Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	deaminase binding	HNRNPCL1 HNRNPCL2	1.15e-04	4	88	2	GO:1990827
GeneOntologyMolecularFunction	G protein activity	GNAQ RAB5A RAB5B RAB5C	1.33e-04	59	88	4	GO:0003925
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	2.85e-04	6	88	2	GO:0034647
GeneOntologyMolecularFunction	hexosyltransferase activity	POGLUT3 GBGT1 C1GALT1 WDFY3 EXTL3 PIGM	3.42e-04	211	88	6	GO:0016758
GeneOntologyCellularComponent	transport vesicle membrane	SLC6A9 ABCA12 PTPRS TMEM30A DBH RAB5A RAB5B RAB5C	3.88e-05	293	90	8	GO:0030658
GeneOntologyCellularComponent	catalytic step 2 spliceosome	HNRNPCL1 CDC40 DHX38 SNRNP200 HNRNPCL2	6.24e-05	97	90	5	GO:0071013
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	SLC6A9 SNX14 SLC29A3 GPR61 MYO1C ABCA12 PTPRS ARHGAP26 SLC44A2 ABCC11 TMEM30A DBH RAB5A RAB5B RAB5C CEMIP	1.32e-04	1307	90	16	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	SLC6A9 SNX14 SLC29A3 GPR61 MYO1C ABCA12 PTPRS ARHGAP26 SLC44A2 ABCC11 TMEM30A DBH RAB5A RAB5B RAB5C CEMIP	1.54e-04	1325	90	16	GO:0012506
GeneOntologyCellularComponent	nucleoplasmic periphery of the nuclear pore complex	HNRNPCL1 HNRNPCL2	2.72e-04	6	90	2	GO:1990826
GeneOntologyCellularComponent	secretory granule membrane	ABCA12 SLC44A2 TMEM30A DBH RAB5A RAB5B RAB5C	5.49e-04	329	90	7	GO:0030667
GeneOntologyCellularComponent	exocytic vesicle membrane	SLC6A9 PTPRS RAB5A RAB5B RAB5C	1.06e-03	179	90	5	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	SLC6A9 PTPRS RAB5A RAB5B RAB5C	1.06e-03	179	90	5	GO:0030672
Domain	PH-BEACH_dom	NBEAL1 WDFY3 WDFY4	5.38e-06	8	87	3	IPR023362
Domain	-	NBEAL1 WDFY3 WDFY4	5.38e-06	8	87	3	2.30.29.40
Domain	PH_BEACH	NBEAL1 WDFY3 WDFY4	5.38e-06	8	87	3	PS51783
Domain	BEACH_dom	NBEAL1 WDFY3 WDFY4	8.04e-06	9	87	3	IPR000409
Domain	BEACH	NBEAL1 WDFY3 WDFY4	8.04e-06	9	87	3	PS50197
Domain	Beach	NBEAL1 WDFY3 WDFY4	8.04e-06	9	87	3	PF02138
Domain	-	NBEAL1 WDFY3 WDFY4	8.04e-06	9	87	3	1.10.1540.10
Domain	Beach	NBEAL1 WDFY3 WDFY4	8.04e-06	9	87	3	SM01026
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	1.28e-04	4	87	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	1.28e-04	4	87	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	2.13e-04	5	87	2	PF02928
Domain	DUF4704	NBEAL1 WDFY3	2.13e-04	5	87	2	IPR031570
Domain	Znf_C5HC2	KDM5C KDM5D	2.13e-04	5	87	2	IPR004198
Domain	DUF4704	NBEAL1 WDFY3	2.13e-04	5	87	2	PF15787
Domain	HECT	UBE3C TRIP12 SMURF2	2.63e-04	27	87	3	PF00632
Domain	HECTc	UBE3C TRIP12 SMURF2	2.63e-04	27	87	3	SM00119
Domain	HECT_dom	UBE3C TRIP12 SMURF2	2.63e-04	27	87	3	IPR000569
Domain	HECT	UBE3C TRIP12 SMURF2	2.63e-04	27	87	3	PS50237
Domain	PH_BEACH	NBEAL1 WDFY3	3.18e-04	6	87	2	PF14844
Domain	hnRNP_C	HNRNPCL1 HNRNPCL2	3.18e-04	6	87	2	IPR017347
Domain	P-loop_NTPase	MAGI2 MYO1C ABCA12 DHX38 WRN ABCC11 GNAQ RAB5A SNRNP200 RAB5B RAB5C DNAH11	5.48e-04	848	87	12	IPR027417
Domain	JmjN	KDM5C KDM5D	9.42e-04	10	87	2	SM00545
Domain	IG_FLMN	FLNA POGLUT3	9.42e-04	10	87	2	SM00557
Domain	JMJN	KDM5C KDM5D	9.42e-04	10	87	2	PS51183
