Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 OTOP2 GRID1 GRID2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

8.79e-0945913117GO:0005216
GeneOntologyMolecularFunctionchannel activity

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 OTOP2 GRID1 GRID2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

6.24e-0852513117GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 OTOP2 GRID1 GRID2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

6.41e-0852613117GO:0022803
GeneOntologyMolecularFunctiongated channel activity

GABRD GABRE CACNA1F CACNA2D1 GRID1 GRID2 RYR1 RYR3 SCN1A SCN10A SCNN1G KCNS2 TRPM8

3.14e-0733413113GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SLC24A5 CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

4.25e-0734313113GO:0005261
GeneOntologyMolecularFunctiontransporter activity

SLC24A5 GABRD GABRE ATP8B3 CACNA1F CACNA2D1 RHBDF2 ABCA13 OTOP2 GRID1 GRID2 ATP8B1 SLC7A7 SLC7A11 ATP10A SLC16A12 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

8.84e-07128913125GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 OTOP2 GRID1 GRID2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

1.73e-0579313117GO:0015075
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN8A SCN9A SCN10A SCNN1G

2.28e-05521315GO:0005272
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN8A SCN9A SCN10A

2.36e-05261314GO:0005248
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 ABCA13 OTOP2 GRID1 GRID2 SLC7A7 SLC7A11 SLC16A12 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

2.74e-05118013121GO:0022857
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRD GABRE GRID1 GRID2 RYR1 RYR3 SCNN1G TRPM8

4.13e-051931318GO:0015276
GeneOntologyMolecularFunctionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

GAPDH GAPDHS

4.27e-0521312GO:0004365
GeneOntologyMolecularFunctionglyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity

GAPDH GAPDHS

4.27e-0521312GO:0043891
GeneOntologyMolecularFunctionligand-gated channel activity

GABRD GABRE GRID1 GRID2 RYR1 RYR3 SCNN1G TRPM8

4.78e-051971318GO:0022834
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC24A5 CACNA1F CACNA2D1 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

5.73e-0546513112GO:0046873
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN8A SCN9A

9.53e-05141313GO:0031402
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

1.36e-0475813115GO:0015318
GeneOntologyMolecularFunctionfloppase activity

ATP8B3 ATP8B1 ATP10A

1.45e-04161313GO:0140328
GeneOntologyMolecularFunctioncalcium channel activity

SLC24A5 CACNA1F CACNA2D1 RYR1 RYR3 TRPM8

2.09e-041291316GO:0005262
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC24A5 CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

2.49e-0462713113GO:0022890
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR3

2.54e-0441312GO:0005219
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC24A5 CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8

4.31e-0466413113GO:0008324
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

SLC24A5 CACNA1F CACNA2D1 RYR1 RYR3 TRPM8

4.87e-041511316GO:0015085
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GABRD GABRE GRID1 GRID2

5.34e-04571314GO:1904315
GeneOntologyMolecularFunctionphosphatidylcholine flippase activity

ATP8B1 ATP10A

6.30e-0461312GO:0140345
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR3

6.30e-0461312GO:0048763
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

ERAP2 MMP16 ENPEP

6.42e-04261313GO:0070006
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN8A SCN9A

6.42e-04261313GO:0031420
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GABRD GABRE GRID1 GRID2

6.49e-04601314GO:0099529
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R10 TAS2R19 TAS2R30

7.19e-04271313GO:0033038
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP8B3 ATP8B1 ATP10A

8.02e-04281313GO:0140326
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GABRD GABRE GRID1 GRID2

8.79e-04651314GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GABRD GABRE GRID1 GRID2

8.79e-04651314GO:0022824
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC24A5 SCN1A SCN8A SCN9A SCN10A SCNN1G

9.34e-041711316GO:0015081
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR3 TRPM8

1.08e-03311313GO:0099604
GeneOntologyMolecularFunctionmetalloexopeptidase activity

CPB2 ERAP2 MMP16 ENPEP

1.16e-03701314GO:0008235
GeneOntologyMolecularFunctionphosphatidylcholine floppase activity

ATP8B1 ATP10A

1.17e-0381312GO:0090554
GeneOntologyMolecularFunctionhistone H3K9 monomethyltransferase activity

MECOM SETD5

1.17e-0381312GO:0140948
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1F CACNA2D1 RYR1 SCN1A SCN10A KCNS2

1.29e-031821316GO:0005244
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R10 TAS2R19 TAS2R30

1.30e-03331313GO:0008527
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1F CACNA2D1 RYR1 SCN1A SCN10A KCNS2

1.36e-031841316GO:0022832
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP8B3 ATP8B1

1.49e-0391312GO:0090556
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GABRD GABRE GRID1 GRID2

1.50e-03751314GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GABRD GABRE GRID1 GRID2

1.65e-03771314GO:0005230
GeneOntologyMolecularFunctionhistone H3K9me2 methyltransferase activity

MECOM SETD5

1.86e-03101312GO:0140947
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase activity

PIK3C2B PIK3C3

2.26e-03111312GO:0016303
GeneOntologyMolecularFunctionaminopeptidase activity

ERAP2 MMP16 ENPEP

2.81e-03431313GO:0004177
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

MECOM SETD5

3.18e-03131312GO:0046974
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1F CACNA2D1 RYR1

3.41e-03461313GO:0005245
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP8B1 ATP10A

3.69e-03141312GO:0140333
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GABRD GABRE GRID1 GRID2

4.27e-031001314GO:0030594
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP8B3 ATP8B1 ATP10A

4.57e-03511313GO:0140303
GeneOntologyMolecularFunctionprotein phosphatase activator activity

PPP2R5A PPP2R5B

5.45e-03171312GO:0072542
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN10A

5.45e-03171312GO:0099508
GeneOntologyMolecularFunctionflippase activity

ATP8B1 ATP10A

5.45e-03171312GO:0140327
GeneOntologyMolecularFunctionexopeptidase activity

CPB2 ERAP2 MMP16 ENPEP

5.98e-031101314GO:0008238
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR3

6.10e-03181312GO:0015278
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRD GABRE

6.79e-03191312GO:0004890
GeneOntologyMolecularFunctionphosphatidylcholine transporter activity

ATP8B1 ATP10A

7.51e-03201312GO:0008525
GeneOntologyMolecularFunctionphosphatase activator activity

PPP2R5A PPP2R5B

7.51e-03201312GO:0019211
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 RELN OTOP2 GRID1 GRID2 SPG11 ATP8B1 ATP10A RYR1 RYR3 SPTBN4 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13 CNTN1

5.18e-07137413226GO:0006811
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 RELN OTOP2 GRID1 GRID2 ATP8B1 ATP10A RYR1 RYR3 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13

6.02e-07111513223GO:0034220
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA2D1 SCN1A SCN8A SCN9A SCN10A

3.20e-06361325GO:0086010
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

ATP8B1 SPTBN4 LRIG2 SCN1A PGAP1 SCN8A SCN9A SCN10A USH2A

2.31e-052381329GO:0050954
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA2D1 SCN1A SCN8A SCN9A SCN10A

4.81e-05621325GO:0086002
GeneOntologyBiologicalProcesscell junction organization

ROCK2 GABRE CLDN18 RELN SLK MYO1C PCDHGC4 LAMA5 GRID1 GRID2 SPG11 SLC7A11 LRIT3 CLDN1 SPTBN4 SETD5 C1QC SEMA4A

4.95e-0597413218GO:0034330
GeneOntologyBiologicalProcessmetal ion transport

SLC24A5 CACNA1F CACNA2D1 SPG11 RYR1 RYR3 SPTBN4 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13 CNTN1

6.94e-05100013218GO:0030001
GeneOntologyBiologicalProcesssodium ion transport

SLC24A5 SPTBN4 HECW2 SCN1A SCN8A SCN9A SCN10A SCNN1G CNTN1

7.10e-052751329GO:0006814
GeneOntologyBiologicalProcessnerve development

NAGLU ATP8B1 LRIT3 LRIG2 SCN1A SCN8A

7.24e-051091326GO:0021675
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC24A5 GABRD GABRE CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13

8.60e-05101713218GO:0098660
GeneOntologyBiologicalProcessregulation of monoatomic ion transport

GABRE CACNA1F CACNA2D1 RELN SPG11 ATP8B1 SPTBN4 HECW2 GNB5 SCN10A KCNS2 TRIM13 CNTN1

8.65e-0557713213GO:0043269
GeneOntologyBiologicalProcesssynapse organization

ROCK2 GABRE RELN PCDHGC4 LAMA5 GRID1 GRID2 SPG11 SLC7A11 LRIT3 SPTBN4 SETD5 C1QC SEMA4A

1.29e-0468513214GO:0050808
GeneOntologyBiologicalProcessregulation of secondary metabolite biosynthetic process

SLC24A5 SLC7A11 TYRP1

1.35e-04161323GO:1900376
GeneOntologyBiologicalProcessregulation of melanin biosynthetic process

SLC24A5 SLC7A11 TYRP1

1.35e-04161323GO:0048021
GeneOntologyBiologicalProcessregulation of secondary metabolic process

SLC24A5 SLC7A11 TYRP1

1.35e-04161323GO:0043455
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC24A5 CACNA1F CACNA2D1 OTOP2 SPG11 RYR1 RYR3 SPTBN4 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13 CNTN1

1.44e-04115713219GO:0006812
GeneOntologyBiologicalProcessprotein localization to membrane

ROCK2 RELN MYO1C RHBDF2 TM9SF4 LAMA5 SLC7A11 WDR19 SPTBN4 ACSL3 ARL5B PPP2R5A SEC62 LGI1

1.73e-0470513214GO:0072657
GeneOntologyBiologicalProcesslocalization within membrane

ROCK2 RELN MYO1C RHBDF2 TM9SF4 LAMA5 SPG11 SLC7A11 WDR19 SPTBN4 ACSL3 ARL5B PPP2R5A SEC62 LGI1

1.83e-0479813215GO:0051668
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA2D1 SCN1A SCN8A SCN9A SCN10A

2.42e-04871325GO:0086001
GeneOntologyBiologicalProcessregulation of membrane potential

GABRD GABRE CACNA2D1 RELN GRID1 GRID2 SCN1A SCN8A SCN9A SCN10A TSPAN4 KCNS2

2.55e-0455913212GO:0042391
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC24A5 CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13

2.73e-0492213216GO:0098662
GeneOntologyBiologicalProcesscardiac muscle cell contraction

CACNA2D1 SCN1A SCN8A SCN9A SCN10A

3.29e-04931325GO:0086003
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC24A5 CACNA1F CACNA2D1 OTOP2 RYR1 RYR3 HECW2 SCN1A GNB5 SCN8A SCN9A SCN10A SCNN1G KCNS2 TRPM8 TRIM13

3.46e-0494213216GO:0098655
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC24A5 HECW2 SCN1A SCN8A SCN9A SCN10A SCNN1G

3.90e-042081327GO:0035725
GeneOntologyBiologicalProcesstransposable element silencing by mRNA destabilization

TUT7 PIWIL4

4.01e-0451322GO:0141008
GeneOntologyBiologicalProcessactin filament-based movement

CACNA2D1 MYO1C SCN1A SCN8A SCN9A SCN10A

4.59e-041531326GO:0030048
GeneOntologyCellularComponenttransporter complex

GABRD GABRE ATP8B3 CACNA1F CACNA2D1 GRID2 ATP8B1 ATP10A RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2

4.45e-0755013316GO:1990351
GeneOntologyCellularComponentmonoatomic ion channel complex

