Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase inhibitor activity	WDR91 ATG14	8.30e-05	8	35	2	GO:0141039
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	WDR91 ATG14	4.49e-04	18	35	2	GO:0035014
Domain	LH2	ALOX5 PKD1	4.83e-04	18	34	2	SM00308
Domain	PLAT	ALOX5 PKD1	6.61e-04	21	34	2	PF01477
Domain	PLAT	ALOX5 PKD1	6.61e-04	21	34	2	PS50095
Domain	PLAT/LH2_dom	ALOX5 PKD1	6.61e-04	21	34	2	IPR001024
Domain	-	ALOX5 PKD1	6.61e-04	21	34	2	2.60.60.20
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PPP1R16B CASP8AP2 ARHGEF4 SMC5 SYNE2	3.00e-06	225	35	5	12168954
Pubmed	BGL3 inhibits papillary thyroid carcinoma progression via regulating PTEN stability.	OTUD3 TBL2	1.47e-05	6	35	2	33543443
Pubmed	Human MMS21/NSE2 is a SUMO ligase required for DNA repair.	TSNAX SMC5	1.47e-05	6	35	2	16055714
Pubmed	The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.	WDR91 ATG14	5.38e-05	11	35	2	28404643
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK2 FOXD3	1.17e-04	16	35	2	20876279
Pubmed	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	OTUD3 BSN	1.33e-04	17	35	2	19915572
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CASP8AP2 TRMT6 BSN KIF26A ZNF646	1.78e-04	529	35	5	14621295
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	UPF2 TRRAP	3.93e-04	29	35	2	20371770
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	TSNAX NUDC TRRAP RPTN TBL2 DHX38	4.54e-04	1005	35	6	19615732
Pubmed	A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.	TRRAP MNT	5.73e-04	35	35	2	20946988
Pubmed	ZNF212 promotes genomic integrity through direct interaction with TRAIP.	CASP8AP2 CNTROB	6.41e-04	37	35	2	36594163
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	ZKSCAN2 TRRAP	6.76e-04	38	35	2	28218735
Pubmed	Association of gene polymorphisms with chronic kidney disease in Japanese individuals.	PCSK2 ALOX5	7.12e-04	39	35	2	19724895
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARHGEF4 TRRAP KIF26A CNTROB ALOX5 PKD1	7.48e-04	1105	35	6	35748872
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	CASP8AP2 TSNAX	7.87e-04	41	35	2	15561718
Pubmed	Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.	EFNB1 KIF26A	8.26e-04	42	35	2	24997765
Pubmed	Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.	TRRAP MNT	8.26e-04	42	35	2	29028833
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	TRRAP SYNE2 PKD1	8.82e-04	187	35	3	26460568
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	CASP8AP2 NUDC TRRAP CNTROB SYNE2	8.95e-04	754	35	5	35906200
Pubmed	A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.	U2AF2 ZKSCAN2	9.06e-04	44	35	2	32492419
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ATG14 SMC5 UPF2 TRRAP TBL2	9.22e-04	759	35	5	35915203
Cytoband	Ensembl 112 genes in cytogenetic band chr20p12	PCSK2 TRMT6	3.81e-03	120	35	2	chr20p12
Disease	blood chromium measurement	ARHGEF4 HS6ST3	3.88e-04	26	33	2	EFO_0007579
Disease	urate measurement	ZKSCAN2 OTUD3 HS6ST3 NUDC TBL2 DHX38	4.21e-04	895	33	6	EFO_0004531
Disease	response to anticoagulant	OTUD3 ZNF646	9.68e-04	41	33	2	GO_0061476
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	PPP1R16B ZKSCAN2 SYNE2	1.44e-03	200	33	3	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	triglycerides in LDL measurement	NUDC SYNE2	1.80e-03	56	33	2	EFO_0022320
Disease	serum alanine aminotransferase measurement	WDR91 ARHGEF4 NUDC TBL2 ALOX5	2.62e-03	869	33	5	EFO_0004735
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	NUDC SYNE2 DHX38	4.16e-03	291	33	3	EFO_0008317, EFO_0020946
Disease	alanine measurement	TBL2 ALOX5	4.18e-03	86	33	2	EFO_0009765
Disease	alkaline phosphatase measurement	WDR91 OTUD3 TBL2 DHX38 PKD1	5.08e-03	1015	33	5	EFO_0004533
Disease	myocardial infarction (is_implicated_in)	PCSK2 KCNN4	5.50e-03	99	33	2	DOID:5844 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRHQEKKEKIQRHNR	ATG14	156	Q6ZNE5
RKKLQKQAHVERRLH	ARHGEF4	76	Q9NR80
QAHIKRRHKRARKQV	CBLL2	131	Q8N7E2
RRNISDLNHPHKKQR	CASP8AP2	1836	Q9UKL3
RKESHAARRHQRKLL	KCNN4	331	O15554
LEEAKQQRKARHRSH	BSN	1016	Q9UPA5
TREVHNKLEKNRRAH	MNT	221	Q99583
RRQQRLREVQAKHKH	KIF26A	1786	Q9ULI4
HTKQLEHQRDRQKRR	HS6ST3	421	Q8IZP7
KRQEERHRHKALESR	OTUD3	356	Q5T2D3
EQDLQHRKRKHERKR	PPP1R16B	41	Q96T49
RKRHRKHTQQRAAAL	EFNB1	266	P98172
RRKHCERHIQSLQTR	CNTROB	196	Q8N137
LRRRKRFKRHQQEHL	FOXD3	231	Q9UJU5
EPKHERQHRAQIRKN	PKD1	2631	P98161
ERHHLRKELRSKNQN	UPF2	136	Q9HAU5
EARRHRLHSKDQRKR	RTL5	351	Q5HYW3
IHELKNKEIHFQRRR	SYNE2	5741	Q8WXH0
RDDQIHILKQHRRKE	ALOX5	121	P09917
HILKQHRRKELETRQ	ALOX5	126	P09917
HHNQLAQKTRREKRA	NUDC	61	Q9Y266
LKDHQRLHSENRRRR	ZNF646	1341	O15015
DYVRRREQHLHKQKQ	DHX38	346	Q92620
RKKNRETHNAVERHR	USF3	16	Q68DE3
IQLKQHISSRRHKDR	ZNF385B	361	Q569K4
KQRRQEEQRKRHLEA	TRMT6	346	Q9UJA5
RKRKHDNFPHNQRRE	TSNAX	11	Q99598
QERDKENRHRKRSHS	U2AF2	16	P26368
SRLNEHQRIHKREKS	ZNF432	246	O94892
HSGHQEQLNRKRERR	ZKSCAN2	176	Q63HK3
RRTHKDEQNHQRRDR	RPTN	731	Q6XPR3
QRRHLEEQLKEIHRK	SMC5	651	Q8IY18
SQHRQRRLQDHGKER	WDR91	326	A4D1P6
HIHDNNKNRNSKLRR	TRRAP	1846	Q9Y4A5
RIRKEKPQQHNFTHR	TBL2	66	Q9Y4P3
KAKRRRSLHHKQQLE	PCSK2	76	P16519