Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine binding	CHRNB2 CHRNB4	2.04e-04	13	33	2	GO:0042166
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNB2 CHRNB4	3.55e-04	17	33	2	GO:0022848
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRNB2 CHRNB4	6.56e-04	23	33	2	GO:0015464
GeneOntologyBiologicalProcess	positive regulation of nervous system process	TNR DICER1 CHRNB4 WASF3	1.78e-06	57	32	4	GO:0031646
GeneOntologyBiologicalProcess	regulation of nervous system process	TNR DICER1 CHRNB2 CHRNB4 WASF3	6.94e-06	175	32	5	GO:0031644
GeneOntologyBiologicalProcess	synaptic transmission involved in micturition	CHRNB2 CHRNB4	6.99e-06	3	32	2	GO:0060084
GeneOntologyBiologicalProcess	regulation of transmission of nerve impulse	TNR CHRNB2 CHRNB4	1.08e-05	28	32	3	GO:0051969
GeneOntologyBiologicalProcess	cell morphogenesis	SART3 MACF1 ZDHHC15 DST TNR DICER1 CHRNB2 WASF3 NRP2	5.91e-05	1194	32	9	GO:0000902
GeneOntologyBiologicalProcess	cell junction organization	MACF1 SPOCK2 ZDHHC15 DST TNR CHRNB2 WASF3 NRP2	9.17e-05	974	32	8	GO:0034330
GeneOntologyBiologicalProcess	transcription elongation-coupled chromatin remodeling	SART3 SUPT5H	1.04e-04	10	32	2	GO:0140673
GeneOntologyBiologicalProcess	vestibulocochlear nerve development	CHRNB2 NRP2	1.27e-04	11	32	2	GO:0021562
GeneOntologyBiologicalProcess	micturition	CHRNB2 CHRNB4	1.27e-04	11	32	2	GO:0060073
GeneOntologyBiologicalProcess	behavioral response to nicotine	CHRNB2 CHRNB4	1.27e-04	11	32	2	GO:0035095
GeneOntologyBiologicalProcess	positive regulation of transmission of nerve impulse	TNR CHRNB4	1.80e-04	13	32	2	GO:0051971
GeneOntologyBiologicalProcess	neuron projection morphogenesis	MACF1 ZDHHC15 DST TNR DICER1 CHRNB2 NRP2	1.88e-04	802	32	7	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	MACF1 ZDHHC15 DST TNR DICER1 CHRNB2 NRP2	2.14e-04	819	32	7	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	MACF1 ZDHHC15 DST TNR DICER1 CHRNB2 NRP2	2.25e-04	826	32	7	GO:0048858
GeneOntologyBiologicalProcess	ganglion development	DICER1 NRP2	3.51e-04	18	32	2	GO:0061548
GeneOntologyBiologicalProcess	synapse organization	SPOCK2 ZDHHC15 TNR CHRNB2 WASF3 NRP2	5.69e-04	685	32	6	GO:0050808
GeneOntologyBiologicalProcess	nerve development	DICER1 CHRNB2 NRP2	6.37e-04	109	32	3	GO:0021675
GeneOntologyBiologicalProcess	transmission of nerve impulse	TNR CHRNB2 CHRNB4	6.89e-04	112	32	3	GO:0019226
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	MACF1 ZDHHC15 DST TNR CHRNB2 NRP2	9.01e-04	748	32	6	GO:0048667
GeneOntologyBiologicalProcess	positive regulation of myelination	DICER1 WASF3	9.22e-04	29	32	2	GO:0031643
GeneOntologyCellularComponent	postsynaptic specialization	MACF1 ZDHHC15 DST DICER1 CHRNB2 CHRNB4	1.20e-04	503	33	6	GO:0099572
GeneOntologyCellularComponent	postsynapse	MACF1 ZDHHC15 DST DICER1 CHRNB2 CHRNB4 WASF3 NRP2	1.44e-04	1018	33	8	GO:0098794
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRNB2 CHRNB4	3.64e-04	18	33	2	GO:0005892
GeneOntologyCellularComponent	cholinergic synapse	CHRNB2 CHRNB4	5.47e-04	22	33	2	GO:0098981
GeneOntologyCellularComponent	neuron to neuron synapse	MACF1 ZDHHC15 DST TNR DICER1	1.28e-03	523	33	5	GO:0098984
Domain	GAR	MACF1 DST	4.52e-05	6	33	2	PS51460
Domain	-	MACF1 DST	4.52e-05	6	33	2	3.30.920.20
Domain	-	MACF1 DST	4.52e-05	6	33	2	3.90.1290.10
Domain	GAS_dom	MACF1 DST	4.52e-05	6	33	2	IPR003108
Domain	GAS2	MACF1 DST	4.52e-05	6	33	2	PF02187
Domain	GAS2	MACF1 DST	4.52e-05	6	33	2	SM00243
Domain	Plectin_repeat	MACF1 DST	6.32e-05	7	33	2	IPR001101
Domain	Plectin	MACF1 DST	6.32e-05	7	33	2	PF00681
Domain	PLEC	MACF1 DST	6.32e-05	7	33	2	SM00250
Domain	Nicotinic_acetylcholine_rcpt	CHRNB2 CHRNB4	3.58e-04	16	33	2	IPR002394
Domain	DSRM	SLC4A1AP DICER1	5.08e-04	19	33	2	SM00358
Domain	dsrm	SLC4A1AP DICER1	5.64e-04	20	33	2	PF00035
Domain	Actinin_actin-bd_CS	MACF1 DST	7.48e-04	23	33	2	IPR001589
Domain	Acetylcholine_rcpt_TM	CHRNB2 CHRNB4	7.48e-04	23	33	2	IPR027361
Domain	ACTININ_2	MACF1 DST	7.48e-04	23	33	2	PS00020
Domain	-	CHRNB2 CHRNB4	7.48e-04	23	33	2	1.20.120.370
Domain	ACTININ_1	MACF1 DST	7.48e-04	23	33	2	PS00019
Domain	Spectrin	MACF1 DST	7.48e-04	23	33	2	PF00435
Domain	dsRBD_dom	SLC4A1AP DICER1	1.11e-03	28	33	2	IPR014720
Domain	Spectrin_repeat	MACF1 DST	1.19e-03	29	33	2	IPR002017
Domain	Spectrin/alpha-actinin	MACF1 DST	1.45e-03	32	33	2	IPR018159
