Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP6 LDLR	3.13e-04	16	33	2	GO:0005041
GeneOntologyMolecularFunction	apolipoprotein binding	LRP4 LRP6	4.94e-04	20	33	2	GO:0034185
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP6 LDLR	5.45e-04	21	33	2	GO:0030228
GeneOntologyMolecularFunction	molecular function activator activity	VEGFC MACC1 FAM47E EGF PSME4 CBX8 TBC1D9 PENK	7.16e-04	1233	33	8	GO:0140677
GeneOntologyCellularComponent	NuRD complex	MTA1 MTA3	3.04e-04	17	32	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	MTA1 MTA3	3.04e-04	17	32	2	GO:0090545
MousePheno	abnormal circulating LDL cholesterol level	LRP6 MTA1 MTA3 MOGAT2 LDLR	5.76e-06	163	23	5	MP:0000181
MousePheno	abnormal circulating non-HDL cholesterol level	LRP6 MTA1 MTA3 MOGAT2 LDLR	9.33e-06	180	23	5	MP:0020151
MousePheno	abnormal brown fat cell number	LRP6 MOGAT2	7.21e-05	8	23	2	MP:0009126
Domain	Ldl_recept_b	LRP4 LRP6 EGF LDLR	7.98e-09	14	33	4	PF00058
Domain	LDLRB	LRP4 LRP6 EGF LDLR	7.98e-09	14	33	4	PS51120
Domain	LY	LRP4 LRP6 EGF LDLR	1.09e-08	15	33	4	SM00135
Domain	LDLR_classB_rpt	LRP4 LRP6 EGF LDLR	1.09e-08	15	33	4	IPR000033
Domain	-	LRP4 LRP6 EGF LDLR	6.36e-07	39	33	4	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	LRP4 LRP6 EGF LDLR	1.25e-06	46	33	4	IPR011042
Domain	LDLR_class-A_CS	LRP4 LRP6 LDLR	4.75e-05	40	33	3	IPR023415
Domain	Ldl_recept_a	LRP4 LRP6 LDLR	6.78e-05	45	33	3	PF00057
Domain	-	LRP4 LRP6 LDLR	7.24e-05	46	33	3	4.10.400.10
Domain	LDLRA_1	LRP4 LRP6 LDLR	8.23e-05	48	33	3	PS01209
Domain	LDrepeatLR_classA_rpt	LRP4 LRP6 LDLR	8.76e-05	49	33	3	IPR002172
Domain	LDLa	LRP4 LRP6 LDLR	8.76e-05	49	33	3	SM00192
Domain	LDLRA_2	LRP4 LRP6 LDLR	8.76e-05	49	33	3	PS50068
Domain	BAH	MTA1 MTA3	1.65e-04	11	33	2	SM00439
Domain	BAH	MTA1 MTA3	1.65e-04	11	33	2	PF01426
Domain	BAH_dom	MTA1 MTA3	1.65e-04	11	33	2	IPR001025
Domain	BAH	MTA1 MTA3	1.65e-04	11	33	2	PS51038
Domain	ZnF_GATA	MTA1 MTA3	1.98e-04	12	33	2	SM00401
Domain	ELM2	MTA1 MTA3	2.33e-04	13	33	2	SM01189
Domain	ELM2	MTA1 MTA3	2.33e-04	13	33	2	PF01448
Domain	ELM2	MTA1 MTA3	2.33e-04	13	33	2	PS51156
Domain	ELM2_dom	MTA1 MTA3	2.33e-04	13	33	2	IPR000949
Domain	Znf_GATA	MTA1 MTA3	3.13e-04	15	33	2	IPR000679
Domain	GATA	MTA1 MTA3	3.13e-04	15	33	2	PF00320
Domain	GATA_ZN_FINGER_1	MTA1 MTA3	3.58e-04	16	33	2	PS00344
Domain	GATA_ZN_FINGER_2	MTA1 MTA3	3.58e-04	16	33	2	PS50114
Domain	Chromodomain_CS	SUV39H2 CBX8	4.55e-04	18	33	2	IPR023779
Domain	EGF_CA	LRP4 EGF LDLR	4.65e-04	86	33	3	PF07645
Domain	EGF_Ca-bd_CS	LRP4 EGF LDLR	6.62e-04	97	33	3	IPR018097
Domain	EGF_CA	LRP4 EGF LDLR	7.02e-04	99	33	3	PS01187
Domain	ASX_HYDROXYL	LRP4 EGF LDLR	7.23e-04	100	33	3	PS00010
Domain	EGF_3	LRP4 LRP6 EGF LDLR	7.51e-04	235	33	4	PS50026
Domain	EGF	LRP4 LRP6 EGF LDLR	7.51e-04	235	33	4	SM00181
Domain	Chromo_domain	SUV39H2 CBX8	8.15e-04	24	33	2	IPR023780
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP4 EGF LDLR	8.57e-04	106	33	3	IPR000152
Domain	EGF-like_dom	LRP4 LRP6 EGF LDLR	9.31e-04	249	33	4	IPR000742
Domain	Chromo	SUV39H2 CBX8	9.58e-04	26	33	2	PF00385
Domain	SANT_dom	MTA1 MTA3	9.58e-04	26	33	2	IPR017884
Domain	EGF_1	LRP4 LRP6 EGF LDLR	1.02e-03	255	33	4	PS00022
Domain	EGF-like_CS	LRP4 LRP6 EGF LDLR	1.11e-03	261	33	4	IPR013032
Domain	CHROMO_2	SUV39H2 CBX8	1.11e-03	28	33	2	PS50013
Domain	CHROMO_1	SUV39H2 CBX8	1.11e-03	28	33	2	PS00598
Domain	SANT	MTA1 MTA3	1.11e-03	28	33	2	PS51293
