Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of tooth enamel	AMELX AMELY	5.26e-05	6	38	2	GO:0030345
GeneOntologyMolecularFunction	hydroxyapatite binding	AMELX AMELY	9.80e-05	8	38	2	GO:0046848
GeneOntologyMolecularFunction	sodium ion binding	AMELX AMELY	3.16e-04	14	38	2	GO:0031402
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring compression resistance	AMELX AMELY	8.70e-04	23	38	2	GO:0030021
GeneOntologyMolecularFunction	alkali metal ion binding	AMELX AMELY	1.11e-03	26	38	2	GO:0031420
GeneOntologyBiologicalProcess	animal organ morphogenesis	AMELX AMELY SETD2 FAT1 IRX3 HOXC9 SOX8 NFKB1 NECTIN1 SEC24B NR5A2	1.18e-05	1269	38	11	GO:0009887
GeneOntologyBiologicalProcess	enamel mineralization	AMELX AMELY NECTIN1	1.29e-05	25	38	3	GO:0070166
GeneOntologyBiologicalProcess	amelogenesis	AMELX AMELY NECTIN1	2.76e-05	32	38	3	GO:0097186
GeneOntologyBiologicalProcess	tooth mineralization	AMELX AMELY NECTIN1	4.65e-05	38	38	3	GO:0034505
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	AMELX AMELY SETD2 IRX3 EYA2 SOX8 FN1 LOXL2 SOX30 NECTIN1 SEC24B	5.02e-05	1483	38	11	GO:0048646
GeneOntologyBiologicalProcess	autonomic nervous system development	SOX8 FN1 INSM1	1.07e-04	50	38	3	GO:0048483
GeneOntologyBiologicalProcess	mesenchymal cell differentiation	AMELX FAM83D SOX8 FN1 LOXL2	2.00e-04	296	38	5	GO:0048762
GeneOntologyBiologicalProcess	embryonic epithelial tube formation	SETD2 IRX3 SOX8 SEC24B	2.05e-04	159	38	4	GO:0001838
GeneOntologyBiologicalProcess	epithelial tube formation	SETD2 IRX3 SOX8 SEC24B	2.82e-04	173	38	4	GO:0072175
GeneOntologyBiologicalProcess	embryonic morphogenesis	SETD2 IRX3 HOXC9 EYA2 SOX8 FN1 SEC24B	2.84e-04	713	38	7	GO:0048598
GeneOntologyBiologicalProcess	tube formation	SETD2 IRX3 SOX8 SEC24B	3.80e-04	187	38	4	GO:0035148
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	SETD2 IRX3 SOX8 SEC24B	4.03e-04	190	38	4	GO:0016331
GeneOntologyBiologicalProcess	pre-miRNA processing	BCDIN3D DROSHA	4.42e-04	17	38	2	GO:0031054
GeneOntologyCellularComponent	basement membrane	AMELX AMELY FN1 LOXL2	6.99e-05	122	38	4	GO:0005604
MousePheno	abnormal enamel rod pattern	AMELX AMELY NECTIN1	7.98e-07	8	35	3	MP:0002649
MousePheno	abnormal tooth wear	AMELX AMELY NECTIN1	1.70e-06	10	35	3	MP:0030458
MousePheno	brittle teeth	AMELX AMELY NECTIN1	3.11e-06	12	35	3	MP:0000126
MousePheno	abnormal enamel mineralization	AMELX AMELY NECTIN1	4.04e-06	13	35	3	MP:0030450
MousePheno	short incisors	AMELX AMELY NECTIN1	5.14e-06	14	35	3	MP:0004830
MousePheno	short Tomes' process	AMELX AMELY	6.09e-06	2	35	2	MP:0030513
MousePheno	abnormal incisor color	AMELX AMELY NECTIN1	7.87e-06	16	35	3	MP:0010096
MousePheno	abnormal Tomes' process morphology	AMELX AMELY	1.82e-05	3	35	2	MP:0030512
MousePheno	small incisors	AMELX AMELY NECTIN1	2.14e-05	22	35	3	MP:0030079
MousePheno	abnormal molar crown morphology	AMELX AMELY NECTIN1	2.14e-05	22	35	3	MP:0003932
MousePheno	abnormal ameloblast morphology	AMELX AMELY NECTIN1	2.14e-05	22	35	3	MP:0002650
MousePheno	abnormal lower incisor morphology	AMELX AMELY NECTIN1	3.18e-05	25	35	3	MP:0030136
MousePheno	abnormal tooth mineralization	AMELX AMELY NECTIN1	3.59e-05	26	35	3	MP:0002817
MousePheno	microdontia	AMELX AMELY NECTIN1	3.59e-05	26	35	3	MP:0030088
MousePheno	large mandible	AMELX AMELY	3.64e-05	4	35	2	MP:0030050
MousePheno	abnormal enamel development	AMELX AMELY NECTIN1	4.04e-05	27	35	3	MP:0030544
MousePheno	abnormal head morphology	TRAF3IP2 AMELX AMELY SETD2 FAT1 IRX3 FN1 LYST NECTIN1 INSM1 SEC24B	5.74e-05	1120	35	11	MP:0000432
MousePheno	enamel pits	AMELX AMELY	6.06e-05	5	35	2	MP:0030460
MousePheno	short upper incisors	AMELX AMELY	9.08e-05	6	35	2	MP:0030090
MousePheno	small upper incisors	AMELX AMELY	1.27e-04	7	35	2	MP:0030081
MousePheno	short lower incisors	AMELX AMELY	1.27e-04	7	35	2	MP:0030089
MousePheno	abnormal tooth color	AMELX AMELY NECTIN1	1.33e-04	40	35	3	MP:0013129
MousePheno	abnormal enamel morphology	AMELX AMELY NECTIN1	1.90e-04	45	35	3	MP:0002576
MousePheno	abnormal molar morphology	AMELX AMELY NECTIN1	2.76e-04	51	35	3	MP:0002689
MousePheno	small lower incisors	AMELX AMELY	3.30e-04	11	35	2	MP:0030080
MousePheno	reduced enamel thickness	AMELX AMELY	3.96e-04	12	35	2	MP:0002577
MousePheno	increased lung tissue damping	AMELX AMELY	4.67e-04	13	35	2	MP:0011047
MousePheno	abnormal tooth hard tissue morphology	AMELX AMELY NECTIN1	5.15e-04	63	35	3	MP:0003930
MousePheno	abnormal lung tissue damping	AMELX AMELY	7.15e-04	16	35	2	MP:0011046
MousePheno	abnormal molar cusp morphology	AMELX AMELY	7.15e-04	16	35	2	MP:0030457
MousePheno	premature hair loss	LYST POLG	8.09e-04	17	35	2	MP:0005114
MousePheno	large intestinal inflammation	BPI GFUS NFKB1 NR5A2	8.98e-04	174	35	4	MP:0003304