GABRD GABRE CACNA1F CACNA2D1 GRID2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2

9.08e-0737813313GO:0034702
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN8A SCN9A SCN10A SCNN1G

1.02e-06291335GO:0034706
GeneOntologyCellularComponentcation channel complex

CACNA1F CACNA2D1 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2

2.69e-0623513310GO:0034703
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN8A SCN9A SCN10A

3.50e-06171334GO:0001518
GeneOntologyCellularComponenttransmembrane transporter complex

GABRD GABRE CACNA1F CACNA2D1 GRID2 RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2

3.01e-0552313313GO:1902495
GeneOntologyCellularComponentaxon initial segment

SPTBN4 SCN1A SCN8A LGI1

3.29e-05291334GO:0043194
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP8B3 ATP8B1 ATP10A

8.71e-05141333GO:1990531
GeneOntologyCellularComponentcilium

CACNA1F DYNC2H1 GRK4 AMBRA1 TTLL7 WDR19 DNAI1 RAB28 IFT88 PIK3C3 PROM2 GAPDHS CFAP57 TAS2R19 TAS2R30 USH2A

1.91e-0489813316GO:0005929
GeneOntologyCellularComponentnode of Ranvier

SPTBN4 SCN1A SCN8A

2.65e-04201333GO:0033268
GeneOntologyCellularComponentZ disc

RYR1 RYR3 PPP2R5A RTL1 SCN1A SCN8A

4.15e-041511336GO:0030018
GeneOntologyCellularComponent9+0 non-motile cilium

CACNA1F GRK4 TTLL7 WDR19 IFT88 USH2A

4.45e-041531336GO:0097731
GeneOntologyCellularComponentstereocilium membrane

MYO1C USH2A

5.93e-0461332GO:0060171
GeneOntologyCellularComponentI band

RYR1 RYR3 PPP2R5A RTL1 SCN1A SCN8A

6.84e-041661336GO:0031674
GeneOntologyCellularComponentpostsynaptic membrane

GABRD GABRE CACNA2D1 GRID1 GRID2 GNB5 SCN8A C1QC CNTN1

1.16e-034051339GO:0045211
GeneOntologyCellularComponentcalcium channel complex

CACNA1F CACNA2D1 RYR1 RYR3

1.21e-03731334GO:0034704
GeneOntologyCellularComponentsynaptic membrane

GABRD GABRE CACNA2D1 GRID1 GRID2 SCN1A GNB5 SCN8A SCN10A C1QC CNTN1

1.27e-0358313311GO:0097060
GeneOntologyCellularComponentjunctional membrane complex

RYR1 RYR3

1.40e-0391332GO:0030314
GeneOntologyCellularComponentnon-motile cilium

CACNA1F GRK4 TTLL7 WDR19 IFT88 USH2A

1.61e-031961336GO:0097730
GeneOntologyCellularComponentstereocilium bundle

MYO1C ATP8B1 IFT88 USH2A

1.63e-03791334GO:0032421
GeneOntologyCellularComponentphotoreceptor cell cilium

CACNA1F GRK4 WDR19 IFT88 USH2A

1.97e-031391335GO:0097733
GeneOntologyCellularComponentmotile cilium

DYNC2H1 WDR19 DNAI1 IFT88 GAPDHS CFAP57 TAS2R19 TAS2R30

1.99e-033551338GO:0031514
GeneOntologyCellularComponentpresynaptic membrane

CACNA2D1 SCN1A GNB5 SCN8A SCN10A C1QC CNTN1

2.00e-032771337GO:0042734
GeneOntologyCellularComponentcell body fiber

SPTBN4 SACS

2.13e-03111332GO:0070852
GeneOntologyCellularComponentglutamatergic synapse

ROCK2 GABRD CACNA2D1 GAPDH LAMA5 GRID1 GRID2 PIK3C3 SCN8A SCN10A C1QC CNTN1 LGI1

2.15e-0381713313GO:0098978
GeneOntologyCellularComponentmain axon

SPTBN4 SCN1A SCN8A LGI1

2.52e-03891334GO:0044304
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

GRID2 GNB5 SCN8A

2.58e-03431333GO:0098688
GeneOntologyCellularComponentcluster of actin-based cell projections

MYO1C ATP8B1 SLC7A11 IFT88 USH2A ENPEP

3.07e-032231336GO:0098862
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1F CACNA2D1 RYR1

3.13e-03461333GO:0005891
GeneOntologyCellularComponentendoplasmic reticulum membrane

ATP8B3 DIPK1C RHBDF2 DOLK ATP10A LRIT3 RYR1 RYR3 ACSL3 KSR1 CEPT1 ERAP2 PGAP1 SEC62 DISP3 TRPM8 TRIM13

3.49e-03129313317GO:0005789
GeneOntologyCellularComponentciliary tip

DYNC2H1 WDR19 IFT88

3.53e-03481333GO:0097542
GeneOntologyCellularComponentphotoreceptor connecting cilium

WDR19 IFT88 USH2A

3.53e-03481333GO:0032391
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

ATP8B3 DIPK1C RHBDF2 DOLK ATP10A LRIT3 RYR1 RYR3 ACSL3 KSR1 CEPT1 ERAP2 PGAP1 SEC62 DISP3 TRPM8 TRIM13

3.65e-03129913317GO:0098827
GeneOntologyCellularComponentGABA-ergic synapse

GABRD GABRE CACNA2D1 GRID1 PIK3C3

4.01e-031641335GO:0098982
HumanPhenoFocal clonic seizure

CACNA2D1 RELN SCN1A SCN8A SCN9A LGI1

6.39e-0642586HP:0002266
HumanPhenoFocal automatism seizure

RELN SCN1A SCN8A LGI1

7.00e-0612584HP:0032898
MousePhenoabnormal hair shaft melanin granule shape

SLC24A5 RHBDF2 LYST

5.14e-0731133MP:0009273
MousePhenoabnormal hair follicle morphology

RHBDF2 DSG3 TM9SF4 LAMA5 LYST RYR1 KSR1 PPP2R5A

2.62e-051481138MP:0000377
MousePhenoabnormal posture

RELN MECOM GRID2 RYR1 SPTBN4 LRIG2 SCN1A SCN8A SCN10A CNTN1

2.71e-0524311310MP:0001504
MousePhenoabnormal cerebellar granule cell morphology

GRID2 LYST SCN8A CNTN1 LGI1

2.98e-05451135MP:0004098
MousePhenoabnormal pilosebaceous unit morphology

SLC24A5 RHBDF2 DSG3 TM9SF4 LAMA5 LYST RYR1 KSR1 PPP2R5A

4.21e-052051139MP:0030572
MousePhenoPurkinje cell degeneration

RELN NAGLU GRID2 SPG11 SACS SCN8A

4.84e-05811136MP:0000876
MousePhenoabnormal brain development

RELN SLK DYNC2H1 LAMA5 AMBRA1 MECOM GRID2 SLC7A7 SFMBT2 DNAI1 IFT88 PGAP1 SCN8A EML1 CFAP57 LGI1

5.26e-0563811316MP:0000913
MousePhenoabnormal cerebellar granule layer morphology

RELN GRID2 LYST SCN8A CNTN1 LGI1

6.35e-05851136MP:0000886
MousePhenoneurodegeneration

CACNA1F RELN NAGLU GRID1 GRID2 SPG11 ATP8B1 SPTBN4 RAB28 SACS SCN8A USH2A LGI1

1.02e-0446811313MP:0002229
MousePhenoabnormal behavioral response to anesthetic

GABRD GABRE SCN8A

1.07e-04121133MP:0009777
MousePhenohearing/vestibular/ear phenotype

SLC24A5 MYO1C NAGLU LAMA5 MECOM GRID1 GRID2 ATP8B1 SLC7A11 LYST WDR19 SPTBN4 LRIG2 TYRP1 IFT88 SETD5 PGAP1 SCN8A USH2A

1.09e-0490511319MP:0005377
MousePhenomuscle spasm

RELN GRID2 RYR1 SCN8A EML1

1.21e-04601135MP:0000743
MousePhenoabnormal coat appearance

SLC24A5 RELN RHBDF2 DSG3 NAGLU SLC7A11 LYST CLDN1 LRIG2 TYRP1 KSR1 RAB28 PPP2R5A IFT88 SETD5 SEC62 EML1

1.54e-0477411317MP:0001510
MousePhenomuscle twitch

RELN GRID2 RYR1 SCN8A EML1

1.65e-04641135MP:0009046
MousePhenoabsence seizures

GABRD SCN1A SCN8A LGI1

1.75e-04351134MP:0003216
MousePhenodecreased Purkinje cell number

RELN NAGLU GRID2 LYST SCN8A

2.05e-04671135MP:0000880
MousePhenoabnormal hair shaft melanin granule morphology

SLC24A5 RHBDF2 LYST

2.18e-04151133MP:0008731
MousePhenoabnormal Purkinje cell number

RELN NAGLU GRID2 LYST SCN8A

2.35e-04691135MP:0000878
MousePhenoabnormal Purkinje cell morphology

RELN NAGLU GRID2 SPG11 LYST SACS SCN8A CNTN1

2.48e-042041138MP:0000877
MousePhenoabnormal sensory capabilities/reflexes/nociception

SLC24A5 CACNA2D1 RELN DOLK MECOM GRID2 SPG11 ATP8B1 SLC7A7 LYST RYR1 GDE1 SPTBN4 KLHDC1 SACS SETD5 SCN1A SCN8A SCN9A SCN10A C1QC TRPM8 EML1 MMP16 ENPEP

2.79e-04148611325MP:0002067
MousePhenoabnormal cerebellar layer morphology

RELN NAGLU GRID2 SPG11 LYST SACS SCN8A CNTN1 LGI1

2.80e-042631139MP:0009956
MousePhenononconvulsive seizures

GABRD SCN1A SCN8A LGI1

2.96e-04401134MP:0000948
MousePhenoneuron degeneration

CACNA1F RELN NAGLU GRID1 GRID2 SPG11 ATP8B1 RAB28 SACS SCN8A USH2A

3.22e-0439111311MP:0003224
MousePhenoabnormal hair shaft morphology

SLC24A5 RHBDF2 DSG3 LYST KSR1

3.47e-04751135MP:0003809
MousePhenoabnormal ciliary body pigmentation

SLC24A5 LYST

3.85e-0441132MP:0005101
MousePhenoabnormal skin adnexa morphology

SLC24A5 RELN RHBDF2 DSG3 TM9SF4 NAGLU LAMA5 SLC7A11 LYST CLDN1 RYR1 LRIG2 TYRP1 KSR1 RAB28 PPP2R5A IFT88 SETD5 PROM2 SEC62 C1QC EML1 TRIM13

