Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	nucleoside bisphosphate metabolic process	TPST2 PDHB ACSS1 ACOT7 ACSS2 PPT2 ACOT2 ACSM2B	4.39e-06	142	135	8	GO:0033865
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate metabolic process	TPST2 PDHB ACSS1 ACOT7 ACSS2 PPT2 ACOT2 ACSM2B	4.39e-06	142	135	8	GO:0033875
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate metabolic process	TPST2 PDHB ACSS1 ACOT7 ACSS2 PPT2 ACOT2 ACSM2B	4.39e-06	142	135	8	GO:0034032
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	PDHB ACSS1 ACOT7 ACSS2 PPT2 ACOT2 ACSM2B	7.53e-06	109	135	7	GO:0006637
GeneOntologyBiologicalProcess	thioester metabolic process	PDHB ACSS1 ACOT7 ACSS2 PPT2 ACOT2 ACSM2B	7.53e-06	109	135	7	GO:0035383
GeneOntologyBiologicalProcess	propionate biosynthetic process	ACSS1 ACSS2	4.25e-05	2	135	2	GO:0019542
GeneOntologyBiologicalProcess	acetate biosynthetic process	ACSS1 ACSS2	4.25e-05	2	135	2	GO:0019413
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process from acetate	ACSS1 ACSS2	4.25e-05	2	135	2	GO:0019427
GeneOntologyBiologicalProcess	nucleoside bisphosphate biosynthetic process	PDHB ACSS1 ACOT7 ACSS2 PPT2	4.94e-05	61	135	5	GO:0033866
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate biosynthetic process	PDHB ACSS1 ACOT7 ACSS2 PPT2	4.94e-05	61	135	5	GO:0034030
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate biosynthetic process	PDHB ACSS1 ACOT7 ACSS2 PPT2	4.94e-05	61	135	5	GO:0034033
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA catabolic process	ACOT7 ACOT2	1.27e-04	3	135	2	GO:0036116
GeneOntologyBiologicalProcess	short-chain fatty acid biosynthetic process	ACSS1 ACSS2	2.53e-04	4	135	2	GO:0051790
GeneOntologyBiologicalProcess	acetate metabolic process	ACSS1 ACSS2	2.53e-04	4	135	2	GO:0006083
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process	PDHB ACSS1 ACSS2	2.88e-04	20	135	3	GO:0006085
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	PDHB ACSS1 ACSS2 PPT2	2.96e-04	49	135	4	GO:0071616
GeneOntologyBiologicalProcess	thioester biosynthetic process	PDHB ACSS1 ACSS2 PPT2	2.96e-04	49	135	4	GO:0035384
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ALKBH4 SEMA6C TPST2 ERCC2 EPPK1 SFI1 JADE1 NUBPL ATP13A2 BIRC6 RYR1 NSD3 FANCA SLC16A5 MROH6 XXYLT1 TANC1 NUP188 AGRN BAHCC1 HR	4.93e-09	1105	142	21	35748872
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	RNF130 IMPA2 DSC3 RBM33 L2HGDH NUBPL DICER1 ECHDC3 DOCK5 LRIG3 COG1 SLC35B4 RABGAP1L XXYLT1 EMC10 NUP188 SCFD1 ALDH5A1	3.61e-07	1061	142	18	33845483
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	REXO4 KIF26B BIRC6 RYR1 FANCA DOCK5 JUP PDE12 XXYLT1 ALDH18A1 BOD1L1 NUP188 SNRNP200 ITPRIPL1 FBN3	3.79e-07	736	142	15	29676528
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ERCC2 EPPK1 STRBP RTF2 CNTNAP1 L2HGDH ANKZF1 ADAM10 BIRC6 NSD3 JUP SF3B1 PPT2 XXYLT1 ALDH18A1 EMC10 BOD1L1 NUP188	6.11e-06	1297	142	18	33545068
Pubmed	Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms.	ERCC2 OGG1 MTR	1.07e-05	11	142	3	20723587
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	REXO4 HK2 WDR36 DSC3 PDHB RTF2 ACOT7 MCM4 BIRC6 ARMCX1 JUP PDE12 SF3B1 ALDH18A1 TANC1 SCFD1 AGRN SNRNP200	1.08e-05	1353	142	18	29467282
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	HK2 STRBP L2HGDH ANKZF1 DICER1 FANCA DOCK5 MTR TANC1 PATJ AGRN HR	1.57e-05	650	142	12	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	REXO4 EPPK1 WDR36 SRSF5 STRBP MCM4 BIRC6 DICER1 SF3B1 ALDH18A1 NUP188 SNRNP200	1.64e-05	653	142	12	22586326
Pubmed	MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells.	KIF26B DICER1	1.66e-05	2	142	2	22737231
Pubmed	The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation.	CTRB2 CTRB1	1.66e-05	2	142	2	28951524
Pubmed	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.	CTRB2 CTRB1	1.66e-05	2	142	2	28754779
Pubmed	Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population.	ERCC2 OGG1	1.66e-05	2	142	2	19561388
Pubmed	Polymorphisms of DNA repair genes OGG1 and XPD and the risk of age-related cataract in Egyptians.	ERCC2 OGG1	1.66e-05	2	142	2	24868140
Pubmed	The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma.	ACSS1 ACSS2	1.66e-05	2	142	2	19617323
Pubmed	Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.	CTRB2 CTRB1	1.66e-05	2	142	2	2917002
Pubmed	Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.	ACSS1 ACSS2	1.66e-05	2	142	2	11150295
