Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	REN ERVK-7 ERVK-21 ERVK-9	1.65e-05	37	83	4	GO:0004190
GeneOntologyMolecularFunction	Rab GDP-dissociation inhibitor activity	GDI1 GDI2	1.71e-05	2	83	2	GO:0005093
GeneOntologyMolecularFunction	aspartic-type peptidase activity	REN ERVK-7 ERVK-21 ERVK-9	1.84e-05	38	83	4	GO:0070001
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN1 CAPN5 CAPN11	4.52e-05	17	83	3	GO:0004198
GeneOntologyMolecularFunction	lactoperoxidase activity	PXDNL LPO	1.02e-04	4	83	2	GO:0140825
GeneOntologyMolecularFunction	endopeptidase activity	RHBDF1 CAPN1 REN ERVK-7 CAPN5 ERVK-21 ERVK-9 CAPN11	4.17e-04	430	83	8	GO:0004175
Domain	Calpain_III	CAPN1 CAPN5 CAPN11	1.56e-05	12	79	3	IPR022683
Domain	calpain_III	CAPN1 CAPN5 CAPN11	1.56e-05	12	79	3	SM00720
Domain	C2_III	CAPN1 CAPN5 CAPN11	1.56e-05	12	79	3	IPR033883
Domain	RabGDI	GDI1 GDI2	1.77e-05	2	79	2	IPR000806
Domain	Calpain_domain_III	CAPN1 CAPN5 CAPN11	2.02e-05	13	79	3	IPR022682
Domain	Calpain_III	CAPN1 CAPN5 CAPN11	2.02e-05	13	79	3	PF01067
Domain	Calpain_cysteine_protease	CAPN1 CAPN5 CAPN11	2.56e-05	14	79	3	IPR022684
Domain	CysPc	CAPN1 CAPN5 CAPN11	3.19e-05	15	79	3	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN1 CAPN5 CAPN11	3.19e-05	15	79	3	IPR001300
Domain	Peptidase_C2	CAPN1 CAPN5 CAPN11	3.19e-05	15	79	3	PF00648
Domain	CALPAIN_CAT	CAPN1 CAPN5 CAPN11	3.19e-05	15	79	3	PS50203
Domain	GDI	GDI1 GDI2	1.05e-04	4	79	2	PF00996
Domain	GDP_dissociation_inhibitor	GDI1 GDI2	1.05e-04	4	79	2	IPR018203
Domain	THIOL_PROTEASE_CYS	CAPN1 CAPN5 CAPN11	1.77e-04	26	79	3	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN1 CAPN5 CAPN11	1.98e-04	27	79	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN1 CAPN5 CAPN11	1.98e-04	27	79	3	PS00639
Domain	ETS_DOMAIN_1	FLI1 ERG ETV2	2.21e-04	28	79	3	PS00345
Domain	ETS_DOMAIN_2	FLI1 ERG ETV2	2.21e-04	28	79	3	PS00346
Domain	ETS	FLI1 ERG ETV2	2.21e-04	28	79	3	SM00413
Domain	Ets_dom	FLI1 ERG ETV2	2.21e-04	28	79	3	IPR000418
Domain	ETS_DOMAIN_3	FLI1 ERG ETV2	2.21e-04	28	79	3	PS50061
Domain	Ets	FLI1 ERG ETV2	2.21e-04	28	79	3	PF00178
Domain	Pept_cys_AS	CAPN1 CAPN5 CAPN11	2.21e-04	28	79	3	IPR000169
Domain	-	TDRD15 RNF17	2.62e-04	6	79	2	2.40.50.90
Domain	PEROXIDASE_1	PXDNL LPO	2.62e-04	6	79	2	PS00435
Domain	Staphylococal_nuclease_OB-fold	TDRD15 RNF17	2.62e-04	6	79	2	IPR016071
Domain	Haem_peroxidase	PXDNL LPO	7.78e-04	10	79	2	IPR010255
Domain	An_peroxidase	PXDNL LPO	7.78e-04	10	79	2	PF03098
Domain	PEROXIDASE_3	PXDNL LPO	7.78e-04	10	79	2	PS50292
Domain	Haem_peroxidase_animal	PXDNL LPO	7.78e-04	10	79	2	IPR019791
Domain	-	PXDNL LPO	7.78e-04	10	79	2	1.10.640.10
Domain	PNT	FLI1 ERG	9.48e-04	11	79	2	PS51433
Domain	Pointed_dom	FLI1 ERG	9.48e-04	11	79	2	IPR003118
Domain	SAM_PNT	FLI1 ERG	9.48e-04	11	79	2	PF02198
Domain	SAM_PNT	FLI1 ERG	9.48e-04	11	79	2	SM00251
Domain	TUDOR	TDRD15 RNF17	1.56e-03	14	79	2	PF00567
Domain	-	GPD2 GDI1 GDI2	1.72e-03	56	79	3	3.50.50.60
Domain	FAD/NAD-binding_dom	GPD2 GDI1 GDI2	1.81e-03	57	79	3	IPR023753
Domain	Peptidase_aspartic_dom	RTL1 REN	2.31e-03	17	79	2	IPR021109
Domain	TUDOR	TDRD15 RNF17	4.22e-03	23	79	2	PS50304
Domain	TUDOR	TDRD15 RNF17	5.79e-03	27	79	2	SM00333
