Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA helicase activity	DHX15 YTHDC2 TDRD9 DDX27 DHX8	3.16e-07	78	37	5	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX15 YTHDC2 TDRD9 DDX27 DHX8	3.59e-07	80	37	5	GO:0008186
GeneOntologyMolecularFunction	ATP hydrolysis activity	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	1.17e-06	441	37	8	GO:0016887
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	DHX15 YTHDC2 ZC3H12A TDRD9 DDX27 POLR2A DHX8	9.87e-06	417	37	7	GO:0140098
GeneOntologyMolecularFunction	helicase activity	DHX15 YTHDC2 TDRD9 DDX27 DHX8	1.03e-05	158	37	5	GO:0004386
GeneOntologyMolecularFunction	ATP-dependent activity	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	1.34e-05	614	37	8	GO:0140657
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	7.05e-05	775	37	8	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	1.23e-04	839	37	8	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	1.24e-04	840	37	8	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	1.24e-04	840	37	8	GO:0016818
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DHX15 YTHDC2 ZC3H12A TDRD9 DDX27 POLR2A DHX8	1.57e-04	645	37	7	GO:0140640
Domain	HA2	DHX15 YTHDC2 TDRD9 DHX8	3.91e-08	18	37	4	SM00847
Domain	HA2	DHX15 YTHDC2 TDRD9 DHX8	3.91e-08	18	37	4	PF04408
Domain	Helicase-assoc_dom	DHX15 YTHDC2 TDRD9 DHX8	3.91e-08	18	37	4	IPR007502
Domain	DEAD/DEAH_box_helicase_dom	DHX15 YTHDC2 TDRD9 DDX27 DHX8	3.14e-07	73	37	5	IPR011545
Domain	DEAD	DHX15 YTHDC2 TDRD9 DDX27 DHX8	3.14e-07	73	37	5	PF00270
Domain	Helicase_C	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.12e-06	107	37	5	PF00271
Domain	HELICc	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.12e-06	107	37	5	SM00490
Domain	Helicase_C	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.22e-06	108	37	5	IPR001650
Domain	HELICASE_CTER	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.32e-06	109	37	5	PS51194
Domain	HELICASE_ATP_BIND_1	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.32e-06	109	37	5	PS51192
Domain	DEXDc	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.32e-06	109	37	5	SM00487
Domain	Helicase_ATP-bd	DHX15 YTHDC2 TDRD9 DDX27 DHX8	2.43e-06	110	37	5	IPR014001
Domain	GSK3-bd	FRAT1 FRAT2	3.82e-06	2	37	2	IPR008014
Domain	GSK-3_bind	FRAT1 FRAT2	3.82e-06	2	37	2	PF05350
Domain	DUF1605	DHX15 YTHDC2 DHX8	4.77e-06	17	37	3	IPR011709
Domain	OB_NTP_bind	DHX15 YTHDC2 DHX8	4.77e-06	17	37	3	PF07717
Domain	DEAH_ATP_HELICASE	DHX15 YTHDC2 DHX8	5.76e-05	38	37	3	PS00690
Domain	P-loop_NTPase	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 TDRD9 DDX27 DHX8	2.09e-04	848	37	8	IPR027417
Domain	TSP_1	CFP ADAMTS4 SSPOP	2.62e-04	63	37	3	PF00090
Domain	TSP1	CFP ADAMTS4 SSPOP	2.87e-04	65	37	3	SM00209
Domain	TSP1_rpt	CFP ADAMTS4 SSPOP	2.87e-04	65	37	3	IPR000884
Domain	TSP1	CFP ADAMTS4 SSPOP	2.87e-04	65	37	3	PS50092
Domain	-	DHX15 PSMC6 ATP6V1A YTHDC2 TDRD9 DDX27 DHX8	5.69e-04	746	37	7	3.40.50.300
Domain	DNA/RNA_helicase_DEAH_CS	DHX15 DHX8	2.18e-03	35	37	2	IPR002464
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	CFP ADAMTS4 SSPOP	6.81e-05	39	29	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	CFP ADAMTS4 SSPOP	6.81e-05	39	29	3	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT15 CFP ADAMTS4 SSPOP	6.92e-05	109	29	4	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT15 CFP ADAMTS4 SSPOP	7.43e-05	111	29	4	M27416
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	CFP ADAMTS4 SSPOP	3.59e-04	68	29	3	M27303
Pathway	PID_NFKAPPAB_ATYPICAL_PATHWAY	REL SSPOP	5.45e-04	17	29	2	M26
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	FRAT1 FRAT2	5.45e-04	17	29	2	M27083