MousePheno	abnormal podocyte slit junction morphology	KIRREL1 FAT1	9.09e-04	18	35	2	MP:0008062
MousePheno	abnormal upper incisor morphology	AMELX AMELY	1.01e-03	19	35	2	MP:0030137
MousePheno	absent teeth	AMELX AMELY	1.12e-03	20	35	2	MP:0030610
MousePheno	failure of eyelid fusion	NECTIN1 SEC24B	1.12e-03	20	35	2	MP:0009264
MousePheno	abnormal lymph node morphology	TRAF3IP2 AMELX AMELY EYA2 BPI NFKB1 SEC24B	1.31e-03	683	35	7	MP:0002339
MousePheno	abnormal anterior eye segment morphology	CAPN12 KIRREL1 FAT1 IGSF9B IRX3 LYST NFKB1 NECTIN1 FAM83B	1.35e-03	1117	35	9	MP:0005193
MousePheno	intestinal inflammation	BPI GFUS NFKB1 NR5A2	1.37e-03	195	35	4	MP:0001858
MousePheno	enlarged lymph nodes	TRAF3IP2 AMELX AMELY EYA2 NFKB1 SEC24B	1.46e-03	507	35	6	MP:0000702
MousePheno	craniofacial phenotype	TRAF3IP2 AMELX AMELY SETD2 FAT1 IRX3 LYST NECTIN1 INSM1 SEC24B	1.49e-03	1372	35	10	MP:0005382
MousePheno	abnormal craniofacial morphology	TRAF3IP2 AMELX AMELY SETD2 FAT1 IRX3 LYST NECTIN1 INSM1 SEC24B	1.49e-03	1372	35	10	MP:0000428
MousePheno	increased susceptibility to age-related hearing loss	POLG NFKB1	1.49e-03	23	35	2	MP:0004748
Domain	Amelogenin	AMELX AMELY	4.03e-06	2	38	2	IPR004116
Domain	Amelogenin	AMELX AMELY	4.03e-06	2	38	2	SM00818
Domain	Amelogenin	AMELX AMELY	4.03e-06	2	38	2	PF02948
Domain	IGc2	KIRREL1 MALT1 IGSF9B ROR1 NECTIN1	1.08e-04	235	38	5	SM00408
Domain	Ig_sub2	KIRREL1 MALT1 IGSF9B ROR1 NECTIN1	1.08e-04	235	38	5	IPR003598
Domain	DUF1669	FAM83D FAM83B	1.12e-04	8	38	2	IPR012461
Domain	DUF1669	FAM83D FAM83B	1.12e-04	8	38	2	PF07894
Domain	-	KIRREL1 MALT1 IGSF9B FN1 NFKB1 ROR1 NECTIN1	3.33e-04	663	38	7	2.60.40.10
Domain	Ig-like_fold	KIRREL1 MALT1 IGSF9B FN1 NFKB1 ROR1 NECTIN1	4.86e-04	706	38	7	IPR013783
Domain	IG	KIRREL1 MALT1 IGSF9B ROR1 NECTIN1	1.55e-03	421	38	5	SM00409
Domain	Ig_sub	KIRREL1 MALT1 IGSF9B ROR1 NECTIN1	1.55e-03	421	38	5	IPR003599
Domain	Kringle-like	FN1 ROR1	1.92e-03	32	38	2	IPR013806
Domain	Death_domain	MALT1 NFKB1	2.71e-03	38	38	2	IPR000488
Domain	DEATH_DOMAIN	MALT1 NFKB1	2.71e-03	38	38	2	PS50017
Domain	IG_LIKE	KIRREL1 MALT1 IGSF9B ROR1 NECTIN1	3.02e-03	491	38	5	PS50835
Domain	C2-set_2	KIRREL1 NECTIN1	3.14e-03	41	38	2	PF08205
Domain	CD80_C2-set	KIRREL1 NECTIN1	3.14e-03	41	38	2	IPR013162
Domain	Ig-like_dom	KIRREL1 MALT1 IGSF9B ROR1 NECTIN1	3.35e-03	503	38	5	IPR007110
Domain	HMG_box	SOX8 SOX30	5.20e-03	53	38	2	PF00505
Domain	HMG_BOX_2	SOX8 SOX30	5.40e-03	54	38	2	PS50118
Domain	HMG	SOX8 SOX30	5.40e-03	54	38	2	SM00398
Domain	-	SOX8 SOX30	5.59e-03	55	38	2	1.10.30.10
Domain	V-set	KIRREL1 IGSF9B NECTIN1	6.16e-03	184	38	3	PF07686
Domain	Ig_I-set	KIRREL1 IGSF9B ROR1	6.73e-03	190	38	3	IPR013098
Domain	I-set	KIRREL1 IGSF9B ROR1	6.73e-03	190	38	3	PF07679
Domain	Ig_V-set	KIRREL1 IGSF9B NECTIN1	7.64e-03	199	38	3	IPR013106
Domain	HMG_box_dom	SOX8 SOX30	7.73e-03	65	38	2	IPR009071
Domain	Ig_2	MALT1 IGSF9B	9.67e-03	73	38	2	PF13895
Domain	IGv	IGSF9B NECTIN1	1.02e-02	75	38	2	SM00406
Pathway	REACTOME_CLEC7A_INFLAMMASOME_PATHWAY	MALT1 NFKB1	7.45e-05	6	32	2	M27542
Pubmed	TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding.	AMELX AMELY FN1	1.20e-08	5	38	3	17699513
Pubmed	The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice.	AMELX AMELY NECTIN1	1.01e-07	9	38	3	18703497
Pubmed	Amelogenin-deficient mice display an amelogenesis imperfecta phenotype.	AMELX AMELY	1.16e-06	2	38	2	11406633
Pubmed	MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.	MALT1 NFKB1	1.16e-06	2	38	2	25996250
Pubmed	The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice.	AMELX AMELY	1.16e-06	2	38	2	12851394
Pubmed	Amelogenin, the major protein of tooth enamel: a new phylogenetic marker for ordinal mammal relationships.	AMELX AMELY	1.16e-06	2	38	2	18346915
Pubmed	Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6.	AMELX AMELY	1.16e-06	2	38	2	29337060
Pubmed	Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence.	AMELX AMELY	1.16e-06	2	38	2	8297387
Pubmed	Thermal denaturation of a recombinant mouse amelogenin: circular dichroism and differential scanning calorimetric studies.	AMELX AMELY	1.16e-06	2	38	2	16284958
Pubmed	Human and mouse amelogenin gene loci are on the sex chromosomes.	AMELX AMELY	1.16e-06	2	38	2	2737677
Pubmed	Inhibition of nuclear factor-kappaB by hyaluronan in rheumatoid chondrocytes stimulated with COOH-terminal heparin-binding fibronectin fragment.	FN1 NFKB1	1.16e-06	2	38	2	17929131
Pubmed	A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride.	AMELX AMELY	1.16e-06	2	38	2	19086270
Pubmed	Molecular structure of the mouse amelogenin genomic DNA.	AMELX AMELY	1.16e-06	2	38	2	8988368
Pubmed	Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.	AMELX AMELY	1.16e-06	2	38	2	21825148
