Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloexopeptidase activity

CPA3 ERAP1 LNPEP ENPEP

3.54e-0670304GO:0008235
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

ERAP1 LNPEP ENPEP

7.77e-0626303GO:0070006
GeneOntologyMolecularFunctionexopeptidase activity

CPA3 ERAP1 LNPEP ENPEP

2.14e-05110304GO:0008238
GeneOntologyMolecularFunctionaminopeptidase activity

ERAP1 LNPEP ENPEP

3.63e-0543303GO:0004177
GeneOntologyMolecularFunctionpeptidase activity

CTRC CPA3 ERAP1 LNPEP ENPEP USP32 USP24

4.13e-05654307GO:0008233
GeneOntologyMolecularFunctionmetallopeptidase activity

CPA3 ERAP1 LNPEP ENPEP

2.18e-04200304GO:0008237
GeneOntologyMolecularFunctionzinc ion binding

CPA3 RNF7 TRIM49B ERAP1 CREBBP LNPEP ENPEP

2.84e-04891307GO:0008270
GeneOntologyMolecularFunctionDNA replication origin binding

ORC2 CDC45

3.29e-0418302GO:0003688
GeneOntologyMolecularFunctionpeptide binding

ERAP1 LNPEP ENPEP CHRNA7

1.25e-03318304GO:0042277
GeneOntologyMolecularFunctiontransition metal ion binding

CPA3 RNF7 TRIM49B ERAP1 CREBBP LNPEP ENPEP

1.58e-031189307GO:0046914
GeneOntologyMolecularFunctionhistone acetyltransferase activity

MED24 CREBBP

2.66e-0351302GO:0004402
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

MED24 CREBBP

3.08e-0355302GO:0061733
GeneOntologyBiologicalProcesspeptide catabolic process

ERAP1 LNPEP ENPEP

4.82e-0623303GO:0043171
GeneOntologyBiologicalProcessregulation of blood pressure

CPA3 ERAP1 LNPEP ENPEP CHRNA7

2.16e-05237305GO:0008217
GeneOntologyBiologicalProcesscirculatory system process

CPA3 ABCC4 FERMT2 ERAP1 LNPEP ENPEP CHRNA7

6.93e-05733307GO:0003013
GeneOntologyBiologicalProcessangiotensin maturation

CPA3 ENPEP

7.32e-059302GO:0002003
GeneOntologyBiologicalProcessregulation of angiotensin levels in blood

CPA3 ENPEP

1.12e-0411302GO:0002002
GeneOntologyBiologicalProcessregulation of synaptic transmission, dopaminergic

CNTNAP4 CHRNA7

1.58e-0413302GO:0032225
GeneOntologyBiologicalProcesspeptide metabolic process

ERAP1 LNPEP ENPEP

2.44e-0484303GO:0006518
GeneOntologyBiologicalProcessblood circulation

CPA3 FERMT2 ERAP1 LNPEP ENPEP CHRNA7

2.93e-04648306GO:0008015
MousePhenofailure of neuromuscular synapse presynaptic differentiation

