Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	MFS_dom	SLC17A1 SLC49A4 UNC93A SLC46A1 MFSD13A MFSD12	1.40e-05	134	73	6	IPR020846
Domain	CAPS	CADPS CADPS2	1.51e-05	2	73	2	IPR033227
Domain	DUF1041	CADPS CADPS2	1.50e-04	5	73	2	SM01145
Domain	DUF1041	CADPS CADPS2	3.12e-04	7	73	2	PF06292
Domain	Munc13_1	CADPS CADPS2	3.12e-04	7	73	2	IPR014770
Domain	CAPS_dom	CADPS CADPS2	3.12e-04	7	73	2	IPR010439
Domain	MHD1	CADPS CADPS2	3.12e-04	7	73	2	PS51258
Domain	MFS	SLC17A1 SLC49A4 SLC46A1 MFSD12	8.47e-04	108	73	4	PS50850
Domain	MFS_1	SLC17A1 SLC46A1 MFSD12	3.41e-03	77	73	3	PF07690
Domain	MFS	SLC17A1 SLC46A1 MFSD12	3.41e-03	77	73	3	IPR011701
Domain	PH	PLEKHG4B ELMO3 CADPS ARHGEF3 CADPS2	4.64e-03	278	73	5	SM00233
Domain	PH_DOMAIN	PLEKHG4B ELMO3 CADPS ARHGEF3 CADPS2	4.71e-03	279	73	5	PS50003
Domain	PH_domain	PLEKHG4B ELMO3 CADPS ARHGEF3 CADPS2	4.79e-03	280	73	5	IPR001849
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	ADRA2B GPR143 HRH4 TAAR5	1.31e-05	42	49	4	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	ADRA2B GPR143 HRH4 TAAR5	1.31e-05	42	49	4	MM14971
Pubmed	CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.	CADPS CADPS2	4.47e-06	2	74	2	18177725
Pubmed	CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.	CADPS CADPS2	4.47e-06	2	74	2	18022372
Pubmed	CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.	CADPS CADPS2	4.47e-06	2	74	2	18495893
Pubmed	CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.	CADPS CADPS2	4.47e-06	2	74	2	28883501
Pubmed	CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.	CADPS CADPS2	4.47e-06	2	74	2	25719439
Pubmed	Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.	CADPS CADPS2	4.47e-06	2	74	2	20855507
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	PLEKHG4B WDR90 CSMD1 TM6SF2	1.02e-05	63	74	4	11572484
Pubmed	Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.	CADPS CADPS2	1.34e-05	3	74	2	12659812
Pubmed	An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells.	CADPS CADPS2	1.34e-05	3	74	2	30389842
Pubmed	A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.	CADPS CADPS2	1.34e-05	3	74	2	14530279
Pubmed	Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.	CADPS CADPS2	1.34e-05	3	74	2	25437547
Pubmed	Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.	CADPS CADPS2	1.34e-05	3	74	2	19008227
Pubmed	Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.	CADPS CADPS2	2.67e-05	4	74	2	19238500
Pubmed	Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.	CADPS CADPS2	2.67e-05	4	74	2	29068313
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	BTNL3 TMEM178A PGAP1 LYZL6 GPR78 CTHRC1 CSMD1 ITGA7 MFSD13A VMO1	4.42e-05	985	74	10	12975309
Pubmed	Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.	CADPS CADPS2	4.45e-05	5	74	2	22111578
Pubmed	N-Glycans in the gp120 V1/V2 domain of the HIV-1 strain NL4-3 are indispensable for viral infectivity and resistance against antibody neutralization.	GANC GBA2	6.66e-05	6	74	2	16547752
Pubmed	Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity.	GANC GBA2	6.66e-05	6	74	2	1704656
Pubmed	SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling.	CD8A SOCS1	6.66e-05	6	74	2	16357940
Pubmed	Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design.	GANC GBA2	6.66e-05	6	74	2	12719582
Pubmed	Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.	GANC GBA2	6.66e-05	6	74	2	2959866
Pubmed	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.	CADPS CADPS2	6.66e-05	6	74	2	28635948
Pubmed	Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding.	GANC GBA2	9.31e-05	7	74	2	2076345
Pubmed	AIDS and glycosylation.	GANC GBA2	9.31e-05	7	74	2	2136376
Pubmed	Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.	GGH SLC46A1	9.31e-05	7	74	2	18842806