Pubmed	Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture.	AMELX AMELY	1.16e-06	2	38	2	12489164
Pubmed	Amelogenin: a potential regulator of cementum-associated genes.	AMELX AMELY	1.16e-06	2	38	2	14653387
Pubmed	A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo.	AMELX AMELY	1.16e-06	2	38	2	7489712
Pubmed	The leucine-rich amelogenin protein (LRAP) is primarily monomeric and unstructured in physiological solution.	AMELX AMELY	1.16e-06	2	38	2	25449314
Pubmed	High-yield recombinant bacterial expression of 13 C-, 15 N-labeled, serine-16 phosphorylated, murine amelogenin using a modified third generation genetic code expansion protocol.	AMELX AMELY	1.16e-06	2	38	2	36585836
Pubmed	Isolation and characterization of a mouse amelogenin expressed in Escherichia coli.	AMELX AMELY	1.16e-06	2	38	2	8062146
Pubmed	Transgenic mice that express normal and mutated amelogenins.	AMELX AMELY	1.16e-06	2	38	2	17384027
Pubmed	Alternative splicing of the mouse amelogenin primary RNA transcript.	AMELX AMELY	1.16e-06	2	38	2	7820782
Pubmed	Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin.	AMELX AMELY	1.16e-06	2	38	2	26709694
Pubmed	Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta.	AMELX AMELY	1.16e-06	2	38	2	7782077
Pubmed	Comparison of body weight and gene expression in amelogenin null and wild-type mice.	AMELX AMELY	1.16e-06	2	38	2	16674684
Pubmed	Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6 Amelx-/- mice and Amelx+/- lyonization.	AMELX AMELY	1.16e-06	2	38	2	27896287
Pubmed	Amelogenin-collagen interactions regulate calcium phosphate mineralization in vitro.	AMELX AMELY	1.16e-06	2	38	2	20404336
Pubmed	Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ.	AMELX AMELY	1.16e-06	2	38	2	1444889
Pubmed	Scavenger Receptor Cysteine-Rich domains of Lysyl Oxidase-Like2 regulate endothelial ECM and angiogenesis through non-catalytic scaffolding mechanisms.	FN1 LOXL2	1.16e-06	2	38	2	31759052
Pubmed	Identification of the functional activity of the [A-4] amelogenin gene splice product in newborn mouse ameloblasts.	AMELX AMELY	1.16e-06	2	38	2	18394981
Pubmed	A solution NMR investigation into the impaired self-assembly properties of two murine amelogenins containing the point mutations T21→I or P41→T.	AMELX AMELY	1.16e-06	2	38	2	23896516
Pubmed	Stage-Specific Role of Amelx Activation in Stepwise Ameloblast Induction from Mouse Induced Pluripotent Stem Cells.	AMELX AMELY	1.16e-06	2	38	2	34281250
Pubmed	The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates.	AMELX AMELY	1.16e-06	2	38	2	1427830
Pubmed	Transgene animal model for protein expression and accumulation into forming enamel.	AMELX AMELY	1.16e-06	2	38	2	11063035
Pubmed	Regulation of amelogenin gene expression.	AMELX AMELY	1.16e-06	2	38	2	10200911
Pubmed	Truncated amelogenin and LRAP transgenes improve Amelx null mouse enamel.	AMELX AMELY	1.16e-06	2	38	2	26607574
Pubmed	A human X-Y homologous region encodes "amelogenin".	AMELX AMELY	1.16e-06	2	38	2	2004775
Pubmed	Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice.	AMELX AMELY	1.16e-06	2	38	2	35219810
Pubmed	Of mice and men: anatomy of the amelogenin gene.	AMELX AMELY	1.16e-06	2	38	2	2689082
Pubmed	Altering biomineralization by protein design.	AMELX AMELY	1.16e-06	2	38	2	16707492
Pubmed	Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure.	AMELX AMELY	1.16e-06	2	38	2	21984897
Pubmed	The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.	TRAF3IP2 IGF2BP2	1.16e-06	2	38	2	34215679
Pubmed	The murine amelogenin promoter: developmentally regulated expression in transgenic animals.	AMELX AMELY	1.16e-06	2	38	2	9084642
Pubmed	Cryogenic transmission electron microscopy study of amelogenin self-assembly at different pH.	AMELX AMELY	1.16e-06	2	38	2	21597263
Pubmed	Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.	AMELX AMELY	1.16e-06	2	38	2	23948316
Pubmed	Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development.	AMELX AMELY	1.16e-06	2	38	2	8392462
Pubmed	Amelogenins as potential buffers during secretory-stage amelogenesis.	AMELX AMELY	1.16e-06	2	38	2	25535204
Pubmed	An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.	AMELX AMELY	1.16e-06	2	38	2	20923441
Pubmed	The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC.	LOXL2 NFKB1	1.16e-06	2	38	2	37737908
Pubmed	Model system for evaluation of alternative splicing: exon skipping.	AMELX AMELY	1.16e-06	2	38	2	11879574
Pubmed	Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.	AMELX AMELY	1.16e-06	2	38	2	9878259
Pubmed	Analysis of self-assembly and apatite binding properties of amelogenin proteins lacking the hydrophilic C-terminal.	AMELX AMELY	1.16e-06	2	38	2	11852235
