Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium channel inhibitor activity	NEDD4L NEDD4	1.84e-04	8	52	2	GO:0019871
Domain	HECT	NEDD4L NEDD4	2.65e-03	27	53	2	PF00632
Domain	HECTc	NEDD4L NEDD4	2.65e-03	27	53	2	SM00119
Domain	HECT_dom	NEDD4L NEDD4	2.65e-03	27	53	2	IPR000569
Domain	HECT	NEDD4L NEDD4	2.65e-03	27	53	2	PS50237
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	NEDD4L SCN8A NEDD4	9.45e-07	13	53	3	15123669
Pubmed	Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.	NEDD4L NEDD4	2.28e-06	2	53	2	11502596
Pubmed	Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.	NEDD4L NEDD4	2.28e-06	2	53	2	23262292
Pubmed	Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.	NEDD4L NEDD4	2.28e-06	2	53	2	37962894
Pubmed	Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.	NEDD4L NEDD4	2.28e-06	2	53	2	19602703
Pubmed	A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.	NEDD4L NEDD4	2.28e-06	2	53	2	11149908
Pubmed	Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.	NEDD4L NEDD4	2.28e-06	2	53	2	31802037
Pubmed	Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.	NEDD4L NEDD4	6.83e-06	3	53	2	11779188
Pubmed	Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.	NEDD4L NEDD4	6.83e-06	3	53	2	18498246
Pubmed	Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.	NEDD4L NEDD4	6.83e-06	3	53	2	21852580
Pubmed	The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.	NEDD4L NEDD4	6.83e-06	3	53	2	22361880
Pubmed	Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.	NEDD4L NEDD4	6.83e-06	3	53	2	15217910
Pubmed	Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.	NEDD4L NEDD4	6.83e-06	3	53	2	12729930
Pubmed	Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.	NEDD4L NEDD4	6.83e-06	3	53	2	19423771
Pubmed	Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.	NEDD4L NEDD4	6.83e-06	3	53	2	12050153
Pubmed	Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.	NEDD4L NEDD4	6.83e-06	3	53	2	20730100
Pubmed	Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1.	NEDD4L NEDD4	6.83e-06	3	53	2	26823285
Pubmed	Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.	NEDD4L NEDD4	6.83e-06	3	53	2	23686771
Pubmed	14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.	NEDD4L NEDD4	6.83e-06	3	53	2	15677482
Pubmed	Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.	SPTBN4 SCN8A	6.83e-06	3	53	2	16033895
Pubmed	[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier.	SPTBN4 SCN8A	6.83e-06	3	53	2	11807096
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	DXO PGS1 ICAM5 POLD1 CTDP1 TAP2 FBXL6 NEDD4 TEDC1	9.94e-06	925	53	9	28986522
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	NEDD4L NEDD4	1.36e-05	4	53	2	27466427
Pubmed	SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.	NEDD4L NEDD4	1.36e-05	4	53	2	28608480
Pubmed	GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.	NEDD4L NEDD4	1.36e-05	4	53	2	17544362
Pubmed	The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.	NEDD4L NEDD4	1.36e-05	4	53	2	20026598
Pubmed	C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.	NEDD4L NEDD4	1.36e-05	4	53	2	31357244
Pubmed	Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.	NEDD4L NEDD4	1.36e-05	4	53	2	29897283
Pubmed	NEDD4-2 associates with gamma(c) and regulates its degradation rate.	NEDD4L NEDD4	1.36e-05	4	53	2	19615332
Pubmed	Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.	NEDD4L NEDD4	1.36e-05	4	53	2	22024150