Domain	JmjN	KDM5C KDM5D	9.42e-04	10	87	2	PF02375
Domain	JmjN	KDM5C KDM5D	9.42e-04	10	87	2	IPR003349
Domain	Filamin	FLNA POGLUT3	1.15e-03	11	87	2	PF00630
Domain	FILAMIN_REPEAT	FLNA POGLUT3	1.15e-03	11	87	2	PS50194
Domain	Filamin/ABP280_rpt	FLNA POGLUT3	1.15e-03	11	87	2	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNA POGLUT3	1.15e-03	11	87	2	IPR017868
Domain	WW	MAGI2 ARHGAP39 SMURF2	1.37e-03	47	87	3	PF00397
Domain	OxRdtase_FAD/NAD-bd	CYB5R4 NOS2	1.37e-03	12	87	2	IPR001433
Domain	NAD_binding_1	CYB5R4 NOS2	1.37e-03	12	87	2	PF00175
Domain	Ig_E-set	FLNA POGLUT3 TGM7 SNRNP200	1.42e-03	104	87	4	IPR014756
Domain	WW	MAGI2 ARHGAP39 SMURF2	1.45e-03	48	87	3	SM00456
Domain	WW_DOMAIN_2	MAGI2 ARHGAP39 SMURF2	1.73e-03	51	87	3	PS50020
Domain	WW_DOMAIN_1	MAGI2 ARHGAP39 SMURF2	1.73e-03	51	87	3	PS01159
Domain	WW_dom	MAGI2 ARHGAP39 SMURF2	1.83e-03	52	87	3	IPR001202
Domain	-	KDM5C KDM5D	2.17e-03	15	87	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	2.17e-03	15	87	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	2.17e-03	15	87	2	IPR001606
Domain	ARID	KDM5C KDM5D	2.17e-03	15	87	2	PS51011
Domain	ARID	KDM5C KDM5D	2.17e-03	15	87	2	PF01388
Domain	-	ABCA12 DHX38 WRN ABCC11 GNAQ RAB5A SNRNP200 RAB5B RAB5C DNAH11	2.43e-03	746	87	10	3.40.50.300
Domain	Fd_Rdtase_FAD-bd	CYB5R4 NOS2	3.48e-03	19	87	2	IPR017927
Domain	FAD_FR	CYB5R4 NOS2	3.48e-03	19	87	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	CYB5R4 NOS2	3.48e-03	19	87	2	IPR017938
Domain	AAA+_ATPase	ABCA12 ABCC11 SNRNP200 DNAH11	4.60e-03	144	87	4	IPR003593
Domain	AAA	ABCA12 ABCC11 SNRNP200 DNAH11	4.60e-03	144	87	4	SM00382
Pathway	KEGG_MEDICUS_REFERENCE_EARLY_ENDOSOMAL_FUSION	RAB5A RAB5B RAB5C	7.02e-06	8	72	3	M47778
Pathway	WP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS	RAB5A RAB5B RAB5C	9.87e-05	18	72	3	M39737
Pubmed	Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.	RAB5A RAB5B RAB5C	1.68e-08	3	90	3	22622570
Pubmed	Large-scale profiling of Rab GTPase trafficking networks: the membrome.	RAB5A RAB5B RAB5C	1.67e-07	5	90	3	15944222
Pubmed	A growth factor signaling cascade confined to circular ruffles in macrophages.	RAB5A RAB5B RAB5C	1.67e-07	5	90	3	23213469
Pubmed	A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.	RAB5A RAB5B RAB5C	1.67e-07	5	90	3	11733506
Pubmed	RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.	RAB5A RAB5B RAB5C	3.33e-07	6	90	3	12972505
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	MAGI2 CUL7 MED23 TRIP12 SNRNP200 CEMIP	1.17e-06	130	90	6	12421765
Pubmed	Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).	RAB5A RAB5B RAB5C	1.98e-06	10	90	3	10329441
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF462 FNDC3B FLNA PBRM1 PDGFRB HSD17B12 LANCL1 TMEM30A MED23 CNOT1 SNRNP200 RAB5B RAB5C TPBG	2.54e-06	1203	90	14	29180619
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	FLNA HNRNPCL1 MYO1C WRN TRIP12 SNRNP200 TOP3A RAB5C	2.97e-06	340	90	8	24332808