Pubmed	Amelogenin genes and sexual dimorphism of teeth in humans and mice.	AMELX AMELY	1.16e-06	2	38	2	1463023
Pubmed	Translocation of enamel proteins from inner enamel epithelia to odontoblasts during mouse tooth development.	AMELX AMELY	1.16e-06	2	38	2	8179220
Pubmed	Phosphorylation and ionic strength alter the LRAP-HAP interface in the N-terminus.	AMELX AMELY	1.16e-06	2	38	2	23477367
Pubmed	Protein interactions during assembly of the enamel organic extracellular matrix.	AMELX AMELY	1.16e-06	2	38	2	9041053
Pubmed	Highly acidic pH facilitates enamel protein self-assembly, apatite crystal growth and enamel protein interactions in the early enamel matrix.	AMELX AMELY	1.16e-06	2	38	2	36569763
Pubmed	Exon4 amelogenin transcripts in enamel biomineralization.	AMELX AMELY	1.16e-06	2	38	2	25792521
Pubmed	The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype.	AMELX AMELY	1.16e-06	2	38	2	18701811
Pubmed	Expression of amelogenin in odontoblasts.	AMELX AMELY	1.16e-06	2	38	2	12667550
Pubmed	Spatial- and temporal-restricted pattern for amelogenin gene expression during mouse molar tooth organogenesis.	AMELX AMELY	1.16e-06	2	38	2	3253061
Pubmed	Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway.	AMELX AMELY	1.16e-06	2	38	2	19462488
Pubmed	Isolation and characterization of a pseudoautosomal region-specific genetic marker in C57BL/6 mice using genomic representational difference analysis.	AMELX AMELY	1.16e-06	2	38	2	8618899
Pubmed	A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta.	AMELX AMELY	1.16e-06	2	38	2	20067920
Pubmed	Novel LRAP-binding partner revealing the plasminogen activation system as a regulator of cementoblast differentiation and mineral nodule formation in vitro.	AMELX AMELY	1.16e-06	2	38	2	31621902
Pubmed	Reuptake of extracellular amelogenin by dental epithelial cells results in increased levels of amelogenin mRNA through enhanced mRNA stabilization.	AMELX AMELY	1.16e-06	2	38	2	16293627
Pubmed	Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.	AMELX AMELY	1.16e-06	2	38	2	23747796
Pubmed	Evolution in tooth developmental biology: of morphology and molecules.	AMELX AMELY	1.16e-06	2	38	2	8769659
Pubmed	Amelogenin promotes odontoblast-like MDPC-23 cell differentiation via activation of ERK1/2 and p38 MAPK.	AMELX AMELY	1.16e-06	2	38	2	21547453
Pubmed	Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.	AMELX AMELY	1.16e-06	2	38	2	1445358
Pubmed	Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1).	AMELX AMELY	1.16e-06	2	38	2	11877393
Pubmed	Partial rescue of the amelogenin null dental enamel phenotype.	AMELX AMELY	1.16e-06	2	38	2	18390542
Pubmed	Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T point mutations.	AMELX AMELY	1.16e-06	2	38	2	21540557
Pubmed	The energetic basis for hydroxyapatite mineralization by amelogenin variants provides insights into the origin of amelogenesis imperfecta.	AMELX AMELY	1.16e-06	2	38	2	31239344
Pubmed	Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis.	AMELX AMELY	1.16e-06	2	38	2	19097165
Pubmed	A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich Amelogenin Protein).	AMELX AMELY	1.16e-06	2	38	2	20304108
Pubmed	Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.	AMELX AMELY	1.16e-06	2	38	2	24362885
Pubmed	Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro.	AMELX AMELY	1.16e-06	2	38	2	15647828
Pubmed	DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein.	AMELX AMELY	1.16e-06	2	38	2	4015654
Pubmed	Weaker dental enamel explains dental decay.	AMELX AMELY	1.16e-06	2	38	2	25885796
Pubmed	Structural variation of the pseudoautosomal region between and within inbred mouse strains.	AMELX AMELY	1.16e-06	2	38	2	8552598
Pubmed	The amelogenin C-terminus is required for enamel development.	AMELX AMELY	1.16e-06	2	38	2	20042744
Pubmed	Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice.	AMELX AMELY	1.16e-06	2	38	2	34780561
Pubmed	Comparison of upstream regions of X- and Y-chromosomal amelogenin genes.	AMELX AMELY	1.16e-06	2	38	2	9714776
Pubmed	Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor.	AMELX AMELY	1.16e-06	2	38	2	31919099
Pubmed	The small bovine amelogenin LRAP fails to rescue the amelogenin null phenotype.	AMELX AMELY	1.16e-06	2	38	2	12958690
Pubmed	[Types and frequencies of variants in Amelogenin gene in Chinese population].	AMELX AMELY	1.16e-06	2	38	2	18067069
Pubmed	The circadian clock modulates enamel development.	AMELX AMELY	1.16e-06	2	38	2	22653892
Pubmed	Cloning, characterization, and heterologous expression of exon-4-containing amelogenin mRNAs.	AMELX AMELY	1.16e-06	2	38	2	9062557
Pubmed	Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution.	AMELX AMELY	1.16e-06	2	38	2	15972588
