Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

ATP6V1G3 RHOBTB3 RAD54B SMARCA2 SMARCA4 DHX32 DNAH6 DNAH11 HSP90AB1 HELLS HSP90AB3P

4.21e-066146511GO:0140657
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

RAD54B SMARCA2 SMARCA4 HELLS

6.23e-0637654GO:0140658
GeneOntologyMolecularFunctionselenide, water dikinase activity

SEPHS2 SEPHS1

1.04e-052652GO:0004756
GeneOntologyMolecularFunctionphosphotransferase activity, paired acceptors

SEPHS2 SEPHS1

1.04e-052652GO:0016781
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP6V1G3 RHOBTB3 SMARCA4 DHX32 DNAH6 DNAH11 HSP90AB1 HSP90AB3P

8.91e-05441658GO:0016887
GeneOntologyMolecularFunctionhelicase activity

RAD54B SMARCA2 SMARCA4 DHX32 HELLS

1.64e-04158655GO:0004386
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

RAD54B SMARCA2 SMARCA4 HELLS

7.83e-04127654GO:0008094
GeneOntologyBiologicalProcessselenocysteine biosynthetic process

SEPHS2 SEPHS1

9.48e-062642GO:0016260
GeneOntologyCellularComponentsperm head plasma membrane

ADAM29 RHO HSP90AB1

4.44e-0611643GO:1990913
GeneOntologyCellularComponentsperm plasma membrane

ADAM29 RHO HSP90AB1

4.04e-0522643GO:0097524
GeneOntologyCellularComponentsperm head

ADAM29 RHO HSP90AB1

1.05e-0430643GO:0061827
GeneOntologyCellularComponentbBAF complex

SMARCA2 SMARCA4

4.09e-0410642GO:0140092
GeneOntologyCellularComponentnpBAF complex

SMARCA2 SMARCA4

8.20e-0414642GO:0071564
GeneOntologyCellularComponentGBAF complex

SMARCA2 SMARCA4

8.20e-0414642GO:0140288
GeneOntologyCellularComponentnBAF complex

SMARCA2 SMARCA4

1.08e-0316642GO:0071565
DomainSNF2_N

RAD54B SMARCA2 SMARCA4 HELLS

3.46e-0632614IPR000330
DomainSNF2_N

RAD54B SMARCA2 SMARCA4 HELLS

3.46e-0632614PF00176
DomainSnAC

SMARCA2 SMARCA4

1.05e-052612SM01314
DomainGln-Leu-Gln_QLQ

SMARCA2 SMARCA4

1.05e-052612IPR014978
DomainSnAC

SMARCA2 SMARCA4

1.05e-052612IPR029295
DomainSnAC

SMARCA2 SMARCA4

1.05e-052612PF14619
DomainQLQ

SMARCA2 SMARCA4

1.05e-052612SM00951
DomainQLQ

SMARCA2 SMARCA4

1.05e-052612PS51666
DomainQLQ

SMARCA2 SMARCA4

1.05e-052612PF08880
DomainSPS/SelD

SEPHS2 SEPHS1

1.05e-052612IPR004536
DomainHELICASE_CTER

RAD54B SMARCA2 SMARCA4 DHX32 HELLS

2.83e-05109615PS51194
DomainHELICASE_ATP_BIND_1

RAD54B SMARCA2 SMARCA4 DHX32 HELLS

2.83e-05109615PS51192
DomainHelicase_ATP-bd

RAD54B SMARCA2 SMARCA4 DHX32 HELLS

2.96e-05110615IPR014001
Domain-

SEPHS2 SEPHS1

3.14e-0536123.90.650.10
DomainHSA

SMARCA2 SMARCA4

6.27e-054612SM00573
DomainAIRS_C

SEPHS2 SEPHS1

6.27e-054612PF02769
DomainAIRS

SEPHS2 SEPHS1

6.27e-054612PF00586
DomainPurM-like_N

SEPHS2 SEPHS1

6.27e-054612IPR016188
DomainAIR_synth_C_dom

SEPHS2 SEPHS1

6.27e-054612IPR010918
DomainHSA

SMARCA2 SMARCA4

6.27e-054612PS51204
DomainHSA_dom

SMARCA2 SMARCA4

6.27e-054612IPR014012
DomainHSA

SMARCA2 SMARCA4

6.27e-054612PF07529
Domain-

SEPHS2 SEPHS1

6.27e-0546123.30.1330.10
DomainBRK

SMARCA2 SMARCA4

1.56e-046612SM00592
DomainBRK_domain

SMARCA2 SMARCA4

1.56e-046612IPR006576
DomainBRK

SMARCA2 SMARCA4

1.56e-046612PF07533
DomainHelicase_C

RAD54B SMARCA2 SMARCA4 HELLS

4.13e-04107614PF00271
DomainHELICc

RAD54B SMARCA2 SMARCA4 HELLS

4.13e-04107614SM00490
DomainHelicase_C

RAD54B SMARCA2 SMARCA4 HELLS

4.28e-04108614IPR001650
DomainDEXDc

RAD54B SMARCA2 SMARCA4 HELLS

4.43e-04109614SM00487
DomainRNaseA

RNASE1 RNASE13

8.00e-0413612PD000535
DomainDynein_heavy_chain_D4_dom

DNAH6 DNAH11

9.31e-0414612IPR024317
DomainDynein_HC_stalk

DNAH6 DNAH11

9.31e-0414612IPR024743
DomainDynein_heavy_dom-2

DNAH6 DNAH11

9.31e-0414612IPR013602
