Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9A8 SLC9A4 SLC9A5	1.40e-04	14	149	3	GO:0015386
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A8 SLC9A4 SLC9A5	2.12e-04	16	149	3	GO:0015385
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	SUCLG1 ACSL1 UBA1 ACSM3	2.43e-04	41	149	4	GO:0016877
Domain	FAM86	FAM86B1 FAM86B2 EEF2KMT	1.94e-06	4	148	3	IPR029426
Domain	FAM86	FAM86B1 FAM86B2 EEF2KMT	1.94e-06	4	148	3	PF14904
Domain	NaH_exchanger	SLC9A8 SLC9A4 SLC9A5	3.96e-05	9	148	3	IPR004709
Domain	Cadherin	PCDHGA10 PCDHB14 FREM1 FREM2 CELSR3 PCDHGA12 PCDH7	4.31e-05	118	148	7	IPR002126
Domain	Methyltransf_16	FAM86B1 FAM86B2 EEF2KMT	7.68e-05	11	148	3	IPR019410
Domain	Cation/H_exchanger_CPA1	SLC9A8 SLC9A4 SLC9A5	7.68e-05	11	148	3	IPR018422
Domain	Methyltransf_16	FAM86B1 FAM86B2 EEF2KMT	7.68e-05	11	148	3	PF10294
Domain	DH_1	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	1.42e-04	63	148	5	PS00741
Domain	Na_H_Exchanger	SLC9A8 SLC9A4 SLC9A5	1.66e-04	14	148	3	PF00999
Domain	Cation/H_exchanger	SLC9A8 SLC9A4 SLC9A5	1.66e-04	14	148	3	IPR006153
Domain	RhoGEF	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	2.04e-04	68	148	5	SM00325
Domain	LAM_G_DOMAIN	CNTNAP3B CNTNAP3 CELSR3 CSPG4	2.27e-04	38	148	4	PS50025
Domain	RhoGEF	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	2.34e-04	70	148	5	PF00621
Domain	DH_2	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	2.34e-04	70	148	5	PS50010
Domain	-	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	2.50e-04	71	148	5	1.20.900.10
Domain	DH-domain	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	2.50e-04	71	148	5	IPR000219
Domain	Laminin_G_2	CNTNAP3B CNTNAP3 CELSR3 CSPG4	2.77e-04	40	148	4	PF02210
Domain	CA	PCDHGA10 PCDHB14 FREM2 CELSR3 PCDHGA12 PCDH7	3.10e-04	115	148	6	SM00112
Domain	LamG	CNTNAP3B CNTNAP3 CELSR3 CSPG4	4.02e-04	44	148	4	SM00282
Domain	PDEase	PDE4A PDE4C PDE4D	4.30e-04	19	148	3	IPR023088
Domain	PDEase_I	PDE4A PDE4C PDE4D	5.84e-04	21	148	3	PF00233
Domain	PDEASE_I	PDE4A PDE4C PDE4D	5.84e-04	21	148	3	PS00126
Domain	PDEase_CS	PDE4A PDE4C PDE4D	5.84e-04	21	148	3	IPR023174
Domain	Bcl2_BH4	BOK BCL2L13	6.14e-04	5	148	2	IPR003093
Domain	BH4_2	BOK BCL2L13	6.14e-04	5	148	2	PS50063
Domain	BH4_1	BOK BCL2L13	6.14e-04	5	148	2	PS01260
Domain	-	PDE4A PDE4C PDE4D	6.72e-04	22	148	3	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4A PDE4C PDE4D	7.69e-04	23	148	3	IPR002073
Domain	HD/PDEase_dom	PDE4A PDE4C PDE4D	8.73e-04	24	148	3	IPR003607
Domain	HDc	PDE4A PDE4C PDE4D	8.73e-04	24	148	3	SM00471
Domain	-	EPPK1 DSP	9.16e-04	6	148	2	3.90.1290.10
Domain	FAT	ATR TRRAP	9.16e-04	6	148	2	PS51189
Domain	FATC	ATR TRRAP	9.16e-04	6	148	2	PS51190
Domain	FAT	ATR TRRAP	9.16e-04	6	148	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR TRRAP	9.16e-04	6	148	2	IPR003151
Domain	FATC_dom	ATR TRRAP	9.16e-04	6	148	2	IPR003152
Domain	PIK_FAT	ATR TRRAP	9.16e-04	6	148	2	IPR014009
Domain	FATC	ATR TRRAP	9.16e-04	6	148	2	SM01343
Domain	Laminin_G	CNTNAP3B CNTNAP3 CELSR3 CSPG4	1.15e-03	58	148	4	IPR001791
Domain	Plectin	EPPK1 DSP	1.28e-03	7	148	2	PF00681
Domain	Plectin_repeat	EPPK1 DSP	1.28e-03	7	148	2	IPR001101
Domain	PLEC	EPPK1 DSP	1.28e-03	7	148	2	SM00250
Domain	Cadherin_CS	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	1.76e-03	109	148	5	IPR020894
Domain	Cadherin_2	PCDHGA10 PCDHB14 PCDHGA12 PCDH7	1.76e-03	65	148	4	PF08266
Domain	Cadherin_N	PCDHGA10 PCDHB14 PCDHGA12 PCDH7	1.76e-03	65	148	4	IPR013164
Domain	CADHERIN_1	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	2.06e-03	113	148	5	PS00232
Domain	Cadherin	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	2.06e-03	113	148	5	PF00028
Domain	CADHERIN_2	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	2.15e-03	114	148	5	PS50268
Domain	-	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	2.15e-03	114	148	5	2.60.40.60
Domain	Calx_beta	FREM1 FREM2	2.16e-03	9	148	2	IPR003644
Domain	NHL_repeat_subgr	NHLRC2 PAM	2.16e-03	9	148	2	IPR013017
Domain	Calx-beta	FREM1 FREM2	2.16e-03	9	148	2	PF03160
Domain	Cadherin-like	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	2.31e-03	116	148	5	IPR015919
Pathway	REACTOME_PROTEIN_METHYLATION	FAM86B1 FAM86B2 EEF2KMT VCP	2.14e-05	22	108	4	MM15519
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A8 SLC9A4 SLC9A5	3.55e-05	9	108	3	M27337
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A8 SLC9A4 SLC9A5	3.55e-05	9	108	3	MM15079
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4C PDE4D	2.28e-04	16	108	3	MM14699
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	A2M PRSS1 COL6A3 PRSS2 BCAN LPA	2.40e-04	114	108	6	MM14571
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	GPAA1 ATR ANPEP SLC39A1 HACD3 CNTNAP3 ITGA6 ECE1 ABCA7 HSPA13 UBA1 CELSR3 CXCR4 CSPG4 PAM SGCE BACE2 ENG PCDH7 VCP SORL1	5.51e-08	1201	150	21	35696571
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	9371714
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	34943270
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	8413254
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	22946044
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	33609559
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4C PDE4D	3.14e-07	4	150	3	24732776
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	COL6A3 FREM1 FREM2 CSPG4	5.81e-07	16	150	4	16880404
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4C PDE4D	7.81e-07	5	150	3	33944911