Pubmed	Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.	NEDD4L NEDD4	1.36e-05	4	53	2	11696533
Pubmed	Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.	NEDD4L NEDD4	1.36e-05	4	53	2	21463633
Pubmed	Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.	SCN8A NEDD4	1.36e-05	4	53	2	20530479
Pubmed	Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.	NEDD4L NEDD4	2.27e-05	5	53	2	15548568
Pubmed	Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.	NEDD4L NEDD4	2.27e-05	5	53	2	25157163
Pubmed	Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.	NEDD4L NEDD4	2.27e-05	5	53	2	30287686
Pubmed	An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.	NEDD4L NEDD4	2.27e-05	5	53	2	18687683
Pubmed	Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.	NEDD4L NEDD4	2.27e-05	5	53	2	27793840
Pubmed	The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.	NEDD4L NEDD4	2.27e-05	5	53	2	22385262
Pubmed	Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.	NEDD4L NEDD4	2.27e-05	5	53	2	21478478
Pubmed	NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.	NEDD4L NEDD4	2.27e-05	5	53	2	31867777
Pubmed	A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline.	NEDD4L NEDD4	2.27e-05	5	53	2	36002265
Pubmed	The ESCRT pathway and HIV-1 budding.	NEDD4L NEDD4	2.27e-05	5	53	2	19143627
Pubmed	Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.	NEDD4L NEDD4	2.27e-05	5	53	2	19706893
Pubmed	Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.	NEDD4L NEDD4	2.27e-05	5	53	2	19617352
Pubmed	Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.	NEDD4L NEDD4	2.27e-05	5	53	2	25631046
Pubmed	The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.	NEDD4L NEDD4	2.27e-05	5	53	2	18577513
Pubmed	The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.	NEDD4L NEDD4	2.27e-05	5	53	2	17289006
Pubmed	N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.	NEDD4L NEDD4	3.40e-05	6	53	2	15252135
Pubmed	Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.	NEDD4L NEDD4	3.40e-05	6	53	2	37156795
Pubmed	Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).	NEDD4L NEDD4	3.40e-05	6	53	2	27445338
Pubmed	Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination.	NEDD4L NEDD4	3.40e-05	6	53	2	16701206
Pubmed	Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.	NEDD4L NEDD4	3.40e-05	6	53	2	26854353
Pubmed	β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.	NEDD4L NEDD4	3.40e-05	6	53	2	29964046
Pubmed	N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.	NEDD4L NEDD4	3.40e-05	6	53	2	11748237
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	NEDD4L NEDD4	4.76e-05	7	53	2	30587574
Pubmed	Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.	NEDD4L NEDD4	4.76e-05	7	53	2	11046148
Pubmed	Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.	NEDD4L NEDD4	4.76e-05	7	53	2	23644597
Pubmed	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	NEDD4L NEDD4	4.76e-05	7	53	2	20051513
Pubmed	HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.	NEDD4L NEDD4	4.76e-05	7	53	2	20086093
Pubmed	Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.	NEDD4L NEDD4	4.76e-05	7	53	2	24831002
Pubmed	The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.	NEDD4L NEDD4	4.76e-05	7	53	2	16337426
Pubmed	FBXL6 degrades phosphorylated p53 to promote tumor growth.	IRS4 FBXL6	6.34e-05	8	53	2	33568778
