Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	3M complex	CCDC8 CUL7	1.86e-04	5	91	2	GO:1990393
GeneOntologyCellularComponent	acrosomal vesicle	HEXB SPATA31A1 SPATA31A3 SPATA31A7 PCSK4 SPATA31A5	2.83e-04	206	91	6	GO:0001669
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.94e-05	12	85	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.94e-05	12	85	3	IPR027970
Domain	MSC	LEMD3 LEMD2	2.05e-05	2	85	2	PF09402
Domain	Inner-Nucl-membr_MAN1	LEMD3 LEMD2	2.05e-05	2	85	2	IPR018996
Domain	Rho_GTPase_act	ARHGAP12 ARHGAP9	1.22e-04	4	85	2	IPR015767
Domain	LEM	LEMD3 LEMD2	2.03e-04	5	85	2	SM00540
Domain	LEM/LEM-like_dom	LEMD3 LEMD2	4.24e-04	7	85	2	IPR011015
Domain	LEM_dom	LEMD3 LEMD2	4.24e-04	7	85	2	IPR003887
Domain	LEM	LEMD3 LEMD2	4.24e-04	7	85	2	PS50954
Domain	-	LEMD3 LEMD2	4.24e-04	7	85	2	1.10.720.40
Domain	LEM	LEMD3 LEMD2	4.24e-04	7	85	2	PF03020
Domain	Iontro_rcpt	GRIN2C GRIN3B	2.99e-03	18	85	2	IPR001320
Domain	ALDEHYDE_DEHYDR_GLU	ALDH16A1 ALDH4A1	2.99e-03	18	85	2	PS00687
Domain	Lig_chan-Glu_bd	GRIN2C GRIN3B	2.99e-03	18	85	2	PF10613
Domain	Iono_rcpt_met	GRIN2C GRIN3B	2.99e-03	18	85	2	IPR001508
Domain	Glu/Gly-bd	GRIN2C GRIN3B	2.99e-03	18	85	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIN2C GRIN3B	2.99e-03	18	85	2	SM00918
Domain	Lig_chan	GRIN2C GRIN3B	2.99e-03	18	85	2	PF00060
Domain	PBPe	GRIN2C GRIN3B	2.99e-03	18	85	2	SM00079
Domain	ALDEHYDE_DEHYDR_CYS	ALDH16A1 ALDH4A1	2.99e-03	18	85	2	PS00070
Domain	Ald_DH_C	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	IPR016163
Domain	Ald_DH_N	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	IPR016161
Domain	-	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	3.40.605.10
Domain	Aldedh	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	PF00171
Domain	Aldehyde_DH_dom	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	IPR015590
Domain	-	ALDH16A1 ALDH4A1	3.33e-03	19	85	2	3.40.309.10
Domain	PH	CNKSR1 ARHGAP12 ARHGAP9 PLCD1 PLEKHD1	3.93e-03	229	85	5	PF00169
Domain	-	CUL7 HECTD1 PCSK4	4.50e-03	73	85	3	2.60.120.260
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	LPIN3 POM121 LEMD3 LEMD2 POM121C	3.69e-06	53	63	5	M27212
Pathway	REACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA	LPIN3 LEMD3 LEMD2	3.73e-05	15	63	3	M27360
Pathway	REACTOME_LEUKOTRIENE_RECEPTORS	GPR17 LTB4R2	1.95e-04	5	63	2	M27305
Pathway	REACTOME_LEUKOTRIENE_RECEPTORS	GPR17 LTB4R2	1.95e-04	5	63	2	MM15013
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	7.80e-10	6	95	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	7.80e-10	6	95	4	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	5.32e-07	24	95	4	32212159
Pubmed	Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns.	TPSD1 PRSS41 TPSG1	2.34e-06	10	95	3	14583634
Pubmed	Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements.	SIM1 CNTN2 SLC17A6	4.27e-06	12	95	3	15134635
Pubmed	WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues.	SOST WNT5A	7.38e-06	2	95	2	34440994
