Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1C CATSPER1 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

7.42e-09129919GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1C CATSPER1 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

2.94e-08151919GO:0015085
GeneOntologyMolecularFunctioncytoskeletal protein binding

CACNA1C BIN1 LIMA1 DLC1 ANK1 BRCA2 IQGAP2 TRPM7 CENPF TTLL6 ARHGEF7 SYNE1 SPTAN1 SYNE2 CAPN3 ITPRID2 DAAM1 ACE

1.93e-0610999118GO:0008092
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

3.68e-063439110GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

4.55e-054599110GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

5.08e-054659110GO:0046873
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CATSPER1 CACHD1 RYR1

5.69e-0546914GO:0005245
GeneOntologyMolecularFunctionactin binding

BIN1 LIMA1 IQGAP2 TRPM7 SYNE1 SPTAN1 SYNE2 ITPRID2 DAAM1 ACE

6.50e-054799110GO:0003779
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2 ITPR2

7.11e-0518913GO:0015278
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

1.23e-044912GO:0005219
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

1.30e-046279111GO:0022890
GeneOntologyMolecularFunctionchannel activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

1.38e-045259110GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ITPR2

1.40e-045269110GO:0022803
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

2.04e-045912GO:0140444
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

2.14e-046649111GO:0008324
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

3.04e-046912GO:0048763
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR2 ITPR2

3.75e-0431913GO:0099604
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

CATSPER1 KCNT2 RYR1 RYR2 ITPR2

4.52e-04140915GO:0099094
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR2 ITPR2

4.52e-0433913GO:0005217
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 3'-phosphomonoesters

RNASE3 TSEN34

5.65e-048912GO:0016892
GeneOntologyMolecularFunctionactin filament binding

BIN1 LIMA1 IQGAP2 SYNE1 SPTAN1 ITPRID2

6.02e-04227916GO:0051015
GeneOntologyMolecularFunctioncalmodulin binding

CACNA1C IQGAP2 SPTAN1 ACE RYR1 RYR2

6.45e-04230916GO:0005516
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

6.54e-047589111GO:0015318
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C CATSPER1 KCNT2 CACHD1 RYR1

6.57e-04152915GO:0022843
GeneOntologyMolecularFunctiongated channel activity

CACNA1C CATSPER1 KCNT2 CACHD1 RYR1 RYR2 ITPR2

8.37e-04334917GO:0022836
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1C CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

9.47e-047939111GO:0015075
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1C CATSPER1 KCNT2 CACHD1 RYR1

1.47e-03182915GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1C CATSPER1 KCNT2 CACHD1 RYR1

1.54e-03184915GO:0022832
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC4 ITPR2

1.80e-0314912GO:0070679
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

CATSPER1 KCNT2 RYR1 RYR2 ITPR2

1.90e-03193915GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

CATSPER1 KCNT2 RYR1 RYR2 ITPR2

2.08e-03197915GO:0022834
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

RNASE3 TSEN34

3.70e-0320912GO:0016894
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNA1C BIN1 CATSPER1 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 RYR1 RYR2 ITPR2

1.23e-063929111GO:0070588
GeneOntologyBiologicalProcesscalcium ion transport

CACNA1C BIN1 CATSPER1 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 ACE RYR1 RYR2 ITPR2

2.41e-065099112GO:0006816
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell action potential

CACNA1C BIN1 RYR2

1.78e-0512913GO:0098911
GeneOntologyBiologicalProcesscell cycle checkpoint signaling

KNTC1 BRCA2 CENPF TIPIN BUB1 ETAA1 KNL1

4.96e-05217917GO:0000075
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1C BIN1 CATSPER1 ANK1 KCNT2 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

4.98e-059229114GO:0098662
GeneOntologyBiologicalProcesshomologous chromosome orientation in meiotic metaphase I

BRCA2 KNL1

5.76e-053912GO:0031619
GeneOntologyBiologicalProcessmitotic spindle assembly checkpoint signaling

KNTC1 CENPF BUB1 KNL1

7.56e-0551914GO:0007094
GeneOntologyBiologicalProcessspindle assembly checkpoint signaling

KNTC1 CENPF BUB1 KNL1

7.56e-0551914GO:0071173
GeneOntologyBiologicalProcessreplication fork processing

BRCA2 TIPIN ETAA1 BOD1L1

8.16e-0552914GO:0031297
GeneOntologyBiologicalProcessmitotic cell cycle checkpoint signaling

KNTC1 CENPF TIPIN BUB1 ETAA1 KNL1

8.51e-05163916GO:0007093
GeneOntologyBiologicalProcessnegative regulation of mitotic metaphase/anaphase transition

KNTC1 CENPF BUB1 KNL1

8.80e-0553914GO:0045841
GeneOntologyBiologicalProcessnegative regulation of mitotic sister chromatid segregation

KNTC1 CENPF BUB1 KNL1

8.80e-0553914GO:0033048
GeneOntologyBiologicalProcessnegative regulation of sister chromatid segregation

KNTC1 CENPF BUB1 KNL1

8.80e-0553914GO:0033046
GeneOntologyBiologicalProcessnegative regulation of mitotic sister chromatid separation

KNTC1 CENPF BUB1 KNL1

8.80e-0553914GO:2000816
GeneOntologyBiologicalProcessmitotic spindle checkpoint signaling

KNTC1 CENPF BUB1 KNL1

8.80e-0553914GO:0071174
GeneOntologyBiologicalProcessnegative regulation of organelle organization

KNTC1 PATL2 LIMA1 DLC1 CENPF ARHGEF7 SPTAN1 BUB1 KNL1

1.01e-04421919GO:0010639
GeneOntologyBiologicalProcessnegative regulation of metaphase/anaphase transition of cell cycle

KNTC1 CENPF BUB1 KNL1

1.02e-0455914GO:1902100
GeneOntologyBiologicalProcessnegative regulation of chromosome separation

KNTC1 CENPF BUB1 KNL1

1.02e-0455914GO:1905819
GeneOntologyBiologicalProcessnegative regulation of cellular component organization

XYLT1 KNTC1 PATL2 LIMA1 DLC1 CENPF ARHGEF7 SPTAN1 BUB1 DAB2 PFDN4 ACE KNL1

1.04e-048649113GO:0051129
GeneOntologyBiologicalProcessspindle checkpoint signaling

KNTC1 CENPF BUB1 KNL1

1.17e-0457914GO:0031577
GeneOntologyBiologicalProcessnegative regulation of chromosome segregation

KNTC1 CENPF BUB1 KNL1

1.17e-0457914GO:0051985
GeneOntologyBiologicalProcessDNA-templated DNA replication

BRCA2 TIPIN ERVK-8 ETAA1 BOD1L1 RFC3

1.38e-04178916GO:0006261
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

CACNA1C BIN1 CATSPER1 ANK1 KCNT2 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

1.41e-0410179114GO:0098660
GeneOntologyBiologicalProcessDNA-templated DNA replication maintenance of fidelity

BRCA2 TIPIN ETAA1 BOD1L1

1.43e-0460914GO:0045005
GeneOntologyBiologicalProcessregulation of mitotic sister chromatid segregation

KNTC1 CENPF BUB1 KNL1

1.43e-0460914GO:0033047
GeneOntologyBiologicalProcessnegative regulation of mitotic nuclear division

KNTC1 CENPF BUB1 KNL1

1.84e-0464914GO:0045839
GeneOntologyBiologicalProcessregulation of mitotic sister chromatid separation

KNTC1 CENPF BUB1 KNL1

1.84e-0464914GO:0010965
GeneOntologyBiologicalProcessmeiotic metaphase I homologous chromosome alignment

BRCA2 KNL1

1.91e-045912GO:0043060
GeneOntologyBiologicalProcessmitotic sister chromatid separation

KNTC1 CENPF BUB1 KNL1

2.20e-0467914GO:0051306
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1C BIN1 CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

2.44e-049429113GO:0098655
GeneOntologyBiologicalProcessmeiotic metaphase chromosome alignment

BRCA2 KNL1

2.85e-046912GO:0051311
GeneOntologyBiologicalProcessnegative regulation of nuclear division

KNTC1 CENPF BUB1 KNL1

3.06e-0473914GO:0051784
GeneOntologyBiologicalProcessregulation of cardiac muscle cell action potential

CACNA1C BIN1 RYR2

3.09e-0430913GO:0098901
GeneOntologyBiologicalProcessregulation of chromosome segregation

KNTC1 CENPF BUB1 SMC6 KNL1

3.78e-04139915GO:0051983
GeneOntologyBiologicalProcessregulation of chromosome separation

KNTC1 CENPF BUB1 KNL1

4.14e-0479914GO:1905818
GeneOntologyBiologicalProcessinorganic ion homeostasis

CACNA1C ANK1 TRPM7 TRPC4 CAPN3 PDZD8 RYR1 RYR2 ATP6V0A2 ITPR2

4.14e-046229110GO:0098771
GeneOntologyBiologicalProcessmetal ion transport

CACNA1C BIN1 CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 ACE RYR1 RYR2 ITPR2

4.33e-0410009113GO:0030001
GeneOntologyBiologicalProcessnegative regulation of cell cycle phase transition

KNTC1 BRCA2 CENPF TIPIN BUB1 ETAA1 KNL1

4.54e-04311917GO:1901988
GeneOntologyBiologicalProcessregulation of action potential

CACNA1C BIN1 TRPC4 RYR2

4.55e-0481914GO:0098900
GeneOntologyBiologicalProcessDNA replication

BRCA2 TIPIN ERVK-8 ETAA1 BOD1L1 RFC3 POLK

4.63e-04312917GO:0006260
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

CACNA1C CAPN3 RYR1 RYR2 ITPR2

4.73e-04146915GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

CACNA1C CAPN3 RYR1 RYR2 ITPR2

4.88e-04147915GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

CACNA1C CAPN3 RYR1 RYR2 ITPR2

5.19e-04149915GO:0051282
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1C BIN1 CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 ACE RYR1 RYR2 ATP6V0A2 ITPR2

5.26e-0411579114GO:0006812
GeneOntologyBiologicalProcessregulation of calcium ion transport

CACNA1C BIN1 CATSPER1 TRPC4 CAPN3 ACE RYR2

5.69e-04323917GO:0051924
GeneOntologyBiologicalProcessventricular cardiac muscle cell action potential

CACNA1C BIN1 RYR2

5.79e-0437913GO:0086005
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

CACNA1C RYR1 RYR2

5.79e-0437913GO:0014808
GeneOntologyBiologicalProcesssequestering of calcium ion

CACNA1C CAPN3 RYR1 RYR2 ITPR2

5.86e-04153915GO:0051208
GeneOntologyBiologicalProcesschromosome separation

KNTC1 CENPF BUB1 KNL1

6.23e-0488914GO:0051304
GeneOntologyBiologicalProcessactin filament-based process

CACNA1C BIN1 LIMA1 DLC1 IQGAP2 TRPM7 ARHGEF7 SPTAN1 SYNE2 CAPN3 DAAM1 RYR2

6.58e-049129112GO:0030029
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

CACNA1C RYR1 RYR2

6.77e-0439913GO:1903514
GeneOntologyBiologicalProcessregulation of cilium beat frequency involved in ciliary motility

