Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone modifying activity

SETBP1 EYA1

1.91e-0322962GO:0140993
GeneOntologyMolecularFunctionmRNA binding

YTHDF1 SYNCRIP

1.65e-0269462GO:0003729
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

SFSWAP YTHDF1 SYNCRIP

1.88e-0444363GO:1903311
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

SFSWAP SYNCRIP

4.56e-0411562GO:1903312
GeneOntologyBiologicalProcesspositive regulation of translation

YTHDF1 SYNCRIP

7.83e-0415162GO:0045727
GeneOntologyBiologicalProcessmRNA destabilization

YTHDF1 SYNCRIP

1.45e-0320662GO:0061157
GeneOntologyBiologicalProcessRNA destabilization

YTHDF1 SYNCRIP

1.52e-0321162GO:0050779
GeneOntologyBiologicalProcesspositive regulation of mRNA catabolic process

YTHDF1 SYNCRIP

1.52e-0321162GO:0061014
GeneOntologyBiologicalProcessmRNA metabolic process

SFSWAP YTHDF1 SYNCRIP

1.58e-0391763GO:0016071
GeneOntologyBiologicalProcesspositive regulation of mRNA metabolic process

YTHDF1 SYNCRIP

2.28e-0325962GO:1903313
GeneOntologyBiologicalProcessregulation of mRNA stability

YTHDF1 SYNCRIP

2.89e-0329262GO:0043488
GeneOntologyBiologicalProcessregulation of RNA stability

YTHDF1 SYNCRIP

3.20e-0330862GO:0043487
GeneOntologyBiologicalProcessregulation of mRNA catabolic process

YTHDF1 SYNCRIP

3.22e-0330962GO:0061013
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

SFSWAP SYNCRIP

4.30e-0335862GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

SFSWAP SYNCRIP

4.30e-0335862GO:0000377
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

SFSWAP SYNCRIP

4.40e-0336262GO:0000375
GeneOntologyBiologicalProcessmRNA catabolic process

YTHDF1 SYNCRIP

4.66e-0337362GO:0006402
GeneOntologyBiologicalProcessRNA catabolic process

YTHDF1 SYNCRIP

6.21e-0343262GO:0006401
GeneOntologyBiologicalProcessnucleic acid catabolic process

YTHDF1 SYNCRIP

7.13e-0346462GO:0141188
GeneOntologyBiologicalProcessregulation of translation

YTHDF1 SYNCRIP

8.06e-0349462GO:0006417
GeneOntologyBiologicalProcessRNA splicing

SFSWAP SYNCRIP

8.31e-0350262GO:0008380
HumanPhenoAbnormality of the middle ear ossicles

SETBP1 EYA1

2.31e-052522HP:0004452
HumanPhenoUreteral stenosis

SETBP1 EYA1

4.07e-053322HP:0000071
HumanPhenoAbnormal cochlea morphology

SETBP1 EYA1

4.59e-053522HP:0000375
HumanPhenoUreteral obstruction

SETBP1 EYA1

5.71e-053922HP:0006000
HumanPhenoAbnormal inner ear morphology

SETBP1 EYA1

2.50e-048122HP:0011390
HumanPhenoLacrimation abnormality

SETBP1 EYA1

2.88e-048722HP:0000632
HumanPhenoAbnormal clavicle morphology

SETBP1 EYA1

5.14e-0411622HP:0000889
MousePhenohearing/vestibular/ear phenotype

SFSWAP EYA1 SYNCRIP

2.45e-0390553MP:0005377
MousePhenoabnormal inner ear morphology

SFSWAP EYA1

4.48e-0330352MP:0000026
MousePhenoabnormal ear morphology

SFSWAP EYA1

1.05e-0247052MP:0002102
PathwayWP_MRNA_PROCESSING

SFSWAP SYNCRIP

5.87e-0345142MM15946
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SFSWAP YTHDF1 LENG8 SYNCRIP

8.08e-069546436373674
Pubmed

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.