Pubmed	The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.	NEDD4L NEDD4	6.34e-05	8	53	2	11244092
Pubmed	Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.	NEDD4L NEDD4	6.34e-05	8	53	2	24036464
Pubmed	Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.	NEDD4L NEDD4	6.34e-05	8	53	2	17719543
Pubmed	Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.	NEDD4L NEDD4	8.15e-05	9	53	2	18981174
Pubmed	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.	NEDD4L NEDD4	8.15e-05	9	53	2	15496141
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	NEDD4L NEDD4	1.02e-04	10	53	2	25092867
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	NEDD4L NEDD4	1.24e-04	11	53	2	22773947
Pubmed	Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.	NEDD4L NEDD4	1.24e-04	11	53	2	21505443
Pubmed	Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.	NEDD4L NEDD4	1.24e-04	11	53	2	25963657
Pubmed	Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21).	TNRC18 WDFY3	1.49e-04	12	53	2	15271968
Pubmed	The mouse as a model for the effects of MHC genes on human disease.	DXO C6orf47 TAP2	1.49e-04	67	53	3	10871872
Pubmed	Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.	NEDD4L NEDD4	1.76e-04	13	53	2	23146885
Pubmed	Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.	NEDD4L NEDD4	2.36e-04	15	53	2	23236378
Pubmed	A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region.	IGLL5 GSC2	2.36e-04	15	53	2	9037598
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TNRC18 ARHGEF40 ARAP3 MROH6 NEK8 CTDP1 SCN8A WDFY3	2.52e-04	1105	53	8	35748872
Pubmed	Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.	NEDD4L NEDD4	2.70e-04	16	53	2	21920314
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	NEDD4L NEDD4	3.05e-04	17	53	2	28292929
Pubmed	Wrapping up the bad news: HIV assembly and release.	NEDD4L NEDD4	3.43e-04	18	53	2	23305486
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	NEDD4L NEDD4	3.83e-04	19	53	2	21572392
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	NEDD4L NEDD4	4.70e-04	21	53	2	37005481
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	NEDD4L NEDD4	4.70e-04	21	53	2	29416926
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TNRC18 IRS4 NEDD4L CCDC87 NEDD4	4.97e-04	430	53	5	35044719
Pubmed	Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.	ARAP3 EXOC3L1	5.65e-04	23	53	2	22535667
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	NEDD4L NEDD4	6.68e-04	25	53	2	23873930
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	NEDD4L NEDD4	7.23e-04	26	53	2	26949039
Pubmed	Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry.	SCN8A NEDD4	7.23e-04	26	53	2	10591541
Pubmed	NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.	NEDD4L NEDD4	7.80e-04	27	53	2	28931009
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	NEDD4L POLD1 SLC2A11 NEDD4	1.33e-03	313	53	4	38270169
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	TPO ARAP3 NEDD4L TIE1 NEDD4	2.45e-06	181	53	5	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 NEDD4L TIE1 EXOC3L1 NEDD4	3.35e-06	193	53	5	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 NEDD4L TIE1 EXOC3L1 NEDD4	3.35e-06	193	53	5	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 NEDD4L TIE1 EXOC3L1 NEDD4	3.35e-06	193	53	5	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	proximal-3-Hematologic-Interstitial_Macrophage\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MPEG1 IRGQ PEAK3 IGLL5 PTGDR2	3.61e-06	196	53	5	d8c9cb86233470c3044865ad05ea202e294d80bf
