Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentintegrin complex

ITGB3 ITGBL1

5.14e-0432222GO:0008305
GeneOntologyCellularComponentprotein complex involved in cell adhesion

ITGB3 ITGBL1

1.74e-0359222GO:0098636
GeneOntologyCellularComponentSCF ubiquitin ligase complex

CCNF FBXL5

2.45e-0370222GO:0019005
GeneOntologyCellularComponenthistone methyltransferase complex

TAF1L CXXC1

2.80e-0375222GO:0035097
GeneOntologyCellularComponentmethyltransferase complex

TAF1L CXXC1

5.71e-03108222GO:0034708
DomainEGF_extracell

TENM1 ITGB3 ITGBL1 MEGF10 TENM4

5.64e-0960215IPR013111
DomainEGF_2

TENM1 ITGB3 ITGBL1 MEGF10 TENM4

5.64e-0960215PF07974
DomainTox-GHH_dom

TENM1 TENM4

7.21e-064212IPR028916
DomainTENEURIN_N

TENM1 TENM4

7.21e-064212PS51361
DomainTen_N

TENM1 TENM4

7.21e-064212IPR009471
DomainTox-GHH

TENM1 TENM4

7.21e-064212PF15636
DomainTen_N

TENM1 TENM4

7.21e-064212PF06484
DomainEGF_1

TENM1 ITGB3 ITGBL1 MEGF10 TENM4

7.76e-06255215PS00022
DomainEGF_2

TENM1 ITGB3 ITGBL1 MEGF10 TENM4

9.36e-06265215PS01186
DomainYD

TENM1 TENM4

1.20e-055212IPR006530
DomainL6_membrane

TM4SF4 TM4SF1

1.80e-056212PF05805
DomainL6_membrane

TM4SF4 TM4SF1

1.80e-056212IPR008661
DomainIntegrin_bsu

ITGB3 ITGBL1

4.31e-059212IPR015812
DomainINTEGRIN_BETA

ITGB3 ITGBL1

4.31e-059212PS00243
DomainNHL

TENM1 TENM4

9.32e-0513212PS51125
DomainEGF

TENM1 ITGBL1 MEGF10 TENM4

1.24e-04235214SM00181
DomainEGF-like_dom

TENM1 ITGBL1 MEGF10 TENM4

1.54e-04249214IPR000742
DomainEGF-like_CS

TENM1 ITGB3 MEGF10 TENM4

1.85e-04261214IPR013032
Domainzf-CCHC

ZCCHC9 CPSF4

3.00e-0423212PF00098
Domain-

ZCCHC9 CPSF4

3.85e-04262124.10.60.10
DomainZF_CCHC

ZCCHC9 CPSF4

7.01e-0435212PS50158
Domain-

TENM1 TENM4

8.70e-04392122.120.10.30
Domain6-blade_b-propeller_TolB-like

TENM1 TENM4

1.21e-0346212IPR011042
DomainZnF_C3H1

U2AF1 CPSF4

1.32e-0348212SM00356
Domainzf-CCCH

U2AF1 CPSF4

1.37e-0349212PF00642
DomainFBOX

CCNF FBXL5

1.54e-0352212SM00256
DomainZnF_C2HC

ZCCHC9 CPSF4

1.72e-0355212SM00343
DomainZnf_CCHC

ZCCHC9 CPSF4

1.72e-0355212IPR001878
DomainZnf_CCCH

U2AF1 CPSF4

1.92e-0358212IPR000571
DomainZF_C3H1

U2AF1 CPSF4

1.92e-0358212PS50103
DomainEGF_3

TENM1 MEGF10 TENM4

2.21e-03235213PS50026
DomainZinc_finger_PHD-type_CS

CXXC1 MLLT6

2.40e-0365212IPR019786
DomainF-box

CCNF FBXL5

2.55e-0367212PF00646
DomainFBOX

CCNF FBXL5

2.94e-0372212PS50181
DomainPHD

CXXC1 MLLT6

3.18e-0375212PF00628
DomainF-box_dom

CCNF FBXL5

3.18e-0375212IPR001810
DomainZnf_PHD-finger

CXXC1 MLLT6

3.52e-0379212IPR019787
DomainPHD

CXXC1 MLLT6

4.45e-0389212SM00249
DomainZnf_PHD

CXXC1 MLLT6

4.64e-0391212IPR001965
DomainZF_PHD_2

CXXC1 MLLT6

5.05e-0395212PS50016
DomainZF_PHD_1

CXXC1 MLLT6

5.15e-0396212PS01359
DomainZnf_FYVE_PHD

CXXC1 MLLT6

1.17e-02147212IPR011011
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

ITGB3 VAV2

1.79e-0419152MM15113
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

ITGB3 VAV2

2.19e-0421152M878
PathwayPID_NECTIN_PATHWAY

ITGB3 VAV2

4.52e-0430152M72
Pubmed

Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.

TM4SF4 TM4SF1

1.15e-06322228129652
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM1 TENM4

2.29e-06422212000766
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM1 TENM4

2.29e-06422210225957
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM1 TENM4

8.01e-06722212915301
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM1 TENM4

1.07e-05822210331952
Pubmed

Identification of genes regulated by an interaction between alphavbeta3 integrin and vitronectin in murine decidua.