3.92e-04134111323MP:0010678
MousePhenoabnormal cerebellar Purkinje cell layer

RELN NAGLU GRID2 SPG11 LYST SACS SCN8A CNTN1

4.11e-042201138MP:0000875
MousePhenoabnormal ear morphology

SLC24A5 NAGLU LAMA5 MECOM GRID1 ATP8B1 LYST WDR19 TYRP1 IFT88 PGAP1 USH2A

4.13e-0447011312MP:0002102
MousePhenoimpaired balance

RELN GRID2 LYST SPTBN4 SACS SCN8A

4.41e-041211136MP:0001525
MousePhenoabnormal coat/ hair morphology

SLC24A5 RELN RHBDF2 DSG3 NAGLU SLC7A11 LYST CLDN1 LRIG2 TYRP1 KSR1 RAB28 PPP2R5A IFT88 SETD5 SEC62 EML1

4.86e-0485411317MP:0000367
MousePhenoabnormal eye electrophysiology

CACNA1F RELN NAGLU LRIT3 SCN8A EML1 SEMA4A USH2A

5.21e-042281138MP:0005551
MousePhenoabnormal hindbrain morphology

RELN NAGLU AMBRA1 GRID2 SPG11 LYST SPTBN4 SACS SETD5 SCN8A CNTN1 LGI1

5.46e-0448511312MP:0000841
MousePhenoabnormal truncus arteriosus septation

LAMA5 MECOM TGFBR3 IFT88 SETD5

5.87e-04841135MP:0010454
MousePhenoimpaired behavioral response to anesthetic

GABRD GABRE

6.37e-0451132MP:0009778
DomainIon_trans_dom

CACNA1F RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A KCNS2 TRPM8

1.02e-071141309IPR005821
DomainIon_trans

CACNA1F RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A KCNS2 TRPM8

1.02e-071141309PF00520
DomainNa_channel_asu

SCN1A SCN8A SCN9A SCN10A

4.56e-07101304IPR001696
DomainNa_trans_assoc

SCN1A SCN8A SCN9A SCN10A

4.56e-07101304IPR010526
DomainNa_trans_assoc

SCN1A SCN8A SCN9A SCN10A

4.56e-07101304PF06512
DomainChannel_four-helix_dom

CACNA1F SCN1A SCN8A SCN9A SCN10A KCNS2

2.75e-06571306IPR027359
Domain-

CACNA1F SCN1A SCN8A SCN9A SCN10A KCNS2

2.75e-065713061.20.120.350
DomainNa_trans_cytopl

SCN1A SCN8A SCN9A

6.49e-0661303PF11933
DomainNa_trans_cytopl

SCN1A SCN8A SCN9A

6.49e-0661303IPR024583
DomainIQ_motif_EF-hand-BS

IQCH MYO1C SCN1A SCN8A SCN9A SCN10A

3.91e-05901306IPR000048
DomainIQ

IQCH MYO1C SCN1A SCN8A SCN9A SCN10A

4.70e-05931306PS50096
DomainGp_dh_C

GAPDH GAPDHS

4.81e-0521302PF02800
DomainGlycerAld_3-P_DH_AS

GAPDH GAPDHS

4.81e-0521302IPR020830
DomainGlycerAld/Erythrose_P_DH

GAPDH GAPDHS

4.81e-0521302IPR020831
DomainGlycerAld_3-P_DH_NAD(P)-bd

GAPDH GAPDHS

4.81e-0521302IPR020828
DomainGlycerAld_3-P_DH_cat

GAPDH GAPDHS

4.81e-0521302IPR020829
DomainGAPDH

GAPDH GAPDHS

4.81e-0521302PS00071
DomainGp_dh_N

GAPDH GAPDHS

4.81e-0521302SM00846
DomainGlyceraldehyde-3-P_DH_1

GAPDH GAPDHS

4.81e-0521302IPR006424
DomainGp_dh_N

GAPDH GAPDHS

4.81e-0521302PF00044
DomainP_typ_ATPase_c

ATP8B3 ATP8B1 ATP10A

1.13e-04141303IPR032630
DomainP-type_ATPase_N

ATP8B3 ATP8B1 ATP10A

1.13e-04141303IPR032631
DomainP-type_ATPase_IV

ATP8B3 ATP8B1 ATP10A

1.13e-04141303IPR006539
DomainPhoLip_ATPase_C

ATP8B3 ATP8B1 ATP10A

1.13e-04141303PF16212
DomainPhoLip_ATPase_N

ATP8B3 ATP8B1 ATP10A

1.13e-04141303PF16209
DomainIQ

MYO1C SCN1A SCN8A SCN9A SCN10A

1.36e-04711305PF00612
DomainRyanodine_rcpt

RYR1 RYR3

1.44e-0431302IPR003032
DomainRyanrecept_TM4-6

RYR1 RYR3

1.44e-0431302IPR009460
DomainRyR

RYR1 RYR3

1.44e-0431302PF02026
DomainRR_TM4-6

RYR1 RYR3

1.44e-0431302PF06459
DomainRyan_recept

RYR1 RYR3

1.44e-0431302IPR013333
DomainIQ

IQCH MYO1C SCN1A SCN8A SCN9A

2.54e-04811305SM00015
DomainPP2A_B56

PPP2R5A PPP2R5B

4.74e-0451302IPR002554
DomainB56

PPP2R5A PPP2R5B

4.74e-0451302PF01603
DomainRIH_assoc-dom

RYR1 RYR3

7.08e-0461302IPR013662
DomainIns145_P3_rec

RYR1 RYR3

7.08e-0461302PF08709
DomainRIH_assoc

RYR1 RYR3

7.08e-0461302PF08454
DomainRIH_dom

RYR1 RYR3

7.08e-0461302IPR000699
DomainIns145_P3_rcpt

RYR1 RYR3

7.08e-0461302IPR014821
DomainRyanodine_recept-rel

RYR1 RYR3

7.08e-0461302IPR015925
Domain-

RYR1 RYR3

7.08e-04613021.25.10.30
DomainRYDR_ITPR

RYR1 RYR3

7.08e-0461302PF01365
DomainPIP49_C

DIPK1C DIPK2A

7.08e-0461302PF12260
DomainFAM69_kinase_dom

DIPK1C DIPK2A

7.08e-0461302IPR022049
DomainTAS2R

TAS2R10 TAS2R19 TAS2R30

7.62e-04261303PF05296
DomainT2R

TAS2R10 TAS2R19 TAS2R30

7.62e-04261303IPR007960
DomainERAP1-like_C_dom

ERAP2 ENPEP

1.31e-0381302IPR024571
DomainPI3K_C2

PIK3C2B PIK3C3

1.31e-0381302SM00142
DomainPI3K_C2_dom

PIK3C2B PIK3C3

1.31e-0381302IPR002420
DomainERAP1_C

ERAP2 ENPEP

1.31e-0381302PF11838
DomainPI3K_C2

PIK3C2B PIK3C3

1.31e-0381302PF00792
DomainPI3K_C2

PIK3C2B PIK3C3

1.31e-0381302PS51547
Domain-

ATP8B3 ATP8B1 ATP10A

1.41e-033213033.40.1110.10
Domain-

ATP8B3 ATP8B1 ATP10A

1.41e-033213032.70.150.10
DomainPI3Ka

PIK3C2B PIK3C3

1.68e-0391302PF00613
DomainPI3Ka

PIK3C2B PIK3C3

1.68e-0391302SM00145
Domain-

PIK3C2B PIK3C3

1.68e-03913021.25.40.70
DomainATPase_P-typ_cyto_domN

ATP8B3 ATP8B1 ATP10A

1.83e-03351303IPR023299
DomainATPase_P-typ_P_site

ATP8B3 ATP8B1 ATP10A

1.99e-03361303IPR018303
DomainP_typ_ATPase

ATP8B3 ATP8B1 ATP10A

1.99e-03361303IPR001757
DomainATPASE_E1_E2

ATP8B3 ATP8B1 ATP10A

1.99e-03361303PS00154
DomainMIR

RYR1 RYR3

2.09e-03101302PF02815
DomainMIR_motif

RYR1 RYR3

2.09e-03101302IPR016093
DomainPI_Kinase

PIK3C2B PIK3C3

2.09e-03101302IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C2B PIK3C3

2.09e-03101302IPR001263
DomainMIR

RYR1 RYR3

2.09e-03101302PS50919
DomainMIR

RYR1 RYR3

2.09e-03101302SM00472
DomainHydrolase_3

ATP8B3 ATP10A

2.09e-03101302PF08282
DomainPIK_HELICAL

PIK3C2B PIK3C3

2.09e-03101302PS51545
DomainATPase_P-typ_transduc_dom_A

ATP8B3 ATP8B1 ATP10A

2.15e-03371303IPR008250
DomainE1-E2_ATPase

ATP8B3 ATP8B1 ATP10A

2.15e-03371303PF00122
DomainWD40

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

2.26e-032591307PF00400
Domain-

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 SEMA4A CFAP57

2.32e-0333313082.130.10.10
DomainWD40/YVTN_repeat-like_dom

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 SEMA4A CFAP57

2.41e-033351308IPR015943
DomainWD40

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

2.74e-032681307SM00320
DomainWD40_repeat

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

2.97e-032721307IPR001680
DomainPeptidase_M1

ERAP2 ENPEP

3.03e-03121302IPR001930
DomainWD_REPEATS_1

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

3.35e-032781307PS00678
DomainWD_REPEATS_2

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

3.42e-032791307PS50082
DomainWD_REPEATS_REGION

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

3.42e-032791307PS50294
DomainAA_permease_2

SLC7A7 SLC7A11

3.57e-03131302PF13520
DomainPeptidase_M1_N

ERAP2 ENPEP

3.57e-03131302IPR014782
DomainPeptidase_M1

ERAP2 ENPEP

3.57e-03131302PF01433
DomainAA/rel_permease1

SLC7A7 SLC7A11

3.57e-03131302IPR002293
DomainPI3/4_kinase_CS

PIK3C2B PIK3C3

4.76e-03151302IPR018936
DomainWD40_repeat_dom

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

4.80e-032971307IPR017986
Domain-

PIK3C2B PIK3C3

5.41e-031613021.10.1070.11
DomainLaminin_N

LAMA5 USH2A

5.41e-03161302IPR008211
DomainPI3Kc

PIK3C2B PIK3C3

5.41e-03161302SM00146
DomainLamNT

LAMA5 USH2A

5.41e-03161302SM00136
DomainLAMININ_NTER

LAMA5 USH2A

5.41e-03161302PS51117
DomainLaminin_N

LAMA5 USH2A

5.41e-03161302PF00055
DomainGal_mutarotase_SF_dom

MGAM2 LGI1

6.11e-03171302IPR011013
DomainLig_chan-Glu_bd

GRID1 GRID2

6.84e-03181302PF10613
DomainPI3_PI4_kinase

PIK3C2B PIK3C3

6.84e-03181302PF00454
DomainGlu/Gly-bd

GRID1 GRID2

6.84e-03181302IPR019594
DomainLig_chan-Glu_bd

GRID1 GRID2

6.84e-03181302SM00918
DomainPI3_4_KINASE_1

PIK3C2B PIK3C3

6.84e-03181302PS00915
DomainPI3_4_KINASE_2

PIK3C2B PIK3C3

6.84e-03181302PS00916
DomainIontro_rcpt

GRID1 GRID2

6.84e-03181302IPR001320
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN4 SCN1A SCN8A SCN9A SCN10A

2.89e-06311045M877
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R10 SCNN1G TAS2R19 TAS2R30

7.55e-05311044MM15691
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN8A SCN9A SCN10A

8.58e-05321044M27455
PathwayREACTOME_L1CAM_INTERACTIONS

SPTBN4 SCN1A SCN8A SCN9A SCN10A CNTN1

2.70e-041211046M872
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP8B3 ATP8B1 ATP10A RYR1 RYR3 SCNN1G TRPM8

3.22e-041761047MM15718
PathwayWP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION

SCN8A SCN9A SCN10A MMP16

3.60e-04461044M46450
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R10 SCN9A SCNN1G TAS2R30

3.91e-04471044M42524
PathwayREACTOME_CARDIAC_CONDUCTION

RYR1 RYR3 SCN1A SCN8A SCN9A SCN10A

3.97e-041301046M27454
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP8B3 ATP8B1 ATP10A RYR1 RYR3 SCNN1G TRPM8

4.08e-041831047M997
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN8A SCN9A SCN10A SCNN1G

9.52e-1013133515123669
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN8A SCN9A SCN10A CNTN1

3.05e-096133416029194
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN8A SCN9A SCN10A

3.05e-096133423652591
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN8A SCN9A SCN10A

2.54e-089133416382098
Pubmed

Identification of rat EMAP, a delta-glutamate receptor binding protein.