DomainDHC_N2

DNAH6 DNAH11

9.31e-0414612PF08393
DomainMT

DNAH6 DNAH11

9.31e-0414612PF12777
DomainAAA_8

DNAH6 DNAH11

9.31e-0414612PF12780
DomainATPase_dyneun-rel_AAA

DNAH6 DNAH11

9.31e-0414612IPR011704
DomainAAA_5

DNAH6 DNAH11

9.31e-0414612PF07728
DomainDHC_fam

DNAH6 DNAH11

1.07e-0315612IPR026983
DomainRNaseA

RNASE1 RNASE13

1.07e-0315612IPR001427
DomainRNaseA_domain

RNASE1 RNASE13

1.07e-0315612IPR023412
DomainRnaseA

RNASE1 RNASE13

1.07e-0315612PF00074
DomainDynein_heavy_dom

DNAH6 DNAH11

1.07e-0315612IPR004273
Domain-

RNASE1 RNASE13

1.07e-03156123.10.130.10
DomainDynein_heavy

DNAH6 DNAH11

1.07e-0315612PF03028
DomainDisintegrin_CS

ADAM19 ADAM29

1.22e-0316612IPR018358
DomainAcyl_Trfase/lysoPLipase

FASN PNPLA1

1.38e-0317612IPR016035
DomainADAM_CR

ADAM19 ADAM29

1.55e-0318612PF08516
Domain-

ADAM19 ADAM29

1.92e-03206124.10.70.10
DomainDisintegrin

ADAM19 ADAM29

2.12e-0321612PF00200
DomainDISIN

ADAM19 ADAM29

2.12e-0321612SM00050
Domain-

RHOBTB3 RAD54B SMARCA2 SMARCA4 DHX32 DNAH6 DNAH11 HELLS

2.83e-037466183.40.50.300
DomainBromodomain_CS

SMARCA2 SMARCA4

3.24e-0326612IPR018359
PathwayREACTOME_RETROGRADE_TRANSPORT_AT_THE_TRANS_GOLGI_NETWORK

NAA35 VPS52 RHOBTB3 USP6NL

2.06e-0549474M27653
Pubmed

Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.

SMARCA2 SMARCA4 NR1H4

2.49e-08465319805516
Pubmed

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.

SMARCA2 SMARCA4 NR1H4

2.79e-061565314701856
Pubmed

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

SMARCA2 SMARCA4

3.44e-0626528670841
Pubmed

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.

SMARCA2 SMARCA4

3.44e-06265223163725
Pubmed

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

SMARCA2 SMARCA4

3.44e-06265223076393
Pubmed

Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.

SMARCA2 SMARCA4

3.44e-0626529603422
Pubmed

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

SMARCA2 SMARCA4

3.44e-06265215576411
Pubmed

SWI/SNF gene variants and glioma risk and outcome.

SMARCA2 SMARCA4

3.44e-06265223276717
Pubmed

Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.

SMARCA2 SMARCA4

3.44e-06265227097303
Pubmed

Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

SMARCA2 SMARCA4

3.44e-06265215240517
Pubmed

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

SMARCA2 SMARCA4

3.44e-06265226564006
Pubmed

SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.

SMARCA2 SMARCA4

3.44e-06265233027072
Pubmed

SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.

SMARCA2 SMARCA4

3.44e-06265228038711
Pubmed

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

SMARCA2 SMARCA4

3.44e-06265223872584
Pubmed

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.

NDRG2 NR1H4

3.44e-06265223056173
Pubmed

Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.

SMARCA2 SMARCA4

3.44e-06265223963727
Pubmed

SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.

SMARCA2 SMARCA4

3.44e-06265212493776
Pubmed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

SMARCA2 SMARCA4

3.44e-06265231375262
Pubmed

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.

SMARCA2 SMARCA4

3.44e-06265223088494
Pubmed

Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.

SEPHS2 SEPHS1

3.44e-06265215534230
Pubmed

Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.

SMARCA2 SMARCA4

3.44e-06265217075831
Pubmed

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

SMARCA2 SMARCA4

3.44e-06265220333683
Pubmed

SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.

