Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	sister chromatid biorientation	BOD1 RB1	1.94e-05	3	53	2	GO:0031134
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	RB1 CDK13	2.33e-04	9	54	2	GO:0008024
GeneOntologyCellularComponent	SCAR complex	ABI1 ABI2	4.25e-04	12	54	2	GO:0031209
GeneOntologyCellularComponent	sperm fibrous sheath	GAPDHS FSCB	5.02e-04	13	54	2	GO:0035686
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	RB1 CDK13 CCNB1	5.27e-04	61	54	3	GO:0000307
GeneOntologyCellularComponent	Set1C/COMPASS complex	BOD1 SETD1A	7.68e-04	16	54	2	GO:0048188
GeneOntologyCellularComponent	nuclear speck	SETD1A CDK13 YLPM1 ZC3H18 VIRMA AKAP8L	8.30e-04	431	54	6	GO:0016607
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	RB1 CDK13	9.76e-04	18	54	2	GO:0019908
GeneOntologyCellularComponent	filopodium tip	ABI1 ABI2	1.21e-03	20	54	2	GO:0032433
GeneOntologyCellularComponent	carboxy-terminal domain protein kinase complex	RB1 CDK13	1.74e-03	24	54	2	GO:0032806
GeneOntologyCellularComponent	outer kinetochore	BOD1 CCNB1	1.74e-03	24	54	2	GO:0000940
GeneOntologyCellularComponent	nuclear body	SETD1A RB1 CDK13 YLPM1 PTPN23 ZC3H18 VIRMA AKAP8L	2.10e-03	903	54	8	GO:0016604
GeneOntologyCellularComponent	methyltransferase complex	BOD1 SETD1A VIRMA	2.75e-03	108	54	3	GO:0034708
GeneOntologyCellularComponent	lamellipodium	FAT1 ABI1 ABI2 APBB1IP	2.94e-03	230	54	4	GO:0030027
Domain	Abl-interactor_HHR_dom	ABI1 ABI2	2.37e-05	3	53	2	IPR012849
Domain	Abi_HHR	ABI1 ABI2	2.37e-05	3	53	2	PF07815
Domain	CYCLIN	CABLES2 RB1 CCNB1	1.70e-04	38	53	3	SM00385
Domain	-	CABLES2 RB1 CCNB1	1.98e-04	40	53	3	1.10.472.10
Domain	Cyclin-like	CABLES2 RB1 CCNB1	2.46e-04	43	53	3	IPR013763
Domain	T_SNARE	ABI1 ABI2	2.46e-03	26	53	2	PS50192
Domain	T_SNARE_dom	ABI1 ABI2	3.05e-03	29	53	2	IPR000727
Domain	Cyclin_N	CABLES2 CCNB1	3.94e-03	33	53	2	IPR006671
Domain	Cyclin_N	CABLES2 CCNB1	3.94e-03	33	53	2	PF00134
Domain	SANT	NCOR1 CHD7	8.87e-03	50	53	2	SM00717
Domain	SANT/Myb	NCOR1 CHD7	9.57e-03	52	53	2	IPR001005
Pathway	PID_HES_HEY_PATHWAY	NCOR1 RB1 SPEN KDM1A	9.88e-06	48	40	4	M288
Pathway	PID_ECADHERIN_STABILIZATION_PATHWAY	ABI1 ZYX VCL	2.09e-04	41	40	3	M232
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	BOD1 SETD1A AKAP8L	2.25e-04	42	40	3	M48018
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOR1 OTUD5 CDK13 YLPM1 ZC3H18 CHD7 SPEN VIRMA ZYX AKAP8L HOMEZ	2.48e-08	774	54	11	15302935
Pubmed	Human transcription factor protein interaction networks.	SETD1A NCOR1 FAT1 RB1 DGKK YLPM1 STIP1 ZC3H18 CHD7 SPEN AKAP8L KDM1A VCL HOMEZ	2.55e-08	1429	54	14	35140242
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD1A NCOR1 YLPM1 PTPN23 SPEN ZYX KDM1A VCL HTT	1.61e-07	549	54	9	38280479
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	NCOR1 RB1 OTUD5 TACC2 STIP1 ZC3H18 CHD7 SPEN KDM1A	2.87e-07	588	54	9	38580884
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	ABI1 OTUD5 CDK13 PTPN23 STIP1 ZC3H18 GAPDHS SPEN KDM1A	7.99e-07	665	54	9	30457570
Pubmed	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.	NCOR1 FAT1 ABI1 STIP1 ZYX AKAP8L VCL	8.17e-07	332	54	7	29053956
Pubmed	Interaction network of human early embryonic transcription factors.	SETD1A NCOR1 CHD7 SPEN AKAP8L KDM1A HOMEZ	1.18e-06	351	54	7	38297188