LRP4 CHRNA7

4.59e-056252MP:0001054
MousePhenosmall lung

LRP4 PTGES3 CREBBP SYNE1

4.81e-05115254MP:0003641
MousePhenosupernumerary teeth

LRP4 CREBBP

2.37e-0413252MP:0004033
MousePhenodecreased prostaglandin level

ABCC4 PTGES3

2.37e-0413252MP:0009815
MousePhenoabnormal lung size

LRP4 PTGES3 CREBBP SYNE1

2.39e-04174254MP:0004881
DomainERAP1-like_C_dom

ERAP1 LNPEP ENPEP

2.31e-078313IPR024571
DomainERAP1_C

ERAP1 LNPEP ENPEP

2.31e-078313PF11838
DomainPeptidase_M1

ERAP1 LNPEP ENPEP

9.02e-0712313IPR001930
DomainPeptidase_M1

ERAP1 LNPEP ENPEP

1.17e-0613313PF01433
DomainPeptidase_M1_N

ERAP1 LNPEP ENPEP

1.17e-0613313IPR014782
DomainZINC_PROTEASE

ERAP1 LNPEP ENPEP

5.66e-0498313PS00142
DomainEGF

SELL CNTNAP4 LRP4

1.17e-03126313PF00008
DomainUSP_CS

USP32 USP24

5.35e-0366312IPR018200
DomainUSP_1

USP32 USP24

6.00e-0370312PS00972
DomainUCH

USP32 USP24

6.17e-0371312PF00443
DomainUSP_2

USP32 USP24

6.17e-0371312PS00973
DomainUSP_3

USP32 USP24

6.34e-0372312PS50235
DomainUSP_dom

USP32 USP24

6.34e-0372312IPR028889
DomainPeptidase_C19_UCH

USP32 USP24

6.34e-0372312IPR001394
DomainEGF_3

SELL CNTNAP4 LRP4

6.82e-03235313PS50026
DomainEGF

SELL CNTNAP4 LRP4

6.82e-03235313SM00181
DomainEGF-like_dom

SELL CNTNAP4 LRP4

7.99e-03249313IPR000742
DomainEGF_1

SELL CNTNAP4 LRP4

8.53e-03255313PS00022
DomainEGF-like_CS

SELL CNTNAP4 LRP4

9.08e-03261313IPR013032
DomainEGF_2

SELL CNTNAP4 LRP4

9.47e-03265313PS01186
PathwayKEGG_RENIN_ANGIOTENSIN_SYSTEM

CPA3 LNPEP ENPEP

3.72e-0617263M17636
Pubmed

Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.

ERAP1 LNPEP ENPEP

2.56e-09431317999179
Pubmed

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.

ERAP1 LNPEP

7.69e-07231220592285
Pubmed

The human homolog of Saccharomyces cerevisiae CDC45.

ORC2 CDC45

7.69e-0723129660782
Pubmed

Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.

ERAP1 LNPEP

2.31e-06331211857741
Pubmed

Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.

ERAP1 LNPEP

2.31e-06331215691326
Pubmed

Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.

ERAP1 LNPEP

2.31e-06331236716917
Pubmed

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

ERAP1 LNPEP

2.31e-06331221314638
Pubmed

The oxytocinase subfamily of M1 aminopeptidases.

ERAP1 LNPEP

2.31e-06331216054015
Pubmed

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.

ERAP1 LNPEP

4.61e-06431224957906
Pubmed

Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa.

LNPEP ENPEP

4.61e-06431226311161
Pubmed

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

USP32 USP24

2.76e-05931237149635
Pubmed

Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.

ATP1B4 SYNE1

4.21e-051131226939788
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

MED24 CREBBP

5.05e-051231212189208
Pubmed

Interactions of MCP1 with components of the replication machinery in mammalian cells.

ORC2 CDC45

6.95e-051431221383955
Pubmed

Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.

ORC2 CREBBP

1.04e-041731214519686
Pubmed

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.

ORC2 CDC45

1.30e-041931215226314
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED24 CREBBP

1.30e-041931216799563
Pubmed

Constraint and divergence of global gene expression in the mammalian embryo.

MED24 ABHD12

1.30e-041931225871848
Pubmed

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.

MED24 CREBBP

1.30e-041931216204234
Pubmed

Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.

ORC2 CDC45

1.45e-042031212614612
Pubmed

The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.

ERAP1 LNPEP

1.60e-042131219578876
Pubmed

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.

ORC2 CDC45

1.76e-042231215707391
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED24 CREBBP

1.92e-042331210235267
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

OSBPL9 ERAP1 ABHD12 LNPEP

1.93e-0432531436168628
Pubmed

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.

OSBPL9 FERMT2 LNPEP SYNE1

2.27e-0433931437232246
Pubmed

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

ORC2 CREBBP

2.66e-042731217525332
Pubmed

Self-assembling protein microarrays.

ORC2 CDC45

3.29e-043031215232106
Pubmed

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

ORC2 CDC45

4.24e-043431212791985
Pubmed

Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.