SMARCA2 SMARCA4

3.44e-06265234812766
Pubmed

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

SMARCA2 SMARCA4

3.44e-06265232855269
Pubmed

Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.

SMARCA2 SMARCA4

3.44e-06265230478150
Pubmed

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

SMARCA2 SMARCA4

3.44e-06265222721696
Pubmed

Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.

SMARCA2 SMARCA4

3.44e-06265218508913
Pubmed

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

SMARCA2 SMARCA4

3.44e-06265211719516
Pubmed

Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia.

SMARCA2 HELLS

3.44e-06265210910076
Pubmed

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

SMARCA2 SMARCA4

3.44e-06265225808524
Pubmed

A novel putative helicase produced in early murine lymphocytes.

SMARCA4 HELLS

3.44e-0626528647447
Pubmed

Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.

SMARCA2 SMARCA4

3.44e-06265219144648
Pubmed

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

SMARCA2 SMARCA4

3.44e-06265228706277
Pubmed

[Expression of BRG1 and BRM proteins in prostatic cancer].

SMARCA2 SMARCA4

3.44e-06265221092585
Pubmed

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.

SMARCA2 SMARCA4

3.44e-06265229391527
Pubmed

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.

SMARCA2 SMARCA4

3.44e-06265237634210
Pubmed

NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3.

RHOBTB3 NR1H4

3.44e-06265236939994
Pubmed

SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

SMARCA2 SMARCA4

3.44e-06265226551623
Pubmed

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SMARCA2 SMARCA4

3.44e-06265219458193
Pubmed

Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.

FASN FZD10

3.44e-06265232944403
Pubmed

Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

SMARCA2 SMARCA4

3.44e-0626528208605
Pubmed

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.

SMARCA2 SMARCA4

3.44e-06265234289068
Pubmed

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

SMARCA2 SMARCA4

3.44e-06265234518526
Pubmed

SMARCA family of genes.

SMARCA2 SMARCA4

3.44e-06265232312722
Pubmed

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

SMARCA2 SMARCA4

3.44e-06265226356327
Pubmed

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

SMARCA2 SMARCA4

3.44e-06265212566296
Pubmed

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

SMARCA2 SMARCA4

3.44e-06265211163203
Pubmed

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.

SMARCA2 SMARCA4

3.44e-06265212620226
Pubmed

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

SMARCA2 SMARCA4

3.44e-06265231406271
Pubmed

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

SMARCA2 SMARCA4

3.44e-06265227039070
Pubmed

Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.

SMARCA2 SMARCA4

3.44e-06265229848589
Pubmed

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.

SMARCA2 SMARCA4

3.44e-06265229273066
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

FASN SMARCA2 SMARCA4 IRS1 CPT1B NR1H4

7.53e-0625065618660489
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

ANAPC1 SMARCA4 NCBP1 ECPAS PLOD2 HSP90AB1 HELLS

8.41e-0639065717643375
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CABP1 SEPHS2 SEPHS1 ATP6V1G3 ADAM19 SMARCA2 SMARCA4 IRS1 DNAH11

8.43e-0673065934857952
Pubmed

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.

SMARCA2 SMARCA4

1.03e-05365228292935
Pubmed

Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.

SMARCA2 SMARCA4

1.03e-05365236464671
Pubmed

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

SMARCA2 SMARCA4

1.03e-05365230287812
Pubmed

Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis.

SNX27 FGFR1

1.03e-05365236029209
Pubmed

The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes.

SMARCA2 SMARCA4

1.03e-05365217938176
Pubmed

Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.

SMARCA2 SMARCA4

1.03e-05365222740088
Pubmed

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.

SMARCA2 SMARCA4

1.03e-05365215034933
Pubmed

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.

SMARCA2 SMARCA4

1.03e-05365215075294
Pubmed

A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.

SMARCA2 SMARCA4

1.03e-05365212044884
Pubmed

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.

SMARCA2 SMARCA4

1.03e-05365221518954
Pubmed

Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.

SMARCA2 SMARCA4

1.03e-05365219784067
Pubmed

FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling.

IRS1 FGFR1

1.03e-05365233007330
Pubmed

Characterization of mammary tumors from Brg1 heterozygous mice.

SMARCA2 SMARCA4

1.03e-05365217637742
Pubmed

BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.

SMARCA2 SMARCA4

1.03e-05365220571081
Pubmed

Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers.

SMARCA2 SMARCA4

1.03e-05365214603256
Pubmed

SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility†.

SMARCA2 SMARCA4

1.03e-05365236440965
Pubmed

Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2.

SMARCA2 SMARCA4

1.03e-0536529099865
Pubmed

Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.

SEPHS2 SEPHS1

1.03e-05365228414460
Pubmed

Dual role of NRSF/REST in activation and repression of the glucocorticoid response.

SMARCA2 SMARCA4

2.06e-05465217984088
Pubmed

Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.

SMARCA2 SMARCA4

2.06e-05465231906887
Pubmed

SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice.

