Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone deacetylase activity

HDAC9 HDAC5 HDAC4

1.57e-0424883GO:0004407
GeneOntologyMolecularFunctionprotein lysine deacetylase activity

HDAC9 HDAC5 HDAC4

1.77e-0425883GO:0033558
GeneOntologyMolecularFunctionurea channel activity

AQP7P3 AQP7

1.90e-045882GO:0015265
GeneOntologyMolecularFunctionglycerol channel activity

AQP7P3 AQP7

3.97e-047882GO:0015254
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

HDAC9 ZBP1 HDAC5 HDAC4 OPLAH

4.70e-04146885GO:0016810
GeneOntologyMolecularFunctionurea transmembrane transporter activity

AQP7P3 AQP7

6.78e-049882GO:0015204
GeneOntologyMolecularFunctionglycerol transmembrane transporter activity

AQP7P3 AQP7

6.78e-049882GO:0015168
GeneOntologyMolecularFunctiondeacetylase activity

HDAC9 HDAC5 HDAC4

7.26e-0440883GO:0019213
GeneOntologyBiologicalProcessregulation of skeletal muscle fiber differentiation

HDAC9 HDAC5 HDAC4

2.51e-067873GO:1902809
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

HDAC9 NRDE2 HDAC5 HDAC4 UBR5 MACROH2A2 TASOR

2.42e-05203877GO:0045814
GeneOntologyBiologicalProcessregulation of skeletal muscle fiber development

HDAC9 HDAC5 HDAC4

2.55e-0514873GO:0048742
GeneOntologyBiologicalProcessskeletal muscle fiber differentiation

HDAC9 HDAC5 HDAC4

3.90e-0516873GO:0098528
GeneOntologyBiologicalProcessosteoblast development

HDAC5 HDAC4 RUNX2

6.69e-0519873GO:0002076
GeneOntologyBiologicalProcessneuroligin clustering involved in postsynaptic membrane assembly

MAGI2 NRXN2

1.05e-044872GO:0097118
MousePhenodecreased urine glycerol level

AQP7P3 AQP7

2.69e-052732MP:0030781
DomainHist_deacetylase_Gln_rich_N

HDAC9 HDAC5 HDAC4

9.10e-083853IPR024643
DomainHDAC4_Gln

HDAC9 HDAC5 HDAC4

9.10e-083853PF12203
DomainHistone_deAcase_II_euk

HDAC9 HDAC5 HDAC4

3.63e-074853IPR017320
DomainZnF_C2HC

FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10

5.04e-0655855SM00343
DomainZnf_CCHC

FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10

5.04e-0655855IPR001878
DomainHist_deacetyl

HDAC9 HDAC5 HDAC4

1.46e-0511853PF00850
DomainHis_deacetylse_dom

HDAC9 HDAC5 HDAC4

1.46e-0511853IPR023801
Domain-

HDAC9 HDAC5 HDAC4

1.46e-05118533.40.800.20
DomainHis_deacetylse

HDAC9 HDAC5 HDAC4

1.46e-0511853IPR000286
PathwayPID_HDAC_CLASSI_PATHWAY

HDAC9 HDAC5 HDAC4 SSPOP

1.00e-0466524M101
PathwayREACTOME_RUNX2_REGULATES_CHONDROCYTE_MATURATION

HDAC4 RUNX2

1.33e-045522M27804
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

HDAC9 HDAC5 HDAC4

1.45e-0428523M6177
PathwayWP_ETHANOL_EFFECTS_ON_HISTONE_MODIFICATIONS

HDAC9 HDAC5 HDAC4

1.98e-0431523M39714
PathwayREACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT

ABL1 HDAC4 RUNX2

1.98e-0431523M27805
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

HDAC9 HDAC5 HDAC4

2.18e-0432523M39521
PathwayPID_HDAC_CLASSII_PATHWAY

HDAC9 HDAC5 HDAC4

2.61e-0434523M30
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

HDAC9 HDAC5 HDAC4 GATA4

4.78e-0499524MM15905
PathwayWP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY

HDAC9 HDAC5 HDAC4 GATA4

5.77e-04104524M39625
PathwayBIOCARTA_RANBP2_PATHWAY

HDAC9 HDAC4

7.19e-0411522M22027
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

HDAC9 HDAC5 HDAC4

7.28e-0448523M611
Pubmed

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.

FAM90A17 FAM90A19 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

1.67e-152591817684299
Pubmed

Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.

FAM90A17 FAM90A19 FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10

1.57e-132391718602769
Pubmed

Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases.

HDAC9 HDAC5 HDAC4

1.73e-08391323297420
Pubmed

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.

HDAC9 HDAC5 HDAC4 RUNX2

4.30e-081491415537544
Pubmed

PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.

HDAC5 HDAC4 RUNX2

6.92e-08491330843886
Pubmed

Class IIa histone deacetylases: conducting development and differentiation.

HDAC9 HDAC5 HDAC4

6.92e-08491319412888
Pubmed

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.

HDAC9 HDAC5 HDAC4

6.92e-08491310748098
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MAGI2 HDAC5 UBR5 ZSWIM5 ERC1 SEC16A LRRC7 ARHGEF17 CSMD3 PCNT

1.19e-07407911012693553
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

KMT2C SULF2 HDAC5 NRXN2 UBR5 ERC1 SEC16A PCNT

1.45e-0722591812168954
Pubmed

Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.

