Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainTRC8_N

RNF145 RNF139

6.93e-0521562PF13705
DomainClathrin_H-chain_propeller_rpt

CLTCL1 CLTC

6.93e-0521562IPR022365
DomainClathrin-link

CLTCL1 CLTC

6.93e-0521562PF09268
Domain-

CLTCL1 CLTC

6.93e-05215622.130.10.110
DomainClathrin_heavy_chain

CLTCL1 CLTC

6.93e-0521562IPR016341
DomainClathrin_H-chain_propeller_N

CLTCL1 CLTC

6.93e-0521562IPR001473
DomainTRC8_N_dom

RNF145 RNF139

6.93e-0521562IPR025754
DomainClathrin_H-chain_link/propller

CLTCL1 CLTC

6.93e-0521562IPR016025
DomainClathrin_propel

CLTCL1 CLTC

6.93e-0521562PF01394
DomainClathrin_H-chain_linker_core

CLTCL1 CLTC

6.93e-0521562IPR015348
DomainPax2_C

PAX2 PAX5

2.07e-0431562IPR022130
DomainClathrin_H-chain_linker

CLTCL1 CLTC

2.07e-0431562IPR012331
DomainPax2_C

PAX2 PAX5

2.07e-0431562PF12403
DomainCLH

CLTCL1 CLTC

2.07e-0431562SM00299
DomainA/G_cyclase_CS

NPR2 ADCY3 GUCY2F

3.57e-04171563IPR018297
DomainRetinoicA-induced_16-like

FHIP1A FHIP2B

4.11e-0441562IPR019384
DomainRAI16-like

FHIP1A FHIP2B

4.11e-0441562PF10257
Domain-

NPR2 ADCY3 GUCY2F

4.25e-041815633.30.70.1230
DomainNucleotide_cyclase

NPR2 ADCY3 GUCY2F

4.25e-04181563IPR029787
DomainGuanylate_cyc

NPR2 ADCY3 GUCY2F

5.02e-04191563PF00211
DomainGUANYLATE_CYCLASE_2

NPR2 ADCY3 GUCY2F

5.02e-04191563PS50125
DomainA/G_cyclase

NPR2 ADCY3 GUCY2F

5.02e-04191563IPR001054
DomainGUANYLATE_CYCLASE_1

NPR2 ADCY3 GUCY2F

5.02e-04191563PS00452
DomainCYCc

NPR2 ADCY3 GUCY2F

5.02e-04191563SM00044
DomainAmmonium_transpt

RHCE RHD

6.82e-0451562IPR001905
DomainCyt_P450_E_grp-II

CYP3A7 CYP3A5

6.82e-0451562IPR002402
DomainAmmonium_transp

RHCE RHD

6.82e-0451562PF00909
DomainNH4_transpt_AmtB-like_dom

RHCE RHD

6.82e-0451562IPR024041
DomainRhesusRHD

RHCE RHD

6.82e-0451562IPR002229
DomainSpectrin

ACTN2 SPTBN4 DMD

8.95e-04231563PF00435
DomainACTININ_2

ACTN2 SPTBN4 DMD

8.95e-04231563PS00020
DomainACTININ_1

ACTN2 SPTBN4 DMD

8.95e-04231563PS00019
DomainActinin_actin-bd_CS

ACTN2 SPTBN4 DMD

8.95e-04231563IPR001589
DomainCyt_P450_E_CYP3A

CYP3A7 CYP3A5

1.02e-0361562IPR008072
DomainCLTH

RMND5A MAEA

1.02e-0361562PF10607
DomainCRA

RMND5A MAEA

1.02e-0361562SM00757
DomainCTLH/CRA

RMND5A MAEA

1.02e-0361562IPR024964
DomainCRA_dom

RMND5A MAEA

1.02e-0361562IPR013144
DomainClathrin

CLTCL1 CLTC

1.42e-0371562PF00637
DomainTRPC_channel

TRPC1 TRPM2

1.42e-0371562IPR002153
Domain-

RHCE RHD

1.42e-03715621.10.3430.10
DomainAmmonium/urea_transptr

RHCE RHD

1.42e-0371562IPR029020
DomainCHCR

CLTCL1 CLTC

1.42e-0371562PS50236
Domain-

PRAMEF10 LRRK2 LRRC10 PRAMEF1 FBXL6 TLR10 LRRN3 LRRN2 NLRP8

1.54e-0332115693.80.10.10
Domain-

TBC1D9B SPARC EFCAB6 ACTN2 TBC1D8B STAT4 DMD PLCH1

1.60e-0326115681.10.238.10
DomainL_dom-like

PRAMEF10 LRRK2 LRRC10 PRAMEF1 FBXL6 TLR10 LRRN3 LRRN2 NLRP8

1.78e-033281569IPR032675
DomainSpectrin_repeat

ACTN2 SPTBN4 DMD

1.78e-03291563IPR002017
DomainClathrin_H-chain/VPS_repeat

CLTCL1 CLTC

1.88e-0381562IPR000547
DomainARM-type_fold

GBF1 CLTCL1 LRRK2 FRYL USP9Y TRRAP FOCAD CLTC TAF2

2.22e-033391569IPR016024
DomainSPEC

ACTN2 SPTBN4 DMD

2.37e-03321563SM00150
DomainSpectrin/alpha-actinin

ACTN2 SPTBN4 DMD

2.37e-03321563IPR018159
DomainPAX

PAX2 PAX5

2.40e-0391562SM00351
DomainPAIRED_2

PAX2 PAX5

2.40e-0391562PS51057
DomainPAIRED_1

PAX2 PAX5

2.40e-0391562PS00034
DomainCTLH

RMND5A MAEA

2.40e-0391562SM00668
