Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Spectrin/alpha-actinin	EVPLL SPTAN1 EVPL DMD UTRN	1.73e-08	32	48	5	IPR018159
Domain	SPEC	EVPLL SPTAN1 EVPL DMD UTRN	1.73e-08	32	48	5	SM00150
Domain	Spectrin_repeat	SPTAN1 EVPL DMD UTRN	8.70e-07	29	48	4	IPR002017
Domain	Envoplakin	EVPLL EVPL	6.47e-06	2	48	2	IPR030460
Domain	Dystrophin	DMD UTRN	6.47e-06	2	48	2	IPR016344
Domain	Spectrin	SPTAN1 DMD UTRN	2.72e-05	23	48	3	PF00435
Domain	EF-hand_dom_typ1	DMD UTRN	9.64e-05	6	48	2	IPR015153
Domain	EF-hand_dom_typ2	DMD UTRN	9.64e-05	6	48	2	IPR015154
Domain	EF-hand_2	DMD UTRN	9.64e-05	6	48	2	PF09068
Domain	EF-hand_3	DMD UTRN	9.64e-05	6	48	2	PF09069
Domain	WW	ITCH DMD UTRN	2.39e-04	47	48	3	PF00397
Domain	WW	ITCH DMD UTRN	2.54e-04	48	48	3	SM00456
Domain	WW_DOMAIN_2	ITCH DMD UTRN	3.04e-04	51	48	3	PS50020
Domain	WW_DOMAIN_1	ITCH DMD UTRN	3.04e-04	51	48	3	PS01159
Domain	WW_dom	ITCH DMD UTRN	3.22e-04	52	48	3	IPR001202
Domain	-	HSPA2 HSPA4	4.20e-04	12	48	2	2.60.34.10
Domain	HSP70_peptide-bd	HSPA2 HSPA4	4.20e-04	12	48	2	IPR029047
Domain	-	HSPA2 HSPA4	4.95e-04	13	48	2	1.20.1270.10
Domain	Heat_shock_70_CS	HSPA2 HSPA4	4.95e-04	13	48	2	IPR018181
Domain	HSP70_C	HSPA2 HSPA4	4.95e-04	13	48	2	IPR029048
Domain	HSP70	HSPA2 HSPA4	7.58e-04	16	48	2	PF00012
Domain	HSP70_2	HSPA2 HSPA4	8.58e-04	17	48	2	PS00329
Domain	HSP70_3	HSPA2 HSPA4	8.58e-04	17	48	2	PS01036
Domain	HSP70_1	HSPA2 HSPA4	8.58e-04	17	48	2	PS00297
Domain	ZZ	DMD UTRN	9.64e-04	18	48	2	PF00569
Domain	ZF_ZZ_2	DMD UTRN	9.64e-04	18	48	2	PS50135
Domain	ZF_ZZ_1	DMD UTRN	9.64e-04	18	48	2	PS01357
Domain	Hsp_70_fam	HSPA2 HSPA4	9.64e-04	18	48	2	IPR013126
Domain	Znf_ZZ	DMD UTRN	1.08e-03	19	48	2	IPR000433
Domain	ZnF_ZZ	DMD UTRN	1.08e-03	19	48	2	SM00291
Domain	Actinin_actin-bd_CS	DMD UTRN	1.58e-03	23	48	2	IPR001589
Domain	ACTININ_2	DMD UTRN	1.58e-03	23	48	2	PS00020
Domain	ACTININ_1	DMD UTRN	1.58e-03	23	48	2	PS00019
Domain	Pkinase_Tyr	ERBB2 EPHA2 MAP3K20	4.44e-03	129	48	3	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB2 EPHA2 MAP3K20	5.35e-03	138	48	3	IPR001245
Domain	Rossmann-like_a/b/a_fold	IARS1 DPH6	5.46e-03	43	48	2	IPR014729
Domain	-	IARS1 DPH6	5.46e-03	43	48	2	3.40.50.620
Pubmed	Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.	DMD UTRN HSPA2	1.86e-07	8	53	3	22495301
Pubmed	Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	10525423
Pubmed	Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils.	DMD UTRN	2.28e-06	2	53	2	20434517
Pubmed	Plasma lipidomic analysis shows a disease progression signature in mdx mice.	DMD UTRN	2.28e-06	2	53	2	34155298
Pubmed	In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.	DMD UTRN	2.28e-06	2	53	2	28790199
Pubmed	Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.	DMD UTRN	2.28e-06	2	53	2	24466085
Pubmed	Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity.	ERBB2 FCGR2A	2.28e-06	2	53	2	23030766
Pubmed	The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.	DMD UTRN	2.28e-06	2	53	2	27110493
Pubmed	Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.	DMD UTRN	2.28e-06	2	53	2	24781208
Pubmed	Isolation and characterization of a genomic clone from the murine utrophin locus.	DMD UTRN	2.28e-06	2	53	2	8268660
Pubmed	Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	25859846
Pubmed	G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.	DMD UTRN	2.28e-06	2	53	2	7731967
Pubmed	Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.	DMD UTRN	2.28e-06	2	53	2	27037492
Pubmed	Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.	DMD UTRN	2.28e-06	2	53	2	16710609
Pubmed	Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.	DMD UTRN	2.28e-06	2	53	2	16487708
Pubmed	Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.	DMD UTRN	2.28e-06	2	53	2	30672725