HDAC9 HDAC5 HDAC4

1.73e-07591315194749
Pubmed

Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor.

HDAC9 HDAC5 HDAC4

1.73e-07591319893013
Pubmed

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4.

HDAC9 HDAC5 HDAC4

1.73e-07591318332106
Pubmed

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

FAM90A17 FAM90A19 PXYLP1 FAM90A7 FAM90A9 FAM90A8 FAM90A10

2.65e-0716491722967998
Pubmed

Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation.

HDAC9 HDAC5 HDAC4

3.45e-07691316356933
Pubmed

Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.

HDAC9 HDAC5 HDAC4

6.02e-07791311022042
Pubmed

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

HDAC5 HDAC4 RUNX2

6.02e-07791315990875
Pubmed

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.

HDAC9 HDAC5 HDAC4

9.61e-07891317786239
Pubmed

Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.

HDAC9 HDAC5 HDAC4

9.61e-07891312242305
Pubmed

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.

HDAC9 HDAC5 HDAC4

1.44e-06991311466315
Pubmed

Bone morphogenetic protein-2 stimulates Runx2 acetylation.

HDAC5 HDAC4 RUNX2

1.44e-06991316613856
Pubmed

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

HDAC9 HDAC5 HDAC4

1.44e-06991315367668
Pubmed

The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.

HDAC9 HDAC5 HDAC4

1.44e-06991316260608
Pubmed

Class II histone deacetylases: versatile regulators.

HDAC9 HDAC5 HDAC4

2.05e-061091312711221
Pubmed

Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.

HDAC9 HDAC5 HDAC4

2.05e-061091328028172
Pubmed

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.

HDAC9 HDAC5 HDAC4

2.82e-061191331223056
Pubmed

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

ABL1 HDAC5 HDAC4

2.82e-061191322649097
Pubmed

Kinase signalling in excitatory neurons regulates sleep quantity and depth.

HDAC9 HDAC5 HDAC4

3.75e-061291336477539
Pubmed

Alternative splice variants encoding unstable protein domains exist in the human brain.

FAT2 HDAC5 NRXN2

4.86e-061391315491607
Pubmed

Histone deacetylase expression patterns in developing murine optic nerve.

HDAC9 HDAC5 HDAC4

6.18e-061491325011550
Pubmed

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.

HDAC9 HDAC5 HDAC4

6.18e-061491315601857
Pubmed

Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.

HDAC9 HDAC5 HDAC4

6.18e-061491315964851
Pubmed

Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9.

HDAC9 HDAC5 HDAC4

6.18e-061491321953612
Pubmed

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.

HDAC5 HDAC4

6.77e-06291229472387
Pubmed

Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.

AQP7P3 AQP7

6.77e-06291223290745
Pubmed

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

HDAC5 HDAC4

6.77e-06291227626651
Pubmed

Over-expression of AQP7 contributes to improve insulin resistance in adipocytes.

AQP7P3 AQP7

6.77e-06291222877989
Pubmed

The epigenetic reader Brd4 is required for osteoblast differentiation.

BRD4 RUNX2

6.77e-06291231868237
Pubmed

Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.

AQP7P3 AQP7

6.77e-06291232631905
Pubmed

Ratjadone C-mediated nuclear accumulation of HDAC4: implications on Runx2-induced osteoblast differentiation of C3H10T1/2 mesenchymal stem cells.

HDAC4 RUNX2

6.77e-06291225854767
Pubmed

Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.

AQP7P3 AQP7

6.77e-06291211457862
Pubmed

Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice.

AQP7P3 AQP7

6.77e-06291237691043
Pubmed

Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.

AQP7P3 AQP7

6.77e-06291237879294
Pubmed

Aquaporin7 expression during perinatal development of mouse brain.

AQP7P3 AQP7

6.77e-06291217052846
Pubmed

Prolonged Starvation Causes Up-Regulation of AQP1 in Adipose Tissue Capillaries of AQP7 Knock-Out Mice.

AQP7P3 AQP7

6.77e-06291227455244
Pubmed

Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.

AQP7P3 AQP7

6.77e-06291221968069
Pubmed

Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling.

HDAC5 HDAC4

6.77e-06291217975112
Pubmed

Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice.

AQP7P3 AQP7

6.77e-06291217123523
Pubmed

Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.

AQP7P3 AQP7

6.77e-06291211972053
Pubmed

Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity.

HDAC5 HDAC4

6.77e-06291223364788
Pubmed

Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.

AQP7P3 AQP7

6.77e-06291215591341
Pubmed

Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.

AQP7P3 AQP7

6.77e-06291237432580
Pubmed

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.

HDAC5 HDAC4

6.77e-06291231375688
Pubmed

Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice.

HDAC5 HDAC4

6.77e-06291222403301
Pubmed

Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.

AQP7P3 AQP7

6.77e-06291217576812
Pubmed

Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.

AQP7P3 AQP7

6.77e-06291215746100
Pubmed

Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation.

AQP7P3 AQP7

6.77e-06291226634435
Pubmed

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.