Pubmed	Genomic cloning and partial characterization of human chymotrypsinogen gene.	CTRB2 CTRB1	1.66e-05	2	142	2	8186414
Pubmed	Polymorphisms in XPD and hOGG1 and prostate cancer risk: a meta-analysis.	ERCC2 OGG1	1.66e-05	2	142	2	22890093
Pubmed	Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus.	ERCC2 OGG1	1.66e-05	2	142	2	25089939
Pubmed	Association of hOGG1 and XPD polymorphisms with urothelial carcinoma in Taiwan.	ERCC2 OGG1	1.66e-05	2	142	2	22110223
Pubmed	Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice.	CTRB2 CTRB1	1.66e-05	2	142	2	30076839
Pubmed	Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.	ADAMTS10 FBN3	1.66e-05	2	142	2	11941487
Pubmed	Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.	CTRB2 CTRB1	1.66e-05	2	142	2	33036922
Pubmed	Evolutionary relationships between laboratory mice and subspecies of Mus musculus based on the restriction fragment length variants of the chymotrypsin gene at the Prt-2 locus.	CTRB2 CTRB1	1.66e-05	2	142	2	2565717
Pubmed	Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.	ACSS1 ACSS2	1.66e-05	2	142	2	27539851
Pubmed	T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination.	TNFRSF25 TNFRSF4	1.66e-05	2	142	2	22956587
Pubmed	ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.	ARMCX2 ARMCX1	1.66e-05	2	142	2	32685472
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	PDHB ACSS1 CMPK2 L2HGDH YRDC ARMCX2 NUBPL OGG1 ECHDC3 PDE12 ALDH18A1 MRPL41 ACOT2 ALDH5A1 MOCS1 ACSM2B	1.74e-05	1136	142	16	34800366
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	REXO4 WDR36 RBM33 STRBP RTF1 SF3B1 BOD1L1 SNRNP200	2.28e-05	283	142	8	30585729
Pubmed	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	OGG1 BIRC6 DICER1 IGFBP2 MTR ALDH18A1	2.49e-05	140	142	6	20819778
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	ERCC2 EPPK1 PDHB STRBP RTF2 ACOT7 MCM4 BIRC6 PDE12 NUP188 SCFD1 SNRNP200	3.42e-05	704	142	12	29955894
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	SRSF5 PDHB L2HGDH MCM4 EXOSC5 NUBPL JUP SF3B1 MTR MRPL41 NUP188 SNRNP200	4.54e-05	725	142	12	27025967
Pubmed	Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study.	ERCC2 OGG1	4.95e-05	3	142	2	20559012
Pubmed	Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population.	ERCC2 OGG1	4.95e-05	3	142	2	23700156
Pubmed	The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.	IRF3 NSD3	4.95e-05	3	142	2	29101251
Pubmed	ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.	ARMCX2 ARMCX1	4.95e-05	3	142	2	11162520
Pubmed	Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population.	ERCC2 OGG1	4.95e-05	3	142	2	30429230
Pubmed	Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8.	CTRB2 CTRB1	4.95e-05	3	142	2	1016231
Pubmed	Subunit architecture of the conserved oligomeric Golgi complex.	COG1 COG5	4.95e-05	3	142	2	16020545
Pubmed	Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India.	ERCC2 OGG1	4.95e-05	3	142	2	20564624
Pubmed	Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.	ACOT7 ACOT2	4.95e-05	3	142	2	35215835
Pubmed	Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.	ERCC2 OGG1	4.95e-05	3	142	2	27460091
Pubmed	Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma.	ERCC2 OGG1	4.95e-05	3	142	2	20649433
Pubmed	Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.	ACSS1 ACSS2	4.95e-05	3	142	2	16788062
Pubmed	Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.	CTRB2 CTRB1	4.95e-05	3	142	2	34643096
Pubmed	Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice.	CTRB2 CTRB1	4.95e-05	3	142	2	32678161
Pubmed	DNA repair genes hOGG1, XRCC1 and ERCC2 polymorphisms and their molecular mapping in breast cancer patients from India.	ERCC2 OGG1	4.95e-05	3	142	2	32519309
Pubmed	No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study.	ERCC2 OGG1	4.95e-05	3	142	2	18349297
Pubmed	Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.	STRBP DICER1	4.95e-05	3	142	2	38280476
Pubmed	Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.	ADAM10 HR	4.95e-05	3	142	2	22834956
Pubmed	Low to high Ca2+ -switch causes phosphorylation and association of desmocollin 3 with plakoglobin and desmoglein 3 in cultured keratinocytes.	DSC3 JUP	4.95e-05	3	142	2	19348003
Pubmed	Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia.	ERCC2 OGG1	4.95e-05	3	142	2	29121049
Pubmed	Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.	CTRB2 CTRB1	4.95e-05	3	142	2	38981616
Pubmed	MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study.	ERCC2 OGG1	4.95e-05	3	142	2	20571908