Pubmed	Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain.	CADPS CADPS2	1.24e-04	8	74	2	16506193
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	CADPS CADPS2	1.24e-04	8	74	2	25609709
Pubmed	Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6.	EGR4 SEC13	1.24e-04	8	74	2	7987303
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	PGS1 YIPF1 PPP1R12A ADGRB2 APEH WDR90 ARHGEF3 ABCC10 KPNA1	1.51e-04	925	74	9	28986522
Pubmed	CAPS1 regulates catecholamine loading of large dense-core vesicles.	CADPS CADPS2	1.99e-04	10	74	2	15820695
Pubmed	The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.	CADPS CADPS2	1.99e-04	10	74	2	14715936
Pubmed	SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.	CADPS CADPS2	1.99e-04	10	74	2	21040848
Pubmed	The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.	CADPS CADPS2	2.43e-04	11	74	2	25374362
Pubmed	A Pellino-2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium-digital keloid dysplasia.	CCNF PELI2	4.00e-04	14	74	2	36776133
Pubmed	Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization.	CCNF PELI2	4.00e-04	14	74	2	34674267
Pubmed	Quantitative trait loci for steady-state platelet count in mice.	SLC46A1 ABCA8	4.61e-04	15	74	2	15520881
Pubmed	LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line.	SLC46A1 ABCC10	4.61e-04	15	74	2	28112518
Pubmed	Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.	ADRA2B CD8A EGR4	4.76e-04	71	74	3	8751373
Pubmed	Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.	FLT4 ADRA2B	5.95e-04	17	74	2	17673674
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	GANC GBA2	5.95e-04	17	74	2	2355006
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR150 ADGRB2 GRM2	6.51e-04	79	74	3	12679517
Pubmed	Lymph sacs are not required for the initiation of lymph node formation.	FLT4 CD8A	7.46e-04	19	74	2	19060331
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	GANC GBA2	8.28e-04	20	74	2	12560567
Pubmed	Report of the sixth international workshop on human chromosome 3 mapping 1995.	APEH SEC13	9.14e-04	21	74	2	8641130
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	GANC GBA2	1.00e-03	22	74	2	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	GANC GBA2	1.00e-03	22	74	2	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	GANC GBA2	1.00e-03	22	74	2	11530211
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCA8 ABCC10	1.10e-03	23	74	2	10708515
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	GANC GBA2	1.10e-03	23	74	2	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	GANC GBA2	1.10e-03	23	74	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	GANC GBA2	1.10e-03	23	74	2	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	GANC GBA2	1.10e-03	23	74	2	3264072
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	GANC GBA2	1.30e-03	25	74	2	2283726
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	GANC GBA2	1.40e-03	26	74	2	8218172
Pubmed	Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.	GGH GPR143	1.75e-03	29	74	2	12643545
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	C2 C1QTNF7	2.00e-03	31	74	2	19344414
ToppCell	Skin-Fibroblasts\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	CADPS CTHRC1 LHFPL2 C1QTNF7 ABCA8 CREB3L1	1.12e-06	200	75	6	f777eadf571a1a6d246da87346a9cb9d511c2e81
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PLEKHG4B FLT4 GPR150 CADPS CTHRC1	7.54e-06	160	75	5	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	Mild-MAIT\|Mild / Disease group and Cell class	FLT4 YIPF1 GPR150 TLE1 NYNRIN	7.77e-06	161	75	5	0c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	PLEKHG4B EGR4 CTHRC1 LHFPL2 STK31	8.50e-06	164	75	5	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ELMO3 PGAP1 SLC49A4 GEMIN5 SOCS1	1.01e-05	170	75	5	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-T_cells-CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD8A EGR4 ADGRB2 SOCS1 ARHGEF3	1.82e-05	192	75	5	c1e2a7df7809696c482442665af5c6bb2f0e5bea