ToppCell	proximal-Hematologic-Interstitial_Macrophage-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MPEG1 IRGQ PEAK3 IGLL5 PTGDR2	3.61e-06	196	53	5	9d4d8ffe9d30de7d1dc33d261bc2aaf4189ad86c
ToppCell	proximal-Hematologic-Interstitial_Macrophage\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MPEG1 IRGQ PEAK3 IGLL5 PTGDR2	3.61e-06	196	53	5	b6a858c43fef42cd724d56c8283e954bcb546106
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ABHD15 POLD1 MPEG1 PCSK1N IGLL5	3.89e-06	199	53	5	f197ab861767ee06aa47b86c537fb3d8c2b2bc3e
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TPO ARAP3 TIE1 EXOC3L1	2.34e-05	140	53	4	b9aeb7dda7f377b580dd8a44912f300721437387
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABHD15 NEK8 MPEG1 IGLL5	4.13e-05	162	53	4	f12c08d0d4406f9560ecfc3bc2ff38c3bc58f184
ToppCell	NS-critical-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABHD15 MPEG1 IGLL5 PTGDR2	4.44e-05	165	53	4	17d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SSC5D FBXL6 KIF7 TEDC1	4.65e-05	167	53	4	f4943fb5001475ddab82a0273bcbb3fa68fdd7bd
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRC14B ABHD15 MPEG1 IGLL5	5.22e-05	172	53	4	b84610f1e5889a655652800c2b3270d264bfe1a9
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARAP3 TIE1 EXOC3L1 TAP2	5.34e-05	173	53	4	66488d01e03264fb193285470901c9c4182fbae8
ToppCell	Healthy_Control-Myeloid-Mast-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ARHGEF40 TIE1 CYP4F11 PTGDR2	5.58e-05	175	53	4	eadbbcdf2aef4cee268bc70a7a2c4175d898953b
ToppCell	Healthy_Control-Myeloid-Mast\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ARHGEF40 TIE1 CYP4F11 PTGDR2	5.58e-05	175	53	4	ca187074adcc9b8bd0fa270e2ede1564c8e6c6cf
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	TMEM201 TNRC18 POLD1 NCCRP1	5.96e-05	178	53	4	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	moderate-Myeloid-pDC\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ABHD15 NEK8 MPEG1 IGLL5	6.23e-05	180	53	4	a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell	NS-moderate-d_16-33-Myeloid-pDC\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABHD15 NEK8 MPEG1 IGLL5	6.23e-05	180	53	4	144818e69613296cde43f29cb8c20899c670b319
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF40 MPEG1 WDFY3 IRGQ	6.36e-05	181	53	4	2b9b460239d67fd480cee60820cdb306109d3567
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGEF40 MPEG1 WDFY3 IRGQ	6.36e-05	181	53	4	2a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF40 ARAP3 TIE1 EXOC3L1	6.50e-05	182	53	4	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF40 ARAP3 TIE1 EXOC3L1	6.50e-05	182	53	4	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF40 ARAP3 TIE1 EXOC3L1	6.50e-05	182	53	4	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF40 ARAP3 TIE1 EXOC3L1	6.92e-05	185	53	4	512a195ebbae445afe3722a3943020080daf2f3c
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	TPO ARAP3 TIE1 NEDD4	7.22e-05	187	53	4	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 TIE1 EXOC3L1 NEDD4	7.52e-05	189	53	4	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TPO ARAP3 TIE1 NEDD4	7.68e-05	190	53	4	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TPO ARAP3 TIE1 NEDD4	7.83e-05	191	53	4	f229abf69a1217194f74b0502486907e07dba989