SMARCA2 SMARCA4

2.06e-05465225904594
Pubmed

Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration.

SELE HMCN1

2.06e-05465217057786
Pubmed

BRM (SNF2alpha) expression is concomitant to the onset of vasculogenesis in early mouse postimplantation development.

SMARCA2 SMARCA4

2.06e-05465211231080
Pubmed

BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.

SMARCA2 SMARCA4

2.06e-05465215141164
Pubmed

BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.

SMARCA2 SMARCA4

2.06e-05465223897427
Pubmed

Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex.

SMARCA2 SMARCA4

2.06e-05465219781646
Pubmed

Brahma safeguards canalization of cardiac mesoderm differentiation.

SMARCA2 SMARCA4

2.06e-05465235082446
Pubmed

BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.

SMARCA2 SMARCA4

2.06e-05465228232072
Pubmed

The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes.

SMARCA2 SMARCA4

2.06e-05465233481850
Pubmed

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.

SMARCA2 SMARCA4

2.06e-0546529744861
Pubmed

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.

SMARCA2 SMARCA4

2.06e-05465224421395
Pubmed

Mammalian chromatin remodeling complex SWI/SNF is essential for enhanced expression of the albumin gene during liver development.

SMARCA2 SMARCA4

2.06e-05465216452305
Pubmed

Control of B cell development by the histone H2A deubiquitinase MYSM1.

SMARCA2 SMARCA4

2.06e-05465222169041
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

FASN ANAPC1 SMARCA2 SMARCA4 NCBP1 ECPAS BIRC6 NUP160

2.91e-0565365822586326
Pubmed

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.

SMARCA2 SMARCA4

3.43e-05565218487222
Pubmed

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).

SMARCA2 SMARCA4

3.43e-0556529843504
Pubmed

The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.

SMARCA2 SMARCA4

3.43e-05565219342595
Pubmed

Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.

SMARCA2 SMARCA4

3.43e-05565212200431
Pubmed

Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells.

SMARCA2 SMARCA4

3.43e-05565225801033
Pubmed

Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression.

SMARCA2 SMARCA4

3.43e-05565220011120
Pubmed

Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.

RAD54B SMARCA2

3.43e-05565225384516
Pubmed

Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.

SMARCA2 SMARCA4

3.43e-05565212065415
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

FASN ANAPC1 SMARCA4 SNX27 NUP160 HSP90AB1

3.72e-0533265632786267
Pubmed

A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.

SMARCA2 SMARCA4

5.13e-05665210619021
Pubmed

Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.

SMARCA2 SMARCA4

5.13e-05665216940996
GeneFamilyRibonuclease A family

RNASE1 RNASE13

4.64e-0413452723
GeneFamilyDyneins, axonemal

DNAH6 DNAH11

8.04e-0417452536
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM19 ADAM29

2.04e-032745247
CoexpressionBENPORATH_SOX2_TARGETS

VPS52 RAD54B FZD10 NCBP1 FGFR1 ECPAS NUP160 ABTB2 HSP90AB1 HELLS

1.08e-057346410M3835
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_1000

NAA35 RHOBTB3 SMARCA2 SMARCA4 PLOD2 HSP90AB1

1.93e-05184646gudmap_developingGonad_e14.5_ epididymis_1000_k2
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500

NAA35 RHOBTB3 SMARCA4 SNX27 BIRC6 ABTB2 HSP90AB1 HELLS

2.75e-05403648gudmap_developingGonad_e12.5_epididymis_500
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 IRS1 GPC5 DNAH6

4.07e-06163655cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCellCV-Mild-7|CV / Virus stimulation, Condition and Cluster

NAA35 RHOBTB3 CCDC157 ABTB2 HELLS

4.99e-0617065525ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EML6 LHFPL6 PLOD2 DNAH6 RHO

6.59e-06180655b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EML6 LHFPL6 PLOD2 DNAH6 RHO

6.59e-06180655f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LDB3 ADAM19 IRS1 FGFR1 ABTB2

8.14e-061886554d1e5f85342ae550086609d7680e32730b78b5d2
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAM19 HMCN1 SMARCA2 SMARCA4 LHFPL6

8.57e-06190655d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCelldroplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 LHFPL6 FZD10 PLOD2 HELLS

9.24e-0619365559b8186d0221fba06a16157e9d148399ed801f38
ToppCelldroplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 LHFPL6 FZD10 PLOD2 HELLS

9.24e-06193655dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCelldroplet-Pancreas-Endocrine-21m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 LHFPL6 FZD10 PLOD2 HELLS

9.24e-0619365503678162648bd5b1d65a5450b60c8863edbf95c7
ToppCelldroplet-Heart-HEART-1m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LDB3 LHFPL6 IRS1 FGFR1 NDRG2

9.96e-061966551eb14182ef26e6141f510d397b00bf8a12efda3e
ToppCell(05)_Secretory|World / shred by cell type by condition