Domain	SPEC	MACF1 DST	1.45e-03	32	33	2	SM00150
Domain	EF-hand-dom_pair	CCAR1 MACF1 SPOCK2 DST	1.57e-03	287	33	4	IPR011992
Domain	Neurotransmitter_ion_chnl_CS	CHRNB2 CHRNB4	2.86e-03	45	33	2	IPR018000
Domain	Neur_chan_memb	CHRNB2 CHRNB4	2.98e-03	46	33	2	PF02932
Domain	Neur_chan_LBD	CHRNB2 CHRNB4	3.11e-03	47	33	2	PF02931
Domain	Neur_channel	CHRNB2 CHRNB4	3.11e-03	47	33	2	IPR006201
Domain	Neur_chan_lig-bd	CHRNB2 CHRNB4	3.11e-03	47	33	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	CHRNB2 CHRNB4	3.11e-03	47	33	2	PS00236
Domain	Neurotrans-gated_channel_TM	CHRNB2 CHRNB4	3.11e-03	47	33	2	IPR006029
Domain	-	CHRNB2 CHRNB4	3.11e-03	47	33	2	2.70.170.10
Domain	CH	MACF1 DST	5.87e-03	65	33	2	SM00033
Domain	CH	MACF1 DST	6.78e-03	70	33	2	PF00307
Domain	-	MACF1 DST	6.97e-03	71	33	2	1.10.418.10
Domain	CH	MACF1 DST	7.36e-03	73	33	2	PS50021
Domain	CH-domain	MACF1 DST	7.75e-03	75	33	2	IPR001715
Pathway	REACTOME_HIGHLY_SODIUM_PERMEABLE_POSTSYNAPTIC_ACETYLCHOLINE_NICOTINIC_RECEPTORS	CHRNB2 CHRNB4	4.00e-05	7	20	2	MM15311
Pathway	REACTOME_HIGHLY_SODIUM_PERMEABLE_POSTSYNAPTIC_ACETYLCHOLINE_NICOTINIC_RECEPTORS	CHRNB2 CHRNB4	4.00e-05	7	20	2	M27596
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNB2 CHRNB4	6.84e-05	9	20	2	MM15313
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNB2 CHRNB4	6.84e-05	9	20	2	M27597
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNB2 CHRNB4	1.04e-04	11	20	2	M883
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNB2 CHRNB4	1.25e-04	12	20	2	MM15312
Pathway	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNB2 CHRNB4	1.25e-04	12	20	2	M48008
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNB2 CHRNB4	1.72e-04	14	20	2	M757
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNB2 CHRNB4	1.99e-04	15	20	2	MM14704
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY	CHRNB2 CHRNB4	3.22e-04	19	20	2	M47793
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	PCF11 SUGP1 CCAR1 MFAP1	5.98e-04	283	20	4	M13087
Pathway	WP_MRNA_PROCESSING	SUGP1 DICER1 SUPT5H	7.11e-04	126	20	3	M39406
Pathway	PID_TAP63_PATHWAY	DST DICER1	2.62e-03	54	20	2	M256
Pathway	REACTOME_METABOLISM_OF_RNA	PCF11 SUGP1 CCAR1 MFAP1 SUPT5H	2.87e-03	724	20	5	M16843
Pathway	WP_SIDS_SUSCEPTIBILITY_PATHWAYS	CHRNB2 CHRNB4	3.12e-03	59	20	2	MM15838
Pathway	REACTOME_MRNA_SPLICING	SUGP1 CCAR1 MFAP1	3.16e-03	212	20	3	M14033
Pathway	WP_MRNA_PROCESSING	SUGP1 SART3 DICER1 SUPT5H	3.33e-03	451	20	4	MM15946
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PCF11 SUGP1 CCAR1 SMARCC1 MACF1 MFAP1 SPOCK2 DST SUPT5H LSG1	3.93e-08	1082	33	10	38697112
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CEP350 MACF1 DST LARP1B DICER1 LSG1	4.24e-08	209	33	6	36779422
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEP350 CCAR1 SMARCC1 MACF1 LARP1B DICER1 LSG1 HSPH1	2.97e-07	724	33	8	36232890
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PCF11 CEP350 CCAR1 SART3 SMARCC1 MFAP1 LARP1B DICER1 LSG1 HSPH1	3.54e-07	1371	33	10	36244648
Pubmed	Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.	CHRNB2 CHRNB4	8.73e-07	2	33	2	15537871
Pubmed	Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine.	CHRNB2 CHRNB4	8.73e-07	2	33	2	21768117
Pubmed	Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.	MACF1 DST	8.73e-07	2	33	2	11002341
Pubmed	Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors.	CHRNB2 CHRNB4	8.73e-07	2	33	2	10531434
Pubmed	Varenicline blocks β2-nAChR-mediated response and activates β4-nAChR-mediated responses in mice in vivo.	CHRNB2 CHRNB4	8.73e-07	2	33	2	22241831
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 ANKRD49 CCAR1 MACF1 SPOCK2 DST SUPT5H TRIM52 HSPH1	2.16e-06	1285	33	9	35914814
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CCAR1 SART3 SMARCC1 DST DICER1 SUPT5H LSG1	2.16e-06	650	33	7	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CCAR1 SART3 SMARCC1 MACF1 DST DICER1 SUPT5H	2.23e-06	653	33	7	22586326
Pubmed	Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling.	CHRNB2 CHRNB4	2.62e-06	3	33	2	24647947
Pubmed	Nicotinic acetylcholine receptors in the autonomic control of bladder function.	CHRNB2 CHRNB4	2.62e-06	3	33	2	10771006
Pubmed	Expression of the mouse Macf2 gene during inner ear development.	MACF1 DST	2.62e-06	3	33	2	12399109