Pubmed	Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes.	DSC3 JUP	4.95e-05	3	142	2	10769211
Pubmed	A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.	HK2 OGG1	4.95e-05	3	142	2	20846459
Pubmed	Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability.	DSC3 JUP	4.95e-05	3	142	2	7983064
Pubmed	Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variants of trypsin and chymotrypsin.	CTRB2 CTRB1	4.95e-05	3	142	2	1008801
Pubmed	Single nucleotide polymorphisms (SNPs) of ERCC2, hOGG1, and XRCC1 DNA repair genes and the risk of triple-negative breast cancer in Polish women.	ERCC2 OGG1	4.95e-05	3	142	2	24402573
Pubmed	DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.	ERCC2 OGG1	4.95e-05	3	142	2	21390502
Pubmed	Studies of Correlations Between Single Nucleotide Polymorphisms of DNA Repair Genes and Endometrial Cancer in Polish Women.	ERCC2 OGG1	4.95e-05	3	142	2	30194171
Pubmed	Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India.	ERCC2 OGG1	4.95e-05	3	142	2	22081374
Pubmed	[The evaluation of association between polymorphisms of DNA excision repair enzyme genes and risk of malignant tumors development in Siberian Group of Chemical Enterprises workers].	ERCC2 OGG1	9.88e-05	4	142	2	18825991
Pubmed	Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study.	ERCC2 OGG1	9.88e-05	4	142	2	16564556
Pubmed	Dicer mediating the expression of miR-143 and miR-155 regulates hexokinase II associated cellular response to hypoxia.	HK2 DICER1	9.88e-05	4	142	2	25172909
Pubmed	Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.	KIF26B ROR2	9.88e-05	4	142	2	28885975
Pubmed	Synaptic transmission is impaired at neuronal autonomic synapses in agrin-null mice.	CHRNB2 AGRN	9.88e-05	4	142	2	17443806
Pubmed	Plakoglobin as a regulator of desmocollin gene expression.	DSC3 JUP	9.88e-05	4	142	2	23652796
Pubmed	DNA repair gene variants in migraine.	ERCC2 OGG1	9.88e-05	4	142	2	24892639
Pubmed	Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.	ACSS1 ACSS2	9.88e-05	4	142	2	16790548
Pubmed	Influence of DNA repair gene polymorphisms on the yield of chromosomal aberrations.	ERCC2 OGG1	9.88e-05	4	142	2	15971256
Pubmed	DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India.	ERCC2 OGG1	9.88e-05	4	142	2	21183201
Pubmed	DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia.	ERCC2 OGG1	9.88e-05	4	142	2	23959014
Pubmed	Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients.	ERCC2 OGG1	9.88e-05	4	142	2	18977234
Pubmed	Genome-wide association study of antipsychotic-induced QTc interval prolongation.	SLC22A23 NUBPL	9.88e-05	4	142	2	20921969
Pubmed	Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract.	ERCC2 OGG1	9.88e-05	4	142	2	22306120
Pubmed	[The polymorphism of DNA repair genes XPD, XRCC1, OGG1, and ERCC6, life expectancy, and the inclination to smoke].	ERCC2 OGG1	9.88e-05	4	142	2	25731027
Pubmed	DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the hyderabad population of India.	ERCC2 OGG1	9.88e-05	4	142	2	23464476
Pubmed	Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis.	ERCC2 OGG1	9.88e-05	4	142	2	20981350
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	RNF130 AEN HK2 SRSF5 PDHB SLC22A23 YRDC JADE1 VSIG10 BIRC6 DICER1 RTF1 ALDH18A1 NUP188 COG5 KAT14	1.10e-04	1327	142	16	32694731
Pubmed	Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer.	ERCC2 OGG1	1.64e-04	5	142	2	18559563
Pubmed	Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies.	ERCC2 OGG1	1.64e-04	5	142	2	16997330
Pubmed	Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse.	CTRB2 CTRB1	1.64e-04	5	142	2	6589791
Pubmed	DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.	ERCC2 OGG1	1.64e-04	5	142	2	18006925
Pubmed	NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.	NSD3 BOD1L1	1.64e-04	5	142	2	26626481
Pubmed	Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk.	ERCC2 OGG1	1.64e-04	5	142	2	20183911
Pubmed	Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk.	ERCC2 OGG1	1.64e-04	5	142	2	18478337
Pubmed	Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts.	ERCC2 OGG1	1.64e-04	5	142	2	15887293
Pubmed	Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).	DSC3 JUP	1.64e-04	5	142	2	1889810
Pubmed	DNA repair gene polymorphisms and prostate cancer risk in South Australia--results of a pilot study.	ERCC2 OGG1	1.64e-04	5	142	2	19914098