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121 POM121C	2.21e-05	3	95	2	30802453
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121 POM121C	2.21e-05	3	95	2	35507432
Pubmed	A rare cause of syndromic short stature: 3M syndrome in three families.	CCDC8 CUL7	2.21e-05	3	95	2	33258289
Pubmed	The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway.	CCDC8 CUL7	2.21e-05	3	95	2	22156540
Pubmed	Three M Syndrome	CCDC8 CUL7	2.21e-05	3	95	2	20301654
Pubmed	Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth.	CCDC8 CUL7	2.21e-05	3	95	2	21737058
Pubmed	Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits.	SIM1 SLC17A6	2.21e-05	3	95	2	30282024
Pubmed	The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.	SIM1 SLC17A6	2.21e-05	3	95	2	35476640
Pubmed	Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.	CCDC8 CUL7	2.21e-05	3	95	2	23018678
Pubmed	Murine implantation serine proteinases 1 and 2: structure, function and evolution.	TPSD1 TPSG1	4.41e-05	4	95	2	16257142
Pubmed	The 3M complex maintains microtubule and genome integrity.	CCDC8 CUL7	4.41e-05	4	95	2	24793695
Pubmed	Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.	SIM1 SLC17A6	4.41e-05	4	95	2	37531957
Pubmed	Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.	POM121 POM121C	4.41e-05	4	95	2	17900573
Pubmed	Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships.	ARHGAP12 ARHGAP9	7.34e-05	5	95	2	12297274
Pubmed	Sim1 is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord.	SIM1 SLC17A6	7.34e-05	5	95	2	25652362
Pubmed	The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.	SDK1 SLC17A6	7.34e-05	5	95	2	34545809
Pubmed	Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation.	LEMD3 LEMD2	7.34e-05	5	95	2	19720741
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	POM121 ATXN2 LEMD3 WNT5A TMEM131 POM121C	8.74e-05	263	95	6	34702444
Pubmed	Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling.	WNT5A CNTN2	1.10e-04	6	95	2	14671310
Pubmed	New developments in the genetics and activation of mast cell proteases.	TPSD1 TPSG1	1.10e-04	6	95	2	12217407
Pubmed	Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin.	SIM1 SLC17A6	1.54e-04	7	95	2	24485459
Pubmed	HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.	GRIN2C GRIN3B	1.54e-04	7	95	2	22940423
Pubmed	Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.	GRIN2C GRIN3B	1.54e-04	7	95	2	22833210
Pubmed	Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.	GRIN2C GRIN3B	2.05e-04	8	95	2	8804048
Pubmed	The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.	GRIN2C GRIN3B	2.05e-04	8	95	2	8845955
Pubmed	HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.	GRIN2C GRIN3B	2.05e-04	8	95	2	8563977
Pubmed	HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.	GRIN2C GRIN3B	2.05e-04	8	95	2	8821747
Pubmed	Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.	GRIN2C GRIN3B	2.05e-04	8	95	2	7695237