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	MAGI2 FNDC3B FLNA POGLUT3 PDPR MYO1C PDGFRB HSD17B12 C1GALT1 RAB5A SNRNP200 RAB5B NFU1 RAB5C TPBG	4.54e-06	1451	90	15	30550785
Pubmed	Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing.	CDC40 DHX38	6.62e-06	2	90	2	9524131
Pubmed	The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.	ALB CNOT1	6.62e-06	2	90	2	32238456
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	6.62e-06	2	90	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	6.62e-06	2	90	2	16416087
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	6.62e-06	2	90	2	32081420
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	6.62e-06	2	90	2	9060413
Pubmed	Genetic mapping of the Rab5a and Rab5b genes on mouse Chromosomes 17 and 2, respectively.	RAB5A RAB5B	6.62e-06	2	90	2	8835543
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	6.62e-06	2	90	2	7524912
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	FLNA HSD17B12 UBE3C CNOT1 SNRNP200 RAB5C	1.28e-05	197	90	6	31620119
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNA MYO1C WRN TRIP12 CNOT1 SNRNP200	1.48e-05	202	90	6	33005030
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MAGI2 FLNA HNRNPCL1 MYO1C PTPRS ARHGAP26 ALB GNAQ ARHGAP39 CNOT1 SNRNP200 HNRNPCL2 RAB5C DNAH11	1.81e-05	1431	90	14	37142655
Pubmed	Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors.	RAB5A RAB5B	1.98e-05	3	90	2	19723633
Pubmed	Co-operative regulation of endocytosis by three Rab5 isoforms.	RAB5B RAB5C	1.98e-05	3	90	2	7789520
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	1.98e-05	3	90	2	7544442
Pubmed	Rab5 isoforms orchestrate a "division of labor" in the endocytic network; Rab5C modulates Rac-mediated cell motility.	RAB5A RAB5C	1.98e-05	3	90	2	24587345
Pubmed	Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.	CACNA1B FLNA	1.98e-05	3	90	2	30425165
Pubmed	Direct interaction of EEA1 with Rab5b.	RAB5A RAB5B	1.98e-05	3	90	2	10491193
Pubmed	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.	RAB5A RAB5B RAB5C	2.15e-05	21	90	3	17562788
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PBRM1 CDC40 WRN UBE3C CUL7 MED23 ESPL1 TRIP12 CNOT1 SNRNP200	2.74e-05	759	90	10	35915203
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FLNA PBRM1 CDC40 DHX38 WRN CLN6 HSD17B12 ALB TAF5 TRIP12 RAB5A SNRNP200 RAB5C	3.42e-05	1318	90	13	30463901
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	3.96e-05	4	90	2	16541399
Pubmed	N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.	HNRNPCL1 HNRNPCL2	3.96e-05	4	90	2	36681355
Pubmed	Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.	RAB5B RAB5C	3.96e-05	4	90	2	12493736
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	3.96e-05	4	90	2	17320160
Pubmed	Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.	RAB5A RAB5B	3.96e-05	4	90	2	11703925
Pubmed	Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).	RAB5A RAB5C	3.96e-05	4	90	2	20534488
Pubmed	Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20.	RAB5A RAB5B	3.96e-05	4	90	2	25269936