Pathway	REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX	PSMC6 FRAT1 FRAT2	5.57e-04	79	29	3	MM14754
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	FRAT1 FRAT2	6.13e-04	18	29	2	MM14759
Pathway	REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX	PSMC6 FRAT1 FRAT2	6.90e-04	85	29	3	M27079
Pubmed	Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.	DHX15 DHX8	1.10e-06	2	37	2	7935475
Pubmed	Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells.	FRAT1 FRAT2	3.30e-06	3	37	2	22064483
Pubmed	Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.	FRAT1 FRAT2	3.30e-06	3	37	2	12095675
Pubmed	Characterization and functional analysis of the murine Frat2 gene.	FRAT1 FRAT2	3.30e-06	3	37	2	15073180
Pubmed	The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.	FRAT1 FRAT2	6.60e-06	4	37	2	36153370
Pubmed	Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43.	DHX15 DHX8	6.60e-06	4	37	2	9342318
Pubmed	The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.	FRAT1 FRAT2	6.60e-06	4	37	2	11738041
Pubmed	Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.	REL ZC3H12A	6.60e-06	4	37	2	23706741
Pubmed	Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.	FRAT1 FRAT2	1.10e-05	5	37	2	19802005
Pubmed	Frat is dispensable for canonical Wnt signaling in mammals.	FRAT1 FRAT2	1.65e-05	6	37	2	15681612
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	DHX15 PSMC6 DDX27 POLR2A	1.67e-05	144	37	4	35681168
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	YTHDC2 KIF23 DDX27 POLR2A DHX8	2.61e-05	332	37	5	25693804
Pubmed	The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.	DHX15 DHX8	3.07e-05	8	37	2	35263596
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	DHX15 PSMC6 ATP6V1A KIF23 ARVCF DDX27 POLR2A DHX8	4.08e-05	1247	37	8	27684187
Pubmed	Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors.	REL CD3D	6.02e-05	11	37	2	9510190
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX15 YTHDC2 KIF23 DDX27 POLR2A DHX8	6.06e-05	653	37	6	22586326
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	CFP ADAMTS4 SSPOP	7.10e-05	75	37	3	20637190
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	DHX15 PSMC6 POLR2A HASPIN	7.43e-05	211	37	4	17314511
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	YTHDC2 KIF23 DDX27 POLR2A HASPIN	9.89e-05	440	37	5	34244565
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DHX15 PSMC6 ATP6V1A YTHDC2 KIF23 DDX27 POLR2A DHX8	1.04e-04	1425	37	8	30948266
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	PSMC6 ATP6V1A YTHDC2 FRAT2 PRSS12 DDX27	1.14e-04	732	37	6	34732716
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	FRAT1 POLR2A	1.67e-04	18	37	2	21343540
Pubmed	SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.	DHH WTIP	2.51e-04	22	37	2	37039821
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	DHX15 KIF23 POLR2A DHX8	2.86e-04	300	37	4	28561026
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX15 PSMC6 KIF23 CORO7 ARVCF DDX27 POLR2A	4.91e-04	1353	37	7	29467282
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	DHX15 ATP6V1A KIF23 CORO7	5.52e-04	357	37	4	37059091
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT15 ADAMTS4	6.78e-04	36	37	2	25615642
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX15 ATP6V1A YTHDC2 DDX27 POLR2A DHX8	6.84e-04	1024	37	6	24711643
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	THEMIS2 TMEM39B DENND2D ADAMTS4 EPHA8 ASH1L	7.08e-04	1031	37	6	16710414
Pubmed	A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin.	DHX15 POLR2A	7.16e-04	37	37	2	18562274
Pubmed	RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.	RITA1 PSMC6	7.16e-04	37	37	2	35701858