Pubmed	Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.	GRIN2C GRIN3B	2.05e-04	8	95	2	8724036
Pubmed	Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury.	SIM1 SLC17A6	2.05e-04	8	95	2	35524138
Pubmed	Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.	GRIN2C GRIN3B	2.05e-04	8	95	2	8822372
Pubmed	Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.	GRIN2C GRIN3B	2.05e-04	8	95	2	10448428
Pubmed	Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.	GRIN2C GRIN3B	2.05e-04	8	95	2	8955056
Pubmed	Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.	GRIN2C GRIN3B	2.05e-04	8	95	2	10555109
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	POM121 ATXN2 LEMD2 DDX28	2.25e-04	108	95	4	19531213
Pubmed	D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.	GRIN2C GRIN3B	2.62e-04	9	95	2	22552781
Pubmed	Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability.	SIM1 SLC17A6	2.62e-04	9	95	2	27866798
Pubmed	Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.	GRIN2C GRIN3B	2.62e-04	9	95	2	21491143
Pubmed	N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.	GRIN2C GRIN3B	3.28e-04	10	95	2	19332541
Pubmed	Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2.	CNTN2 SLC17A6	3.28e-04	10	95	2	35115485
Pubmed	Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.	ALDH4A1 POLDIP2 TST	3.53e-04	50	95	3	26058080
Pubmed	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.	GRIN2C GRIN3B	4.00e-04	11	95	2	8581564
Pubmed	HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.	GRIN2C GRIN3B	4.00e-04	11	95	2	24739951
Pubmed	Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells.	GRIN2C GRIN3B	4.00e-04	11	95	2	16481105
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	HEXB CCDC8 POM121 ATXN2 LEMD3 ALDH16A1 TMEM131 POGLUT2 POM121C SLC3A2	4.33e-04	1007	95	10	34597346
Pubmed	Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.	CCDC8 KANSL1 SENP3 IQCN POLDIP2 HSPB8 DDX28	5.91e-04	523	95	7	11256614
Pubmed	Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.	GRIN2C GRIN3B	6.58e-04	14	95	2	15749123
Pubmed	Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.	TPSD1 KCNQ1	6.58e-04	14	95	2	23457544
Pubmed	Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport.	GRIN2C GRIN3B	7.57e-04	15	95	2	21948112
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	POM121 POM121C	7.57e-04	15	95	2	14697343
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	IVD ABCB10 ATXN2 LEMD3 ARHGAP12 TIMM50 PEX6 TMEM131 ALDH4A1 POLDIP2 CUL7 DDX28	7.75e-04	1496	95	12	32877691
Pubmed	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	PLCD1 GRIN3B SDK1	8.33e-04	67	95	3	20398908
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	WNT5A CNTN2	8.64e-04	16	95	2	24305805
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	GRIN2C GRIN3B	9.78e-04	17	95	2	24086760
Pubmed	Genome-wide association analysis of age-at-onset in Alzheimer's disease.	LEMD2 SLC28A1	9.78e-04	17	95	2	22005931