Pubmed	Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus).	CTRB2 CTRB1	1.64e-04	5	142	2	4461036
Pubmed	Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice.	ROR2 AGRN	1.64e-04	5	142	2	31268420
Pubmed	Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.	ERCC2 OGG1	1.64e-04	5	142	2	18544627
Pubmed	A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.	UNC79 BAHCC1	1.64e-04	5	142	2	16807365
Pubmed	DNA repair genes in endometriosis.	ERCC2 OGG1	1.64e-04	5	142	2	20391347
Pubmed	Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1.	CTRB2 CTRB1	1.64e-04	5	142	2	1820020
Pubmed	Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.	ACOT7 ACOT2	1.64e-04	5	142	2	31676684
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	REXO4 HK2 WDR36 SRSF5 PDHB MCM4 DICER1 JUP PDE12 SF3B1 MTR ALDH18A1 BOD1L1 NUP188 SCFD1 SNRNP200	2.45e-04	1425	142	16	30948266
Pubmed	Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1).	ERCC2 OGG1	2.46e-04	6	142	2	19414392
Pubmed	The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.	GPR37L1 GRIP1	2.46e-04	6	142	2	24749734
Interaction	TSC22D1 interactions	EPPK1 PDHB APLP1 ADAM10 MTR SNRNP200 FBN3	6.41e-06	104	135	7	int:TSC22D1
Cytoband	Xq21.33-q22.2	ARMCX2 ARMCX1	9.50e-06	2	142	2	Xq21.33-q22.2
Cytoband	1p36	ACOT7 ATP13A2 TNFRSF4	4.25e-04	47	142	3	1p36
Cytoband	19q13.1	APLP1 EXOSC5 RYR1	6.76e-04	55	142	3	19q13.1
GeneFamily	Acyl-CoA synthetase family	ACSS1 ACSS2 ACSM2B	3.05e-04	26	92	3	40
GeneFamily	Components of oligomeric golgi complex	COG1 COG5	7.03e-04	8	92	2	493
GeneFamily	Glycosyltransferase family 8	GLT8D2 XXYLT1	9.01e-04	9	92	2	436
GeneFamily	Acyl-CoA thioesterases	ACOT7 ACOT2	1.12e-03	10	92	2	41
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMCX2 ARMCX1 JUP	1.36e-03	43	92	3	409
GeneFamily	X-linked mental retardation\|RNA helicases	DICER1 SNRNP200	1.37e-03	11	92	2	1168
GeneFamily	Exonucleases	AEN REXO4	2.93e-03	16	92	2	544
GeneFamily	Aldehyde dehydrogenases	ALDH18A1 ALDH5A1	4.14e-03	19	92	2	398
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TNFRSF25 ADAT3 SFI1 VSIG10 OGG1 FANCA FBXO31	2.29e-06	186	142	7	927723ad579bbd9947ff525bd501e222d3fa9289
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ALKBH4 WDR36 YRDC CASC2 KLHL3 UBTD1 FBXO31	2.55e-06	189	142	7	bccb3481ffed597c845fe860da658505316105b5
ToppCell	IPF-Epithelial-Basal\|IPF / Disease state, Lineage and Cell class	DSC3 SLC22A23 GRIP1 LRIG3 JUP TANC1 PATJ	2.64e-06	190	142	7	ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCell	Leuk-UTI-Lymphocyte-T_NK-MAIT\|Leuk-UTI / Disease, Lineage and Cell Type	GRM6 CHRNB2 ALDH18A1 SLC35E4 TANC1 ACSM2B	9.80e-06	153	142	6	ac3a1d1b5bf6009df818fd757dad7382d95c60dc
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	KIF26B EXOSC5 ADAMTS10 RABGAP1L MTR BAHCC1	1.67e-05	168	142	6	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A23 JADE1 GRIP1 SLC16A5 MTR FBN3	1.72e-05	169	142	6	4b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A23 JADE1 GRIP1 SLC16A5 MTR FBN3	1.72e-05	169	142	6	a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Secretory/RAS\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC22A23 EXOSC5 VSIG10 UBTD1 SLC16A5 HR	1.78e-05	170	142	6	b62f7184e78e9672ea88e361654f604f9df2dc5f
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BOC AEN MCM4 FANCA LRIG3 ITPRIPL1	1.78e-05	170	142	6	8465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC22A23 EXOSC5 VSIG10 UBTD1 SLC16A5 HR	1.78e-05	170	142	6	00fe77bca9c28762212c498f9c49e14cb1492cca
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFI1 NUBPL RYR1 FANCA S1PR4 TBX6	1.84e-05	171	142	6	e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TNFRSF25 APLP1 TNFRSF4 RABGAP1L IGLON5 S1PR4	2.10e-05	175	142	6	3bdccb4037053795d62ab5b6fcc09cdd406f9b50
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TNFRSF25 APLP1 TNFRSF4 RABGAP1L IGLON5 S1PR4	2.10e-05	175	142	6	770546ddaa49ee482c4c7577ab76efbc6c304a29
ToppCell	droplet-Lung-nan-21m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF25 TM4SF5 APLP1 VSIG10 TNFRSF4 S1PR4	2.24e-05	177	142	6	8cc74873f4d2d0f81042426a687b01750abc72d2
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF25 TM4SF5 APLP1 VSIG10 TNFRSF4 S1PR4	2.24e-05	177	142	6	fe0f6a73264632bdd4f9fbc22de2d155ba2bcf8c
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	SEMA6C TNFRSF25 CMPK2 RGS12 TNFRSF4 FBXO31	2.96e-05	186	142	6	064b6047215597465bb51a8a1547ef5a226552f9