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4C PDE4D	7.81e-07	5	150	3	8586960
Pubmed	FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis.	FAM86B1 FAM86B2 EEF2KMT	7.81e-07	5	150	3	38508183
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4A PDE4C PDE4D	1.56e-06	6	150	3	18923023
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	COL6A3 FREM1 FREM2	9.23e-06	10	150	3	15345741
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	RC3H2 HACD3 CABLES1 EIF3L DHPS BOP1 DNMBP VPS53	1.43e-05	251	150	8	29778605
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PRSS1 PRSS2 GPAA1 SLC39A1 HACD3 TAPBPL DSP SUCLG1 NDUFS6 ACSL1 FADS3 CLCN5 CSPG4 PAM MRPL41 ENG DNAH6 VCP PTCD3	1.67e-05	1451	150	19	30550785
Pubmed	Neuron/Glial Antigen 2-Type VI Collagen Interactions During Murine Temporomandibular Joint Osteoarthritis.	COL6A3 CSPG4	1.85e-05	2	150	2	30635602
Pubmed	Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.	CNTNAP3B CNTNAP3	1.85e-05	2	150	2	26807827
Pubmed	Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.	PRSS1 PRSS2	1.85e-05	2	150	2	36191639
Pubmed	Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus?	ARSG CACNA2D3	1.85e-05	2	150	2	24375517
Pubmed	Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses.	PRSS1 PRSS2	1.85e-05	2	150	2	33202925
Pubmed	Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.	PDE4A PDE4D	1.85e-05	2	150	2	9520403
Pubmed	Differential expression of type I hair keratins.	KRT33A KRT33B	1.85e-05	2	150	2	1689759
Pubmed	Pre-diagnostic levels of anionic trypsinogen, cationic trypsinogen, and pancreatic secretory trypsin inhibitor in relation to pancreatic cancer risk.	PRSS1 PRSS2	1.85e-05	2	150	2	20484960
Pubmed	Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids.	DSP ITGA6	1.85e-05	2	150	2	33502623
Pubmed	The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.	CNTNAP3B CNTNAP3	1.85e-05	2	150	2	31150793
Pubmed	A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos.	FREM1 FREM2	1.85e-05	2	150	2	29688405
Pubmed	Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.	PRSS1 PRSS2	1.85e-05	2	150	2	27846138
Pubmed	Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.	PDE4A PDE4C	1.85e-05	2	150	2	23043089
Pubmed	Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).	PRSS1 PRSS2	1.85e-05	2	150	2	14695529
Pubmed	Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.	PRSS1 PRSS2	1.85e-05	2	150	2	15776435
Pubmed	A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms.	KRT33A KRT33B	1.85e-05	2	150	2	7565656
Pubmed	Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation.	PRSS1 PRSS2	1.85e-05	2	150	2	18461367
Pubmed	Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer.	PRSS1 PRSS2	1.85e-05	2	150	2	15651064
Pubmed	Immunoreactive anionic and cationic trypsin in human serum.	PRSS1 PRSS2	1.85e-05	2	150	2	2598466
Pubmed	Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.	PRSS1 PRSS2	1.85e-05	2	150	2	35089416
Pubmed	Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis.	PRSS1 PRSS2	1.85e-05	2	150	2	18063422
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4A PDE4C PDE4D	2.18e-05	13	150	3	8009369
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PDE4A EPPK1 ECE1 RALGAPA2 DCTN1 TRRAP ABCA7 ARSG ARHGEF10L CABLES1 NHSL1 CELSR3 CSPG4 RIPOR1 DNMBP BCL2L13	2.47e-05	1105	150	16	35748872
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGA10 PCDHB14 CELSR3 PCDHGA12 PCDH7	2.59e-05	80	150	5	10716726
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	A2M PRSS1 PRSS2 RC3H2 ATR ECE1 PHKA2 PACS1 FREM2 SLC22A4 PAM SORL1	2.72e-05	650	150	12	38777146
Pubmed	E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.	PRSS1 PDE4A DSP CRACD UBA1 VCP	2.77e-05	135	150	6	29859926
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PDE4C ATR HACD3 DSP TRRAP PACS1 PHC3 UBA1 BRD8 ZBTB40 RIPOR1 DNMBP PCDH7	3.33e-05	774	150	13	15302935
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC9A8 CPS1 SLC4A1 SLC9A4 SLC12A3 CLCN5 SORL1	3.99e-05	212	150	7	19521566
Pubmed	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	FAM86B1 FAM86B2 EEF2KMT UBA1 HSPA7 VCP	4.13e-05	145	150	6	23349634
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	A2M PRSS1 EPPK1 ATR DSP ITGA6 UBA1 EIF3L VCP PTCD3	4.54e-05	477	150	10	31300519
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PRSS1 PDE4D ACAT1 HACD3 DSP BCAN SUCLG1 DCTN1 SLC4A1 NHSL1 PACS1 CRACD UBA1 EIF3L DNAH6 VCP CACNA2D3 PTCD3	4.78e-05	1431	150	18	37142655
Pubmed	Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.	PRSS1 PRSS2	5.53e-05	3	150	2	24146905
Pubmed	Trypsin-mediated enzymatic degradation of type II collagen in the human vitreous.	PRSS1 PRSS2	5.53e-05	3	150	2	23882137
Pubmed	SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.	PACS1 SORL1	5.53e-05	3	150	2	24001769
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4D	5.53e-05	3	150	2	24555506
Pubmed	Null mutation of exocyst complex component 3-like does not affect vascular development in mice.	CSPG4 EXOC3L1	5.53e-05	3	150	2	37661429
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4D	5.53e-05	3	150	2	17404263
Pubmed	Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.	PRSS1 PRSS2	5.53e-05	3	150	2	26110235
Pubmed	Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.	PADI4 CXCR6	5.53e-05	3	150	2	27798616
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4D	5.53e-05	3	150	2	16034090
Pubmed	NVL: a new member of the AAA family of ATPases localized to the nucleus.	NVL VCP	5.53e-05	3	150	2	9286697