Pubmed	An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.	CCDC8 CUL7	9.78e-04	17	95	2	21572988
Pubmed	Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.	WNT5A CNTN2	9.78e-04	17	95	2	21316586
Pubmed	The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance.	SIM1 CNTN2	1.10e-03	18	95	2	21068056
Pubmed	Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.	CNTN2 SLC17A6	1.10e-03	18	95	2	22090513
Pubmed	CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.	CCDC8 CUL7	1.10e-03	18	95	2	29507117
Pubmed	Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon.	SIM1 SLC17A6	1.10e-03	18	95	2	17611227
Pubmed	A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei.	SIM1 SLC17A6	1.10e-03	18	95	2	20495559
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	CCDC8 ABCB10 LEMD3 SENP3 TIMM50 TMEM131 POLDIP2 POM121C SLC3A2	1.19e-03	952	95	9	38569033
Pubmed	Functional proteomics mapping of a human signaling pathway.	CNKSR1 KANSL1 LEMD3 SENP3 PEX6 ARHGAP9 SDK1	1.20e-03	591	95	7	15231748
Pubmed	Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation.	HEXB CLN5	1.22e-03	19	95	2	29514215
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	ABCB10 SENP3 ALDH4A1 POLDIP2 TST SLC3A2	1.30e-03	438	95	6	32628020
Pubmed	Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain.	SIM1 SLC17A6	1.36e-03	20	95	2	25392491
Pubmed	Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression.	CNTN2 SLC17A6	1.36e-03	20	95	2	20696379
Pubmed	Plexin-B2 controls the development of cerebellar granule cells.	CNTN2 SLC17A6	1.50e-03	21	95	2	17409257
Pubmed	The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.	GRIN2C GRIN3B	1.50e-03	21	95	2	22114277
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	POM121 ATXN2 LEMD3 ALDH16A1 LEMD2 POM121C	1.62e-03	457	95	6	32344865
Pubmed	Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.	ANO4 WNT5A	1.80e-03	23	95	2	37873566
Pubmed	Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.	ALDH16A1 ALDH4A1	1.80e-03	23	95	2	18971422
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CCDC8 CILP TIMM50 NINL POLDIP2 CUL7 HECTD1	1.87e-03	639	95	7	23443559
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN2C GRIN3B	1.96e-03	24	95	2	35746896
Pubmed	Identification of a large set of rare complete human knockouts.	TPSD1 GRIN3B	1.96e-03	24	95	2	25807282
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	CPAMD8 NBEAL2 SLC28A1 NINL JMJD4 ARHGAP9 GRIN2C GRIN3B	2.02e-03	832	95	8	36724073
Pubmed	RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.	DLGAP4 PLCD1 SLC3A2	2.08e-03	92	95	3	23055941
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	GPR17 P2RY6 LTB4R2	2.28e-03	95	95	3	16754659
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	GRIN2C GRIN3B	2.30e-03	26	95	2	9745929
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	CCDC8 CUL7	2.66e-03	28	95	2	25752541