OSBPL9 MED24 CREBBP

4.74e-0417131336629882
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

OSBPL9 LRP4 ABCC4 ERAP1 ABHD12 LNPEP

5.88e-04120131635696571
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

OSBPL9 CREBBP SYNE1

7.16e-0419731320811636
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

LRP4 PTGES3 ABHD12 CREBBP SYNE1 USP32

8.37e-04128531635914814
Cytoband5q15

KIAA0825 ERAP1 LNPEP

2.45e-06403035q15
CytobandEnsembl 112 genes in cytogenetic band chr5q15

KIAA0825 ERAP1 LNPEP

7.99e-0659303chr5q15
Cytoband1p32.3

OSBPL9 USP24

7.38e-04613021p32.3
CytobandEnsembl 112 genes in cytogenetic band chr11p11

LRP4 TRIM49B

4.51e-03153302chr11p11
CytobandEnsembl 112 genes in cytogenetic band chr1p32

OSBPL9 USP24

4.63e-03155302chr1p32
GeneFamilyAminopeptidases|CD molecules

ERAP1 LNPEP ENPEP

1.38e-0617243104
GeneFamilyUbiquitin specific peptidases

USP32 USP24

2.49e-0356242366
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

OSBPL9 FERMT2

3.02e-02206242682
CoexpressionGSE19374_UNINF_VS_LISTERIA_INFECTED_MACROPHAGE_DN

MED24 ATP1B4 FERMT2 LNPEP TIGD6

2.86e-06198305M7265
CoexpressionAtlasgamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3

SELL PITPNM2 MED24 CPA3 CDC45

1.19e-04362295GSM605784_500
CoexpressionAtlaskidney_adult_RenCorpuscGlomer_k-means-cluster#3_top-relative-expression-ranked_1000

OSBPL9 FERMT2 ERAP1 LNPEP

1.29e-04192294gudmap_kidney_adult_RenCorpuscGlomer_k3_1000
CoexpressionAtlaskidney_adult_RenMedVasc_Tie2_k-means-cluster#3_top-relative-expression-ranked_1000

FERMT2 LNPEP ENPEP

1.75e-0480293gudmap_kidney_adult_RenMedVasc_Tie2_k3_1000
CoexpressionAtlasB cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3

DRC7 RNF7 WDFY4 ENPEP CDC45

1.89e-04400295GSM538358_500
CoexpressionAtlasalpha beta T cells, preT.DN2A.Th, Lin-/lo CD25hi CD44+ cKithi, Thymus, avg-2

SELL DRC7 CPA3 WDFY4 CDC45

2.10e-04409295GSM791139_500
CoexpressionAtlasalpha beta T cells, preT.ETP.Th, Lin-/lo CD25- CD44+ cKit+, Thymus, avg-3

SELL DRC7 CPA3 WDFY4 CDC45

2.24e-04415295GSM854335_500
CoexpressionAtlasalpha beta T cells, preT.ETP-2A.Th, Lin-/lo CD25int CD44+ cKit+, Thymus, avg-2

SELL DRC7 MED24 CPA3 WDFY4

2.53e-04426295GSM791152_500
CoexpressionAtlaskidney_adult_Podocyte_MafB_top-relative-expression-ranked_500

OSBPL9 FERMT2 ERAP1 LNPEP ENPEP

3.10e-04445295gudmap_kidney_adult_Podocyte_MafB_500
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP4 CPA3 FERMT2 CHRNA7

3.83e-06159304ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP4 CPA3 FERMT2 CHRNA7

3.83e-061593047b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

PITPNM2 CPA3 ABCC4 FERMT2

4.44e-0616530493d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

PITPNM2 CPA3 ABCC4 FERMT2

4.44e-061653045fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCellHealthy_Control-Myeloid-Mast-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CPA3 ABCC4 FERMT2 CHRNA7

5.60e-06175304eadbbcdf2aef4cee268bc70a7a2c4175d898953b
ToppCellHealthy_Control-Myeloid-Mast|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CPA3 ABCC4 FERMT2 CHRNA7

5.60e-06175304ca187074adcc9b8bd0fa270e2ede1564c8e6c6cf
ToppCellCOPD-Myeloid-Mast|World / Disease state, Lineage and Cell class

LRP4 CPA3 ABCC4 FERMT2

6.54e-0618230468a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP4 CPA3 ABCC4 FERMT2

6.98e-061853043fafb1d36c5f98a29d20a5ce5192c83d6f603514
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP4 CPA3 ABCC4 FERMT2

7.13e-06186304de55471dd5c842026b409cfebf67fe32f079a011
ToppCellCOPD-Myeloid-Mast|COPD / Disease state, Lineage and Cell class

LRP4 CPA3 ABCC4 FERMT2

7.13e-06186304def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell10x5'-Lung-Mast|Lung / Manually curated celltypes from each tissue