Domain	EGF_2	LRP4 LRP6 EGF LDLR	1.17e-03	265	33	4	PS01186
Domain	EGF_CA	LRP4 EGF LDLR	1.29e-03	122	33	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP4 EGF LDLR	1.35e-03	124	33	3	IPR001881
Domain	EGF	LRP4 LRP6 EGF	1.41e-03	126	33	3	PF00008
Domain	Chromodomain-like	SUV39H2 CBX8	1.45e-03	32	33	2	IPR016197
Domain	CHROMO	SUV39H2 CBX8	1.54e-03	33	33	2	SM00298
Domain	Chromo/shadow_dom	SUV39H2 CBX8	1.54e-03	33	33	2	IPR000953
Domain	Myb_DNA-binding	MTA1 MTA3	1.74e-03	35	33	2	PF00249
Domain	MYB_LIKE	MTA1 MTA3	2.05e-03	38	33	2	PS50090
Domain	SET	PRDM11 SUV39H2	2.38e-03	41	33	2	PF00856
Domain	Growth_fac_rcpt_	LRP4 EGF LDLR	2.59e-03	156	33	3	IPR009030
Domain	SET	PRDM11 SUV39H2	2.98e-03	46	33	2	SM00317
Domain	SET_dom	PRDM11 SUV39H2	3.52e-03	50	33	2	IPR001214
Domain	SANT	MTA1 MTA3	3.52e-03	50	33	2	SM00717
Domain	SET	PRDM11 SUV39H2	3.52e-03	50	33	2	PS50280
Domain	SANT/Myb	MTA1 MTA3	3.80e-03	52	33	2	IPR001005
Domain	HEAT_REPEAT	PSME4 TEX10	6.78e-03	70	33	2	PS50077
Pathway	REACTOME_PTEN_REGULATION	MTA1 PSME4 MTA3 TRIM27 CBX8	4.83e-06	139	26	5	M27646
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	MTA1 EGF PSME4 MTA3 TRIM27 CBX8	1.81e-05	313	26	6	M27867
Pathway	REACTOME_PTEN_REGULATION	MTA1 PSME4 MTA3 TRIM27	2.92e-05	98	26	4	MM15348
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	MTA1 EGF PSME4 MTA3 TRIM27	8.49e-05	252	26	5	MM15585
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	MTA1 MTA3 CBX8	1.87e-04	61	26	3	M27811
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	LRP4 LRP6	2.94e-04	14	26	2	M47834
Pathway	BIOCARTA_MTA3_PATHWAY	MTA1 MTA3	4.91e-04	18	26	2	M225
Pubmed	The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells.	MTA1 MTA3	8.73e-07	2	33	2	19363681
Pubmed	LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.	LRP6 LDLR	8.73e-07	2	33	2	22128165
Pubmed	Function and regulation of MTA1 and MTA3 in malignancies of the female reproductive system.	MTA1 MTA3	8.73e-07	2	33	2	25319202
Pubmed	Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer.	VEGFC MTA1	8.73e-07	2	33	2	21448429
Pubmed	The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.	LRP6 LDLR	8.73e-07	2	33	2	24506864
Pubmed	Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.	LRP6 LDLR	8.73e-07	2	33	2	26489464
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP4 LRP6 LDLR	1.02e-06	21	33	3	21337463
Pubmed	Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.	LRP6 LDLR	2.62e-06	3	33	2	26034040
Pubmed	Identification and characterization of metastasis-associated gene/protein 1 (MTA1).	MTA1 MTA3	2.62e-06	3	33	2	25315816
Pubmed	Structure, expression and functions of MTA genes.	MTA1 MTA3	2.62e-06	3	33	2	26869315
Pubmed	The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway.	LRP4 LRP6	5.23e-06	4	33	2	20093106
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP4 LRP6	5.23e-06	4	33	2	21471202
Pubmed	A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.	LRP6 LDLR	5.23e-06	4	33	2	29626090
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP4 LRP6	5.23e-06	4	33	2	30325689
Pubmed	MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis.	VEGFC MTA1	5.23e-06	4	33	2	26543080
Pubmed	TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia.	LRP6 LDLR	5.23e-06	4	33	2	30567484
Pubmed	Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility.	MTA1 MTA3	8.72e-06	5	33	2	16502042