Domain	FBG	FIBCD1 CNTNAP4	6.66e-03	29	79	2	SM00186
Domain	Tudor	TDRD15 RNF17	7.12e-03	30	79	2	IPR002999
Domain	-	FIBCD1 CNTNAP4	7.12e-03	30	79	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	FIBCD1 CNTNAP4	7.12e-03	30	79	2	IPR014716
Domain	FIBRINOGEN_C_1	FIBCD1 CNTNAP4	8.07e-03	32	79	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	FIBCD1 CNTNAP4	8.07e-03	32	79	2	IPR002181
Domain	FIBRINOGEN_C_2	FIBCD1 CNTNAP4	8.07e-03	32	79	2	PS51406
Pubmed	Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.	FLI1 ERG ETV2	4.10e-06	13	86	3	25802403
Pubmed	WNK4 inhibits plasma membrane targeting of NCC through regulation of syntaxin13 SNARE formation.	SLC12A3 WNK4	6.04e-06	2	86	2	23993962
Pubmed	ERG and FLI1 protein expression in epithelioid sarcoma.	FLI1 ERG	6.04e-06	2	86	2	24072183
Pubmed	Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis.	FLI1 ERG	6.04e-06	2	86	2	28248553
Pubmed	The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.	FLI1 ERG	6.04e-06	2	86	2	10704859
Pubmed	Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.	FLI1 ERG	6.04e-06	2	86	2	30500808
Pubmed	Transdifferentiation of erythroblasts to megakaryocytes using FLI1 and ERG transcription factors.	FLI1 ERG	6.04e-06	2	86	2	26063314
Pubmed	Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population.	SLC12A3 WNK4	6.04e-06	2	86	2	15309683
Pubmed	Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.	DOK7 CRKL	6.04e-06	2	86	2	34163073
Pubmed	Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.	FLI1 ERG	6.04e-06	2	86	2	33275876
Pubmed	Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.	GDI1 GDI2	6.04e-06	2	86	2	7585614
Pubmed	ERG and FLI1 are useful immunohistochemical markers in phosphaturic mesenchymal tumors.	FLI1 ERG	6.04e-06	2	86	2	26122367
Pubmed	Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.	SLC12A3 WNK4	6.04e-06	2	86	2	19633012
Pubmed	The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain.	CAPN1 NFKBIA	6.04e-06	2	86	2	10521480
Pubmed	Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement.	SLC12A3 WNK4	6.04e-06	2	86	2	24026181
Pubmed	Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II.	SLC12A3 WNK4	6.04e-06	2	86	2	21196779
Pubmed	Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.	SLC12A3 WNK4	6.04e-06	2	86	2	12515852
Pubmed	WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.	SLC12A3 WNK4	6.04e-06	2	86	2	16688122
Pubmed	Histone deacetylase 6 regulates insulin signaling in pancreatic β cells.	HDAC6 LEPR	6.04e-06	2	86	2	33168187
Pubmed	Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.	FLI1 ERG	6.04e-06	2	86	2	19666492
Pubmed	WNK4 is the major WNK positively regulating NCC in the mouse kidney.	SLC12A3 WNK4	6.04e-06	2	86	2	24655003
Pubmed	Differential roles of WNK4 in regulation of NCC in vivo.	SLC12A3 WNK4	6.04e-06	2	86	2	29384416
Pubmed	Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs.	ERN1 LEPR	6.04e-06	2	86	2	27634225
Pubmed	Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.	SLC12A3 WNK4	6.04e-06	2	86	2	16964266
Pubmed	Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.	SLC12A3 WNK4	6.04e-06	2	86	2	22846565
Pubmed	Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation.	FLI1 ERG ETV2	7.99e-06	16	86	3	24727028