Pubmed	Association of gene polymorphisms with chronic kidney disease in Japanese individuals.	ARVCF JPH3	7.96e-04	39	37	2	19724895
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	DHX15 KIF23 POLR2A	8.87e-04	177	37	3	26206133
Cytoband	10q24.1	FRAT1 FRAT2	1.45e-04	22	37	2	10q24.1
GeneFamily	DEAH-box helicases	DHX15 DHX8	2.18e-04	16	25	2	500
Coexpression	GSE46606_IRF4MID_VS_WT_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_UP	DHX15 REL ZC3H12A ADAMTS4 SSPOP	8.79e-06	200	37	5	M9856
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD3D TDRD9 WTIP AOC2	9.28e-06	160	37	4	c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP KIF23 FRAT1 DHX8	1.29e-05	174	37	4	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZC3H12A DENND2D FRAT1 FRAT2	1.35e-05	176	37	4	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THEMIS2 REL CFP FRAT1	1.35e-05	176	37	4	a31d7532f8c055d4e62bbaa78d819f2495bfee00
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD3D KIF23 DENND2D PENK	1.35e-05	176	37	4	91ad2c34144f72283ca112fd3b3784f2f6259f65
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REL ADAMTS4 POLR2A ASH1L	1.64e-05	185	37	4	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CD3D AHRR SSPOP PENK	1.71e-05	187	37	4	f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCell	Smart-seq2-spleen_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	THEMIS2 REL ZC3H12A DDX27	1.79e-05	189	37	4	b0244a9d1b5c8ad4708750b691184f3491b13900
ToppCell	Parenchyma_COVID-19-Immune-TX-MoAM-4\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	THEMIS2 ATP6V1A FRAT1 FRAT2	2.14e-05	198	37	4	a7eed9eeb728a8796e2780090cc244856efd8c65
Disease	Lewy body dementia	JPH3 DHX8 ASH1L	1.48e-05	39	36	3	EFO_0006792
Disease	refractive error, age at onset, Myopia	GALNT15 TDRD9 POLR2A	1.68e-03	193	36	3	EFO_0004847, HP_0000545, MONDO_0004892
Disease	congenital heart disease	YTHDC2 PRSS12	2.37e-03	59	36	2	EFO_0005207
Disease	cardiomyopathy (implicated_via_orthology)	KLF15 JPH3	3.41e-03	71	36	2	DOID:0050700 (implicated_via_orthology)
Disease	sudden cardiac arrest	GALNT15 YTHDC2	4.63e-03	83	36	2	EFO_0004278
Disease	monocyte count	THEMIS2 ZC3H12A ARVCF FRAT1 FRAT2 ASH1L	4.88e-03	1320	36	6	EFO_0005091
Disease	pulse pressure measurement	DHX15 CD3D CORO7 ARVCF SSPOP DHX8	6.30e-03	1392	36	6	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPPGECTYAGRKRRR	AHRR	6	A9YTQ3
YGRKSPVGRDVCRLR	ASH1L	2526	Q9NR48
GKRILDPRGIYRCNG	CD3D	61	P04234
DYGTATRRRPECGRG	ARVCF	281	O00192
QRKRGCGAARRGPRS	ACBD4	211	Q8NC06
GRAGRTRPGKCFRLY	DHX15	471	O43143
RRRGGCEKLRAGPQA	DDX27	6	Q96GQ7
LQKRYGGFMRRVGRP	PENK	206	P01210
GRNSRGLVRGVDCPY	AOC2	386	O75106
VICRQLGYKGPARAR	PRSS12	536	P56730
GRRGGSYRLIKQPRR	GALNT15	111	Q8N3T1
CKDGRVRVYRPRSGP	CORO7	656	P57737
MTEGTCLRRRGGPYK	LSS	1	P48449
PGQQSRGRTCRGRKF	CFP	341	P27918
VPRNGGKYCEGRRTR	ADAMTS4	551	O75173
GRGPVGRRRYARKQL	DHH	26	O43323
SGEVCYGRLRVPGQR	EPHA8	646	P29322
YGAADGRRQRRPGRE	HASPIN	16	Q8TF76
GDRGRVRGRAAPYCV	FRAT1	116	Q92837
KCPVGYLGDRLVGRR	KLF15	16	Q9UIH9
GYTSRGKIGCTQPRR	DHX8	606	Q14562
QRAGRAGRTGPGKCY	DHX8	886	Q14562
GSRKIGYCRRLLPAG	DENND2D	131	Q9H6A0
GDRGRVRGRAAPYCV	FRAT2	116	O75474
ICGLTPGRRYRNQPR	KIF23	446	Q02241
PCGGGYRNRTRGSSR	SSPOP	3056	A2VEC9
NQRKGRAGRVSRGYC	TDRD9	491	Q8NDG6
GLQHRCRGGYRVKAR	RITA1	16	Q96K30
TPSRRVGGKRVVCYD	ZC3H12A	211	Q5D1E8
HGGCGRYQPRIRRSG	POLR2A	181	P24928
VSGGYQGKLRRRPRE	THEMIS2	316	Q5TEJ8
YERAGRVKCLGNPER	ATP6V1A	386	P38606
PRQRGMRFRYKCEGR	REL	16	Q04864
RKGRAGRCRPGICFR	YTHDC2	736	Q9H6S0
VKATNGPRYVVGCRR	PSMC6	71	P62333
GPRYVVGCRRQLDKS	PSMC6	76	P62333
CGRRLRGKAFYNVGE	WTIP	256	A6NIX2
MGGRRGPNRTSYCRN	TMEM39B	1	Q9GZU3
QKRRYSKGGACRGLG	JPH3	626	Q8WXH2