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOR1 ZNF219 ABI1 ABI2 FXR2 YLPM1 STIP1 CHD7 VIRMA KDM1A	2.01e-06	963	54	10	28671696
Pubmed	Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV.	ZNF358 MCOLN1	2.37e-06	2	54	2	11013137
Pubmed	Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.	ABI1 ABI2	2.37e-06	2	54	2	16401422
Pubmed	RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner.	RABL6 RB1	2.37e-06	2	54	2	34065204
Pubmed	The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.	ABI1 ABI2	2.37e-06	2	54	2	11516653
Pubmed	Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism.	KDM1A VCL	2.37e-06	2	54	2	35856020
Pubmed	RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1.	RABL6 RB1	2.37e-06	2	54	2	26676380
Pubmed	A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.	NCOR1 SPEN	2.37e-06	2	54	2	12897056
Pubmed	RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner.	RABL6 RB1	2.37e-06	2	54	2	25273089
Pubmed	The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state.	SETD1A KDM1A	2.37e-06	2	54	2	27174370
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	NCOR1 ZNF219 FXR2 YLPM1 CHD7 AKAP8L KDM1A	3.36e-06	411	54	7	35182466
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	NCOR1 CHD7 SPEN KDM1A	6.80e-06	78	54	4	28611094
Pubmed	RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.	APBB1IP VCL	7.09e-06	3	54	2	23389036
Pubmed	Regulation of cell-cell adhesion by Abi/Diaphanous complexes.	ABI1 ABI2	7.09e-06	3	54	2	19158278
Pubmed	Actomyosin-generated tension controls the molecular kinetics of focal adhesions.	ZYX VCL	7.09e-06	3	54	2	21486952
Pubmed	Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp.	RB1 KDM1A	7.09e-06	3	54	2	18216119
Pubmed	Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.	AKAP8L HTT	7.09e-06	3	54	2	16391387
Pubmed	In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).	ABI1 ABI2	7.09e-06	3	54	2	12011975
Pubmed	Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation.	NCOR1 HTT	7.09e-06	3	54	2	12799135
Pubmed	Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.	APBB1IP VCL	7.09e-06	3	54	2	32561773
Pubmed	Expression of the phagocytic receptors αMβ2 and αXβ2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.	APBB1IP VCL	7.09e-06	3	54	2	36238292
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FXR2 YLPM1 ZC3H18 CHD7 SPEN VIRMA KDM1A VCL	7.19e-06	653	54	8	22586326
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOR1 CHD7 SPEN KDM1A	8.71e-06	83	54	4	28794006
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	NCOR1 RB1 CHD7 SPEN KDM1A	9.80e-06	183	54	5	36129980
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	NCOR1 SPEN KDM1A	1.39e-05	30	54	3	26593974
Pubmed	Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.	ABI1 ZYX	1.42e-05	4	54	2	12672821
Pubmed	Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.	NCOR1 HTT	1.42e-05	4	54	2	10441327
Pubmed	Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.	ABI1 ABI2	1.42e-05	4	54	2	15143189
Pubmed	Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.	ABI1 ABI2	1.42e-05	4	54	2	10995551
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	NUTM1 ABI2 FXR2 RTN4 ZYX VCL HOMEZ	1.44e-05	514	54	7	29892012
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	RB1 RTN4 YLPM1 CHD7 KDM1A CCNB1	1.94e-05	358	54	6	32460013