Pubmed	Hidden function of neuronal nicotinic acetylcholine receptor beta2 subunits in ganglionic transmission: comparison to alpha5 and beta4 subunits.	CHRNB2 CHRNB4	2.62e-06	3	33	2	15694199
Pubmed	Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors.	CHRNB2 CHRNB4	2.62e-06	3	33	2	32959891
Pubmed	The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion.	CHRNB2 CHRNB4	2.62e-06	3	33	2	30891952
Pubmed	Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina.	CHRNB2 CHRNB4	2.62e-06	3	33	2	11027228
Pubmed	Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.	DICER1 SUPT5H	2.62e-06	3	33	2	24814348
Pubmed	MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.	CHRNB2 CHRNB4	2.62e-06	3	33	2	26904947
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CDR2L CCAR1 SMARCC1 MACF1 DST	2.69e-06	234	33	5	36243803
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PCF11 SART3 SMARCC1 DICER1 SUPT5H LSG1	3.29e-06	440	33	6	34244565
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SUGP1 CCAR1 SMARCC1 MFAP1 SLC4A1AP	3.79e-06	251	33	5	31076518
Pubmed	Synaptic transmission is impaired at neuronal autonomic synapses in agrin-null mice.	CHRNB2 CHRNB4	5.23e-06	4	33	2	17443806
Pubmed	In vivo effects of 3-iodocytisine: pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites.	CHRNB2 CHRNB4	5.23e-06	4	33	2	19481555
Pubmed	Subunit composition of α5-containing nicotinic receptors in the rodent habenula.	CHRNB2 CHRNB4	5.23e-06	4	33	2	22380605
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	MACF1 DST	5.23e-06	4	33	2	8954775
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PCF11 CCAR1 SART3 SMARCC1 MACF1 MFAP1 DST LSG1 HSPH1	5.53e-06	1442	33	9	35575683
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	CCAR1 SART3 SMARCC1 LARP1B HSPH1	5.80e-06	274	33	5	34244482
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PCF11 SUGP1 SART3 MFAP1 SUPT5H	6.78e-06	283	33	5	30585729
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SART3 MACF1 SPOCK2 DST	7.01e-06	130	33	4	12421765
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SUGP1 SART3 SMARCC1 MFAP1 DST SLC4A1AP	7.31e-06	506	33	6	30890647
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PCF11 CCAR1 SART3 MACF1 DST SLC4A1AP DICER1 LSG1 HSPH1	7.48e-06	1497	33	9	31527615
Pubmed	Differential nicotinic acetylcholine receptor subunit expression in the human hippocampus.	CHRNB2 CHRNB4	8.72e-06	5	33	2	12663058
Pubmed	Low ethanol concentration alters CHRNA5 RNA levels during early human development.	CHRNB2 CHRNB4	8.72e-06	5	33	2	20438829
Pubmed	Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.	CHRNB2 CHRNB4	8.72e-06	5	33	2	20377613
Pubmed	Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study.	CHRNB2 CHRNB4	8.72e-06	5	33	2	8987816
Pubmed	Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.	CHRNB2 CHRNB4	8.72e-06	5	33	2	25031416
Pubmed	Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning.	CHRNB2 CHRNB4	8.72e-06	5	33	2	15489024
Pubmed	Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis.	CHRNB2 CHRNB4	8.72e-06	5	33	2	28398760
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SUGP1 CCAR1 SART3 MACF1 MFAP1 LARP1B SUPT5H	8.91e-06	807	33	7	22681889
Pubmed	Single-channel properties of α3β4, α3β4α5 and α3β4β2 nicotinic acetylcholine receptors in mice lacking specific nicotinic acetylcholine receptor subunits.	CHRNB2 CHRNB4	1.31e-05	6	33	2	23613527
Pubmed	Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion.	CHRNB2 CHRNB4	1.31e-05	6	33	2	12079404
Pubmed	Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors.	CHRNB2 CHRNB4	1.31e-05	6	33	2	23811311
Pubmed	Changes in Nicotinic Neurotransmission during Enteric Nervous System Development.	CHRNB2 CHRNB4	1.31e-05	6	33	2	25948261
Pubmed	Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task.	CHRNB2 CHRNB4	1.31e-05	6	33	2	15922075
Pubmed	α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion.	CHRNB2 CHRNB4	1.31e-05	6	33	2	21485013
Pubmed	Distribution of neuronal nicotinic acetylcholine receptor gene restriction fragment length polymorphisms in inbred and partially inbred mice.	CHRNB2 CHRNB4	1.83e-05	7	33	2	8563774
Pubmed	Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.	CHRNB2 CHRNB4	1.83e-05	7	33	2	9009220
Pubmed	Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.	CHRNB2 CHRNB4	1.83e-05	7	33	2	1505988