DomainPaired_dom

PAX2 PAX5

2.40e-0391562IPR001523
DomainPAX

PAX2 PAX5

2.40e-0391562PF00292
DomainEF-hand-dom_pair

TBC1D9B SPARC EFCAB6 ACTN2 TBC1D8B STAT4 DMD PLCH1

2.89e-032871568IPR011992
DomainCTLH_C

RMND5A MAEA

2.99e-03101562IPR006595
DomainCTLH

RMND5A MAEA

2.99e-03101562PS50897
DomainTyr_kinase_rcpt_2_CS

DDR1 ALK

3.63e-03111562IPR002011
DomainWHTH_DNA-bd_dom

IRF1 FOXR2 STN1 ELK1 PAX2 PAX5 DEPDC1B

4.28e-032421567IPR011991
DomainRECEPTOR_TYR_KIN_II

DDR1 ALK

4.33e-03121562PS00239
DomainPeptidase_M1_N

ANPEP TAF2

5.09e-03131562IPR014782
DomainPeptidase_M1

ANPEP TAF2

5.09e-03131562PF01433
DomainCyt_P450_E_grp-I

CYP3A7 CYP3A5 CYP17A1

6.27e-03451563IPR002401
Domain-

MRM1 ETF1

6.78e-031515623.30.1330.30
DomainL30e-like

MRM1 ETF1

6.78e-03151562IPR029064
DomainWW

WWP2 PLEKHA5 DMD

7.08e-03471563PF00397
DomainWW

WWP2 PLEKHA5 DMD

7.51e-03481563SM00456
DomainGRAM

TBC1D9B TBC1D8B

7.70e-03161562SM00568
DomainLeu-rich_rpt

LRRK2 LRRC10 FBXL6 TLR10 LRRN3 LRRN2 NLRP8

7.82e-032711567IPR001611
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

SART3 ZSWIM8 ZNF573 CLTCL1 ANPEP ATG7 MYO9A POLD1 ELOVL1 SEC31A VARS2 TNFRSF10A ADCY3 NUBP2 FBXL6 NEU1 YIPF1 INTS11

2.99e-079251601828986522
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ABCA2 TBC1D9B GBF1 CLTCL1 KIF26A TMEM94 PIEZO1 MAEA HECTD4 FRYL CORO1B TRRAP DUS1L FANCA CCDC142 FOCAD INTS11 PAX2 ARHGAP33

8.84e-0711051601935748872
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

SART3 ZSWIM8 TBC1D9B RNF31 POLD1 WWP2 PEX1 ESYT2 DMD DEPDC1B

2.09e-063131601038270169
Pubmed

Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X.

TRPC1 GRPR PIGA GUCY2F

4.27e-062416049722956
Pubmed

Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.

RHCE RHD ZNF18 RSPH3 RNF145

4.65e-0653160516964442
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

GBF1 TRRAP NUBP2 FANCA ESYT2 VPS52

9.03e-06104160631240132
Pubmed

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

CLTCL1 SEC31A CLTC

1.53e-0511160329604273
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

COG2 PRAMEF33 SPARC GBF1 PRAMEF10 CYP3A5 MYO9A MRM1 ELP1 IRF1 FRYL PRAMEF1 TRRAP RHCE RHD YIPF1 FHIP1A DOP1B

1.80e-0512421601830973865
Pubmed

Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region.

RHCE RHD

2.10e-05216028188244
Pubmed

GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells.

GRPR ELK1

2.10e-052160212409226
Pubmed

Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate.

ATG7 IRF1

2.10e-052160225576084
Pubmed

Stretch-activated calcium channel protein TRPC1 is correlated with the different degrees of the dystrophic phenotype in mdx mice.

TRPC1 DMD

2.10e-052160221900691
Pubmed

DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule.

RHCE RHD

2.10e-052160217900276
Pubmed

RHD and RHCE molecular analysis in weak D blood donors and in patients with Rh antibodies against their own corresponding Rh antigen.

RHCE RHD

2.10e-052160232697929
Pubmed

Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an antioxidative-independent mechanism.

NFE2L2 DMD

2.10e-052160230070693
Pubmed

Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.

NFE2L2 DMD

2.10e-052160226494449
Pubmed

Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes.

ATG7 NFE2L2

2.10e-052160225290687
Pubmed

Review: the molecular basis of the Rh blood group phenotypes.