Pubmed	Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.	LRP4 LRP6	8.72e-06	5	33	2	16263759
Pubmed	The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.	MTA1 MTA3	8.72e-06	5	33	2	31036553
Pubmed	Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.	LDLR PENK	8.72e-06	5	33	2	1537850
Pubmed	Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.	MTA1 MTA3	8.72e-06	5	33	2	11483358
Pubmed	Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.	LRP4 LRP6	1.31e-05	6	33	2	37091972
Pubmed	RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.	LRP4 LRP6	1.83e-05	7	33	2	34847079
Pubmed	The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.	MTA1 MTA3	2.44e-05	8	33	2	18067919
Pubmed	Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation.	LRP6 LDLR	2.44e-05	8	33	2	15265030
Pubmed	Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.	MTA1 MTA3	3.13e-05	9	33	2	26028330
Pubmed	RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.	MTA1 MTA3	3.13e-05	9	33	2	22926524
Pubmed	PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.	MTA1 MTA3	3.91e-05	10	33	2	34180153
Pubmed	Discovery and refinement of loci associated with lipid levels.	CERS2 LRP4 MOGAT2 LDLR	4.69e-05	211	33	4	24097068
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP4 LRP6	4.78e-05	11	33	2	24639464
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	MTA1 MTA3	5.73e-05	12	33	2	22560079
Pubmed	Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.	MTA1 MTA3	5.73e-05	12	33	2	20720167
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CERS2 ARMT1 TFIP11 MTA1 PSME4 ZFYVE1 LDLR	5.89e-05	1084	33	7	11544199
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CERS2 MACC1 TFIP11 MTA1 MTA3 TEX10 TRIM27 CBX8	6.13e-05	1497	33	8	31527615
Pubmed	LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.	MTA1 MTA3	6.77e-05	13	33	2	19703393
Pubmed	Optimising experimental design for high-throughput phenotyping in mice: a case study.	MTA1 MTA3	6.77e-05	13	33	2	20799038
Pubmed	The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.	MTA1 MTA3	6.77e-05	13	33	2	12920132
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP6 LDLR	7.89e-05	14	33	2	17389516
Pubmed	MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.	MTA1 MTA3	7.89e-05	14	33	2	16428440
Pubmed	NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.	MTA1 MTA3	7.89e-05	14	33	2	25150861
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	MTA1 MTA3	9.10e-05	15	33	2	25247294
Pubmed	NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.	MTA1 MTA3	9.10e-05	15	33	2	19927129
Pubmed	Wnt signaling in the murine diastema.	LRP4 LRP6	1.18e-04	17	33	2	21531785
Pubmed	Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.	MTA1 MTA3	1.32e-04	18	33	2	23201013
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	MTA1 MTA3	1.32e-04	18	33	2	9790534
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	MTA1 MTA3	1.32e-04	18	33	2	10444591
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TFIP11 MTA1 MTA3 TRIM27	1.58e-04	289	33	4	23752268
Pubmed	FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.	MTA1 MTA3	1.64e-04	20	33	2	27773593
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CERS2 TFIP11 PRDM11 MTA1 TRIM27 LDLR CBX8	1.77e-04	1294	33	7	30804502
Pubmed	Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis.	VEGFC EGF	1.81e-04	21	33	2	19710174