Pubmed	PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.	ERN1 LEPR	1.81e-05	3	86	2	21911379
Pubmed	WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway.	SLC12A3 WNK4	1.81e-05	3	86	2	19875813
Pubmed	RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.	GDI1 GDI2	1.81e-05	3	86	2	26240314
Pubmed	The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.	SLC12A3 WNK4	1.81e-05	3	86	2	17975670
Pubmed	Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group.	FLI1 ERG	1.81e-05	3	86	2	20308669
Pubmed	Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.	FLI1 ERG	1.81e-05	3	86	2	20308673
Pubmed	I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway.	CAPN1 NFKBIA	1.81e-05	3	86	2	20659425
Pubmed	Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.	SLC12A3 WNK4	1.81e-05	3	86	2	16788137
Pubmed	FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells.	FLI1 ERG	1.81e-05	3	86	2	32979864
Pubmed	A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.	FLI1 ERG	1.81e-05	3	86	2	20676125
Pubmed	Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.	ERN1 LEPR	1.81e-05	3	86	2	30885990
Pubmed	Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.	GDI1 GDI2	1.81e-05	3	86	2	7543319
Pubmed	Association of FTO, LEPR and MTHFR gene polymorphisms with metabolic syndrome in schizophrenia patients receiving antipsychotics.	MTHFR LEPR	1.81e-05	3	86	2	24624915
Pubmed	Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.	SLC12A3 WNK4	1.81e-05	3	86	2	19240212
Pubmed	Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.	SLC12A3 WNK4	1.81e-05	3	86	2	26728390
Pubmed	HDAC6 mediates the acetylation of TRIM50.	HDAC6 TNK2	1.81e-05	3	86	2	24308962
Pubmed	Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer.	FLI1 ERG	1.81e-05	3	86	2	16484587
Pubmed	A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.	ERN1 LEPR	1.81e-05	3	86	2	20103773
Pubmed	Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.	GDI1 GDI2	1.81e-05	3	86	2	7513052
Pubmed	WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction.	SLC12A3 WNK4	1.81e-05	3	86	2	19401467
Pubmed	Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.	SLC12A3 WNK4	1.81e-05	3	86	2	19690383
Pubmed	A SMARCB1-deficient vulvar neoplasm with prominent myxoid stroma: report of a case showing ERG and FLI1 expression.	FLI1 ERG	1.81e-05	3	86	2	26261664
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	IFT140 CNTNAP4 DSCAML1 PLXNA2 MADD	1.85e-05	130	86	5	12421765
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	FLI1 ERG ETV2	2.85e-05	24	86	3	22056786
Pubmed	Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression.	ERN1 LEPR	3.61e-05	4	86	2	27938665
Pubmed	Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.	CAPN1 LEPR	3.61e-05	4	86	2	26470784
Pubmed	Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.	SLC12A3 WNK4	3.61e-05	4	86	2	23665031
Pubmed	The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.	FLI1 ERG	3.61e-05	4	86	2	18500345
Pubmed	Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.	ERN1 LEPR	3.61e-05	4	86	2	19996103
Pubmed	Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia.	SLC12A3 WNK4	3.61e-05	4	86	2	24206662