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SEMA6C TNFRSF25 ACOT7 CMPK2 RGS12 FBXO31	3.14e-05	188	142	6	b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell	P15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TPST2 KIF26B SLC22A23 ATP13A2 RGS12 S1PR4	3.14e-05	188	142	6	c0a03e33027f52b5c25ffbc8f822128e5160ed20
ToppCell	10x5'-Liver-Myeloid_Mac-Macrophage\|Liver / Manually curated celltypes from each tissue	RNF130 ADAT3 JUP SHROOM1 IGFBP2 TBX6	3.43e-05	191	142	6	bd7fd445e3d6316d0336c109889e7e6dc394a55e
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	SEMA6C TNFRSF25 TNFRSF4 DOCK5 SCART1 TANC1	3.53e-05	192	142	6	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	DSC3 SLC22A23 LRIG3 JUP TANC1 PATJ	3.53e-05	192	142	6	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	AEN KIF26B FANCA RTF1 PDE12 NUP188	3.64e-05	193	142	6	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRSF5 ETV5 LRIG3 IGFBP2 TENM3 AGRN	3.96e-05	196	142	6	d4df86ce289835e76763213641989fde77935a16
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	DSC3 GPR37L1 GRIP1 JUP IGFBP2 NPC1L1	4.08e-05	197	142	6	751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BOC DSC3 SLC22A23 TM4SF5 GRIP1 JUP	4.08e-05	197	142	6	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	DSC3 GPR37L1 GRIP1 JUP IGFBP2 NPC1L1	4.08e-05	197	142	6	2701864e49878c5f323f5133e2c4b0a5a7fff7f5
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DSC3 GPR37L1 GRIP1 JUP IGFBP2 NPC1L1	4.08e-05	197	142	6	58d809ccb8cc4b1e76acf0b8f996cd0e2637290c
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STRBP SLC22A23 GRIP1 LRIG3 ALDH18A1 TANC1	4.43e-05	200	142	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RBM33 CMPK2 BIRC6 JUP SF3B1 BOD1L1	4.43e-05	200	142	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	VE-CD4-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	SEMA6C CNTNAP1 TNFRSF4 PPT2 SCART1	5.87e-05	129	142	5	e89d414e1b23e1656747defa39f09b51944a2166
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	GLT8D2 DSC3 APLP1 IGFBP2 TENM3	7.28e-05	135	142	5	5b13ff740d9f7d96274aebb6b389a80f6004adc7
Drug	Phe-phe-ome	BOC CTRB2 CTRB1	2.28e-07	3	140	3	CID000151728
Drug	thiobenzyl N-heptafluorobutyrylanthranilate	CEL CTRB2 CTRB1	2.28e-07	3	140	3	CID000133906
Drug	Dichlorphenamide [120-97-8]; Up 200; 13.2uM; MCF7; HT_HG-U133A	GLT8D2 TNFRSF25 ERCC2 ARMCX2 CHRNB2 FANCA UBTD1 MOCS1 TBX6	3.44e-06	195	140	9	3366_UP
Drug	Mephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	DSC3 ATP13A2 RGS12 NSD3 RTF1 DOCK5 TENM3 MOCS1 HR	3.44e-06	195	140	9	4707_DN
Drug	Biperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; MCF7; HT_HG-U133A	TNFRSF25 CEL SFI1 RGS12 FANCA ATP11B PRDM12 GPRIN2 HR	3.44e-06	195	140	9	3321_UP
Drug	Terconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A	ALKBH4 TNFRSF25 ETV5 DICER1 RGS12 FANCA RABGAP1L BAHCC1 HR	3.58e-06	196	140	9	4407_DN
Drug	3-benzyl-6-chloro-2-pyrone	CEL CTRB2 CTRB1	7.82e-06	7	140	3	CID000135053
Drug	AC1MCHYW	CEL CTRB2 CTRB1	1.25e-05	8	140	3	CID002770087
Drug	cholesteryl octanoate	CEL CTRB2 CTRB1	1.25e-05	8	140	3	CID000102015
Drug	delta(E)Phe	BOC CTRB2 CTRB1	1.86e-05	9	140	3	CID000133830
Drug	Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A	ALKBH4 TNFRSF25 YRDC SFI1 ECHDC3 AGRN MOCS1 BAHCC1	2.65e-05	193	140	8	3262_UP
Drug	Trazodone hydrochloride [25332-39-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	TNFRSF25 ERCC2 KIF26B TM4SF5 APLP1 SFI1 ANKZF1 RABGAP1L	2.75e-05	194	140	8	7410_UP
Drug	Procarbazine hydrochloride [366-70-1]; Up 200; 15.6uM; MCF7; HT_HG-U133A	GLT8D2 ERCC2 DSC3 APLP1 SFI1 CHRNB2 HR TBX6	2.85e-05	195	140	8	5452_UP
Drug	Lomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	GLT8D2 TNFRSF25 ERCC2 GPR37L1 TM4SF5 GRM6 OGG1 KLHL3	2.96e-05	196	140	8	2310_UP
Drug	Nialamide [51-12-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ETV5 TM4SF5 RGS12 CHRNB2 UBTD1 RABGAP1L NUP188 ALDH5A1	2.96e-05	196	140	8	4347_DN
Drug	BOCPheONP	CTRB2 CTRB1	3.75e-05	2	140	2	CID000111308
Drug	MPM-06	CTRB2 CTRB1	3.75e-05	2	140	2	CID000161546
Drug	NSC-374899	CTRB2 CTRB1	3.75e-05	2	140	2	CID000435726
Drug	methylbenzenebutanoate	CTRB2 CTRB1	3.75e-05	2	140	2	CID000281254
Drug	Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu	CTRB2 CTRB1	3.75e-05	2	140	2	CID004418081
Drug	propionyl-AMP	ACSS1 ACSS2	3.75e-05	2	140	2	CID000440863
Drug	c189	CTRB2 CTRB1	3.75e-05	2	140	2	CID000248048
Drug	TFMTR	TRPM5 MTR	3.75e-05	2	140	2	CID000130497
Drug	dansyl-D-arginine methyl ester	CTRB2 CTRB1	3.75e-05	2	140	2	CID000191369