GRID1 GRID2 EML1

5.47e-083133311829466
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1F CACNA2D1 SCN1A SCN8A SCN9A SCN10A SCNN1G KCNS2

6.84e-08139133816985003
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A SCN10A

2.18e-074133322260870
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ROCK2 CACNA2D1 GAPDH TM9SF4 TUT7 NAGLU LAMA5 COLGALT1 SLC7A11 LRP1B GDE1 DIPK2A LRIG2 MRC2 PGAP1 SEC62 TRIM13 CD276

8.03e-0712011331835696571
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN8A SCN10A TRPM8

1.08e-066133323711479
Pubmed

Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice.

RELN GRID2 SCN8A

3.02e-06813332230805
Pubmed

Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration.

RELN GRID2 SCN8A

6.43e-061013331565842
Pubmed

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

OTOP2 GRID2 LYST SCN8A CNTN1

8.64e-0672133525917818
Pubmed

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.

DYNC2H1 WDR19 IFT88

8.82e-0611133322689656
Pubmed

Autotomy behavior correlates with the DRG and spinal expression of sodium channels in inbred mouse strains.

SCN8A CNTN1

1.45e-052133219524556
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

1.45e-052133237901435
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

1.45e-052133226410685
Pubmed

Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.

RYR1 RYR3

1.45e-05213329489997
Pubmed

The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.

RYR1 RYR3

1.45e-052133212640042
Pubmed

Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.

RYR1 RYR3

1.45e-052133214592949
Pubmed

The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.

PTPRB CNTN1

1.45e-05213327628014
Pubmed

Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells.

GAPDH GAPDHS

1.45e-05213321375514
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

1.45e-052133231943325
Pubmed

Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling.

PTPRB CNTN1

1.45e-05213329584610
Pubmed

Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.

RYR1 RYR3

1.45e-05213329799464
Pubmed

The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts.

GAPDH TYRP1

1.45e-05213328270621
Pubmed

Sodium channel slow inactivation interferes with open channel block.

SCN8A SCN9A

1.45e-052133227174182
Pubmed

Glutamate receptors of the delta family are widely expressed in the adult brain.

GRID1 GRID2

1.45e-052133225001082
Pubmed

TYRP1 mRNA goes fishing for miRNAs in melanoma.

GDE1 TYRP1

1.45e-052133229087386
Pubmed

Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.

RYR1 RYR3

1.45e-052133217118445
Pubmed

Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene.

GAPDH GAPDHS

1.45e-05213323170585
Pubmed

RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.

RYR1 RYR3

1.45e-052133211500519
Pubmed

Mutagenic insertion and chromosome engineering resource (MICER).

LRP1B PGAP1

1.45e-052133215235602
Pubmed

Thrombin-activatable fibrinolysis inhibitor antigen and TAFI activity in patients with APC resistance caused by factor V Leiden mutation.

CPB2 F5

1.45e-052133212165290
Pubmed

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

SCN9A SCN10A

1.45e-052133216111501
Pubmed

Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.

RYR1 RYR3

1.45e-052133212565913
Pubmed

Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.

RYR1 RYR3

1.45e-05213329192302
Pubmed

Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.

GRID1 GRID2

1.45e-052133237944084
Pubmed

Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.

RYR1 RYR3

1.45e-05213327556644
Pubmed

Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.

GAPDH GAPDHS

1.45e-052133216832079
Pubmed

Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.

RYR1 RYR3

1.45e-052133215894801
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

1.45e-052133233411788
Pubmed

Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain.

GRID1 GRID2

1.45e-052133231625608
Pubmed

GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.

GRID1 GRID2

1.45e-052133228696429
Pubmed

Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.

RYR1 RYR3

1.45e-05213329817784
Pubmed

Glyceraldehyde-3-phosphate dehydrogenase from human tissues.

GAPDH GAPDHS

1.45e-05213327144574
Pubmed

LINE-1 (L1) lineages in the mouse.

LYST SCN8A

1.45e-052133210742052
Pubmed

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.

GAPDH GAPDHS

1.45e-052133215507493
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

1.45e-052133237665666
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

1.45e-052133217881658
Pubmed

Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+).

GAPDH GAPDHS

1.45e-052133216324157
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP8B3 ATP8B1 ATP10A

1.52e-0513133311015572
Pubmed

Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.

SCN9A SCN10A TRPM8

1.52e-0513133335904071
Pubmed

Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.

TAS2R10 TAS2R19 TAS2R30

1.52e-0513133315938754
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

GABRE RHBDF2 SCAF8 TM9SF4 ATP8B1 ATP10A SFMBT2 GDE1 SPTBN4 RAB28 PTPRB SETD5 PIK3C3 PROM2 ANKAR TSPAN4 MMP16 AFF4

1.57e-0514891331828611215
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ROCK2 DYNC2H1 ATP10A USP20 LRIG2 SACS DSTYK DISP3 KCNS2 CDC5L

2.13e-054931331015368895
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

CACNA2D1 SLK MYO1C GAPDH DSG3 DYNC2H1 NAGLU LAMA5 GRID1 RYR1 TGFBR3 PROM2 SCN10A ENPEP

3.68e-0510161331419056867
Pubmed

[Under hypoxia condition contactin-1 regulates migration of MKN45 cells through RhoA pathway].

ARHGEF1 CNTN1

4.34e-053133225916117
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR3

4.34e-053133218403125
Pubmed

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.

RYR1 RYR3

4.34e-053133211171121
Pubmed

Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses.

GRID1 GRID2

4.34e-053133210234023
Pubmed

The cell and molecular basis of mechanical, cold, and inflammatory pain.

SCN9A SCN10A

4.34e-053133218669863
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN9A

4.34e-053133233895391
Pubmed

α2δ1-mediated maladaptive sensory plasticity disrupts adipose tissue homeostasis following spinal cord injury.

CACNA2D1 SCN10A

4.34e-053133238663398
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR3

4.34e-05313327876312
Pubmed

Sodium channels and mammalian sensory mechanotransduction.

SCN9A SCN10A

4.34e-053133222449024
Pubmed

Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.

SCN9A SCN10A

4.34e-053133222875917
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SPTBN4 SCN8A

4.34e-053133216033895
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

GAPDH SCN1A

4.34e-053133227816501
Pubmed

Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.

SCN9A SCN10A

4.34e-053133238999942
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR3

4.34e-053133222948152
Pubmed

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.

SCN8A CNTN1

4.34e-053133220133873
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR3

4.34e-053133210788707
Pubmed

Autosomal Dominant Epilepsy with Auditory Features

RELN LGI1

4.34e-053133220301709
Pubmed

Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain.

SCN8A SCN10A

4.34e-053133229497094
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR3

4.34e-05313327621815
Pubmed

Teleost B7 expressed on monocytes regulates T cell responses.

ICOSLG CD276

4.34e-053133219454675
Pubmed

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

SCN1A SCN8A

4.34e-053133226182346
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR3

4.34e-053133210473538
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

SCN1A SCN8A

4.34e-053133231054517
Pubmed

[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier.

SPTBN4 SCN8A

4.34e-053133211807096
Pubmed

Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.

RYR1 RYR3

4.34e-053133218313230
Pubmed

Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism.

CPB2 F5

4.34e-053133212368162
Pubmed

Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity.

SCN10A TRPM8

4.34e-053133232277850
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR3

4.34e-053133218434746
Pubmed

Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia.

CPB2 F5

4.34e-053133219195685
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR3

4.34e-05313329204703
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN9A SCN10A

4.34e-053133219699781
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR3

4.34e-053133221881589
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN8A

4.34e-053133232845893
Pubmed

A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells.

DYNC2H1 IFT88

4.34e-053133212802074
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR3

4.34e-053133212213830
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN8A

4.34e-053133228518218
Pubmed

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.

SCN9A SCN10A

4.34e-053133228074005
Pubmed

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

SCN1A SCN8A

4.34e-053133224704313
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR3

4.34e-05313329242641
Pubmed

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.

SCN9A SCN10A

4.34e-053133215314237
Pubmed

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

SCN1A SCN8A

4.34e-053133228117367
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN8A

4.34e-053133217928448
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR3

4.34e-053133225239916
Pubmed

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

SCN9A SCN10A

4.34e-053133230554136
InteractionSCN11A interactions

SCN1A SCN8A SCN9A SCN10A

2.20e-06151314int:SCN11A
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN8A SCN9A SCN10A

9.61e-0899741203
GeneFamilyGlutamate ionotropic receptor delta type subunits

GRID1 GRID2

2.85e-0529721202
GeneFamilyATPase phospholipid transporting

ATP8B3 ATP8B1 ATP10A

6.50e-05159731210
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR3

8.52e-053972287
GeneFamilyWD repeat domain containing

AMBRA1 LYST WDR19 DNAI1 GNB5 EML1 CFAP57

5.25e-04262977362
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C2B PIK3C3

7.81e-048972831
GeneFamilyTaste 2 receptors

TAS2R10 TAS2R19 TAS2R30

1.19e-03399731162
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R5A PPP2R5B

2.86e-0315972696
GeneFamilyAminopeptidases|CD molecules

ERAP2 ENPEP

3.68e-0317972104
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRD GABRE

4.59e-0319972563
CoexpressionAtlasdev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k-means-cluster#3_top-relative-expression-ranked_1000

CACNA2D1 RYR3 PGAP1 SCN9A DISP3 MMP16 CNTN1 LGI1

3.33e-052021298gudmap_dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k3_1000
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#5_top-relative-expression-ranked_200

CPB2 SCN8A QARS1

5.99e-05131293gudmap_developingKidney_e13.5_podocyte cells_200_k5
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_200

RELN MECOM ST8SIA1 SLC7A7 PCDH20 CLDN1

7.69e-051161296gudmap_developingKidney_e15.5_Peripheral blastema_200_k2
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_1000

RELN MECOM ST8SIA1 SLC7A7 OLFML3 PCDH20 CLDN1 SCN1A

9.36e-052341298gudmap_developingKidney_e15.5_Peripheral blastema_1000_k2
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_200

CACNA2D1 RELN MECOM ST8SIA1 SLC7A7 PCDH20 CLDN1

9.84e-051751297gudmap_developingKidney_e15.5_Peripheral blastema_200
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29965_k-means-cluster#3_top-relative-expression-ranked_500

RELN ST8SIA1 SLC7A7

1.16e-04161293gudmap_developingKidney_e15.5_Endothelial cells_500_k3
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F RELN ABCA13 GRID1 LRP1B RYR3 SCN9A DISP3 USH2A CNTN1

2.24e-10184133102cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F RELN ABCA13 GRID1 LRP1B RYR3 SCN9A DISP3 USH2A CNTN1

2.24e-1018413310ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F RELN ABCA13 GRID1 LRP1B RYR3 SCN9A DISP3 USH2A CNTN1