CCNF ITGB3

1.37e-05922218255021
Pubmed

Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.

ITGB3 VAV2

1.71e-051022222027834
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

TENM1 TENM4

1.71e-051022238713721
Pubmed

The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

TM4SF4 TM4SF1

2.51e-051222221750032
Pubmed

Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.

U2AF1 CPSF4

5.16e-051722211060040
Pubmed

Complexes of tetraspanins with integrins: more than meets the eye.

TM4SF4 TM4SF1

1.05e-042422211739647
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

TAF1L VAV2

1.76e-043122225838543
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

ITGB3 VAV2 MEGF10

2.62e-0419922323382691
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

CXXC1 U2AF1 ITGBL1 MLLT6 VAV2

3.75e-04102122526760575
Pubmed

Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.

TENM1 TENM4

4.78e-045122216919471
Pubmed

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.

CCNF FBXL5

5.56e-045522237028429
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

TAF1L U2AF1 CPSF4

6.32e-0426922329511261
CytobandEnsembl 112 genes in cytogenetic band chr3q25

TM4SF4 TM4SF1

3.35e-03180222chr3q25
GeneFamilyCD molecules|Integrin beta subunits

ITGB3 ITGBL1

2.31e-0591521159
GeneFamilyPHD finger proteins

CXXC1 MLLT6

2.47e-039015288
CoexpressionAMIT_EGF_RESPONSE_240_HELA

TM4SF1 VAV2 SPRED2

1.62e-0559223M7714
ToppCell368C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

TENM1 ITGBL1 ZNF615 TENM4

1.33e-0616922458098f8801ca941aeddafb47e88ab0df8b9edb57
ToppCell368C-Fibroblasts-Fibroblast-B_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

TENM1 ITGBL1 ZNF615 TENM4

1.33e-061692241d5ce2c97f7ef7bdc9f861938077a9aa31d84db6
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

8.58e-05176223682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

9.79e-051842232ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.01e-0418622396f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.08e-0419022326843ec1d19ac85a50990705353b802745d33e4d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.08e-041902233f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.08e-04190223d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.08e-04190223305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.08e-04190223e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 ITGB3 PRRT4

1.11e-04192223a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGBL1 MEGF10 TENM4

1.11e-0419222367e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.11e-04192223bf1943715085c4124b1675888b0615c9500ec888
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.13e-0419322353bcd50892c379b2a571751f6eb1062436339fe7
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.13e-04193223010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.13e-041932235581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.14e-04194223e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.14e-041942231bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.14e-0419422302a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PRRT4 VAV2

1.18e-041962237af6c5147ac859353504d19727dbe24f63a29dd4
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 ITGBL1 TENM4

1.20e-0419722344673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PRRT4 VAV2

1.25e-04200223347a510755374c6a66acee326565dfc447993f18
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PRRT4 VAV2