Drug	methyl 6-phenylhexanoate	CTRB2 CTRB1	3.75e-05	2	140	2	CID011820300
Drug	5-aminotetrazole	CTRB2 CTRB1	3.75e-05	2	140	2	CID000020467
Drug	2-bromoisobutyric acid	CTRB2 CTRB1	3.75e-05	2	140	2	CID000074924
Drug	p-toluamidine	CTRB2 CTRB1	3.75e-05	2	140	2	CID000122753
Drug	N-acetyl-alpha-azaphenylalanine phenyl ester	CTRB2 CTRB1	3.75e-05	2	140	2	CID000191275
Drug	isobutyl sulfide	CTRB2 CTRB1	3.75e-05	2	140	2	CID000011607
Drug	statine	BOC CTRB2 ADAM10 CTRB1	4.88e-05	33	140	4	CID000123915
Drug	tryptophan-leucine	BOC CTRB2 CTRB1	6.22e-05	13	140	3	CID000323786
Drug	CoA group	TNFRSF25 PDHB ACSS1 ACOT7 L2HGDH ACSS2 PPT2 NPC1L1 ACOT2 ALDH5A1 ACSM2B	7.81e-05	433	140	11	CID000000317
Drug	Pyruvic acid	PDHB SLC16A5 SLC16A8	7.88e-05	14	140	3	DB00119
Drug	fluorescein dilaurate	CEL CTRB2 CTRB1	7.88e-05	14	140	3	CID000081743
Drug	N-acetylbenzotriazole	CTRB2 CTRB1	1.12e-04	3	140	2	CID000087784
Drug	photophor	CTRB2 CTRB1	1.12e-04	3	140	2	CID000014780
Drug	dibutyl iodomethaneboronate	CTRB2 CTRB1	1.12e-04	3	140	2	CID000098591
Drug	zinc;dipicolinate	CTRB2 CTRB1	1.12e-04	3	140	2	CID004309911
Drug	2-oxobut-3-ynoate	CTRB2 CTRB1	1.12e-04	3	140	2	CID000171547
Drug	AFMeq	CTRB2 CTRB1	1.12e-04	3	140	2	CID000194069
Drug	Bz-Cti-otbu	CTRB2 CTRB1	1.12e-04	3	140	2	CID006452691
Drug	n-(2-oxoethyl)benzamide	CTRB2 CTRB1	1.12e-04	3	140	2	CID000188995
Drug	AC1L49DM	CTRB2 CTRB1	1.12e-04	3	140	2	CID000152933
Drug	c140	CTRB2 CTRB1	1.12e-04	3	140	2	CID002783250
Drug	Benzamidomethaneboronic acid	CTRB2 CTRB1	1.12e-04	3	140	2	CID000127677
Drug	phenyl hippurate	CTRB2 CTRB1	1.12e-04	3	140	2	CID000076323
Drug	FK-386	CTRB2 CTRB1	1.12e-04	3	140	2	CID000135044
Drug	FK-375	CTRB2 CTRB1	1.12e-04	3	140	2	CID000135042
Drug	carbostyril-124	CTRB2 CTRB1	1.12e-04	3	140	2	CID000088277
Drug	N-trifluoroacetyl-4-fluorophenylalanine	CTRB2 CTRB1	1.12e-04	3	140	2	CID000328214
Drug	C18 4	CTRB2 CTRB1	1.12e-04	3	140	2	CID000077248
Drug	taraxastane	CTRB2 CTRB1	1.12e-04	3	140	2	CID006429404
Drug	phenylethaneboronic acid	CTRB2 CTRB1	1.12e-04	3	140	2	CID000065389
Drug	3-amino-2-pyridone	CTRB2 CTRB1	1.12e-04	3	140	2	CID000322353
Drug	ASA-BMPA	CTRB2 CTRB1	1.12e-04	3	140	2	CID003035649
Drug	p-nitrophenyl benzoate	CTRB2 CTRB1	1.12e-04	3	140	2	CID000070396
Drug	Z-Phe-OMe	CTRB2 CTRB1	1.12e-04	3	140	2	CID003082435
Drug	3-methylcoumarin	CTRB2 CTRB1	1.12e-04	3	140	2	CID000017130
Drug	2-propyl methylphosphonochloridate	CTRB2 CTRB1	1.12e-04	3	140	2	CID000102124
Drug	FK-316	CTRB2 CTRB1	1.12e-04	3	140	2	CID000133688
Drug	AC1L19T8	CTRB2 CTRB1	1.12e-04	3	140	2	CID000000694
Drug	Marinostatin D	CTRB2 CTRB1	1.12e-04	3	140	2	CID000132206
Drug	1FD7	CTRB2 CTRB1	1.12e-04	3	140	2	CID000445579
Drug	Glt-leu-phe-nh-meq	CTRB2 CTRB1	1.12e-04	3	140	2	CID000194914
Drug	AC1L4Z4F	CTRB2 CTRB1	1.12e-04	3	140	2	CID000194913
Drug	Glt-Phe-NH-FMeq	CTRB2 CTRB1	1.12e-04	3	140	2	CID000194912
Drug	diacetyl trimer	CTRB2 CTRB1	1.12e-04	3	140	2	CID000193527
Drug	FK-448	CTRB2 CTRB1	1.12e-04	3	140	2	CID006917869
Drug	Ac-Phe-OMe	CTRB2 CTRB1	1.12e-04	3	140	2	CID000097805
Drug	kazinol B	CTRB2 RYR1 CTRB1	1.45e-04	17	140	3	CID000480869
Drug	N-acetyltyrosine	BOC CTRB2 CTRB1	1.45e-04	17	140	3	CID000068310
Drug	Helveticoside [630-64-8]; Down 200; 7.4uM; PC3; HT_HG-U133A	TNFRSF25 APLP1 ANKZF1 ATP13A2 ALDH5A1 MOCS1 BAHCC1	1.51e-04	185	140	7	4327_DN
Drug	Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; MCF7; HT_HG-U133A	TNFRSF25 ERCC2 DSC3 CNTNAP1 SFI1 NUP188 TBX6	1.78e-04	190	140	7	4421_DN
Drug	PHA-00851261E [724719-49-7]; Up 200; 1uM; MCF7; HT_HG-U133A	TNFRSF25 ROR2 PDE12 SF3B1 SLC16A5 NUP188 GPRIN2	1.96e-04	193	140	7	3857_UP
Drug	Niridazole [61-57-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	TNFRSF25 SRSF5 CHRNB2 FANCA DOCK5 GPRIN2 HR	2.02e-04	194	140	7	3301_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	AEN L2HGDH SFI1 UBTD1 TENM3 NUP188 PATJ	2.02e-04	194	140	7	7044_UP
Drug	cumyl alcohol	CYP2D7 ACSS1 ACSS2	2.05e-04	19	140	3	CID000000325
Drug	Ceforanide [60925-61-3]; Up 200; 7.6uM; MCF7; HT_HG-U133A	TNFRSF25 RYR1 PDE12 ATP11B RABGAP1L MOCS1 TBX6	2.09e-04	195	140	7	3309_UP
Drug	Palmatine chloride [3486-67-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	APLP1 DICER1 RGS12 RYR1 NSD3 MOCS1 BAHCC1	2.09e-04	195	140	7	2795_UP
Drug	Estropipate [7280-37-7]; Up 200; 9.2uM; MCF7; HT_HG-U133A	TNFRSF25 AEN SFI1 NSD3 PDE12 NUP188 MOCS1	2.09e-04	195	140	7	6808_UP