Pubmed	Sulforaphane reduces obesity by reversing leptin resistance.	HDAC6 LEPR	3.61e-05	4	86	2	35323110
Pubmed	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.	FLI1 ERG	3.61e-05	4	86	2	20517297
Pubmed	Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.	ERN1 MTHFR	3.61e-05	4	86	2	18065414
Pubmed	ETS-family genes in pancreatic development.	FLI1 ERG ETV2	5.09e-05	29	86	3	17907201
Pubmed	TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.	FLI1 ERG	6.01e-05	5	86	2	34329586
Pubmed	HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity.	HDAC6 TNK2	6.01e-05	5	86	2	23402884
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-7 ERVK-21	6.01e-05	5	86	2	12629516
Pubmed	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.	GDI1 GDI2	6.01e-05	5	86	2	19570034
Pubmed	Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.	SLC12A3 WNK4	6.01e-05	5	86	2	18800028
Pubmed	An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation.	FLI1 ERG	6.01e-05	5	86	2	38695236
Pubmed	Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.	CAPN1 CAPN5	6.01e-05	5	86	2	14981075
Pubmed	Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.	IFT140 CRKL	6.01e-05	5	86	2	23469164
Pubmed	Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.	GDI1 GDI2	6.01e-05	5	86	2	11929610
Pubmed	ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.	ERN1 LEPR	6.01e-05	5	86	2	23314846
Pubmed	IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.	FLI1 ERG	6.01e-05	5	86	2	18648544
Pubmed	Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.	SLC12A3 WNK4	6.01e-05	5	86	2	19008908
Pubmed	Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.	HDAC6 LEPR	6.01e-05	5	86	2	38569472
Pubmed	Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.	CAPN5 CAPN11	9.01e-05	6	86	2	10559499
Pubmed	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.	GDI1 GDI2	9.01e-05	6	86	2	11809807
Pubmed	A novel zinc finger gene is fused to EWS in small round cell tumor.	FLI1 ERG	9.01e-05	6	86	2	10949935
Pubmed	Lrp4 is a receptor for Agrin and forms a complex with MuSK.	DOK7 CRKL	1.26e-04	7	86	2	18848351
Pubmed	Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.	FLI1 ERG	1.26e-04	7	86	2	23327922
Pubmed	Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction.	GDI1 MADD	1.26e-04	7	86	2	11359932
Pubmed	Structure and physiological function of calpains.	CAPN1 CAPN5	1.26e-04	7	86	2	9396712
Pubmed	Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm.	FLI1 ETV2	1.68e-04	8	86	2	21911838
Pubmed	LRP4 serves as a coreceptor of agrin.	DOK7 CRKL	1.68e-04	8	86	2	18957220
Pubmed	Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.	FLI1 ERG	1.68e-04	8	86	2	9681824
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN1 CAPN5	1.68e-04	8	86	2	9473662
Pubmed	Agrin acts via a MuSK receptor complex.	DOK7 CRKL	1.68e-04	8	86	2	8653787
Pubmed	Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients.	CWF19L2 CNTNAP4	1.68e-04	8	86	2	18398821
Pubmed	Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.	SLC12A3 LEPR	1.68e-04	8	86	2	18496130
Pubmed	Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.	DOK7 CRKL	2.15e-04	9	86	2	21041412
