Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5A KDM5B

1.90e-056232GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5A KDM5B

3.54e-058232GO:0032453
GeneOntologyMolecularFunctiondioxygenase activity

KDM5A KDM5B BCO1

1.89e-0498233GO:0051213
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5A KDM5B

4.71e-0428232GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5A KDM5B

5.78e-0431232GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5A KDM5B

6.16e-0432232GO:0140457
GeneOntologyMolecularFunctiondemethylase activity

KDM5A KDM5B

1.17e-0344232GO:0032451
GeneOntologyMolecularFunctionhistone modifying activity

KDM5A KDM5B PRDM6

2.23e-03229233GO:0140993
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5A KDM5B

2.53e-0365232GO:0016706
DomainLys_sp_deMease-like_dom

KDM5A KDM5B

8.69e-064232IPR013637
DomainPLU-1

KDM5A KDM5B

8.69e-064232PF08429
Domainzf-C5HC2

KDM5A KDM5B

1.45e-055232PF02928
DomainZnf_C5HC2

KDM5A KDM5B

1.45e-055232IPR004198
DomainJmjN

KDM5A KDM5B

6.49e-0510232PF02375
DomainJmjN

KDM5A KDM5B

6.49e-0510232SM00545
DomainJMJN

KDM5A KDM5B

6.49e-0510232PS51183
DomainJmjN

KDM5A KDM5B

6.49e-0510232IPR003349
DomainZinc_finger_PHD-type_CS

NFXL1 KDM5A KDM5B

6.78e-0565233IPR019786
Domain-

KDM5A KDM5B

1.51e-04152321.10.150.60
DomainARID

KDM5A KDM5B

1.51e-0415232PF01388
DomainBRIGHT

KDM5A KDM5B

1.51e-0415232SM00501
DomainARID_dom

KDM5A KDM5B

1.51e-0415232IPR001606
DomainARID

KDM5A KDM5B

1.51e-0415232PS51011
DomainPLAC

THSD4 ADAMTS14

2.45e-0419232IPR010909
DomainPLAC

THSD4 ADAMTS14

2.45e-0419232PS50900
DomainADAM_spacer1

THSD4 ADAMTS14

3.61e-0423232IPR010294
DomainADAM_spacer1

THSD4 ADAMTS14

3.61e-0423232PF05986
DomainJmjC

KDM5A KDM5B

3.94e-0424232PF02373
DomainJMJC

KDM5A KDM5B

7.04e-0432232PS51184
DomainJmjC_dom

KDM5A KDM5B

7.04e-0432232IPR003347
DomainJmjC

KDM5A KDM5B

7.48e-0433232SM00558
DomainZnf_FYVE_PHD

PIKFYVE KDM5A KDM5B

7.54e-04147233IPR011011
DomainSET_dom

PRDM6 PRDM10

1.71e-0350232IPR001214
DomainSET

PRDM6 PRDM10

1.71e-0350232PS50280
DomainTSP_1

THSD4 ADAMTS14

2.71e-0363232PF00090
DomainTSP1

THSD4 ADAMTS14

2.88e-0365232SM00209
DomainTSP1_rpt

THSD4 ADAMTS14

2.88e-0365232IPR000884
DomainTSP1

THSD4 ADAMTS14

2.88e-0365232PS50092
DomainPHD

KDM5A KDM5B

3.81e-0375232PF00628
DomainZnf_PHD-finger

KDM5A KDM5B

4.22e-0379232IPR019787
DomainPHD

KDM5A KDM5B

5.32e-0389232SM00249
DomainZnf_PHD

KDM5A KDM5B

5.56e-0391232IPR001965
DomainZF_PHD_2

KDM5A KDM5B

6.04e-0395232PS50016
DomainZF_PHD_1

KDM5A KDM5B

6.17e-0396232PS01359
Domain-

PIKFYVE KDM5A KDM5B

1.71e-024492333.30.40.10
DomainZnf_RING/FYVE/PHD

PIKFYVE KDM5A KDM5B

1.81e-02459233IPR013083
PathwayREACTOME_MATERNAL_TO_ZYGOTIC_TRANSITION_MZT

KDM5A KDM5B NOBOX

3.76e-04128163M48019
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5A KDM5B

4.82e-0429162MM14934
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 ADAMTS14

8.73e-0439162MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 ADAMTS14

8.73e-0439162M27417
Pubmed

KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.

KDM5A KDM5B

4.56e-07224234184733
Pubmed

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

KDM5A KDM5B

4.56e-07224230472020
Pubmed

Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis.

