Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	SPAM1 FUCA1 GANAB	2.19e-04	103	23	3	GO:0004553
GeneOntologyMolecularFunction	purine ribonucleotide transmembrane transporter activity	SLC33A1 PANX1	3.16e-04	23	23	2	GO:0005346
GeneOntologyMolecularFunction	adenine nucleotide transmembrane transporter activity	SLC33A1 PANX1	4.06e-04	26	23	2	GO:0000295
GeneOntologyMolecularFunction	purine nucleotide transmembrane transporter activity	SLC33A1 PANX1	5.06e-04	29	23	2	GO:0015216
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	SPAM1 FUCA1 GANAB	5.85e-04	144	23	3	GO:0016798
GeneOntologyMolecularFunction	nucleotide transmembrane transporter activity	SLC33A1 PANX1	6.56e-04	33	23	2	GO:0015215
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	SLC33A1 PANX1	9.16e-04	39	23	2	GO:0015605
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC33A1 PANX1	2.09e-03	59	23	2	GO:1901505
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC33A1 PANX1	2.09e-03	59	23	2	GO:0015932
GeneOntologyMolecularFunction	hormone binding	TSPO GLP2R	6.21e-03	103	23	2	GO:0042562
GeneOntologyMolecularFunction	heme binding	STEAP4 DUOX2	1.34e-02	154	23	2	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	STEAP4 DUOX2	1.51e-02	164	23	2	GO:0046906
GeneOntologyMolecularFunction	transmembrane transporter binding	TSPO PANX1	1.66e-02	172	23	2	GO:0044325
GeneOntologyMolecularFunction	channel regulator activity	CNIH2 CNIH3	1.69e-02	174	23	2	GO:0016247
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR152 OXER1 GLP2R GPR174	1.73e-02	884	23	4	GO:0004930
GeneOntologyMolecularFunction	transporter regulator activity	CNIH2 CNIH3	1.75e-02	177	23	2	GO:0141108
GeneOntologyCellularComponent	endoplasmic reticulum membrane	TLCD3B SLC33A1 PANX1 CNIH2 CNIH3 HHATL IHH	3.47e-04	1293	23	7	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	TLCD3B SLC33A1 PANX1 CNIH2 CNIH3 HHATL IHH	3.57e-04	1299	23	7	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	TLCD3B SLC33A1 PANX1 CNIH2 CNIH3 HHATL IHH	4.07e-04	1327	23	7	GO:0042175
GeneOntologyCellularComponent	AMPA glutamate receptor complex	CNIH2 CNIH3	4.94e-04	30	23	2	GO:0032281
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	CNIH2 CNIH3	1.11e-03	45	23	2	GO:0008328
GeneOntologyCellularComponent	neurotransmitter receptor complex	CNIH2 CNIH3	1.37e-03	50	23	2	GO:0098878
GeneOntologyCellularComponent	coated vesicle membrane	SLC18A3 CNIH2 CNIH3	1.63e-03	215	23	3	GO:0030662
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	CNIH2 CNIH3	2.24e-03	64	23	2	GO:0012507
GeneOntologyCellularComponent	dendritic shaft	CNIH2 CNIH3	2.98e-03	74	23	2	GO:0043198
GeneOntologyCellularComponent	endoplasmic reticulum-Golgi intermediate compartment membrane	CNIH2 CNIH3	3.56e-03	81	23	2	GO:0033116