EYA1 SYNCRIP

1.31e-05336216870172
Pubmed

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

YTHDF1 SYNCRIP

2.23e-05436226487511
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

YTHDF1 LENG8 SYNCRIP

4.52e-054626331138677
Pubmed

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.

EYA1 SYNCRIP

9.87e-05906233087562
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

SFSWAP YTHDF1 SYNCRIP

1.64e-047136329802200
InteractionALG13 interactions

YTHDF1 LENG8 SYNCRIP

1.44e-0518363int:ALG13
InteractionZNF677 interactions

SFSWAP LENG8

2.58e-052762int:ZNF677
InteractionPURG interactions

YTHDF1 LENG8 SYNCRIP

2.61e-0522363int:PURG
InteractionHDLBP interactions

SFSWAP YTHDF1 LENG8 SYNCRIP

4.51e-0585564int:HDLBP
InteractionSMG7 interactions

YTHDF1 LENG8 SYNCRIP

7.58e-0531963int:SMG7
InteractionSMC5 interactions

SFSWAP YTHDF1 LENG8 SYNCRIP

8.34e-05100064int:SMC5
InteractionZNF34 interactions

YTHDF1 LENG8

8.63e-054962int:ZNF34
InteractionKLF16 interactions

YTHDF1 LENG8 SYNCRIP

1.78e-0442563int:KLF16
InteractionSECISBP2 interactions

YTHDF1 SYNCRIP

2.20e-047862int:SECISBP2
InteractionR3HDM1 interactions

YTHDF1 SYNCRIP

2.55e-048462int:R3HDM1
InteractionSNRPA interactions

YTHDF1 LENG8 SYNCRIP

2.58e-0448263int:SNRPA
InteractionMYCN interactions

SFSWAP YTHDF1 LENG8 SYNCRIP

2.88e-04137364int:MYCN
InteractionIGF2BP1 interactions

SFSWAP YTHDF1 SYNCRIP

3.01e-0450863int:IGF2BP1
InteractionDMRTB1 interactions

YTHDF1 LENG8

3.19e-049462int:DMRTB1
InteractionPPIL3 interactions

YTHDF1 SYNCRIP

3.61e-0410062int:PPIL3
InteractionCCDC59 interactions

LENG8 SYNCRIP

4.53e-0411262int:CCDC59
InteractionHMGXB4 interactions

LENG8 SYNCRIP

4.61e-0411362int:HMGXB4
InteractionSMN2 interactions

LENG8 SYNCRIP

4.69e-0411462int:SMN2
InteractionFBL interactions

YTHDF1 LENG8 SYNCRIP

5.91e-0463963int:FBL
InteractionMKI67 interactions

YTHDF1 LENG8 SYNCRIP

6.15e-0464863int:MKI67
InteractionDAZL interactions

YTHDF1 SYNCRIP

7.57e-0414562int:DAZL
InteractionCPEB1 interactions

YTHDF1 SYNCRIP

7.67e-0414662int:CPEB1
InteractionSYT2 interactions

LENG8 SYNCRIP

8.09e-0415062int:SYT2
InteractionPER2 interactions

LENG8 SYNCRIP

8.42e-0415362int:PER2
InteractionCPEB4 interactions

YTHDF1 SYNCRIP

8.75e-0415662int:CPEB4
InteractionDOT1L interactions

SFSWAP YTHDF1 SYNCRIP

1.17e-0380763int:DOT1L
InteractionPIP interactions

YTHDF1 EYA1

1.18e-0318162int:PIP
InteractionAGO1 interactions

YTHDF1 SYNCRIP

1.20e-0318362int:AGO1
InteractionQKI interactions

YTHDF1 SYNCRIP

1.29e-0319062int:QKI
InteractionFAM120C interactions

YTHDF1 SYNCRIP

1.31e-0319162int:FAM120C
InteractionMSX2 interactions

YTHDF1 LENG8

1.36e-0319562int:MSX2
InteractionZC3H18 interactions