2.24e-10184133102b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 USP29 F5 LRP1B SFMBT2 ANKAR SCN9A SCN10A USH2A

1.51e-091621339bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 USP29 LRP1B SCN1A ANKAR SCN9A SCN10A USH2A

1.34e-08145133896712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B3 DIPK1C CACNA2D1 IQCH ST8SIA1 SCN9A SCN10A CFAP57

2.61e-081581338f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B3 DIPK1C CACNA2D1 IQCH ST8SIA1 SCN9A SCN10A CFAP57

2.61e-0815813388c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ATP8B1 F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.33e-0618313373c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ATP8B1 F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.33e-0618313379c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ATP8B1 F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.38e-0618413377294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM F5 SLC7A11 LRP1B PTPRB PIK3C2B MMP16

1.48e-0618613372d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRID2 F5 LRP1B LYST PTPRB PGAP1 MMP16

1.48e-06186133792092f11ecce22c14f244e42c499af0822977e6f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN TGFBR3 PTPRB PIK3C2B HECW2 EML1

1.76e-061911337f663131a4810584c5854bd64ee7991a237b7707f
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8B1 F5 LRP1B SFMBT2 PTPRB PGAP1 MMP16

1.83e-06192133781baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM ATP8B1 SFMBT2 PPP2R5A PTPRB HECW2 MMP16

1.89e-0619313376e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM ATP8B1 SFMBT2 PPP2R5A PTPRB PIK3C2B HECW2

1.89e-061931337af5108260783e69a7d67896c5bf64f862525926d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM ATP8B1 SFMBT2 PTPRB PIK3C2B HECW2 MMP16

1.96e-0619413370b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN TGFBR3 PTPRB PIK3C2B HECW2 EML1

1.96e-061941337b490fffc94f005dff9a34ce34d80ca776e3a1387
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN TGFBR3 PTPRB PIK3C2B HECW2 EML1

1.96e-061941337fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLDN18 CACNA2D1 DOLK GRID2 PCDH20 SCN9A CNTN1

2.17e-061971337b8dc192fc98428bbb701cc2ea57fc8ad93397785
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DSG3 ABCA13 LAMA5 CLDN1 KSR1 PROM2 SCNN1G

2.24e-06198133719d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RHBDF2 COLGALT1 SLC7A7 RYR1 SCN9A C1QC NCKAP1L

2.32e-0619913379545ac59c8d75f5747dff86cb511a149dc103b31
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid-Microglia|GW23 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 SFMBT2 RYR1 C1QC NCKAP1L

2.32e-0619913374ddfbcaa8054b69b3398d8c0d5fab8ae94805cb9
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid|GW23 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 SFMBT2 RYR1 C1QC NCKAP1L

2.32e-0619913373ba48a4715d5e9387650aa97e0c5d7f7897bf380
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP29 PIWIL4 GRID2 SCN8A SCN9A DISP3

3.57e-0613713364dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP29 PIWIL4 GRID2 SCN8A SCN9A DISP3

3.57e-061371336c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCellSevere-Myeloid-Mast-|Severe / Condition, Lineage, Cell class and cell subclass

SLC24A5 CACNA2D1 ST8SIA1 LRP1B PTPRB TRPM8

4.95e-061451336ce307d45425a5191882078f049f85477eec40b69
ToppCellSevere-Myeloid-Mast|Severe / Condition, Lineage, Cell class and cell subclass

SLC24A5 CACNA2D1 ST8SIA1 LRP1B PTPRB TRPM8

4.95e-061451336e0bfd2ffdbd6c197ef0a04e983396ebd87ef7127
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

RELN ABCA13 GRID2 SCN1A MMP16 USH2A

5.15e-061461336c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

7.25e-06155133690e629681a72baacc7981b82883866a487638dbc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

7.25e-061551336e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

7.25e-0615513365a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA5 LRP1B SLC16A12 CLDN1 SCNN1G CNTN1

8.09e-061581336d78e7e52657dc094430291fec07e9c298be9e584
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 LRP1B RYR3 SCN9A TRPM8 USH2A

1.19e-05169133612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAPDH PIWIL4 ST8SIA1 OLFML3 TSPAN4 C1QC

1.23e-051701336b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN PTPRB HECW2 DISP3 EML1

1.31e-051721336c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SFMBT2 SLC16A12 RYR3 ACSL3 BCL2L13

1.36e-0517313369dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

F5 ATP10A RYR3 TGFBR3 ENPEP CNTN1

1.45e-051751336a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA5 MECOM SLC16A12 CLDN1 SCNN1G CNTN1

1.59e-051781336fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellcritical-Lymphoid-NK|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SLC24A5 DIPK1C TYRP1 GAPDHS MMP16 CNTN1

1.70e-0518013365abf778395392244daaec876f306ed7e4f388686
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ICOSLG RHBDF2 DSG3 RYR1 C1QC NCKAP1L

1.75e-051811336090e89b506d945e123e647d08947e9649a65ce7c
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 OLFML3 DIPK2A TGFBR3 MRC2 ENPEP

1.81e-051821336c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 OLFML3 DIPK2A TGFBR3 MRC2 ENPEP

1.81e-051821336dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellNS-critical-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SLC24A5 DIPK1C TYRP1 GAPDHS MMP16 CNTN1

1.81e-051821336dd1c59babf7211362452e3e264009d70004d99f6
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.86e-051831336fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.86e-051831336612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.86e-051831336eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IFITM10 LRP1B ATP10A PCDH20 DIPK2A TYRP1

1.86e-051831336c7e94fe3e7669db9304b249979fef7a69c30a143
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F5 ATP10A SFMBT2 RYR3 TGFBR3 ENPEP

1.86e-0518313367c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRID1 IFITM10 PCDH20 MMP16 CNTN1 CD276

2.17e-0518813367471c194276161422326647f09022e94f3d1640c
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRID1 IFITM10 PCDH20 MMP16 CNTN1 CD276

2.17e-051881336053c251d3ddbeb866f34565aefca4535517b4387
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM F5 PTPRB PIK3C2B DISP3 MMP16

2.24e-051891336c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM F5 PTPRB PIK3C2B DISP3 MMP16

2.24e-051891336b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RYR3 TGFBR3 PTPRB PIK3C2B EML1

2.30e-051901336656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATP8B1 LYST TGFBR3 PTPRB PIK3C2B HECW2

2.30e-0519013361caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ST8SIA1 LRP1B OLFML3 SFMBT2 TGFBR3 ENPEP

2.30e-0519013367986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM F5 PTPRB PIK3C2B DISP3 MMP16

2.30e-051901336aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellhuman_hepatoblastoma-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

GABRD GABRE SFMBT2 PTPRB HECW2 MMP16

2.30e-0519013368d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ROCK2 LAMA5 MECOM SLC16A12 PTPRB ENPEP

2.30e-051901336a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

ABCA13 MECOM AGR3 RYR3 DNAI1 CFAP57

2.37e-051911336ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ST8SIA1 LRP1B OLFML3 SFMBT2 ENPEP CNTN1

2.37e-051911336fa380a8752de158974b2ae5e741573439719cc0d
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM F5 PTPRB PIK3C2B DISP3 MMP16

2.37e-0519113364b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

ABCA13 MECOM AGR3 RYR3 DNAI1 CFAP57

2.37e-0519113366228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1B SFMBT2 TGFBR3 PTPRB PIK3C2B MMP16

2.44e-05192133652acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8B1 SFMBT2 PTPRB PIK3C2B HECW2 MMP16

2.44e-0519213360aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MECOM SFMBT2 PPP2R5A PTPRB HECW2 MMP16

2.52e-051931336e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PPP2R5A PTPRB PIK3C2B HECW2 EML1 MMP16

2.52e-05193133602f633b016ab19bfa65bfd0cf32f000549a62148
ToppCelldroplet-Bladder-nan-3m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MECOM ATP8B1 ACSL3 PROM2 PGAP1 TRIM13

2.52e-051931336268925bfe85fb94a93a4ff8fe078d692df888140
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PPP2R5A PTPRB PIK3C2B HECW2 EML1 MMP16

2.52e-0519313365122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLDN18 CRISP2 DYNC2H1 AGR3 CPB2 SCN1A

2.52e-051931336bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8B1 F5 LRP1B PTPRB PGAP1 MMP16

2.52e-0519313367261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCA13 F5 LRP1B RYR3 SCN10A LGI1

2.67e-051951336d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCA13 F5 LRP1B RYR3 SCN10A LGI1

2.67e-05195133619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

RELN SFMBT2 TGFBR3 PTPRB HECW2 EML1

2.74e-051961336e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MECOM ST8SIA1 RYR3 TYRP1 GAPDHS

2.80e-051181335e5202fadb3f9d91e56337ddad1666196ec748d87
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MECOM ATP8B1 SLC7A11 ATP10A PTPRB HECW2

2.82e-051971336a312d9cf4ced949307eb9620be4eed926300b892
ToppCellNon-neuronal-Postmitotic-Microglia-Microglia-8|World / Primary Cells by Cluster

RHBDF2 SLC7A7 OLFML3 SFMBT2 C1QC NCKAP1L

2.82e-05197133693bce9741dec4e60dd470acca87cd4c8074f8876
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

USP29 OLFML3 SLC16A12 MRC2 PGAP1 ENPEP

2.90e-0519813367f728ca6d5317890c6fcde3ce6c10c0970d49a05
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

GABRE LAMA5 MECOM AGR3 PROM2 SCNN1G

2.90e-0519813361fe51f4beca0eef4ff117e6edaa646e35c0f9629
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Myeloid-Microglia|GW26 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 SFMBT2 C1QC NCKAP1L

2.90e-051981336c0d33629438504a1545e07f0e5af2e76f50fd55b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Myeloid|GW26 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 SFMBT2 C1QC NCKAP1L

2.90e-0519813362b93995f66c7352acc25d6c71d025b847881dacd
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DSG3 ABCA13 LAMA5 CLDN1 PGAP1 SCNN1G

2.90e-0519813365374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCellParenchyma_COVID-19-Endothelial-TX-Lymphatic|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

GABRE RELN TGFBR3 PTPRB HECW2 SCN9A

2.99e-05199133688f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRE DSG3 ABCA13 LAMA5 CLDN1 PGAP1

2.99e-05199133694a7867e800df352731796de8c24cba133c29622
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GABRE RELN TGFBR3 PTPRB HECW2 SCN9A

2.99e-05199133664b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GABRE RELN TGFBR3 PTPRB HECW2 SCN9A

2.99e-0519913362b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCellwk_08-11-Hematologic-Myeloid-SPP1+_Mac|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RHBDF2 SLC7A7 SFMBT2 RYR1 C1QC NCKAP1L

2.99e-051991336d94cf750599366061066074e8007d707adf6fc5a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 SFMBT2 RYR1 NCKAP1L

3.07e-0520013360eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 SFMBT2 RYR1 NCKAP1L

3.07e-05200133601d707c4f8ee0daac635b7260937b1baebc6fc23
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ATP8B1 TGFBR3 PPP2R5A PTPRB PGAP1 MMP16

3.07e-0520013367eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial|GW16 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 MRC2 TSPAN4 NCKAP1L

3.07e-05200133625f4c051c2e869481f33c22ad54de97efac444ad
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

RHBDF2 SLC7A7 OLFML3 MRC2 TSPAN4 NCKAP1L

3.07e-052001336da45a85a4667965b24ba824af871157af5b4cd19
ToppCellfacs-Aorta-Heart-3m-Myeloid-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM169 PROM2 SCN1A C1QC USH2A