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	FAT1 FXR2 CDK13 STIP1 ZC3H18 SPEN	2.04e-05	361	54	6	26167880
Pubmed	ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.	ABI1 ABI2	2.36e-05	5	54	2	15572692
Pubmed	Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.	ABI1 ABI2	2.36e-05	5	54	2	21173240
Pubmed	Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice.	SETD1A KDM1A	2.36e-05	5	54	2	31606247
Pubmed	Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression.	NCOR1 RB1	2.36e-05	5	54	2	12466959
Pubmed	Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.	RB1 CCNB1	3.54e-05	6	54	2	9315635
Pubmed	Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin.	ZYX VCL	3.54e-05	6	54	2	10882740
Pubmed	Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.	SPEN KDM1A	3.54e-05	6	54	2	29977079
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZNF219 FXR2 YLPM1 ZC3H18 SPEN VIRMA AKAP8L	4.06e-05	605	54	7	28977666
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	SETD1A FXR2 CDK13 YLPM1 CHD7 SPEN	4.14e-05	410	54	6	26949251
Pubmed	Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.	ABI1 ABI2	4.94e-05	7	54	2	35108541
Pubmed	The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity.	RB1 CCNB1	4.94e-05	7	54	2	9053846
Pubmed	The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.	NCOR1 SPEN	4.94e-05	7	54	2	11867749
Pubmed	A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.	NCOR1 AKAP8L	4.94e-05	7	54	2	16980585
Pubmed	Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing spinal cord.	RB1 CCNB1	4.94e-05	7	54	2	7624053
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SETD1A NCOR1 RASAL3 YLPM1 CHD7 SPEN	5.39e-05	430	54	6	35044719
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1A FXR2 YLPM1 AKAP8L KDM1A MAP3K4	6.12e-05	440	54	6	34244565
Pubmed	Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.	RB1 CCNB1	6.59e-05	8	54	2	10339564
Pubmed	Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.	RB1 CCNB1	6.59e-05	8	54	2	15024056
Pubmed	Structure and control of the actin regulatory WAVE complex.	ABI1 ABI2	6.59e-05	8	54	2	21107423
Pubmed	Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.	ZYX VCL	6.59e-05	8	54	2	24036928
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	FXR2 CDK13 YLPM1 ZC3H18 ZYX AKAP8L KDM1A	6.69e-05	655	54	7	35819319
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	NCOR1 YLPM1 ZC3H18 CHD7 SPEN	7.86e-05	283	54	5	30585729
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	NCOR1 ZNF219 CHD7 KDM1A	8.01e-05	146	54	4	23892456
Pubmed	Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.	FAT1 VCL	8.46e-05	9	54	2	15148305
Pubmed	The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.	RB1 CCNB1	8.46e-05	9	54	2	22157815
Pubmed	Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.	ZYX VCL	8.46e-05	9	54	2	8861907
Pubmed	Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.	RB1 CCNB1	8.46e-05	9	54	2	12676926
Pubmed	The functional interactome landscape of the human histone deacetylase family.	NCOR1 RB1 YLPM1 AKAP8L KDM1A	8.67e-05	289	54	5	23752268
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SETD1A CDK13 ZC3H18 CHD7 SPEN CCNB1	8.70e-05	469	54	6	27634302