KDM5A KDM5B

4.56e-07224236509829
Pubmed

KDM5 lysine demethylases are involved in maintenance of 3'UTR length.

KDM5A KDM5B

4.56e-07224228138513
Pubmed

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

KDM5A KDM5B

1.37e-06324238230606
Pubmed

Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.

KDM5A KDM5B

1.37e-06324216645588
Pubmed

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

KDM5A KDM5B

1.37e-06324226645689
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5A KDM5B

2.74e-06424216541399
Pubmed

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.

KDM5A KDM5B

2.74e-06424222615382
Pubmed

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

KDM5A KDM5B

6.83e-06624221960634
Pubmed

DNA-binding properties of ARID family proteins.

KDM5A KDM5B

9.56e-06724215640446
Pubmed

Maternal vitamin C regulates reprogramming of DNA methylation and germline development.

AMH NOBOX

2.05e-051024231485074
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5A KDM5B

3.54e-051324224619213
Pubmed

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

KDM5A KDM5B

8.61e-052024223637629
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM5A KDM5B

9.51e-052124227626377
Pubmed

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

PRDM6 PRDM10

1.05e-042224219050759
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5A KDM5B

2.38e-043324226864203
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NFXL1 KDM5A PRDM6 PRDM10 FRMPD1

2.59e-0485724525609649
Pubmed

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.

AMH NOBOX

4.24e-044424237494420
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KDM5A KDM5B

4.24e-044424224183668
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM5A KDM5B

5.26e-044924234368113
GeneFamilyAT-rich interaction domain containing

KDM5A KDM5B

8.67e-0515172418
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM6 PRDM10

1.12e-04171721197
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5A KDM5B

2.27e-0424172485
GeneFamilyPHD finger proteins

KDM5A KDM5B

3.17e-039017288
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NFXL1 PRDM10 RNGTT

9.94e-05169243b66ffc2b2b6bfcc3a6e639d9d31d3de95f4a94e1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STRADB ADAMTS14 NOBOX

9.94e-051692437c994653b0d629dfb046755d6b678452de0a15d2
ToppCellCOVID-19_Moderate-RBC|World / disease group, cell group and cell class

STRADB FKBP8 C9orf40

1.18e-04179243932fa98c0981ef8ef1e4945cdd4ae8c6c0858251
ToppCellCOVID-19_Moderate-RBC|COVID-19_Moderate / disease group, cell group and cell class

STRADB FKBP8 C9orf40

1.26e-041832430dc337cd3f4f7964b0a268139c7ddc0f58b6a279
ToppCellCOVID-19_Severe-RBC|COVID-19_Severe / disease group, cell group and cell class

STRADB FKBP8 C9orf40

1.28e-04184243bb58244194ffb5558fbe85c5f856888210dcb1e8
ToppCellCOVID-19_Severe-RBC|World / disease group, cell group and cell class

STRADB FKBP8 C9orf40

1.30e-0418524396b7058b1b282134970aa9e75285760a9f94a8b5
ToppCellPCW_10-12-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

STRADB FKBP8 C9orf40

1.32e-0418624340acd9b4e9b3c1d1527bd4ba17ae830ff18d6e9d
ToppCellPCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

STRADB FKBP8 C9orf40

1.32e-0418624334ed60e846fd83fab3e28dc9e278bcc4b092a9f0
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid-late_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STRADB FKBP8 C9orf40

1.49e-0419424323b06707d21306b4483d64cb350b86aef352ce38
ToppCell10x3'2.3-week_17-19-Hematopoietic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STRADB FKBP8 C9orf40

1.54e-041962432aeb792e7685e33e3543a6974be790980a41ed8c
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STRADB FKBP8 C9orf40

1.56e-04197243b71da7f2fd8d526fb6e5d57e60fc08acdd8dbefb
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

STRADB FKBP8 FRMPD1

1.61e-04199243565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

STRADB FKBP8 FRMPD1

1.61e-041992436c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

STRADB FKBP8 FRMPD1

1.61e-04199243284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AMH BCO1

2.21e-0441242b1e70962de91a747ec718a3fad4247fd0cb7d9a8
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AMH BCO1

2.21e-044124216dbb13baa47c4db80ddd83ac36aad6c43b5461a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SHISA8 FRMPD1

7.39e-04752425edf024797a6dd9cbf9916a503194e29e0152d6c
ToppCellClub-club-6|World / Class top

QSOX1 AMH

7.79e-04772423653cf20b1b312578a54ffd33e75a8b92874f9bf
ToppCell10x3'2.3-week_12-13-Hematopoietic-erythroid-late_erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