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	POM121 ATXN2 WNT5A	2.71e-03	101	95	3	26949739
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.18e-04	8	95	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	1.14e-03	24	95	2	9p13.1
Cytoband	16p13.3	TPSD1 C16orf90 PRSS41 TPSG1	1.70e-03	244	95	4	16p13.3
GeneFamily	LEM domain containing	LEMD3 LEMD2	2.18e-04	7	59	2	1087
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN3B	2.18e-04	7	59	2	1201
GeneFamily	Aldehyde dehydrogenases	ALDH16A1 ALDH4A1	1.73e-03	19	59	2	398
Coexpression	GSE36392_MAC_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP	ABCB10 NBEAL2 DLGAP4 SENP3 JMJD4 TMC4 ZNF229	7.38e-06	200	93	7	M5285
Drug	oxiracetam	GRIN2C GRIN3B TPSG1	9.96e-06	11	91	3	CID000004626
Drug	fluorescein mono-p-guanidinobenzoate	TPSD1 TPSG1	1.58e-05	2	91	2	CID000134314
Drug	adelmidrol	TPSD1 TPSG1	1.58e-05	2	91	2	CID000176874
Drug	hexaminolevulinate	TPSD1 TPSG1	1.58e-05	2	91	2	CID006433082
Drug	tele-methylhistamine	TPSD1 ARHGAP9 GRIN2C TPSG1	1.59e-05	38	91	4	CID000003614
Drug	GDP-Man	ANO4 PANK2 LEMD3 FUT6 PIGZ SLC17A6	2.11e-05	140	91	6	CID000000732
Disease	Miller-McKusick-Malvaux-Syndrome (3M Syndrome)	CCDC8 CUL7	8.59e-06	2	87	2	C1848862
Disease	Three M Syndrome 1	CCDC8 CUL7	8.59e-06	2	87	2	C2678312
Disease	cataract 46 juvenile-onset (implicated_via_orthology)	LEMD3 LEMD2	8.59e-06	2	87	2	DOID:0110243 (implicated_via_orthology)
Disease	3-M syndrome (is_implicated_in)	CCDC8 CUL7	2.57e-05	3	87	2	DOID:0060241 (is_implicated_in)
Disease	3-M syndrome	CCDC8 CUL7	2.57e-05	3	87	2	cv:C1848862
Disease	ventral diencephalon volume measurement	KANSL1 PTPRCAP	1.79e-04	7	87	2	EFO_0010337
Disease	tryptase beta-2 measurement	TPSD1 TPSG1	3.05e-04	9	87	2	EFO_0008306
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	LEMD3 LEMD2	5.56e-04	12	87	2	DOID:11726 (implicated_via_orthology)
Disease	Tinnitus	SPATA31A1 PKHD1 TMEM131 SDK1	6.03e-04	130	87	4	HP_0000360
Disease	idiopathic pulmonary fibrosis	IVD KANSL1 FUT6	6.46e-04	57	87	3	EFO_0000768
Disease	acute graft vs. host disease, donor genotype effect measurement	TMEM131 SDK1	8.80e-04	15	87	2	EFO_0004599, EFO_0007892
Disease	nose morphology measurement, mouth morphology measurement	ANO4 KCNQ1	1.74e-03	21	87	2	EFO_0007843, EFO_0007955
Disease	multisite chronic pain	LEMD2 FAM120AOS SDK1	2.82e-03	95	87	3	EFO_0010100

Protein segments in the cluster

Peptide	Gene	Start	Entry
WRRAARMPRAGSSAW	nan	11	Q6ZRU5
NLKPVWASRGCPRAW	ALDH16A1	761	Q8IZ83
MSKRSWWAGSRKPPR	GPR17	1	Q13304
PALLWGVGAARRWRS	ABCB10	56	Q9NRK6
ALLSRPWTGAGLRWK	ALDH4A1	11	P30038
KAREPSVGGRWRVSW	AQP8	16	O94778
WRRPLASRAKDIGIW	ANO4	756	Q32M45
GEPKRRSRSNISGWW	DLGAP4	191	Q9Y2H0
ASWDTWRNKAVVPPR	IQCN	896	Q9H0B3
RKPHSWWGARRPAGP	LEMD3	191	Q9Y2U8
RTARPKPRVSPDWWE	CFAP99	601	D6REC4
WWSRSLTGARWPRPL	POLDIP2	16	Q9Y2S7
GQAPRWSRWRVPGRL	MMP24	21	Q9Y5R2
WAWGRLPKVARAERP	LPIN3	246	Q9BQK8
SPPRAERKRWGWGRL	KCNQ1	6	P51787
GLAARRWWAASPAPA	LEMD2	156	Q8NC56