RHCE RHD

2.10e-052160215373666
Pubmed

Intron 4 of the RH Gene in Han Chinese, Tibetan, and Mongol Populations.

RHCE RHD

2.10e-052160226579938
Pubmed

Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.

RHCE RHD

2.10e-052160234968422
Pubmed

Regarding the size of Rh proteins.

RHCE RHD

2.10e-05216021898705
Pubmed

PCR screening for common weak D types shows different distributions in three Central European populations.

RHCE RHD

2.10e-052160211161244
Pubmed

RH diversity in Mali: characterization of a new haplotype RHD*DIVa/RHCE*ceTI(D2).

RHCE RHD

2.10e-052160225857637
Pubmed

The low-prevalence Rh antigen STEM (RH49) is encoded by two different RHCE*ce818T alleles that are often in cis to RHD*DOL.

RHCE RHD

2.10e-052160222738288
Pubmed

Multiple Rh messenger RNA isoforms are produced by alternative splicing.

RHCE RHD

2.10e-05216021379850
Pubmed

Characterization of the mouse Rh blood group gene.

RHCE RHD

2.10e-052160210329015
Pubmed

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2.

TRPM2 NFE2L2

2.10e-052160231575956
Pubmed

RHCE*ceMO is frequently in cis to RHD*DAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance.

RHCE RHD

2.10e-052160223772606
Pubmed

CYP3A gene expression in human gut epithelium.

CYP3A7 CYP3A5

2.10e-05216027894497
Pubmed

Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.

RHCE RHD

2.10e-05216023135863
Pubmed

Sequences and evolution of mammalian RH gene transcripts and proteins.

RHCE RHD

2.10e-05216029811965
Pubmed

CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.

CYP3A7 CYP3A5

2.10e-052160228500872
Pubmed

Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.

RHCE RHD

2.10e-052160212393640
Pubmed

Molecular genetic basis of the human Rhesus blood group system.

RHCE RHD

2.10e-05216028220426
Pubmed

Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC.

SPARC ANPEP

2.10e-052160219236378
Pubmed

Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system.

RHCE RHD

2.10e-05216027916743
Pubmed

RHD*DOL1 and RHD*DOL2 encode a partial D antigen and are in cis with the rare RHCE*ceBI allele in people of African descent.

RHCE RHD

2.10e-052160222690701
Pubmed

No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes.

RHCE RHD

2.10e-052160226872772
Pubmed

RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa.

RHCE RHD

2.10e-052160222804620
Pubmed

Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer.

PAX2 PAX5

2.10e-052160226823795
Pubmed

Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells.

RHCE RHD

2.10e-05216027789951
Pubmed

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

CLTCL1 CLTC

2.10e-05216028733129
Pubmed

SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo.

SPARC DMD

2.10e-052160227908613
Pubmed

E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop.

RHCE RHD

2.10e-052160211724987
Pubmed

The Rh blood group system: a review.

RHCE RHD

2.10e-052160210627438
Pubmed

Polymorphisms in the promoter regions of RHD and RHCE genes in the Chinese Han population.

RHCE RHD

2.10e-052160237823181
Pubmed

Sequence diversity of the Rh blood group system in Basques.

RHCE RHD

2.10e-052160230089826
Pubmed

Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.

SEC31A ALK

2.10e-052160216161041
Pubmed

Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.

RHCE RHD

2.10e-052160229193104
Pubmed

Identification of two promoters for human D-amino acid oxidase gene: implication for the differential promoter regulation mediated by PAX5/PAX2.

PAX2 PAX5

2.10e-052160225500505
Pubmed

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

CLTCL1 CLTC

2.10e-052160229097553
Pubmed

Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable.

ACTN2 DMD

2.10e-052160212140183
Pubmed

Lack of strong effect modification by NFE2L2/CYP3A5/ABO of the risk of venous thrombosis associated with oral hormone therapy.

CYP3A5 NFE2L2

2.10e-052160223734777
Pubmed

RHCE variants inherited with altered RHD alleles in Brazilian blood donors.

RHCE RHD

2.10e-052160227111588
Pubmed

Alteration of RH gene structure and expression in human dCCee and DCW-red blood cells: phenotypic homozygosity versus genotypic heterozygosity.

RHCE RHD

2.10e-05216028822955
Pubmed

Genetic recombination at the human RH locus: a family study of the red-cell Evans phenotype reveals a transfer of exons 2-6 from the RHD to the RHCE gene.

RHCE RHD

2.10e-05216028808597
Pubmed

Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese.

RHCE RHD

2.10e-052160212201845
Pubmed

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

CLTCL1 CLTC

2.10e-052160220065094
Pubmed

Variant RH alleles and Rh immunisation in patients with sickle cell disease.

RHCE RHD

2.10e-052160224960646
Pubmed

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.

PAX2 PAX5

2.10e-052160210662641
Pubmed

The proapoptotic gene interferon regulatory factor-1 mediates the antiproliferative outcome of paired box 2 gene and tamoxifen.

IRF1 PAX2

2.10e-052160232843722
Pubmed

Comprehensive phenotypic and molecular investigation of RhD and RhCE variants in Moroccan blood donors.