Pubmed	Origin, splicing, and expression of rodent amelogenin exon 8.	AMELX AMELY	3.48e-06	3	38	2	16998127
Pubmed	Early determination and permissive expression of amelogenin transcription during mouse mandibular first molar development.	AMELX AMELY	3.48e-06	3	38	2	8026631
Pubmed	Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin.	AMELX AMELY	3.48e-06	3	38	2	18515207
Pubmed	HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB.	IGF2BP2 NFKB1	3.48e-06	3	38	2	17426251
Pubmed	Synergistic roles of amelogenin and ameloblastin.	AMELX AMELY	3.48e-06	3	38	2	19407150
Pubmed	A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel.	AMELX AMELY	3.48e-06	3	38	2	16674657
Pubmed	Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system.	AMELX AMELY	3.48e-06	3	38	2	16674683
Pubmed	Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells.	AMELX AMELY	3.48e-06	3	38	2	16674693
Pubmed	Ultrastructure of early amelogenesis in wild-type, Amelx-/-, and Enam-/- mice: enamel ribbon initiation on dentin mineral and ribbon orientation by ameloblasts.	AMELX AMELY	3.48e-06	3	38	2	27896288
Pubmed	Biglycan overexpression on tooth enamel formation in transgenic mice.	AMELX AMELY	3.48e-06	3	38	2	18727043
GeneFamily	Immunoglobulin like domain containing	KIRREL1 MALT1 IGSF9B NECTIN1	1.57e-04	193	26	4	594
GeneFamily	SRY-boxes	SOX8 SOX30	3.35e-04	19	26	2	757
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	KIRREL1 NECTIN1	1.50e-03	40	26	2	592
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	KIRREL1 IGSF9B ROR1	1.55e-03	161	26	3	593
Coexpression	GSE32901_TH1_VS_TH17_NEG_CD4_TCELL_UP	MALT1 SETD2 IGSF9B TMEM255A	3.86e-05	131	38	4	M8922
Coexpression	ZHOU_TNF_SIGNALING_4HR	KEL DROSHA NFKB1	5.26e-05	50	38	3	M1520
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	FAM83D SHISA2 FAT1 IGF2BP2 EYA2 SOX8 DROSHA LOXL2	8.20e-05	1009	38	8	M157
Coexpression	GSE21360_NAIVE_VS_SECONDARY_MEMORY_CD8_TCELL_UP	TRAF3IP2 MALT1 IGF2BP2 NFKB1	1.41e-04	183	38	4	M7631
Coexpression	DOUGLAS_BMI1_TARGETS_UP	FAM83D HOXC9 EYA2 FN1 LOXL2 SEC24B	1.47e-04	563	38	6	M15103
Coexpression	GSE18281_CORTEX_VS_MEDULLA_THYMUS_UP	AMELY LYST TMEM255A INSM1	1.73e-04	193	38	4	M7242
Coexpression	PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2	IGF2BP2 LYST LOXL2	1.77e-04	75	38	3	M2414
Coexpression	BRUECKNER_TARGETS_OF_MIRLET7A3_DN	FAM83D FN1 LOXL2	1.84e-04	76	38	3	M11825
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_12H_BMDC_DN	TRAF3IP2 IRX3 NFKB1 NR5A2	1.91e-04	198	38	4	M3792
Coexpression	GSE3982_MAST_CELL_VS_TH1_UP	FAT1 BPI LYST DROSHA	1.94e-04	199	38	4	M5453
Coexpression	GSE24210_IL35_TREATED_VS_UNTREATED_TCONV_CD4_TCELL_UP	PRR32 TBC1D25 LOXL2 SOX30	1.94e-04	199	38	4	M7845
Coexpression	GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN	SHISA2 ZNF608 LYST NFKB1	1.98e-04	200	38	4	M6949
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 SHISA2 FAT1 IRX3 HOXC9 FN1	1.42e-08	193	38	6	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	COVID-19-Myeloid-Migratory_DC\|COVID-19 / Condition, Lineage and Cell class	MALT1 ZNF608 LOXL2 NFKB1 ROR1 INSM1	1.60e-08	197	38	6	b6d6cdae33753c1e38394f1f879e00b87f9c0496
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A ROR1	5.14e-07	186	38	5	77592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FAT1 IRX3 HOXC9 FN1 TMEM255A	5.42e-07	188	38	5	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL1 FAT1 IGSF9B EYA2 ZNF608	5.42e-07	188	38	5	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL1 FAT1 IGSF9B EYA2 ZNF608	5.42e-07	188	38	5	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PRR32 FAT1 IRX3 HOXC9 FN1	5.42e-07	188	38	5	ed92cddf47defea2f904d36c7ae05ffa323349a9
ToppCell	Mild-Myeloid-mDC-\|Mild / Condition, Lineage, Cell class and cell subclass	ZNF608 LOXL2 NFKB1 ROR1 INSM1	6.01e-07	192	38	5	8520b3fdf4508ac66f7918da613abc928ab5832a
ToppCell	Mild-Myeloid-mDC\|Mild / Condition, Lineage, Cell class and cell subclass	ZNF608 LOXL2 NFKB1 ROR1 INSM1	6.01e-07	192	38	5	da3952bd5c96242c15eb76678d0608ae2926a16e
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MALT1 ZNF608 LOXL2 NFKB1 INSM1	6.01e-07	192	38	5	2c69f3f388b69fb1c1968c923cdbab90658883dd
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MALT1 ZNF608 LOXL2 NFKB1 INSM1	6.01e-07	192	38	5	d5a7b546ebfb2e757dd9c64cb1b651f6ed0e0fc7
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MALT1 ZNF608 NFKB1 ROR1 INSM1	6.17e-07	193	38	5	a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MALT1 ZNF608 NFKB1 ROR1 INSM1	6.17e-07	193	38	5	7426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 FAT1 HOXC9 FN1 LOXL2	6.83e-07	197	38	5	2ca5ebb708935a90b12b8e98a22ae2d664ed002e