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ARAP3 TIE1 EXOC3L1 NEDD4	8.15e-05	193	53	4	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 TIE1 EXOC3L1 NEDD4	8.32e-05	194	53	4	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 TIE1 EXOC3L1 NEDD4	8.32e-05	194	53	4	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	wk_20-22-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	NEDD4L GGT6 ICAM5 FREM3	8.65e-05	196	53	4	e24a7aaf41793abba66c1189d933ca05b14c1af9
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	POLD1 MPEG1 PCSK1N IGLL5	8.83e-05	197	53	4	8fa38fb95e285f9cc756ec4f32009be4ede09d3c
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_capillary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARAP3 TIE1 EXOC3L1 NEDD4	8.83e-05	197	53	4	81718164c9802ee20c860ffbda7e62d5e9a76f16
Disease	Liddle syndrome (implicated_via_orthology)	NEDD4L NEDD4	1.68e-05	4	50	2	DOID:0050477 (implicated_via_orthology)
Disease	left ventricular ejection fraction measurement	NEDD4L ALPK3	2.11e-03	40	50	2	EFO_0008373
Disease	Cleft palate, isolated	NEDD4L KIF7	2.32e-03	42	50	2	C1837218
Disease	immunoglobulin isotype switching measurement	TAP2 TEDC1	2.54e-03	44	50	2	EFO_0010128
Disease	left ventricular systolic function measurement	NEDD4L ALPK3	2.54e-03	44	50	2	EFO_0008206
Disease	major depressive episode	PEAK3 FREM3	2.90e-03	47	50	2	EFO_0007634
Disease	complement C4 measurement	DXO TAP2	3.53e-03	52	50	2	EFO_0004984
Disease	nervous system disorder	SCN8A TTC19	3.67e-03	53	50	2	C0027765

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPAPGALPGWLEALR	EXOC3L1	266	Q86VI1
GPAPLRLLEWRVAAG	CTDP1	26	Q9Y5B0
EHVLLGRARGPDGPW	ARHGEF40	1056	Q8TER5
GPGLLRLGRLWLRSP	ARAP3	796	Q8WWN8
GPGLLWLEEGPRQSL	CTCFL	116	Q8NI51
WLEGRGLPPLLGSVD	ALG1L2	131	C9J202
VPGRGLVLWLPGLPR	ALPK3	26	Q96L96
GPDAGWGDRIPLEIL	FBXL6	106	Q8N531
REGWRLADELGLPPL	CCDC87	316	Q9NVE4
ALLGLLGPRLRGPWG	ABHD15	16	Q6UXT9
PVLEVLPGGGWDNLR	MPEG1	41	Q2M385
PLPPGWEERQDILGR	NEDD4	611	P46934
EWGPLSGGLELPQRL	NCCRP1	76	Q6ZVX7
LLWGPRAGGVGLLVL	PCSK1N	6	Q9UHG2
PGLRRALLGLWAALG	ICAM5	6	Q9UMF0
PVFWRRLLGLLPGRP	PGS1	11	Q32NB8
LRGRGAPLGPWLRAL	PEAK3	406	Q6ZS72
PWTLLRGGGLDPLIR	TPO	526	P07202
LRLELVRPGWGGPRL	KIF7	536	Q2M1P5
GRLILWEAPPLGAGG	NEK8	351	Q86SG6
RWPLEEFRLGALLGP	LRRC14B	56	A6NHZ5
PWLLHLPGSGRLVEG	GGACT	51	Q9BVM4
GDPEPTVRWLGLLGL	MROH6	411	A6NGR9
EEPRGPARLLGWLLG	PTGDR2	361	Q9Y5Y4
LEHRGRLEGGPGWLA	DXO	111	O77932
LGPGPRQRWPLLLLG	IGLL5	16	B9A064
VGLRELLGGPQAWPL	SLC2A11	176	Q9BYW1
LGARLAWPLRLGPAV	GSC2	86	O15499
GAELRRWPLGPIDVL	GLYCTK	431	Q8IVS8
REKLLGWLRGEPGAP	C6orf47	151	O95873
RPGREEAGDLPVLLW	FUT11	66	Q495W5
ARFGRLPWPRLLVGP	GGT6	191	Q6P531
LRAEGGLWLRVEPLG	CYP4F11	506	Q9HBI6
EGQPLRLGPGLEVWA	MBLAC1	151	A4D2B0
GLRWGEPEPFLRLAL	POLD1	341	P28340
PGGLPGLCEWLRRAL	IRGQ	436	Q8WZA9
LGLVPLEPGGWLRRS	IRS4	361	O14654
NPGLRVPLGRSLWLD	FREM3	66	P0C091
RWDGRGEGLLIDQPL	HSF5	31	Q4G112
LPQGLPGLWLEGTLR	TAP2	31	Q03519
PGLGRDRDAWLPGEL	SSC5D	586	A1L4H1
LLLREDPGAGGWQEP	TNRC18	2481	O15417
GRGPGLLPLLAALAW	TTC19	51	Q6DKK2
LLRERGLWGPPIGSH	WDFY3	2351	Q8IZQ1
VPGPLVGDGFLLRLW	TIE1	571	P35590
WLRGLPPESTRLPGL	REXO5	681	Q96IC2
FLPWVPERGGGELDL	TEDC1	346	Q86SX3
GWDGLLLPILNRPPD	SCN8A	1706	Q9UQD0
GAELGPGLALDEWLP	SPTBN4	1161	Q9H254
PGAEGWRQLLGLLPE	TMEM201	266	Q5SNT2
PWGPRTLGLELRGVR	SIGLEC11	311	Q96RL6
LTLRPGWPRGLFRLG	TTC31	366	Q49AM3
DLGPLPPGWEERIHL	NEDD4L	546	Q96PU5