Pubmed	Implication of geranylgeranyltransferase I in synapse formation.	DOK7 CRKL	2.68e-04	10	86	2	14622576
Pubmed	Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.	SLC12A3 WNK4	3.93e-04	12	86	2	23684652
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-21 ERVK-9	3.93e-04	12	86	2	14557543
Pubmed	MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.	FLI1 ERG	4.63e-04	13	86	2	27570068
Pubmed	HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.	TNK2 CRKL	5.39e-04	14	86	2	28739485
Pubmed	Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.	RHBDF1 MTHFR	6.21e-04	15	86	2	20970119
Pubmed	HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.	HDAC6 NFKBIA	6.21e-04	15	86	2	26031809
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	SLC12A3 WNK4	7.09e-04	16	86	2	15824464
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	GRTP1 EVA1A ST8SIA2 LEPR	7.49e-04	164	86	4	22967998
Pubmed	Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression.	MAEL RNF17	8.02e-04	17	86	2	19345099
Pubmed	The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development.	FLI1 ETV2	8.02e-04	17	86	2	27239041
Pubmed	Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.	RTL1 LEPR	9.01e-04	18	86	2	23085235
Cytoband	6p12.1	KIAA1586 GSTA3	1.80e-03	33	87	2	6p12.1
GeneFamily	C2 domain containing\|Calpains	CAPN1 CAPN5 CAPN11	8.32e-06	15	49	3	975
GeneFamily	ETS transcription factor family	FLI1 ERG ETV2	5.84e-05	28	49	3	534
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	IFT140 GPATCH3 MTHFR RNF39 KIF1C	1.40e-05	162	84	5	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATAD3B FAM83F FIBCD1 DSCAML1 WNK4	2.14e-05	177	84	5	e1e45956887371b1c18f1eb479dd930031497520
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAAA SLC20A2 SIPA1L3 PFAS CLSPN	2.26e-05	179	84	5	9dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCell	severe-multiplets\|World / disease stage, cell group and cell class	ATAD3B SLC12A3 FAM83F SGO2 CLSPN	2.44e-05	182	84	5	5e30ec7120a988d9ee3000513e1209618f28f5f9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 STAB2 CNTNAP4 DSCAML1 DNAH1	2.57e-05	184	84	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 STAB2 CNTNAP4 DSCAML1 DNAH1	2.57e-05	184	84	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 STAB2 CNTNAP4 DSCAML1 DNAH1	2.57e-05	184	84	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 EVA1A LPO ANTXR1 WNK4	2.57e-05	184	84	5	8939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLI1 ERG LEPR PLXNA2 SNTB2	2.78e-05	187	84	5	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	IFT140 NEBL SYTL4 SIPA1L3 RNF39	2.85e-05	188	84	5	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	IFT140 NEBL SYTL4 SIPA1L3 RNF39	2.85e-05	188	84	5	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	FLI1 ERG LEPR PLXNA2 SNTB2	2.93e-05	189	84	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLI1 ERG CNTNAP4 LEPR PLXNA2	3.16e-05	192	84	5	56b021c297a21dff357531f21e2464f85186106d
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	FLI1 ERG LEPR PLXNA2 SNTB2	3.32e-05	194	84	5	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Intermediate\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	FIBCD1 ETV2 TNK2 DSCAML1 GSTA3	3.83e-05	200	84	5	401d50fa394fa863fa7836344110ae5c7af3250a