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 FAT1 HOXC9 FN1 LOXL2	6.83e-07	197	38	5	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	CAPN12 KIRREL1 FN1 LOXL2	5.13e-06	134	38	4	a3547a68012d879d4dfe80394eace70808722e43
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)\|Striatum / BrainAtlas - Mouse McCarroll V32	CAPN12 KIRREL1 FN1 LOXL2	5.13e-06	134	38	4	9458e2d0dbc18d9025b66b59f3ecc2fbc5384940
ToppCell	Severe-B_naive-5\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SHISA2 FN1 LYST NECTIN1	8.67e-06	153	38	4	44572f87d403e314050ab935d2cd676c33d9c287
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL1 FAT1 IGSF9B EYA2	9.36e-06	156	38	4	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL1 FAT1 IGSF9B EYA2	9.36e-06	156	38	4	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	Severe-B_naive-5\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SHISA2 FN1 LYST NECTIN1	9.60e-06	157	38	4	a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_C\|TCGA-Thymus / Sample_Type by Project: Shred V9	KEL IGSF9B HOXC9 INSM1	1.11e-05	163	38	4	2dac87d15051151ccf193760ddd8b82534c3f922
ToppCell	facs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHISA2 IRX3 EYA2 BPI	1.22e-05	167	38	4	78909f685ccd1321064eb0887caf9263e0e54879
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related-FDC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KEL IGSF9B SOX8 FN1	1.28e-05	169	38	4	49a54fb2ea9db5c45e107f304838c536908308bb
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	KEL EYA2 NECTIN1 FAM83B	1.34e-05	171	38	4	3965ced4be6db14265a90673502fceee425837ca
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Activated_DCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	MALT1 LOXL2 NFKB1 INSM1	1.54e-05	177	38	4	370aee11a6dc2c6f4366a13c3171f37bc5b32d65
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SHISA2 FAT1 FN1 LOXL2	1.57e-05	178	38	4	e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 LOXL2 ROR1 INSM1	1.64e-05	180	38	4	32d871738a24071b70084a7e80148a516110c78b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF608 LOXL2 ROR1 INSM1	1.64e-05	180	38	4	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL1 FAT1 IGSF9B ZNF608	1.68e-05	181	38	4	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL1 FAT1 IGSF9B ZNF608	1.68e-05	181	38	4	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 EYA2 SOX30 FAM83B	1.75e-05	183	38	4	ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCell	facs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 EYA2 SOX30 FAM83B	1.75e-05	183	38	4	f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCell	(7)_Epithelial-H_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	KEL EYA2 NECTIN1 FAM83B	1.79e-05	184	38	4	1f76b37c265b519171b767a52d48f31f0cdc4a3c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	1.79e-05	184	38	4	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MALT1 LOXL2 NFKB1 INSM1	1.83e-05	185	38	4	7e3d9f5050e71e91021245c11101e994ae41d22b
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETD2 NFKB1 HNRNPL ROR1	1.83e-05	185	38	4	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	CAPN12 MALT1 FAT1 ROR1	1.91e-05	187	38	4	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	Control-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	MALT1 LOXL2 NFKB1 INSM1	1.91e-05	187	38	4	51bfc450e78284796b02317e91830357850b5437
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 TMEM255A ROR1	1.95e-05	188	38	4	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 EYA2 LOXL2 FAM83B	1.99e-05	189	38	4	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 EYA2 LOXL2 FAM83B	1.99e-05	189	38	4	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	CAPN12 MALT1 FAT1 ROR1	1.99e-05	189	38	4	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.03e-05	190	38	4	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.03e-05	190	38	4	3b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.03e-05	190	38	4	59720dfe9de1b980807644536c919d2a02ba69dd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.03e-05	190	38	4	dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	FAT1 EYA2 NECTIN1 FAM83B	2.08e-05	191	38	4	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGF2BP2 ZNF608 LOXL2 NR5A2	2.08e-05	191	38	4	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.12e-05	192	38	4	f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.12e-05	192	38	4	690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	FAT1 EYA2 ZNF608 NECTIN1	2.12e-05	192	38	4	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	367C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	LYST LOXL2 ROR1 INSM1	2.12e-05	192	38	4	e44e37e5aeba8628556020d05e1606b28e2faa4f
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MALT1 LYST NFKB1 INSM1	2.16e-05	193	38	4	d9be4d1de863fffc2240d6fd1a2f8dfb2d2bc916