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ABI1 ABI2 CDK13 STIP1 CHD7 SPEN VIRMA AKAP8L KDM1A B3GAT3	8.98e-05	1497	54	10	31527615
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	SPEG CHD7 VIRMA HOMEZ	9.60e-05	153	54	4	10718198
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	ABI1 YLPM1 VIRMA APBB1IP	9.84e-05	154	54	4	16055720
Pubmed	NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.	ABI1 ABI2	1.06e-04	10	54	2	17101133
Pubmed	PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.	RB1 CCNB1	1.06e-04	10	54	2	9885575
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RABL6 SPEG RTN4 AKAP8L KDM1A MAP3K4	1.19e-04	497	54	6	36774506
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CDK13 RTN4 PTPN23 STIP1 ZYX KDM1A	1.21e-04	498	54	6	36634849
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FXR2 RTN4 YLPM1 SPEN ZYX VCL CCNB1	1.25e-04	724	54	7	36232890
Pubmed	Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.	NCOR1 SPEN	1.29e-04	11	54	2	11331609
Pubmed	SRF is essential for mesodermal cell migration during elongation of the embryonic body axis.	ZYX VCL	1.29e-04	11	54	2	25020278
Pubmed	Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.	RB1 CCNB1	1.29e-04	11	54	2	8662825
Pubmed	Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.	RB1 CCNB1	1.55e-04	12	54	2	23543736
Pubmed	Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein.	RB1 CCNB1	1.55e-04	12	54	2	8552401
Pubmed	Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.	RB1 CCNB1	1.55e-04	12	54	2	21148318
Pubmed	Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.	ZYX VCL	1.55e-04	12	54	2	15465019
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	NCOR1 ZNF219 CDK13 YLPM1 ZC3H18 CHD7 SPEN KDM1A HOMEZ	1.56e-04	1294	54	9	30804502
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	ZNF219 FXR2 ZC3H18 AKAP8L HOMEZ	1.61e-04	330	54	5	33301849
Pubmed	p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis.	RB1 CCNB1	1.83e-04	13	54	2	22154697
Pubmed	Loss of migfilin expression has no overt consequences on murine development and homeostasis.	ZYX VCL	1.83e-04	13	54	2	21224394
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	SETD1A KDM1A	1.83e-04	13	54	2	24619213
Pubmed	Cyclin-binding motifs are essential for the function of p21CIP1.	RB1 CCNB1	1.83e-04	13	54	2	8756624
Pubmed	An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.	NCOR1 RTN4	1.83e-04	13	54	2	18986647
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SETD1A NCOR1 YLPM1 ZC3H18 SPEN	1.88e-04	341	54	5	32971831
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	NCOR1 ABI2 PPM1E YLPM1 PTPN23 STIP1 ZYX AKAP8L	2.03e-04	1049	54	8	27880917
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	RB1 CDK13 HTT CCNB1	2.03e-04	186	54	4	33637726
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	ZNF219 RB1 ABI2	2.04e-04	73	54	3	22094256
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MRPS30 NCOR1 ABI1 RTN4 KDM1A CCNB1	2.28e-04	560	54	6	35241646
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FXR2 CDK13 YLPM1 ZC3H18 SPEN VIRMA AKAP8L	2.42e-04	807	54	7	22681889
Pubmed	High-resolution genetic mapping of the gunmetal gene which regulates platelet production.	RB1 VCL	2.45e-04	15	54	2	8833241
Pubmed	Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.	NCOR1 HTT	2.45e-04	15	54	2	11092755