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	TEX10 CBX8	1.81e-04	21	33	2	37014752
Pubmed	The transcription factor Maz is essential for normal eye development.	LRP4 LRP6	1.81e-04	21	33	2	32571845
Pubmed	PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.	SUV39H2 CBX8	1.81e-04	21	33	2	18311137
Pubmed	PEG3 binds to H19-ICR as a transcriptional repressor.	PRDM11 MTA3	1.99e-04	22	33	2	27824289
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	MTA1 MTA3 CBX8	3.90e-04	150	33	3	28242625
Pubmed	PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis.	MTA1 MTA3	3.99e-04	31	33	2	29846670
Pubmed	Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.	LRP4 LRP6	4.81e-04	34	33	2	23293290
Pubmed	Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure.	LRP4 LRP6	4.81e-04	34	33	2	26288816
Pubmed	Single-cell transcriptomic analysis of mouse neocortical development.	CCDC80 DNAH12 PENK	5.62e-04	170	33	3	30635555
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	MTA1 MTA3	6.01e-04	38	33	2	33283408
Pubmed	Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.	EGF PENK	7.69e-04	43	33	2	23597562
Pubmed	Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview	SLC35C1 STT3A	8.06e-04	44	33	2	20301507
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	MTA1 MTA3 ZAP70	8.37e-04	195	33	3	19454010
Pubmed	Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background.	LDLR PENK	8.43e-04	45	33	2	29043563
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	MTA1 MTA3	8.43e-04	45	33	2	21258344
Pubmed	Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.	LRP6 LDLR	9.19e-04	47	33	2	18351675
Interaction	SLC16A10 interactions	ARMT1 LDLR EDEM2	2.99e-05	37	33	3	int:SLC16A10
Interaction	MTF2 interactions	MTA1 MTA3 SUV39H2 LDLR	4.01e-05	118	33	4	int:MTF2
Interaction	SH2D4A interactions	TFIP11 TRIM27 SUV39H2 TBC1D9	5.02e-05	125	33	4	int:SH2D4A
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	LRP4 PRDM11 SLC35C1	1.84e-04	153	33	3	chr11p11
Cytoband	Ensembl 112 genes in cytogenetic band chr4q34	VEGFC GALNTL6	8.93e-04	61	33	2	chr4q34
Cytoband	11p11.2	LRP4 SLC35C1	1.64e-03	83	33	2	11p11.2
GeneFamily	Low density lipoprotein receptors	LRP4 LRP6 LDLR	5.83e-07	13	24	3	634
GeneFamily	PHD finger proteins\|NuRD complex	MTA1 MTA3	1.11e-04	12	24	2	1305
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA1 MTA3	1.75e-04	15	24	2	82
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA1 MTA3	2.23e-03	53	24	2	532
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CPB2 PRDM11 MTA1 LDLR	8.29e-06	175	33	4	dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	VEGFC DNAH12 EGF RD3L	9.26e-06	180	33	4	5568063c2518fadb638e665635061ec10d00fb6a
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	VEGFC DNAH12 EGF RD3L	9.26e-06	180	33	4	1be264962fd4ed0bb59f9b8a6956c4239ca32e05
ToppCell	Secretory\|World / shred by cell class for bronchial biopsy	LRP4 CCDC80 MACC1 LDLR	1.27e-05	195	33	4	52f8281fe0df67cec3faa780a23ed6343ed5a6ba
Drug	AC1L71LQ	VEGFC CPB2 MTA1 CBX8 PENK	1.63e-06	139	33	5	CID000327967
Drug	N-(4-hydroxyphenyl)arachidonylamide	CCDC80 CBX8 PENK	8.87e-06	28	33	3	CID000002127
Drug	monatepil	LRP4 LRP6 LDLR	9.88e-06	29	33	3	CID000060810
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	CERS2 LRP4 MOGAT2 LDLR	4.67e-06	103	32	4	EFO_0008595, EFO_0020944