6.13e-05139133522a769d5195ed761ef333ef542746e1ba617a698
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

RELN GRID2 RYR1 PTPRB USH2A

6.13e-05139133564c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCellfacs-Aorta-Heart-3m-Myeloid-professional_antigen_presenting_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM169 PROM2 SCN1A C1QC USH2A

6.13e-051391335292533e04178dd36d57377562077f9deb2cb9746
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN GRID2 LRP1B RYR1 USH2A

8.79e-0515013350205318a870e091add66ee4305747dda9f51510d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 LRP1B SCNN1G TRPM8 LGI1

9.64e-0515313359b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 IFITM10 SLC7A11 LRIT3 SCN10A

9.64e-051531335cb144b8c487286384b47fdff88ff98fcf0508899
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA5 MECOM SLC16A12 CLDN1 CNTN1

1.09e-0415713356ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 MECOM SCNN1G TRPM8 LGI1

1.09e-0415713352c5295043611bac7dfa4aef2146681bce4a33a8f
ComputationalNeighborhood of IFNA1

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR1 RYR3 PTPRB LGI1

1.77e-04205838MORF_IFNA1
ComputationalNeighborhood of CAMK4

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR1 RYR3 PPP2R5B PTPRB LGI1

3.82e-04290839MORF_CAMK4
ComputationalNeighborhood of MLLT10

CACNA2D1 CPB2 ATP8B1 ST8SIA1 USP20 RYR3 PPP2R5B PTPRB LGI1

5.14e-04302839MORF_MLLT10
ComputationalNeighborhood of MLF1

CRISP2 GRK4 IFT88 GAPDHS TRIM13

5.47e-0487835GNF2_MLF1
ComputationalNeighborhood of PTPRB

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR3 PPP2R5B PTPRB LGI1

7.44e-04254838MORF_PTPRB
ComputationalNeighborhood of RAD51L3

CACNA2D1 CPB2 ATP8B1 ST8SIA1 USP20 RYR1 RYR3 PPP2R5B PTPRB LGI1

7.60e-043878310MORF_RAD51L3
ComputationalNeighborhood of MAGEA8

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR1 RYR3 PTPRB LGI1

8.66e-04260838MORF_MAGEA8
ComputationalNeighborhood of SUPT3H

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR1 RYR3 PPP2R5B PTPRB LGI1

9.27e-04328839MORF_SUPT3H
ComputationalNeighborhood of ATF2

CACNA2D1 CPB2 ATP8B1 ST8SIA1 USP20 RYR3 PPP2R5B PTPRB LGI1

9.68e-04330839MORF_ATF2
ComputationalNeighborhood of MDM2

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR3 PPP2R5B PTPRB LGI1

1.36e-03279838MORF_MDM2
ComputationalNeighborhood of FSHR

CACNA2D1 CPB2 ATP8B1 ST8SIA1 RYR1 RYR3 PTPRB LGI1

1.36e-03279838MORF_FSHR
Druggabapentin

GABRD GABRE CACNA1F CACNA2D1 GRID1 GRID2 RYR1 RYR3 SCN9A SCN10A SCNN1G

4.33e-0916913211CID000003446
Drugriluzole

GABRD GABRE CACNA1F CACNA2D1 GRID1 GRID2 RYR1 RYR3 SCN9A SCN10A SCNN1G

5.88e-0917413211CID000005070
DrugT2755

CACNA2D1 DSG3 GRID1 GRID2 SCN9A SCN10A SCNN1G

1.83e-07711327CID000005514
Drugketamine

GABRD GABRE CACNA2D1 GRID1 GRID2 F5 RYR1 SCN9A SCN10A SCNN1G CNTN1

3.85e-0726213211CID000003821
Drugisoflurane

GABRD GABRE ICOSLG CACNA2D1 GRID1 GRID2 RYR1 RYR3 SCN9A SCN10A SCNN1G

7.17e-0727913211CID000003763
Drugisradipine

CACNA1F CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

1.92e-061001327CID000003784
Drugflecainide

CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

3.56e-06711326CID000003355
Drugchloro-m-cresol

CACNA2D1 RYR1 RYR3

3.76e-0661323CID000012008
Druglamotrigine

CACNA1F CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

5.18e-061161327CID000003878
DrugAzumoleno

CACNA2D1 RYR1 RYR3

6.55e-0671323CID000056259
DrugCHEBI:564108

CACNA2D1 RYR1 RYR3

6.55e-0671323CID006400637
Drugspiradoline

LYST SCN9A SCN10A SCNN1G TRIM13

6.88e-06461325CID000005620
Drugbepridil

CACNA1F CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

8.93e-061261327CID000002351
DrugAC1NT1AF

SCN9A SCN10A SCNN1G TRIM13

1.24e-05251324CID005322157
DrugAnisomycin [22862-76-6]; Down 200; 15uM; MCF7; HT_HG-U133A

SLK ARID3A DOLK SLC7A11 SACS PIK3C2B DSTYK MMP16

1.27e-0518513285364_DN
Drugpropofol

GABRD GABRE CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

1.61e-051911328CID000004943
DrugErgocryptine-alpha [511-09-1]; Up 200; 7uM; HL60; HT_HG-U133A

ICOSLG ARID3A DYNC2H1 F5 ATP10A PTPRB MRC2 ENPEP

1.67e-0519213282572_UP
DrugAC1L1MOZ

NAGLU SCN9A SCN10A SCNN1G

1.71e-05271324CID000031958
DrugChlorthalidone [77-36-1]; Up 200; 11.8uM; HL60; HG-U133A

ROCK2 ARID3A MYO1C DOLK AMBRA1 USP20 TSPAN4 CDC5L

2.16e-0519913281581_UP
Druggadolinium

CACNA1F CACNA2D1 ST8SIA1 RYR1 RYR3 SACS GNB5 USH2A

2.16e-051991328CID000023982
Drugprocaine

CACNA1F CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

3.15e-051531327CID000004914
Drugplatensimycin

GAPDH GDE1 PIK3C2B PIK3C3 GAPDHS

3.26e-05631325CID006857724
Drug2-aza-9,10-anthraquinone

GAPDH GAPDHS

3.34e-0521322CID000100650
Drugalpha-cyano-3-hydroxycinnamic acid

GAPDH GAPDHS

3.34e-0521322CID000002101
Drugbeta-(2-furyl)acryloyl phosphate

GAPDH GAPDHS

3.34e-0521322CID006439216
Drug5'-adenylyl (beta,gamma-methylene)diphosphonate

RYR1 RYR3

3.34e-0521322ctd:C005147
Drugalpha-chlorohydrin-1-phosphate

GAPDH GAPDHS

3.34e-0521322CID000208040
DrugSm35

GAPDH GAPDHS

3.34e-0521322CID000486051
Drugtetrahydropentalenolactone

GAPDH GAPDHS

3.34e-0521322CID000190858
Drug1-chloro-3-hydroxyacetone

GAPDH GAPDHS

3.34e-0521322CID000090494
Drug2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone

GAPDH GAPDHS

3.34e-0521322CID005374858
Drug6-chloro-6-deoxyglucitol

GAPDH GAPDHS

3.34e-0521322CID000131735
Drug5-aminoisatin

GAPDH GAPDHS

3.34e-0521322CID011819346
Drug3-bromolactate

GAPDH GAPDHS

3.34e-0521322CID000098978
Drugechinone

GAPDH GAPDHS

3.34e-0521322CID000157629
Drug4-oxonorvaline

GAPDH GAPDHS

3.34e-0521322CID000000423
DrugNSC93767

CACNA2D1 SCN9A SCN10A SCNN1G

3.42e-05321324CID000005658
DrugCHAPS detergent

CACNA2D1 GAPDH LYST RYR1 RYR3 TSPAN4 GAPDHS

3.87e-051581327CID000107670
DrugCNS 1145

CACNA1F CACNA2D1 RYR1 RYR3

3.88e-05331324CID000190902
DrugIHC-64

CACNA1F CACNA2D1 RYR1 RYR3

3.88e-05331324CID000162753
DrugTetracaine

RYR1 SCN9A SCN10A

4.03e-05121323ctd:D013748
Drugglutamate

GABRD GABRE CACNA1F CACNA2D1 RELN GAPDH GRID1 GRID2 SLC7A11 RYR1 RYR3 SCN9A SCNN1G TRPM8 GAPDHS QARS1 ENPEP

4.22e-0596213217CID000000611
DrugADPribulose

GAPDH SPTBN4 GAPDHS

5.22e-05131323CID000197570
Drugbenzocaine

ICOSLG SCN9A SCN10A SCNN1G

6.15e-05371324CID000002337
Drugvalproate

CACNA1F CACNA2D1 RELN PCDHGC4 SFMBT2 RYR1 RYR3 TGFBR3 SCN9A SCNN1G

7.82e-0538113210CID000003121
Druggenistein

ROCK2 GABRD GABRE CACNA1F CACNA2D1 GAPDH DSG3 LAMA5 SLC7A11 OLFML3 CLDN1 USP20 RYR1 RYR3 PIK3C2B PIK3C3 GAPDHS MMP16

8.12e-05111713218CID005280961
DrugFPL 64176

CACNA2D1 RYR1 RYR3

8.24e-05151323CID000003423
DrugNSC7524

CACNA1F CACNA2D1 RYR1 RYR3 SCN9A SCN10A SCNN1G

9.45e-051821327CID000005657
DrugFura-2AM

ROCK2 CACNA2D1 RYR1 RYR3 SACS

9.70e-05791325CID000105091
Drug7-BrMe-12-MeBA

GAPDH GAPDHS

9.97e-0531322CID000027767
Drugsodium perborate

GAPDH GAPDHS

9.97e-0531322CID000517072
Drugcis-diammineplatinum(II

RYR1 RYR3

9.97e-0531322CID000159790
Drug2,4-diaminovaleric acid

GAPDH GAPDHS

9.97e-0531322CID000000063
Drug2-hydroxyheptanoic acid

RYR1 RYR3

9.97e-0531322CID002750949
Drug8N3-cADPR

RYR1 RYR3

9.97e-0531322CID000127713
DrugNSC136036

GAPDH GAPDHS

9.97e-0531322CID000282522
Drugaminodantrolene

RYR1 RYR3

9.97e-0531322CID009570289
Drug2-chloroethyl ethyl sulfone

GAPDH GAPDHS

9.97e-0531322CID000101406
Drug3-chlorolactaldehyde

GAPDH GAPDHS

9.97e-0531322CID000129655
Drug2-hydroxycarbazole

RYR1 RYR3

9.97e-0531322CID000093551
Drug1,1'-diheptyl-4,4'-bipyridinium

RYR1 RYR3

9.97e-0531322CID000080262
Drugflubendiamide

RYR1 RYR3

9.97e-0531322CID011193251
Drugbiotinyl-ADP

GAPDH GAPDHS

9.97e-0531322CID000084080
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR3

9.97e-0531322CID005748312
Drug7-methoxymethyl-12-methylbenz(a)anthracene

GAPDH GAPDHS

9.97e-0531322CID000083361
Drug2-chloroethyl ethyl sulfoxide

GAPDH GAPDHS

9.97e-0531322CID000214273
DrugDicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; PC3; HT_HG-U133A