BRD4 GATA4

6.77e-06291233094644
Pubmed

Control of cardiac growth by histone acetylation/deacetylation.

HDAC5 HDAC4

6.77e-06291216397154
Pubmed

Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization.

AQP7P3 AQP7

6.77e-06291221130427
Pubmed

The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator.

AQP7P3 AQP7

6.77e-06291219297367
Pubmed

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration.

HDAC4 RUNX2

6.77e-06291225424126
Pubmed

AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism.

AQP7P3 AQP7

6.77e-06291217077387
Pubmed

Dynamic subcellular localization of aquaporin-7 in white adipocytes.

AQP7P3 AQP7

6.77e-06291225643985
Pubmed

Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.

AQP7P3 AQP7

6.77e-0629129714739
Pubmed

A new role for aquaporin 7 in insulin secretion.

AQP7P3 AQP7

6.77e-06291222415076
Pubmed

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

HDAC9 HDAC5

6.77e-06291217988634
Pubmed

Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10.

HDAC9 HDAC5 HDAC4

9.47e-061691316873063
Pubmed

HDAC family: What are the cancer relevant targets?

HDAC9 HDAC5 HDAC4

1.37e-051891318824292
Pubmed

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

MAGI2 ZBP1 SCAF11

1.91e-052091319668339
Pubmed

Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.

HDAC9 HDAC5 HDAC4

1.91e-052091321421818
Pubmed

Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.

AQP7P3 AQP7

2.03e-05391212351427
Pubmed

Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes.

AQP7P3 AQP7

2.03e-05391220573496
Pubmed

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness.

HDAC9 HDAC4

2.03e-05391228419090
Pubmed

Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.

AQP7P3 AQP7

2.03e-05391215998844
Pubmed

NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.

HDAC5 HDAC4

2.03e-05391222648949
Pubmed

HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.

HDAC9 HDAC4

2.03e-05391227333946
Pubmed

Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.

AQP7P3 AQP7

2.03e-05391216009937
Pubmed

Adipocyte lipolysis drives acute stress-induced insulin resistance.

AQP7P3 AQP7

2.03e-05391233097799
Pubmed

Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.

AQP7P3 AQP7

2.03e-05391238064372
Pubmed

RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN.

BRD4 RUNX2

2.03e-05391228981843
Pubmed

Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.

HDAC5 HDAC4

2.03e-05391211509672
Pubmed

G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.

HDAC5 HDAC4

2.03e-05391216221676
Pubmed

Channel-dependent permeation of water and glycerol in mouse morulae.

AQP7P3 AQP7

2.03e-05391216339044
Pubmed

HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity.

HDAC4 RUNX2

2.03e-05391219509297
Pubmed

Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.

HDAC5 HDAC4

2.03e-05391234502418
Pubmed

Histone deacetylase 5 is a phosphorylation substrate of protein kinase D in osteoclasts.

HDAC5 HDAC4

2.03e-05391235318161
Pubmed

c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.

ABL1 SYNM

2.03e-05391233019757
Pubmed

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.

HDAC5 HDAC4

2.03e-05391232612176
Pubmed

HDAC4 deacetylase associates with and represses the MEF2 transcription factor.

HDAC9 HDAC4

2.03e-05391210487761
Pubmed

Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle.

AQP7P3 AQP7

2.03e-05391227746040
Pubmed

Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes.

KIF23 PCNT

2.03e-05391220186884
Pubmed

Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells.

HDAC9 HDAC4

2.03e-05391231754707
Pubmed

Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa.

AQP7P3 AQP7

2.03e-05391218829704
Pubmed

MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression.

HDAC4 RUNX2

2.03e-05391227563877
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

MAGI2 ADAMTS19 EXOSC9 CYP2B6 FRRS1 DONSON PITRM1 TTLL11 TENT5C SYT1 SCAF11 PXYLP1 RBM47

2.09e-051242911330973865
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

MAGI2 HDAC4 NRXN2 TASOR SSPOP

2.43e-0513091512421765
Pubmed

Chromatin regulation by Brg1 underlies heart muscle development and disease.

HDAC9 HDAC5 GATA4

3.82e-052591320596014
Pubmed

LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.

HDAC9 HDAC5

4.05e-05491234119632
Pubmed

Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5.

HDAC5 HDAC4

4.05e-05491217949687
Pubmed

Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.

HDAC5 HDAC4

4.05e-05491228688716
InteractionANKRA2 interactions

HDAC9 ABL1 HDAC5 HDAC4

1.02e-0534814int:ANKRA2
InteractionSPTAN1 interactions

ATP8B3 KIF23 ABL1 HDAC5 HDAC4 UBR5 BRD4 HSPB2 ZFPL1 PCNT

2.93e-054968110int:SPTAN1
InteractionFRY interactions

KIF23 HDAC5 HDAC4

3.37e-0516813int:FRY
InteractionHDAC3 interactions

HDAC9 HDAC5 HDAC4 BRD4 SEC16A GATA4 DACH1 RUNX2

3.72e-05313818int:HDAC3
InteractionTUBGCP3 interactions

SIGLEC12 EPPK1 HDAC5 UBR5 SCAF11 CTPS1 PCNT

3.80e-05229817int:TUBGCP3
InteractionSOX9 interactions

KMT2C KLHL1 HDAC5 BRD4 RUNX2

4.47e-0597815int:SOX9
InteractionCAMK1 interactions

HDAC9 HDAC5 HDAC4 NUP210 SEC16A

5.95e-05103815int:CAMK1
InteractionMEF2C interactions

HDAC9 HDAC5 HDAC4 GATA4

6.57e-0554814int:MEF2C
Cytoband8p23.1

FAM90A17 FAM90A19 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

8.96e-101549188p23.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

FAM90A17 FAM90A19 GATA4 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

1.09e-09234919chr8p23
GeneFamilyHistone deacetylases, class IIA

HDAC9 HDAC5 HDAC4

8.44e-084513992
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 SULF2 EXPH5 DACH1 CMYA5 WDR49