Pubmed	The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells.	HNRNPCL1 HNRNPCL2	3.96e-05	4	90	2	23831410
Pubmed	hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability.	HNRNPCL1 HNRNPCL2	3.96e-05	4	90	2	10805751
Pubmed	hnRNPC induces isoform shifts in miR-21-5p leading to cancer development.	HNRNPCL1 HNRNPCL2	3.96e-05	4	90	2	35729324
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	3.96e-05	4	90	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	3.96e-05	4	90	2	7951230
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 ATRNL1 DHX38 TTC21B ARHGAP39 CUL7 WDFY4 SNRNP200	4.32e-05	493	90	8	15368895
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MAGI2 FLNA HNRNPCL1 PBRM1 NOS2 FRMD4B HNRNPCL2	4.53e-05	363	90	7	14691545
Pubmed	A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.	FLNA LANCL1 ALB RAB5A RAB5C	5.02e-05	153	90	5	27462432
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	RAB5A RAB5B RAB5C	6.47e-05	30	90	3	16186258
Pubmed	Radiogenomics of clear cell renal cell carcinoma: associations between CT imaging features and mutations.	PBRM1 KDM5C	6.59e-05	5	90	2	24029645
Pubmed	Mutual inhibition of separase and Cdk1 by two-step complex formation.	CKS2 ESPL1	6.59e-05	5	90	2	15989971
Pubmed	Heterogeneous nuclear ribonucleoprotein C1 may control miR-30d levels in endometrial exosomes affecting early embryo implantation.	HNRNPCL1 HNRNPCL2	6.59e-05	5	90	2	29846695
Pubmed	Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene.	HNRNPCL1 HNRNPCL2	6.59e-05	5	90	2	9128719
Pubmed	Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism.	HNRNPCL1 HNRNPCL2	6.59e-05	5	90	2	25809670
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	POGLUT3 MYO1C HSD17B12 TMEM30A ALB NOS2 RAB5A RAB5B NFU1 RAB5C	7.72e-05	859	90	10	31536960
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	FLNA PBRM1 ARHGAP26 ALB TRIP12 SNRNP200	7.78e-05	272	90	6	31010829
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SLC29A3 PDPR PTPRS GNAQ WDFY3 EXTL3 TMEM164 UBE3C RAB5A RAB5B TPBG	9.33e-05	1061	90	11	33845483
Pubmed	Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease.	HNRNPCL1 HNRNPCL2	9.87e-05	6	90	2	26048669
Pubmed	Selective disruption of genes expressed in totipotent embryonal stem cells.	HNRNPCL1 HNRNPCL2	9.87e-05	6	90	2	1317320
Pubmed	The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins.	PDGFRB RAB5A	9.87e-05	6	90	2	15377662
Pubmed	Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.	HNRNPCL1 HNRNPCL2	9.87e-05	6	90	2	15687492
Pubmed	Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis.	HNRNPCL1 HNRNPCL2	9.87e-05	6	90	2	18363099
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF462 HNRNPCL1 CDC40 HSD17B12 LANCL1 ALB ARHGAP39 MED23 TRIP12 CNOT1 SNRNP200	1.11e-04	1082	90	11	38697112
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	FLNA MYO1C SLC44A2 ALB RSU1 RAB5A RAB5B RAB5C	1.11e-04	565	90	8	20458337
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	CYP2C8 PDGFRB PTPRQ RAB5A	1.12e-04	95	90	4	24029230