Pubmed	Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.	PF4 CXCR4	5.53e-05	3	150	2	10233851
Pubmed	Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls.	ABCA7 SORL1	5.53e-05	3	150	2	28789839
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4D	5.53e-05	3	150	2	15585880
Pubmed	Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway.	RNF103 VCP	5.53e-05	3	150	2	18675248
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4D	5.53e-05	3	150	2	10213096
Pubmed	ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.	MYO7B ANKS4B	5.53e-05	3	150	2	26812018
Pubmed	Gene conversion-like missense mutations in the human cationic trypsinogen gene and insights into the molecular evolution of the human trypsinogen family.	PRSS1 PRSS2	5.53e-05	3	150	2	11073713
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4D	5.53e-05	3	150	2	18508768
Pubmed	The origin of trypsin: evidence for multiple gene duplications in trypsins.	PRSS1 PRSS2	5.53e-05	3	150	2	9732462
Pubmed	Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.	PRSS1 PRSS2	5.53e-05	3	150	2	19077465
Pubmed	CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion.	PRSS1 PRSS2	5.53e-05	3	150	2	1763044
Pubmed	The RAIG family member, GPRC5D, is associated with hard-keratinized structures.	KRT33A KRT33B	5.53e-05	3	150	2	15086536
Pubmed	A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.	EPPK1 CTDSPL2 DSP	6.12e-05	18	150	3	26674342
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FREM1 FREM2 CSPG4	6.12e-05	18	150	3	14730302
Pubmed	Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.	SLC9A8 SLC9A4 SLC9A5	6.12e-05	18	150	3	24874739
Pubmed	An investigation into the human serum "interactome".	PRSS1 SLC9A8 CABLES1 IGDCC4 PHC3 FAM169A	7.66e-05	162	150	6	15174051
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL6A3 PF4 FREM1 FREM2 LPA CSPG4	9.05e-05	167	150	6	22159717
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	PRSS1 PCDHGA10 TAS1R3 NVL ITGA6 UBA1	9.36e-05	168	150	6	30631154
Pubmed	BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.	KRT33A KRT33B HSD17B1	9.88e-05	21	150	3	11013085
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	ITGA6 FREM1 FREM2	9.88e-05	21	150	3	27856617
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	GPAA1 CPS1 UGT1A3 SLC22A4	1.10e-04	57	150	4	21886157
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	PRSS1 EPPK1 DSP GALNT18 PHKA2 CEP250 MRPL41 HSPA7 VCP SORL1 PTCD3	1.10e-04	639	150	11	23443559
Pubmed	Expanding the clinical phenotype in patients with disease causing variants associated with atypical Usher syndrome.	ARSG CEP250	1.10e-04	4	150	2	34223797
Pubmed	Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.	CXCR4 LPA	1.10e-04	4	150	2	21719761
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FREM1 FREM2	1.10e-04	4	150	2	29618029
Pubmed	Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.	FREM1 FREM2	1.10e-04	4	150	2	23221805
Pubmed	Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.	PRSS1 PRSS2	1.10e-04	4	150	2	25253127
Pubmed	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.	FREM1 FREM2	1.10e-04	4	150	2	36495293
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4D	1.10e-04	4	150	2	21670503
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4D	1.10e-04	4	150	2	15644445
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FREM1 FREM2	1.10e-04	4	150	2	18563433
Pubmed	Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma.	CXCR6 CXCR4	1.10e-04	4	150	2	21527066
Pubmed	mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.	PDE4A PDE4D	1.10e-04	4	150	2	11296225
Pubmed	The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.	RASGRF2 VAV3	1.10e-04	4	150	2	20011522
Pubmed	Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.	A2M ABCA7	1.10e-04	4	150	2	34958020
Pubmed	cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor.	CXCR6 CXCR4	1.10e-04	4	150	2	11711593
Pubmed	Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.	PADI4 SLC22A4	1.10e-04	4	150	2	18087673
Pubmed	Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.	PRSS1 PRSS2	1.10e-04	4	150	2	33515547
Pubmed	Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease.	CXCR6 CXCR4	1.10e-04	4	150	2	10590105
Pubmed	SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.	PACS1 SORL1	1.10e-04	4	150	2	17855360
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4A PDE4D	1.10e-04	4	150	2	11839681
Pubmed	Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens.	PRSS1 PRSS2	1.10e-04	4	150	2	3011602
Pubmed	Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.	PADI4 SLC22A4	1.10e-04	4	150	2	15883854
Interaction	CEACAM8 interactions	CNTNAP3 ITGA6 ECE1 GALNT18 FREM2 CELSR3 PAM CACNA2D3	2.90e-06	119	149	8	int:CEACAM8
Cytoband	2p11.2	SUCLG1 RNF103 DNAH6 PTCD3	5.97e-05	64	150	4	2p11.2
Cytoband	8q24.3	EPPK1 GPAA1 BOP1 MFSD3	5.35e-04	113	150	4	8q24.3
Cytoband	5q31	PCDHGA10 PCDHB14 BRD8 PCDHGA12	5.71e-04	115	150	4	5q31
Cytoband	1p36.13	PADI4 ZBTB17 ARHGEF10L	8.35e-04	56	150	3	1p36.13
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 ARHGEF10L PLEKHG3 VAV3 DNMBP	2.63e-05	66	96	5	722
GeneFamily	Phosphodiesterases	PDE4A PDE4C PDE4D	2.71e-04	24	96	3	681
GeneFamily	CD molecules\|C-X-C motif chemokine receptors	CXCR6 CXCR4	4.13e-04	6	96	2	1094
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 DSP	7.65e-04	8	96	2	939
GeneFamily	BCL2 family	BOK BCL2L13	2.44e-03	14	96	2	1057