RHCE RHD

2.10e-052160230418133
Pubmed

A convenient qualitative and quantitative method to investigate RHD-RHCE hybrid genes.

RHCE RHD

2.10e-052160223550903
Pubmed

Molecular cloning and primary structure of the human blood group RhD polypeptide.

RHCE RHD

2.10e-05216021438298
Pubmed

The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin.

TRPM2 GHSR

2.10e-052160226370322
Pubmed

Molecular background of D(C)(e) haplotypes within the white population.

RHCE RHD

2.10e-052160212084172
Pubmed

The analysis of nucleotide substitutions, gaps, and recombination events between RHD and RHCE genes through complete sequencing.

RHCE RHD

2.10e-052160210924335
Pubmed

A two-locus gene conversion model with selection and its application to the human RHCE and RHD genes.

RHCE RHD

2.10e-052160212857961
Pubmed

Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD.

RHCE RHD

2.10e-052160220233350
Pubmed

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.

DPP9 NFE2L2

2.10e-052160237713596
Pubmed

A recombination hot spot in the Rh genes revealed by analysis of unrelated donors with the rare D-- phenotype.

RHCE RHD

2.10e-05216028900235
Pubmed

RHD*weak partial 4.0 is associated with an altered RHCE*ce(48C, 105T, 733G, 744C, 1025T) allele in the Tunisian population.

RHCE RHD

2.10e-052160223742316
Pubmed

A comprehensive survey of both RHD and RHCE allele frequencies in sub-Saharan Africa.

RHCE RHD

2.10e-052160224033223
Pubmed

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue.

CYP3A7 CYP3A5

2.10e-05216028877031
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

CYP3A5 CYP17A1 TNFRSF10A RRM1 FANCA TLR10 GHSR IGFBP1 ZNF624

3.88e-05351160920453000
Pubmed

Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection.

DNAH1 RSPH3

6.29e-053160232124190
Pubmed

NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR.

ATG7 NFE2L2

6.29e-053160235204252
Pubmed

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

CLTCL1 CLTC

6.29e-053160219509056
Pubmed

Differential regulation of steroidogenic enzyme genes by TRα signaling in testicular Leydig cells.

CYP17A1 NFE2L2

6.29e-053160224725081
Pubmed

A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism.

LRRK2 NFE2L2

6.29e-053160237674036
Pubmed

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.

CYP3A7 CYP3A5

6.29e-053160219801957
Pubmed

Evolutionary history of the Rh blood group-related genes in vertebrates.

RHCE RHD

6.29e-053160210970100
Pubmed

Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.

CYP3A7 CYP3A5

6.29e-053160220621111
Pubmed

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.

VPS52 NFE2L2

6.29e-053160227889639
Pubmed

Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene.

RHCE RHD

6.29e-05316029705835
Pubmed

CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility.

CYP3A7 CYP3A5

6.29e-053160220345875
Pubmed

Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation.

ATG7 NFE2L2

6.29e-053160235203398
Pubmed

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

NCF4 RNF145

6.29e-053160226194095
Pubmed

The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways.

RHCE RHD

6.29e-05316029929383
Pubmed

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.

CYP3A7 CYP3A5

6.29e-05316027811260
Pubmed

Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.

LRRK2 NFE2L2

6.29e-053160228028237
Pubmed

Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.

RHCE RHD

6.29e-05316023146980
Pubmed

Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.

CYP3A7 CYP3A5

6.29e-053160220118548
Pubmed

Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.

FAAH NFE2L2

6.29e-053160223347118
Pubmed

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.

LRRK2 CLTC

6.29e-053160229735704
Pubmed

Generation and characterisation of Rhd and Rhag null mice.

RHCE RHD

6.29e-053160219807729
Pubmed

Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

CLTCL1 CLTC

6.29e-053160222891263
Pubmed

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway.

NFE2L2 DMD

6.29e-053160228472288
Pubmed

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.

CYP3A7 CYP3A5

6.29e-053160223143891
Pubmed

Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.

CYP3A7 CYP3A5

6.29e-053160233866277
GeneFamilyGuanylate cyclase receptors

NPR2 GUCY2F

7.83e-0471122343
GeneFamilyCytochrome P450 family 3

CYP3A7 CYP3A5

1.04e-03811221002
GeneFamilyPaired boxes

PAX2 PAX5

1.33e-0391122675
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

COG2 GBF1 CYP3A5 POLD1 TBC1D31 VNN2 LRRN2 DEPDC1B

6.63e-0720016086e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellSigmoid-T_cell-cycling_gd_T|Sigmoid / Region, Cell class and subclass

COG2 GBF1 CYP3A5 POLD1 TBC1D31 VNN2 LRRN2 DEPDC1B

6.63e-0720016089769185abae084ffac36420c749625e679b70ca8
ToppCellmoderate-Epithelial-unknown_epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CYP3A5 ACTN2 GPRC5A RHCE CCNE2 FHIP1A NLRP8

6.91e-071381607afefa8233c67aa744e939156bc538449bf6bd05b
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FAM227B GRPR FANCA IGFBP1 PAX2