CATSPER1 TTLL6

6.79e-049912GO:0060296
GeneOntologyBiologicalProcessregulation of organelle organization

KNTC1 PATL2 BIN1 LIMA1 DLC1 ANK1 IQGAP2 CENPF ARHGEF7 SYNE1 SPTAN1 SYNE2 BUB1 SMC6 KNL1

7.46e-0413429115GO:0033043
GeneOntologyBiologicalProcessregulation of heart rate by cardiac conduction

CACNA1C BIN1 ACE

7.84e-0441913GO:0086091
GeneOntologyBiologicalProcessregulation of mitotic metaphase/anaphase transition

KNTC1 CENPF BUB1 KNL1

8.31e-0495914GO:0030071
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

CACNA1C BIN1 RYR2

9.02e-0443913GO:0086004
GeneOntologyBiologicalProcesshematopoietic stem cell proliferation

BRCA2 DAB2 ACE

9.02e-0443913GO:0071425
GeneOntologyBiologicalProcessregulation of metaphase/anaphase transition of cell cycle

KNTC1 CENPF BUB1 KNL1

9.33e-0498914GO:1902099
GeneOntologyBiologicalProcessnucleus localization

BIN1 SYNE1 SYNE2

9.65e-0444913GO:0051647
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

CACNA1C RYR1 RYR2

9.65e-0444913GO:0070296
GeneOntologyBiologicalProcessmetaphase/anaphase transition of mitotic cell cycle

KNTC1 CENPF BUB1 KNL1

1.01e-03100914GO:0007091
GeneOntologyBiologicalProcesscardiac conduction

CACNA1C BIN1 ACE RYR2

1.01e-03100914GO:0061337
GeneOntologyBiologicalProcessmaintenance of location in cell

CACNA1C SYNE1 CAPN3 RYR1 RYR2 ITPR2

1.01e-03259916GO:0051651
GeneOntologyBiologicalProcessnegative regulation of cell cycle

KNTC1 BRCA2 CENPF TIPIN BUB1 ETAA1 CDK5RAP1 KNL1

1.03e-03464918GO:0045786
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR2

1.03e-0311912GO:0071313
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CACNA1C TRPC4 CAPN3 PDZD8 RYR1 RYR2 ITPR2

1.06e-03359917GO:0006874
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CACNA1C ANK1 TRPM7 TRPC4 CAPN3 PDZD8 RYR1 RYR2 ATP6V0A2 ITPR2

1.08e-037059110GO:0055080
GeneOntologyBiologicalProcessnegative regulation of cell cycle process

KNTC1 BRCA2 CENPF TIPIN BUB1 ETAA1 KNL1

1.11e-03362917GO:0010948
GeneOntologyBiologicalProcessmetaphase/anaphase transition of cell cycle

KNTC1 CENPF BUB1 KNL1

1.12e-03103914GO:0044784
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CACNA1C BIN1 CATSPER1 KCNT2 TRPM3 TRPM7 TRPC4 CAPN3 CACHD1 RYR1 RYR2 ATP6V0A2 ITPR2

1.19e-0311159113GO:0034220
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CACNA1C ANK1 TRPM7 TRPC4 CAPN3 PDZD8 RYR1 RYR2 ATP6V0A2 ITPR2

1.23e-037179110GO:0050801
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

CACNA1C RYR2

1.23e-0312912GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

CACNA1C RYR2

1.23e-0312912GO:0086016
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-8 RFC3 POLK

1.24e-0348913GO:0000731
GeneOntologyBiologicalProcessmetaphase chromosome alignment

KNTC1 BRCA2 CENPF KNL1

1.29e-03107914GO:0051310
GeneOntologyBiologicalProcessnegative regulation of chromosome organization

KNTC1 CENPF BUB1 KNL1

1.29e-03107914GO:2001251
GeneOntologyBiologicalProcessregulation of sister chromatid segregation

KNTC1 CENPF BUB1 KNL1

1.48e-03111914GO:0033045
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

CACNA1C TRPM7 TRPC4 CAPN3 PDZD8 RYR1 RYR2 ATP6V0A2 ITPR2

1.50e-03611919GO:0030003
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle

KNTC1 CENPF TIPIN BUB1 ETAA1 KNL1

1.56e-03282916GO:0045930
GeneOntologyBiologicalProcessregulation of cell cycle checkpoint

BRCA2 ETAA1 KNL1

1.57e-0352913GO:1901976
GeneOntologyBiologicalProcessregulation of actin filament-based movement

CACNA1C BIN1 RYR2

1.66e-0353913GO:1903115
GeneOntologyBiologicalProcesscalcium ion homeostasis

CACNA1C TRPC4 CAPN3 PDZD8 RYR1 RYR2 ITPR2

1.67e-03389917GO:0055074
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR2

1.69e-0314912GO:0071415
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

CACNA1C TRPM7 TRPC4 CAPN3 PDZD8 RYR1 RYR2 ATP6V0A2 ITPR2

1.69e-03622919GO:0006873
GeneOntologyBiologicalProcesspositive regulation of transcription elongation by RNA polymerase II

DAB2 MED23 MED17

1.75e-0354913GO:0032968
GeneOntologyBiologicalProcessnegative regulation of supramolecular fiber organization

LIMA1 DLC1 ARHGEF7 SPTAN1 PFDN4

1.81e-03197915GO:1902904
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

CACNA1C RYR2

1.95e-0315912GO:0086067
GeneOntologyBiologicalProcesstelomere maintenance via recombination

BRCA2 SMC6

1.95e-0315912GO:0000722
GeneOntologyBiologicalProcessestablishment of chromosome localization

KNTC1 BRCA2 CENPF KNL1

2.09e-03122914GO:0051303
GeneOntologyCellularComponentZ disc

CACNA1C BIN1 ANK1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

3.43e-07151928GO:0030018
GeneOntologyCellularComponentI band

CACNA1C BIN1 ANK1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

7.06e-07166928GO:0031674
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CATSPER1 TRPC4 CACHD1 RYR1 RYR2

8.27e-0773926GO:0034704
GeneOntologyCellularComponentsarcomere

CACNA1C BIN1 ANK1 SYNE1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

1.54e-06249929GO:0030017
GeneOntologyCellularComponentmyofibril

CACNA1C BIN1 ANK1 SYNE1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

3.27e-06273929GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

CACNA1C BIN1 ANK1 SYNE1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

5.34e-06290929GO:0043292
GeneOntologyCellularComponentcell cortex

DLC1 ANK1 IQGAP2 ARHGEF7 SPTAN1 TRPC4 CTNND1 RYR1 ITPR2

3.77e-05371929GO:0005938
GeneOntologyCellularComponentsarcoplasmic reticulum

ANK1 SYNE2 RYR1 RYR2 ITPR2

4.35e-0588925GO:0016529
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

SYNE2 RYR1 RYR2 ITPR2

4.56e-0545924GO:0033017
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CATSPER1 CACHD1 RYR1

4.98e-0546924GO:0005891
GeneOntologyCellularComponentmembrane protein complex

CACNA1C SYNRG CATSPER1 ANK1 NDUFAF1 TRA SYNE1 TRPC4 SYNE2 DAB2 CACHD1 CTNND1 GABBR2 TRAV38-2DV8 TRAV38-1 RYR1 RYR2 ATP6V0A2

8.05e-0514989218GO:0098796
GeneOntologyCellularComponentcaveola

CACNA1C BMPR2 DLC1 TRPC4 CTNND1

1.31e-04111925GO:0005901
GeneOntologyCellularComponentsarcoplasm

ANK1 SYNE2 RYR1 RYR2 ITPR2

1.49e-04114925GO:0016528
GeneOntologyCellularComponentouter kinetochore

CENPF BUB1 KNL1

1.56e-0424923GO:0000940
GeneOntologyCellularComponentsarcolemma

CACNA1C BIN1 ANK1 CAPN3 RYR1 RYR2

1.94e-04190926GO:0042383
GeneOntologyCellularComponentT-tubule

CACNA1C BIN1 CAPN3 RYR1

4.10e-0479924GO:0030315
GeneOntologyCellularComponentplasma membrane raft

CACNA1C BMPR2 DLC1 TRPC4 CTNND1

4.83e-04147925GO:0044853
GeneOntologyCellularComponentcation channel complex

CACNA1C CATSPER1 TRPC4 CACHD1 RYR1 RYR2

6.03e-04235926GO:0034703
GeneOntologyCellularComponentmain axon

BIN1 ANK1 TRPM7 SPTAN1

6.45e-0489924GO:0044304
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

8.43e-0410922GO:0014701
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

1.03e-0311922GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.03e-0311922GO:0034993
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

1.03e-0311922GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.03e-0311922GO:0106094
GeneOntologyCellularComponentcell leading edge

LIMA1 DLC1 ANK1 IQGAP2 TRPM7 ARHGEF7 SYNE2 CTNND1

1.63e-03500928GO:0031252
GeneOntologyCellularComponentsupramolecular fiber

KNTC1 CACNA1C BIN1 DLC1 ANK1 IQGAP2 TTLL6 SYNE1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

1.92e-0311799213GO:0099512
GeneOntologyCellularComponentvaricosity

BIN1 TRPM7

1.94e-0315922GO:0043196
GeneOntologyCellularComponentsupramolecular polymer

KNTC1 CACNA1C BIN1 DLC1 ANK1 IQGAP2 TTLL6 SYNE1 SPTAN1 SYNE2 CAPN3 RYR1 RYR2

2.04e-0311879213GO:0099081
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1C CATSPER1 NDUFAF1 TRPC4 CACHD1 RYR1 RYR2 ATP6V0A2

2.15e-03523928GO:1902495
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1C CATSPER1 TRA DAB2 CACHD1 CTNND1 GABBR2 TRAV38-2DV8 TRAV38-1 RYR1

2.36e-037859210GO:0098797
GeneOntologyCellularComponentcondensed chromosome

KNTC1 BRCA2 CENPF BUB1 SMC6 KNL1

2.37e-03307926GO:0000793
GeneOntologyCellularComponentcortical cytoskeleton

DLC1 ANK1 SPTAN1 TRPC4

2.54e-03129924GO:0030863
GeneOntologyCellularComponenttransporter complex

CACNA1C CATSPER1 NDUFAF1 TRPC4 CACHD1 RYR1 RYR2 ATP6V0A2

2.93e-03550928GO:1990351
GeneOntologyCellularComponentreplication fork

TIPIN ETAA1 RFC3

4.77e-0377923GO:0005657
MousePhenoabnormal prenatal growth/weight/body size

WDR91 FKBP10 BPTF TCTN3 BMPR2 DLC1 ANK1 TIAL1 BRCA2 TRPM7 ARHGEF7 PRRC2C SPTAN1 SMC6 DAB2 ZMYM2 DAAM1 MED23 ACE RYR1 RYR2