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	CEP350 MACF1 TNR	2.08e-05	56	33	3	9455484
Pubmed	Functional interaction between Lypd6 and nicotinic acetylcholine receptors.	CHRNB2 CHRNB4	2.44e-05	8	33	2	27344019
Pubmed	PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.	CHRNB2 CHRNB4	2.44e-05	8	33	2	18387948
Pubmed	A protein interaction landscape of breast cancer.	SMARCC1 MACF1 DST SUPT5H LSG1 HSPH1	2.61e-05	634	33	6	34591612
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PCF11 SUGP1 CCAR1 SART3 SMARCC1 MFAP1 SLC4A1AP	2.62e-05	954	33	7	36373674
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CCAR1 SART3 SMARCC1 MACF1 MFAP1 DST LSG1 HSPH1	2.99e-05	1353	33	8	29467282
Pubmed	Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.	CHRNB2 CHRNB4	3.13e-05	9	33	2	8906617
Pubmed	Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.	CHRNB2 CHRNB4	3.13e-05	9	33	2	19228980
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SUGP1 CCAR1 SMARCC1 SLC4A1AP SUPT5H LSG1 HSPH1	3.29e-05	989	33	7	36424410
Pubmed	Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.	CHRNB2 CHRNB4	3.91e-05	10	33	2	20736995
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CCAR1 SART3 SMARCC1 RIC8B DICER1 SUPT5H LSG1 HSPH1	4.33e-05	1425	33	8	30948266
Pubmed	Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.	CHRNB2 CHRNB4	4.78e-05	11	33	2	12225896
Pubmed	Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission.	CHRNB2 CHRNB4	4.78e-05	11	33	2	29791835
Pubmed	The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.	MACF1 DST	4.78e-05	11	33	2	16815997
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	CCAR1 DST DICER1 SUPT5H	4.78e-05	212	33	4	33853758
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	CCAR1 RIC8B DICER1 NRP2	5.33e-05	218	33	4	19460752
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	SUGP1 SART3 DST LARP1B DICER1 SUPT5H	5.42e-05	723	33	6	34133714
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PCF11 SART3 MACF1 MFAP1 SLC4A1AP DICER1 LSG1 HSPH1	5.84e-05	1487	33	8	33957083
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MACF1 DST DICER1 WASF3	6.02e-05	225	33	4	12168954
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	PCF11 SUGP1 SART3 DICER1 HSPH1	7.59e-05	469	33	5	37314180
Pubmed	Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.	CHRNB2 CHRNB4	7.89e-05	14	33	2	19059502
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	CCAR1 SART3 SMARCC1 MACF1 MFAP1 LARP1B HSPH1	8.67e-05	1153	33	7	29845934
Pubmed	Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.	CHRNB2 CHRNB4	9.10e-05	15	33	2	8838678
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SART3 DICER1 SUPT5H LSG1	9.19e-05	251	33	4	28077445
Pubmed	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.	CHRNB2 CHRNB4	1.04e-04	16	33	2	19259974
Pubmed	MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas.	CHRNB2 CHRNB4	1.18e-04	17	33	2	36897571
Pubmed	Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development.	DICER1 NRP2	1.32e-04	18	33	2	21991391
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP350 CDR2L MACF1 DST LARP1B LSG1	1.42e-04	861	33	6	36931259
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	SART3 MACF1 MFAP1 SUPT5H	1.44e-04	282	33	4	23667531
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRNB2 CHRNB4	1.48e-04	19	33	2	17373692
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	PCF11 SUGP1 CCAR1	1.53e-04	109	33	3	12226669
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	CEP350 SART3 DST DICER1 HSPH1	1.56e-04	547	33	5	37267103
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MACF1 DST	1.64e-04	20	33	2	21689717
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SART3 MFAP1 SLC7A6OS DICER1	1.82e-04	300	33	4	28561026
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SUGP1 SART3 MACF1 DST LSG1 HSPH1	2.20e-04	934	33	6	33916271
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCAR1 SMARCC1 MACF1 DST TNR LSG1	2.59e-04	963	33	6	28671696
Pubmed	UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.	CHRNB2 CHRNB4	2.80e-04	26	33	2	19474315
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SART3 SMARCC1 MACF1 SLC4A1AP SLC7A6OS LSG1 HSPH1	3.06e-04	1415	33	7	28515276
Pubmed	Human transcription factor protein interaction networks.	PCF11 SUGP1 CCAR1 SMARCC1 MFAP1 DST HSPH1	3.25e-04	1429	33	7	35140242