2.29e-06591605439a9d56eeecccd70a4defb430e228329655cb80
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FAM227B GRPR FANCA IGFBP1 PAX2

2.29e-0659160550432c7b52fd197e8856ba0296c34cf66a2faaf5
ToppCellPBMC-Control-cDC_12|Control / Compartment, Disease Groups and Clusters

POLD1 RRM1 ADCY3 FANCA PRMT6 CCNE2 SLC29A4

4.37e-0618216074774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPATA3 NPHP1 CNTN4 ADCY3 FBXL6 ESYT2 CDADC1

7.35e-061971607dfeb4a0eb4dfba90f4a3e6ba31e0ab0e4aba5849
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A FAM227B USP9Y PAX5 PLCH1 NLRP8

1.32e-0514316067a7a9829ba63468c9745904d9e993590051207ab
DiseaseAnemia, Hemolytic, Congenital

RHCE RHD

2.67e-0521532C0002881
DiseaseSecondary Biliary Cholangitis

STAT4 SLC51B IGFBP1 NFE2L2

6.67e-05421534C0238065
DiseaseBiliary cirrhosis

STAT4 SLC51B IGFBP1 NFE2L2

6.67e-05421534C0023892
DiseaseBiliary Cirrhosis, Primary, 1

STAT4 SLC51B IGFBP1 NFE2L2

6.67e-05421534C4551595
DiseaseRh Deficiency Syndrome

RHCE RHD

7.99e-0531532C0272052
DiseaseRh-Null, Regulator Type

RHCE RHD

7.99e-0531532C1849387
DiseasePrimary biliary cirrhosis

STAT4 SLC51B IGFBP1 NFE2L2

1.04e-04471534C0008312
Diseasenephrotic syndrome type 20 (implicated_via_orthology)

TBC1D9B TBC1D8B

1.59e-0441532DOID:0070357 (implicated_via_orthology)
Diseasetacrolimus measurement

CYP3A7 CYP3A5

1.59e-0441532EFO_0008458
DiseaseNecrosis

SPARC ATG7 NFE2L2 DMD

1.93e-04551534C0027540
DiseaseOvarian Serous Adenocarcinoma

LRRK2 TRRAP ALK

2.24e-04231533C1335177
Diseaseprocollagen C-endopeptidase enhancer 2 measurement

PAQR9 ZNF18

3.95e-0461532EFO_0801921
DiseaseInflammatory Myofibroblastic Tumor

CLTC ALK

3.95e-0461532C0334121
Diseaseperoxisomal biogenesis disorder (implicated_via_orthology)

PEX1 PEX5L

7.33e-0481532DOID:0080377 (implicated_via_orthology)
DiseaseCutaneous Melanoma

TRRAP ALK CUX1

1.26e-03411533C0151779
Diseasenevus count, cutaneous melanoma

GPRC5A STN1 FANCA FHIP2B

1.31e-03911534EFO_0000389, EFO_0004632
Diseasepolybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement

PEX5L LOXHD1

1.42e-03111532EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Diseaseendometrial carcinoma, endometriosis

TLR10 SKAP1

1.42e-03111532EFO_0001065, EFO_1001512
DiseaseProstatic Neoplasms

DDR1 RNF31 CYP3A5 ARHGEF5 CYP17A1 TNFRSF10A GRPR VPS52 FAF2 NFE2L2

1.46e-0361615310C0033578
DiseaseMalignant neoplasm of prostate

DDR1 RNF31 CYP3A5 ARHGEF5 CYP17A1 TNFRSF10A GRPR VPS52 FAF2 NFE2L2

1.46e-0361615310C0376358
Diseasechronic musculoskeletal pain

WWP2 FAF2

1.70e-03121532EFO_0022195
Diseaseovarian serous carcinoma

STN1 GK2 SKAP1

1.76e-03461533EFO_1001516
Diseasewaist circumference

CYP17A1 WWP2 DCP2 HECTD4 TEX15 ADCY3 PRMT6 DMD

1.85e-034291538EFO_0004342
Diseaseliver cirrhosis (implicated_via_orthology)

FOCAD NFE2L2

2.01e-03131532DOID:5082 (implicated_via_orthology)
DiseaseCarcinogenesis

NFE2L2 CUX1

2.01e-03131532C0596263
DiseaseLeukemia, Myelocytic, Acute

SPARC IRF1 FANCA IFI30 CUX1

2.13e-031731535C0023467
Diseaseskin melanoma (is_implicated_in)