GeneFamily	Heat shock 70kDa proteins	HSPA13 HSPA7	3.60e-03	17	96	2	583
GeneFamily	Clustered protocadherins	PCDHGA10 PCDHB14 PCDHGA12	4.78e-03	64	96	3	20
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT16 GALNT18	4.98e-03	20	96	2	433
GeneFamily	Solute carriers	SLC9A8 SLC39A1 SLC4A1 SLC9A4 SLC9A5 SLC12A3 SLC22A4	5.08e-03	395	96	7	752
ToppCell	COVID-19-lung-Capillary_2\|lung / Disease (COVID-19 only), tissue and cell type	CNTNAP3B ANO2 RASGRF2 ITGA6 ECE1 RALGAPA2 GALNT18 EXOC3L1 ENG	2.47e-08	199	149	9	793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M CNTNAP3B ANO2 ITGA6 ECE1 GALNT18 EXOC3L1 ENG	2.41e-07	188	149	8	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CNTNAP3B DSP CNTNAP3 HID1 GALNT18 EXOC3L1 VAV3 BACE2	2.61e-07	190	149	8	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	A2M CNTNAP3B ANO2 RASGRF2 ITGA6 RALGAPA2 GALNT18 ENG	2.72e-07	191	149	8	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	CNTNAP3B ANO2 CNTNAP3 ECE1 RALGAPA2 BACE2 ENG PCDH7	2.83e-07	192	149	8	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 ECE1 RALGAPA2 FREM1 NHSL1 BACE2 ENG PCDH7	2.83e-07	192	149	8	14a816ef116aa992f86edab411f043cf7d07fe04
ToppCell	facs-Heart-LA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 ECE1 RALGAPA2 FREM1 NHSL1 BACE2 ENG PCDH7	2.83e-07	192	149	8	847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	CNTNAP3B ANO2 RASGRF2 RALGAPA2 VAV3 BACE2 ENG PCDH7	2.94e-07	193	149	8	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	CNTNAP3B ANO2 RASGRF2 ECE1 RALGAPA2 VAV3 BACE2 ENG	2.94e-07	193	149	8	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M BCAN HID1 ECE1 RALGAPA2 BACE2 ENG PCDH7	3.06e-07	194	149	8	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	A2M CNTNAP3B ANO2 RASGRF2 ITGA6 RALGAPA2 GALNT18 ENG	3.18e-07	195	149	8	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	A2M CNTNAP3B ANO2 RASGRF2 ITGA6 RALGAPA2 GALNT18 ENG	3.44e-07	197	149	8	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	A2M CNTNAP3B ANO2 RASGRF2 ITGA6 RALGAPA2 GALNT18	1.42e-06	165	149	7	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	MYO7B HID1 ANKS4B CABLES1 ACSM3 RNF103 DNAH6	1.74e-06	170	149	7	d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ANO2 MYO7B CPS1 FREM1 FREM2 UNC79	2.93e-06	184	149	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ANO2 MYO7B CPS1 FREM1 FREM2 UNC79	2.93e-06	184	149	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	PADI4 PDE4A ECE1 ACSL1 DENND10 DNMBP TM4SF20	2.93e-06	184	149	7	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ANO2 MYO7B CPS1 FREM1 FREM2 UNC79	2.93e-06	184	149	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	COVID-19-Endothelial_cells-Systemic_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	CNTNAP3B ANO2 RASGRF2 ITGA6 RALGAPA2 GALNT18 BACE2	3.04e-06	185	149	7	f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRF2 ITGA6 HID1 ECE1 GALNT18 EXOC3L1 ENG	3.15e-06	186	149	7	b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRF2 ITGA6 HID1 ECE1 GALNT18 EXOC3L1 ENG	3.15e-06	186	149	7	8a8ed1502542d4895cba3fd5d534256206578716
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	A2M CNTNAP3B ANO2 PDE4D RASGRF2 GALNT18 ENG	3.27e-06	187	149	7	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	CNTNAP3B ANO2 RASGRF2 ITGA6 ECE1 RALGAPA2 GALNT18	3.38e-06	188	149	7	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTNAP3B ANO2 CNTNAP3 ECE1 RALGAPA2 ENG PCDH7	3.50e-06	189	149	7	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CAND2 HID1 ECE1 BACE2 ENG PCDH7	3.50e-06	189	149	7	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRF2 ITGA6 HID1 GALNT18 EXOC3L1 FAM181B ENG	3.50e-06	189	149	7	2e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CAND2 HID1 ECE1 BACE2 ENG PCDH7	3.63e-06	190	149	7	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SYT17 ITGA6 FREM1 SLC4A1 SLC9A4 PCDH7	3.63e-06	190	149	7	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M HID1 ECE1 RALGAPA2 BACE2 ENG PCDH7	3.89e-06	192	149	7	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	A2M ANO2 RASGRF2 ITGA6 RALGAPA2 GALNT18 ENG	3.89e-06	192	149	7	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M CNTNAP3B ANO2 RASGRF2 ECE1 RALGAPA2 ENG	3.89e-06	192	149	7	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-Naive_B_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	MYO7B DSP SYT17 NFKBID FADS3 SGCE BACE2	4.02e-06	193	149	7	eb497d62a45ad77b2578b03a84cb3edc83207be5
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CNTNAP3B ANO2 ITGA6 ECE1 GALNT18 EXOC3L1 ENG	4.02e-06	193	149	7	ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCell	facs-Tongue-nan-3m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 DSP ARHGEF10L ACSL1 NHSL1 PLCD1 VPS53	4.02e-06	193	149	7	33437fdb417d78463caee14a9f0e094da1733829
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BAZ2B ITGA6 RALGAPA2 GALNT18 EXOC3L1 RIPOR1 VAV3	4.02e-06	193	149	7	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BAZ2B ITGA6 RALGAPA2 GALNT18 EXOC3L1 RIPOR1 VAV3	4.02e-06	193	149	7	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ANO2 RASGRF2 ITGA6 ECE1 RALGAPA2 GALNT18 EXOC3L1	4.02e-06	193	149	7	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D GALNT18 ARHGEF10L FREM2 CLCN5 VAV3 CACNA2D3	4.16e-06	194	149	7	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M CNTNAP3B ANO2 ITGA6 ECE1 GALNT18 ENG	4.16e-06	194	149	7	71ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	A2M CNTNAP3B ANO2 RASGRF2 ITGA6 GALNT18 ENG	4.30e-06	195	149	7	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M HID1 ECE1 RALGAPA2 BACE2 ENG PCDH7	4.30e-06	195	149	7	df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CNTNAP3B ANO2 RASGRF2 ECE1 GALNT18 ELFN1 ENG	4.45e-06	196	149	7	915e4a7422058be246b54760df31e8a607310625