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	FXR2 CDK13 CHD7 VIRMA	2.53e-04	197	54	4	20811636
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	YLPM1 PTPN23 ZC3H18 VIRMA	2.78e-04	202	54	4	24639526
Interaction	VASP interactions	FAT1 ABI1 ABI2 PSORS1C2 PTPN23 STIP1 VIRMA ZYX APBB1IP VCL	5.09e-09	294	54	10	int:VASP
Interaction	PRPF40A interactions	RABL6 ABI1 CDK13 YLPM1 ZC3H18 SPEN VIRMA AKAP8L APBB1IP VCL HTT	2.24e-08	446	54	11	int:PRPF40A
Interaction	HOMER3 interactions	FAT1 ABI1 ABI2 FXR2 PSORS1C2 KDM1A HTT	9.06e-08	140	54	7	int:HOMER3
Interaction	KIAA1217 interactions	ABI1 ABI2 FXR2 VIRMA ZYX KDM1A	6.25e-07	115	54	6	int:KIAA1217
Interaction	ENAH interactions	FAT1 ABI1 ABI2 VIRMA ZYX VCL	1.07e-06	126	54	6	int:ENAH
Interaction	YWHAZ interactions	NCOR1 ABI1 RASAL3 SASH1 ABI2 SPEG TACC2 STIP1 ZC3H18 GAPDHS VIRMA VCL MAP3K4 HTT HOMEZ	1.22e-06	1319	54	15	int:YWHAZ
Interaction	MTA2 interactions	RABL6 SETD1A ZNF219 STIP1 CHD7 SPEN VIRMA KDM1A HTT	2.11e-06	435	54	9	int:MTA2
Interaction	RBBP4 interactions	SETD1A NCOR1 ZNF219 RB1 STIP1 ZC3H18 CHD7 SPEN VIRMA KDM1A	2.48e-06	573	54	10	int:RBBP4
Interaction	EVL interactions	ABI1 FXR2 ZYX APBB1IP HTT	2.83e-06	83	54	5	int:EVL
Interaction	PRKAA2 interactions	NUTM1 ABI1 RASAL3 ABI2 PPM1E AKAP8L HOMEZ	3.62e-06	242	54	7	int:PRKAA2
Interaction	PRMT2 interactions	SETD1A RB1 PPM1E YLPM1 HTT	4.46e-06	91	54	5	int:PRMT2
Interaction	KDM5B interactions	NCOR1 RB1 VIRMA KDM1A HTT	7.09e-06	100	54	5	int:KDM5B
Interaction	TNIK interactions	ZNF219 ABI1 ABI2 FXR2 PPM1E VIRMA KDM1A HTT	7.38e-06	381	54	8	int:TNIK
Interaction	TRIM14 interactions	NCOR1 FAT1 ABI1 STIP1 ZYX AKAP8L KDM1A VCL	7.67e-06	383	54	8	int:TRIM14
Interaction	RBBP5 interactions	BOD1 SETD1A RB1 CHD7 SPEN VIRMA KDM1A	1.10e-05	287	54	7	int:RBBP5
Interaction	CTBP1 interactions	NCOR1 ZNF219 RB1 RTN4 SPEN VIRMA KDM1A HTT	1.17e-05	406	54	8	int:CTBP1
Interaction	TBXT interactions	NCOR1 CHD7 SPEN KDM1A HOMEZ	1.46e-05	116	54	5	int:TBXT
Interaction	HDAC2 interactions	NCOR1 ZNF219 RB1 FXR2 STIP1 ZC3H18 SPEN VIRMA ZYX KDM1A VCL	1.51e-05	865	54	11	int:HDAC2
Interaction	ATXN1 interactions	NCOR1 ABI1 OTUD5 CDK13 PTPN23 STIP1 ZC3H18 GAPDHS SPEN VIRMA ZYX KDM1A	1.52e-05	1039	54	12	int:ATXN1
Interaction	CYFIP1 interactions	ABI1 ABI2 FXR2 YLPM1 STIP1 VIRMA APBB1IP	1.57e-05	303	54	7	int:CYFIP1
Interaction	WASF3 interactions	ABI1 RASAL3 ABI2 VIRMA	1.64e-05	57	54	4	int:WASF3
Interaction	RABGEF1 interactions	NCOR1 RASAL3 ABI2 OTUD5 PTPN23 GAPDHS	1.72e-05	204	54	6	int:RABGEF1
Interaction	TTC23 interactions	NUTM1 ABI1 RB1 PSORS1C2 KDM1A HTT	1.92e-05	208	54	6	int:TTC23
Interaction	MRTFA interactions	VIRMA ZYX KDM1A VCL	2.01e-05	60	54	4	int:MRTFA
Interaction	YWHAE interactions	ABI1 RASAL3 SASH1 ABI2 CDK13 TACC2 STIP1 ZC3H18 VIRMA ZYX SYDE1 VCL HTT	2.02e-05	1256	54	13	int:YWHAE
Interaction	SIRT7 interactions	RB1 FXR2 YLPM1 ZC3H18 CHD7 SPEN VIRMA KDM1A VCL CCNB1	2.43e-05	744	54	10	int:SIRT7
Interaction	THOC2 interactions	STIP1 ZC3H18 SPEN VIRMA KDM1A VCL	2.57e-05	219	54	6	int:THOC2
Interaction	RAPH1 interactions	ABI1 ABI2 VIRMA KDM1A	2.60e-05	64	54	4	int:RAPH1
Interaction	TRIML2 interactions	ABI2 STIP1 SPEN KDM1A	2.76e-05	65	54	4	int:TRIML2