ToppCell	MS-IIF\|MS / Disease, condition lineage and cell class	CWF19L2 SYTL4 NFKBIA OSBP2 SLC25A37	3.83e-05	200	84	5	221f59edcfc18baece13184c2552d26022228146
Drug	Diphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; PC3; HT_HG-U133A	NCOA2 GPD2 STAB2 GPATCH3 SLC20A2 OSBP2 RNF17	8.03e-06	198	83	7	3743_UP
Drug	Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A	MTHFR ANTXR1 RNF17 LEPR PLXNA2 CRKL KIF1C	8.03e-06	198	83	7	5416_UP
Drug	Repaglinide [135062-02-1]; Up 200; 8.8uM; PC3; HT_HG-U133A	GPD2 IFT140 STAB2 HDAC6 NEBL MTHFR ZFP30	8.03e-06	198	83	7	5862_UP
Drug	PFNA	NCOA2 NFKBIA PFAS	1.30e-05	13	83	3	CID000067821
Disease	Gitelman syndrome (implicated_via_orthology)	SLC12A3 WNK4	2.23e-05	3	81	2	DOID:0050450 (implicated_via_orthology)
Disease	Extra-osseous Ewing's sarcoma	FLI1 ERG	4.45e-05	4	81	2	C0279980
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN1 CAPN11	7.40e-05	5	81	2	DOID:0110821 (implicated_via_orthology)
Disease	Kidney Diseases	SLC12A3 MTHFR REN LEPR	1.03e-04	88	81	4	C0022658
Disease	Anemia	MTHFR REN SLC25A37	1.12e-04	34	81	3	C0002871
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN1 SNTB2 CAPN11	1.33e-04	36	81	3	DOID:11723 (implicated_via_orthology)
Disease	Ewings sarcoma	FLI1 ERG	2.06e-04	8	81	2	C0553580
Disease	free androgen index	SYTL4 SLC20A2 DOK7 REN SLC25A37 LEPR	5.81e-04	374	81	6	EFO_0007005
Disease	polycystic kidney disease (implicated_via_orthology)	XYLT2 HDAC6	6.63e-04	14	81	2	DOID:0080322 (implicated_via_orthology)
Disease	cholangiocarcinoma (is_marker_for)	HDAC6 OSBP2 RNF39	7.36e-04	64	81	3	DOID:4947 (is_marker_for)
Disease	Schizoaffective disorder-bipolar type	MYO1G STAB2	8.71e-04	16	81	2	EFO_0009965
Disease	dual specificity mitogen-activated protein kinase kinase 2 measurement	GRTP1 ADPRHL1	8.71e-04	16	81	2	EFO_0008112
Disease	mean corpuscular hemoglobin concentration	IFT140 ERG HPD MTHFR SLC20A2 ANTXR1 PFAS CLSPN SLC25A37 LEPR	8.78e-04	1105	81	10	EFO_0004528
Disease	Vascular Diseases	SLC12A3 MTHFR	9.85e-04	17	81	2	C0042373
Disease	essential hypertension (is_implicated_in)	SLC12A3 REN	1.11e-03	18	81	2	DOID:10825 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	MTHFR LEPR	1.11e-03	18	81	2	DOID:0080208 (is_implicated_in)
Disease	chronic myeloid leukemia (is_implicated_in)	MTHFR CRKL	1.51e-03	21	81	2	DOID:8552 (is_implicated_in)
Disease	Nephritis, Tubulointerstitial	SLC12A3 REN	1.51e-03	21	81	2	C0041349
Disease	hepatocellular carcinoma (is_implicated_in)	ERN1 MTHFR NFKBIA LEPR	1.58e-03	181	81	4	DOID:684 (is_implicated_in)
Disease	colorectal carcinoma (is_implicated_in)	NCOA2 ANTXR1	1.66e-03	22	81	2	DOID:0080199 (is_implicated_in)
Disease	response to anticonvulsant	TDRD15 NEBL LEPR	1.67e-03	85	81	3	GO_0036277
Disease	Hypertensive disease	SLC12A3 REN LEPR WNK4	1.88e-03	190	81	4	C0020538
Disease	Nephritis, Interstitial	SLC12A3 REN	1.98e-03	24	81	2	C0027707
Disease	Albuminuria	REN LEPR	1.98e-03	24	81	2	C0001925
Disease	thrombocytopenia (is_implicated_in)	FLI1 MTHFR	2.50e-03	27	81	2	DOID:1588 (is_implicated_in)
Disease	Subfertility, Female	MTHFR LEPR	2.69e-03	28	81	2	C0341869