SLC43A2 FASN RNASE1 RHOBTB3 NDRG2

9.96e-061966558032c25b51ef96aeba28cc52686a2bd45213453d
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CABP1 LDB3 LHFPL6 NDRG2 NR1H4

1.10e-05200655b22cae282591d8dead9869c2adbb9632615f50f7
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CABP1 LDB3 LHFPL6 IRS1 NDRG2

1.10e-0520065577631c471cc5d453a749784f838cfa6408caf09b
ToppCellCOVID-19_Mild-immature_Neutrophil|COVID-19_Mild / Disease condition and Cell class

RAD54B BRINP1 RHO HELLS

3.17e-05123654a6670825fd8d9f9a0111a7b68598c764c99abb0d
ToppCellCOVID-19_Mild-immature_Neutrophil-|COVID-19_Mild / Disease condition and Cell class

RAD54B BRINP1 RHO HELLS

3.17e-051236545f19b0e32509bedeb9ac6c74ac7a20750798da5e
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RHOBTB3 RAD54B CPT1B NDRG2

7.60e-0515465444d4d99b08216c0901e3bc32743fa0a8b85b5149
ToppCellTCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue-5|TCGA-Kidney / Sample_Type by Project: Shred V9

PNPLA1 PTPRO TTC36 GPC5

8.39e-0515865434b284a62cc3fb90429ce579fd8cb8a60178091b
ToppCell21-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

SELE HMCN1 FGFR1 ABTB2

8.60e-051596544f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRO EML6 IRS1 DNAH11

9.92e-051656541703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCellLPS-antiTNF-Endothelial-Mes-Like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SELE TMEM267 RAD54B FGFR1

1.02e-041666543b750d4023a0a09d86113aae5a97d84391f7b482
ToppCellControl-NK|Control / Disease group and Cell class

RHOBTB3 EML6 USP6NL ABTB2

1.06e-04168654683d389c8a1e791bfc773e63148115a21a6566db
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELE RNASE1 FGFR1 HSPA12B

1.06e-0416865437249f38f8f04ec5743097259de67b106ca2b02f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SELE RNASE1 RAD54B GPC5

1.09e-041696547c994653b0d629dfb046755d6b678452de0a15d2
ToppCellCV-Mild-7|Mild / Virus stimulation, Condition and Cluster

NAA35 RHOBTB3 CCDC157 ABTB2

1.19e-04173654c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

RNASE1 LDB3 GNS SLC12A5

1.24e-04175654bde785ff0c854646d7ab8571359e9d69a7bf013f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 HMCN1 RHOBTB3 GPC5

1.33e-041786544df6218b20c2f076c22346d23260964cc0d73e65
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHFPL6 PLOD2 DNAH6 RHO

1.33e-04178654a48739a588f361b4bc69405d7e256c11f61cf43c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 RAD54B SV2C BRINP1

1.33e-04178654674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RHOBTB3 EML6 SMARCA2 ABTB2

1.36e-04179654d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC43A2 ATP6V1G3 IRS1 DNAH11

1.39e-04180654cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 RAD54B SV2C BRINP1

1.39e-04180654fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 RAD54B SV2C BRINP1

1.39e-041806545391d23817f5cc88a0871ddb98968897c839f464
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

1.39e-0418065440f79b4455dbd1c2720dc32d9d77c70f835cecb3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

PNPLA1 PTPRO BRINP1 GPC5

1.42e-04181654c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 RHOBTB3 GPC5 DNAH6

1.45e-04182654a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

SELE LHFPL6 FZD10 HSPA12B

1.45e-04182654d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 SLC43A2 RHOBTB3 GPC5

1.45e-04182654041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 SLC43A2 RHOBTB3 GPC5

1.48e-0418365431ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LHFPL6 TRPV3 NDRG2

1.48e-04183654b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHFPL6 PLOD2 DNAH6 RHO

1.48e-041836543ebe334ad570e3525341badb558f369c61daf3d3
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RHOBTB3 LHFPL6 IRS1 FGFR1

1.48e-0418365412daaea821e49bc94a01e2496331e92a80d27339
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHFPL6 PLOD2 DNAH6 RHO

1.51e-041846549cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC43A2 IRS1 NDRG2 DNAH11

1.54e-04185654af86e75096c1812ae27a78405355957ee8043d84
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HMCN1 LHFPL6 BRINP1 FGFR1

1.54e-04185654c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

SLC43A2 USP6NL MAN1B1 HELLS

1.54e-041856541979d189c204f4c2893e3170a514ee7d5523406c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 SLC43A2 RHOBTB3 GPC5

1.54e-04185654898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHFPL6 PLOD2 DNAH6 RHO

1.54e-04185654a1b2525da018abe458908cab7268bd403ee98d92
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EML6 DNAH6 NR1H4 DNAH11