LRP4 CPA3 ABCC4 FERMT2

7.28e-06187304f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell10x5'-Lung-Mast-Mast_cells|Lung / Manually curated celltypes from each tissue

LRP4 CPA3 ABCC4 FERMT2

7.28e-06187304da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCellCOPD-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

LRP4 CPA3 ABCC4 FERMT2

7.75e-06190304379dbac19110b76079a7a53209569e060a852acb
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CPA3 LNPEP SYNE1 USP24

8.94e-0619730457ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

FUT11 LNPEP SYNE1 USP24

9.49e-062003042281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellPND01-Immune-Immune_Myeloid-Granulocytic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELL CPA3 SYNE1

1.33e-0414830374f1f9d1a53dc1a09cb6a504cbbdc7496c5b6879
ToppCellPND07-28-samps-Lymphocyte-T_cells|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SELL CPA3 CDC45

1.58e-04157303f3b4cde52423246ae6fc4924cd1ee502cf6c009c
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRP4 CPA3 FERMT2

1.80e-04164303b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRP4 CPA3 FERMT2

1.80e-04164303f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CPA3 ABCC4 FERMT2

1.86e-04166303c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL CNTNAP4 WDFY4

1.86e-04166303a8ba4d51e778634f8a7f47fa0d01a2019f774fb8
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELL CTRC WDFY4

1.86e-0416630300c53ee34ff4b988a9accd296bc0a2e14d9e7c49
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL CNTNAP4 WDFY4

1.86e-041663034906c85f52c3751166e296102d524a13b1f438f5
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL CNTNAP4 WDFY4

1.86e-0416630304e32bd32165cdf316f2a8709c3662d55cd70391
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELL WDFY4 CDC45

1.89e-0416730341675d15919104c9e20cd97620fe636f3ff33fa9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELL WDFY4 CDC45

1.89e-041673033d5a6a4c7d037b1a6a8ec90034d88ef6d256e843
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL CNTNAP4 WDFY4

1.93e-041683030ecc6503ea249a4b13c42cfec2b024338f7e6080
ToppCellASK428-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CPA3 ABCC4 FERMT2

1.93e-04168303c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Basophil|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELL CPA3 SYNE1

1.96e-04169303b23d0aaa2da333b9c69a7aee862d5a5d2a1bf79b
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELL CPA3 SYNE1

1.96e-0416930383d1bcf33872b01ea9614f608a3e4ab30df25c7e
ToppCellControl-Myeloid-Mast|Control / Disease state, Lineage and Cell class

CPA3 ABCC4 FERMT2

2.00e-041703039a14deb7f7cd4a49c217eba4023f7bf1dec6c902
ToppCellControl-Myeloid-Mast|World / Disease state, Lineage and Cell class

CPA3 ABCC4 FERMT2

2.03e-04171303ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-new-cluster|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 WDFY4 CDC45

2.03e-04171303d0d92eb5152410c3b4dd4a3f1dc3cca0e18a85fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELL WDFY4 CDC45

2.03e-04171303c60313b045cb77c0923ddb81bbd1a654aa1087c5
ToppCell3'_v3-GI_small-bowel-Lymphocytic_NK-NK_CD16|GI_small-bowel / Manually curated celltypes from each tissue

SELL SYNE1 CDC45

2.07e-04172303701de463f85aaad3a4b36a0d5fbc416406620089
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELL CPA3 SYNE1

2.10e-041733034282b47b33325472f52a4085986988911a372ed8
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELL CPA3 SYNE1

2.10e-041733038ca650542655c27516029e5bace97ff1b9dcc256
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 LRP4 ENPEP

2.14e-041743034cdf2eedc28d88d18241ee390092426fdf849e79
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 LRP4 ENPEP

2.14e-04174303268be5e7d2a18b866770b7cdb966c3958c7e6534
ToppCellCaecum-Dendritic_cell-cDC1|Dendritic_cell / Region, Cell class and subclass

SELL OSBPL9 WDFY4

2.21e-0417630307cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCellControl-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

CPA3 ABCC4 FERMT2

2.21e-041763030c5916d63e1ada09105e46d2429b75129b7329ec
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 ENPEP CHRNA7

2.32e-04179303c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCellImmune_cells-large_pre-B.|World / Lineage and Cell class

DRC7 WDFY4 ENPEP

2.48e-0418330381b5ed6ed661d2d6a9b807fefd2f0d59bd4ea77e
ToppCellCF-Myeloid-Neutrophil|CF / Disease state, Lineage and Cell class