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CEP350 SMARCC1 SUPT5H HSPH1	3.53e-04	357	33	4	37059091
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	SART3 G2E3 TRIM52	3.53e-04	145	33	3	28846114
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CEP350 MACF1 MFAP1 DST DICER1 SUPT5H	3.60e-04	1024	33	6	24711643
Pubmed	Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.	CHRNB2 NRP2	4.25e-04	32	33	2	30936179
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MACF1 DICER1	4.81e-04	34	33	2	25925205
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ANKRD49 SMARCC1 MACF1 SPOCK2 G2E3 HSPH1	4.87e-04	1084	33	6	11544199
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	MFAP1 SLC4A1AP SUPT5H	4.97e-04	163	33	3	22113938
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	SART3 SMARCC1 SUPT5H HSPH1	5.37e-04	399	33	4	37536630
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	PCF11 SMARCC1 SLC4A1AP SUPT5H	5.37e-04	399	33	4	35987950
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CEP350 SUGP1 MFAP1 DICER1 LSG1	5.97e-04	733	33	5	34672954
Interaction	SNRPB interactions	SUGP1 CCAR1 SART3 MACF1 MFAP1 SLC4A1AP SLC7A6OS SUPT5H	1.40e-06	517	33	8	int:SNRPB
Interaction	TERF2IP interactions	PCF11 SUGP1 ANKRD49 CCAR1 SMARCC1 MFAP1 SLC4A1AP SUPT5H	2.28e-06	552	33	8	int:TERF2IP
Interaction	CHRNA2 interactions	CHRNB2 CHRNB4	7.79e-06	3	33	2	int:CHRNA2
Interaction	MECP2 interactions	PCF11 SUGP1 CCAR1 SMARCC1 MACF1 MFAP1 SPOCK2 DST SUPT5H LSG1	2.60e-05	1287	33	10	int:MECP2
Interaction	SNRPB2 interactions	SUGP1 CCAR1 SART3 MFAP1 SLC4A1AP	5.54e-05	255	33	5	int:SNRPB2
Interaction	RAD18 interactions	SUGP1 CCAR1 SART3 SMARCC1 MFAP1 SLC4A1AP	8.67e-05	457	33	6	int:RAD18
Interaction	GSK3A interactions	CEP350 MACF1 DST LARP1B DICER1 LSG1	9.42e-05	464	33	6	int:GSK3A
Interaction	SNRPA interactions	PCF11 SUGP1 CCAR1 SART3 MFAP1 SUPT5H	1.16e-04	482	33	6	int:SNRPA
Interaction	GLDC interactions	CCAR1 SART3 SMARCC1 LARP1B HSPH1	1.64e-04	321	33	5	int:GLDC
Interaction	DHX38 interactions	MACF1 MFAP1 SLC7A6OS SUPT5H	1.65e-04	170	33	4	int:DHX38
Interaction	SIRT7 interactions	CCAR1 SART3 SMARCC1 MACF1 DST DICER1 SUPT5H	1.68e-04	744	33	7	int:SIRT7
Interaction	MOV10 interactions	PCF11 CEP350 ANKRD49 SMARCC1 MACF1 LARP1B DICER1 SUPT5H LSG1	1.73e-04	1297	33	9	int:MOV10
Interaction	CEP290 interactions	CEP350 DST SUPT5H TRIM52	2.01e-04	179	33	4	int:CEP290
Interaction	CEP295 interactions	MFAP1 TRIM52 HSPH1	2.12e-04	71	33	3	int:CEP295
Interaction	NUP50 interactions	SUGP1 SART3 MFAP1 SLC4A1AP SUPT5H	2.17e-04	341	33	5	int:NUP50
Interaction	GOLGA1 interactions	CEP350 MACF1 DST DICER1	2.19e-04	183	33	4	int:GOLGA1
Interaction	NXF1 interactions	PCF11 CEP350 SUGP1 ANKRD49 SMARCC1 MACF1 ZNF761 SUPT5H LSG1	2.28e-04	1345	33	9	int:NXF1
Interaction	SLX4 interactions	CEP350 SUGP1 SMARCC1 MFAP1 SUPT5H HSPH1	2.94e-04	572	33	6	int:SLX4
GeneFamily	EF-hand domain containing\|Plakins	MACF1 DST	3.24e-05	8	20	2	939
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNB2 CHRNB4	1.38e-04	16	20	2	173
GeneFamily	EF-hand domain containing	MACF1 DST	2.40e-02	219	20	2	863
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	CEP350 ANKRD49 CCAR1 SMARCC1 MACF1 G2E3 ZNF761 SLC4A1AP DICER1 HSPH1	1.35e-05	1257	33	10	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	CEP350 ANKRD49 CCAR1 SMARCC1 MACF1 G2E3 ZNF761 SLC4A1AP DICER1 HSPH1	4.88e-05	1459	33	10	facebase_RNAseq_e10.5_Emin_LatNas_2500
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYT16 MACF1 DST NRP2	9.46e-06	181	33	4	beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	MACF1 SPOCK2 TRIM52	1.88e-04	151	33	3	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CDR2L DST MFSD4B	1.99e-04	154	33	3	928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	DST TNR WASF3	2.27e-04	161	33	3	347edb0de10850b7d16c40945751033289289c9b
ToppCell	AT1-AT2_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	SYT16 SPOCK2 WASF3	2.31e-04	162	33	3	57d627259d27f39885bf416d74bcb6656db6e27b