1.25e-04200223f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PRRT4 VAV2

1.25e-042002231639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PRRT4 VAV2

1.25e-042002239ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PRRT4 VAV2

1.25e-0420022370a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 ITGBL1 TENM4

1.25e-04200223fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PRRT4 VAV2

1.25e-0420022345ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ComputationalNeighborhood of CCNF

CCNF CPSF4 SPRED2

1.26e-0478143MORF_CCNF
ComputationalNeighborhood of PPP5C

CCNF CPSF4 SPRED2

2.00e-0491143MORF_PPP5C
ComputationalNeighborhood of RAP1A

CCNF CPSF4 SPRED2

7.09e-04140143MORF_RAP1A
ComputationalImmune response genes.

ITGB3 LIMK2

8.63e-0434142MODULE_522
ComputationalNeighborhood of CSNK1A1

LARS1 FBXL5

9.68e-0436142GCM_CSNK1A1
ComputationalGenes in the cancer module 453.

CCNF VAV2

1.44e-0344142MODULE_453
Diseasemajor depressive episode, major depressive disorder

TM4SF4 TENM4

2.83e-0435212EFO_0007634, MONDO_0002009
Diseasemajor depressive episode

CCNF TENM4

5.12e-0447212EFO_0007634
Diseaseresponse to antipsychotic drug

MEGF10 TENM4

8.33e-0460212GO_0097332
Diseasefish consumption measurement

LIMK2 TENM4

9.47e-0464212EFO_0010139
Diseaseinfluenza A (H1N1)

PNLIPRP3 SPRED2

1.74e-0387212EFO_1001488
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

ZNF615 TENM4

2.33e-03101212EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Diseaseserum IgG glycosylation measurement

ITGB3 VAV2 MEGF10

5.81e-03523213EFO_0005193
Diseaseempathy measurement

ZCCHC9 TENM4

6.45e-03170212EFO_0009183
Diseasemultiple sclerosis

LIMK2 VAV2 SPRED2

8.24e-03594213MONDO_0005301
DiseaseProstatic Neoplasms

TAF1L ITGB3 U2AF1

9.10e-03616213C0033578
DiseaseMalignant neoplasm of prostate

TAF1L ITGB3 U2AF1

9.10e-03616213C0376358
Diseasebasophil count, eosinophil count

LIMK2 SPRED2

1.26e-02241212EFO_0004842, EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
KAASGACMTCNRHGC

MLLT6

131

P55198
CRTGFMGRHCEQKCP

MEGF10

776

Q96KG7
NCFFCSKEGCPTMGH

PNLIPRP3

311

Q17RR3
GKFGEFCHGCSLLMT

LIMK2

66

P53671
CGHCDFCRDMKKFGG

CXXC1

181

Q9P0U4
MGSGGVVHCRCAKCF

CCNF

1

P41002
RYKGEMCSGHGQCSC

ITGB3

556

P05106
CEFFLKAACGKGGMC

CPSF4

41

O95639
CGHSFCCTGTALRTM

FBXL5

546

Q9UKA1
CGVCICHVTEPGMFF

ITGBL1

71

O95965
GKCCLFPFGLHCTGM

LARS1

81

Q9P2J5
LKCGACGAIGHMRTN

TAF1L

1281

Q8IZX4
CFGHGTCIMGVCICV

TENM1

601

Q9UKZ4
TCSECGKGFSMKHCL

ZNF615

401

Q8N8J6
MARHGCLGLGLFCCV

PRRT4

1

C9JH25
CSGNGQYMKGRCLCH

TENM4

601

Q6N022
YHCGVMCRCCGGKHK

SPRED2

401

Q7Z698
GECTRGGFCNFMHLK

U2AF1

161

Q01081
MCYGKCARCIGHSLV

TM4SF1

1

P30408
CFVCGEMGHLSRSCP

ZCCHC9

186

Q8N567
GYMCTKCGVGAHKEC

VAV2

551

P52735
GCCGNEGCGKRFAMF

TM4SF4

76

P48230