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	CNTNAP3B ANO2 ITGA6 ECE1 RALGAPA2 GALNT18 ENG	4.60e-06	197	149	7	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_capillary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CNTNAP3B ANO2 ITGA6 ECE1 GALNT18 EXOC3L1 ENG	4.60e-06	197	149	7	81718164c9802ee20c860ffbda7e62d5e9a76f16
ToppCell	Control-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYO7B BAZ2B NFKBID ACSM3 CXCR4 EIF3L SGCE	4.60e-06	197	149	7	925bf0d38e4ce279fa45f455546ebd199282c0df
ToppCell	wk_15-18-Endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CNTNAP3 ITGA6 HID1 ECE1 GALNT18 EXOC3L1 ENG	4.76e-06	198	149	7	dcf453e22dba90c0ae349fa6c3d4c20758bb95af
ToppCell	COVID-19-lung-Capillary_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANO2 ITGA6 ECE1 RALGAPA2 GALNT18 EXOC3L1 ENG	4.76e-06	198	149	7	45419f2804b4be79bae6632e71c54e1af482d115
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CNTNAP3B ANO2 RASGRF2 ITGA6 ECE1 GALNT18 ENG	4.92e-06	199	149	7	e2d5c5cab102e67b0131b02392d81adaedc15965
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	PADI4 ANPEP BAZ2B CNTNAP3 ACSL1 PLEKHG3 SORL1	5.08e-06	200	149	7	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	severe-B_naive\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DSP SYT17 NFKBID FADS3 CXCR4 SGCE BACE2	5.08e-06	200	149	7	306df1f498ac2188eaf9f2a8d002bb73bdb9642d
ToppCell	Influenza_Severe-Neutrophil\|Influenza_Severe / Disease group and Cell class	CACNA1E CNTNAP3B MYO7B CNTNAP3 ACSL1 SORL1	1.72e-05	161	149	6	98c95b1b85d5427415af2ca8fb14849e97f6e8b5
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ECE1 RALGAPA2 BACE2 ENG PCDH7	2.19e-05	168	149	6	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ECE1 RALGAPA2 BACE2 ENG PCDH7	2.19e-05	168	149	6	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	Influenza_Severe-Neutrophil\|World / Disease group and Cell class	CACNA1E CNTNAP3B MYO7B CNTNAP3 ACSL1 SORL1	2.26e-05	169	149	6	6e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	MYO7B HID1 ANKS4B CABLES1 ACSM3 RNF103	2.42e-05	171	149	6	1af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M ANO2 CNTNAP3 GALNT18 EXOC3L1 ENG	2.42e-05	171	149	6	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RASGRF2 PCDHB14 GALNT18 BOK ENG	2.50e-05	172	149	6	a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	CNTNAP3B DSP CNTNAP3 HID1 VAV3 BACE2	2.58e-05	173	149	6	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	Mild/Remission-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYO7B BAZ2B NFKBID FADS3 CXCR4 ZBTB18	2.58e-05	173	149	6	694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ITGA6 ECE1 GALNT18 RIPOR1 ENG BCL2L13	2.67e-05	174	149	6	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	A2M BCAN HHATL ELFN1 CSPG4 SGCE	2.75e-05	175	149	6	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	A2M COL6A3 PCDHB14 BCAN IGDCC4 PCDH7	2.94e-05	177	149	6	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	A2M COL6A3 PCDHB14 BCAN IGDCC4 PCDH7	2.94e-05	177	149	6	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SYT17 ITGA6 SLC4A1 SLC9A4 PCDH7	2.94e-05	177	149	6	f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell	facs\|World / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 SLC39A1 DSP ITGA6 ECE1 NHSL1	3.13e-05	179	149	6	8001db3044e8657980e24422377c4fdb0d7b323e
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	A2M CNTNAP3B ANO2 RASGRF2 GALNT18 ENG	3.13e-05	179	149	6	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGEF10L CABLES1 CRACD CELSR3 SLC22A4 FAM169A	3.22e-05	180	149	6	c72f15763ba707189e29c85db533557f01c7fdb1
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	PRSS1 PRSS2 EPPK1 ECE1 GALNT16 CRACD	3.22e-05	180	149	6	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	ANO2 RASGRF2 ECE1 RALGAPA2 GALNT18 ENG	3.33e-05	181	149	6	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B CNTNAP3 HHATL CRACD PAM VAV3	3.43e-05	182	149	6	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP HID1 ARSG PTPRN2 BACE2 PRRC1	3.54e-05	183	149	6	5a936fb07074cec753bf19e3e3e52499605ea22c
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP HID1 ARSG PTPRN2 BACE2 PRRC1	3.54e-05	183	149	6	07c18ccc45ddc9c22e482bd9ffb87f46ebcfe473
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHB14 GALNT18 EXOC3L1 PLCD1 BACE2 ENG	3.76e-05	185	149	6	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	COPD-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	CNTNAP3B ANO2 RASGRF2 RALGAPA2 GALNT18 BACE2	3.76e-05	185	149	6	4abe04198ab5047c211f8d09cdb9650fa52a3cd6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SYT17 FREM1 SLC4A1 SLC9A4 PCDH7	3.76e-05	185	149	6	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRF2 ITGA6 ECE1 FADS3 BACE2 ENG	3.87e-05	186	149	6	9c7924875f70420720149287c500b4dfa8d24673
ToppCell	COPD-Endothelial-VE_Peribronchial\|COPD / Disease state, Lineage and Cell class	CNTNAP3B ANO2 RASGRF2 RALGAPA2 GALNT18 BACE2	3.87e-05	186	149	6	23c7d0e8372a71546d687278b985f761d282f92f