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SPOCK2 DST SUPT5H	2.61e-04	169	33	3	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SPOCK2 DST SUPT5H	2.61e-04	169	33	3	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	G2E3 SLC4A1AP HSPH1	2.80e-04	173	33	3	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	G2E3 SLC4A1AP HSPH1	2.80e-04	173	33	3	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	SPOCK2 DST WASF3	2.85e-04	174	33	3	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACF1 DST NRP2	2.90e-04	175	33	3	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MACF1 SPOCK2 NRP2	2.95e-04	176	33	3	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIC8B CHRNB2 NRP2	2.95e-04	176	33	3	a9e77681bcd36c382d53eb6f771349d55f98d744
ToppCell	AT1-AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	SYT16 SPOCK2 DST	2.95e-04	176	33	3	f86832cfeff5b3cfffe4455c1b96a1420d48ba1e
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPOCK2 DST CHRNB2	3.04e-04	178	33	3	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACF1 DST NRP2	3.04e-04	178	33	3	ad3de3e03a401dac64431a541899445262246347
ToppCell	AT1_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SYT16 SPOCK2 DST	3.09e-04	179	33	3	1603117b52623663458a977c94bf7f9f6c1114b8
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DST HSPH1 NRP2	3.25e-04	182	33	3	53c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNR CHRNB2 CHRNB4	3.35e-04	184	33	3	3e5c68a99c10eb1ddc1048bea4aa9f6b8e2746ff
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPOCK2 DST WASF3	3.35e-04	184	33	3	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNR CHRNB2 CHRNB4	3.35e-04	184	33	3	1e2f0cec50475a1cf2973a5082826bbc60fc9a68
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPOCK2 DST WASF3	3.35e-04	184	33	3	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPOCK2 DST WASF3	3.35e-04	184	33	3	ca940a4f4970285ed284d5517d142abab0682044
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 SMARCC1 MACF1	3.35e-04	184	33	3	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPOCK2 DST WASF3	3.41e-04	185	33	3	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPOCK2 RIC8B NRP2	3.41e-04	185	33	3	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPOCK2 RIC8B NRP2	3.41e-04	185	33	3	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPOCK2 DST WASF3	3.52e-04	187	33	3	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPOCK2 RIC8B NRP2	3.57e-04	188	33	3	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPOCK2 RIC8B NRP2	3.57e-04	188	33	3	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	COPD-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	SPOCK2 DST WASF3	3.63e-04	189	33	3	14e8e57e4db336fbef005270647983b4edf407c0
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST WASF3 NRP2	3.74e-04	191	33	3	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	LAM-Epithelial-AT1\|Epithelial / Condition, Lineage and Cell class	SPOCK2 DST WASF3	3.74e-04	191	33	3	3457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST WASF3 NRP2	3.74e-04	191	33	3	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	DST HVCN1 NRP2	3.74e-04	191	33	3	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST WASF3 NRP2	3.74e-04	191	33	3	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	(11)_FOXN4+-(0)_Reference\|(11)_FOXN4+ / shred by cell type by condition	ZDHHC15 ISM2 TRIM52	3.80e-04	192	33	3	ef06f96b934dd05b40025f8215b6d919d3a17045
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	SPOCK2 DST WASF3	3.80e-04	192	33	3	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	MACF1 DST NRP2	3.80e-04	192	33	3	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MACF1 DST	3.86e-04	193	33	3	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MACF1 DST NRP2	3.86e-04	193	33	3	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	MACF1 DST NRP2	3.86e-04	193	33	3	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MACF1 DST	3.86e-04	193	33	3	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	CEP350 SMARCC1 G2E3	3.86e-04	193	33	3	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MACF1 DST	3.86e-04	193	33	3	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MACF1 DST	3.86e-04	193	33	3	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	368C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST NRP2	3.92e-04	194	33	3	d9eec28fa7b255c0ec023276dd955f1e276e7159
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPOCK2 DST NRP2	3.92e-04	194	33	3	43eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCell	368C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MACF1 DST NRP2	3.92e-04	194	33	3	e4d7e9709ce42d4610e44d3445927eefbcbb9eff