GeneOntologyCellularComponent	transport vesicle membrane	SLC18A3 CNIH2 CNIH3	3.92e-03	293	23	3	GO:0030658
Domain	CORNICHON	CNIH2 CNIH3	4.35e-06	3	23	2	PS01340
Domain	Cornichon_conserved	CNIH2 CNIH3	4.35e-06	3	23	2	IPR033466
Domain	Cornichon	CNIH2 CNIH3	8.69e-06	4	23	2	SM01398
Domain	Cornichon	CNIH2 CNIH3	8.69e-06	4	23	2	PF03311
Domain	Cornichon	CNIH2 CNIH3	8.69e-06	4	23	2	IPR003377
Domain	Glycoside_hydrolase_SF	SPAM1 FUCA1 GANAB	3.67e-05	53	23	3	IPR017853
Domain	Fe3_Rdtase_TM_dom	STEAP4 DUOX2	9.50e-05	12	23	2	IPR013130
Domain	Ferric_reduct	STEAP4 DUOX2	9.50e-05	12	23	2	PF01794
Domain	MFS_dom	SLC18A3 SLC33A1	1.17e-02	134	23	2	IPR020846
Pubmed	Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production.	DUOX2 PANX1	4.18e-07	2	23	2	26823467
Pubmed	Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia.	CNIH2 CNIH3	1.25e-06	3	23	2	23103966
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	GPR152 OXER1 GPR174	3.76e-06	46	23	3	12044878
Pubmed	Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.	CNIH2 CNIH3	6.26e-06	6	23	2	20805473
Pubmed	Cornichon proteins determine the subunit composition of synaptic AMPA receptors.	CNIH2 CNIH3	6.26e-06	6	23	2	23522044
Cytoband	11q13.2	GPR152 CNIH2	2.56e-04	47	23	2	11q13.2
GeneFamily	G protein-coupled receptors, Class A orphans	GPR152 GPR174	1.62e-03	78	14	2	262
GeneFamily	Solute carriers	SLC18A3 SLC33A1 SLC35F5	3.15e-03	395	14	3	752
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX2 IHH	2.09e-05	9	23	2	DOID:0050338 (implicated_via_orthology)
Disease	peptide measurement	TPGS2 SPAM1	3.25e-03	109	23	2	EFO_0010520
Disease	ferritin measurement	DUOX2 GLP2R	3.86e-03	119	23	2	EFO_0004459
Disease	cataract	TLCD3B SLC33A1	5.37e-03	141	23	2	MONDO_0005129
Disease	Endometriosis	CNIH3 IHH	6.94e-03	161	23	2	C0014175
Disease	Endometrioma	CNIH3 IHH	6.94e-03	161	23	2	C0269102
Disease	neutrophil measurement	TSPO SPAM1	8.33e-03	177	23	2	EFO_0803548

Protein segments in the cluster

Peptide	Gene	Start	Entry
PYRLLLGLEYALLVW	SLC33A1	381	O00400
WRYLHAVLGLLPPYR	DNHD1	81	Q96M86
IYQHLLYVRHFLWGL	RADIL	796	Q96JH8
LLLQARLYFHLGIWP	FBXO21	426	O94952
PWYLLLLLGHCVGLY	HHATL	116	Q9HCP6
RGFWLTHHLYILLYA	DUOX2	1216	Q9NRD8
LYHSLLEWFHPLYLL	FUCA1	181	P04066
LPYQLAQLLYLAFLW	GPR152	251	Q8TDT2
SLPLRIFYYLNHDWP	GPR174	71	Q9BXC1
LPLWLHKFFPYILLL	PANX1	101	Q96RD7
RWHQALYLLEFFLPL	OXER1	251	Q8TDS5
LLHYFVGANYLWLLV	GLP2R	266	O95838
LGKLLRPNHLWGYYL	SPAM1	206	P38567
VHWYPQLLYRLGRLL	IHH	381	Q14623
RYPHLQWLYGALGLA	SLC18A3	351	Q16572
LLLLWPGFFLLHYTG	SLC35F5	371	Q8WV83
LGQRYSLLPFWYTLL	GANAB	701	Q14697
LGLNIPLLFYHLWRY	CNIH2	91	Q6PI25
LGLNVPLLFYHFWRY	CNIH3	91	Q8TBE1
NLRWYLPAAYVLGLI	STEAP4	411	Q687X5
AYYRLLITHLGLPQW	TPGS2	191	Q68CL5
LYWAYGRHAGLPLLA	TLCD3B	211	Q71RH2
PLAARLLYPYLAWLA	TSPO	131	P30536