3.18e-08168847fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 SULF2 EXPH5 DACH1 CMYA5 WDR49

3.18e-08168847315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-pDC|lymph-node_spleen / Manually curated celltypes from each tissue

SULF2 DACH1 ADAM33 RUNX2 TNFRSF21 WDR49 LILRB4

3.18e-08168847cfed36fece51871a5abbcde71f6bd5e7212357ff
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 SULF2 EXPH5 DACH1 CMYA5 WDR49

3.18e-08168847e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 SULF2 EXPH5 DACH1 CMYA5 WDR49

5.71e-08183847eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellCTRL-Lymphoid-pDC|Lymphoid / Disease state, Lineage and Cell class

SULF2 DACH1 ARHGEF17 TNFRSF21 WDR49 LILRB4

9.72e-07174846ff4315e9fad198cc323fc987deb8652da137cf98
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 CMYA5 WDR49

1.15e-061798467394e77e665bf16d3733df91bb12907be460ab44
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 CMYA5 WDR49

1.22e-061818465bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 CMYA5 WDR49

1.22e-061818468e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 SULF2 EXPH5 DACH1 WDR49

1.30e-06183846612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 CMYA5 WDR49

1.39e-061858469197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 CMYA5 WDR49

1.39e-06185846ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

MS4A4A KIF23 VILL SEC16A GAS7 RBM47

1.48e-061878463c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF2 HRC SYT1 PLEKHG2 ARHGEF17 INPP4B

1.48e-0618784648bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF2 HRC SYT1 PLEKHG2 ARHGEF17 INPP4B

1.48e-06187846958402fcc78f4c7a7d13d659d776f3817137975f
ToppCellBiopsy_Control_(H.)-Immune-pDCs|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

HDAC9 SULF2 RUNX2 TNFRSF21 FER1L6 LILRB4

1.88e-0619584647d139215f0b51f5ea9b5fb09b1100e320e3f1e2
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

1.13e-05155845e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

1.13e-051558455a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCelldroplet-Marrow-BM-30m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBP1 SULF2 VILL SMOX LILRB4

1.31e-05160845822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM HRC SYT1 PLEKHG2 ARHGEF17

1.40e-05162845c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM HRC SYT1 PLEKHG2 ARHGEF17

1.40e-05162845f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCelldroplet-Marrow-BM-30m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBP1 SULF2 VILL SMOX LILRB4

1.40e-0516284576e289ad9fd3694f77fd0d19e74c1cb8e87b8094
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM HRC SYT1 PLEKHG2 ARHGEF17

1.40e-051628455d902bb31e691aea9749617cc88303c2448f24b8
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf|Thalamus / BrainAtlas - Mouse McCarroll V32

FAT2 CTPS1 SSPOP FBXL5

1.45e-05788445b45aacaff2a2b98c4ef8e7ac51ad482a69a1d8b
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)|Thalamus / BrainAtlas - Mouse McCarroll V32

FAT2 CTPS1 SSPOP FBXL5

1.45e-0578844afed2f358c8a33889931bc5ad8cb24f92323e6f8
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

EXPH5 TTLL11 DACH1 RUNX2 TNFRSF21

1.66e-05168845968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

1.66e-05168845dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

DACH1 ADAM33 RUNX2 TNFRSF21 LILRB4

1.76e-0517084559cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCellCOVID-pDC|COVID / Condition, Cell_class and T cell subcluster

DACH1 RUNX2 TNFRSF21 WDR49 LILRB4

1.86e-051728453ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCelldroplet-Lung-nan-18m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBP1 VILL GAS7 TNFRSF21 LILRB4

1.86e-0517284535d09640d5b04fa0bbb1b40d4b8f97da587a5046
ToppCelldroplet-Lung-nan-18m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBP1 VILL GAS7 TNFRSF21 LILRB4

1.86e-0517284598cb64e2a768908105701a7a5b58f336036250fd
ToppCellCOVID-pDC-|COVID / Condition, Cell_class and T cell subcluster

DACH1 RUNX2 TNFRSF21 WDR49 LILRB4

1.86e-05172845a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ZSWIM5 ARHGEF17 SSPOP TNFRSF21

1.92e-05173845d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

AFF2 SYNM DACH1 ARHGEF17 INPP4B

1.92e-05173845fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HDAC9 MACROH2A2 TNFRSF21 WDR49 LILRB4

1.92e-05173845a55f310c533432e9e26e400026a5b47245152976
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HDAC9 MACROH2A2 TNFRSF21 WDR49 LILRB4