STRADB FKBP8

1.11e-03922423292898c81580e33c82f91b949a86bf4b5297781
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

1.61e-0311124284b7d4fe5839f649bc4246738d620c9cee3c4cf7
ToppCellBronchial-10x5prime-Hematologic-Erythrocyte-Erythrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AMH STRADB

2.06e-0312624212f3d0f60db462f2a9799b3a06005bc871670760
ToppCellBronchial-10x5prime-Hematologic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AMH STRADB

2.06e-03126242b6482ef18e6d9e12ba4810ce7845f9f991cb95bc
ToppCellBronchial-10x5prime-Hematologic-Erythrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AMH STRADB

2.06e-0312624265c7c0e4cfb5ac58d80b4034d42e9f662116e0d3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c10-IFNG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

XKR6 SHISA8

2.06e-03126242d19382597ce5c6546731ac1fd33c7dcb7916b2ea
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PRDM6 ADAMTS14

2.09e-031272428c972ea21797ee46d6c67e91cfd2e2e2ce016248
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3|Hippocampus / BrainAtlas - Mouse McCarroll V32

THSD4 ADAMTS14

2.09e-031272429bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Col15a1_Pde1a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

2.19e-0313024256b9c3325e011f1dbaf9efc71bd6e1af4f96fda6
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

STRADB FKBP8

2.23e-03131242537a79ea2b5d6b3dc0444570b1acbceda59b0d7c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Col15a1_Pde1a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

2.33e-03134242d63fff23040eada31bc35ba1e05b7c6a663e0037
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

STRADB FKBP8

2.40e-0313624294eb78a4b8da307c07c2c4f05b8a14424f887579
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ADRA1B SHISA8

2.50e-03139242408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XKR6 SHISA8

2.50e-03139242693ca81f5831b63fe6148ac755631e09f67d0ebf
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1B ADAMTS14

2.54e-031402427ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1B ADAMTS14

2.54e-031402421a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCell10x5'v1-week_12-13-Hematopoietic-erythroid-late_erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

STRADB FKBP8

2.68e-03144242ca365380ccf5e60d2e3f6272059ff0531759612d
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Erythrocyte|Erythro-cells / Lineage, cell class and subclass

STRADB FKBP8

2.68e-031442427fbedc65314cfb06bcc527d794b5de7858f7c5ec
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

THSD4 NFXL1

2.75e-03146242159dd157a74f3c27dc1a1dcbbf0ed8f9462cac9e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

2.75e-0314624247368f981180ca6a8c81a50f7f9430f12456f609
ToppCellAdult-Mesenchymal-chondrocyte-D122|Adult / Lineage, Cell type, age group and donor

PRDM6 ADRA1B

2.83e-0314824281a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SHISA8 FRMPD1

2.87e-031492421e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCellfacs-Marrow-Granulocytes-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS14 BCO1

2.90e-03150242a3a4710820a244116a26204f40e7113a1e7236c5
ToppCellfacs-Marrow-Granulocytes-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS14 BCO1

2.90e-0315024213dcd519dacf08d5852aa3e029e0a3308de07321
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NOBOX BCO1

2.94e-0315124216fc903fc71e25717b9908416f0bcd29c0a65a61
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

THSD4 PRDM6

3.02e-03153242151c469b26f9adf04dd6f117f03bef760cc3d45d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

XKR6 FRMPD1

3.02e-0315324279c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XKR6 ADAMTS14

3.06e-0315424275eac6970259a6916fcfa6d3400509cfa2d98d9d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.10e-031552423b8def9e8f66511736ea37f259511f7c8b7743af
ToppCellfacs-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFXL1 BCO1

3.14e-031562423f0b9e35d4da85c90759b930052e5b9c3cde9b15
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.14e-03156242896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCellfacs-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFXL1 BCO1

3.14e-0315624269e6e8810d1738a66c9821910f41498931cf30cc
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PRDM6 BCO1

3.21e-03158242e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

XKR6 FRMPD1

3.25e-0315924250d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

THSD4 XKR6

3.25e-0315924224f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHISA8 FRMPD1

3.29e-031602422d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHISA8 FRMPD1

3.29e-031602428bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NFXL1 PRDM10

3.29e-031602428bb873704895c3b35bba8af78fedbabf7df42e71
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

PRDM6 ADRA1B

3.29e-03160242fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

PIKFYVE SHISA8

3.29e-031602426722934e153b72039c3c4308557d0ef879a30638
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.34e-031612423b5d7a3dab479c6959a428f3954dedd989900276
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.34e-03161242be77e99faf653480c166305df3a4e93db76f0dcb
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMH ADAMTS14