DDR1 FANCA

2.33e-03141532DOID:8923 (is_implicated_in)
DiseaseHamman-Rich syndrome

STN1 DPP9

2.33e-03141532C0085786
DiseaseHypogonadotropic hypogonadism

POLD1 CYP17A1

2.68e-03151532C0271623
DiseasePeroxisome biogenesis disorders

PEX1 PEX5L

2.68e-03151532C1832200
DiseasePrimary hypogonadism

POLD1 CYP17A1

2.68e-03151532C0948896
DiseaseHypogonadism, Isolated Hypogonadotropic

POLD1 CYP17A1

2.68e-03151532C3489396
DiseaseDiffuse Large B-Cell Lymphoma

SEC31A CLTC ALK

2.94e-03551533C0079744
DiseaseHypogonadism

POLD1 CYP17A1

3.06e-03161532C0020619
Diseasecathepsin L1 measurement

LRRK2 IFI30

3.06e-03161532EFO_0010619
DiseaseColorectal Carcinoma

CNTN4 SLC66A2 SPARC POLD1 CORO1B PEX5L ZNF624 DMD CUX1 NLRP8

3.73e-0370215310C0009402
Diseaseessential hypertension (is_implicated_in)

NPR2 CYP3A5

3.87e-03181532DOID:10825 (is_implicated_in)
DiseaseAdrenocortical carcinoma

SPARC RRM1

3.87e-03181532C0206686
DiseaseMalignant neoplasm of breast

RCE1 XIRP1 TBC1D9B CYP17A1 ELP1 FAAH STAT4 RHD GUCY2F DMD ALK CUX1 NLRP8

4.02e-03107415313C0006142
Diseaseplatelet crit

KIF26A PIEZO1 LRRK2 ELOVL1 IRF1 RHCE STN1 RHD SKAP1 LRRN2 FHIP1A CUX1

4.12e-0395215312EFO_0007985
Diseasemetabolonic lactone sulfate measurement

CYP3A7 CYP3A5

4.31e-03191532EFO_0800659
DiseaseUsual Interstitial Pneumonia

STN1 DPP9

4.31e-03191532C4721509
DiseaseHamman-Rich Disease

STN1 DPP9

4.31e-03191532C4721508
Diseaseanorectal malformation

TRPM2 NLRP8

4.31e-03191532MONDO_0019938
DiseaseSarcomatoid Renal Cell Carcinoma

LRRK2 SPTBN4 RNF139 ALK

4.51e-031281534C1266043
DiseaseChromophobe Renal Cell Carcinoma

LRRK2 SPTBN4 RNF139 ALK

4.51e-031281534C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

LRRK2 SPTBN4 RNF139 ALK

4.51e-031281534C1266044
DiseasePapillary Renal Cell Carcinoma

LRRK2 SPTBN4 RNF139 ALK

4.51e-031281534C1306837
DiseaseRenal Cell Carcinoma

LRRK2 SPTBN4 RNF139 ALK

4.51e-031281534C0007134
DiseaseFamilial Idiopathic Pulmonary Fibrosis

STN1 DPP9

4.77e-03201532C4721952

Protein segments in the cluster

PeptideGeneStartEntry
NWEILTPIRAELMRT

PRAMEF33

426

A0A0G2JMD5
WENVPRIFEALLIME

FAM227B

71

Q96M60
LRLEWLTLMPNASNL

ESYT2

501

A0FGR8
MDPSVTLWQFLLQLL

ELK1

1

P19419
LRERLIIWAAMDSIP

ELL3

106

Q9HB65
LGMIWTIILRFAIQD

ACTN2

131

P35609
MDLIPNLAVETWLLL

CYP3A5

1

P20815
REPFIRMQLWLNGEL

CUX1

996

P39880
LRWISALAMPREELD

ARHGEF5

1491

Q12774
VTLWEVLMLCRAQPF

DDR1

831

Q08345
WRMRVDIEVDPLQLL

FAM78B

191

Q5VT40
LDEPTNMLDVRAILW

ABCF3

351

Q9NUQ8
WILIAMFQLAVDLPA

AJAP1

26

Q9UKB5
DLEPQMRSILLDWLL

CCNE2

136

O96020
MRLPWELLVLQSFIL

CNTN4

1

Q8IWV2
RMSERQLALWDPENL

CORO1B

241

Q9BR76
VAPMVDQSELAWRLL

DUS1L

21

Q6P1R4
FLQDEWDLLQRMILL

DUS1L

121

Q6P1R4
LWNETVELFRAKMPL

DEPDC1B

16