ICOSLG SLC7A11 CLDN1 RAB28 SCN9A MMP16 AFF4

1.12e-0418713274581_UP
Druganiracetam

MYO1C GRID1 GRID2 LYST TYRP1 KSR1

1.12e-041301326CID000002196
Drugsodium

GABRD GABRE ATP8B3 CACNA2D1 GRID1 GRID2 SLC7A7 SLC7A11 RYR1 RYR3 DIPK2A PTPRB SACS SCN9A SCN10A SCNN1G

1.17e-0494413216CID000000923
Drugmethyl acetimidate

GAPDH DNAI1 GAPDHS

1.22e-04171323CID000026888
DrugApUpG

CPB2 RYR1 ENPEP

1.22e-04171323CID000165128
Druglifarizine

CACNA2D1 SCN9A SCNN1G

1.22e-04171323CID000071336
Drugbaclofen

GABRD GABRE CACNA1F CACNA2D1 GRK4 RYR1 RYR3

1.28e-041911327CID000002284
DrugXeC compound

CACNA2D1 RYR1 RYR3 TYRP1 SEC62

1.30e-04841325CID000005701
DrugMeclozine dihydrochloride [1104-22-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A

SLC7A11 ATP10A TTLL7 WDR19 KSR1 MRC2 SEMA4A

1.32e-0419213275607_UP
DrugIohexol [66108-95-0]; Up 200; 4.8uM; PC3; HT_HG-U133A

ICOSLG CACNA2D1 MYO1C SLC7A11 KSR1 RAB28 DSTYK

1.41e-0419413274643_UP
Druglanthanum

CACNA1F CACNA2D1 NAGLU CLDN1 RYR1 RYR3

1.44e-041361326CID000023926
Drug1H-imidazole hydrochloride

CACNA2D1 GAPDH GAPDHS

1.46e-04181323CID000518985
Drugrotenone; Up 200; 1uM; MCF7; HT_HG-U133A

ROCK2 CACNA2D1 RELN CPB2 LYST TTLL7 SEMA4A

1.55e-0419713275915_UP
DrugGuanadrel sulfate [22195-34-2]; Up 200; 7.6uM; PC3; HT_HG-U133A

CACNA2D1 AMBRA1 CPB2 ATP10A KSR1 MRC2 DSTYK

1.55e-0419713273698_UP
DrugMeclofenoxate hydrochloride [3685-84-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A

GABRD ICOSLG RELN LRP1B EML1 BCL2L13 CNTN1

1.55e-0419713274729_UP
DrugNomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A

CLDN18 CACNA2D1 RELN F5 CLDN1 PPP2R5B CNTN1

1.59e-0419813276525_UP
DrugBetulinic acid [472-15-1]; Up 200; 8.8uM; PC3; HT_HG-U133A

CRISP2 CACNA2D1 ST8SIA1 F5 ATP10A SCN10A USH2A

1.59e-0419813274101_UP
DrugDirithromycin [62013-04-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

ROCK2 ICOSLG ATP10A RYR3 KSR1 PPP2R5B MMP16

1.64e-0419913277446_UP
DrugConvolamine hydrochloride [500-56-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

ROCK2 TM9SF4 LAMA5 USP20 TTLL7 GNB5 MMP16

1.64e-0419913275876_DN
Drugdiprafenone

SCN9A SCN10A SCNN1G

1.72e-04191323CID000071249
Drugindoxacarb

ATP8B1 SCN9A SCN10A SCNN1G

1.87e-04491324CID000107720
Drug2-amino-4-phosphonobutyric acid

CACNA2D1 GRK4 GRID1 GRID2 RYR1

1.89e-04911325CID000002207
DrugA-30

RYR1 RYR3

1.99e-0441322CID003028528
DrugLidocaine

SCN9A SCN10A

1.99e-0441322DB00281
DrugPCB74

RYR1 RYR3

1.99e-0441322CID000036218
DrugAPETx2 protein, Anthopleura elegantissima

SCN8A SCN10A

1.99e-0441322ctd:C501880
Drugoxoammonium tetrafluoroborate

GAPDH GAPDHS

1.99e-0441322CID000151929
Drug3-chlorolactate

GAPDH GAPDHS

1.99e-0441322CID000092899
Drugnatrin

CACNA2D1 RYR1

1.99e-0441322CID000019130
Drug148504-47-6

RYR1 RYR3

1.99e-0441322CID006444275
DrugBastadin 10

RYR1 RYR3

1.99e-0441322CID009589366
DrugSC 38249

RYR1 RYR3

1.99e-0441322CID000134834
DrugAC1L1U7A

RYR1 RYR3

1.99e-0441322CID000035682
Drugadenosine diphosphoribose

GAPDH RYR1 RYR3 TRPM8 GAPDHS

1.99e-04921325CID000030243
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN8A SCN9A SCN10A

7.17e-08101294DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN8A SCN9A SCN10A

7.17e-08101294DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN8A SCN9A SCN10A

1.68e-07121294DOID:0060170 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

GABRD SCN1A SCN9A

6.73e-0691293C3502809
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

1.90e-0521292C4551549
DiseaseNeuralgia, Supraorbital

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0038870
DiseaseNeuralgia

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0027796
DiseaseNeuralgia, Atypical

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0234247
DiseaseNeuralgia, Stump

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0234249
DiseaseNeuralgia, Iliohypogastric Nerve

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0423712
DiseaseNeuralgia, Perineal

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0423711
DiseaseParoxysmal Nerve Pain

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0751373
DiseaseNerve Pain

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0751372
DiseaseNeuralgia, Ilioinguinal

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0751371
DiseaseNeuralgia, Vidian

CACNA2D1 SCN9A SCN10A

4.38e-05161293C0042656
DiseaseAutosomal dominant epilepsy with auditory features

RELN LGI1

5.67e-0531292cv:C1838062
DiseaseB Virus Infection

SCN8A SCN9A

5.67e-0531292C0037140
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR3

5.67e-0531292DOID:3529 (implicated_via_orthology)
DiseasePostherpetic neuralgia

SCN8A SCN9A

5.67e-0531292C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

5.67e-0531292C0019372
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR3

5.67e-0531292DOID:8545 (implicated_via_orthology)
DiseaseEPILEPSY, FAMILIAL TEMPORAL LOBE, 1

RELN LGI1

5.67e-0531292600512
DiseasePrimary Erythermalgia

SCN9A SCN10A

5.67e-0531292C0014805
DiseaseEpilepsy, Familial Temporal Lobe 1

RELN LGI1

5.67e-0531292C4551957
DiseaseEpilepsy, familial temporal lobe, 1

RELN LGI1

5.67e-0531292cv:C4551957
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN9A SCN10A

5.67e-0531292C1833661
DiseaseAutosomal Dominant Lateral Temporal Lobe Epilepsy

RELN LGI1

5.67e-0531292C1838062
Diseaseepilepsy (implicated_via_orthology)

LRP1B SCN1A SCN8A SCN9A SCN10A LGI1

8.42e-051631296DOID:1826 (implicated_via_orthology)
DiseaseJeune thoracic dystrophy

DYNC2H1 WDR19

1.13e-0441292cv:C0265275
Diseasecutaneous melanoma, hair color

SLC24A5 ATP10A TYRP1 DSTYK

1.60e-04621294EFO_0000389, EFO_0003924
DiseaseSudden death

CACNA2D1 SCN10A

1.88e-0451292C0011071
DiseaseColorectal Carcinoma

GAPDH ABCA13 OTOP2 GRID1 GRID2 F5 SACS ARHGEF1 GNB5 SCNN1G CNTN1

2.68e-0470212911C0009402
DiseaseCone-Rod Dystrophy 2

CACNA1F RAB28 SEMA4A

2.74e-04291293C3489532
DiseaseDisorder of eye

SLC24A5 CACNA1F LRIT3 TYRP1 SEMA4A USH2A

3.50e-042121296C0015397
DiseaseCongenital Pain Insensitivity

SCN9A SCN10A

3.93e-0471292C0002768
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN9A SCN10A

3.93e-0471292C0020075
DiseaseAlbinism, Oculocutaneous

SLC24A5 TYRP1

3.93e-0471292C0078918
Diseaseeye colour measurement

SLC24A5 SLC7A7 TYRP1 PIK3C3 DSTYK USH2A

4.06e-042181296EFO_0009764
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

5.22e-0481292C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

5.22e-0481292C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

5.22e-0481292C0338479
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

5.22e-0481292C0751120
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

5.22e-0481292C0438414
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

5.22e-0481292C0393703
DiseaseAutism Spectrum Disorders

RELN DIPK2A SCN1A USH2A

5.37e-04851294C1510586
Diseaseglaucoma

MECOM LRP1B WDR19 DISP3 CDC5L

5.94e-041541295MONDO_0005041
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

6.69e-0491292C0014550
DiseaseInherited neuropathies

SPG11 SACS SCN9A

7.17e-04401293C0598589
Diseasesevere acute respiratory syndrome, COVID-19

ATP8B3 CACNA2D1 RELN GRK4 LRP1B LYST TGFBR3 KSR1

8.05e-044471298EFO_0000694, MONDO_0100096
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

8.34e-04101292C0917800
DiseaseOther specified cardiac arrhythmias

CACNA2D1 SCN10A

1.02e-03111292C0348626
DiseaseJeune thoracic dystrophy

DYNC2H1 WDR19

1.02e-03111292C0265275
DiseaseNodal rhythm disorder

CACNA2D1 SCN10A

1.02e-03111292C0264893
DiseaseEctopic rhythm

CACNA2D1 SCN10A

1.02e-03111292C1399226
DiseaseShortened QT interval

CACNA2D1 SCN10A

1.02e-03111292C0151879
DiseaseCARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)

CACNA2D1 SCN10A

1.02e-03111292C2748542
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

1.02e-03111292C0393702
Diseasesystolic blood pressure change measurement

NAGLU TGFBR3 GAPDHS

1.15e-03471293EFO_0006944
DiseaseNight blindness, congenital stationary, type 1

CACNA1F LRIT3

1.22e-03121292C3501847
DiseaseNight Blindness, Congenital Stationary, Type 1A

CACNA1F LRIT3

1.22e-03121292C3495587
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)

CACNA1F LRIT3

1.22e-03121292C1864877
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B

CACNA1F LRIT3

1.22e-03121292C1850362
DiseaseX-Linked Csnb

CACNA1F LRIT3

1.22e-03121292C3711543
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A

CACNA1F LRIT3

1.22e-03121292C1848172
DiseaseCiliopathies

DYNC2H1 WDR19 SCNN1G USH2A

1.41e-031101294C4277690
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN9A

1.43e-03131292C0751122
DiseaseCone-rod synaptic disorder, congenital nonprogressive

CACNA1F LRIT3

1.43e-03131292C4041558
DiseaseBrugada Syndrome 1

CACNA2D1 SCN10A

1.43e-03131292C4551804
Diseasecortisol measurement, response to corticosteroid, response to synacthen

LRP1B BCL2L13

1.43e-03131292EFO_0005843, EFO_0009175, GO_0031960
DiseaseUveal Melanoma

CACNA2D1 LRP1B GNB5

1.63e-03531293EFO_1000616
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

SLC7A11 LYST

1.92e-03151292DOID:2223 (implicated_via_orthology)
DiseaseSinus Node Dysfunction (disorder)