1.92e-051738459c7386bf0a899882c733f0b4921a96afde032a7d
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ZSWIM5 ARHGEF17 SSPOP TNFRSF21

1.92e-051738453c852ffe22f4a5b632463086b08c669310684e80
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.02e-05175845a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellB_cells-pDCs|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

2.08e-05176845ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF2 GATA4 SCAF11 CMYA5 TASOR

2.08e-05176845749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF2 DACH1 PLEKHG2 ARHGEF17 INPP4B

2.14e-051778454943d040eee0f9dceaddc7498171281d170e271f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KLHL1 AFF2 VILL EXPH5 DACH1

2.14e-0517784564fbf799e7b0c4003b2f486cc41b0f7e7c11ea0c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF2 DACH1 PLEKHG2 ARHGEF17 INPP4B

2.14e-051778453f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.14e-051778454d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF2 SYNM DACH1 ARHGEF17 INPP4B

2.20e-05178845185b44700f06ec58b3c09c80520502166c965fd6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.20e-05178845edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCellNS-moderate-d_16-33-Myeloid-pDC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SULF2 DACH1 ADAM33 RUNX2 LILRB4

2.32e-05180845144818e69613296cde43f29cb8c20899c670b319
ToppCellICU-NoSEP-Myeloid-tDC|ICU-NoSEP / Disease, Lineage and Cell Type

ATP8B3 ADAM33 RUNX2 SMOX TNFRSF21

2.32e-05180845be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF2 SYNM HRC ARHGEF17 INPP4B

2.38e-05181845451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellPericytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

SYNM HRC ADAM33 HSPB2 INPP4B

2.44e-0518284546c213597445b1f4f09dc367f27702d24b201daf
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.51e-05183845fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.51e-051838453c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.51e-051838459c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM5 PLEKHG2 ARHGEF17 TNFRSF21 INPP4B

2.51e-051838450f02136359787bd78146617990968baa47a65d86
ToppCell(7)_DC_plasmacytoid|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

2.51e-051838452c6475c935b5a90931be6b3c53f1f707cfcd11f4
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM5 PLEKHG2 ARHGEF17 TNFRSF21 INPP4B

2.51e-051838452f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.51e-051838457c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_int|lung / Disease (COVID-19 only), tissue and cell type

HDAC9 ZBP1 NUP210 TENT5C SYT1

2.57e-05184845480595a0e2e6aa2a77b7daa36490ae3af3d8dfee
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.57e-051848457294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 WDR49

2.64e-05185845b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

KIF23 CCDC150 RUNX2 WDR49 LILRB4

2.64e-051858459d3168c7f0b1d739f78b368969cf5c77ce202b97
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

HDAC9 ZBP1 NUP210 TENT5C SYT1

2.71e-0518684566676d9395172de5707e204826a1c9f73b448cca
ToppCellhealthy_donor-Lymphocytic-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

2.71e-05186845916f2aeea4989ba7a29e071e348a51010f010223
ToppCellhealthy_donor-Lymphocytic-Dendritic-pDC|healthy_donor / Disease condition, Lineage, Cell class and subclass

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

2.71e-0518684545f66619e45d590c7365a51782d4ac46b7d31fde
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 NRXN2 ERC1 EXPH5 SYT1

2.78e-05187845ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AFF2 SYNM HRC ARHGEF17 INPP4B

2.78e-05187845fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF2 SYNM DACH1 ARHGEF17 INPP4B

2.78e-0518784586250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

MAGI2 ADAMTS19 EXPH5 RTTN DACH1

2.78e-051878457e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI2 ADAMTS19 EXPH5 DACH1 CMYA5

2.78e-0518784524c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell10x5'-blood-Myeloid_Dendritic-DC2|blood / Manually curated celltypes from each tissue

HDAC9 MS4A4A SULF2 TNFRSF21 LILRB4

2.78e-05187845ab9c9930341527122f26fe5544c5c4818d1fd1b5
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF2 SYNM DACH1 ARHGEF17 INPP4B

2.85e-05188845ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 UBR5 EXPH5 RTTN DACH1

2.85e-05188845b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF2 SYT1 PLEKHG2 ARHGEF17 INPP4B

2.93e-05189845fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

MAGI2 CYP2B6 TENT5C RUNX2 INPP4B

3.00e-05190845756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AFF2 SYNM DACH1 ARHGEF17 INPP4B

3.00e-051908454eb92aef1ee868f4537483d19014d947b7684612
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIF23 CEP85 RTTN WDR49 PCNT

3.00e-05190845250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AFF2 SYNM DACH1 ARHGEF17 INPP4B

3.00e-051908457be4341e2909101d756f14031c21e705eb45e69a
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SULF2 AFF2 GATA4 HRC CMYA5

3.00e-0519084596a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCellCOVID-19_Moderate-pDC|World / disease group, cell group and cell class

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

3.08e-0519184593adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCellCOVID-19_Moderate-pDC|COVID-19_Moderate / disease group, cell group and cell class

SULF2 DACH1 RUNX2 TNFRSF21 LILRB4

3.08e-051918459d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HDAC9 SULF2 MACROH2A2 TNFRSF21 LILRB4