Interaction	CHD4 interactions	RABL6 SETD1A ZNF219 FXR2 YLPM1 STIP1 ZC3H18 SPEN VIRMA AKAP8L KDM1A	3.19e-05	938	54	11	int:CHD4
Interaction	ARHGAP12 interactions	ABI1 ABI2 YLPM1 VIRMA	3.30e-05	68	54	4	int:ARHGAP12
Interaction	SH3D19 interactions	PTPN23 VIRMA ZYX KDM1A	3.50e-05	69	54	4	int:SH3D19
Interaction	CLMN interactions	RTN4 VIRMA ZYX VCL	3.50e-05	69	54	4	int:CLMN
Interaction	HOMER1 interactions	FAT1 ABI1 RASAL3 VIRMA HTT	3.62e-05	140	54	5	int:HOMER1
Interaction	CRYBG3 interactions	VIRMA ZYX KDM1A VCL	3.70e-05	70	54	4	int:CRYBG3
Interaction	KIF5B interactions	NCOR1 ZFHX2 PTPN23 TACC2 VIRMA KDM1A HTT	3.80e-05	348	54	7	int:KIF5B
Interaction	SMARCD1 interactions	NUTM1 NCOR1 ABI1 ABI2 VIRMA KDM1A HOMEZ	3.87e-05	349	54	7	int:SMARCD1
Interaction	GFAP interactions	NCOR1 ABI2 FXR2 HTT HOMEZ CCNB1	3.91e-05	236	54	6	int:GFAP
Interaction	SMARCC2 interactions	RABL6 NCOR1 YLPM1 STIP1 CHD7 VIRMA KDM1A	4.16e-05	353	54	7	int:SMARCC2
Interaction	NFASC interactions	ABI1 ABI2 HTT	4.53e-05	26	54	3	int:NFASC
Interaction	NAV1 interactions	VIRMA SYDE1 KDM1A VCL CCNB1	4.88e-05	149	54	5	int:NAV1
Interaction	SP1 interactions	NCOR1 FAT1 RB1 ZC3H18 SPEN HTT CCNB1	5.14e-05	365	54	7	int:SP1
Interaction	LMO1 interactions	NUTM1 ZNF219 ABI1 ABI2 HOMEZ	5.71e-05	154	54	5	int:LMO1
Interaction	KHDRBS1 interactions	SASH1 ABI2 FXR2 YLPM1 STIP1 VIRMA KDM1A	5.89e-05	373	54	7	int:KHDRBS1
Interaction	EP300 interactions	RABL6 NUTM1 SETD1A NCOR1 RB1 RTN4 YLPM1 TACC2 STIP1 VIRMA ZYX KDM1A CCNB1	6.31e-05	1401	54	13	int:EP300
Interaction	ABL1 interactions	CABLES2 MICAL1 ABI1 RB1 ABI2 VIRMA	6.55e-05	259	54	6	int:ABL1
Interaction	TIMM50 interactions	ABI1 ABI2 STIP1 ZC3H18 VIRMA KDM1A	6.83e-05	261	54	6	int:TIMM50
Interaction	RNF40 interactions	RB1 ZC3H18 GAPDHS SPEN VIRMA KDM1A	6.83e-05	261	54	6	int:RNF40
Interaction	NCK2 interactions	MICAL1 ABI1 ABI2 FXR2 YLPM1 HOMEZ	6.98e-05	262	54	6	int:NCK2
Interaction	PRRT3 interactions	PRRT2 VIRMA	7.01e-05	5	54	2	int:PRRT3
Interaction	ATP8A1 interactions	PRRT2 VIRMA HTT	7.01e-05	30	54	3	int:ATP8A1
Interaction	SMARCC1 interactions	RABL6 NCOR1 YLPM1 STIP1 CHD7 VIRMA KDM1A	7.07e-05	384	54	7	int:SMARCC1
Interaction	MKRN2 interactions	RB1 RTN4 STIP1 ZC3H18 CHD7 KDM1A CCNB1	7.19e-05	385	54	7	int:MKRN2
Interaction	ZNF451 interactions	FXR2 VIRMA KDM1A HTT	7.23e-05	83	54	4	int:ZNF451
Interaction	ALMS1 interactions	PTPN23 VIRMA ZYX KDM1A VCL	7.69e-05	164	54	5	int:ALMS1
Interaction	ARHGAP11B interactions	STIP1 VIRMA ZYX	7.75e-05	31	54	3	int:ARHGAP11B
Interaction	CHST15 interactions	RABL6 VIRMA CCNB1	7.75e-05	31	54	3	int:CHST15
Interaction	USF1 interactions	SETD1A TCFL5 MAP3K4 HOMEZ	7.94e-05	85	54	4	int:USF1
Interaction	AXIN1 interactions	NUTM1 FXR2 MAP3K4 HTT HOMEZ	8.15e-05	166	54	5	int:AXIN1
Interaction	FMR1 interactions	NCOR1 ZNF219 FXR2 TACC2 STIP1 CHD7 VIRMA KDM1A	8.43e-05	536	54	8	int:FMR1
Interaction	POLR2A interactions	SETD1A OTUD5 STIP1 VIRMA AKAP8L SYDE1 KDM1A HTT	8.43e-05	536	54	8	int:POLR2A
Interaction	N4BP2 interactions	VIRMA ZYX KDM1A VCL	9.49e-05	89	54	4	int:N4BP2
Interaction	HSPB1 interactions	ABI1 FXR2 STIP1 ZC3H18 VIRMA ZYX AKAP8L KDM1A HTT	9.99e-05	708	54	9	int:HSPB1
Interaction	SECISBP2L interactions	SASH1 VIRMA ZYX	1.03e-04	34	54	3	int:SECISBP2L
Interaction	TERF2IP interactions	SETD1A NCOR1 RB1 CDK13 ZC3H18 CHD7 SPEN KDM1A	1.03e-04	552	54	8	int:TERF2IP