2.70e-0614936621MP:0004196
MousePhenolethality throughout fetal growth and development

CACNA1C TCTN3 BMPR2 BRCA2 ARHGEF7 SPTAN1 DAAM1 MED23 RYR1 RYR2

3.40e-054356610MP:0006208
MousePhenodecreased calcium uptake by cardiac muscle

CACNA1C CDK5RAP1

6.57e-053662MP:0012557
MousePhenoabnormal embryonic growth/weight/body size

WDR91 BPTF TCTN3 BMPR2 DLC1 TIAL1 BRCA2 TRPM7 ARHGEF7 PRRC2C SPTAN1 SMC6 DAB2 ZMYM2 MED23 ACE RYR2

7.65e-0512956617MP:0002088
MousePhenoembryonic lethality during organogenesis, complete penetrance

BPTF TCTN3 BMPR2 DLC1 BRCA2 ARHGEF7 KIAA0586 BUB1 SMC6 DAB2 MED23 RYR2

9.22e-057006612MP:0011098
MousePhenoabnormal muscle fiber morphology

CACNA1C BIN1 ANK1 SYNE1 CAPN3 CDK5RAP1 DAAM1 RYR1 RYR2

1.15e-04406669MP:0004087
MousePhenoabnormal sarcoplasmic reticulum morphology

ANK1 RYR1 RYR2

1.66e-0423663MP:0004088
MousePhenoabnormal embryonic tissue morphology

CACNA1C FKBP10 BPTF TCTN3 BMPR2 DLC1 BRCA2 ARHGEF7 PRRC2C SPTAN1 KIAA0586 DAB2 ARHGAP29 ZMYM2 MED23

1.72e-0411166615MP:0002085
MousePhenoabnormal prenatal body size

WDR91 BPTF TCTN3 ANK1 TIAL1 BRCA2 TRPM7 ARHGEF7 PRRC2C SPTAN1 SMC6 DAB2 DAAM1 MED23 ACE

1.72e-0411166615MP:0010866
MousePhenoprenatal growth retardation

FKBP10 BPTF BMPR2 DLC1 BRCA2 ARHGEF7 SPTAN1 SMC6 ZMYM2 MED23 ACE RYR1 RYR2

1.78e-048696613MP:0010865
MousePhenoembryonic lethality during organogenesis

BPTF TCTN3 BMPR2 DLC1 BRCA2 ARHGEF7 SPTAN1 KIAA0586 BUB1 SMC6 DAB2 MED23 RYR2

1.93e-048766613MP:0006207
MousePhenoabnormal skeletal muscle fiber triad morphology

ANK1 RYR1

2.18e-045662MP:0009411
MousePhenoabnormal intracellular organelle morphology

FKBP10 BRCA2 IQGAP2 SYNE2 KIAA0586 BUB1 CDK5RAP1 CTNND1 RYR1 RYR2

2.24e-045466610MP:0014239
MousePhenoimpaired exercise endurance

CACNA1C ANK1 SYNE1 CDK5RAP1

2.94e-0468664MP:0012106
MousePhenoskeletal muscle degeneration

ANK1 CAPN3 RYR1

3.73e-0430663MP:0009415
MousePhenoabnormal chorion morphology

BPTF ARHGEF7 DAB2 MED23

4.07e-0474664MP:0002836
MousePhenoabnormal embryo size

WDR91 BPTF TCTN3 TIAL1 BRCA2 TRPM7 ARHGEF7 PRRC2C SPTAN1 SMC6 DAB2 MED23 ACE

4.52e-049566613MP:0001697
MousePhenoabnormal muscle electrophysiology

CACNA1C ANK1 RYR1

4.52e-0432663MP:0004145
MousePhenoabsent anterior visceral endoderm

BPTF DAB2

4.54e-047662MP:0012159
MousePhenoabnormal sarcomere morphology

BIN1 CAPN3 DAAM1 RYR1

4.73e-0477664MP:0004090
MousePhenoabnormal muscle fiber mitochondrial morphology

CDK5RAP1 RYR1 RYR2

4.96e-0433663MP:0014342
MousePhenofatigue

CACNA1C ANK1 SYNE1 CDK5RAP1

4.97e-0478664MP:0002899
MousePhenoembryonic lethality between implantation and placentation, complete penetrance

BPTF BMPR2 BRCA2 TRPM7 ARHGEF7 BUB1 DAB2 ARHGAP29 KNL1

5.86e-04506669MP:0011095
MousePhenoabnormal calcium ion homeostasis

CACNA1C TCTN3 CATSPER1 ANK1 TIAL1 SMC6 CACHD1 RYR1

6.02e-04404668MP:0004231
MousePhenoincreased fibroblast cell migration

DLC1 ARHGEF7

6.04e-048662MP:0011709
MousePhenoabnormal exercise endurance

CACNA1C ANK1 SYNE1 CDK5RAP1

6.89e-0485664MP:0002332
DomainIon_trans_dom

CACNA1C CATSPER1 TRPM3 TRPM7 TRPC4 RYR1 RYR2 ITPR2

7.04e-08114898IPR005821
DomainIon_trans

CACNA1C CATSPER1 TRPM3 TRPM7 TRPC4 RYR1 RYR2 ITPR2

7.04e-08114898PF00520
DomainRIH_assoc

RYR1 RYR2 ITPR2

2.07e-066893PF08454
DomainRIH_assoc-dom

RYR1 RYR2 ITPR2

2.07e-066893IPR013662
DomainRIH_dom

RYR1 RYR2 ITPR2

2.07e-066893IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2 ITPR2

2.07e-066893IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2 ITPR2

2.07e-066893IPR015925
Domain-

RYR1 RYR2 ITPR2

2.07e-0668931.25.10.30
DomainRYDR_ITPR

RYR1 RYR2 ITPR2

2.07e-066893PF01365
DomainIns145_P3_rec

RYR1 RYR2 ITPR2

2.07e-066893PF08709
DomainMIR

RYR1 RYR2 ITPR2

1.23e-0510893PS50919
DomainMIR

RYR1 RYR2 ITPR2

1.23e-0510893PF02815
DomainMIR

RYR1 RYR2 ITPR2

1.23e-0510893SM00472
DomainMIR_motif

RYR1 RYR2 ITPR2

1.23e-0510893IPR016093
DomainRyanrecept_TM4-6

RYR1 RYR2

6.72e-053892IPR009460
DomainRyR

RYR1 RYR2

6.72e-053892PF02026
DomainRyanodine_rcpt

RYR1 RYR2

6.72e-053892IPR003032
DomainRR_TM4-6

RYR1 RYR2

6.72e-053892PF06459
DomainRyan_recept

RYR1 RYR2

6.72e-053892IPR013333
DomainEF-hand-dom_pair

CACNA1C FKBP10 SYNRG REPS1 SPTAN1 CAPN3 RYR1 RYR2

6.78e-05287898IPR011992
DomainKASH

SYNE1 SYNE2

1.34e-044892PF10541
DomainKASH

SYNE1 SYNE2

1.34e-044892IPR012315
DomainTRPM_tetra

TRPM3 TRPM7

1.34e-044892IPR032415
DomainKASH

SYNE1 SYNE2

1.34e-044892PS51049
DomainTRPM_tetra

TRPM3 TRPM7

1.34e-044892PF16519
DomainKASH

SYNE1 SYNE2

1.34e-044892SM01249
DomainSpectrin

SYNE1 SPTAN1 SYNE2

1.73e-0423893PF00435
Domain-

FKBP10 SYNRG REPS1 SPTAN1 CAPN3 RYR1 RYR2

2.49e-042618971.10.238.10
DomainCH

IQGAP2 ARHGEF7 SYNE1 SYNE2

2.61e-0465894SM00033
DomainCH

IQGAP2 ARHGEF7 SYNE1 SYNE2

3.47e-0470894PF00307
DomainSpectrin_repeat

SYNE1 SPTAN1 SYNE2

3.49e-0429893IPR002017
Domain-

IQGAP2 ARHGEF7 SYNE1 SYNE2

3.67e-04718941.10.418.10
DomainCH

IQGAP2 ARHGEF7 SYNE1 SYNE2

4.08e-0473894PS50021
DomainCH-domain

IQGAP2 ARHGEF7 SYNE1 SYNE2

4.52e-0475894IPR001715
DomainSpectrin/alpha-actinin

SYNE1 SPTAN1 SYNE2

4.69e-0432893IPR018159
DomainSPEC

SYNE1 SPTAN1 SYNE2

4.69e-0432893SM00150
DomainEF-hand_8

CAPN3 RYR1 RYR2

5.62e-0434893PF13833
DomainEF_hand_dom

FKBP10 REPS1 SPTAN1 CAPN3 RYR1 RYR2

8.48e-04232896IPR002048
DomainEH

SYNRG REPS1

1.20e-0311892PS50031
DomainEH

SYNRG REPS1

1.20e-0311892SM00027
DomainEH_dom

SYNRG REPS1

1.20e-0311892IPR000261
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM3 TRPM7 TRPC4 UNC79 RYR1 RYR2

1.11e-0599726MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM3 TRPM7 TRPC4 UNC79 RYR1 RYR2

1.64e-05106726M27200
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1C RYR1 RYR2

2.05e-0511723M47958
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM3 TRPM7 TRPC4 UNC79 RYR1 RYR2 ATP6V0A2

3.12e-05176727MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM3 TRPM7 TRPC4 UNC79 RYR1 RYR2 ATP6V0A2

4.01e-05183727M997
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR2 ITPR2

1.17e-0419723M47760
PathwayREACTOME_CDC42_GTPASE_CYCLE

WDR91 DLC1 IQGAP2 ARHGEF7 ARHGAP29 DAAM1

1.38e-04155726M41808
PathwayREACTOME_TRP_CHANNELS

TRPM3 TRPM7 TRPC4

3.82e-0428723MM14943
PathwayREACTOME_TRP_CHANNELS

TRPM3 TRPM7 TRPC4

3.82e-0428723M27241
PathwayKEGG_MEDICUS_REFERENCE_DYNEIN_RECRUITMENT_TO_THE_KINETOCHORE

KNTC1 CENPF BUB1

4.70e-0430723M47889
PathwayKEGG_MEDICUS_REFERENCE_HOMOLOGOUS_RECOMBINATION

BRCA2 RFC3 POLK

6.24e-0433723M47842
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

KNTC1 CENPF BUB1 DAAM1 KNL1

7.38e-04140725M27550
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1C TRPM7 TRPC4 RYR1 RYR2 ITPR2

8.00e-103893630786075
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

BPTF SYNRG LIMA1 ZBTB33 REPS1 PRRC2C SPTAN1 PDCD11 BOD1L1 CTNND1 MED23 MED17

2.77e-08549931238280479
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

WDR91 BIN1 LIMA1 IQGAP2 CENPF ARHGEF7 PRRC2C SYNE1 SPTAN1 TRPC4 SYNE2 ZMYM2 CTNND1 GABBR2 UNC79

4.04e-08963931528671696
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR1 RYR2 ITPR2

7.39e-08493319120137
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2 ITPR2

3.68e-07693323463619
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2 ITPR2

3.68e-07693325966694
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2 ITPR2

3.68e-07693320519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2 ITPR2

3.68e-07693316844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2 ITPR2

6.43e-07793311860456
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

CACNA1C RYR1 RYR2

1.03e-06893311784029
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2 ITPR2

1.03e-06893319033399
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SYNRG LIMA1 ZBTB33 REPS1 BRCA2 NAB1 ZMYM2 MED23 POLK

3.10e-0644493934795231
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SYNRG LIMA1 BMPR2 DLC1 TRPM7 PRRC2C SPTAN1 SYNE2 BOD1L1 ITPRID2 HNRNPUL1 CTNND1

3.26e-06861931236931259
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

BRCA2 CENPF SMC6 ETAA1 BOD1L1 HNRNPUL1 MED17 ZHX1 KNL1

3.65e-0645393929656893
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

CACNA1C RYR1 RYR2

4.00e-061293319095005
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

KNTC1 SYNRG BRCA2 PRRC2C BUB1 TSEN34 ZMYM2 ITPRID2 POLK KNL1

4.06e-06588931038580884
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

LIMA1 ZBTB33 CENPF PRRC2C SPTAN1 CTNND1 KNL1

5.96e-0625693733397691
Pubmed

P120 catenin represses transcriptional activity through Kaiso in endothelial cells.