Q8WUY9
QWSLSPDLRQTLLML

CCDC142

621

Q17RM4
LMIDLEALLPTRRWF

AQR

256

O60306
LIEERQYMPWEAALS

ANPEP

686

P15144
LVLLMERCWAQDPAE

NPR2

761

P20594
VNLFTLLSLWMELFP

CDADC1

36

Q9BWV3
LLSLWMELFPAEAQR

CDADC1

41

Q9BWV3
FMAIPFIRPLRDWLS

DCP2

226

Q8IU60
LLASLEWLMPNRFSQ

FBXL6

181

Q8N531
IEAALFLDWMRLEPQ

DMD

3276

P11532
WMTERVDFTALLPLE

ATF5

66

Q9Y2D1
WAPVFLDREQSISLM

NUBP2

76

Q9Y5Y2
LMLPDFDRRWDDTIL

GPRC5A

231

Q8NFJ5
MDATWLDSLLTPVRL

IRF1

301

P10914
DLLEMIVTWIFEDPR

INTS15

201

Q96N11
NPTMFAWEIRDRLLA

PAX5

106

Q02548
MLLPLAWRIVNDTYR

CCNC

171

P24863
ILLAQSWMPRETVIF

MEIOB

216

Q8N635
DLLDPARWRMLIQQF

MAEA

256

Q7L5Y9
SQASLPMLEERVLDW

NFRKB

391

Q6P4R8
TWDIDRQFMLGPAIL

MGAM2

1601

Q2M2H8
LLETFWERMNLKVPI

INTS11

251

Q5TA45
PEATLLIMIRFTSWQ

NLRP8

326

Q86W28
LVDPQISLWVLMAIL

FNDC9

106

Q8TBE3
LLRAIDSRWFEMLPN

LRRN2

176

O75325
LEELPRTVNTMALLW

DOP1B

1621

Q9Y3R5
RPEWFLERILLKNMN

LOXHD1

1626

Q8IVV2
DMRWLRNQVIAPLTE

RCE1

161

Q9Y256
DIPWRLKQMLDILVY

FHIP2B

51

Q86V87
MSEVPVARVWLVLLL

IGFBP1

1

P08833
WAALRIALSLMDQPE

PEX5L

591

Q8IYB4
LPSQQDMDLIDILWR

NFE2L2

11

Q16236
QALMLDFPDWREDVL

FRYL

601

O94915
LHYLLPWMNNIELVD

FRYL

1306

O94915
NVMWLQPLLAAIRED

GALNT11

251

Q8NCW6
LLSLPVWVLMDEDVR

NCF4

116

Q15080
PMGFWSRLINRLLEI

LRRK2

1701

Q5S007
RLMLEPGRWLEQFEV

KIF26A

1811

Q9ULI4
DTLQLMERSLPEIWT

ELP1

1261

O95163
LLHMPFLEVIDVDWN

LRRC10

186

Q5BKY1
PEDMLWFHRALTLLI

HECTD4

2926

Q9Y4D8
MDERFNKWLLTPVLT

HS6ST3

1

Q8IZP7
ATAVMSPEELLRAWI

IL20RB

296

Q6UXL0
NPTMFAWEIRDRLLA

PAX2

106

Q02962
PIMLESWLFDLRGEN

PAQR9

256

Q6ZVX9
PLLSTIDDFWQMVLE

PTPN20

231

Q4JDL3
SRIHQDETWILFLPM

IL1RL2

71

Q9HB29
IVWAPNLLRSMELES

ARHGAP33

466

O14559
LSSWVMDLLQRLDFL

DNAH1

4086

Q9P2D7
WLLLPSLVQFMNSLE

FHIP1A

276

Q05DH4
VFLLMDTRESRWLPA

ATG7

471

O95352
VWSLEPQALSVLRME

GK2

471

Q14410
PWFERISMLVILLNC

CACNA1G

81

O43497
RELFPTWLLVMEILN

IFI30

81

P13284
LIFLCMPLDLVRLWQ

GHSR

91

Q92847
ILTDEQFDRLWNEMP

EFCAB6

1211

Q5THR3
AMFLDRPQQWLQLVL

DPP9

366

Q86TI2
PEAQQLLEDWVARLM

FANCA

401

O15360
ILARQELFLIMAWLL

CYP17A1

446

P05093
ELFLIMAWLLQRFDL

CYP17A1

451

P05093
MAWLLQRFDLEVPDD

CYP17A1

456

P05093
SMEELLWTAPELLRA

GUCY2F

706

P51841
AAFIWIISMLLAIPE

GRPR

161

P30550
MFALLLADRSWLLEQ

C1orf112

696

Q9NSG2
MDPKARRFLWNLILD

ABCA2

2216

Q9BZC7
TALVEILIDPWLMTN

ADCY3

646

O60266
LFIAPISDQMLEWRL

PRMT6

191

Q96LA8
SPEALRMVRVAWLFL

ELOVL1

101

Q9BW60
AMLLSPWVDFFELQL

BPESC1

101

Q9GZL8
LLDWDMRNELFLPCT

FOXR2

21

Q6PJQ5
PVIQRLLEAFTERWM

GBF1

796

Q92538
LLLWLPDTTREIVMT

IGKV3-7

11

A0A075B6H7
MAGPELLLDSNIRLW

EMC3

1

Q9P0I2
QWRALDLDVVLTPML

FAAH

461

O00519
SDEMFLPLLVHRLWR

COG2

431

Q14746
MDLIPNLAVETWLLL

CYP3A7

1

P24462
DWSREIRELPLLNAM