CACNA2D1 SCN10A

1.92e-03151292C0428908
DiseaseNight blindness, congenital stationary

CACNA1F LRIT3

2.47e-03171292C0339535
Diseaseage at onset, Parkinson disease

DSG3 KLHDC1

2.77e-03181292EFO_0004847, MONDO_0005180
DiseaseHeadache

CACNA2D1 TGFBR3 TRPM8

2.80e-03641293HP_0002315
Diseaseskin pigmentation measurement

SLC24A5 OLFML3 TYRP1 USH2A

3.13e-031371294EFO_0007009
Diseasediet measurement, body mass index

GRID2 LGI1

3.42e-03201292EFO_0004340, EFO_0008111
Diseasealpha-tocopherol measurement

CACNA2D1 USH2A

3.42e-03201292EFO_0007898
Diseasenucleotide measurement

DOLK PTPRB ENPEP

4.06e-03731293EFO_0010513
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN9A

4.14e-03221292DOID:2030 (implicated_via_orthology)
Diseaseotitis media (implicated_via_orthology)

NAGLU MECOM

4.14e-03221292DOID:10754 (implicated_via_orthology)
DiseaseBronchiectasis

DNAI1 SCNN1G

4.14e-03221292C0006267

Protein segments in the cluster

PeptideGeneStartEntry
LEDYSAEYIIQQGGW

BCL2L13

186

Q9BXK5
FQVAERALYFWNNEY

PPP2R5B

371

Q15173
KFVDTDIWNQYLEYQ

ARMT1

81

Q9H993
WDLSYESINYIFASD

ADAL

321

Q6DHV7
YVLFTWDQEAQIYEL

ARHGEF1

726

Q92888
TYSDYLRWESFLQQQ

DISP3

1136

Q9P2K9
AYNQVWEECYSQVLY

CDC5L

656

Q99459
SWNTYYSNTEFIILV

ARL5B

76

Q96KC2
DITWVQTYEEGLFYA

AGR3

41

Q8TD06
TLEKTQFFLEQAYYW

ABCA13

626

Q86UQ4
FIYLGNSVFIDWDVQ

ATP8B3

451

O60423
SSYQGYPEAEVFWQD

CD276

166

Q5ZPR3
FSATANQWEIYDAYV

DNAI1

221

Q9UI46
EYYWDQLNETVFTVH

AMBRA1

1046

Q9C0C7
IQSWYDEILDFVYGV

CRISP2

111

P16562
VEPWKEQFFESYYGQ

ASXL2

366

Q76L83
AQTAYEDWFITLYNV

ATP8B1

976

O43520
FQIGLDTSYWTFVNA

ATP8B1

1086

O43520
LAYYDSNVDLFTWGT

ATP10A

1191

O60312
YVQVTSNFLYATEIW

AFF4

1096

Q9UHB7
DFYEQNSRYQLTLWG

NAGLU

636

P54802
TNYQSFENLEDWYTV

RAB28

96

P51157
FAGYNDYTINVWDVL

GNB5

341

O14775
WDYDFLIYDGVIDNT

IQCH

266

Q86VS3
ERQLYAWDDGYQIVY

OLFML3

381

Q9NRN5
SYGWEILDEFYNVKF

MECOM

121

Q03112
QYENVFIFETGYWLT

ANKAR

256

Q7Z5J8
YEYTLGQAQNLIIFW

HECW2

66

Q9P2P5
YRVWATVNSAAFEYL

CACNA1F

1181

O60840
EYTDNWLAVYFFTSG

DSG3

296

P32926
DYELQQFYEVAVVAW

PCDH20

496

Q8N6Y1
TASEGELSWYNIFLY

PTPRB

1106

P23467
WVDLYLDYVGVVDYQ

LRP1B

386

Q9NZR2
LIFDSGVDLNYSYAW

DOLK

491

Q9UPQ8
WGVNTYVTQVSFTYD

MGAM2

1756

Q2M2H8
WNYETNTLELFKEYQ

CFAP57

416

Q96MR6
NYAFVWDAAVLEYVA

GRID2

736

O43424
AADVYAFGTVWYELQ

KSR1

801

Q8IVT5
FSQEIEYWGINEFFI

KCNS2

101

Q9ULS6
GEQTITTLYTNWYLE

NCKAP1L

781

P55160
AFVSSLIYNWEGEYF

MRC2

566

Q9UBG0
GYSSEDIVYYWSESQ

GABRD

186

O14764
YTIDIIFSQTWYDER

GABRE

116

P78334
VELQYLWVTYNSVAS

LRIT3

81

Q3SXY7
FYRVNYEVATWDSIA

ENPEP

626

Q07075
FYSNATGVWLYVDDQ

LAMA5

3206

O15230
VDLDSGYNAWVSYQL

PCDHGC4

596

Q9Y5F7
DNSVDVYAFGILFWY

DSTYK

826

Q6XUX3
VQYSTDFGVSWNYLV

RELN

2776

P78509
DTALAIIYNLWFGYD

GGTLC3

136

B5MD39
DIQDYFLTGYVWSAV

PIK3C2B

351

O00750
NTVEVDFYGYSLWAV

OTOP2

521

Q7RTS6
EGSRFDLNDVYVYWQ

ICOSLG

41

O75144
LQVGEEVWLAVNDYY

C1QC

211

P02747
EYRNNLENWIGDYFE

DYNC2H1

2136

Q8NCM8
VLTYQGFYDENLEWV

DYNC2H1

2381

Q8NCM8
QYFNSFIDEYIVLWI

CEPT1

361

Q9Y6K0
VVGWTVNTFDEKSYY

GDE1

296

Q9NZC3
EVIEWLGAYYIDTQF

IFT88

621

Q13099
EQYHSLNEIYSWIEF

CPB2

121

Q96IY4
ATAWYGNRIVQEFYD

CLDN1

136

O95832
NWQENPETYEDSFYK

CACNA2D1

751

P54289
AVNYVGEELWSYFNA

DIPK2A

241

Q8NDZ4
LTFVWSFNGYVIDFN

CNTN1

536

Q12860
DTTEVNDYYLWSIFN

IFITM10

146

A6NMD0
LTNLWYTGQITNFEY

LYST

3131

Q99698
TTAGWNYLLEQYELS

ERAP2

801

Q6P179
NYAFLWDVAVVEYAA

GRID1

736

Q9ULK0
YVWGGYVSIEDNEVY

KLHDC1

26

Q8N7A1
FLVSNSGDYEILYWV

EML1

686

O00423
NLVEADYSYWTLAYV

COLGALT1

486

Q8NBJ5
EYQESSYFSQFLQWK

GRK4

161

P32298
NDNFVKLISWYDNEY

GAPDHS

376

O14556
FIQATDYVEIWQAYL

SART3

411

Q15020
TEYKQFWDVDLGVTY

SCAF8

556

Q9UPN6
TYTFSSGINAIQEWY

SCNN1G

216

P51170
FLYDETQYGTETLWS

SACS

131

Q9NZJ4
YQIWKFGVIFTDNSF

RYR1

4776

P21817
YDNPVTSVFQYEGLW

CLDN18

36

P56856
YVRSGWDNYEFDINE

ECSIT

336

Q9BQ95
SLWALLQQEEYVYFS

DIPK1C

186

Q0P6D2
QLLSSYQFYWGVEEQ

RTL1

836

A6NKG5
SDYFDQLYAWAVELI

QARS1

336

P47897
IEYISYFWVIGNQSS

TAS2R10

81

Q9NYW0
WYATVFNSALYGLEV

TAS2R19

66

P59542
WYATQLNPAFYSVEV

TAS2R30

66

P59541
QDLQGEVEYYTLFWS

USH2A

2951

O75445
DAFYYENNLWILIEF

SLK

96

Q9H2G2
NYYIAAEEISWDYSE

F5

1581

P12259
FQTYFTQDYAQTAWI

SLC16A12

76

Q6ZSM3
ISWYDNEFGYSNRVV

GAPDH

311

P04406
NSTLANYLYWYVIVE

PIK3C3

486

Q8NEB9
FSYPVISYWVDSQDQ

SEMA4A

631

Q9H3S1
TRNEWYDFYLISQVA

PIWIL4

761

Q7Z3Z4
YEYFQVGWNIFDSLI

SCN9A

801

Q15858
YSWQDLVASGVVEYI

POLR2B

651

P30876
WNETTTSVYQYLGFQ

SMIM18

6

P0DKX4
RLWTDQYEEAFTNQY

SETD5

211

Q9C0A6
WYDGEFLYSFTIDNS

ST8SIA1

106

Q92185
PWSNFSFVVEYNYVE

SHOC1

806

Q5VXU9
TDFYTTVNNYWILNA

PGAP1

216

Q75T13
GTDTGVVQYFYIEDW

WDR19

491

Q8NEZ3
VVQYFYIEDWQFVND

WDR19

496

Q8NEZ3
TQGYLVWFEPYQEES

PGBD1

576

Q96JS3
YYFQEGWNIFDGFIV

SCN1A

826

P35498
QVAERALYFWNNEYI

PPP2R5A

366

Q15172
QYNWLSYEDVFVRAF

ACSL3

131

O95573
GDWTYEEQFKQLYEL

ARID3A

221

Q99856
YDFVPDWAEILYQQV

SPG11

2341

Q96JI7
YAGWFYLNFVTEEVE

SLC7A11

246

Q9UPY5
TPQFENISIYNYFVW

TYRP1

176

P17643
EQSVFYWEQVTDGFF

TRIM13

366

O60858
IFSAIWENQFYYLFG

TM9SF4

521

Q92544
GTEQYFNVEVWLQKY

MMP16

36

P51512
QVFLDGNEVYVWIYD

SEC62

176

Q99442
GYFSQYVAWVREEVT

PROM2

736

Q8N271
GYQRFWIETEEYSFE

RYR3

3511

Q15413
RQYYFTNGWNVFDFI

SCN10A

1531

Q9Y5Y9
LFSYSGWDTLNYVTE

SLC7A7

236

Q9UM01
VGLEDTESYDQWLFY

SFMBT2

221

Q5VUG0
YISDVYDFQKQAWFT

USP29

841

Q9HBJ7
VLGIIYDNQVYWYEG

SLC24A5

186

Q71RS6
WVVQLFYAFQDDRYL

ROCK2

151

O75116
DWEEYINNKTNFYTV

SCN8A

301

Q9UQD0
YYFQEGWNIFDGFIV

SCN8A

811

Q9UQD0
YYFDVAEVEAWLGEQ

SPTBN4

1626

Q9H254
SYAAQGWLAFIVEYI

USP20

506

Q9Y2K6
VINGQWYEFDDQYVT

USP20

651

Q9Y2K6
GQISEETWTYLNSLY

USP20

866

Q9Y2K6
SNYTDWFEVYNATRV

TSPAN4

151

O14817
DEVRQWYVNGVNYFT

TRPM8

781

Q7Z2W7
TWYNIFLVYNEERTF

TMEM169

186

Q96HH4
IYFFDQIDELPTYWS

TUT7

1211

Q5VYS8
YESVKYIQQENFWVG

RHBDF2

446

Q6PJF5
TWIFPAEYTQFQNYV

TTLL7

131

Q6ZT98
WSALDGVVYYNSIVI

TGFBR3

511

Q03167
TIQAIGITYFYKEEW

ZRANB3

66

Q5FWF4
ILGSDYSFTQVYNWD

LGI1

491

O95970
YDVDTENFVRYWQQA

LRIG2

541

O94898
YWQQAGEALEYTSIL

LRIG2

551

O94898
YEAEGIAWEPVQYFN

MYO1C

461

O00159