fb77324916d220d842a575558a8245c276599
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD TMC1 FMN2	8.77e-05	155	67	4	e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD TMC1 FMN2	8.77e-05	155	67	4	5a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAOK2 PIEZO1 PEG3 ZFHX2	1.20e-04	168	67	4	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.20e-04	168	67	4	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES KANK3 SCN4A SH3BP5	1.20e-04	168	67	4	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.20e-04	168	67	4	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAOK2 PIEZO1 PEG3 ZFHX2	1.20e-04	168	67	4	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 NES CLIP3 FMN2	1.25e-04	170	67	4	60bbd738c12e64e483485586c30057304884f5a6
ToppCell	COVID-19-kidney-Podocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MAGI2 CRACD TMC1 FMN2	1.40e-04	175	67	4	a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.46e-04	177	67	4	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.49e-04	178	67	4	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD TMC1 FMN2	1.59e-04	181	67	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD TMC1 FMN2	1.59e-04	181	67	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	MAGI2 CRACD NES FMN2	1.66e-04	183	67	4	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.66e-04	183	67	4	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.66e-04	183	67	4	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.66e-04	183	67	4	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.73e-04	185	67	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.73e-04	185	67	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 CRACD NES FMN2	1.73e-04	185	67	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac\|Myeloid_cells / Location, Cell class and cell subclass	ZNF200 ZFYVE19 SYNC ZNF697	1.77e-04	186	67	4	701eea0016d69f0f9d29b613948f91239096e6c7
ToppCell	10x5'-Lung-Lymphocytic_Invariant-Inducer-like-ILC3\|Lung / Manually curated celltypes from each tissue	ANXA2R KANK3 ZNF200 MICAL3	1.81e-04	187	67	4	0e7aa481effdd8c2fbdf8b65852821dec2d92cde
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANXA2R KANK3 RP1L1 SCN4A	1.81e-04	187	67	4	50d5730e2cd4951d3ad0641fc81ae9f6ddabafe7
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANXA2R CRACDL KANK3 SH3BP5	1.88e-04	189	67	4	1d660bceee449aebf12fc9af4c74af246837b27a
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES KANK3 SCN4A MPDZ	1.92e-04	190	67	4	141266bf411ea675fbf889b20c1b08673c45ff95
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAOK2 RHOBTB1 PEG3 HUWE1	2.08e-04	194	67	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	PND01-Mesenchymal-Mesenchymal_structural\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HIVEP3 KANK3 PEG3 SH3BP5	2.12e-04	195	67	4	6bb6349d6ec8da094fe1c7c590021989337aeb0b
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NES HDGFL1 ANXA2R MPDZ	2.12e-04	195	67	4	32ec72103faccc9e37c0ecedff1998e7df6a19f6
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HIVEP3 KANK3 PEG3 SH3BP5	2.12e-04	195	67	4	a3b468125e48f072255cede7645f6692298ecf54
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAOK2 NES RIN3 KANK3	2.12e-04	195	67	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	DIO3 CLIC6 NLRP6	2.13e-04	77	67	3	10969743351c49a1d6d8ae1ef93098e7786ca3fe
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HIVEP3 KANK3 PEG3 SH3BP5	2.20e-04	197	67	4	06a0d7062dadda656decaf77dcef9a10b5f2698d
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HIVEP3 KANK3 PEG3 SH3BP5	2.20e-04	197	67	4	d35c7a36135b5ed6a7bf2f934849678eba2a0177
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CRACD CLIP3 DIO3 ABCA9	2.25e-04	198	67	4	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	medial-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES CRACDL KANK3 SH3BP5	2.33e-04	200	67	4	a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	RIN3 PIEZO1 POLD4 RYR1	2.33e-04	200	67	4	26251ed8c7fa7e87973d6f59bd398c88ad025395