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	CNTNAP3B ANO2 RASGRF2 ECE1 ELFN1 ENG	3.87e-05	186	149	6	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CNTNAP3B PDE4D CRACD FREM2 CLCN5 VAV3	3.99e-05	187	149	6	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D SYT17 FREM1 SLC4A1 SLC9A4 PCDH7	3.99e-05	187	149	6	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 ITGA6 ECE1 FADS3 RIPOR1 ENG	4.11e-05	188	149	6	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	Control-Endothelial-VE_Peribronchial\|Control / Disease state, Lineage and Cell class	CNTNAP3B ANO2 RASGRF2 RALGAPA2 GALNT18 BACE2	4.11e-05	188	149	6	f5b7dbc89f992c13280d36a34935be83906b1bc0
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	CNTNAP3B ANO2 RASGRF2 ECE1 RALGAPA2 GALNT18	4.11e-05	188	149	6	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYT17 ITGA6 FREM1 SLC4A1 FAM169A BACE2	4.11e-05	188	149	6	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D FREM1 FREM2 VAV3 BACE2 UNC79	4.11e-05	188	149	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	Control-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	CNTNAP3B ANO2 RASGRF2 RALGAPA2 GALNT18 BACE2	4.23e-05	189	149	6	c76d8af2e0aa4a83ee0c3439c894566fbf117dd3
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CNTNAP3B RASGRF2 CNTNAP3 ITGA6 VAV3 DNMBP	4.23e-05	189	149	6	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CACNA1E HACD3 HID1 BACE2 PCDH7	4.23e-05	189	149	6	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	ANO2 ECE1 RALGAPA2 BACE2 ENG PCDH7	4.23e-05	189	149	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D GALNT18 FREM1 VAV3 BACE2 CACNA2D3	4.23e-05	189	149	6	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CACNA1E HACD3 HID1 BACE2 PCDH7	4.23e-05	189	149	6	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA6 GALNT18 EXOC3L1 RIPOR1 VAV3 BACE2	4.23e-05	189	149	6	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D ITGA6 FREM1 SLC4A1 SLC9A4 PCDH7	4.23e-05	189	149	6	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ITGA6 CABLES1 FREM2 ACSM3 VAV3 SORL1	4.36e-05	190	149	6	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 ITGA6 GBP3 ECE1 GALNT18 ENG	4.36e-05	190	149	6	5174f91a880f85bb20806023aa68bd4b8ca24ea5
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 ITGA6 GBP3 ECE1 GALNT18 ENG	4.36e-05	190	149	6	90e494cbfbed33a3a0d29bb7dae83f0c81580bcf
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PADI4 PDE4D ECE1 DENND10 CXCR4 DNMBP	4.36e-05	190	149	6	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	ANO2 RASGRF2 ITGA6 ECE1 RALGAPA2 GALNT18	4.36e-05	190	149	6	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 ITGA6 GBP3 ECE1 GALNT18 ENG	4.36e-05	190	149	6	c8370c922e0cf0e0c36e02e1ed2b4053ad6a8073
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	A2M ANO2 RASGRF2 ITGA6 GALNT18 GPAT2	4.36e-05	190	149	6	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
Drug	Piclamilast	PDE4A PDE4C PDE4D	1.09e-06	4	149	3	DB01791
Drug	NSC-694280	A2M PRSS1 PRSS2 ANPEP ECE1 CXCR4 NMBR BACE2	1.94e-06	127	149	8	CID000004802
Drug	Ibudilast	PDE4A PDE4C PDE4D	2.72e-06	5	149	3	DB05266
Drug	1,7-naphthyridine	PDE4A PDE4C PDE4D	2.72e-06	5	149	3	CID000009209
Drug	Ketotifen	PDE4A PDE4C PDE4D	9.43e-06	7	149	3	DB00920
Drug	Iloprost	PDE4A PDE4C PDE4D	9.43e-06	7	149	3	DB01088
Drug	leupeptins	A2M PRSS1 PRSS2	9.43e-06	7	149	3	CID003033938
Drug	C4 m	A2M PRSS1 PRSS2 PADI4 PF4 SLC4A1	1.33e-05	79	149	6	CID009543487
Drug	Dyphylline	PDE4A PDE4C PDE4D	1.50e-05	8	149	3	DB00651
Drug	Boc hydrazine	PRSS1 PRSS2 ANPEP	1.50e-05	8	149	3	CID000070091
Drug	APMSF	PRSS1 PRSS2 ANPEP PF4 ECE1	1.53e-05	48	149	5	CID000001719
Drug	N-acetylimidazole	PRSS1 PRSS2 ANPEP BACE2	1.69e-05	24	149	4	CID000017174
Drug	p-nitrophenylalanine	ANPEP ECE1 BACE2 ENG	2.00e-05	25	149	4	CID000013706
Drug	trequinsin	PDE4A PDE4C PDE4D	2.24e-05	9	149	3	ctd:C035964
Drug	L-826,141	PDE4A PDE4C PDE4D	2.24e-05	9	149	3	ctd:C459562
Drug	T-440	PDE4A PDE4C PDE4D PTPRN2	2.35e-05	26	149	4	CID000177965
Drug	NVP ABE171	PDE4A PDE4C PDE4D	3.19e-05	10	149	3	ctd:C451724
Drug	MUGB	PRSS1 PRSS2 ANPEP	3.19e-05	10	149	3	CID000134454
Drug	lys-val	PRSS1 PRSS2 SLC4A1	3.19e-05	10	149	3	CID000140709
Drug	EIPA	SLC9A8 DCTN1 SLC4A1 SLC9A5 BOK PAM	3.82e-05	95	149	6	CID000001795
Drug	(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one	PDE4A PDE4D	4.25e-05	2	149	2	DB06842
Drug	26-nor-25-doxylcholestanol	PRSS1 PRSS2 SLC4A1	4.36e-05	11	149	3	CID000125890
Drug	AC1LASJR	A2M PRSS1 PRSS2 LPA SGCE	4.59e-05	60	149	5	CID000474231
Drug	Methoxamine hydrochloride [61-16-5]; Down 200; 16.2uM; HL60; HT_HG-U133A	PDE4C MFAP3 ACSM3 FADS3 PTPRN2 RIPOR1 PLCD1 VPS53	4.62e-05	196	149	8	2488_DN
Drug	imidazole-4-carboxamide	PDE4A PDE4C PDE4D SLC4A1	5.49e-05	32	149	4	CID000152917
Drug	5-amidinoindole	PRSS1 PRSS2 TRRAP	5.79e-05	12	149	3	CID000122670
Drug	chondroitin sulfate	A2M PRSS1 COL6A3 PRSS2 EPYC PF4 BCAN ARSG UGT1A3 CSPG4 UGT2B4	9.01e-05	413	149	11	CID000024766
Drug	2-aminothiophenol	PRSS1 PRSS2 ACSM3	9.48e-05	14	149	3	CID000008713
Drug	Pro-arg	PRSS1 PRSS2 ANPEP ENG	9.83e-05	37	149	4	CID000151004
Drug	BTPNA	PRSS1 PRSS2 ANPEP	1.18e-04	15	149	3	CID000188992
Drug	N-allylglycine	PRSS1 PRSS2	1.27e-04	3	149	2	CID000076651
Drug	N-acetyl-L-norvaline methyl ester	PRSS1 PRSS2	1.27e-04	3	149	2	CID000150916
Drug	YAKR-CK	PRSS1 PRSS2	1.27e-04	3	149	2	CID005487256
Drug	2 alpha-bromoacetoxyprogesterone	PRSS1 PRSS2	1.27e-04	3	149	2	CID000135256