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	MAGI2 MYO1C ARHGAP26 GDAP1 LANCL1 ARHGAP39 RAB5A	1.30e-04	430	90	7	32581705
Pubmed	The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.	PDGFRB RAB5A	1.38e-04	7	90	2	12783862
Pubmed	Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.	HNRNPCL1 HNRNPCL2	1.38e-04	7	90	2	25846207
Pubmed	Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization.	CACNA1B IL2RA	1.84e-04	8	90	2	11475331
Pubmed	Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.	FLNA MYO1C GDAP1 HSD17B12 TMEM30A UBE3C RAB5A	2.07e-04	464	90	7	32457219
Pubmed	The DNA sequence and analysis of human chromosome 6.	CDC40 NR2E1 IL20RA TMEM30A POPDC3 CUL7 MED23 TPBG	2.14e-04	622	90	8	14574404
Pubmed	Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization.	HNRNPCL1 HNRNPCL2	2.36e-04	9	90	2	10452948
Pubmed	Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.	UBE3C TRIP12	2.36e-04	9	90	2	9575161
Pubmed	Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.	PBRM1 KDM5C	2.36e-04	9	90	2	30355451
Pubmed	MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling.	CKS2 ESPL1	2.36e-04	9	90	2	30674583
Pubmed	Tagging genes with cassette-exchange sites.	ZNF462 ARHGAP26 HSD17B12 TAF5 MED23 TRIP12	2.41e-04	335	90	6	15741177
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYO1C HSD17B12 ABCC11 LANCL1 UBE3C RAB5A RAB5B RAB5C	2.79e-04	647	90	8	26618866
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	FLNA MYO1C ALB	2.83e-04	49	90	3	21362503
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FNDC3B HNRNPCL1 CDC40 DHX38 HSD17B12 LANCL1 TOP3A CEMIP	2.88e-04	650	90	8	38777146
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCA12 ABCC11	2.94e-04	10	90	2	11435397
Pubmed	The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.	RAB5A RAB5B	2.94e-04	10	90	2	26355680
Pubmed	An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.	FLNA SNRNP200	2.94e-04	10	90	2	23500468
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNA PBRM1 MYO1C DHX38 CUL7 TRIP12 CNOT1 SNRNP200	2.97e-04	653	90	8	22586326
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNA PBRM1 MYO1C CDC40 PDGFRB DHX38 HSD17B12 LANCL1 UBE3C MED23 CNOT1 SNRNP200	3.05e-04	1425	90	12	30948266
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	FNDC3B SNX14 PDGFRB SLC44A2 HSD17B12 TMEM30A RAB5C	3.21e-04	499	90	7	22810586
Pubmed	Integral and associated lysosomal membrane proteins.	SLC29A3 SLC44A2 GNAQ RAB5C	3.30e-04	126	90	4	17897319
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	UFSP2 MYO1C HSD17B12 ALB EXTL3 MED23 CEMIP	3.37e-04	503	90	7	36217030
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	SNX14 RAB5A RAB5C	3.38e-04	52	90	3	30655611
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRS PTPRQ	3.59e-04	11	90	2	7832766
Pubmed	A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.	DHX38 SNRNP200	3.59e-04	11	90	2	25849387
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNA PBRM1 ALB TRIP12 SNRNP200	3.65e-04	234	90	5	36243803