ZBTB33 CTNND1

7.07e-06293220382170
Pubmed

The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.

ZBTB33 CTNND1

7.07e-06293212087177
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

7.07e-06293211792814
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

7.07e-06293224931616
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

7.07e-06293217259277
Pubmed

The SNP rs560426 Within ABCA4-ARHGAP29 Locus and the Risk of Nonsyndromic Oral Clefts.

ABCA4 ARHGAP29

7.07e-06293231950859
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

7.07e-06293214722100
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

7.07e-06293226009179
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

7.07e-06293232899693
Pubmed

Kaiso is a genome-wide repressor of transcription that is essential for amphibian development.

ZBTB33 CTNND1

7.07e-06293215548582
Pubmed

Mitochondrial calcium overload is a key determinant in heart failure.

RYR2 ITPR2

7.07e-06293226217001
Pubmed

Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores.

CENPF BUB1

7.07e-06293220660191
Pubmed

The POZ-ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine.

ZBTB33 CTNND1

7.07e-06293224040197
Pubmed

NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression.

ZBTB33 CTNND1

7.07e-06293215138284
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

7.07e-06293215033925
Pubmed

Ryanodine receptor-ankyrin interaction regulates internal Ca2+ release in mouse T-lymphoma cells.

ANK1 RYR1

7.07e-0629327629097
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

7.07e-06293222768332
Pubmed

Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.

ZBTB33 CTNND1

7.07e-06293228769046
Pubmed

Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.

RYR2 ITPR2

7.07e-06293228158491
Pubmed

Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells.

BUB1 KNL1

7.07e-06293231315522
Pubmed

BIN1 localizes the L-type calcium channel to cardiac T-tubules.

CACNA1C BIN1

7.07e-06293220169111
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

7.07e-06293217267447
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

7.07e-06293224718612
Pubmed

Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit.

CACNA1C RYR2

7.07e-06293211576544
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

7.07e-06293224586179
Pubmed

The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.

BUB1 KNL1

7.07e-06293219141287
Pubmed

Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition.

ZBTB33 CTNND1

7.07e-06293222590627
Pubmed

Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3.

ANK1 SPTAN1

7.07e-0629322970468
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

7.07e-06293230542613
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

7.07e-06293217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

7.07e-06293231578382
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

7.07e-06293215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

7.07e-06293211673493
Pubmed

The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin.

ZBTB33 CTNND1

7.07e-06293215817151
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

7.07e-06293211673462
Pubmed

Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression.

CACNA1C RYR1

7.07e-06293218927079
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

7.07e-06293225370123
Pubmed

Knockdown of both p120 catenin and Kaiso promotes expansion of human corneal endothelial monolayers via RhoA-ROCK-noncanonical BMP-NFκB pathway.

ZBTB33 CTNND1

7.07e-06293224474278
Pubmed

Association of CACNA1C and SYNE1 in offspring of patients with psychiatric disorders.

CACNA1C SYNE1

7.07e-06293227620326
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

7.07e-06293218618700
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

BPTF ZBTB33 TIAL1 BRCA2 PRRC2C SMC6 ZMYM2 PDCD11 BOD1L1 HNRNPUL1 RFC3 KNL1

9.19e-06954931236373674
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

FKBP10 NDUFAF1 TRPM7 SYNE1 SPTAN1 SYNE2 CDK5RAP1 PDCD11 PDZD8 ITPRID2 DAAM1 HNRNPUL1 CTNND1 ATP6V0A2 ITPR2

9.21e-061487931533957083
Pubmed

Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.

CACNA1C BIN1 RYR1

1.01e-051693332994313
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

CACNA1C RYR2 ITPR2

1.22e-051793327725084
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

BPTF LIMA1 TIAL1 CENPF SYNE1 SYNE2 PDCD11 ITPRID2 HNRNPUL1 CTNND1 RFC3 ITPR2

1.85e-051024931224711643
Pubmed

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

BIN1 ANK1

2.12e-05393225129075
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2

2.12e-05393218403125
Pubmed

Kaiso interacts with p120-catenin to regulate β-catenin expression at the transcriptional level.

ZBTB33 CTNND1

2.12e-05393224498333
Pubmed

Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.

BUB1 KNL1

2.12e-05393225661489
Pubmed

Nuclear import of the BTB/POZ transcriptional regulator Kaiso.

ZBTB33 CTNND1

2.12e-05393215564377
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2

2.12e-0539327876312
Pubmed

Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.

RYR1 RYR2

2.12e-05393224123915
Pubmed

An NGS-based genotyping in LQTS; minor genes are no longer minor.

CACNA1C RYR2

2.12e-05393232681117
Pubmed

Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells.

ZBTB33 CTNND1

2.12e-05393214699141
Pubmed

Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.

CACNA1C RYR1

2.12e-05393211206130
Pubmed

Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.

DLC1 KLRC2

2.12e-05393231502863
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

2.12e-05393216079285
Pubmed

Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.

BUB1 KNL1

2.12e-05393222331848
Pubmed

Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.

BRCA2 BUB1

2.12e-05393214646599
Pubmed

Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.

RYR1 RYR2

2.12e-05393223278119
Pubmed

P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.

ZBTB33 CTNND1

2.12e-05393222276175
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2

2.12e-05393222948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2

2.12e-05393210788707
Pubmed

The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor.

ZBTB33 CTNND1

2.12e-05393210207085
Pubmed

Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A.

SPTAN1 CAPN3

2.12e-0539329642272
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2

2.12e-0539327621815
Pubmed

Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression.

ZBTB33 CTNND1

2.12e-05393225713299
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2

2.12e-05393210473538
Pubmed

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.

BUB1 KNL1

2.12e-05393222660415
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2

2.12e-05393218434746
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

2.12e-05393210878022
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2

2.12e-0539329204703
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2

2.12e-05393221881589
Pubmed

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle.

CAPN3 RYR1

2.12e-05393218676612
Pubmed

Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.

ANK1 SPTAN1

2.12e-0539322141335
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2

2.12e-05393212213830
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

2.12e-05393212408964
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2

2.12e-0539329242641
Pubmed

Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.

ANK1 SPTAN1

2.12e-0539322971657
Pubmed

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

RYR1 RYR2

2.12e-05393223454728
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

2.12e-05393217462627
Pubmed

p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7.

ZBTB33 CTNND1

2.12e-05393218653469
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

RYR1 ITPR2

2.12e-05393223223241
InteractionPML interactions

TCTN3 SYNRG LIMA1 ZBTB33 ZFYVE9 REPS1 SYNE2 NAB1 SMC6 ZMYM2 MED23 MED17 POLK KNL1 ITPR2

1.52e-059339015int:PML
InteractionPHLPP1 interactions

LIMA1 ZBTB33 CENPF ARHGEF7 PRRC2C SPTAN1 DAB2 CTNND1 KNL1

1.80e-05333909int:PHLPP1
InteractionCDC42 interactions

WDR91 FKBP10 LIMA1 BMPR2 TENM3 IQGAP2 TRPM7 ARHGEF7 SYNE1 SPTAN1 SYNE2 ARHGAP29 DCBLD1 PDZD8 DAAM1 CTNND1 RFC3 ITPR2

1.87e-0513239018int:CDC42
InteractionRHOA interactions

LIMA1 BMPR2 DLC1 ZFYVE9 TENM3 TRPM7 SPTAN1 SYNE2 DAB2 ARHGAP29 DCBLD1 PDCD11 PDZD8 DAAM1 CTNND1 ATP6V0A2 ITPR2

1.96e-0511999017int:RHOA
InteractionNUP43 interactions

BPTF BRCA2 PRRC2C DDX60 SYNE2 ZMYM2 PDCD11 BOD1L1 ITPRID2 ZHX1 RYR2 KNL1

2.15e-056259012int:NUP43
InteractionRHOQ interactions

BMPR2 ZFYVE9 IQGAP2 TRPM7 ARHGEF7 SPTAN1 PDZD8 CACHD1 DAAM1 CTNND1

2.78e-054429010int:RHOQ
InteractionPRELID2 interactions

BRCA2 BUB1 KNL1

5.60e-0517903int:PRELID2
Cytoband2q14

BIN1 BUB1

2.21e-04119322q14
CytobandEnsembl 112 genes in cytogenetic band chr13q13

BRCA2 TRPC4 RFC3

6.35e-0482933chr13q13
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

3.58e-053632287
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

7.14e-0546321252
GeneFamilyTransient receptor potential cation channels

TRPM3 TRPM7 TRPC4

1.24e-0428633249
GeneFamilyEF-hand domain containing

FKBP10 REPS1 SPTAN1 CAPN3 RYR2

9.89e-04219635863
CoexpressionGSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_UP

WDR91 KIZ TRPC4 BUB1 ETAA1 DCBLD1 IRAK2 KNL1

3.09e-07188918M8452
CoexpressionHALLMARK_MITOTIC_SPINDLE

KNTC1 BIN1 BRCA2 CENPF ARHGEF7 SPTAN1 BUB1 ARHGAP29

4.75e-07199918M5893
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

KNTC1 BPTF LIMA1 IQGAP2 SYNE2 SMC6 ETAA1 DAAM1 POLK ZHX1 KNL1 ITPR2

2.84e-066569112M18979
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP

BRCA2 CENPF TIPIN BUB1 HNRNPUL1 RFC3 KNL1

4.11e-06187917M2984
CoexpressionEPPERT_PROGENITOR

KNTC1 DLC1 ANK1 TIPIN PDZD8 RFC3

8.82e-06138916M19232
CoexpressionPUJANA_BRCA2_PCC_NETWORK

KNTC1 TIAL1 BRCA2 CENPF ARHGEF7 BUB1 PFDN4 HNRNPUL1 RFC3

1.76e-05426919M9516
CoexpressionKENNY_CTNNB1_TARGETS_UP

SEPHS2 SYNE1 CAPN3 ETAA1

2.77e-0550914M11067
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_NK_CELL