SFSWAP LENG8 SYNCRIP

1.49e-0387763int:ZC3H18
InteractionRBMS1 interactions

YTHDF1 SYNCRIP

1.53e-0320762int:RBMS1
InteractionCAND1 interactions

SFSWAP LENG8 SYNCRIP

1.57e-0389463int:CAND1
InteractionLARP4 interactions

YTHDF1 SYNCRIP

1.58e-0321062int:LARP4
InteractionZFP36L2 interactions

SETBP1 SYNCRIP

1.59e-0321162int:ZFP36L2
InteractionTDRD3 interactions

YTHDF1 SYNCRIP

1.61e-0321262int:TDRD3
InteractionNR4A1 interactions

EYA1 SYNCRIP

1.61e-0321262int:NR4A1
InteractionZC3H7A interactions

YTHDF1 SYNCRIP

1.65e-0321562int:ZC3H7A
InteractionDNAJC8 interactions

YTHDF1 SYNCRIP

1.89e-0323062int:DNAJC8
InteractionTNIP2 interactions

SFSWAP YTHDF1 SYNCRIP

1.89e-0395263int:TNIP2
InteractionOTUD4 interactions

YTHDF1 SYNCRIP

1.99e-0323662int:OTUD4
InteractionLARP4B interactions

YTHDF1 SYNCRIP

2.05e-0324062int:LARP4B
InteractionSNRNP70 interactions

SFSWAP YTHDF1 SYNCRIP

2.08e-0398463int:SNRNP70
InteractionYTHDF3 interactions

YTHDF1 SYNCRIP

2.16e-0324662int:YTHDF3
InteractionLASP1 interactions

YTHDF1 LENG8

2.17e-0324762int:LASP1
InteractionMEN1 interactions

YTHDF1 LENG8 SETBP1

2.36e-03102963int:MEN1
InteractionLSM14A interactions

YTHDF1 SYNCRIP

2.40e-0326062int:LSM14A
InteractionPRRC2B interactions

YTHDF1 SYNCRIP

2.50e-0326562int:PRRC2B
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN

YTHDF1 LENG8 SYNCRIP

8.57e-0543263M41149
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EYA1 SYNCRIP

8.35e-051076260b272f5c89bea8a2714f870e18b7ac89a4a4bf6
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EYA1 SYNCRIP

8.35e-0510762c41bc8810df67158f0ae9f6015c965a8ebd96965
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EYA1 SYNCRIP

1.71e-041536288ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

EYA1 SYNCRIP

1.71e-0415362553dff9688a1996d8f4ba16e60c683593d781389
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SETBP1 EYA1

2.18e-0417362c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SETBP1 EYA1

2.83e-04197621e915957ea6a4550ecb9d6ee4b232aa5800faf20
DiseaseCraniofacial Abnormalities

SETBP1 EYA1

4.11e-0415662C0376634
DiseaseIschemic stroke

SETBP1 EYA1

1.75e-0332462HP_0002140
Diseasecreatinine measurement

SETBP1 EYA1

1.56e-0299562EFO_0004518
Diseasereticulocyte count

SETBP1 EYA1

1.71e-02104562EFO_0007986
Diseasereticulocyte measurement

SETBP1 EYA1

1.73e-02105362EFO_0010700
Diseasewaist-hip ratio

SETBP1 EYA1

2.31e-02122662EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
AYPYSYYYPMSMYQS

LENG8

96

Q96PV6
YYYPMSMYQSYGSPS

LENG8

101

Q96PV6
QMYDDYYYYGPPHMP

SYNCRIP

426

O60506
YAQYYNSSPYPAHYM

EYA1

226

Q99502
MYYSYYMLPDGTYCL

SFSWAP

366

Q12872
SYYAPYGMPYTSMPM

SETBP1

1046

Q9Y6X0
NSYPSMSDPYLSSYY

YTHDF1

46

Q9BYJ9