Disease	Sterility, Postpartum	MTHFR LEPR	2.69e-03	28	81	2	C0038279
Disease	Female sterility	MTHFR LEPR	2.69e-03	28	81	2	C0917730
Disease	Female infertility	MTHFR LEPR	2.69e-03	28	81	2	C0021361

Protein segments in the cluster

Peptide	Gene	Start	Entry
FGQRWARGPDMLEQK	AMER3	706	Q8N944
VVRRMPRKRISGLEW	LINC01551	21	Q86U37
VRAREGVWIPVSMDR	ERVK-9	426	Q9UKH3
RGVGGIKRMEVRWGE	ANTXR1	386	Q9H6X2
VMVEEWRRPAGHRRK	CALHM3	76	Q86XJ0
EVARRWGERKSKPNM	ERG	346	P11308
EWNPKGRIGMRIEVF	CNTNAP4	161	Q9C0A0
KLDMIRLRNPWGERE	CAPN5	276	O15484
KMETLIRVRNPWGRI	CAPN11	311	Q9UMQ6
GQVVSLIRMRNPWGE	CAPN1	286	P07384
LEKIGMGRPGQRRLW	TNK2	46	Q07912
MGRPGQRRLWEAVKR	TNK2	51	Q07912
ERERIIREIWMNGQP	EVA1A	126	Q9H8M9
DVIKGRPVRIMWSQR	PABPC1L2A	66	Q5JQF8
EVLKRLGMWTEDPRR	MTHFR	331	P42898
MGRGRDWNVDLIPKF	GDI2	66	P50395
MASVTGKRWPIVGVR	GPD2	511	P43304
KLGIPRGVQRDTMWR	MADD	211	Q8WXG6
EMAREWRAAQGKDPG	MAEL	56	Q96JY0
RAAMAQVIGDRVPKW	NAAA	61	Q02083
DGIQPMWEDSRNKRG	EIF4E1B	121	A6NMX2
QGRPIPEWKRQVMVR	ESPN	746	B1AK53
NRDWIPMVVELRSRG	FREM2	276	Q5SZK8
NGRGRMEPIRWLLAA	GSTA3	11	Q16772
KGIGRKVMERQGWAE	GPATCH3	411	Q96I76
PRAVDMDLEWRQGRI	PLXNA2	1546	O75051
TEIIKIGRVMGPRWA	KIAA1586	471	Q9HCI6
WRMVKDGGIDPLVRG	LPO	501	P22079
GGMLDIEPRLWRKGI	CWF19L2	851	Q2TBE0
RRRLQGKDPRWATMA	KIF1C	731	O43896
RGPEFWRIINGDTMK	LEPR	641	P48357
WAMEGPRDGLKKERL	NFKBIA	11	P25963
WSARNKDGRVGMIPV	CRKL	161	P46109
RLRPDQRLMEKGRWD	OSBP2	821	Q969R2
TDVRGVPRKAEERWM	PXDNL	1396	A1KZ92
RWYPVPQREMDRRKG	GALNT1	266	Q10472
ELREWMKGIPERLVG	DNAH1	866	Q9P2D7
VRAREGVWIPVSMDR	ERVK-7	316	P61567
QLERGGRAVVKMDWR	ERN1	861	O75460
SGDMPIRITWRKDGQ	DSCAML1	621	Q8TD84
RKGVPLEHRARVWMV	GRTP1	66	Q5TC63
RVRGDGRPWMVNIKE	NDUFAF1	211	Q9Y375
EVARRWGERKSKPNM	FLI1	316	Q01543
GKPLVQWGRDMLRAV	ADPRHL1	186	Q8NDY3
VRAREGVWIPVSMDR	ERVK-21	426	P61565
WKTMGGAAQLEDRPR	FIBCD1	6	Q8N539
MGRGRDWNVDLIPKF	GDI1	66	P31150
WNPRIKEVYMRGITR	CCDC168	3866	Q8NDH2
WLGTRRRGLVMEAPQ	DOK7	446	Q18PE1
WRSLRVMKVEDREGP	HDAC6	831	Q9UBN7
EVARLWGERKRKPGM	ETV2	276	O00321
WGRRVIQTMGKDLTP	SLC20A2	551	Q08357
AGTDRGRVAMWRKVP	IFT140	341	Q96RY7
RERGAKIMREPWVEQ	HPD	111	P32754
WEPVGARMQERARLQ	RTL1	616	A6NKG5
QMGDIWPGRKIIQER	SYTL4	161	Q96C24
EMKIRRRRHEGPAWG	TMEM105	76	Q8N8V8
RVSGEWQRGRVMEKK	TDRD15	71	B5MCY1
LKERGVDMARLGPEW	REN	46	P00797
LQMWQVPEGEKRRRL	PNMA3	191	Q9UL41
RTEGFWRPLRGVNVM	SLC25A37	96	Q9NYZ2
LMLPLERGWRKQKEG	RHBDF1	316	Q96CC6
KMGVRARVADWPPKR	SIPA1L3	76	O60292
PAFMARGGKERVEWV	ST8SIA2	241	Q92186
EMRNAQSIGRRWEKP	SGO2	251	Q562F6
ESGAKRPWRKQRVDM	SI	766	P14410
MIRWGEEKRQADPGF	PMVK	76	Q15126
PPGEMMRWAARQQRE	FAM83F	336	Q8NEG4
PGAWENRTRKDMERG	APOBR	621	Q0VD83
RQKMRWLKAEGPGRG	ATAD3B	566	Q5T9A4
GPGRMRKFRWKNIDD	CLSPN	1131	Q9HAW4
VVREERDMVGWPRKN	CNKSR1	251	Q969H4
AMKPGWEDLVRRCIQ	NCOA2	291	Q15596
QRMGRKSQPWGAAEI	RNF17	16	Q9BXT8
EDNRRWMRENVPGEK	SH3BGR	106	P55822
QGKEPWMVVRDEKRR	ZFP30	61	Q9Y2G7
VRLVETPGRELWRMV	SOX12	176	O15370
QRREWIKPIMFSGGI	PFAS	416	O15067
QGKEPWMIVREETRG	ZNF607	61	Q96SK3
EEPVRFGWVKGVMIR	SLC12A3	131	P55017
MERLRELNTEPRGKW	STAB2	366	Q8WWQ8
AKLDGGRQQWRPVLM	SNTB2	336	Q13425
GGVWRVVYMPRKQDI	PNMA8C	91	A0A1B0GUJ8
PGLKLWLRMEDARRG	WNK4	451	Q96J92
MWRLGERQIPAGIVV	XYLT2	381	Q9H1B5
LPGEDMRKTWRRFEV	RNF39	186	Q9H2S5
WVVNRINSVMEPRGR	MYO1G	366	B0I1T2
MDRRPGIIVDLKVWR	NEBL	831	O76041