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	FLNA PBRM1 LANCL1 ALB SNRNP200	3.72e-04	235	90	5	30258100
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	HNRNPCL1 PDGFRB HSD17B12 ALB SNRNP200	3.79e-04	236	90	5	36339263
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	UFSP2 PTPRS HSD17B12 TMEM30A ALB RAB5A RAB5C	3.93e-04	516	90	7	36610398
Pubmed	Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21).	ALB WDFY3	4.30e-04	12	90	2	15271968
Pubmed	Interaction between nucleosome assembly protein 1-like family members.	HNRNPCL1 HNRNPCL2	4.30e-04	12	90	2	21333655
Pubmed	Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.	WDFY3 RAB5A	4.30e-04	12	90	2	32037591
Pubmed	The biogenesis of the coiled body during early mouse development.	HNRNPCL1 HNRNPCL2	4.30e-04	12	90	2	7768196
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDPR KDM5C ARHGAP26 MED23 ESPL1 CNOT1 FRMD4B	4.56e-04	529	90	7	14621295
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	5.07e-04	13	90	2	14660691
Pubmed	ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells.	PTPRQ RAB5A	5.07e-04	13	90	2	29222402
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5C KDM5D	5.07e-04	13	90	2	24619213
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	FLNA UFSP2 MYO1C GDAP1 WRN HSD17B12 TMEM164 CSMD1 ESPL1 SMURF2 RAB5C	5.09e-04	1293	90	11	15342556
Cytoband	6q21	CDC40 NR2E1 POPDC3 NMBR	4.00e-05	96	90	4	6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr6q14	SNX14 TMEM30A CYB5R4 TPBG	4.16e-05	97	90	4	chr6q14
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 WDFY3 WDFY4	2.88e-06	9	60	3	1230
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	1.11e-03	15	60	2	418
GeneFamily	RAB, member RAS oncogene GTPases	RAB5A RAB5B RAB5C	1.31e-03	65	60	3	388
GeneFamily	WD repeat domain containing	CDC40 NBEAL1 WDFY3 TAF5 WDFY4	1.75e-03	262	60	5	362
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRS PTPRQ	2.18e-03	21	60	2	813
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	2.85e-03	24	60	2	485
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNG7	3.34e-03	26	60	2	253
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_-_proliferative\|E16.5-samps / Age Group, Lineage, Cell class and subclass	RHCG CKS2 CACNG7 FXYD6 IL20RA POPDC3	3.45e-07	136	90	6	96370f0e3abf1c9ec7a91595b5d0f97ac2ab4b78
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	WRN UBE3C CUL7 MED23 WDFY4 CEMIP	1.67e-06	178	90	6	536a601abcc60867949ea06e9aafb6c7b799b56b
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	5.26e-05	4	88	2	DOID:0060809 (implicated_via_orthology)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 WDFY4	5.26e-05	4	88	2	DOID:2935 (implicated_via_orthology)
Disease	Kidney Diseases	CYP2C8 TTC21B ALB NOS2	1.42e-04	88	88	4	C0022658
Disease	Hantavirus hemorrhagic fever with renal syndrome (is_marker_for)	ALB IL2RA	2.43e-04	8	88	2	DOID:11266 (is_marker_for)
Disease	Hepatic Insufficiency	ALB NOS2	3.12e-04	9	88	2	C1306571
Disease	colorectal health	MAGI2 FNDC3B GNAQ CSMD1 ESPL1	3.46e-04	201	88	5	EFO_0008460