3.08e-0519184592c5a26b90a55831039220341d863cf2940f3c9b
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HDAC9 SULF2 MACROH2A2 TNFRSF21 LILRB4

3.16e-051928456184163dbfca882824cb266bb9030d9f79e3acb0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

HDAC9 AFF2 HRC ARHGEF17 INPP4B

3.16e-051928455000440dc1ed17e7474d340921bdff945646f27e
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DACH1 SYT1 GAS7 LRRC7 RUNX2

3.23e-05193845e2b455387d1de7812305200a2041a0f4759a6f54
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PXYLP1 CMYA5 TNFRSF21 AQP7 INPP4B

3.32e-051948454579b4a44f7c731553a284843c296866027d7c0e
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AFF2 HRC ADAM33 ARHGEF17 HSPB2

3.32e-051948456a4e7f1bf67bad94cd8c472e7c66798b0c25ba01
ToppCellIPF-Stromal-Pericyte|World / Disease state, Lineage and Cell class

AFF2 HRC ARHGEF17 HSPB2 INPP4B

3.32e-051948451a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell10x5'-bone_marrow-Myeloid_Dendritic|bone_marrow / Manually curated celltypes from each tissue

HDAC9 SULF2 RUNX2 TNFRSF21 LILRB4

3.32e-05194845768271ae45ff9f6aa3cd9b0ed15fa3caaa68a7b0
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KIF23 CEP85 RTTN WDR49 PCNT

3.32e-05194845dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM HRC ARHGEF17 HSPB2 INPP4B

3.40e-05195845e10b21e4dba4483efc4c82d6e395524246ca14a8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 MS4A4A GAS7 RBM47 LILRB4

3.40e-05195845247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PXYLP1 CMYA5 TNFRSF21 AQP7 INPP4B

3.40e-051958453d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellIPF-Stromal-Pericyte|IPF / Disease state, Lineage and Cell class

AFF2 HRC ARHGEF17 HSPB2 INPP4B

3.48e-051968458b6ff47ce5291d223f5e639fc45cd9267f418256
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AFF2 SYNM DACH1 ARHGEF17 INPP4B

3.57e-05197845f66945f9007d59d4208849c7fd727f8519713fbc
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HDAC9 SULF2 RUNX2 TNFRSF21 LILRB4

3.57e-0519784589fe4885efc8db142c0dc0506840ae8aceba9ef9
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HDAC9 MS4A4A GAS7 RBM47 LILRB4

3.57e-05197845e2983ae16c72371fbf0e5c123de9f4d900724e5e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM HRC ARHGEF17 HSPB2 INPP4B

3.57e-05197845d14e1f2ba94240c61eac435db43508a224d606a8
ToppCellmild_COVID-19-cDC|World / disease group, cell group and cell class (v2)

HDAC9 SULF2 RUNX2 TNFRSF21 LILRB4

3.57e-0519784563e7b040c64f1e28b8db79980c7b580caa7d1b95
ToppCellParenchymal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AFF2 SYNM DACH1 ARHGEF17 INPP4B

3.57e-0519784541dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCellGlobus_pallidus-Hematopoietic-MACROPHAGE|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MS4A4A ADAM33 RBM47 LILRB4

3.57e-0598844fcb9da8b676f57facfdfc0ccaca585acaa6396f2
Drugms-27

HDAC9 HDAC5 HDAC4

4.99e-075853CID016122504
DrugApicidin

HDAC9 ABL1 HDAC5 HDAC4 GATA4 CTPS1

4.16e-06113856CID000467801
DrugNatamycin [7681-93-8]; Down 200; 6uM; MCF7; HT_HG-U133A

EPPK1 CEP85 EXPH5 GAS7 ARHGEF17 ZFPL1 FBXL5

9.73e-061998573548_DN
Diseaselaryngeal carcinoma (is_marker_for)

KMT2C UBR5

1.08e-046802DOID:2600 (is_marker_for)
DiseasePULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED

HDAC5 HDAC4

1.51e-047802C1969342
DiseasePulmonary Hypertension, Primary, Fenfluramine-Associated

HDAC5 HDAC4

1.51e-047802C1969343
DiseasePulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia

HDAC5 HDAC4

1.51e-047802C3714844
DiseasePulmonary Hypertension, Primary, 1

HDAC5 HDAC4

1.51e-047802C4552070
DiseaseIntellectual Disability

KMT2C HDAC4 PITRM1 NRXN2 BRD4 RTTN SYT1

2.14e-04447807C3714756
DiseaseCocaine-Related Disorders

HDAC5 HDAC4 LRRC7 RUNX2

2.94e-04117804C0236736
DiseaseCocaine Abuse

HDAC5 HDAC4 LRRC7 RUNX2

4.02e-04127804C0009171
Diseaseperipheral arterial disease

HDAC9 SYT1 CSMD3

4.31e-0454803EFO_0004265
DiseaseCocaine Dependence

HDAC5 HDAC4 LRRC7 RUNX2

5.65e-04139804C0600427
DiseaseMalignant neoplasm of breast

ADAMTS19 SULF2 ABL1 HDAC4 ZSWIM5 ADAM33 LRRC7 DLEC1 SMOX INPP4B

6.40e-0410748010C0006142
DiseaseIdiopathic pulmonary arterial hypertension

HDAC5 HDAC4

8.50e-0416802C3203102
DiseaseFamilial primary pulmonary hypertension

HDAC5 HDAC4

9.61e-0417802C0340543
Diseaseplatelet component distribution width

STIM1 HDAC9 RTTN GATA4 TENT5C ADAM33 DLEC1 INPP4B

1.01e-03755808EFO_0007984
DiseaseQRS duration

MS4A4A UBR5 SYT1 GAS7 DLEC1

1.32e-03298805EFO_0005055
DiseaseOsteoarthritis of hip

HDAC9 RUNX2

1.34e-0320802C0029410
Diseaseacute myeloid leukemia (is_implicated_in)

CYP2B6 ABL1 DLEC1

1.56e-0384803DOID:9119 (is_implicated_in)
Diseaseplatelet measurement

HDAC9 EPPK1 RTTN TASOR INPP4B

1.68e-03315805EFO_0005036
Diseasemean platelet volume

STIM1 HDAC9 HDAC5 RTTN GATA4 TENT5C TASOR TNFRSF21 WDR49

1.75e-031020809EFO_0004584
DiseaseFEV/FEC ratio

STIM1 HDAC9 HDAC4 ERC1 ADAM33 TRPM8 DLEC1 RUNX2 ARHGEF17 INPP4B

1.76e-0312288010EFO_0004713
Diseasesensory peripheral neuropathy, remission

GAS7 DLEC1

1.77e-0323802EFO_0009785, MONDO_0002321
Diseasephysical activity

HDAC9 MAGI2 LRRC7

1.78e-0388803EFO_0003940
Diseaseosteoarthritis, hip

HDAC9 RUNX2 SMOX

2.03e-0392803EFO_1000786
Diseasenose morphology measurement

HDAC9 C16orf82 DLEC1 RUNX2 SMOX

2.03e-03329805EFO_0007843
Diseaseneuropsychological test

KLHL1 C16orf82 PXYLP1 FER1L6

2.05e-03197804EFO_0003926
Diseasemiddle cerebral artery infarction (biomarker_via_orthology)

HDAC9 HDAC5 HDAC4

2.09e-0393803DOID:3525 (biomarker_via_orthology)
DiseaseSquamous cell carcinoma of esophagus

KMT2C FAT2 DLEC1

2.22e-0395803C0279626
Diseasetransforming growth factor beta measurement

CEP85 DLEC1

2.44e-0327802EFO_0004818
Diseasecerebral white matter volume change measurement, age at assessment