Drug	Chi 2	PF4 CXCR4	1.27e-04	3	149	2	CID000063720
Drug	methyl lignocerate	PRSS1 PRSS2	1.27e-04	3	149	2	CID000075546
Drug	GB-107	PRSS1 PRSS2	1.27e-04	3	149	2	CID000056813
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4A PDE4D	1.27e-04	3	149	2	DB08299
Drug	mitorubrinic acid	PRSS1 PRSS2	1.27e-04	3	149	2	CID000379537
Drug	gentisuric acid	SLC4A1 PAM	1.27e-04	3	149	2	CID000161488
Drug	ASA-PE	PRSS1 PRSS2	1.27e-04	3	149	2	CID003037809
Drug	schizopeptin 791	PRSS1 PRSS2	1.27e-04	3	149	2	CID000636821
Drug	Lapg-nh2	PRSS1 PRSS2	1.27e-04	3	149	2	CID003082486
Drug	Methotrexate-polylysine	PRSS1 PRSS2	1.27e-04	3	149	2	CID000163214
Drug	methyl octanesulfonate	PRSS1 PRSS2	1.27e-04	3	149	2	CID000165858
Drug	3HFGB	PRSS1 PRSS2	1.27e-04	3	149	2	CID000126268
Drug	4-chlorobenzenediazonium hexafluorophosphate	PRSS1 PRSS2	1.27e-04	3	149	2	CID002723983
Drug	10-(carboxyethyl)flavin	PRSS1 PRSS2	1.27e-04	3	149	2	CID003082170
Drug	Z-Lys-CH2Cl	PRSS1 PRSS2	1.27e-04	3	149	2	CID000127335
Drug	2,6-dimethyl-3-pyridinol	PRSS1 PRSS2	1.27e-04	3	149	2	CID000070732
Drug	N-phosphopyridoxyl-L-serine	PRSS1 PRSS2	1.27e-04	3	149	2	CID000195946
Drug	Z-Arg-OH	PRSS1 PRSS2	1.27e-04	3	149	2	CID000071055
Drug	p-amidinophenylpyruvate	PRSS1 PRSS2	1.27e-04	3	149	2	CID000444106
Drug	v 1194	PRSS1 PRSS2	1.27e-04	3	149	2	CID000074702
Drug	L-TAPA	PRSS1 PRSS2	1.27e-04	3	149	2	CID000193734
Drug	S 2251	A2M PRSS1 PRSS2 LPA	1.34e-04	40	149	4	CID000124997
Drug	Roflumilast	PDE4A PDE4C PDE4D	1.44e-04	16	149	3	ctd:C424423
Drug	AC1LAR7G	A2M PRSS1 PRSS2 ANPEP	1.48e-04	41	149	4	CID000493598
Drug	nafamostat mesilate	A2M PRSS1 PRSS2 PTPRN2 VCP	1.52e-04	77	149	5	CID000004413
Drug	8-azaguanine	COL6A3 BCAN UGT1A3 CSPG4 UGT2B4	1.61e-04	78	149	5	CID000008646
Drug	AC1L1D3F	DCTN1 CXCR4 CSPG4 UROD BACE2	1.71e-04	79	149	5	CID000002177
Drug	Tosylarginine Methyl Ester	A2M PRSS1 PRSS2	1.75e-04	17	149	3	CID000013481
Drug	Sesquimustard	ANPEP SLC4A1 BOK PAM	1.78e-04	43	149	4	CID000019092
Disease	Marles Greenberg Persaud syndrome	FREM1 FREM2	2.33e-05	2	143	2	C1855425
Disease	congestive heart failure (implicated_via_orthology)	ECE1 CXCR4 PLCD1 ENG	4.66e-05	41	143	4	DOID:6000 (implicated_via_orthology)
Disease	Global developmental delay	CACNA1E GPAA1 TRRAP DHPS ZBTB18 VPS53	4.82e-05	133	143	6	C0557874
Disease	Nephritis, Tubulointerstitial	SLC4A1 SLC12A3 CLCN5	1.39e-04	21	143	3	C0041349
Disease	Renal tubular acidosis	SLC4A1 SLC12A3	1.39e-04	4	143	2	C0001126
Disease	Fraser syndrome (implicated_via_orthology)	FREM1 FREM2	1.39e-04	4	143	2	DOID:0090001 (implicated_via_orthology)
Disease	Limb dystonia	ARSG CACNA2D3	1.39e-04	4	143	2	Orphanet_93957
Disease	Nephritis, Interstitial	SLC4A1 SLC12A3 CLCN5	2.09e-04	24	143	3	C0027707
Disease	nephrotic syndrome (biomarker_via_orthology)	A2M ACAT1 ECE1	2.09e-04	24	143	3	DOID:1184 (biomarker_via_orthology)
Disease	PANCREATITIS, HEREDITARY	PRSS1 PRSS2	2.31e-04	5	143	2	167800
Disease	nephrolithiasis (implicated_via_orthology)	SLC9A4 SLC9A5	2.31e-04	5	143	2	DOID:585 (implicated_via_orthology)
Disease	Hereditary pancreatitis	PRSS1 PRSS2	2.31e-04	5	143	2	cv:C0238339
Disease	Autosomal Dominant Hereditary Pancreatitis	PRSS1 PRSS2	2.31e-04	5	143	2	C4080064
Disease	Hereditary pancreatitis	PRSS1 PRSS2	4.82e-04	7	143	2	C0238339
Disease	Unilateral agenesis of kidney	FREM1 FREM2	6.41e-04	8	143	2	C0266294
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP3B CNTNAP3	6.41e-04	8	143	2	DOID:0060308 (implicated_via_orthology)
Disease	response to methylphenidate	RASGRF2 PTCD3	8.21e-04	9	143	2	GO_0036271
Disease	Pancreatitis, Chronic	PRSS1 PRSS2	8.21e-04	9	143	2	C0149521
Disease	X-21467 measurement	CPS1 DNMBP	8.21e-04	9	143	2	EFO_0020007
Disease	docosahexaenoic acid measurement, fatty acid measurement	CXCR4 LPA SLC22A4	9.66e-04	40	143	3	EFO_0005110, EFO_0007761
Disease	aspartate aminotransferase to alanine aminotransferase ratio	PDE4C EPPK1 ANPEP DNMBP MFSD3 TMEM236	1.13e-03	239	143	6	EFO_0010934
Disease	histidine betaine (hercynine) measurement	UGT1A3 SLC22A4	1.25e-03	11	143	2	EFO_0800972
Disease	renal fibrosis (biomarker_via_orthology)	ECE1 ENG	1.49e-03	12	143	2	DOID:0050855 (biomarker_via_orthology)
Disease	retinol dehydrogenase 16 measurement	PF4 UGT1A3	1.76e-03	13	143	2	EFO_0802007
Disease	mouth morphology measurement	NHLRC2 GALNT18 PCDH7	1.85e-03	50	143	3	EFO_0007955
Disease	gallstones	ANPEP HID1 CPS1 UGT1A3	1.92e-03	108	143	4	EFO_0004210
Disease	early cardiac repolarization measurement	SLC9A8 PAM	2.04e-03	14	143	2	EFO_0004885
Disease	generalised epilepsy	PADI4 CDK5RAP3 PCDH7	2.07e-03	52	143	3	EFO_0005917
Disease	IGA glomerulonephritis	PADI4 VAV3 SORL1	2.83e-03	58	143	3	EFO_0004194
Disease	Amyotrophic lateral sclerosis	DCTN1 VCP	3.02e-03	17	143	2	cv:C0002736
Disease	essential hypertension (is_implicated_in)	ECE1 SLC12A3	3.39e-03	18	143	2	DOID:10825 (is_implicated_in)
Disease	phosphatidylcholine 36:4 measurement	FADS3 UGT2B4	3.39e-03	18	143	2	EFO_0010382
Disease	cerebral infarction (is_marker_for)	A2M LPA	3.78e-03	19	143	2	DOID:3526 (is_marker_for)
Disease	Alzheimer's disease (is_implicated_in)	A2M ECE1 BACE2 SORL1	3.96e-03	132	143	4	DOID:10652 (is_implicated_in)
Disease	coronary artery disease (is_marker_for)	ECE1 LPA ENG	4.26e-03	67	143	3	DOID:3393 (is_marker_for)
Disease	Seizures	CACNA1E ACAT1 TRRAP DHPS PAM	4.28e-03	218	143	5	C0036572
Disease	stroke, coronary artery disease	PEMT LPA	4.61e-03	21	143	2	EFO_0000712, EFO_0001645