RWWAASPAPARLPSS	LEMD2	161	Q8NC56
AAARWPGWRSLQRPA	ATXN2	21	Q99700
WALPRLSSAWPGTLR	HSPB8	51	Q9UJY1
GPLPWLWAARTRVAR	IL17RE	536	Q8NFR9
DSARKGSWEPWSRPV	CCDC9B	211	Q6ZUT6
WLSRARATPTKPQVW	PCSK4	736	Q6UW60
PLGRRRWLSRNTWGP	FAM157A	251	C9JC47
WVRARAVRRPPALGW	PEX6	91	Q13608
ASRVLGRALPAWRWR	CUL7	451	Q14999
GWRPRRTILFASWDA	FOLH1B	101	Q9HBA9
RWERAPLASQGWKSR	DDX28	86	Q9NUL7
RWLWTTSVPPQRRGS	KANSL1	931	Q7Z3B3
WPSATSWERRRLSPG	HRES1	81	P13985
KAWAVARGRWPPSSR	IRF7	61	Q92985
LGWRVASWRLRPPLA	IVD	11	P26440
RGTQERTWKPPRWTR	ARHGAP12	286	Q8IWW6
RTWKPPRWTRDASIS	ARHGAP12	291	Q8IWW6
WQEPRPEPNSRSKRW	PTOV1	266	Q86YD1
WWGLSREPRGSRPLS	POM121C	66	A8CG34
NPRALAQGPWWARKR	PLCD1	616	P51178
SARGRWPWQASLRLR	PRSS41	61	Q7RTY9
PSPASSDWLPARWRN	PANK2	71	Q9BZ23
WWGLSREPRGSRPLS	POM121	66	Q96HA1
PGARVIRGLDWKWRD	HECTD1	1276	Q9ULT8
SLPRRRNPGWVSWSD	C5orf60	256	A6NFR6
GSRWPPAIRQATRWK	C19orf71	36	A6NCJ1
STRWGSALWKDRPIR	C19orf71	131	A6NCJ1
AQRRRRSSVFPWPWG	CPAMD8	666	Q8IZJ3
WGSRRRWVTPAGRPD	JMJD4	111	Q9H9V9
WLFLDWKTPERGGRR	AWAT1	51	Q58HT5
WKTPERGGRRSAWVR	AWAT1	56	Q58HT5
KVAGSPGWVRTRWAL	SLC3A2	171	P08195
PSRLRPKRSWGTWEE	C16orf90	151	A8MZG2
WGCAAAGKPRPTVRW	CNTN2	346	Q02246
PRSPRRQGQRWIWFS	FUT6	121	P51993
VARSRSPKLWPSVRW	C2orf81	456	A6NN90
TIWHLRSTPPRRKQW	H1-9P	6	P60008
RLWPRASAVGERLWS	HEXB	501	P07686
PTWRPLGSWREQLAR	B9D2	111	Q9BPU9
SPRRWRPKINWASFR	CCDC8	261	Q9H0W5
RPQWHGKSRSGWRRC	CROCCP3	231	Q8IVE0
RRAAKLGPGRRGWWA	SDK1	71	Q7Z5N4
RAWFSWPRASPASGA	SCNN1D	731	P51172
PLAPWHKRGGRRAAW	P2RY6	131	Q15077
WSLRRDPRGAPAWAT	GRIN3B	371	O60391
WWGLSRAFTVKPEGR	RUSF1	41	Q96GQ5
PRYRWQRSKWGRTCP	AK9	326	Q5TCS8
RSKWPWQVSLRVRGP	TPSD1	46	Q9BZJ3
AGAWPWQASLRLRRV	TPSG1	46	Q9NRR2
LPGWKADTTGARRWE	ADSS1	406	Q8N142
VVWSLAGWRPARGRP	LTB4R2	41	Q9NPC1
GRTRRLLWASPPGRW	PTPRCAP	76	Q14761
AWALRDTPIPRWKLS	NBEAL2	1816	Q6ZNJ1
AWKQFQRAPRGIPSW	SPATA31A7	891	Q8IWB4
RPRTPNRDSWRRAWA	FAM120AOS	31	Q5T036
LKVWDGTRTPFPSWR	POT1	181	Q9NUX5
AGPRSAGWRALRRLW	RNF227	141	A6NIN4
REPWWGSRAALPLTK	SIM1	486	P81133
PWRRLFRKPAVWAAV	SLC17A9	231	Q9BYT1
RRWSRTHSWFPERLP	PKHD1	1926	P08F94
AAPLRAWAWRSSDPP	RUSC1-AS1	206	Q66K80
WARLPKNRHSPSWSP	NINL	576	Q9Y2I6
RGKWWRPSGPDFRCI	SOST	121	Q9BQB4
GVASRWRRRRPWLDP	RXRB	31	P28702
WSRVSGIPSRRHWPV	CLN5	41	O75503
PGSLRRDTERIWSPW	CILP	141	O75339
GPRWRRRWFVLKGHT	CNKSR1	421	Q969H4
SRKVRDLWWQGIPPS	TBC1D14	391	Q9P2M4
AWKQFQRAPRGIPSW	SPATA31A3	891	Q5VYP0
WRLPPRWSQLGTSQR	SENP3	96	Q9H4L4
IWSKWAPPLERSRLA	SLC17A6	201	Q9P2U8
PEWSLATGWRFKKRP	TIMM50	161	Q3ZCQ8
AWKQFQRAPRGIPSW	SPATA31A1	891	Q5TZJ5
AWKQFQRAPRGIPSW	SPATA31A5	891	Q5VU36
WKRPFGRPSAKWSRR	PLEKHD1	36	A6NEE1
AWGSSRGWLAPREAR	TMC4	11	Q7Z404
YNPWRIWSPTIGRRS	TMEM131	1856	Q92545
WWLARRLEAPSTSRP	ARHGAP9	61	Q9BRR9
RAARPKDLPRDWLWG	WNT5A	166	P41221
TRKEPAPGPRWRSWL	PIGZ	201	Q86VD9
PPWESKNSTAVWRGR	POGLUT2	296	Q6UW63
WSEAAPKPFSRWRNL	SLC28A1	51	O00337
WRAIRPIPIQGSWAK	ZNF229	176	Q9UJW7
GRSLPRRRNPGWVSW	nan	81	Q8NA96
RSKNWRLSVRCGGWP	SP140	636	Q13342
WSEWFRRAPPESRVS	TST	276	Q16762
VSRVSRRPAWEARWP	GRIN2C	991	Q14957