Drug	Mexiletine hydrochloride [5370-01-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	TNFRSF25 ERCC2 SRSF5 MCM4 SFI1 FANCA GPRIN2	2.09e-04	195	140	7	3862_UP
Drug	CP-863187 [668981-07-5]; Up 200; 10uM; PC3; HT_HG-U133A	TNFRSF25 AEN CHRNB2 NSD3 PDE12 MOCS1 BAHCC1	2.15e-04	196	140	7	7512_UP
Drug	Napelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	TNFRSF25 DSC3 APLP1 DICER1 RYR1 MOCS1 HR	2.15e-04	196	140	7	6824_UP
Drug	Napelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	TNFRSF25 DSC3 ROR2 TM4SF5 SFI1 SLC16A5 HR	2.15e-04	196	140	7	6084_UP
Drug	F0447-0125; Down 200; 10uM; MCF7; HT_HG-U133A	TNFRSF25 CNTNAP1 GPR37L1 RGS12 SLC16A5 NUP188 GPRIN2	2.15e-04	196	140	7	6396_DN
Drug	Piroxicam [36322-90-4]; Up 200; 12uM; MCF7; HT_HG-U133A	TNFRSF25 ETV5 SFI1 GRM6 RGS12 FANCA RIMBP2	2.22e-04	197	140	7	2252_UP
Drug	Memantine Hydrochloride [41100-52-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	APLP1 RGS12 NSD3 PDE12 RABGAP1L MOCS1 GPRIN2	2.22e-04	197	140	7	7354_UP
Drug	Iodixanol [92339-11-2]; Up 200; 2.6uM; MCF7; HT_HG-U133A	ERCC2 SFI1 GRM6 CHRNB2 PRDM12 NUP188 TBX6	2.22e-04	197	140	7	3362_UP
Drug	Chloropyramine hydrochloride [6170-42-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	ERCC2 ETV5 CHRNB2 KLHL3 SLC16A5 PRDM12 GPRIN2	2.22e-04	197	140	7	3350_UP
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A	DSC3 ETV5 APLP1 PDE12 SLC16A5 MOCS1 HR	2.22e-04	197	140	7	4371_DN
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; HL60; HG-U133A	CEL SFI1 OGG1 RGS12 NSD3 FANCA AGRN	2.22e-04	197	140	7	1774_UP
Drug	Picrotoxinin [17617-45-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A	ERCC2 APLP1 OGG1 RGS12 UBTD1 TENM3 MOCS1	2.22e-04	197	140	7	4842_DN
Drug	Alprostadil [745-65-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A	TNFRSF25 OGG1 ATP13A2 RGS12 NSD3 PATJ HR	2.22e-04	197	140	7	7358_UP
Drug	Acetaminophen [103-90-2]; Up 200; 26.4uM; MCF7; HT_HG-U133A	TNFRSF25 RGS12 NSD3 RABGAP1L NUP188 HR TBX6	2.22e-04	197	140	7	3364_UP
Drug	Benzoyl-dl-leucine	CTRB2 CTRB1	2.23e-04	4	140	2	CID000294887
Drug	Acafcek	CTRB2 CTRB1	2.23e-04	4	140	2	CID000197677
Drug	B-1,3-od	CTRB2 CTRB1	2.23e-04	4	140	2	CID011971053
Drug	m329	BOC RNF130	2.23e-04	4	140	2	CID000075654
Drug	dehydromerodesmosine	CTRB2 CTRB1	2.23e-04	4	140	2	CID006443540
Disease	level of chymotrypsinogen B2 in blood serum	CTRB2 CTRB1	2.17e-05	2	138	2	OBA_2041192
Disease	beta-hydroxyisovalerate measurement	TNFRSF25 ACOT7 ACSM2B	3.51e-05	14	138	3	EFO_0800125
Disease	chymotrypsinogen B measurement	CTRB2 CTRB1	6.49e-05	3	138	2	EFO_0801477
Disease	Enterovirus Infections	COG1 COG5	3.22e-04	6	138	2	C0014378
Disease	hereditary spastic paraplegia (is_implicated_in)	L2HGDH ALDH18A1	4.49e-04	7	138	2	DOID:2476 (is_implicated_in)
Disease	orthostatic hypotension	PIK3AP1 CD163L1	7.65e-04	9	138	2	EFO_0005252
Disease	senile cataract (is_implicated_in)	ERCC2 OGG1	1.16e-03	11	138	2	DOID:9669 (is_implicated_in)
Disease	trypsin-2 measurement	CTRB2 CTRB1	1.16e-03	11	138	2	EFO_0008305
Disease	severe acute respiratory syndrome, COVID-19	RTF2 NUBPL GRIP1 XXYLT1 MKLN1 RIMBP2 PATJ S1PR4	1.25e-03	447	138	8	EFO_0000694, MONDO_0100096
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A2 PPT2	1.90e-03	14	138	2	DOID:14503 (implicated_via_orthology)
Disease	pancreatic cancer (is_implicated_in)	ERCC2 OGG1 FANCA MTR	1.93e-03	112	138	4	DOID:1793 (is_implicated_in)
Disease	alcohol use disorder (implicated_via_orthology)	ACSS2 RYR1 CHRNB2 UNC79 HR	2.28e-03	195	138	5	DOID:1574 (implicated_via_orthology)
Disease	ovarian cancer (is_implicated_in)	OGG1 FANCA JUP	2.31e-03	56	138	3	DOID:2394 (is_implicated_in)
Disease	age at onset, smoking initiation	GRIP1 EMC10	3.52e-03	19	138	2	EFO_0004847, EFO_0005670
Disease	acetate measurement	ACSS1 ACSS2	3.90e-03	20	138	2	EFO_0010112
Disease	citrulline measurement	KIF26B ALDH18A1	3.90e-03	20	138	2	EFO_0009777

Protein segments in the cluster

Peptide	Gene	Start	Entry
CGACITGRIMRPDDA	ACOT7	51	O00154
CGLPSFSREVVRRMG	ALKBH4	126	Q9NXW9
VAIDCEMVGTGPRGR	AEN	111	Q8WTP8
MVCVDLVARGQGRGT	ADAT3	226	Q96EY9
GRRITDVMICAGASG	CTRB2	191	Q6GPI1
RAALASCAGGMLGRP	BAHCC1	296	Q9P281
PLAVAAMLACARIGA	ACSS1	176	Q9NUB1
PFVGCLRAMRLNGVT	CNTNAP1	926	P78357
IRPGDAKAVCGEMTR	BIRC6	2901	Q9NR09
MNRVLCAPAAGAVRA	CCSMST1	1	Q4G0I0
VFMRCRLVDADGPLA	ADAM10	641	O14672
NDCVMGRSGAARGLL	AGRN	366	O00468
SGMLLPCGSDRFRGV	APLP1	191	P51693
ARMAATLILEPAGRC	ACOT2	61	P49753
PELVVAMLACARIGA	ACSS2	171	Q9NR19
RLVGADMPCSGRVEV	CD163L1	796	Q9NR16