3.34e-031612423f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

THSD4 XKR6

3.38e-031622422259e9536147e9cdee772e3a30ba7d104573262c
ToppCell10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

PIKFYVE SHISA8

3.38e-0316224244832055b11a789e320c802aadb345e065defc8f
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM10 ADAMTS14

3.42e-03163242eaed783eecd07aafa5af844b63c9d816b4da99e4
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM10 ADAMTS14

3.42e-03163242a763c1632d6465a1e753bdc8eadaf819d2b09e5e
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

XKR6 SHISA8

3.46e-0316424269b6566fb88c7449b7ab9056b57508cb6a1aa2af
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD4 SHISA8

3.46e-031642424a4c32d242db97216cb345e59865c2c826c8b9f2
ToppCellfacs-BAT-Fat-3m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS14 C9orf40

3.46e-03164242cbdb7e893cb3959b9920c0c7c535ace03a5f4986
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.50e-03165242c6b23013d77fa9aa967b76e451c8e42b0a657c30
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGAP6 ADRA1B

3.50e-031652421703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCellCOVID-19_Severe-PLT_1|World / Disease Group and Platelet Clusters

STRADB SHISA8

3.54e-031662422c89b45eb20e24aae165f1a8e61680d3b63210ac
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD4 SHISA8

3.54e-03166242688e3c01ffcec01eb7027df6f3bde8fecfb50479
ToppCell10x3'2.3-week_14-16-Hematopoietic-erythroid-late_erythroid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

STRADB FKBP8

3.54e-03166242b4e5466a33578103d197cf67f37e7ec88e09281f
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

THSD4 XKR6

3.54e-0316624289e2b8453180983533faccb4275867861876d7ee
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic|TCGA-Mesothelium / Sample_Type by Project: Shred V9

THSD4 C9orf40

3.58e-031672429062577a4b7902c9a888d706589d1b05221c0fa8
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

THSD4 XKR6

3.58e-031672425af9127bae05768a5164d5708a4ad37edca99324
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THSD4 PGAP6

3.58e-03167242d1a13d6ada572d8ddb2da95e6e122d2b705fad7f
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.62e-03168242f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NFXL1 PRDM10

3.62e-031682422fb2d916eb5000a637240d38e47a9b4f61f9f83f
ToppCell343B-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KDM5A FRMPD1

3.67e-03169242632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCellControl-Hematopoietic_Meg-Ery-Erythroid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRADB FKBP8

3.67e-03169242df1fc1477bbbb285063b9b122b1ac84c87fd7fa8
ToppCellControl-Hematopoietic_Meg-Ery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRADB FKBP8

3.67e-03169242c2e2a7b89fe4a64d79efafdec037c4104f433061
ToppCellControl-Hematopoietic_Meg-Ery-Erythroid-Erythroid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRADB FKBP8

3.67e-0316924292986559aa4a744e8b0487b0ae035cfb1fbf9890
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1B SHISA8

3.71e-0317024245584bd9953257dd28c06ffbbfe4395ce7b1b88d
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5A PRDM10

3.71e-031702423ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythroid_lineage_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

STRADB FKBP8

3.71e-03170242288014dedda8babc51fe08e48a55e68d83e1b1d2
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFXL1 PRDM6

3.71e-03170242b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1B SHISA8

3.71e-0317024228e22f9ef58423acc0fb8de1aff958b116dd33e9
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1B SHISA8

3.71e-0317024236dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-hematopoietic_progenitor-erythroid_progenitor_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

STRADB FKBP8

3.71e-0317024274bb46826141bd1e80b4ce16e6bbfc770bd427d3
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-hematopoietic_progenitor|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

STRADB FKBP8

3.71e-031702426592ebe204b43b81c6b6da99e05da72c0983b3fa
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NFXL1 DCAF16

3.75e-031712425e93c76ee60f9d0590ebb140812653a5e1369417
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.75e-03171242f9ae7964a3740f559431125c17c660549798cccc
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.75e-031712425efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCelldroplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGAP6 C9orf40

3.75e-03171242e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 PRDM6

3.75e-031712424ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Red_blood_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STRADB FKBP8

3.79e-031722428ccc3459dbdf103c631aa2a0defb8790c06ad6c1
ToppCell356C-Lymphocytic-ILC-ILC-2|ILC / Donor, Lineage, Cell class and subclass (all cells)

PGAP6 C9orf40

3.79e-031722424977e1f4deae781750e27a8054deccd336cfb74a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1B SHISA8

3.79e-031722427e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMPD1 ADAMTS14