SELL KIAA0825 USP32

2.48e-04183303da43827952e6fdee2ce94648c316182f272b321c
ToppCellIPF-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

CPA3 ABCC4 FERMT2

2.52e-041843037326a16d7d3ae41b8c9d2beaec7f977b374f3469
ToppCellIPF-Myeloid-Mast|IPF / Disease state, Lineage and Cell class

CPA3 ABCC4 FERMT2

2.52e-04184303c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCellIPF-Myeloid-Mast|World / Disease state, Lineage and Cell class

CPA3 ABCC4 FERMT2

2.52e-041843037aefa182acad5a53c730945fec85329d7168606a
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP4 CPA3 ABCC4

2.64e-04187303bdcef4f3e093c3646b639a189bbe93d6f4c40f3c
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP4 CPA3 ABCC4

2.64e-0418730309348f1e8bbbca8dca885461937b9b1dd248b034
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP4 CPA3 ABCC4

2.64e-041873030f7a42c55997e34a0d20e492e16b03e91e965335
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP4 CPA3 ABCC4

2.64e-04187303064730fa72f8637c3db3fc34d2e363d2b9a38f1d
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

PITPNM2 FERMT2 SYNE1

2.64e-0418730354d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SELL CPA3 ENPEP

2.68e-0418830388b808561ebde997ac8a8bbd1d9bbda49bbb6646
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP4 CPA3 ABCC4

2.72e-04189303f01158bb15df3117fae1271bf8cf8c2501422671
ToppCellASK440-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CPA3 ABCC4 FERMT2

2.72e-0418930372a19b20cb0f7283afe5f85d62a21cff69fd78d0
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP4 CPA3 FERMT2

2.77e-041903037774dc0b4ae7d5920b516800f3b90cbf831f8d3d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 RNF7 ABHD12

2.77e-0419030319faabab3f27579e380d2ac625876c6439933b44
ToppCellcontrol-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CPA3 ABCC4 FERMT2

2.81e-04191303afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP4 CPA3 ENPEP

2.81e-04191303beb5bb42bd53bce01339da9110d374901548793c
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP4 CPA3 ENPEP

2.81e-04191303b5210de890d338602857b5907135705a507bc2b0
ToppCellhematopoetic_progenitors-CD34+_MEP_2|hematopoetic_progenitors / Lineage and Cell class

LRP4 CPA3 FERMT2

2.81e-041913033b061dbc10918be7cbbd4453311d2c1ebf18c6b2
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP4 CPA3 ENPEP

2.81e-041913036609d85fd2577633dcc067507304a6f9e5865ca3
ToppCellPCW_10-12-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SELL CPA3 WDFY4

2.81e-0419130347f20686001f945bc31d5a0b974958e4009edb34
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP4 CPA3 ENPEP

2.81e-04191303d4f535b06ad483448ab692e9900c872c78cbed60
ToppCelldroplet-Lung-nan-18m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 FERMT2 ENPEP

2.85e-04192303c09966f4d63a739a56db4df7e0e0ee9ecacd21ad
ToppCelldroplet-Lung-nan-18m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 FERMT2 ENPEP

2.85e-04192303df56c3e3bb1aafc1126607f4426554c09c8c40cf
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 FERMT2 ENPEP

2.85e-04192303d22c1135867bcb9076435e2c6eb1cc1248990d0c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SELL CPA3 FERMT2

2.85e-041923033ce486cd5171f2d04ac4f7f87bead8b0d8c99c17
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSBPL9 ENPEP SYNE1

2.85e-041923031ccc47792edf9ee23501c8e2165d11271636b66a
ToppCelldroplet-Lung-nan-21m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 FERMT2 ENPEP

2.85e-04192303e429e8fbc48ad26204a0197b9129e58be56bd7b6
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 CPA3 ENPEP

2.90e-04193303fa45042d30f9cfeed10e23270a78f18551219cfa
ToppCelldroplet-Lung-nan-21m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 FERMT2 ENPEP

2.90e-041933037a09739d0b07dcd615cce2da93fd169cc92e566d
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 CPA3 ENPEP

2.90e-04193303027e098ad018e782287f84eee0f77551018f2196
ToppCelldroplet-Lung-nan-21m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 FERMT2 ENPEP