Disease	severe acute respiratory syndrome, COVID-19	MAGI2 GDAP1 WRN GNAQ NMBR CSMD1 WDFY4	3.86e-04	447	88	7	EFO_0000694, MONDO_0100096
Disease	multiple sclerosis	ARHGAP26 SLC44A2 IL20RA POPDC3 C1GALT1 CSMD1 IL2RA TOP3A	4.03e-04	594	88	8	MONDO_0005301
Disease	trimethyllysine measurement	IL20RA GNAQ	4.75e-04	11	88	2	EFO_0009134
Disease	Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement	RAB5B DNAH11	4.75e-04	11	88	2	EFO_0009923
Disease	Hepatomegaly	SLC29A3 ALB NOS2	5.70e-04	54	88	3	C0019209
Disease	Global developmental delay	ZNF462 CACNA1B KDM5C CNOT1	6.86e-04	133	88	4	C0557874
Disease	blood osmolality measurement	ABCA12 CYB5R4 CEMIP	7.02e-04	58	88	3	EFO_0007967
Disease	carcinoma (implicated_via_orthology)	RAB5A RAB5B RAB5C	9.36e-04	64	88	3	DOID:305 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	1.03e-03	16	88	2	DOID:0050888 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	PDGFRB KDM5C WDFY3 KDM5D	1.13e-03	152	88	4	DOID:0060041 (implicated_via_orthology)
Disease	Paroxysmal atrial fibrillation	ZNF462 MYO1C ZPBP2 FRMD4B	1.24e-03	156	88	4	C0235480
Disease	familial atrial fibrillation	ZNF462 MYO1C ZPBP2 FRMD4B	1.24e-03	156	88	4	C3468561
Disease	Persistent atrial fibrillation	ZNF462 MYO1C ZPBP2 FRMD4B	1.24e-03	156	88	4	C2585653
Disease	Schizophrenia	CACNA1B MAGI2 SLC6A9 PBRM1 PDGFRB NR2E1 FXYD6 CSMD1 IL2RA	1.28e-03	883	88	9	C0036341
Disease	cortical thickness change measurement	CSMD1 FRMD4B	1.30e-03	18	88	2	EFO_0021501
Disease	Atrial Fibrillation	ZNF462 MYO1C ZPBP2 FRMD4B	1.36e-03	160	88	4	C0004238
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	ARHGAP26 IL2RA WDFY4 RAB5B	1.70e-03	170	88	4	EFO_0000685, EFO_0007791, EFO_0007837
Disease	autoimmune disease	ZPBP2 IL2RA RAB5B RAB5C	1.81e-03	173	88	4	EFO_0005140
Disease	age at menarche	ZNF462 MAGI2 FNDC3B ATRNL1 HSD17B12 GNAQ CSMD1	2.01e-03	594	88	7	EFO_0004703
Disease	arginine measurement	CSMD1 MED23	2.14e-03	23	88	2	EFO_0020990
Disease	Liver Cirrhosis, Experimental	FLNA CROT MYO1C PDGFRB SLC44A2 FXYD6 ALB NOS2	2.20e-03	774	88	8	C0023893
Disease	Intellectual Disability	ZNF462 CACNA1B SNX14 PDGFRB KDM5C MED23	2.23e-03	447	88	6	C3714756
Disease	Intrahepatic Cholangiocarcinoma	PBRM1 NOS2	2.33e-03	24	88	2	C0345905
Disease	airway responsiveness measurement	CSMD1 WDFY4	2.33e-03	24	88	2	EFO_0006897
Disease	tobacco smoke exposure measurement	HSD17B12 DBH	2.33e-03	24	88	2	EFO_0009115
Disease	Extrahepatic Cholangiocarcinoma	PBRM1 NOS2	2.33e-03	24	88	2	C3805278
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	CYP2C8 PDGFRB ATRNL1	2.34e-03	88	88	3	EFO_0803332
Disease	sleep duration, low density lipoprotein cholesterol measurement	MAGI2 DHX38 SLC44A2	2.58e-03	91	88	3	EFO_0004611, EFO_0005271
Disease	Cholangiocarcinoma	PBRM1 NOS2	2.73e-03	26	88	2	C0206698
Disease	alcohol use disorder (implicated_via_orthology)	PBRM1 KDM5C DBH KDM5D	2.80e-03	195	88	4	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPVFRFYHAYGTLME	TTC21B	36	Q7Z4L5
LGMFLYEYARRHPDY	ALB	351	P02768
FNMEPSYDFLHIYEG	CSMD1	1496	Q96PZ7