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CDR2L WASF3 NRP2	3.92e-04	194	33	3	8a4be91414a2e69dd410aa75791f16008204c9a1
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MACF1 DST NRP2	3.92e-04	194	33	3	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCF11 SPOCK2 DST	3.97e-04	195	33	3	f41a68b7c2621594db8d8952e301eeadc96be26f
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MACF1 SPOCK2 HSPH1	4.03e-04	196	33	3	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	(7)_Epithelial-I_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	SYT16 SPOCK2 DST	4.03e-04	196	33	3	150554fa06868d29b0608189862eef6505ba757f
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPOCK2 DST WASF3	4.03e-04	196	33	3	6856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPOCK2 DST WASF3	4.03e-04	196	33	3	6731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SPOCK2 DST WASF3	4.09e-04	197	33	3	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CEP350 CCAR1 MFAP1	4.09e-04	197	33	3	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	AT1_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CDR2L SPOCK2 DST	4.09e-04	197	33	3	80d81be244c94c435accb643449b4ce6a3462c7f
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	SPOCK2 DST WASF3	4.16e-04	198	33	3	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DST HSPH1 NRP2	4.16e-04	198	33	3	ff9c97c6f579a4e79859d420f224556fadc1f6ab
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	MACF1 DST NRP2	4.16e-04	198	33	3	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	MACF1 SPOCK2 DST	4.22e-04	199	33	3	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	Sigmoid-(3)_ILC\|Sigmoid / shred on region, Cell_type, and subtype	CDR2L SPOCK2 TNR	4.28e-04	200	33	3	a7326c43987a5eb4f4f5b48c4252cf4870432e5d
ToppCell	Sigmoid-(3)_ILC-(30)_ILC\|Sigmoid / shred on region, Cell_type, and subtype	CDR2L SPOCK2 TNR	4.28e-04	200	33	3	c39de94623383da7b2b260eb016ddaa5da7f4350
ToppCell	Sigmoid-ILC-ILC\|Sigmoid / Region, Cell class and subclass	CDR2L SPOCK2 TNR	4.28e-04	200	33	3	4ac1e6d7f358003e2448eb69e545772cd261c55f
ToppCell	Biopsy_Control_(H.)-Epithelial-AT1\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SPOCK2 DST WASF3	4.28e-04	200	33	3	3a9633f5913f12b6865fc777c84f3f3ba795a78d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Interneuron\|1m / Sample Type, Dataset, Time_group, and Cell type.	CEP350 DST CHRNB2	4.28e-04	200	33	3	fc839e9c33ea1d4ee0f42f21fd32a54e7cbe1f5a
ToppCell	Sigmoid-ILC\|Sigmoid / Region, Cell class and subclass	CDR2L SPOCK2 TNR	4.28e-04	200	33	3	dfb06821f1019833f5d81f9c93808219b5fef407
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SPOCK2 DST HSPH1	4.28e-04	200	33	3	d9e8a0d047d4403fb7265fde7448e23a7780785c
Computational	Genes upregulated in subsets of cells of a given type within various tumors	CEP350 MACF1 DST	1.57e-04	50	23	3	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Computational	Neighborhood of ERBB2IP	CEP350 MACF1 DICER1	3.43e-04	65	23	3	GCM_ERBB2IP
Drug	1,2-bis-N-cytisinylethane	CHRNB2 CHRNB4	6.11e-06	3	33	2	ctd:C482518
Drug	Anabasine	CHRNB2 CHRNB4	1.22e-05	4	33	2	ctd:D000691
Drug	2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane	CHRNB2 CHRNB4	1.22e-05	4	33	2	ctd:C569671
Drug	N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline	CHRNB2 CHRNB4	2.03e-05	5	33	2	ctd:C524978
Drug	cisatracurium	CHRNB2 CHRNB4	2.03e-05	5	33	2	ctd:C101584
Drug	decamethonium	CHRNB2 CHRNB4	3.04e-05	6	33	2	ctd:C033019
Drug	mivacurium	CHRNB2 CHRNB4	4.26e-05	7	33	2	ctd:C049430
Drug	EPTC	CHRNB2 CHRNB4	4.26e-05	7	33	2	ctd:C036251
Drug	Atracurium	CHRNB2 CHRNB4	4.26e-05	7	33	2	ctd:D001279
Drug	Dimethylphenylpiperazinium Iodide	CHRNB2 CHRNB4	5.67e-05	8	33	2	ctd:D004246
Drug	epibatidine	CHRNB2 CHRNB4	5.67e-05	8	33	2	ctd:C082748
Drug	fenoxycarb	CHRNB2 CHRNB4	7.29e-05	9	33	2	ctd:C052034
Drug	cytisine	CHRNB2 CHRNB4	1.11e-04	11	33	2	ctd:C004712
Drug	Pancuronium	CHRNB2 CHRNB4	1.11e-04	11	33	2	ctd:D010197
Drug	Dihydro-beta-Erythroidine	CHRNB2 CHRNB4	1.11e-04	11	33	2	ctd:D004079
Drug	rocuronium	CHRNB2 CHRNB4	1.11e-04	11	33	2	ctd:C061870
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A	CEP350 SART3 SMARCC1 DICER1	1.24e-04	178	33	4	3998_DN
Drug	staurosporine; Down 200; 1uM; MCF7; HG-U133A	CEP350 CDR2L ANKRD49 SART3	1.32e-04	181	33	4	312_DN