Interaction	MRFAP1 interactions	ABI1 RB1 ABI2 HTT	1.04e-04	91	54	4	int:MRFAP1
Interaction	SLC25A3 interactions	MRPS30 ABI1 STIP1 ZC3H18 PRRT2 VIRMA HTT	1.08e-04	411	54	7	int:SLC25A3
Interaction	KCNA1 interactions	RTN4 PRRT2 HTT	1.12e-04	35	54	3	int:KCNA1
Interaction	NFKBIL1 interactions	SETD1A ZC3H18 CHD7 SPEN	1.13e-04	93	54	4	int:NFKBIL1
Interaction	MCM7 interactions	SETD1A RB1 ABI2 STIP1 VIRMA KDM1A HTT	1.13e-04	414	54	7	int:MCM7
Interaction	DNM2 interactions	ABI1 FXR2 STIP1 PRRT2 VIRMA HTT	1.17e-04	288	54	6	int:DNM2
Interaction	PURA interactions	ABI1 RB1 STIP1 ZC3H18 HTT CCNB1	1.24e-04	291	54	6	int:PURA
Interaction	KANSL1 interactions	NUTM1 SETD1A VIRMA KDM1A	1.27e-04	96	54	4	int:KANSL1
Interaction	MBD3 interactions	NUTM1 ZNF219 ZC3H18 SPEN VIRMA KDM1A	1.34e-04	295	54	6	int:MBD3
Interaction	CCAR1 interactions	RB1 STIP1 VIRMA ZYX CCNB1	1.43e-04	187	54	5	int:CCAR1
Interaction	ZSCAN5A interactions	NCOR1 GAPDHS KDM1A	1.44e-04	38	54	3	int:ZSCAN5A
Interaction	SLC25A5 interactions	ABI1 RTN4 PPM1E STIP1 ZC3H18 VIRMA HTT	1.45e-04	431	54	7	int:SLC25A5
Interaction	FICD interactions	VIRMA HTT	1.47e-04	7	54	2	int:FICD
Interaction	GPANK1 interactions	NUTM1 ABI2 AKAP8L HOMEZ	1.49e-04	100	54	4	int:GPANK1
Interaction	RAB10 interactions	MICAL1 RTN4 PRRT2 VIRMA HTT	1.54e-04	190	54	5	int:RAB10
Interaction	CCR4 interactions	FXR2 RTN4 B3GAT3	1.55e-04	39	54	3	int:CCR4
Interaction	CRACD interactions	ZC3H18 VIRMA ZYX	1.67e-04	40	54	3	int:CRACD
Interaction	KIAA1671 interactions	FXR2 VIRMA ZYX KDM1A VCL	1.69e-04	194	54	5	int:KIAA1671
Interaction	LUZP1 interactions	FXR2 VIRMA ZYX KDM1A APBB1IP	1.69e-04	194	54	5	int:LUZP1
Interaction	KIF21A interactions	TACC2 VIRMA MAP3K4 HTT	1.80e-04	105	54	4	int:KIF21A
Interaction	PTK2 interactions	MICAL1 PTPN23 STIP1 APBB1IP VCL HTT	1.91e-04	315	54	6	int:PTK2
Interaction	TUBB3 interactions	RABL6 FXR2 CDK13 PRRT2 VIRMA VCL HTT	1.97e-04	453	54	7	int:TUBB3
Interaction	SYNGR1 interactions	SLC16A2 PRRT2 B3GAT3 HTT	2.08e-04	109	54	4	int:SYNGR1
Interaction	PYCR1 interactions	SETD1A STIP1 ZC3H18 VIRMA SYDE1	2.09e-04	203	54	5	int:PYCR1
Interaction	CNP interactions	CDK13 STIP1 PRRT2 VIRMA HTT	2.09e-04	203	54	5	int:CNP
Interaction	IRF2BP2 interactions	NCOR1 STIP1 SPEN VIRMA	2.15e-04	110	54	4	int:IRF2BP2
Interaction	RBM25 interactions	RABL6 ZC3H18 SPEN VIRMA SYDE1 HTT	2.19e-04	323	54	6	int:RBM25
Interaction	AMZ1 interactions	ABI1 ABI2 VIRMA	2.23e-04	44	54	3	int:AMZ1
Interaction	SORBS2 interactions	FAT1 ABI1 VIRMA VCL	2.23e-04	111	54	4	int:SORBS2
Interaction	TCERG1 interactions	SETD1A ABI1 STIP1 ZC3H18 HTT	2.29e-04	207	54	5	int:TCERG1
Interaction	USP24 interactions	STIP1 VIRMA KDM1A HTT	2.31e-04	112	54	4	int:USP24
Interaction	BCLAF1 interactions	ABI1 RTN4 ZC3H18 SPEN VIRMA CCNB1	2.34e-04	327	54	6	int:BCLAF1
Interaction	BAG2 interactions	SETD1A NCOR1 OTUD5 PTPN23 STIP1 SPEN VIRMA HTT	2.34e-04	622	54	8	int:BAG2
Interaction	P4HA3 interactions	NUTM1 FXR2 YLPM1 PDIA2	2.39e-04	113	54	4	int:P4HA3
Interaction	TRAP1 interactions	RB1 RTN4 STIP1 ZC3H18 VIRMA HTT CCNB1	2.40e-04	468	54	7	int:TRAP1
Cytoband	19p13.12	RASAL3 AKAP8L SYDE1	2.90e-05	50	54	3	19p13.12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX2 HOMEZ	4.68e-04	15	39	2	529