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	HIVEP3 MAGI2 CRACD SOCS7	2.33e-04	200	67	4	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	medial-Endothelial-Capillary_Intermediate_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES CRACDL KANK3 SH3BP5	2.33e-04	200	67	4	3ef7b7728615710c691aed8977e2582f19692cf9
ToppCell	medial-Endothelial\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES CRACDL KANK3 SH3BP5	2.33e-04	200	67	4	e889b593c2ae53c42944213ce8672cd886917105
ToppCell	medial-2-Endothelial\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES CRACDL KANK3 SH3BP5	2.33e-04	200	67	4	70440db2d8be1e29aeb34ea5e8ac72641b5c056f
ToppCell	distal-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES CRACDL KANK3 SH3BP5	2.33e-04	200	67	4	7a99f28670ffb8ece7873d8a9bcd2a3936d0255d
ToppCell	medial-Endothelial-Capillary_Intermediate_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES CRACDL KANK3 SH3BP5	2.33e-04	200	67	4	707148e01e961097819a05437a842b7d3bf72b0a
Disease	Congenital myopathy (disorder)	SCN4A RYR1	2.65e-04	12	60	2	C0270960
Disease	alcohol use disorder measurement	MAGI2 MLN HEXIM1 KDM4B	9.55e-04	214	60	4	EFO_0009458
Disease	forced expiratory volume	NCOR2 RIN3 HDAC4 PIEZO1 SCN4A MICAL3 KDM4B	1.07e-03	789	60	7	EFO_0004314
Disease	opioid use disorder	MAGI2 CRACDL HS6ST3	1.16e-03	101	60	3	EFO_0010702

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEEAAQPLGAPEEEP	CHTF18	256	Q8WVB6
EEDEKRPAEEQPPFG	ANAPC2	576	Q9UJX6
ILPPARDEEEEEEEG	SH3BP5	16	O60239
AIFPNPEEPEGEEED	ABCA9	1246	Q8IUA7
REPAEEAADEKPPEE	CT47B1	216	P0C2W7
EPEEPAEVGAEEPAQ	CCDC96	96	Q2M329
AEEVEEEERDRIPGP	BRIX1	36	Q8TDN6
ELGEEPQPRDEEEAE	POLD4	31	Q9HCU8
ERQEEAEQRPEVPEG	CLIC6	136	Q96NY7
DGPQQEPGEDEERRE	CLIC6	361	Q96NY7
EAPVEEVGQAEEPDR	ANXA2R	101	Q3ZCQ2
EPEAQDVDPRPEAEE	ZFYVE19	401	Q96K21
PPAPEEEEEEERQSG	PDS5B	1321	Q9NTI5
PVEEGEEQKPPAAEE	NCOR2	836	Q9Y618
RGQVAAPEPEEEEEE	KLHL34	306	Q8N239
EEEGEEEEEEPRLPP	MICAL3	941	Q7RTP6
EPIESDEEEAEPPRE	HDAC4	561	P56524
DEEEAEPPREVEPGQ	HDAC4	566	P56524
PPEEEEEERPVVNGN	MAGI2	231	Q86UL8
PPQPEEEELREEEVA	HDGFL1	216	Q5TGJ6
EPEVELNSEGEEVPP	DIO3	81	P55073
EERPPPAAEGEDDEE	KIAA2026	16	Q5HYC2
EEEEEEEQPRAGPQG	DCAF8L2	141	P0C7V8
EELNPERPPGAEERV	HEXIM1	26	O94992
ERPPGAEERVPEEDS	HEXIM1	31	O94992
SGRGPPQEEEEEEDE	HDGF	206	P51858
EDEDEEPPPAQALGQ	HNRNPUL2	91	Q1KMD3
IPEGPQEEGEESREE	NES	1271	P48681
EAGPEVDPEEEEEEP	KDM4B	411	O94953
EEEEPQPLPHGREAE	KDM4B	421	O94953
QDPGEPGEAEVQEED	HUWE1	2291	Q7Z6Z7
PAPEPEREAETEPER	CRACDL	456	Q6NV74
EDGEQEQIPELPDPS	POLA1	891	P09884
AAPEEEDEEPGDPRE	HS6ST3	86	Q8IZP7
PEERAEEPEGKAEEP	PEG3	1461	Q9GZU2
PEGPEEEENPQQSEE	E2F6	261	O75461
PIEEEKPDEAPGVDR	CPLANE1	1436	Q9H799
EPPEEEEDVLNGGER	FAM163B	106	P0C2L3
EEEGEGQEPPLEAER	CRACD	271	Q6ZU35
RDGPEPEAEREPVRD	CCDC102A	171	Q96A19
EGEEEEENTEEPPQG	ILF2	366	Q12905
PEAERPEQLESGEEE	DDX12P	201	Q92771
DIRDPEPEAEAEPQQ	KANK3	526	Q6NY19
PPPRGEEEEEEEEDE	CLIP3	11	Q96DZ5
GEDAPQRLGEEPEEE	FMN2	371	Q9NZ56
AENGEKEEVPEPTPE	RYR1	4506	P21817
GPAPEDEDERPEAED	KIFBP	51	Q96EK5
PEEEEEGEEPNYPLE	NLRP6	606	P59044
ELEEEGPQEQPEEEV	PARP10	616	Q53GL7
PVPVVGKGEEEEEED	RIN3	16	Q8TB24
PDEALHVEEPGNPEE	SYNC	91	Q9H7C4
IVPRDDEGRPLDPED	UVSSA	591	Q2YD98
DPEEQAEENPEGEQP	SCN4A	976	P35499
GEEFPEEVPPRAEEI	RHOT2	26	Q8IXI1
QQPPLPEREETGDEE	PRR3	16	P79522
QGPALTPVPEEEEEE	TAOK2	891	Q9UL54
EEEEEEEGAPIGTPR	TAOK2	901	Q9UL54
SVDPEEEREEGPPRI	RHOBTB1	326	O94844
EEREEGPPRIPQADQ	RHOBTB1	331	O94844
EQPVDDAAEVPQREP	OS9	386	Q13438
RDVINEDDPEPEPED	TMC1	46	Q8TDI8
GEEEEEQRKEEEPPR	CHST3	111	Q7LGC8
EEEVEEEQGLEPPAG	ZFHX2	1716	Q9C0A1
DIPELPEREEGEGEE	MPDZ	1121	O75970
GPVDPAEPIREEENE	MLN	61	P12872
QPELEGVEAPEAEEE	RP1L1	2206	Q8IWN7
GVEAPEAEEEAQPEP	RP1L1	2211	Q8IWN7
PPEGEEIEVAEEDRL	TSPYL1	196	Q9H0U9
ERIPGEEFEEPTEGE	HIVEP3	266	Q5T1R4
VGRPPEEEDVEAAPE	SOCS7	6	O14512
PPEGEEEEEGRDPDD	SKOR2	751	Q2VWA4
NPEGEDPEREPVENE	ZNF200	161	P98182
ENRLEEEEEQPAPPV	ZNF697	126	Q5TEC3
EEEEEAVPEDPRPSA	PIEZO1	1426	Q92508
DPEKHENPEEPEEVR	THEGL	51	P0DJG4
PLVPQDPDLEEEEEE	ZBTB22	311	O15209
EEELPPEEVAGEEFP	THEG	61	Q9P2T0
VPERPGPAEEEEELE	ZFTA	381	C9JLR9