1.57e-041866545c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELE CPT1B HSPA12B SLC12A5

1.60e-041876547170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

SLC43A2 ATP6V1G3 IRS1 DNAH11

1.60e-04187654ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellIPF-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

FASN RNASE1 LHFPL6 GPC5

1.64e-041886545f5fad2773e421760e67dbace23fd1f847a2e1e0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 LHFPL6 BRINP1 DNAH6

1.64e-0418865450c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellP07-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CABP1 LDB3 LHFPL6 NDRG2

1.64e-041886546ec22b79b19d57ea187f312907819dc2d01f3efe
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 HMCN1 RHOBTB3 GPC5

1.64e-041886543cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellNS-critical-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SEPHS1 RNASE1 PLOD2 HELLS

1.71e-041906547be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCellMesenchymal-airway_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

LDB3 ADAM19 IRS1 FGFR1

1.71e-04190654645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNASE1 LDB3 NDRG2 ABTB2

1.71e-0419065407f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CABP1 LDB3 HMCN1 LHFPL6

1.71e-04190654d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LDB3 LHFPL6 NDRG2

1.71e-04190654140aca04c044cd7a93f81ff1631b00b5216d2cb1
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNASE1 LDB3 NDRG2 ABTB2

1.71e-04190654ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

HMCN1 RHOBTB3 LHFPL6 FGFR1

1.74e-041916549bbafdf316c1fa3a9f1ee30d41dd7158b5c97279
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

1.74e-04191654f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNASE1 LDB3 NDRG2 ABTB2

1.74e-041916542b056cbe2e82e056e1f798974999378460eb1d16
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

CABP1 LDB3 HMCN1 LHFPL6

1.74e-04191654fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LDB3 LHFPL6 NDRG2

1.81e-04193654469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHOBTB3 LHFPL6 FGFR1 HSPA12B

1.81e-0419365480380358f44c2f4781676ec0f1fa94d4c69080d6
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LDB3 LHFPL6 NDRG2

1.81e-04193654323d1f3f4fbeb93ba857fc135d8aa0b897f98ac5
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC43A2 TDRD5 SMARCA4 ABTB2

1.81e-04193654a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELE RNASE1 HMCN1 GPC5

1.81e-041936541f978e102a029a6beb10913052cd0a20c7253e8e
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RNASE1 PLOD2 CCDC157 HELLS

1.85e-041946545dffa578149104dda33774361e9e77b227b5f1ce
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LDB3 LHFPL6 NDRG2

1.88e-041956546e875c83f838241b5fcaf4a3249b1408d74521dc
ToppCellproximal-Epithelial-Serous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RNASE1 SV2C NDRG2 ABTB2

1.88e-0419565406b73abc1f32543f2a51db52dc6424a2a398fe0f
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type|TCGA-Adrenal / Sample_Type by Project: Shred V9

RHOBTB3 DHX32 GNS NR1H4

1.88e-04195654c3280bb6219e2eff5e24ef45aa2d76479a562122
ToppCellproximal-Epithelial-Serous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RNASE1 SV2C NDRG2 ABTB2

1.88e-04195654cb62f04f0e45bfb36eed2e7a3fc54d6d390b2ed1
ToppCellfacs-Thymus-nan-3m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC43A2 TDRD5 SMARCA4 ABTB2

1.88e-0419565479114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LDB3 LHFPL6 NDRG2

1.88e-04195654c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 LDB3 LHFPL6 NDRG2

1.88e-0419565443d372373367b71243c6ea958aedccde4478618f
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

1.88e-041956543123e02d2894c83962ba402085b5e6422ebf8c73
ToppCell15-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

RHOBTB3 IRS1 NDRG2 ABTB2

1.88e-04195654414f60bc0f0d0ecb5137bcd617fae91f0c15038a
ToppCellproximal-3-Epithelial-Serous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RNASE1 SV2C NDRG2 ABTB2

1.88e-0419565424a6a566143b04e37ad002e4c55037a0460ac2ef
ToppCelldistal-2-Endothelial-Capillary_Intermediate_2|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RNASE1 LHFPL6 HSPA12B NDRG2

1.92e-04196654b84568f940f9473269fb1b14f3b3394b269e3945
ToppCellfacs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 SMARCA2 FGFR1 NDRG2

1.92e-0419665490edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

1.92e-041966541bfc3c85ce9501f52a912e53cbded7de74572b9d
ToppCellfacs-Skin-Telogen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 SMARCA2 FGFR1 NDRG2

1.92e-04196654c936014125b2ed5f796221b74acb77b8f8359875
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Radial_glial-RG|3_mon / Sample Type, Dataset, Time_group, and Cell type.