Drug	NSC-364372	ABI1 RB1 ABI2 FXR2 STIP1 GAPDHS ZYX VCL HTT CCNB1	1.78e-07	484	54	10	CID000435143
Drug	Foliosidine [2520-38-9]; Down 200; 13uM; PC3; HT_HG-U133A	SETD1A CDK13 ZNF358 YLPM1 ZYX SYDE1	7.11e-06	197	54	6	4295_DN
Drug	AC1O5PL5	CDK13 TCFL5 HTT	1.00e-05	18	54	3	CID006438380
Drug	trapoxin	NCOR1 GAPDHS TCFL5 KDM1A	1.09e-05	58	54	4	CID000121875
Disease	in situ carcinoma (is_marker_for)	RB1 CCNB1	6.75e-04	21	54	2	DOID:8719 (is_marker_for)
Disease	Malignant neoplasm of breast	NCOR1 MICAL1 RB1 PPM1E TACC2 SPEN MCOLN1 FSCB	7.06e-04	1074	54	8	C0006142
Disease	lymphocyte count	NCOR1 RASAL3 RB1 CDK13 RTN4 STIP1 CHD7 APBB1IP HTT	1.25e-03	1464	54	9	EFO_0004587
Disease	Movement Disorders	PRRT2 HTT	1.29e-03	29	54	2	C0026650
Disease	Intellectual Disability	RABL6 SETD1A PTPN23 PRRT2 HTT	1.34e-03	447	54	5	C3714756
Disease	intellectual disability (is_implicated_in)	SLC16A2 CDK13	1.38e-03	30	54	2	DOID:1059 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPPAPAQPPEPEALP	B3GAT3	61	O94766
DDFLPPPPPPPPLDD	APBB1IP	551	Q7Z5R6
PPLDDPELPPPPPDF	APBB1IP	561	Q7Z5R6
PPPPPPPPVDYEDEE	ABI1	411	Q8IZP0
PPPSPPPEEDEDPGV	CHD7	731	Q9P2D1
PPDQRPPEPPEPPPV	CDK13	1256	Q14004
PPEPPEPPPVTEEDL	CDK13	1261	Q14004
TPPPPPPVEEPVFDE	ABI2	401	Q9NYB9
PVFDESPPPPPPPED	ABI2	411	Q9NYB9
SPPPPPPPEDYEEEE	ABI2	416	Q9NYB9
SPPPPPPPEEEEEGA	AKAP8L	601	Q9ULX6
PESEPEPEPEPEPVP	SLC16A2	31	P36021
EPEPEPEPVPVPPPE	SLC16A2	36	P36021
PEPVPVPPPEPQPEP	SLC16A2	41	P36021
VPPPEPQPEPQPLPD	SLC16A2	46	P36021
PPQPPPPEPEPVEAD	SLC24A4	396	Q8NFF2
PAPPPPPPPEEDPEQ	RB1	21	P06400
PPPEPDPEPEQEAPE	RASAL3	96	Q86YV0
EDEGPAEPPPPPKLP	RABL6	601	Q3YEC7
PLPEAPQPKEEPPVP	PTPN23	1551	Q9H3S7
DCIQVDPPERPPPPP	MCOLN1	191	Q9GZU1
PPPPEDFPAADELPP	FAT1	4436	Q14517
PEPIPEPCPELAPGP	DGKK	51	Q5KSL6
EPEPPVDSEPGEPPP	FXR2	526	P51116
PPPAEEAPAEVQPPP	FSCB	636	Q5H9T9
EVPPDPEPGVPLTPP	MICAL1	671	Q8TDZ2
PEPEPEPEPEPEPEP	LAG3	506	P18627
EPPEEPAAPFPEPPA	PDIA2	501	Q13087
DPPDHPPREPPPQPI	NUTM1	36	Q86Y26
PEPEPEPEPEPEPES	PPM1E	31	Q8WY54
PPEPAPEPAPQPDPR	PRRT2	131	Q7Z6L0
PVPVSEPVPEPEPEP	CCNB1	91	P14635
EPVPEPEPEPEPEPV	CCNB1	96	P14635
PPPPPPGPAVAEEPL	HTT	71	P42858
LPPPPPQAPPEEENE	KDM1A	151	O60341
PAPPPEPEGQDPPAP	BOD1	166	Q96IK1
ESGDAEPPPQPPPPP	MARCHF11	16	A6NNE9
GRPPEEVPPPPVPAP	HOMEZ	146	Q8IX15
APPPPEPKAEVEPQP	GAPDHS	26	O14556
AEAREPPAPPPPEPP	CABLES2	76	Q9BTV7
PPDADPANEPPPPGP	OTUD5	11	Q96G74
PPPPPPEPETESEPE	MAP3K4	31	Q9Y6R4
SGLPPPPAEPEPEPE	MRPS30	116	Q9NP92
PPAEPEPEPEPEPEP	MRPS30	121	Q9NP92
DDEPPARPPPPPPAS	RTN4	136	Q9NQC3
PEPSPPEPEPQAPEG	SYDE1	36	Q6ZW31
PEEDPRPPAPEPPGP	SYDE1	116	Q6ZW31
DEEEEIATPPPPPPP	STIP1	191	P31948
PPEPEKPVSPPPVEQ	NCOR1	216	O75376
AAATEEPPPPLPPPP	NCOR1	601	O75376
RPPASEAPPPEPPEP	SETD1A	426	O15047
PPPPSEEEGPEEPPK	ZFHX2	2001	Q9C0A1
LPPPPQPAPVDEEPQ	SPEN	2431	Q96T58
PAPEPPAPEPPPEPT	SPEG	2911	Q15772
PEGEVPPPRPPPPEE	VCL	866	P18206
PEPEPEPEPEPEPAP	SASH1	11	O94885
EPEPEPEPAPEPEPE	SASH1	16	O94885
PEPAPEPEPEPKPGA	SASH1	21	O94885
PAPPPPPPEVIPEPE	TACC2	1966	O95359
PNEEVPPPLPPEEPQ	YLPM1	356	P49750
PPPLPPEEPQSEDPE	YLPM1	361	P49750
GEIPPPPPEDFPLPP	ZYX	61	Q15942
PEEEGGPEAPIPPPP	ZYX	121	Q15942
AEPPPAPRGPEPPEP	TCFL5	196	Q9UL49
PGPPPPDDDEDDPVP	VIRMA	186	Q69YN4
PQPEPRSVPQPEPEP	ZNF219	236	Q9P2Y4
GPVVDEILPPPPPEP	ZC3H18	281	Q86VM9
PSPDPDPVPSPDPNP	ZNF358	516	Q9NW07
PPRTDPPQPPRPDDP	PSORS1C2	86	Q9UIG4
QDPNWPPPPPPAPEE	KIAA1522	706	Q9P206