2.90e-04193303ac4270b26f5dc7ff2220a109e5aae5a113893211
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LNPEP SYNE1 USP24

2.90e-041933039337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 CPA3 ENPEP

2.90e-04193303ab511ea9e09216a965b3ae5a94f8c3c1ae33d944
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 CPA3 ENPEP

2.90e-04193303c5463a87f20b3a7f7ffda677b2f5a0e9e49d6685
ToppCell3'_v3-Lung-Mast|Lung / Manually curated celltypes from each tissue

CPA3 ABCC4 FERMT2

2.94e-041943035e6eb81ddc9d5e22c1297734689f476d5a05bff6
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PITPNM2 ABCC4 SYNE1

2.94e-0419430397534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell3'_v3-Lung-Mast-Mast_cells|Lung / Manually curated celltypes from each tissue

CPA3 ABCC4 FERMT2

2.94e-041943037b7f1714c4a9d9519c4d0e460cb87f2eb82392dd
ToppCellSevere_COVID-19-T/NK-NK|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PITPNM2 LNPEP SYNE1

3.08e-04197303cc20162892b59e48653981f91fc9a0c27064444d
ToppCellCOVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

FUT11 LNPEP SYNE1

3.08e-04197303d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SELL PTGES3 SYNE1

3.12e-041983034c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell10x5'v1-week_14-16-Mesenchymal_myocytic-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRP4 ATP1B4 FERMT2

3.12e-041983038602a518b5913625b1dd3cbc3c7e6efde0d5d942
ToppCell10x5'v1-week_14-16-Mesenchymal_myocytic|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRP4 ATP1B4 FERMT2

3.12e-0419830355d2ed345101bec4b73f1242ba8c4d73073b7e88
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LRP4 SYNE1 USP24

3.17e-0419930319a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SELL WDFY4 TIGD6

3.17e-041993037271dbeca9aa838b88ad44d00059263a29c0316b
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

FUT11 LNPEP SYNE1

3.17e-04199303df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCellCOVID_vent-Lymphocytic-ILC|COVID_vent / Disease condition, Lineage, Cell class and subclass

FUT11 LNPEP SYNE1

3.17e-04199303e3ff7fa1b1de1aaf6b46cdf49afa95bad457728a
ToppCellCOVID-19-COVID-19_Mild-Myeloid-Neutrophil|COVID-19_Mild / Disease, condition lineage and cell class

SELL CPA3 KIAA0825

3.17e-041993039f6b6731186ef399f952a75879eba66fd8ed3494
ToppCellCOVID_vent-Lymphocytic-ILC-NK_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

FUT11 LNPEP SYNE1

3.17e-041993035f914962e2572b0c6372465b81b7496fa663d93c
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

FUT11 LNPEP SYNE1

3.17e-04199303ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCell(7)_Mast_cell|World / shred on Cell_type and subtype

CPA3 ABCC4 FERMT2

3.17e-04199303c0b5f1cb435da99a7e2ebac9ee7d7b1bd0e49b42
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Intermediate|GW10 / Sample Type, Dataset, Time_group, and Cell type.

SELL FUT11 KIAA0825

3.17e-04199303cf592d93612023a13de21e0fb8c6b13714f9af71
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma|TCGA-Liver / Sample_Type by Project: Shred V9

PTGES3 ABHD12 TIGD6

3.22e-042003039cff8be6e566f342fc8b45e93106d033b14759ee
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SELL LRP4 CPA3

3.22e-042003030b02f3ca3d8612ed7af46381195b0ed5591313cf
ToppCellCaecum-(7)_Mast_cell|Caecum / shred on region, Cell_type, and subtype

CPA3 ABCC4 FERMT2

3.22e-04200303d23fe8644ce42ace51fcde43cb4cd22a99300c02
ToppCellCaecum-Mast_cell|Caecum / Region, Cell class and subclass

CPA3 ABCC4 FERMT2

3.22e-042003038791d0b3d883e7a747a23d21118817f5be4013b6
ToppCellCaecum-(7)_Mast_cell-(70)_Mast|Caecum / shred on region, Cell_type, and subtype

CPA3 ABCC4 FERMT2

3.22e-042003039974285c28a633a010c4f24d035ad3685705e881
ToppCellBiopsy_Control_(H.)-Immune-Mast_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