3.79e-031722423a37569a5902f3c65ff8d3912421309a8c82ee9b
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5A KDM5B

3.48e-064232DOID:0060809 (implicated_via_orthology)
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5A KDM5B

6.93e-0516232DOID:0050888 (implicated_via_orthology)
DiseasePeriodontal Pocket

XKR6 ADAMTS14

1.72e-0425232EFO_1001393
Diseasealcohol use disorder (implicated_via_orthology)

KDM5A KDM5B ADRA1B

4.57e-04195233DOID:1574 (implicated_via_orthology)
Diseaseresponse to simvastatin, myopathy

XKR6 RNGTT

4.68e-0441232EFO_0004145, GO_1903491
Diseasepulse pressure measurement

THSD4 KDM5A QSOX1 AMH PRDM6 ADRA1B

5.50e-041392236EFO_0005763
Diseaseintellectual disability (implicated_via_orthology)

KDM5A KDM5B

1.56e-0375232DOID:1059 (implicated_via_orthology)
Diseasesmoking status measurement, chronic obstructive pulmonary disease

THSD4 ATF6B

2.14e-0388232EFO_0000341, EFO_0006527
DiseaseR-6-hydroxywarfarin to R-warfarin ratio measurement

THSD4 BCO1

3.08e-03106232EFO_0803333
DiseaseDrug Use Disorders

THSD4 QSOX1

3.61e-03115232C0013222
DiseaseDrug Dependence

THSD4 QSOX1

3.61e-03115232C1510472
DiseaseDrug habituation

THSD4 QSOX1

3.61e-03115232C0013170
DiseaseSubstance Dependence

THSD4 QSOX1

3.61e-03115232C0038580
DiseaseSubstance Use Disorders

THSD4 QSOX1

3.61e-03115232C0038586
DiseaseSubstance-Related Disorders

THSD4 QSOX1

3.61e-03115232C0236969
DiseaseDrug abuse

THSD4 QSOX1

3.61e-03115232C0013146
DiseaseOrganic Mental Disorders, Substance-Induced

THSD4 QSOX1

3.61e-03115232C0029231
DiseasePrescription Drug Abuse

THSD4 QSOX1

3.61e-03115232C4316881
DiseaseSubstance abuse problem

THSD4 QSOX1

3.67e-03116232C0740858
Diseasecarotid artery intima media thickness

THSD4 PRDM10 XKR6

4.97e-03450233EFO_0007117
Diseaseascending aortic diameter

THSD4 PRDM6

5.30e-03140232EFO_0021787

Protein segments in the cluster

PeptideGeneStartEntry
PKPAWEEPPPERALE

CDRT15L2

106

A8MXV6
PPPVELCAFPEWKAP

ADRA1B

436

P35368
SHCVPKLEPIPEWPP

DCAF16

101

Q9NXF7
LLDDPFDPAWPQPPE

ADAMTS14

456

Q8WXS8
WPPACPPLEPAKLEE

QSOX1

161

O00391
WSDPCLPELPFPGPF

NOBOX

596

O60393
EEAPPPPLLPDWCFE

RNGTT

181

O60942
CGKVEDPPLDPWLVP

NFXL1

236

Q6ZNB6
FLPPPECPVFEPSWE

KDM5B

26

Q9UGL1
PPPDWQPPFACDVDK

KDM5B

66

Q9UGL1
EDLDWPPGSPQEPLC

AMH

41

P03971
LLPPPDQPAEPWACS

PGAP6

736

Q9HCN3
DLDDWEPDPPRPFDP

PRDM10

156

Q9NQV6
EPDPPRPFDPHDLWC

PRDM10

161

Q9NQV6
PPECPVFEPSWEEFT

KDM5A

16

P29375
AAPPPELPEWLRDLP

PRDM6

231

Q9NQX0
IPWDPDIPPESLPCD

PIKFYVE

911

Q9Y2I7
EPEPAPAPAPEEWLD

FKBP8

81

Q14318
EWVCFNPEPSLPEPL

FRMPD1

1246

Q5SYB0
LCDFAEQPPPPPLWI

C9orf40

21

Q8IXQ3
DLPAPLDACPWAPPV

SHISA8

301

B8ZZ34
DDCWPAEPLFVPAPG

BCO1

451

Q9HAY6
PSEPPWELLPIFPDL

ATF6B

71

Q99941
EPPPPQVERPWLDCL

XKR6

116

Q5GH73
PPVLPWTEPECDFPD

STRADB

396

Q9C0K7
PEEEPCNIFPCPAFW

THSD4

666

Q6ZMP0