KNTC1 BRCA2 CENPF TIPIN SYNE2 BUB1 SMC6 DAB2 RFC3 KLRC2 KNL1

2.87e-056949111M45767
CoexpressionGSE6269_HEALTHY_VS_STAPH_AUREUS_INF_PBMC_UP

BPTF LIMA1 DDX60 SMC6 RFC3 ATP6V0A2

2.98e-05171916M5655
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP

BRCA2 CENPF DDX60 TIPIN BUB1 HNRNPUL1

4.35e-05183916M2993
CoexpressionGSE14415_TCONV_VS_FOXP3_KO_INDUCED_TREG_DN

KNTC1 SEPHS2 TIPIN BUB1 RFC3 KNL1

4.62e-05185916M2965
CoexpressionGSE3982_CENT_MEMORY_CD4_TCELL_VS_TH1_UP

FKBP10 BIN1 ZFYVE9 ZNF337 CAPN3 TEX28

6.74e-05198916M5586
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_PROMONOCYTE_LIKE_CELL

KNTC1 RNASE3 BRCA2 CENPF BUB1 RFC3 KNL1

6.91e-05290917M45736
CoexpressionGSE24634_NAIVE_CD4_TCELL_VS_DAY7_IL4_CONV_TREG_DN

KNTC1 LIMA1 NDUFAF1 BUB1 RFC3 ITPR2

7.12e-05200916M4593
CoexpressionGSE27786_LIN_NEG_VS_ERYTHROBLAST_DN

KNTC1 KIZ SYNE2 IRAK2 DAAM1 KNL1

7.12e-05200916M4793
CoexpressionGSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_2H_UP

NDUFAF1 IQGAP2 SPTAN1 SYNE2 ZMYM2 ATP6V0A2

7.12e-05200916M6090
CoexpressionAIZARANI_LIVER_C20_LSECS_3

LIMA1 BMPR2 DLC1 ARHGEF7 DAB2 ARHGAP29 DAAM1

7.69e-05295917M39121
CoexpressionGAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN

BRCA2 PDZD8 PFDN4 ITPR2

8.31e-0566914M12812
CoexpressionHOWARD_NK_CELL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_3DY_UP

BRCA2 CENPF BUB1 KNL1

9.34e-0568914M41108
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_CYCLING_DEFINITIVE_ERYTHROBLAST

ANK1 BRCA2 IQGAP2 CENPF BUB1 KIAA1586 RFC3 KNL1

1.74e-04450918M45747
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP

KNTC1 BRCA2 CENPF TIPIN KIAA0586 BUB1 ETAA1 RFC3 KNL1

1.82e-04578919M2368
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

BPTF DLC1 ZFYVE9 BRCA2 CENPF ARHGEF7 PRRC2C SYNE2 ARHGAP29 ZMYM2 DAAM1

1.85e-048569111M4500
CoexpressionGSE14415_NATURAL_TREG_VS_FOXP3_KO_NATURAL_TREG_UP

DDX60 KIZ SYNE1 KLRC2 ITPR2

1.91e-04152915M2964
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

BPTF DLC1 ZFYVE9 CENPF ARHGEF7 PRRC2C ARHGAP29 ZMYM2

2.20e-04466918M13522
CoexpressionGOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP

KNTC1 BRCA2 CENPF TIPIN KIAA0586 BUB1 ETAA1 RFC3 KNL1

2.32e-04597919MM1309
CoexpressionLAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2

KCNT2 TENM3 SYNE1 ARHGAP29

2.32e-0486914M39248
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

BPTF ZBTB33 ZFYVE9 REPS1 BRCA2 CENPF ARHGEF7 SYNE2 KIAA0586 SMC6 ZMYM2 BOD1L1 HNRNPUL1 MED23 KNL1

5.05e-086298915Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

CATSPER1 BRCA2 CENPF KIZ SYNE2 KIAA0586 SMC6 ZMYM2 BOD1L1 KNL1

7.20e-073118910Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

XYLT1 KNTC1 BPTF CFAP54 ABCA4 KCNT2 BRCA2 TRPM7 CENPF ARHGEF7 SPTAN1 SYNE2 KIAA0586 BUB1 SMC6 ETAA1 ZMYM2 BOD1L1 HNRNPUL1 KNL1

7.41e-0713708920facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500_K1

CACNA1C LIMA1 ZBTB33 BRCA2 TRPM7 CENPF TIPIN BUB1 SMC6 ETAA1 ZMYM2 BOD1L1 PFDN4 RFC3 ACE KNL1 ITPR2

1.34e-0512418917facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

BPTF ZBTB33 ZFYVE9 REPS1 KCNT2 ARHGEF7 SYNE2 KIAA0586 PDZD8 BOD1L1 HNRNPUL1

3.85e-055958911Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlasFetal Liver, SC.STSL.FL, IgM- CD24- CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Fetal Liver, avg-2

KNTC1 BMPR2 BRCA2 CENPF TIPIN SYNE2 BUB1 CTNND1 KNL1

5.56e-05410899GSM791122_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000

WDR91 LIMA1 CATSPER1 REPS1 BRCA2 CENPF SYNE1 SYNE2 SMC6 ZMYM2 IRAK2 BOD1L1 MED17 KNL1

6.04e-059898914Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3

LIMA1 CATSPER1 REPS1 BRCA2 SYNE1 SMC6 ZMYM2 BOD1L1 KNL1

8.29e-05432899Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500

CACNA1C LIMA1 ZBTB33 BRCA2 TRPM7 CENPF TIPIN BUB1 SMC6 ETAA1 ZMYM2 BOD1L1 PFDN4 RFC3 ACE KNL1 ITPR2

1.11e-0414688917facebase_RNAseq_e10.5_MandArch_2500
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

BPTF ZBTB33 ZFYVE9 REPS1 KIAA0586 HNRNPUL1 MED23 ZHX1 KNL1 ITPR2

1.25e-045648910Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

XYLT1 CFAP54 BRCA2 IQGAP2 TRPM7 CENPF ARHGEF7 SYNE2 KIAA0586 BUB1 SMC6 ZMYM2 BOD1L1 KNL1

1.26e-0410608914facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasStromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4

FKBP10 BMPR2 DLC1 ZFYVE9 DAB2 ARHGAP29 DCBLD1 CTNND1 ACE

1.31e-04459899GSM777037_500
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1

ZFYVE9 REPS1 BRCA2 CENPF PRRC2C KIZ BUB1 ETAA1 CTNND1

1.54e-04469899Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

TCTN3 BRCA2 CENPF ARHGEF7 KIZ TIPIN SYNE2 KIAA0586 SMC6 ZMYM2 BOD1L1 KNL1

1.78e-048318912Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

XYLT1 BPTF ZBTB33 KCNT2 BRCA2 TRPM7 CENPF SYNE2 KIAA0586 BUB1 SMC6 ETAA1 ZMYM2 BOD1L1 KNL1

2.15e-0412578915facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500

CACNA1C ANK1 BRCA2 IRAK2 BOD1L1 DAAM1 RFC3 KNL1 ITPR2

2.20e-04492899Facebase_RNAseq_e10.5_Mandibular Arch_500
CoexpressionAtlasB cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2

KNTC1 BRCA2 IQGAP2 CENPF TIPIN SYNE2 BUB1 KNL1

2.25e-04388898GSM538352_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#1_top-relative-expression-ranked_500

CFAP54 ARHGAP29 RYR2 ITPR2

2.79e-0475894gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k1_500
CoexpressionAtlasalpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3

KNTC1 BRCA2 CENPF TIPIN BUB1 RFC3 KLRC2 KNL1

3.26e-04410898GSM538387_500
CoexpressionAtlasB cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2

KNTC1 BRCA2 CENPF TIPIN BUB1 CTNND1 RFC3 KNL1

3.77e-04419898GSM538348_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

TCTN3 CATSPER1 REPS1 BRCA2 CENPF KIZ TIPIN SYNE2 KIAA0586 ZMYM2 POLK

4.12e-047808911Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

NDUFAF1 TRPM7 ARHGEF7 PRRC2C SYNE2 KIAA0586 USP40 ARHGAP29 RYR1 RYR2 ITPR2

4.83e-047958911gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000

KNTC1 NDUFAF1 CENPF KIZ BUB1 CDK5RAP1 MED23

5.02e-04333897gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlasB cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3

KNTC1 CENPF BUB1 KNL1

5.14e-0488894GSM399452_100
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

FKBP10 LIMA1 DLC1 TENM3 SYNE2 ARHGAP29 CTNND1 ACE

5.60e-04445898GSM777043_500
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000

KNTC1 NDUFAF1 BRCA2 CENPF KIZ SPTAN1 KIAA0586 BUB1 CDK5RAP1 PDCD11 MED23

5.64e-048108911gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k-means-cluster#4_top-relative-expression-ranked_500

ZBTB33 DLC1 TIAL1 RYR2

6.08e-0492894DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k4_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#5_top-relative-expression-ranked_500

ZBTB33 DLC1 TIAL1 IQGAP2 RYR2

6.54e-04165895DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k5_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_500

ARHGAP29 DCBLD1 RYR2 ITPR2

6.60e-0494894gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_500
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

LIMA1 CFAP54 ZBTB33 BRCA2 TRPM7 CENPF SYNE2 BUB1 SMC6 ETAA1 ZMYM2 PDZD8 BOD1L1 KNL1

6.84e-0412528914facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000

LIMA1 RNASE3 REPS1 ANK1 BRCA2 CENPF KIZ SYNE2 KIAA0586 ZNF790 IRAK2 DAAM1

8.19e-049858912Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

CATSPER1 BRCA2 CENPF ARHGEF7 KIZ SYNE2 KIAA0586 SMC6 ZMYM2 BOD1L1 DAAM1 KNL1

8.48e-049898912Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BPTF BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

3.57e-10200929dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BPTF BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

3.57e-10200929a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

8.96e-0920092872ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

8.96e-092009285c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

8.96e-0920092881e76508c9050d533853d5fd2f3097b27613d836
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

8.96e-092009283585484c7e24e941708bee471ca607d8ccee74e6
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 ITPRID2 CTNND1 ACE

8.96e-092009284bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XYLT1 DLC1 BRCA2 CENPF TRPC4 BUB1 KNL1

6.76e-08171927b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XYLT1 DLC1 BRCA2 CENPF TRPC4 BUB1 KNL1

6.76e-08171927b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WDR91 CFAP54 ABCA4 TRPM3 SYNE1 SYNE2 ARHGAP29

1.20e-07186927f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

KNTC1 ANK1 BRCA2 CENPF BUB1 RFC3 KNL1

1.44e-07191927bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

KNTC1 ANK1 BRCA2 CENPF BUB1 RFC3 KNL1

1.65e-07195927764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellCOVID-19-lung-Proliferative_fibroblast|lung / Disease (COVID-19 only), tissue and cell type