HKDC1 FGFR1 PLOD2 DNAH11

1.92e-04196654e77461ab0f909c1d22965d99f251da49f03cbb8f
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

1.92e-04196654e02301642243df483fd066d978317c113c04692b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 HMCN1 GPC5 HSPA12B

1.92e-04196654e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HOXC10 LHFPL6 FGFR1 PLOD2

1.92e-04196654d5ed41fa111750e6b363c04cccc40a47dd774852
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 HMCN1 GPC5 HSPA12B

1.96e-04197654c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell(4)_Endothelial_cells|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

SELE RNASE1 LHFPL6 HSPA12B

1.96e-04197654dd9abb43c23e7698433e455eacbf5b23b0a756c2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

1.96e-041976544ea3f57cd88b8a6bb7cb4b9e3545c0fa8f331886
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 HMCN1 GPC5 HSPA12B

1.96e-041976542844dbcd0a673ed81c99920aa45858651a00736d
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LDB3 RAD54B HKDC1 HELLS

1.96e-0419765449689a03ab31e53386dbe15c77c09ca3a14ebf4e
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CABP1 LDB3 ADAM19 DNAH11

1.96e-04197654ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 LHFPL6 GPC5 HSPA12B

2.00e-04198654b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

2.00e-04198654688b0eb5534dde40b8630ab8a3252c816711e02e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 RHOBTB3 GPC5 NDRG2

2.00e-041986544448d13511485a44fe7b549e4b8b6ad7637db624
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 EML6 BRINP1 SLC12A5

2.00e-041986548ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellBronchial_Biopsy-Endothelial-Endothelial|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SELE RNASE1 LHFPL6 HSPA12B

2.00e-04198654d4a4e5c358d26d09ff27541ce49d0db75c1cd08e
ToppCellBronchial_Biopsy-Endothelial|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SELE RNASE1 LHFPL6 HSPA12B

2.00e-04198654ec80b05b8a1800c341b5741bf3e57213308398a7
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCA2 SMARCA4

4.33e-055622C3281201
Diseasereticulocyte count

SLC43A2 ATP6V1G3 TMEM267 RHOBTB3 EML6 SV2C IRS1 BIRC6 SLC12A5 HSP90AB1

6.00e-0510456210EFO_0007986
Diseaseobsolete_red blood cell distribution width

RNASE1 TMEM267 SMARCA2 SLC15A5 SV2C DHX32 FGFR1 BIRC6 DENND4C HSP90AB1 HELLS

1.03e-0413476211EFO_0005192
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCA2 SMARCA4

1.55e-049622DOID:0050340 (implicated_via_orthology)
DiseaseLiver Cirrhosis, Experimental

SLC43A2 PTPRO PSMB8 TTC36 LHFPL6 NDRG2 PLOD2 HELLS

2.09e-04774628C0023893
DiseaseCoffin-Siris syndrome

SMARCA2 SMARCA4

3.34e-0413622C0265338
Diseasereticulocyte measurement

SLC43A2 ATP6V1G3 TMEM267 RHOBTB3 EML6 SV2C IRS1 ECPAS BIRC6

3.36e-041053629EFO_0010700
Diseasenon-alcoholic fatty liver disease (biomarker_via_orthology)

FASN IRS1 NR1H4

3.52e-0465623DOID:0080208 (biomarker_via_orthology)
Diseaseorotic acid measurement

ABTB2 DNAH11

3.89e-0414622EFO_0010516
Diseasewellbeing measurement

FASN GALK2 PSMB8 BRINP1 GNS NUP160 SLC12A5

6.08e-04692627EFO_0007869
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

IRS1 BIRC6 HELLS

8.54e-0488623EFO_0803332
DiseaseCoronary heart disease

IRS1 DNAH11

1.16e-0324622C0010068
DiseaseCFTR mutation carrier status

ATP6V1G3 BRINP1

1.26e-0325622EFO_0021794
Diseasetestosterone measurement

FASN HMCN1 ANAPC1 SMARCA2 HKDC1 FGFR1 BIRC6 NUP160 NR1H4

1.32e-031275629EFO_0004908
Diseaseglucose metabolism disease (implicated_via_orthology)

HKDC1 IRS1

1.59e-0328622DOID:4194 (implicated_via_orthology)
Diseasemuscular atrophy (biomarker_via_orthology)

HSP90AB1 HSP90AB3P

1.70e-0329622DOID:767 (biomarker_via_orthology)
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