LRP4 CPA3 ABCC4

3.22e-0420030364bf125e0e5652a5a638a6bb32eb109cb0d5e232
Diseaseairway responsiveness measurement

ABCC4 WDFY4 USP24

1.70e-0624293EFO_0006897
Diseaseendoplasmic reticulum aminopeptidase 1 measurement

ERAP1 LNPEP

1.95e-057292EFO_0008119
Diseasesevere pre-eclampsia (is_marker_for)

ERAP1 LNPEP

2.60e-058292DOID:13129 (is_marker_for)
DiseaseMemory Disorders

LNPEP CHRNA7

8.21e-0443292C0025261
DiseaseMemory Loss

LNPEP CHRNA7

8.21e-0443292C0751295
DiseaseAge-Related Memory Disorders

LNPEP CHRNA7

8.21e-0443292C0751292
DiseaseMemory Disorder, Spatial

LNPEP CHRNA7

8.21e-0443292C0751294
DiseaseMemory Disorder, Semantic

LNPEP CHRNA7

8.21e-0443292C0751293
DiseaseMemory impairment

LNPEP CHRNA7

8.60e-0444292C0233794
DiseaseJT interval

FERMT2 PTGES3 CREBBP

1.82e-03248293EFO_0007885
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PITPNM2 LRP4 USP24

2.18e-03264293EFO_0008317, EFO_0020944
DiseaseAntihypertensive use measurement

KIAA0825 PTGES3 ENPEP

2.20e-03265293EFO_0009927
Diseasecalcium measurement

PITPNM2 CPA3 RNF7 ABCC4

3.16e-03628294EFO_0004838

Protein segments in the cluster

PeptideGeneStartEntry
WQYVDDVWLMFNNAW

CREBBP

1151

Q92793
SGWNWKQYRQEDSIW

CNTNAP4

116

Q9C0A0
AWWQKLQIMSEYLWD

ATP1B4

81

Q9UN42
IWLQMSWTDHYLQWN

CHRNA7

76

P36544
SLKKWNAVAMWSWDV

RNF7

31

Q9UBF6
KWTNVMKGWQYRWFV

OSBPL9

11

Q96SU4
AVWWKNAQGKDQMWY

ABHD12

146

Q8N2K0
NMLDQSAITKWNWNW

KIAA0825

1201

Q8IV33
WYQSMFNWNPWLTTL

ERVS71-1

561

P61550
MEWWNDLWLNEGFAK

ERAP1

366

Q9NZ08
QRDLWNIFKLWGWTM

SELL

11

P14151
FGNLVTMKWWNDLWL

LNPEP

471

Q9UIQ6
TMKWWNDLWLNEGFA

LNPEP

476

Q9UIQ6
SYGKNMAWNWIQLNW

ENPEP

861

Q07075
MAWNWIQLNWDYLVN

ENPEP

866

Q07075
QAWCWQDEWYGLSME

PITPNM2

226

Q9BZ72
QDWWLSYWANKQSML

ABCC4

731

O15439
AWMLSKDLNDMLWWA

CDC45

206

O75419
WPWQISLQYLKNDTW

CTRC

41

Q99895
DGYIWSWTKNRMWRK

CPA3

221

P15088
WKEMWLQDYWQGLDQ

FUT11

446

Q495W5
LWNHKNYWINMQDCW

DRC7

341

Q8IY82
TWRFSNMKQWNVNWE

FERMT2

606

Q96AC1
LMWDHAKQSLFNWLW

ORC2

431

Q13416
NQWAWMTRDLFNEWL

TIGD6

251

Q17RP2
KWQQFNSDLNSIWAW

SYNE1

8441

Q8NF91
LQAWKERWSDYQWAI

MED24

11

O75448
WTDWNNMSKFFQYGW

C11orf1

41

Q9H5F2
LNWLSVDFNNWKDWE

PTGES3

96

Q15185
TMWAWNARNFFLLEW

WDFY4

411

Q6ZS81
WAVQWLQKKMSEHYW

USP24

2526

Q9UPU5
WNWAFGVCNMYWKEK

TRIM49B

351

A6NDI0
WFIISMQWWQQWKEY

USP32

396

Q8NFA0
MQWWQQWKEYVKYDA

USP32

401

Q8NFA0
ALTQQDRWIYWTDWQ

LRP4

1561

O75096