Drug	Vecuronium Bromide	CHRNB2 CHRNB4	1.33e-04	12	33	2	ctd:D014673
Drug	tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA	CEP350 ANKRD49 SART3 DICER1	1.44e-04	185	33	4	1114_DN
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	CEP350 SART3 SMARCC1 DICER1	1.53e-04	188	33	4	6735_DN
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	CEP350 SART3 SMARCC1 DICER1	1.72e-04	194	33	4	4361_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A	SUGP1 SMARCC1 SPOCK2 DICER1	1.72e-04	194	33	4	4319_DN
Drug	Pergolide mesylate [66104-23-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	CEP350 SUGP1 RIC8B TRIM52	1.76e-04	195	33	4	7434_UP
Drug	Cefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; HL60; HT_HG-U133A	CEP350 SUGP1 SART3 SMARCC1	1.76e-04	195	33	4	6159_DN
Drug	Cyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	CEP350 CDR2L SMARCC1 MACF1	1.83e-04	197	33	4	5340_DN
Drug	Varenicline	CHRNB2 CHRNB4	1.83e-04	14	33	2	ctd:D000068580
Drug	Proglumide [6620-60-6]; Up 200; 12uM; PC3; HT_HG-U133A	SUGP1 SPOCK2 DICER1 CHRNB2	1.90e-04	199	33	4	4337_UP
Drug	Hexamethonium	CHRNB2 CHRNB4	2.41e-04	16	33	2	ctd:D018738
Disease	Seizures	MACF1 CHRNB4 NRP2	1.68e-03	218	32	3	C0036572
Disease	Withdrawal Symptoms	CHRNB2 CHRNB4	1.81e-03	58	32	2	C0087169
Disease	Drug Withdrawal Symptoms	CHRNB2 CHRNB4	1.81e-03	58	32	2	C0086189
Disease	Substance Withdrawal Syndrome	CHRNB2 CHRNB4	1.81e-03	58	32	2	C0038587
Disease	cancer (implicated_via_orthology)	SMARCC1 MACF1 DST	3.02e-03	268	32	3	DOID:162 (implicated_via_orthology)
Disease	nicotine dependence	CHRNB2 CHRNB4	3.25e-03	78	32	2	EFO_0003768
Disease	Visual seizure	CHRNB4 NRP2	5.38e-03	101	32	2	C0270824
Disease	Epileptic drop attack	CHRNB4 NRP2	5.38e-03	101	32	2	C0270846
Disease	Generalized seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C0234533
Disease	Clonic Seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C0234535
Disease	Vertiginous seizure	CHRNB4 NRP2	5.38e-03	101	32	2	C0422855
Disease	Gustatory seizure	CHRNB4 NRP2	5.38e-03	101	32	2	C0422854
Disease	Seizures, Somatosensory	CHRNB4 NRP2	5.38e-03	101	32	2	C0422850
Disease	Olfactory seizure	CHRNB4 NRP2	5.38e-03	101	32	2	C0422853
Disease	Seizures, Auditory	CHRNB4 NRP2	5.38e-03	101	32	2	C0422852
Disease	Generalized Absence Seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C4505436
Disease	Convulsive Seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C0751494
Disease	Seizures, Sensory	CHRNB4 NRP2	5.38e-03	101	32	2	C0751496
Disease	Atonic Absence Seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C0751123
Disease	Complex partial seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C0149958
Disease	Single Seizure	CHRNB4 NRP2	5.38e-03	101	32	2	C0751110
Disease	Epileptic Seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C4317109
Disease	Jacksonian Seizure	CHRNB4 NRP2	5.38e-03	101	32	2	C0022333
Disease	Non-epileptic convulsion	CHRNB4 NRP2	5.38e-03	101	32	2	C0751056
Disease	Nonepileptic Seizures	CHRNB4 NRP2	5.38e-03	101	32	2	C3495874

Protein segments in the cluster

Peptide	Gene	Start	Entry
DDEDQSVVEDWKYVA	CHRNB4	441	P30926
SAEEEESWYDQQDLE	CDR2L	11	Q86X02
KDDDETEEDNNQDEY	CCAR1	856	Q8IX12
QDNYVSWSDSEDDDE	DICER1	406	Q9UPY3
NTDDENDEEEYEAWK	MFAP1	266	P55081
EYEDCPEEEEDDWQT	LSG1	306	Q9H089
NEKEEEEVAYDWSER	DST	716	Q03001
NYKKWENEEEEEEEE	HVCN1	41	Q96D96
ETEDWLYEEGEDQAK	HSPH1	671	Q92598
EDKEEDEEEQALWFN	ISM2	286	Q6H9L7
EDEIDDEYEVDWSNS	NRP2	826	O60462
EDEEQDDKNEEWYRL	ANKRD49	51	Q8WVL7
LNEKEEEELAYDWSD	MACF1	696	Q9UPN3
EYEEENEEEDAEKWN	MFSD4B	436	Q5TF39
NEEEDAEKWNEMDFE	MFSD4B	441	Q5TF39
CQEQFEQYWDEEEEE	PCF11	1446	O94913
EQYWDEEEEEWHLKN	PCF11	1451	O94913
EKDASWELEENAYQE	G2E3	211	Q7L622
ELHEEEAQWVNYDED	CEP350	3066	Q5VT06
GEYEWEYDEEEEKNQ	SART3	81	Q15020
WSDNDSDYEIDDQDL	LARP1B	431	Q659C4
YFEDEEQDNDWSQED	SYT16	66	Q17RD7
WYSEDEDTDTEEYKN	RIC8B	466	Q9NVN3
DVDDEYEDEDQWEDG	SUPT5H	81	O00267
FNEWMNEEDYEVDEN	SMARCC1	276	Q92922
EDDDQSVSEDWKYVA	CHRNB2	441	P17787
FQSPDEDEEEDYEQW	SUGP1	161	Q8IWZ8
EDEEEDYEQWLEIKV	SUGP1	166	Q8IWZ8
IYDDEDDENSENNWR	SLC7A6OS	236	Q96CW6
NVDYMWDEEEEEEEE	TRIM52	116	Q96A61
DKDIHDYEFQWQEDE	ZNF761	91	Q86XN6
YSDSDDDSEFDENDW	WASF3	486	Q9UPY6
DLEWDNSEAEVQEYK	TNR	611	Q92752
EDDYIKSWEDNQQGD	SPOCK2	66	Q92563
EETWEDNEDDNQDYP	ZDHHC15	311	Q96MV8
KNWEDEDFYDSDDDT	SLC4A1AP	456	Q9BWU0