CACNA1C FKBP10 TENM3 BRCA2 CENPF BUB1 KNL1

1.71e-071969272ce8a787f2731faa913d20342d73041d59468f27
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

BIN1 LIMA1 IQGAP2 SPTAN1 SYNE2 NAB1 PFDN4

1.77e-071979277c9df6025b9d168bd6d041c6cff1e87e08b11847
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

BPTF LIMA1 PRRC2C KIZ SYNE2 BOD1L1 DAAM1

1.90e-0719992719674e1eaeb51e4196d847cb62aa437c852951d3
ToppCellCOVID-19_Severe-immature_Neutrophil|COVID-19_Severe / Disease condition and Cell class

RNASE3 BRCA2 CENPF SYNE1 SYNE2 PDZD8 KNL1

1.90e-07199927f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCellCOVID-19_Severe-immature_Neutrophil-|COVID-19_Severe / Disease condition and Cell class

RNASE3 BRCA2 CENPF SYNE1 SYNE2 PDZD8 KNL1

1.90e-0719992742ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

BPTF LIMA1 PRRC2C KIZ SYNE2 SMC6 BOD1L1

1.90e-07199927a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 SYNE2 ARHGAP29 CTNND1 ACE

1.96e-07200927edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BMPR2 DDX60 SPTAN1 SYNE2 ARHGAP29 CTNND1 ACE

1.96e-0720092789821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

BPTF BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

1.96e-072009273b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMPR2 KCNT2 TRPM7 PRRC2C HNRNPUL1 RYR2

1.78e-06176926749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KNTC1 IQGAP2 BUB1 ETAA1 RFC3 KNL1

1.78e-061769269e719e6323597ecfc758c957256872cd4ae24d4d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 KCNT2 BRCA2 CENPF RFC3 KNL1

1.83e-06177926f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

1.96e-0617992688d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.02e-06180926401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.02e-06180926f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

BMPR2 SYNE1 SYNE2 ARHGAP29 GABBR2 ACE

2.09e-06181926c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XYLT1 CFAP54 KCNT2 TENM3 SYNE1 ARHGAP29

2.09e-061819265f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XYLT1 CFAP54 KCNT2 TENM3 SYNE1 ARHGAP29

2.09e-06181926c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMPR2 PRRC2C SYNE2 ARHGAP29 HNRNPUL1 ITPR2

2.44e-061869260ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.52e-061879269351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 BRCA2 CENPF BUB1 RYR1 KNL1

2.52e-0618792673931a5ea73799095daff100b5f18853c57c74dc
ToppCellNS-critical-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.68e-06189926d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCellPBMC-Severe-cDC_12|Severe / Compartment, Disease Groups and Clusters

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.76e-0619092684ee185939bdefb10705b621a70da27701eadcee
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

DLC1 ARHGEF7 TRPC4 SYNE2 ARHGAP29 DCBLD1

2.76e-06190926a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.76e-06190926d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellBac-SEP-Lymphocyte-T_NK-CD8_TEM|Bac-SEP / Disease, Lineage and Cell Type

PATL2 BIN1 LIMA1 SYNE1 SYNE2 KLRC2

2.85e-0619192684e3aaed71bd35d73af475d610d1b7e71df9ce3f
ToppCellMild-T/NK_proliferative|World / Disease group and Cell class

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

2.85e-061919269dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.03e-061939264b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

CACNA1C FKBP10 LIMA1 TENM3 TRPC4 RYR2

3.03e-06193926ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.12e-06194926f9070035553bc68106a9e0bdf4b507715a138aba
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BMPR2 DLC1 ARHGAP29 CACHD1 CTNND1 ACE

3.12e-061949260b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellCOVID-19_Moderate-CD8+_T_activated|World / disease group, cell group and cell class

PATL2 DDX60 SYNE1 SYNE2 PZP KLRC2

3.21e-06195926070c5d3bdbd4ea54a579c01c37fb99bcf823982e
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.21e-061959261a5e814e12fe37287dbfc58189e1958e2c76b5da
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.31e-061969261d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.31e-061969261964c5003a0cb84539850a7cfe3bbb0e23a61d2d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.31e-0619692673f951f7712e0aa3323676b9a4b7944d21d347c4
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.40e-0619792684ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.40e-061979268b616cde333bdbc0c591035ad9e4949155866245
ToppCellCOVID-19_Moderate-CD8+_T_activated|COVID-19_Moderate / disease group, cell group and cell class

PATL2 DDX60 SYNE1 SYNE2 PZP KLRC2

3.40e-061979264711ecb157e907758a5021248ae8b043d17672c6
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

CACNA1C FKBP10 DLC1 KCNT2 TENM3 RYR2

3.40e-06197926fb847f2277609c31fffcdf49517243ce0684facf
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PATL2 BIN1 SYNE1 SYNE2 PZP KLRC2

3.40e-0619792635004d4728d33f15cc3be99a073b1ea965365c32
ToppCellSepsis-URO-Lymphocyte-T/NK-CD4+_CTL|URO / Disease, condition lineage and cell class

PATL2 BIN1 SYNE1 SYNE2 PZP RYR2

3.51e-06198926c53405a8d082fbd10131a6ec88b69fdd835f2925
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1C SYNE1 SPTAN1 GABBR2 UNC79 RYR2

3.51e-061989268ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellmedial-2-Hematologic-Proliferating_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.51e-0619892664a2bcf5a9ba66a4fe08fbde33f1886c136cde8f
ToppCellmedial-Hematologic-Proliferating_Macrophage-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.51e-06198926fcc14ac3eb5088b9d6cd6af5a34dee5b81c0ece8
ToppCellmedial-Hematologic-Proliferating_Macrophage|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.51e-06198926da6963184c32761c896a9b91a5321ad84b583736
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-06199926e98ff036d04fc78dffef156bdc0d644532274067
ToppCellVE-cycling|VE / Condition, Cell_class and T cell subcluster

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-0619992647c47ebc318a0b98841ca2656837bbd068899559
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

BRCA2 CENPF SYNE2 BUB1 RFC3 KNL1

3.61e-06199926305a9ade5bbe8e981e7c641c9a5e0c9f8ef60470
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

BPTF LIMA1 KIZ SYNE2 SMC6 BOD1L1

3.61e-0619992618a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-061999267feedb0bf84a3361c8ab5b6674ff64e8ff140c23
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

BRCA2 CENPF SYNE1 SYNE2 BUB1 KNL1

3.61e-06199926101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-06199926123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BRCA2 CENPF SYNE1 SYNE2 BUB1 KNL1

3.61e-06199926e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-gd_T|Leuk-UTI / Disease, condition lineage and cell class

PATL2 BIN1 SYNE1 SYNE2 PZP KLRC2

3.61e-06199926b2c1b9ee764e1246bfa3ecf666ca76ae4ac6c362
ToppCellCOVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Severe / Disease group, lineage and cell class

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-06199926ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

BPTF LIMA1 PRRC2C SYNE2 SMC6 BOD1L1

3.61e-06199926c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BRCA2 CENPF SYNE2 BUB1 RFC3 KNL1

3.61e-06199926fba48342066aab41a8bcb20db40a6df0158e1cbe
ToppCellVE-cycling-|VE / Condition, Cell_class and T cell subcluster

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-06199926c0a67149a19b65b3069dbc5261d81f658e6e39a2
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.61e-061999266b1304417cf9c44ca70d2bfc2b5acc1a206f25b6
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

XYLT1 TENM3 SYNE1 GABBR2 PZP RYR2

3.61e-061999268b86c69aaf60feff53aa782559cfece7342a23de
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

KNTC1 BRCA2 CENPF SYNE2 BUB1 KNL1

3.61e-0619992698575fcce726589e93fbb4df1aab03e57cb56076
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KNTC1 BRCA2 CENPF SYNE2 BUB1 KNL1

3.61e-06199926be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

BRCA2 CENPF SYNE2 BUB1 RFC3 KNL1

3.71e-062009268f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

KNTC1 NDUFAF1 BRCA2 CENPF BUB1 HNRNPUL1

3.71e-06200926d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells|10w / Sample Type, Dataset, Time_group, and Cell type.

BRCA2 CENPF SYNE2 BUB1 RFC3 KNL1

3.71e-06200926a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCellTracheal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

XYLT1 FKBP10 CFAP54 KCNT2 TENM3 SYNE1

3.71e-06200926b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PATL2 PRRC2C DDX60 SYNE1 SYNE2 PZP

3.71e-06200926d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells-Neuroepithelial_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

BRCA2 CENPF SYNE2 BUB1 RFC3 KNL1

3.71e-062009260d9b8d51a7630e70e60c76c763ff82df4c559152
ToppCellsevere-T/NK_proliferative|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KNTC1 BRCA2 CENPF TIPIN BUB1 RFC3

3.71e-062009269d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-06200926eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellTracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

XYLT1 FKBP10 CFAP54 KCNT2 TENM3 SYNE1

3.71e-06200926f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells|2m / Sample Type, Dataset, Time_group, and Cell type.

BRCA2 CENPF SYNE2 BUB1 RFC3 KNL1

3.71e-062009260675f580ccef705875854247bbfd4ee2bcf126a1
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-CD8+_Tem|Bac-SEP / Disease, condition lineage and cell class

PATL2 BIN1 LIMA1 SYNE1 SYNE2 KLRC2

3.71e-0620092686e572b4fb01a429c1ad4b492214a128c0a430e3
ToppCellControl_saline-Endothelial-Endothelial-Alv_Gen_Intermediate|Control_saline / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-06200926041a34080120c9f613373c20dcc366292f558040
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-06200926b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-06200926e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BMPR2 SPTAN1 SYNE2 ARHGAP29 CTNND1 ACE

3.71e-0620092679e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell|GW13 / Sample Type, Dataset, Time_group, and Cell type.

KNTC1 NDUFAF1 BRCA2 CENPF BUB1 HNRNPUL1

3.71e-062009263d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells-Neuroepithelial_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.71e-06200926203b9a5de4430713da01b3331e69381db449a3a0
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-06200926f15fffefe372005c33e31845982e2d2714ac26af
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells|GW26 / Sample Type, Dataset, Time_group, and Cell type.