GPPMSCVRLAERVVA	DICER1	681	Q9UPY3
AEKVGCPVGDAARMA	CEL	261	P19835
IDPACARGFARMTGV	FBN3	851	Q75N90
MAASGVPRGCDILIV	PIK3AP1	1	Q6ZUJ8
MSRVRDAGCVAAGIV	ARMCX2	1	Q7L311
LGLAPVGGMCERERS	ADAMTS10	361	Q9H324
GPLMCRGVGDQRRES	RBM33	281	Q96EV2
MSCAGRAGPARLAAL	RNF130	1	Q86XS8
MPDRACAVGSVARAL	MSL3P1	1	P0C860
RFGCRPVMLAGGLLA	SLC16A8	81	O95907
EMDRGRIAEPSVCGR	MCM4	316	P33991
AVGAAMAGLRPICEF	PDHB	96	P11177
LAMACDRAAAIGRPL	OR52W1	121	Q6IF63
GPCRQRAVMETIAVG	IL17B	161	Q9UHF5
MVPALRYLVGACGRA	L2HGDH	1	Q9H9P8
AGAMARLECAAVGHP	LRIG3	616	Q6UXM1
FRRVVDGCEMALPGL	KIF26B	1506	Q2KJY2
VARRAAQLCGAGMAA	HK2	826	P52789
ARGTCGPRVTNEMLE	CCDC9B	131	Q6ZUT6
RRFLQMVCPAGAGAL	HR	1066	O43593
VLRAFGASGPMCLRR	ECHDC3	6	Q96DC8
MAVCARLCGVGPSRG	FBXO31	1	Q5XUX0
AVAGGARMPCAELVR	IGFBP2	66	P18065
IGVAAVVRGAALMAP	OR51E1	146	Q8TCB6
AAGAMERAVVRCVPS	PDE12	31	Q6L8Q7
EACPGAVAMTPEARR	KAT14	476	Q9H8E8
ARVCLCPMIIGRGND	ERCC2	486	P18074
IPVVICAAAGRMGAT	GLT8D2	51	Q9H1C3
FMVPGKSRSEECRGR	ETV5	11	P41161
MRPRAPACAAAALGL	LRRC38	1	Q5VT99
QQVAMLARARGCPRG	MROH6	666	A6NGR9
FAGMELVACPRLVGA	TEPSIN	471	Q96N21
LVDAGVPMRALFCGV	EXOSC5	141	Q9NQT4
AAGPAGRMRCVICHR	PRDM12	236	Q9H4Q4
TGMVERLCQAFGPRL	OGG1	156	O15527
AMDGGGLSARCRVLV	PCDHB10	321	Q9UN67
GGPLDLMACRVVAAS	IMPA2	251	O14732
RAKRVREAMCPGVSG	JUP	81	P14923
CRARGPTGVEMEALT	MOCS1	581	Q9NZB8
MAIPVLEARACAAAG	ALDH18A1	151	P54886
AIERCFGMLLSPGRN	RABGAP1L	326	Q5R372
RVPAAATLAVGTMCG	NPC1L1	176	Q9UHC9
TLLARGAIVRCPMAG	PPT2	266	Q9UMR5
LEMRDPALGRRCGCV	ITPRIPL1	251	Q6GPH6
LMGAARCLPLAAAVR	MON1A	386	Q86VX9
ICSVTGAGPREERMV	BOD1L1	1741	Q8NFC6
AQMELAVGPFCRRVS	COG5	706	Q9UP83
LSMRVCVCRPGGEEE	ATP13A2	291	Q9NQ11
GVCAGAMAPPRRFVL	CMPK2	21	Q5EBM0
GAGCRQEKPREAMAV	C5orf47	46	Q569G3
GRAALLRCEAMAVPP	IGLON5	231	A6NGN9
RGACVGIFQMIIAGR	TTC26	501	A0AVF1
PILRCAAGEALGRMA	HEATR5B	866	Q9P2D3
MVAEPGAAVCAARRL	GRM6	641	O15303
CVARMPAGAVASVPA	BOC	106	Q9BWV1
CGLRRPFGVAVMDIT	DOCK5	316	Q9H7D0
IGQMRRCAVGLVDAV	COG1	66	Q8WTW3
MAAAGPRRSVRGAVC	DSC3	1	Q14574
SRGPRDCVVLMAAAG	ANKZF1	201	Q9H8Y5
GGVGPRVMLSSLCRE	LINC00315	31	P59091
RLLGDVSCRAVPFME	GPR37L1	196	O60883
AALFVRTMCGRVLPA	FANCA	746	O15360
MGCRAASGLLPGVAV	GUCA2B	1	Q16661
PPAACAAIAVMGASR	CENPVL3	21	A0A0U1RRI6
AAIAVMGASRAQCPR	CENPVL3	26	A0A0U1RRI6
AGPRDVGTCRGRQME	CASC2	16	Q8IU53
SGGAFCAPRARITMI	CLPSL2	51	Q6UWE3
ACPEGALSRVGSMFR	FAM43A	41	Q8N2R8
LARMPPEAVSRGCAI	KLHDC7A	521	Q5VTJ3
AELPSRRCRAGVVFM	KLHL3	331	Q9UH77
LMAVAAPSRARGSGC	EMC10	16	Q5UCC4
PAALLCGMREVRAGG	GPRIN2	231	O60269
PAERCGVLQIGDRVM	GRIP1	511	Q9Y3R0
MRGPGDCLARAVEAH	S1PR4	331	O95977
GECLARLAAAMPVAF	RYR1	3191	P21817
GRRITDVMICAGASG	CTRB1	191	P17538
ATAPLGGSRAMVCGR	NUBPL	21	Q8TB37
CLRALVEMARVGGAS	IRF3	371	Q14653
TRALALDCEMVGVGP	REXO4	241	Q9GZR2
MRGRLCVGRAAAAAA	RTF1	1	Q92541
RARFICPVVGLEMNG	RTF2	116	Q9BY42
MPCGAAAPARVSAQR	SFI1	1091	A8K8P3
RGETCARLGLIPCNM	RIMBP2	896	O15034
MGVLAAAARCLVRGA	MRPL41	1	Q8IXM3
MRPALAVGLVFAGCC	SLC35B4	1	Q969S0
ALGMVADCGVREARA	ALDH5A1	86	P51649
MAAGGAVAAAPECRL	MKLN1	1	Q9UL63
LAMCVVVRFLGRRGG	SLC22A23	481	A1A5C7
APGEAMERLGRAQRC	UPF3A	406	Q9H1J1
TRCVAVMGNLIPVRG	FSD2	606	A1L4K1
LRCALRDARVMPGSG	EPPK1	4566	P58107
IGLNCALGAAEMRPF	MTR	256	Q99707
EVRAAMRPACGEAGE	SHROOM1	581	Q2M3G4
DHSGMRPLDRAIGCR	TANC1	1241	Q9C0D5
RPLGAGEALRRVMEC	STRBP	256	Q96SI9
DAANCMRIGIPAERL	ROR2	296	Q01974
MCRSLRGAARLVGEP	SKIV2L	1206	Q15477
DLCGRREGMVVPESF	JADE1	616	Q6IE81
MSGCRVFIGRLNPAA	SRSF5	1	Q13243
MARRCGPVALLLGFG	CHRNB2	1	P17787
CGLQRGDRVAVMLPR	ACSM2B	101	Q68CK6
MGRTREAGCVAAGVV	ARMCX1	1	Q9P291
GEAACASVGRMLERV	ATP11B	1126	Q9Y2G3
AGRRACLGEPLARME	CYP2D7	456	A0A087X1C5
CRAVLAGLRSPRGAM	TPST2	31	O60704
RAMGTVREAAGLPRC	ZSCAN20	576	P17040
CVMRGSPADFVGLRA	RGS12	46	O14924
GVTCRMLPSAFEAGR	TRPM5	821	Q9NZQ8
RFGCRVTVMLGGVLA	SLC16A5	76	O15375
CGNSVRMLVARDPAG	PATJ	316	Q8NI35
MGALEGLRVAIGPCR	SF3B1	1231	O75533
AGETQPGEKRRRMAC	SP2	491	Q02086
MAAAAGGPCVRSSRE	NUP188	1	Q5SRE5
RCLSRDGRMAAQGAP	PHOSPHO1	11	Q8TCT1
AVPIIRCSRGTAAEM	SCFD1	206	Q8WVM8
SRVARVCKRDMGGSP	SEMA6C	256	Q9H3T2
VCKRDMGGSPRALDR	SEMA6C	261	Q9H3T2
EAMVFCRELGCGPVL	SCART1	166	Q4G0T1
PATRRGLAFCAEMGL	TENM3	91	Q9P273
AGRRMFPACRVSVTG	TBX6	116	O95947
MGNCVGRQRRERPAA	UBTD1	1	Q9HAC8
MEQRPRGCAAVAAAL	TNFRSF25	1	Q93038
VRVGLFALCDIPAGM	NSD3	1241	Q9BZ95
MCVGARRLGRGPCAA	TNFRSF4	1	P43489
GENGPVLEVICSRMR	SNRNP200	1461	O75643
MAAGGSAPEPRVLVC	VSIG10	1	Q8N0Z9
MACGNVGLRAVPLDL	SLC35E4	121	Q6ICL7
GGLMVLCPGIAAVRA	TM4SF5	56	O14894
GGLPCARAMARLGAV	XXYLT1	6	Q8NBI6
RCRGMRAAVAASVGL	YRDC	6	Q86U90
LPAGGAMIRCLENIA	UNC79	2141	Q9P2D8
PELRGAGIAAAMERA	WDR36	46	Q8NI36