Disease	docosahexaenoic acid to total fatty acids percentage	LPA SLC22A4	4.61e-03	21	143	2	EFO_0022262

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDVVLTDPVNLCAAV	UGT1A3	146	P35503
EAAVASVVLPARELQ	BCL2L13	321	Q9BXK5
VAAAVEDSVLLLNPA	BOP1	471	Q14137
VALPVELATAEALVA	EXOC3L1	281	Q86VI1
VFVNLAESEITIAPL	DENND10P1	251	Q6NSW5
FDAVVEAVARASLIP	BACE2	316	Q9Y5Z0
VAFLAVATSILAPDI	ARHGEF10L	1116	Q9HCE6
DDTAVQPLVAVLIDS	CNTNAP3	471	Q9BZ76
AADAILTVTPAAAVL	ELFN1	676	P0C7U0
LEDAALTFPVLFQDV	CTDSPL2	306	Q05D32
LLTIPDFIFANVSEA	CXCR4	166	P61073
TDVFLVNLPLADLVF	CXCR6	66	O00574
PVATALTDIDLQLQF	CSPG4	41	Q6UVK1
LVIAASSIALAAEDP	CACNA1E	1161	Q15878
LQEVAAAAAQLIAPL	DCTN1	841	Q14203
DITDAFSPQVLAAVI	SLC4A1	396	P02730
PEVLDVAAVEAALSF	BRD8	431	Q9H0E9
ESLQAFLIAIVVPDV	ACSL1	591	P33121
VLGFDVNIDVPNLSV	BAZ2B	1106	Q9UIF8
PSIIFFDELDALAVE	SPATA5	721	Q8NB90
DPLAIAVQAANADIV	ACAP3	771	Q96P50
EDTILVIDPNNAAVL	PAM	556	P19021
LDIFPTVVALAQASL	ARSG	366	Q96EG1
LLAALEISDAVGPVF	DNMBP	841	Q6XZF7
EINTPAQISELFDAI	ANPEP	461	P15144
ISNAFVIAITSDFIP	ANO2	816	Q9NQ90
LQSEPVVTDAFLAVA	BOK	96	Q9UMX3
LNASIVASFVELPLA	ENG	306	P17813
TALALVGDPAVVFLD	ABCA7	1936	Q8IZY2
VQLEASPAFLAVPVE	A2M	826	P01023
PEVVNVDNLLAAAVV	C18orf25	256	Q96B23
PANLIQEIILVDDFS	GALNT16	151	Q8N428
AAELRVLAAPAITQA	IGDCC4	326	Q8TDY8
AINTDIDVLPVNFAL	RC3H2	56	Q9HBD1
IELNDFIVALSSVQP	NVL	551	O15381
TVAVADSIPQVLADL	PCDHGA12	661	O60330
LLQVPSSAFADVEVL	PTPRN2	536	Q92932
LLDTSNLELPEAVVF	PADI4	271	Q9UM07
ALVLAQAPAALADVL	BCAN	11	Q96GW7
FPLDAAIIFSDILVV	UROD	76	P06132
QAIEVVELASAFSLP	PTCD3	626	Q96EY7
NPITVADNIIDAIVD	PARP15	416	Q460N3
LSAFQPDVVIAADVL	FAM86B2	236	P0C5J1
SVLLAVPEAVFSEVA	NMBR	171	P28336
AVIPELAATVATFAI	HHATL	361	Q9HCP6
FPVAEAEAVVLTLLA	GPAA1	456	O43292
LAEAVSVIQSIPIFN	HACD3	291	Q9P035
ASAEIQLLAAIEAPA	FSCB	521	Q5H9T9
EAIAPQVGNDAVFLI	EIF3L	116	Q9Y262
VAAAANQPLIVEDLL	NFKBID	91	Q8NI38
LVIDTPILNAADADV	FREM2	1206	Q5SZK8
ETFQVVLSEPVLAAL	FREM2	1851	Q5SZK8
FAVEPAENVSEALRA	NHSL1	1216	Q5SYE7
LVIFDAAVTAPTLES	EPYC	11	Q99645
QLSAFQPDVVIAADV	FAM86B1	201	Q8N7N1
VAVADSIPQVLADLG	PCDHGA10	666	Q9Y5H3
NVAEDVLVDTPIALV	PCDH7	431	O60245
AHAEDLIVTPFAQVL	PDE4A	171	P27815
TPALDAVFTDLEILA	PDE4A	451	P27815
TPALEAVFTDLEILA	PDE4C	406	Q08493
PALEAVFTDLEILAA	PDE4D	481	Q08499
LSAFQPDVVIAADVL	EEF2KMT	236	Q96G04
NFAIDLIAEQPVSEV	NDUFS6	66	O75380
ISAVDLDIPQDALLF	FREM1	1171	Q5H8C1
VEVDAAPTVDLNQVL	KRT33A	211	O76009
DIAQIPAAQVSLVLF	MFSD2B	71	A6NFX1
SALLQVIFSPLEEEV	GBP3	406	Q9H0R5
DVVDATPLEVFLLSQ	ANKS4B	341	Q8N8V4
AFIDVTAAAENIRLP	ITGA6	1016	P23229
TEAAVLLAAEPLDVF	FAM181B	276	A6NEQ2
EILVATVAFLLPSAE	RALGAPA2	1231	Q2PPJ7
DVALDALAVQLLEPA	MFSD3	116	Q96ES6
VLVQNALVSEEELPA	PHC3	536	Q8NDX5
LDIPVAVTIFFGAND	IAH1	76	Q2TAA2
VSVLPIFRSENAVVD	NHLRC2	566	Q8NBF2
VLPIINEATAAAIAY	HSPA7	171	P48741
VASIIVPAAFVLEDV	MFAP3	11	P55082
LVSDAALPENVILVN	PACS1	556	Q6VY07
LDPSFVAAVITITFN	PEMT	11	Q9UBM1
TEFAFEVVVPDLALI	PLCD1	686	P51178
EDIFVTPISNLVANI	FBXO43	296	Q4G163
IPENASETLVALFSI	PCDHB14	356	Q9Y5E9
VRAEQIVPLSAASFE	ATR	1826	Q13535
IFSAVLDELKVAQAP	CPS1	1091	P31327
LFEVQDLRVASPATV	DNAH6	1876	Q9C0G6
DDAFISVQVPAAAFL	CABLES1	211	Q8TDN4
IQEVLFDAVVSAPIE	CACNA2D3	691	Q8IZS8
VVTDAALAFLAEAPA	GAS2L2	71	Q8NHY3
AQNPEEVAEVFLTAL	HSD17B1	231	P14061
ADASLVFPLLVAETF	DHPS	341	P49366
DVLSVSQFQLAPAIL	CDK5RAP3	376	Q96JB5
TIESVNLDAIPLAIA	CRACD	136	Q6ZU35
LLEAQAATGFIVDPV	DSP	2291	P15924
LVVTAITAILAFPNE	CLCN5	431	P51795
AELEQIVLSPAFILA	COL6A3	981	P12111
LAVAQAPEATVLEAE	CEP250	2396	Q9BV73
QLSAELLPVFLSEAV	GPAT2	541	Q6NUI2
DSLPEVSIVFIFVNE	GALNT18	151	Q6P9A2
ILAPSLEAFFEQALT	LPA	1031	P08519
ILALFAPEDSLTAVA	FAM169A	66	Q9Y6X4
DLPAFVSVVANEAKL	ASNSD1	221	Q9NWL6
PVANAVISVPAEFDL	HSPA13	166	P48723
QILDFETALANITIP	ECE1	306	P42892
AVLATPAEDVFIFNI	CELSR3	1301	Q9NYQ7
AVQAVLAELPALVNE	CAND2	691	O75155
VPSALAAFILAISQA	FADS3	161	Q9Y5Q0
VFVNLAESEITIAPL	DENND10	251	Q8TCE6
PEVNDLFVLSLVLVN	RNF103	321	O00237
IAVPAVIFDSVEELN	SLC22A4	306	Q9H015
DDTAVQPLVAVLIDS	CNTNAP3B	471	Q96NU0
SIISFPAFAVEDVNL	PHKA2	261	P46019
LTAAQLFSEAVAPAI	MRPL41	86	Q8IXM3
LETVEALAFEPLSQL	SORL1	831	Q92673
EASVDLVQIPQAEAL	TAPBPL	96	Q9BX59
VPQEELENASLVFTV	SYT17	396	Q9BSW7
ATVTQDRAFPLVVAE	TMEM132E	761	Q6IEE7
LEVPADSRVFVQAAL	TGFBR3L	81	H3BV60
PSVLDQASVIAERFV	PLEKHG3	596	A1L390
VEPPDAAAFTVVLLA	RASGRF2	556	O14827
DPAVDALTSIVVLAA	PRR23B	51	Q6ZRT6
TSVQDVFALVPAAEI	HID1	41	Q8IV36
VLLEAQAATGFVIDP	EPPK1	2261	P58107
VLLEAQAATGFVIDP	EPPK1	4396	P58107
SLISAVDPVAVLAVF	SLC9A4	201	Q6AI14
LISAVDPVATIAIFN	SLC9A8	196	Q9Y2E8
ISAVDPVAVLAVFEE	SLC9A5	181	Q14940
QTAVSVENFIAELLP	PRRC1	326	Q96M27
VTPLARIVAFADAAV	ACAT1	306	P24752
ILLSATVPNALEFAD	SKIV2L	451	Q15477
DFLITLAVPSAVALV	SGCE	316	O43556
AAAINEAIEAEIPLV	SUCLG1	126	P53597
NAIPLIVSLVEEDQF	TM4SF20	26	Q53R12
IITNDVLAPAVDAVA	ACSM3	171	Q53FZ2
DIVEIPLELQFSSVA	STK31	126	Q9BXU1
LSELAAETDLPVVFV	TXNRD1	111	Q16881
EELLSLAVQIQPDFA	TMTC4	536	Q5T4D3
LFLQAAEIFVESELP	TAS1R3	651	Q7RTX0
NAPAIIFIDELDAIA	VCP	296	P55072
QESRFDVVLADAVFP	UGT2B4	141	P06133
IDEALAALHVTLQFP	SLC39A1	96	Q9NY26
NSDIVTAPAFALLLE	ZBTB18	66	Q99592
AVAFIIIAELNTIAP	SLC12A3	516	P55017
ILTFVAAAVAAPFDD	PRSS2	6	P07478
LVASLAEPDFVVTDF	UBA1	306	P22314
LFPTEQSLANIDEVV	VPS53	51	Q5VIR6
LLPLVVAFASAEAEE	PF4	21	P02776
PENVDDVLAVATFLQ	ZBTB17	86	Q13105
ILTFVAAALAAPFDD	PRSS1	6	P07477
TKDLFAALPQVVAVD	RIPOR1	291	Q6ZS17
GEVALAVIFDVASII	TRRAP	1111	Q9Y4A5
EFAAFSIPTLVITEQ	TMEM236	16	Q5W0B7
IDASVVSPEEFALLL	ZBTB40	61	Q9NUA8
FLTAVEDVNPAVATR	UNC79	1096	Q9P2D8
LTAAEFDSVFINIPE	VAV3	226	Q9UKW4
VEVDAAPAVDLNQVL	KRT33B	211	Q14525
VSPSSVAIAELVALF	MYO7B	1481	Q6PIF6