Disease	phospholipids in medium HDL measurement	CERS2 MOGAT2 LDLR	2.93e-05	55	32	3	EFO_0022295
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	LRP4 FAM47E MOGAT2 LDLR	1.85e-04	264	32	4	EFO_0008317, EFO_0020944
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	LRP4 MOGAT2 LDLR	3.06e-04	121	32	3	EFO_0008595, EFO_0020943
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	LRP4 MOGAT2 LDLR	3.53e-04	127	32	3	EFO_0008595, EFO_0020947
Disease	fatty liver disease (implicated_via_orthology)	LRP6 LDLR	5.20e-04	31	32	2	DOID:9452 (implicated_via_orthology)
Disease	hyperthyroidism	PRDM11 TRIM27	6.63e-04	35	32	2	EFO_0009189
Disease	total lipids in small HDL measurement	CERS2 MOGAT2	6.63e-04	35	32	2	EFO_0022311
Disease	macrophage migration inhibitory factor measurement	GALNTL6 CPB2	1.00e-03	43	32	2	EFO_0008221
Disease	Amyotrophic Lateral Sclerosis, Sporadic	LDLR PENK	1.25e-03	48	32	2	C1862941
Disease	Amyotrophic Lateral Sclerosis, Familial	LDLR PENK	1.25e-03	48	32	2	C4551993
Disease	AMYOTROPHIC LATERAL SCLEROSIS 1	LDLR PENK	1.35e-03	50	32	2	C1862939
Disease	total phospholipids in lipoprotein particles measurement	MOGAT2 LDLR	1.52e-03	53	32	2	EFO_0022315
Disease	unipolar depression	VEGFC GALNTL6 PRDM11 MTA3 TRIM27 LDLR	1.67e-03	1206	32	6	EFO_0003761
Disease	free cholesterol in medium HDL measurement	CERS2 MOGAT2	1.81e-03	58	32	2	EFO_0022267
Disease	cholesterol in IDL measurement	MOGAT2 LDLR	1.81e-03	58	32	2	EFO_0021899
Disease	total lipids in medium HDL measurement	CERS2 MOGAT2	1.81e-03	58	32	2	EFO_0022310
Disease	cholesterol in medium HDL measurement	CERS2 MOGAT2	1.88e-03	59	32	2	EFO_0021903
Disease	phospholipids:total lipids ratio	CERS2 MOGAT2 LDLR	1.89e-03	227	32	3	EFO_0020946
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	MOGAT2 LDLR	2.00e-03	61	32	2	EFO_0008317, EFO_0008596, EFO_0020946
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	CERS2 MOGAT2	2.41e-03	67	32	2	EFO_0008595, EFO_0020946
Disease	ovarian cancer (is_marker_for)	VEGFC EGF	2.48e-03	68	32	2	DOID:2394 (is_marker_for)
Disease	cholesteryl ester measurement	CERS2 MOGAT2 LDLR	2.69e-03	257	32	3	EFO_0010351

Protein segments in the cluster

Peptide	Gene	Start	Entry
GADWEEYIKMGKWVY	ARMT1	316	Q9H993
DKPWFYDMKKVWEGY	CERS2	156	Q96G23
KSWYPSPMWSMVIVY	CCDC80	876	Q76M96
EWWMDYQKRYGGFLK	PENK	221	P01210
WYLWVQMYKGTVSMP	EDEM2	296	Q9BV94
DYMYELKNKGRWVHW	DNAH12	1831	Q6ZR08
IVLDPMVGYMYWTDW	LRP6	451	O75581
MVGYMYWTDWGEIPK	LRP6	456	O75581
FMYWTEWGGKPKIDR	LRP6	761	O75581
CWTIWKYMKDYFPIS	MOGAT2	76	Q3SYC2
DKYGPWLEWEIMLQY	PRIM1	286	P49642
AYTWVRGWEMKKTPE	SLC35C1	336	Q96A29
MEYLVKWKGWSQKYS	CBX8	26	Q9HC52
DGYDYSWKKNRMWRK	CPB2	226	Q96IY4
GDRIFYSTWKMKTIW	EGF	256	P01133
VEMMWKPAYDFLYTW	MACC1	781	Q6ZN28
CWLYWKKYGGLKMPT	MTA3	406	Q9BTC8
KWFMAAVAWDVPKYY	GALNTL6	431	Q49A17
NPYKPKWVKMRYGAW	FAM47E	291	Q6ZV65
KWVKMRYGAWYLNPK	FAM47E	296	Q6ZV65
LWYGKEYWALTSPMT	TRIM27	411	P14373
PGEWLRVWYSEDYMK	PRDM11	251	Q9NQV5
TPEDAKVMSWWDYGY	STT3A	516	P46977
WTYWKKYGGLKMPTR	MTA1	421	Q13330
WMKWPKNDSYKPTHY	RD3L	6	P0DJH9
KHWGLYEVLMEKYEW	SRPK3	516	Q9UPE1
PELYALMSDCWIYKW	ZAP70	566	P43403
EYWKMYKCQLRKGGW	VEGFC	76	P49767
MEYYLVKWKGWPDST	SUV39H2	61	Q9H5I1
CSYWKGKVPRQGWMY	TBC1D9	166	Q6ZT07
WKYSAKDWLMSDVDY	TEX10	666	Q9NXF1
KTHWGYYTWPKNMVV	PSME4	1271	Q14997
WMGLAKYAWSGYVIE	ZFYVE1	496	Q9HBF4
YEEITKWYLGWKSMF	TFIP11	676	Q9UBB9
MYWTDWGTPAKIKKG	LDLR	531	P01130
GYMYWTDWGASPKIE	LRP4	871	O75096