KNTC1 BRCA2 CENPF BUB1 RFC3 KNL1

3.71e-06200926a854e19703dc920e48304541e2b06ed013292f3e
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BPTF BMPR2 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-06200926b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 DDX60 ARHGAP29 CTNND1 ACE

3.71e-06200926be55cef682ba87250dad97689332c8820b3a7420
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

BMPR2 DLC1 SPTAN1 ARHGAP29 CTNND1 ACE

3.71e-062009263372c488a39fe812fa94e4f0564594186fea3db5
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-CD8+_Tem|Leuk-UTI / Disease, condition lineage and cell class

PATL2 BIN1 SYNE1 SYNE2 PZP KLRC2

3.71e-06200926aa8104dcb2ba5756a23c25a580bef2360ff25b13
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KNTC1 BRCA2 CENPF BUB1 KNL1

2.24e-051639255285318c52aa31c9b22dc2ffff078e32e408604d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 BRCA2 CENPF BUB1 KNL1

2.24e-051639253f434015c0cbefb31eeda133c34f75384c5f7e22
ComputationalNeighborhood of DFFA

ZBTB33 REPS1 NAB1 ZMYM2 BOD1L1 MED17

7.83e-05129606GCM_DFFA
DrugClozapine [5786-21-0]; Down 200; 12.2uM; PC3; HT_HG-U133A

ZBTB33 ZFYVE9 BRCA2 DDX60 SPTAN1 NAB1 ZMYM2 GABBR2 ITPR2

8.64e-081998994670_DN
Druglercanidipine

CACNA1C CATSPER1 ANK1 ACE RYR1 RYR2

1.71e-0763896CID000065866
DrugCinildipine

CACNA1C CATSPER1 ACE RYR1 RYR2

2.66e-0656895CID000002752
Drugnilvadipine

CACNA1C CATSPER1 ACE RYR1 RYR2

3.76e-0660895CID000004494
Drugstrontium

KNTC1 TRPM7 TRPC4 RYR1 RYR2

6.99e-0668895CID000104798
DrugAC1L2AC7

CACNA1C CATSPER1 ACE RYR1 RYR2

7.52e-0669895CID000068733
DrugCNS 1145

CACNA1C CATSPER1 RYR1 RYR2

8.18e-0633894CID000190902
DrugIHC-64

CACNA1C CATSPER1 RYR1 RYR2

8.18e-0633894CID000162753
Drugethosuximide

CACNA1C CATSPER1 GABBR2 RYR1 RYR2

1.06e-0574895CID000003291
DrugPiribedil hydrochloride [78213-63-5]; Up 200; 12uM; HL60; HT_HG-U133A

BIN1 ZFYVE9 ZNF337 SPTAN1 DAB2 RYR1 ITPR2

1.19e-051968972951_UP
DrugAir Pollutants

LIMA1 BMPR2 KCNT2 IQGAP2 CENPF TTLL6 ARHGEF7 KIZ SYNE2 DAB2 PFDN4 ITPRID2 CTNND1 ITPR2

1.23e-059178914ctd:D000393
Drugnisoldipine

CACNA1C CATSPER1 ACE RYR1 RYR2

1.37e-0578895CID000004499
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1C CATSPER1 ACE RYR1 RYR2

1.46e-0579895CID005287890
Druglanthanum

CACNA1C CATSPER1 TRPM7 TRPC4 RYR1 RYR2

1.57e-05136896CID000023926
DrugAC1L1DXE

CACNA1C CATSPER1 ANK1 TRPM3 TRPC4 GABBR2 RYR1 RYR2

2.26e-05299898CID000002548
DrugFPL 64176

CACNA1C RYR1 RYR2

2.54e-0515893CID000003423
Drugmanidipine

CACNA1C CATSPER1 ACE RYR1 RYR2

3.58e-0595895CID000004008
Drugnitrendipine

CACNA1C CATSPER1 ACE RYR1 RYR2

4.16e-0598895CID000004507
Drugcis-diammineplatinum(II

RYR1 RYR2

4.52e-053892CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2

4.52e-053892CID002750949
Drug8N3-cADPR

RYR1 RYR2

4.52e-053892CID000127713
Drugaminodantrolene

RYR1 RYR2

4.52e-053892CID009570289
Drug2-hydroxycarbazole

RYR1 RYR2

4.52e-053892CID000093551
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2

4.52e-053892CID005748312
Drugisradipine

CACNA1C CATSPER1 ACE RYR1 RYR2

4.58e-05100895CID000003784
Drugtorcetrapib

CACNA1C FKBP10 LIMA1 PRRC2C ARHGAP29 BOD1L1 ITPRID2 ITPR2

5.86e-05342898ctd:C483909
DrugBaclofen

GABBR2 RYR1 RYR2

6.27e-0520893ctd:D001418
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

KNTC1 BPTF ARHGEF7 DAAM1 RFC3 ATP6V0A2

8.30e-051838967498_DN
DrugHPED

RNASE3 SYNE1

9.02e-054892CID000125856
DrugPCB74

RYR1 RYR2

9.02e-054892CID000036218
Drug148504-47-6

RYR1 RYR2

9.02e-054892CID006444275
DrugSC 38249

RYR1 RYR2

9.02e-054892CID000134834
DrugAC1L1U7A

RYR1 RYR2

9.02e-054892CID000035682
DrugIAA-94

CACNA1C CATSPER1 RYR1 RYR2

9.60e-0561894CID000003667
DrugYM-09730-5

CACNA1C ACE ATP6V0A2

9.66e-0523893CID000002296
DrugNSC759576

CACNA1C CATSPER1 IQGAP2 ACE RYR1 RYR2

1.05e-04191896CID000003075
DrugSalbutamol [18559-94-9]; Down 200; 16.8uM; PC3; HT_HG-U133A

SYNE1 DAB2 ETAA1 ZMYM2 PFDN4 ITPR2

1.05e-041918967376_DN
Drugclozapine; Down 200; 10uM; HL60; HT_HG-U133A

BMPR2 ZFYVE9 CENPF DDX60 BUB1 RYR2

1.08e-041928966188_DN
Drugdihydropyridine

CACNA1C BIN1 CATSPER1 ACE RYR1 RYR2

1.11e-04193896CID000104822
DrugClofazimine [2030-63-9]; Down 200; 8.4uM; PC3; HT_HG-U133A

SYNRG ZFYVE9 TRPC4 BUB1 GABBR2 OAZ3

1.14e-041948964682_DN
Drugpioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A

BIN1 DLC1 ZMYM2 RYR1 RYR2 ITPR2

1.14e-041948967523_UP
Drugmibefradil

CACNA1C CATSPER1 ACE RYR1

1.16e-0464894CID000060662
DrugF0447-0125; Down 200; 10uM; MCF7; HT_HG-U133A

DLC1 SPTAN1 BUB1 ETAA1 ITPRID2 ITPR2

1.18e-041958966424_DN
DrugTacrine hydrochloride hydrate [1684-40-8]; Down 200; 15.8uM; PC3; HT_HG-U133A

FKBP10 ZBTB33 TENM3 SPTAN1 ZMYM2 OAZ3

1.18e-041958966698_DN
DrugBAS 012416453; Up 200; 38uM; MCF7; HT_HG-U133A

ZFYVE9 ARHGEF7 ETAA1 PDZD8 PFDN4 RFC3

1.24e-041978966908_UP
DrugNeomycin sulfate [1405-10-3]; Down 200; 4.2uM; PC3; HT_HG-U133A

ZFYVE9 BRCA2 ZNF337 KIAA0586 BUB1 TSEN34

1.24e-041978965867_DN
DrugSpaglumic acid [4910-46-7]; Up 200; 13.2uM; HL60; HT_HG-U133A

ZBTB33 ZFYVE9 SPTAN1 DAB2 PFDN4 ITPR2

1.28e-041988962962_UP
Drug5286656; Down 200; 50uM; MCF7; HT_HG-U133A_EA

SYNRG DLC1 PRRC2C ETAA1 ITPRID2 ITPR2

1.28e-04198896889_DN
DrugTheobromine [83-67-0]; Down 200; 22.2uM; HL60; HT_HG-U133A

BMPR2 ZNF337 SPTAN1 TRPC4 CTNND1 GABBR2

1.28e-041988962995_DN
DrugGlafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; HL60; HT_HG-U133A

BIN1 ZFYVE9 BRCA2 DAB2 CTNND1 GABBR2

1.28e-041988962387_UP
DrugCarteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; HL60; HT_HG-U133A

WDR91 BMPR2 ZFYVE9 ZNF337 SPTAN1 ETAA1

1.28e-041988961340_UP
DrugCeftazidime pentahydrate [78439-06-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A

WDR91 LIMA1 DLC1 ZFYVE9 BRCA2 PFDN4

1.32e-041998965473_DN
DrugGibberellic acid [77-06-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A

WDR91 FKBP10 ETAA1 ZMYM2 GABBR2 RYR2

1.32e-041998967330_DN
Druggadolinium

CACNA1C CATSPER1 TRPM3 TRPM7 RYR1 RYR2

1.32e-04199896CID000023982
Drugtetraethylenepentamine pentahydrochloride; Up 200; 100uM; MCF7; HG-U133A

WDR91 BRCA2 DAAM1 GABBR2 OAZ3 ITPR2

1.32e-04199896406_UP
DrugN-phenylanthranilic acid; Down 200; 10uM; MCF7; HG-U133A

WDR91 BMPR2 IQGAP2 ARHGEF7 SPTAN1 PDZD8

1.35e-04200896317_DN
Druggallopamil

CACNA1C CATSPER1 RYR1 RYR2

1.39e-0467894CID000001234
Drug2-aminoethyl diphenylborinate

CACNA1C TRPM3 TRPM7 TRPC4 RYR1

1.42e-04127895CID000001598
DrugA 68930

RYR1 RYR2

1.50e-045892ctd:C065380
DrugDemecolcine

LIMA1 REPS1 BRCA2 CENPF ARHGEF7 DDX60 SYNE2 NAB1 SMC6 IRAK2 DAAM1 MED17

1.55e-048788912ctd:D003703
DrugCAS 298-57-7

CACNA1C CATSPER1 RYR1 RYR2

1.93e-0473894CID000002761
Drug2,4-xylidinothiazoline

XYLT1 RYR1 RYR2

2.17e-0430893CID000099296
Drugchloro-m-cresol

RYR1 RYR2

2.24e-046892CID000012008
DrugMBED

RYR1 RYR2

2.24e-046892CID000129958
DrugAC1O528X

RYR1 RYR2

2.24e-046892CID006475857
DrugNSC114784

RYR1 RYR2

2.24e-046892CID000419425
DiseaseMalignant neoplasm of breast

BMPR2 ABCA4 ANK1 KCNT2 BRCA2 CENPF SYNE1 SPTAN1 TRPC4 SYNE2 SMC6 ARHGAP29 BOD1L1

1.75e-0510748813C0006142
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

2.63e-053882DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

2.63e-053882DOID:8545 (implicated_via_orthology)
DiseaseMyopathy, Centronuclear, Autosomal Recessive

BIN1 RYR1

5.26e-054882C0410204
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

5.26e-054882cv:CN293514
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

8.74e-055882C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

8.74e-055882C0410190
Diseasepulmonary hypertension (biomarker_via_orthology)

BMPR2 CTNND1 RYR1 RYR2

9.82e-0580884DOID:6432 (biomarker_via_orthology)
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.31e-046882cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

1.31e-046882C0410189
Diseaseprimary pulmonary hypertension (is_implicated_in)

BMPR2 RYR1

1.31e-046882DOID:14557 (is_implicated_in)
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.83e-047882C0751337
DiseaseMASA syndrome (implicated_via_orthology)

TRPM3 TRPM7

1.83e-047882DOID:0060246 (implicated_via_orthology)
Diseasebipolar disorder, schizophrenia