YDAARHGIIMYSHPY	ABCA12	1956	Q86UK0
TVYFGMNPIVVFHGY	CYP2C8	66	P10632
LDYAGYHQYIEEMLP	DNAH11	4186	Q96DT5
TMPSEDYYAYHFVPF	ADPRM	141	Q3LIE5
HDIAYLLIYMDYPRY	ADAM32	271	Q8TC27
EMDPFHYDYQTLRIG	FXYD6	26	Q9H0Q3
PGYRMELSIFYVVYF	CACNA1B	1386	Q00975
MDKVEQSYPGRSHYY	CEMIP	1116	Q8WUJ3
VPYMKQYEAHTFYDG	NBEAL1	1691	Q6ZS30
TAGQERYHSLAPMYY	RAB5A	76	P20339
TAGQERYHSLAPMYY	RAB5B	76	P61020
ERYHSLAPMYYRGAQ	RAB5C	81	P51148
FHSYLEGYIYRHMDP	ARHGAP39	821	Q9C0H5
EKIMYSHLVDYFPEY	GNAQ	281	P50148
SVSLYYGPLLFMYVH	OR5H8	246	P0DN80
FHQEMLNYVLSPFYY	NOS2	476	P35228
QRDYYDGMYSFPARV	HNRNPCL1	116	O60812
SMYHVGDYVYVEPAE	PBRM1	956	Q86U86
PNHILYMYRSFNYNE	NMBR	281	P28336
INVERYYYVVHPMRY	GPR61	136	Q9BZJ8
VMVNGRHNYETYLEY	MAGI2	536	Q86UL8
QRDYYDGMYSFPARV	HNRNPCL2	116	B2RXH8
HAPNEMLYGRIGYIY	LANCL1	146	O43813
AFYHPVRYMFIQTQD	NFU1	51	Q9UMS0
HYERIIYPYEMFQSG	KDM5D	156	Q9BY66
TYSVYQHDFCGPYMI	OR5A2	161	Q8NGI9
GFMLYIPIEYALHVY	PDPR	676	Q8NCN5
YYMSPERIHENGYNF	NEK7	201	Q8TDX7
HYYQHYMADRLLGVV	CUL7	1266	Q14999
PDKESMYYPRVQHYR	GDAP1	111	Q8TB36
PVTYLYNTLHYYEMH	MED23	1001	Q9ULK4
RVYHHYIQAAGGYMV	ABCC11	791	Q96J66
FSVMGYSIYRYIHVG	IL20RA	266	Q9UHF4
YPNGKITHYTIYAME	PTPRQ	636	Q9UMZ3
LIRGYRVYYTMEPEH	PTPRS	456	Q13332
HLYLLVATYTEGMYP	PFN4	96	Q8NHR9
MKIVEALPTYGVHYY	FRMD4B	246	Q9Y2L6
MYFQGLHLYTVVVYD	ESPL1	396	Q14674
FMRGYRVHYYIFTDN	GBGT1	136	Q8N5D6
MYKVEYTPYEEGLHS	FLNA	1316	P21333
RPATDYHVRVYAMYN	FNDC3B	346	Q53EP0
VYGYMPLLYTQFRVD	EXTL3	886	O43909
FGILEEMCVNYVHYY	DBH	481	P09172
VNNVGMSYEYPEYFL	HSD17B12	131	Q53GQ0
HMYVYDGDSIYAPLI	ATRNL1	146	Q5VV63
MNRPSSSEQYFHYRY	CACNG7	161	P62955
TYNYPVHYFDGRKRM	TMEM30A	296	Q9NV96
TERIYHFVVGQMVYY	IL2RA	136	P01589
VLGYGIFHCYMEYSR	SLC44A2	271	Q8IWA5
MYELEYLVYHLRPYG	C1GALT1	316	Q9NS00
YHYDIRLPNFYQMST	POPDC3	256	Q9HBV1
YPHEVNGTPMYLYEV	NR2E1	166	Q9Y466
VPMVHNGYGFFYHIR	CROT	556	Q9UKG9
GHEYIYVDPMQLPYD	PDGFRB	576	P09619
TYKYLYGRHMQANPE	RSU1	241	Q15404
PTMYEEYYSGLKHFI	TAF5	211	Q15542
YPLFVHMYLELVYNQ	TAF5	241	Q15542
YARYYMRPVLAAHVF	SLC29A3	256	Q9BZD2
MYDYQGRSYLHIPQD	CDC40	246	O60508
YTMEGYLYVQEKRHF	ARHGAP26	266	Q9UNA1
VIHYGAPKDMESYYQ	WRN	836	Q14191
LPHFFMGYYRYSKET	SLCO1B7	66	G3V0H7
RGFVYNVSPYMEYHP	CYB5R4	76	Q7L1T6
VGDYFHMAYNVITPF	CLN6	81	Q9NWW5
KYFDEHYEYRHVMLP	CKS2	11	P33552
FMQFPHHLQEYIEYG	CNOT1	981	A5YKK6
VQGIYGYHHYMQDRI	UFSP2	281	Q9NUQ7
SHEMLNPYYGLFQYS	SMURF2	446	Q9HAU4
LVLKQDSPYYEHFYM	POGLUT3	391	Q7Z4H8
EYPVTLMQFFRYLYH	WDFY3	1866	Q8IZQ1
RNDMFYNHYPYVPET	WDFY3	2386	Q8IZQ1
YDYLMYVGRVVFQVP	SNX14	791	Q9Y5W7
PFELEIYYIQHVMLY	TMEM164	171	Q5U3C3
DAVNIFHPYFYGDRM	WDFY4	2771	Q6ZS81
AIMYIYGHRNYFQDI	SLC6A9	546	P48067
GYTPDYIVYHELVMT	DHX38	1111	Q92620
LHYRGEMQQYFTYHT	ERVH48-1	51	M5A8F1
MILARNYLDVYPYDH	TOP3A	471	Q13472
FYYRYPSFQDVHVMV	RHCG	56	Q9UBD6
YVDYPIYDVLQMVGH	SNRNP200	1676	O75643
YQRRHPEHYVDYTYM	ZNF462	1331	Q96JM2
MEGYHYRYEINADPR	TPBG	396	Q13641
YIMRDYGFVYKGHER	TGM7	161	Q96PF1
FYIGEHLLPYNMTVY	TRIP12	1346	Q14669
DIRHNFSPYFYMLYL	PIGM	266	Q9H3S5
AYREPDYSYQMAVRF	ZPBP2	136	Q6X784
EQILHYMIHNGYYRS	UBE3C	196	Q15386
HYERIVYPYEMYQSG	KDM5C	156	P41229
YSRQHMERYRGVSFY	MYO1C	96	O00159