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.16e-05	193	38	4	294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.16e-05	193	38	4	3d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.21e-05	194	38	4	5d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCell	Control-Myeloid-Migratory_DC\|Control / Condition, Lineage and Cell class	MALT1 LOXL2 NFKB1 INSM1	2.21e-05	194	38	4	374076e60dcee83eb1814aa6b55b77668909f40b
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGF2BP2 ZNF608 LOXL2 NR5A2	2.21e-05	194	38	4	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL1 FAT1 ZNF608 TMEM255A	2.21e-05	194	38	4	6ac759828c41ffa974ee82842162caa959351dd1
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGF2BP2 ZNF608 LOXL2 NR5A2	2.21e-05	194	38	4	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FAT1 HOXC9 FN1 LOXL2	2.25e-05	195	38	4	30ed961151b8b1f6ce37f06c9a061519f01c2864
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	FAT1 EYA2 NECTIN1 FAM83B	2.30e-05	196	38	4	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	BAL-Mild-cDC_10\|Mild / Compartment, Disease Groups and Clusters	MALT1 ZNF608 LYST NFKB1	2.34e-05	197	38	4	c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FAT1 HOXC9 FN1 LOXL2	2.34e-05	197	38	4	63b63c6b2f842adb87bc83222ff86796bd9b58f6
ToppCell	Basal_cells\|World / lung cells shred on cell class, cell subclass, sample id	FAT1 EYA2 NECTIN1 FAM83B	2.34e-05	197	38	4	24360b660000bdfb999d58fbf4e29585a97e1785
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FAT1 HOXC9 FN1 LOXL2	2.34e-05	197	38	4	fb50903b87498b400c8e16e6a561b6d9458e5d97
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 FAT1 FN1 LOXL2	2.34e-05	197	38	4	2f72fd9a5b6d62c24a95ed2246194ea7458c0f12
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FAT1 HOXC9 FN1 LOXL2	2.39e-05	198	38	4	8602a518b5913625b1dd3cbc3c7e6efde0d5d942
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FAT1 HOXC9 FN1 LOXL2	2.39e-05	198	38	4	55d2ed345101bec4b73f1242ba8c4d73073b7e88
ToppCell	COVID-19-Myeloid-Migratory_DC\|Myeloid / Condition, Lineage and Cell class	MALT1 ZNF608 NFKB1 ROR1	2.39e-05	198	38	4	90f3b227cbc61c268d6d94bc9945a08d83d2d3d5
ToppCell	medial-2-Epithelial-Basal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	IRX3 EYA2 NECTIN1 FAM83B	2.44e-05	199	38	4	10af93596cc6d5da4cf5052707ff5f7fc347dc84
ToppCell	medial-Epithelial-Basal\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	IRX3 EYA2 NECTIN1 FAM83B	2.44e-05	199	38	4	fa7584e3cc0f8cbdd6a76c6a0faee26b0922c4ae
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 FAT1 FN1 LOXL2	2.44e-05	199	38	4	d65ee89d5c7e8ed693d58e6a6de09565840e11c5
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MALT1 LYST LOXL2 INSM1	2.44e-05	199	38	4	7b3d4c62b11268c7c1599600d8a7b331287cf21a
ToppCell	medial-Epithelial-Basal-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	IRX3 EYA2 NECTIN1 FAM83B	2.44e-05	199	38	4	fc37f8868417308fb4410684d0d1e506cec30f35
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 FAT1 FN1 LOXL2	2.44e-05	199	38	4	bf138cc692df727e087d140c014149ee5da00d9d
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIRREL1 FAT1 ZNF608 TMEM255A	2.48e-05	200	38	4	ca5401b76ab014080914bf78042d368cf318effa
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIRREL1 FAT1 ZNF608 TMEM255A	2.48e-05	200	38	4	40286010bd17cf9e34ecd5440953b072ebfae208
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 SHISA2 FAT1 FN1	2.48e-05	200	38	4	16a7c398626b6e82b394eb3ef013bda3a788659d
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IGF2BP2 FN1 ZNF608 NR5A2	2.48e-05	200	38	4	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FAT1 IRX3 EYA2 FAM83B	2.48e-05	200	38	4	8cfbde43c5e66269ad128aa5398b1517667d7d36
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	KIRREL1 FAT1 FN1 LOXL2	2.48e-05	200	38	4	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|Dendritic_cell / Region, Cell class and subclass	MALT1 SETD2 LOXL2 NFKB1	2.48e-05	200	38	4	3813fa1ee1462ba83fd8b6253070f46f0b063084
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Basal_1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FAT1 IRX3 EYA2 FAM83B	2.48e-05	200	38	4	592c7c3ded409a9957cbcdc62fcc213fa8eae598
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1--L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIRREL1 FAT1 ZNF608 TMEM255A	2.48e-05	200	38	4	70c47d3bbe67d88c5b9dff99c33a603d25fa2ab0
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIRREL1 FAT1 ZNF608 TMEM255A	2.48e-05	200	38	4	e90155498397524b812c46f2412320230b445bb6