PIWIL3

491

Q7Z3Z3
QKMSEIFPLTEELWL

SART3

136

Q15020
DLLQAWSTFIRIMDP

POLD1

376

P28340
AVWMQPSVVLLDDLD

PEX1

651

O43933
VNWAALLSPLMRLNF

FOCAD

1406

Q5VW36
LLEQPDVMDALRSSW

NPHP1

616

O15259
LKRFTLQFLPELMWV

FAM126B

71

Q8IXS8
VPQELLEEMLWFFRV

SLC51B

16

Q86UW2
LQLLMEDTWKRIRFP

RNF139

221

Q8WU17
RLLAPLMPFLAEELW

VARS2

851

Q5ST30
DDPVWNIQIARMLEL

STN1

156

Q9H668
PALEWAVSNREMLIA

RMND5A

171

Q9H871
MFIWRSLLQLPENHT

TBC1D31

431

Q96DN5
MAPGLDLISVEWRLQ

TAPBPL

216

Q9BX59
VLPMDTNFWVLLRDG

TLR10

196

Q9BXR5
LTPAELIERLEQAWM

GINS4

21

Q9BRT9
PLLRLWDEVMQAVAR

TCAF1

686

Q9Y4C2
SKWFDALPNLEILMI

LRRN3

181

Q9H3W5
LSAMDADSPLLWIRI

TAF2

616

Q6P1X5
SEIPIMSCLEFLWER

MRM1

236

Q6IN84
MSCLEFLWERPTLLV

MRM1

241

Q6IN84
PEVISLINTRMLFWA

FAF2

196

Q96CS3
FGLVQPLVTMEQLLW

NEU1

51

Q99519
AEELFLWVPRKLLMT

SETD3

116

Q86TU7
LEPWERSMFNTILLT

SPTSSB

26

Q8NFR3
SIQELEIRNMSWPRL

PRAMEF1

206

O95521
SRIFDVLLPRDWQMA

SPATA3

131

Q8NHX4
EAFWLLVALCERMLP

TBC1D9B

611

Q66K14
MVLPLLDVSDRFWLQ

ALK

596

Q9UM73
TPDWIFLLRNVMRIS

CLTC

511

Q00610
LLRPDMVLELAWRHN

CLTCL1

1576

P53675
FLRWMTPDSIIDVAI

PIGA

441

P37287
LQWLRSELPYVLEMV

RNF31

521

Q96EP0
MGPALERIDYLLILW

TRPC1

416

P48995
TAWMNVLPLLTAIEF

VNN2

236

O95498
LWPRFELILEMNVQS

VPS52

476

Q8N1B4
IERDIEIGFLPWLMN

RSPH3

426

Q86UC2
IDFTLEEWRLMDPTQ

ZNF624

61

Q9P2J8
REWFFLLSHEVLNPM

WWP2

561

O00308
LLAMTFWPAVREDNR

YIPF1

241

Q9Y548
EPWMILREETQFTDL

ZNF573

86

Q86YE8
LFMLALGVQWAILLD

RHD

81

Q02161
LFMLALGVQWAILLD

RHCE

81

P18577
AFWLLVAVCERMLPD

TBC1D8B

591

Q0IIM8
ALWIPDLFMKRVETN

RRM1

331

P23921
LETPVIDNIRWCLDM

TMEM94

246

Q12767
LDSELTEFPLRMRDW

SPARC

156

P09486
TEFPLRMRDWLKNVL

SPARC

161

P09486
FPMEIRHLLAQWIEN

STAT4

26

Q14765
TFTMDPIRDLLIWAI

TRPM2

616

O94759
ALDRWAQFFIHPLMI

NRDC

286

O43847
NWEILTPIRAELMRT

PRAMEF10

426

O60809
DELAWVQERLPLAMQ

SPTBN4

1526

Q9H254
TTWDLREMREPFLNL

SMCO2

321

A6NFE2
QDWFPLLELLAMALN

USP9Y

166

O00507
VWLARNLSDIDLMAP

TOMM6

56

Q96B49
PFDSWDQLMRQLDLT

TNFRSF10A

376

O00220
MPEIALVRFLVWDHD

PLCH1

801

Q4KWH8
DEMVTLWRLAVLDPA

ZSWIM8

421

A7E2V4
WDRMPELVRQLQTLS

TTC7A

26

Q9ULT0
WLPILIMAVFNLSDF

SLC29A4

386

Q7RTT9
LEQFLTILPGEIQMW

ZNF18

86

P17022
IHLWMFFILPAVTER

PIEZO1

2041

Q92508
MLWFDLSLLPELVQC

TEX15

2091

Q9BXT5
MAADLNLEWISLPRS

PLEKHA5

1

Q9HAU0
DRLPVIQMWDLRFAS

SEC31A

236

O94979
RVPSIMLLDVLYRWD

RNF145

16

Q96MT1
MAWQVSLPELEDRLQ

TRIM50

1

Q86XT4
MLVDRHPSWELFQEI

WDR87

1276

Q6ZQQ6
ELMQALWRTLRNPAD

TRRAP

871

Q9Y4A5
FLMERLPLTWVLQNQ

TRRAP

1166

Q9Y4A5
RWLFETQPLEMIHQR

XIRP1

551

Q702N8
RRFESPLLWQSAIMI

SLC66A2

71

Q8N2U9
MQAAALPEEIRWLLE

SKAP1

1

Q86WV1
HELIESMPLLEWFAN

ETF1

366

P62495
QWLRDLPNPLMTFEL

MYO9A

2136

B2RTY4