PTPRO NUP160

1.82e-0330622C1868672
Diseaseatopic eczema

NAA35 SMARCA4 SNX27 FGFR1

1.97e-03252624EFO_0000274

Protein segments in the cluster

PeptideGeneStartEntry
YMESVMNQLLSMVCD

ATP6V1G3

91

Q96LB4
DMMIEMRRCYSNQLV

TDRD5

501

Q8NAT2
TMRSGFMQNEITCRM

ADAM29

161

Q9UKF5
MKRSGRMNYMCPNSS

BIRC6

3466

Q9NR09
VIGMSMRICQMRNSS

BRINP1

541

O60477
LMAMCSVYQSGGVNM

ADAM19

316

Q9H013
GMCLSNMPDTRMLYG

ADAM19

401

Q9H013
MLCNSFRMSAQMNRI

DNAH11

976

Q96DT5
CTDDMLQREMMSNPF

DHX32

161

Q7L7V1
LTNMCSRPMQMALYF

DIS3L2

661

Q8IYB7
NCRDLGNCMRTMGYM

CABP1

246

Q9NZU7
CMSYLENLGSEQMMP

CCDC157

91

Q569K6
FLYECVMGMRMNGRC

RAD54B

306

Q9Y620
YIMMNKQFRNCMLTT

RHO

306

P08100
GGNCVMDMYMRRKCQ

NR1H4

176

Q96RI1
ASKLLSNMMCQYRGM

PSMB8

151

P28062
VTCLMNMMGYNTDRL

ANAPC1

661

Q9H1A4
MKAQALRDNSTMGYM

HSP90AB1

606

P08238
FSQMTSMLDILMDYC

HELLS

621

Q9NRZ9
TLREMAQMYQMSLRG

LDB3

206

O75112
EMLYMRLDTMNTTCV

NCBP1

396

Q09161
MGYCLNVMRGCLAHM

GPC5

271

P78333
AQALRDNSTMGYMMA

HSP90AB3P

481

Q58FF7
MCVTQLRLIFYMGAM

SLC43A2

331

Q8N370
KSSPMMETINMCLQY

ECPAS

1336

Q5VYK3
GELMNQSHMSCRDMY

GALK2

361

Q01415
SPSCKMVQMMRQFLY

PNPLA1

91

Q8N8W4
DRGYLPSSMETMQCM

SELE

211

P16581
SSQGMLRMSCEAMNE

HSPA12B

441

Q96MM6
RGDYMTMQMSCPRQS

IRS1

986

P35568
MMVMVEECGRYASFQ

LHFPL6

61

Q9Y693
LYMQMISLRTQNMAA

IGHV8-51-1

96

P0DTE2
ELMETCYQMNRQMET

MAN1B1

551

Q9UKM7
MALCRNAREMGVFMY

PLOD2

491

O00469
MLRLMQTTMEDAGQY

HMCN1

2441

Q96RW7
GLVSEMRSYRMSMVQ

PTPRO

1166

Q16827
MCKDIGYNMTRMPNL

FZD10

41

Q9ULW2
SFMLCVEMMRQQGTL

DNAH6

3371

Q9C0G6
KPSNCTNELYMMMRD

FGFR1

721

P11362
MSSIYQNCAMEVLMS

DENND4C

1476

Q5VZ89
MYMQSGSDFNCGVMR

HOXC10

31

Q9NYD6
GKMNYRLMMLQSCSG

GNS

501

P15586
MMCVSYGRMEDLVFS

EML6

866

Q6ZMW3
TLVGYSMVGCQRAMM

FASN

126

P49327
SMVGCQRAMMANRLS

FASN

131

P49327
MCIMQIPSGYYLQTM

SLC15A5

321

A6NIM6
IVPMCSYQMERMFNT

CPT1B

301

Q92523
RCEVMAAMFNGNYME

RHOBTB3

441

O94955
AAAMLNNMRVYGTCV

SLC12A5

246

Q9H2X9
TSESMMIGMLCLYNG

SV2C

631

Q496J9
LFCQMTSLMTIMEDY

SMARCA2

1071

P51531
IAGTGSNMCYMEDMR

HKDC1

676

Q2TB90
LQGMGYMASSCMTRL

NDRG2

311

Q9UN36
LFCQMTSLMTIMEDY

SMARCA4

1101

P51532
LYAMGVTECDNMLML

SEPHS1

111

P49903
MSVIMEMSCYNLQSP

NUP160

621

Q12769
STYCNQMMRRRNMTQ

RNASE1

51

P07998
LMYACAAGDEAMVQM

ABTB2

526

Q8N961
NNYDMMLGVLMERAA

VPS52

566

Q8N1B4
YCNGLMSYMRGKMQN

RNASE13

51

Q5GAN3
DLYAMGITECDNMLM

SEPHS2

161

Q99611
CQGMSQITALLLMYM

USP6NL

186

Q92738
ITMSQAYQNMCAGMF

NAA35

576

Q5VZE5
AYQNMCAGMFKTMVA

NAA35

581

Q5VZE5
MVMYLNMLRTCEGYN

SNX27

411

Q96L92
PYAALCNRMLADMMG

TTC36

166

A6NLP5
TRGFQSMGMYSVMIQ

TRPV3

566

Q8NET8
QSQGMMRAAEMCYRK

TTC37

1411

Q6PGP7
ICSFVMYLTGTRQMM

TMEM267

191

Q0VDI3