CACNA1C TTLL6 PDZD8

2.70e-0442883MONDO_0004985, MONDO_0005090
DiseaseMental deterioration

CACNA1C BIN1

3.12e-049882C0234985
DiseaseMild cognitive disorder

CACNA1C BIN1

3.12e-049882C1270972
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

BPTF BRCA2 SYNE2 CAPN3

3.47e-04111884EFO_0004530, EFO_0008595
Diseaseresponse to tenofovir, creatinine clearance measurement

TRPM3 DCBLD1 PZP RYR2

3.59e-04112884EFO_0007934, EFO_0009279
Diseaseaspartate aminotransferase measurement

WDR91 BIN1 ABCA4 TIAL1 IQGAP2 TRPM3 TRPM7 DAB2 ARHGAP29 KLRC2

3.61e-049048810EFO_0004736
DiseaseBRCA2 mutation carier statu

ETAA1 RFC3

3.90e-0410882EFO_0011022
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

5.69e-0412882DOID:11726 (implicated_via_orthology)
DiseaseAutosomal Dominant Myotubular Myopathy

BIN1 RYR1

6.71e-0413882C3661489
DiseaseCentronuclear myopathy

BIN1 RYR1

6.71e-0413882C0175709
DiseaseX-linked centronuclear myopathy

BIN1 RYR1

6.71e-0413882C0410203
DiseaseMyopathy, Centronuclear, 1

BIN1 RYR1

6.71e-0413882C4551952
DiseaseCongenital Structural Myopathy

BIN1 RYR1

6.71e-0413882C0752282
DiseaseMyopathy, Centronuclear, Autosomal Dominant

BIN1 RYR1

7.82e-0414882C1834558
DiseaseTubular Aggregate Myopathy

BIN1 RYR1

7.82e-0414882C0410207
DiseaseImpaired cognition

CACNA1C BIN1

7.82e-0414882C0338656
Diseaseanemia (is_implicated_in)

ANK1 ACE

7.82e-0414882DOID:2355 (is_implicated_in)
DiseaseAutosomal Recessive Centronuclear Myopathy

BIN1 RYR1

9.00e-0415882C3645536
Diseasemyocardial infarction (implicated_via_orthology)

DAB2 ACE RYR1

1.02e-0366883DOID:5844 (implicated_via_orthology)
Diseaseprimary autosomal recessive microcephaly (is_implicated_in)

BUB1 KNL1

1.03e-0316882DOID:0070296 (is_implicated_in)
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 CAPN3

1.16e-0317882DOID:9884 (is_implicated_in)
Diseasesphingomyelin 14:0 measurement

TRPM3 SYNE2

1.16e-0317882EFO_0010390
Diseaseunipolar depression, bipolar disorder

CACNA1C AREL1 SYNE1 SYNE2

1.24e-03156884EFO_0003761, MONDO_0004985
DiseaseCongenital Fiber Type Disproportion

BIN1 RYR1

1.30e-0318882C0546264
DiseaseColorectal Neoplasms

ABCA4 DLC1 TRPM7 SYNE1 BUB1

1.46e-03277885C0009404
Diseasenon-small cell lung carcinoma

BPTF BRCA2 DCBLD1

1.48e-0375883EFO_0003060
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

BPTF BRCA2 SYNE2 CAPN3

1.56e-03166884EFO_0004530, EFO_0004611
DiseaseIntellectual Disability

BPTF TRPM3 SYNE1 TSEN34 ZMYM2 MED23

2.23e-03447886C3714756
DiseaseCardiac Arrhythmia

CACNA1C ACE

2.52e-0325882C0003811
DiseaseColorectal cancer

DLC1 BUB1

2.94e-0327882cv:C0346629
DiseaseCOLORECTAL CANCER

DLC1 BUB1

2.94e-0327882114500
DiseaseNeoplasm of the large intestine

DLC1 BUB1

2.94e-0327882cv:C0009404

Protein segments in the cluster

PeptideGeneStartEntry
LVQAVSQNFNFAKDV

ACSM6

41

Q6P461
QQFNTNFDENKVDVT

CFAP54

156

Q96N23
QSVNFVNDGQKNSTR

ERVK-8

496

Q902F8
NEDAFEAQFQKNVRS

BUB1

496

O43683
VASVEQEQQKFRSQA

CATSPER1

746

Q8NEC5
LDQVFVNFAKQQTES

ABCA4

2241

P78363
GTQARKFDVNQLQNT

ACE

701

P12821
GQEEQVQEAKNTFTQ

ANK1

1781

P16157
FQLIRSTNNNTKFQA

CACHD1

321

Q5VU97
DNSNNQLVVRAKFNF

ARHGEF7

181

Q14155
QLVVRAKFNFQQTNE

ARHGEF7

186

Q14155
TVTFQQNKNFHQTFA

BPTF

2101

Q12830
VQDSQTFSTNFQVDN

PZP

1286

P20742
RDEQGSKVNDFFQQT

ITPR2

2186

Q14571
QFDQISNRTGKQEAQ

DAB2

346

P98082
KTNVDSVFVNFQNDR

OAZ3

171

Q9UMX2
NQDINTTQNIAEVFK

MUC15

26

Q8N387
VDNTFAEEFTTQNQK

LIMA1

711

Q9UHB6
ADVVQATDDFNQNRK

IRAK2

201

O43187
QQENDSIFKQNVTDG

ZBTB33

646

Q86T24
FQDSVQTLFQQARAK

NAB1

341

Q13506
VNQVAATVQNRFTKN

DDX60

821

Q8IY21
TFEDQQKINKFARNT

PFDN4

16

Q9NQP4
FREFVNNNIKSNNVS

KIAA1586

671

Q9HCI6
LTENKHSFQDTQFQN

PDZD8

836

Q8NEN9
NQNTFLRTTFANVVN

RNASE3

66

P12724
AFFKQNNVPQESRFN

MED23

741

Q9ULK4
DNQIFKQDQSNVQIA

KNL1

521

Q8NG31
TNAFVQKANDENRRT

KNTC1

121

P50748
VTENQENKLQRDFNS

MED17

171

Q9NVC6
SAFKNQDQQRKSNVS

KCNT2

561

Q6UVM3
TLQDNTNQTENRFQK

KIZ

571

Q2M2Z5
NFNQGTENEQSKETQ

ITPRID2

386

P28290
DVIQEQNKRNYDFTQ

ETAA1

206

Q9NY74
FSEQQSNQVEKLFQT

PATL2

331

C9JE40
NFTEVNEENKNDLFQ

ARHGAP29

116

Q52LW3
NEENKNDLFQEVFSS

ARHGAP29

121

Q52LW3
VFEVSKTQDNRNNNS

BOD1L1

1131

Q8NFC6
FDQFLQAVSEAKQEN

DAAM1

976

Q9Y4D1
FQNQDRNQDGKITVD

FKBP10

551

Q96AY3
NDTTEINRNNNFQTF

CACNA1C

1436

Q13936
QFNKNNSNQAVAVTF

BRCA2

2456

P51587
QVKESQVNFQEGQLN

CENPF

91

P49454
VNIKEDTDFFQRTNQ

NDUFAF1

221

Q9Y375
VFSFANRQNFINEKN

BMPR2

231

Q13873
TTNQLFTRFSDNNQA

AREL1

521

O15033
QNRRFQFTQNQKKED

GABBR2

756

O75899
IVNNEEKVFQGNSNF

DCBLD1

361

Q8N8Z6
DEQFEQCVQNFNKQL

BIN1

41

O00499
QESEEQQQFRNIFKQ

CAPN3

646

P20807
FKREEQNFVVQNEIN

RYR1

3451

P21817
NFKREEQNFVVQNEI

RYR2

3411

Q92736
KSDFQVNLNNASRSQ

CTNND1

846

O60716
AQSQQLETNSQRDFK

RFC3

116

P40938
RQNQFYDTQVIKQEN

HNRNPUL1

106

Q9BUJ2
SQFEVFAASNVNDEQ

REPS1

631

Q96D71
QEQITKANEEFQAFL

SYNE1

2486

Q8NF91
TERPQFSRQKDFQQQ

SYNE2

4371

Q8WXH0
QKQFAEEQQKRFEQQ

SYNRG

116

Q9UMZ2
FLEQNNFSPNTRTQK

KLRC2

96

P26717
DDLQTNQFKNVTFDI

IQGAP2

1496

Q13576
EVLQSTQRFFSEQQQ

PRRC2C

2816

Q9Y520
TQRFFSEQQQSKQIG

PRRC2C

2821

Q9Y520
TFNNVVEQNFKNRES

DLC1

786

Q96QB1
FRQKENDTQIFNDSA

SIX6OS1

316

Q8N1H7
QNVNSFRDNSEVQFN

CDK5RAP1

316

Q96SZ6
KAFQQSVEQDNLFDI

PDCD11

21

Q14690
SQNLAKQQRNEVSFV

SEPHS2

326

Q99611
ENVDNSNFAPRTQKQ

XYLT1

161

Q86Y38
QNSVTFQEVAVDFSQ

ZNF177

11

Q13360
FKRQQEESFQEQSAL

TSEN34

86

Q9BSV6
QQNATENRFSVNFQK

TRA

76

P0DTU3
VFNNTFFEVKSISNQ

TRPM3

1136

Q9HCF6
EANKQQNFNTGIKDF

SPTAN1

1656

Q13813
EAVNKQSFQTSQPFQ

POLK

586

Q9UBT6
VKRNNQTIFEQTIND

ZHX1

136

Q9UKY1
RVKAFQNQENSVNQE

SMC6

416

Q96SB8
QQTENDTFENGKVNS

TENM3

341

Q9P273
FQDNNSLFQNTVASR

TTLL6

461

Q8N841
AVFNTQKRENAEENN

ZNF33A

231

Q06730
ETNQGQEKNSSNFIE

ZMYM2

126

Q9UBW7
QFQTLQDNQEECFKQ

ZNF790

126

Q6PG37
QQNATENRFSVNFQK

TRAV38-2DV8

76

A0JD32
IQQAFEKVNQRASAT

TEX28

91

O15482
QKVNATNFQALAAEF

TCTN3

176

Q6NUS6
QTNRNDKAQEFFAKQ

WDR91

101

A4D1P6
NNTKQLRFEDVVNQS

TIAL1

186

Q01085
QAESDFQRNDQQIFK

USP40

416

Q9NVE5
QQQRAAQKLTFAFNQ

TRPM7

1676

Q96QT4
QSFKNVQQQLDATSR

TIPIN

281

Q9BVW5
DNENRQTDQFSFSIN

ZFYVE9

186

O95405
RSKQNAAEQNANQIF

TRPC4

851

Q9UBN4
SFAKQNQESAVSQQA

KIAA0586

1296

Q9BVV6
QRQQQLQFSDQSFQS

ZNF337

101

Q9Y3M9
NQNVSSFQRKFVGEV

ATP6V0A2

41

Q9Y487
QQNATENRFSVNFQK

TRAV38-1

76

A0A0B4J264
VATNLQNQNEFSFTA

UNC79

2491

Q9P2D8