GAS7 TNFRSF21

2.62e-0328802EFO_0008007, EFO_0021499
Diseasespontaneous preterm birth

HDAC9 KLHL1 DLEC1

2.64e-03101803EFO_0006917
Diseasechronic obstructive pulmonary disease

HDAC9 CYP2B6 HDAC4 ADAM33 DLEC1 RUNX2 ARHGEF17

2.65e-03688807EFO_0000341

Protein segments in the cluster

PeptideGeneStartEntry
DLLPMGVPHIVTQHT

CYP2B6

361

P20813
TPAHANVVGMDLPSH

CSMD3

3416

Q7Z407
TGHLREAPSPLMIHS

BRD4

1056

O60885
GPVTIPQRIHHMAAS

AFF2

1231

P51816
HIGSMRVEGIVHPTT

MACROH2A2

206

Q9P0M6
LAPHMVPVDSTVHLD

ADAM33

586

Q9BZ11
EIFTMEPLPHVHRES

ATP8B3

1231

O60423
VTSPENSHIMPHSVP

DACH1

296

Q9UI36
EHLRVASGPMPVHTT

FAM90A10

141

A6NDY2
DTIAFGEHHLPPVSM

ERC1

121

Q8IUD2
GEHHLPPVSMASTVP

ERC1

126

Q8IUD2
HTVEHMISPIAVQPD

RBM47

471

A0AV96
IEPLNDTMAITGHPH

ADAMTS19

256

Q8TE59
DSVHVPGPHAMTIQE

PTPN9

276

P43378
EHLRVASGPMPVHTT

FAM90A7

141

A6NKC0
HVRHASVPATFMPIV

ARHGEF17

956

Q96PE2
APTMIPEPTHLHADS

CDRT4

111

Q8N9R6
VHPLLPGSSTIMIHD

NUP210

946

Q8TEM1
HTTVISGHTSPVRMP

KMT2C

3316

Q8NEZ4
VVRPPGHHAEESTPM

HDAC4

796

P56524
ITDRPPHSLHSMPTD

MAGI2

561

Q86UL8
MSGRSVPHAHPATAE

HSPB2

1

Q16082
HQAEFPMSPVTSVHG

LILRB4

176

Q8NHJ6
VHPANEMRIGELHPS

LRRC7

631

Q96NW7
SVHPAPPLHESMALE

AQP7P3

326

A6NL99
PPVMRGQDSIPHHSD

INPP4B

501

O15327
VHSTPPTTLMEPHRI

C9orf131

516

Q5VYM1
TPEERDPVPLSIHHM

EXOSC9

176

Q06265
SAHRHSTPVVMPEPN

FAT2

4206

Q9NYQ8
GSEHSQPIMAHPPET

FAM151B

66

Q6UXP7
GREIHATIPETGLMH

NRDE2

1056

Q9H7Z3
HPMEGPAHLTLNSEV

NRXN2

246

Q9P2S2
PASHPMRSHTEVTVT

EXPH5

661

Q8NEV8
HGITVLPKMGSHEPT

AQP7

296

O14520
SVHPAPPLHESMALE

AQP7

326

O14520
DHLRVASGPMPVHTT

FAM90A17

141

P0DV74
DHLRVASGPMPVHTT

FAM90A16

141

P0DV73
TVSDHPPEQHGMFTV

PCNT

121

O95613
DHLRVASGPMPVHTT

FAM90A19

141

P0DV76
DHLRVASGPMPVHTT

FAM90A8

141

A6NJQ4
VSAMSGHGPSIHPVL

GATA4

386

P43694
HMETTVSRPVLSPTH

CCDC150

6

Q8NCX0
HETPEHTAGTLVMPK

C6orf52

76

Q5T4I8
QPSHLTGRSHPVMDS

FRRS1

271

Q6ZNA5
MPRSELTPERHTVHT

CMYA5

2836

Q8N3K9
HVTIPTAHVMPSTLG

CEP85

86

Q6P2H3
HRDTTDVPEMPHSKG

ABL1

541

P00519
GVVLILPSHSHMAET

MS4A4A

216

Q96JQ5
EITGPIMPHSLHSLT

DONSON

471

Q9NYP3
HSTGITHLPPEVMLS

FBXL5

201

Q9UKA1
IIRPPGHHAEESTAM

HDAC5

826

Q9UQL6
VVRPPGHHAEESTAM

HDAC9

776

Q9UKV0
IMPRKGVLSPHTDHE

DLEC1

681

Q9Y238
HLHTGVPLMQVATPT

SCAF11

1256

Q99590
STHSPHSPEREMGLL

IPO4

126

Q8TEX9
ETVMQPHVPHAITVS

KIF23

831

Q02241
GDVAHDVPIPMASTT

FER1L6

541

Q2WGJ9
PHDNRTMVEIIADHP

RUNX2

96

Q13950
SRISVHSPLDMGHID

RTTN

346

Q86VV8
MVSESHHEALAAPPV

SYT1

1

P21579
HHGESVQMVTTTPIP

SSPOP

2336

A2VEC9
GTAIFPRPEHMETHE

TNFRSF21

226

O75509
PRPEHMETHEVPSST

TNFRSF21

231

O75509
VHMEGLPGSSTSIRH

SYNM

1296

O15061
APHIPVHLGAMQETV

OPLAH

786

O14841
GTPAHPPETAHMSVR

GAS7

136

O60861
DHLRVASGPMPVHTT

FAM90A9

141

A6NNJ1
TGGIIDPTSHHHLPM

EPPK1

1046

P58107
DPTSHHHLPMPVAIQ

EPPK1

1051

P58107
PMDSTGVPHILEHTV

PITRM1

96

Q5JRX3
PTTSHPVVVDMPEHN

CTPS1

426

P17812
PSVAERSMEGHAPHH

PXYLP1

71

Q8TE99
MSHHPPGHTVVKDRS

HRC

461

P23327
MTSNGSHRLIEGVHP

STIM1

551

Q13586
VHVTALTHMPTFSIP

SIGLEC12

266

Q96PQ1
HIPTMPSTGVPHSLV

PLAGL2

301

Q9UPG8
PISEHFHPTVIGESM

TENT5C

201

Q5VWP2
HATELMVTSDHIVPG

TASOR

1166

Q9UK61
MSTDSPPTHGQDIHV

SPATA19

71

Q7Z5L4
PSMRIEHEHELSPGV

TTLL11

536

Q8NHH1
DTSHPHHMVSVVPSR

ZSWIM5

776

Q9P217
EMRLHGVPSEGPAHI

ZBP1

271

Q9H171
ITQEHFSHMELPGPR

RBP3

516

P10745
STTEAVHMLPHAGAP

SEC16A

681

O15027
QPSHPMADHSTTGVR

WDR49

346

Q8IV35
TEIPGAHHIIPSGFM

SMOX

226

Q9NWM0
VLVQEHVTMGSEPPH

VILL

466

O15195
QVPATTPLPEHRSHM

PLEKHG2

981

Q9H7P9
MDIELHDVSPITRHP

TRPM8

546

Q7Z2W7
PSHTRLHLTSPITMG

C16orf82

11

Q7Z2V1
VLMVISHAAPHGPED

SULF2

216

Q8IWU5
HTVIHMGNPEPLTHA

ZFPL1

196

O95159
PVGTAHIPPTMHLES

ZNF449

131

Q6P9G9
MTSIHFVVHPLPGTE

UBR5

1

O95071
MPLASPIQHHEVTRG

PRO3102

1

Q9H379
PIQHHEVTRGVAPSM

PRO3102

6

Q9H379
DHLRVASGPMPVHTT

FAM90A18

141

P0DV75
LPPMSTHRHGLGVTV

KLHL1

536

Q9NR64