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN12 DROSHA TMEM255A ROR1	2.48e-05	200	38	4	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FAT1 IRX3 EYA2 FAM83B	2.48e-05	200	38	4	61811380d9252f12f27b7ad4752380b52692677f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SHISA2 KEL SOX30	4.20e-05	79	38	3	03c5af851b53800eced1c74e9da374c71092bcd4
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	CAPN12 SHISA2 SOX8	2.16e-04	137	38	3	576ca865b8e8e59d23aa35cb9dafee0cf7d38e6a
ToppCell	P03-Hematopoietic-Erythroid\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KEL DROSHA FAM83B	2.50e-04	144	38	3	2ee6a834860eac7ed004f366ab4fc38c4b80c905
ToppCell	P03-Hematopoietic-Erythroid-enucleate_erythrocyte\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KEL DROSHA FAM83B	2.50e-04	144	38	3	9fa63904389f4d7163db22ea85ab721d8f6e8d99
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 SHISA2 LYST	2.76e-04	149	38	3	48fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 SHISA2 LYST	2.92e-04	152	38	3	7e686721b95c837f2b0d5116927c8ecacef055ee
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	EYA2 LOXL2 ROR1	2.98e-04	153	38	3	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	EYA2 LOXL2 ROR1	2.98e-04	153	38	3	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAM83D IGSF9B SOX8	2.98e-04	153	38	3	61fe71e32fc9c8cad875bc087aad0b0ff680bf45
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	EYA2 LOXL2 ROR1	2.98e-04	153	38	3	2513edfae62a44e51d3556675a096723194c966c
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	EYA2 LOXL2 ROR1	3.04e-04	154	38	3	65dbb60f636562eeba3dafadae9c0c7db2b27476
Disease	amelogenesis imperfecta type 1E (implicated_via_orthology)	AMELX AMELY	1.53e-06	2	37	2	DOID:0110058 (implicated_via_orthology)
Disease	monocyte count	KIRREL1 SETD2 IGF2BP2 BPI FN1 ZNF608 LYST TMEM255A NFKB1 NR5A2	3.57e-06	1320	37	10	EFO_0005091
Disease	autosomal dominant hypocalcemia (biomarker_via_orthology)	AMELX AMELY	9.17e-06	4	37	2	DOID:0090109 (biomarker_via_orthology)
Disease	hepatocellular carcinoma (is_implicated_in)	POLG NFKB1 SOX30 HNRNPL	7.72e-05	181	37	4	DOID:684 (is_implicated_in)
Disease	nephrotic syndrome (implicated_via_orthology)	KIRREL1 FAT1	4.15e-04	24	37	2	DOID:1184 (implicated_via_orthology)
Disease	Mammary Neoplasms, Human	SETD2 FN1 LOXL2 HNRNPL ROR1	4.77e-04	525	37	5	C1257931
Disease	Mammary Carcinoma, Human	SETD2 FN1 LOXL2 HNRNPL ROR1	4.77e-04	525	37	5	C4704874
Disease	Mammary Neoplasms	SETD2 FN1 LOXL2 HNRNPL ROR1	4.85e-04	527	37	5	C1458155
Disease	Breast Carcinoma	SETD2 FN1 LOXL2 HNRNPL ROR1	5.32e-04	538	37	5	C0678222
Disease	Parkinsonian Disorders	LYST POLG	6.51e-04	30	37	2	C0242422
Disease	Neoplastic Cell Transformation	FN1 LOXL2 NFKB1	7.07e-04	139	37	3	C0007621
Disease	Ovarian Cysts	AMELY NFKB1	8.87e-04	35	37	2	C0029927
Disease	Corpus Luteum Cyst	AMELY NFKB1	8.87e-04	35	37	2	C0010093
Disease	Mood Disorders	TBC1D25 POLG NFKB1	1.22e-03	168	37	3	C0525045
Disease	Secondary Biliary Cholangitis	LOXL2 NFKB1	1.28e-03	42	37	2	C0238065
Disease	Biliary Cirrhosis, Primary, 1	LOXL2 NFKB1	1.28e-03	42	37	2	C4551595
Disease	Biliary cirrhosis	LOXL2 NFKB1	1.28e-03	42	37	2	C0023892
Disease	Primary biliary cirrhosis	LOXL2 NFKB1	1.60e-03	47	37	2	C0008312
Disease	Male sterility	DROSHA POLG	1.66e-03	48	37	2	C0917731
Disease	Male infertility	DROSHA POLG	1.66e-03	48	37	2	C0021364

Protein segments in the cluster

Peptide	Gene	Start	Entry
PHPGHPGYINFSYEV	AMELX	21	Q99217
PHPGHPGYINFSYEN	AMELY	21	Q99218
FGNFPHYSRFHPPEQ	BCDIN3D	31	Q7Z5W3
HAPYPPGYQRHFEAP	FAT1	4516	Q14517
VYHPYGPQPHLGADT	HOXC9	76	P31274
PFHGVYHSHPGNPSN	MALT1	756	Q9UDY8
PHYPEYFQQPAPEYH	LOXL2	31	Q9Y4K0
HGYKPHFVPNFNGPN	FAM83B	356	Q5T0W9
DFHNPGYPKYLGTPH	FAM83D	501	Q9H4H8
SYHHGNGPYNDVDIP	POLG	731	P54098
IHNGPPHNSNFGYSY	GFUS	131	Q13630
FSSLYPHHQFGPFPH	IGF2BP2	406	Q9Y6M1
PPGQDFQHGYAGVFH	CAPN12	126	Q6ZSI9
DYHLYPHGPGLNPNA	FN1	2186	P02751
KGEFYSENHHNPPPF	BPI	256	P17213
PPVQPYHYGSHYSNS	LYST	3226	Q99698
LNPQNPHYIPGYTGH	FAM166B	11	A8MTA8
SHYHDEGYGPPPPHY	HNRNPL	326	P14866
NSHPFPGAAGYPTYR	KIRREL1	691	Q96J84
HQNYIAPSGHYSQGP	SEC24B	61	O95487
AHFGNPEAAHPAPLY	INSM1	86	Q01101
AAAAFPHPHPAFYPY	IRX3	106	P78415
PHPHPAFYPYGQYQF	IRX3	111	P78415
FGSVHQDYPSYPGFP	EYA2	156	O00167
PHGSLQGYQTYGHFP	NR5A2	251	O00482
GYSHHNFPPPSFNSF	DROSHA	171	Q9NRR4
DRAHPYYAGPEDGPH	TBC1D25	296	Q3MII6
PHLPPYSAYDFQHSG	TMEM255A	286	Q5JRV8
VPHQGQYLHPPYVGY	SHISA2	236	Q6UWI4
FGPPLPSYFAHFHSG	PRR32	271	B1ATL7
PPEPGQAYGGAYFHA	SOX8	296	P57073
SFHHPYFLPGPHYFP	SOX30	611	O94993
CPGSPDHQVPYGHDY	TRAF3IP2	276	O43734
PGYAAFPAAHYQPTG	ROR1	826	Q01973
PAPRPFHHGQYYGYL	IGSF9B	956	Q9UPX0
PYDSLGYNAPHHPFA	SETD2	2151	Q9BYW2
GYNAPHHPFAGYPPG	SETD2	2156	Q9BYW2
HSYPGAYLSPGFHYP	ZNF608	1371	Q9ULD9
YGHFPFFRAYLGPHP	KEL	201	P23276
FPHYGFPTYGGITFH	NFKB1	406	P19838
YGNGYSKAGIPQHHP	NECTIN1	396	Q15223