Disease	ubiquitin-like protein ISG15 measurement	C2 ARHGEF3	9.00e-05	6	73	2	EFO_0021875
Disease	thioredoxin domain-containing protein 12 measurement	APEH ARHGEF3 GRM2	1.25e-04	39	73	3	EFO_0008298
Disease	arylsulfatase K measurement	GPR150 ARHGEF3	1.67e-04	8	73	2	EFO_0801395
Disease	semaphorin-3A measurement	SLC46A1 RSKR	6.21e-04	15	73	2	EFO_0008278
Disease	age-related hearing impairment	GPR6 ADGRB2 CSMD1 ABCC10 RSKR	1.26e-03	324	73	5	EFO_0005782
Disease	ubiquitin carboxyl-terminal hydrolase 25 measurement	C2 ARHGEF3	1.35e-03	22	73	2	EFO_0021881
Disease	vitronectin measurement	SLC46A1 RSKR	1.48e-03	23	73	2	EFO_0021843
Disease	QRS duration, response to sulfonylurea	CSMD1 COQ2	1.48e-03	23	73	2	EFO_0005055, EFO_0007922
Disease	economic and social preference	CADPS LHFPL2 C2	1.81e-03	97	73	3	EFO_0004827
Disease	lipoprotein measurement	PGS1 TM6SF2 ABCA8	2.27e-03	105	73	3	EFO_0004732
Disease	Strabismus	CADPS CSMD1	2.35e-03	29	73	2	HP_0000486

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYCWLSLEGGLLYAF	ADGRB2	1066	O60241
PSDIGLYGCWFSSQI	BTNL3	106	Q6UXE8
PSRSLLFYDDGAGLW	CREB3L1	421	Q96BA8
LVGWLPCLSSYDSYC	ARHGEF3	201	Q9NR81
LSCSPGYYLEGWRLL	CSMD1	2586	Q96PZ7
RWYFTFNGAECSGPL	CTHRC1	156	Q96CG8
GLGYWPNASLTGCFE	GRM2	541	Q14416
WYILASSIGSFFAPC	ADRA2B	171	P18089
GLDFACDIYIWAPLA	CD8A	176	P01732
LWYFYSALPRGLGCS	ALG12	261	Q9BV10
DSYSCLGWFSPGQVF	CADPS	696	Q9ULU8
YAWLAPLLARGACGE	ABCC10	226	Q5T3U5
SIGLAAEPGCFPDWY	COQ2	96	Q96H96
PLCWDSKLIGYGSAA	SLC46A1	296	Q96NT5
GTFGASWLPFAIYCV	GPR6	286	P46095
LDGFEGYSLSDWLCL	LYZL6	36	O75951
GTDPACYEFLWGPRA	MAGEA11	376	P43364
LVSWGLYNPCLGSAD	C2	696	P06681
AKGLWLYLAGSSLPC	PGS1	466	Q32NB8
DFEGVCWPGLSSYLD	GANC	466	Q8TET4
LYSLWSAVGCFPEAS	RSKR	191	Q96LW2
ASAYKPGDCSLGWAF	LHFPL2	171	Q6ZUX7
PGDCSLGWAFYTAIG	LHFPL2	176	Q6ZUX7
YPGAGDFLSWALNSC	EGR4	146	Q05215
AEWPGYLSHLCGRSA	PNPO	16	Q9NVS9
AFSGAALGCSWLGYS	GPR78	136	Q96P69
WCLFGDGAFGYSLIE	ILVBL	516	A1L0T0
LGSFLDWSLDCCSGY	CCNF	601	P41002
TTGPSAYCGGLWLAA	GBA2	681	Q9HCG7
SFDDGDYFPVWGTCL	GGH	121	Q92820
ALAYAIPLGVFAGWS	SLC49A4	286	Q96SL1
LSLAFYGWTGCSLGF	GPR143	306	P51810
WLPGEPNDSGFCAYL	ATRNL1	836	Q5VV63
DSYSCLGWFSPGQVF	CADPS2	661	Q86UW7
FYLWTDGLSALLGSP	ELMO3	651	Q96BJ8
VDGCYSFWQAGLLPL	FNTB	296	P49356
SRDPWGASGICYLFG	ITGA7	6	Q13683
ACGWLSAIGFFQYSP	SCAMP4	131	Q969E2
TFAPLLGTWLLCFYT	MFSD13A	416	Q14CX5
LGCGAATPEWAALLY	MFSD12	116	Q6NUT3
PGWADSLFSGFLLYV	C1QTNF7	261	Q9BXJ2
CGYLTWHSGLAAFPA	FAM8A1	126	Q9UBU6
DEWCAGFGLYVLSPT	NYNRIN	1321	Q9P2P1
YPIWGAVFFCSSGTL	MS4A3	91	Q96HJ5
YWTFAGGCESLLDLF	FOXL3	106	A0A1W2PRP0
GSECEPGFFSEWYIL	HRH4	161	Q9H3N8
WAPHDYGLILACGSS	SEC13	111	P55735
LAGWGVPAAYTSLFL	TAAR5	156	O14804
AECGRPLFATYSGLW	TMEM178A	101	Q8NBL3
LADACWALSYLSDGP	KPNA1	271	P52294
PLWLGCEAGFYVDAG	PELI2	346	Q9HAT8
GCELPYFAARLAAAW	GPR150	306	Q8NGU9
GFLSSLPYLFAWICG	SLC17A1	301	Q14916
LFLFGTCTAYWSGLL	PGAP1	686	Q75T13
PLWCRGGAYLVAFSL	VMO1	111	Q7Z5L0
AALCLLWYALSAGGN	SLC35E1	31	Q96K37
SALLDACGFYWGPLS	SOCS1	71	O15524
ALPAAAWSLYQAGCS	RIOX1	281	Q9H6W3
FSGIYCSLLPLGCWS	APEH	356	P13798
WGCLGFTSLYRHLPA	ABCA8	341	O94911
SPGSDLYAYGCLLLW	STK31	906	Q9BXU1
LPYLLFDWSGTGRAD	ULBP3	16	Q9BZM4
FSLGYCPTGEWLAVG	TLE1	661	Q04724
SLAAFCPWDGALLMY	WDR90	1636	Q96KV7
SNPDLYGPFWICATL	YIPF1	116	Q9Y548
WSAGYFSALSRGDPL	ROPN1L	41	Q96C74
LDGSFPYSHGDWICF	PLEKHG4B	331	Q96PX9
FSSFTIDLPWGGCYH	SLC6A13	141	Q9NSD5
YNWVSFPGCLARGAE	FLT4	1231	P35916
CSWTLPSLGGFAYSL	GEMIN5	371	Q8TEQ6
GLGAAPLWSAQCTYL	UNC93A	101	Q86WB7
GLAAYALTFPGCSWL	TM6SF2	281	Q9BZW4
WDLGNYSVLCSGALG	VSIG10L	646	Q86VR7
GFFLGSCSSLDPCLW	GARIN5B	326	Q8N5Q1
TCASPPGLAGRYFWA	LRFN4	256	Q6PJG9
GWIPLHAAASCGYLD	PPP1R12A	106	O14974