Pubmed	Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.	DMD UTRN	2.28e-06	2	53	2	21677768
Pubmed	Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.	DMD UTRN	2.28e-06	2	53	2	7962191
Pubmed	Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse.	DMD UTRN	2.28e-06	2	53	2	9713852
Pubmed	Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	25607927
Pubmed	Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?	DMD UTRN	2.28e-06	2	53	2	8021701
Pubmed	Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.	DMD UTRN	2.28e-06	2	53	2	26974331
Pubmed	Developmental studies of dystrophin-positive fibers in mdx, and DRP localization.	DMD UTRN	2.28e-06	2	53	2	8433092
Pubmed	Second-generation compound for the modulation of utrophin in the therapy of DMD.	DMD UTRN	2.28e-06	2	53	2	25935002
Pubmed	Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.	DMD UTRN	2.28e-06	2	53	2	16024571
Pubmed	Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	28453658
Pubmed	A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.	DMD UTRN	2.28e-06	2	53	2	11801396
Pubmed	Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines.	DMD UTRN	2.28e-06	2	53	2	7987307
Pubmed	Utility of dystrophin and utrophin staining in childhood muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	16295426
Pubmed	Comparative analysis of the human dystrophin and utrophin gene structures.	DMD UTRN	2.28e-06	2	53	2	11861579
Pubmed	Distinct mechanical properties in homologous spectrin-like repeats of utrophin.	DMD UTRN	2.28e-06	2	53	2	30914715
Pubmed	Dystrophin is a microtubule-associated protein.	DMD UTRN	2.28e-06	2	53	2	19651889
Pubmed	Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice.	DMD UTRN	2.28e-06	2	53	2	9590295
Pubmed	Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains.	DMD UTRN	2.28e-06	2	53	2	22284942
Pubmed	Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.	DMD UTRN	2.28e-06	2	53	2	29879154
Pubmed	Frameshift Mutations of HSPA4 and MED13 in Gastric and Colorectal Cancers.	HSPA4 MED13	2.28e-06	2	53	2	27129500
Pubmed	Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.	DMD UTRN	2.28e-06	2	53	2	17889902
Pubmed	Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion.	DMD UTRN	2.28e-06	2	53	2	12370193
Pubmed	Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models.	DMD UTRN	2.28e-06	2	53	2	32025735
Pubmed	Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.	DMD UTRN	2.28e-06	2	53	2	27836895
Pubmed	BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.	DMD UTRN	2.28e-06	2	53	2	27750047
Pubmed	Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression.	DMD UTRN	2.28e-06	2	53	2	17967782
Pubmed	Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.	DMD UTRN	2.28e-06	2	53	2	21062902
Pubmed	Matricellular Protein CCN5 Gene Transfer Ameliorates Cardiac and Skeletal Dysfunction in mdx/utrn (±) Haploinsufficient Mice by Reducing Fibrosis and Upregulating Utrophin Expression.	DMD UTRN	2.28e-06	2	53	2	35557546
Pubmed	Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.	DMD UTRN	2.28e-06	2	53	2	37626761
Pubmed	Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.	ITCH SPART	2.28e-06	2	53	2	38503285
Pubmed	Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.	DMD UTRN	2.28e-06	2	53	2	15565469
Pubmed	The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.	DMD UTRN	2.28e-06	2	53	2	26516677
Pubmed	Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.	DMD UTRN	2.28e-06	2	53	2	22209498
Pubmed	The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.	ERBB2 EPHA2	2.28e-06	2	53	2	18079969
Pubmed	A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.	DMD UTRN	2.28e-06	2	53	2	37108685
Pubmed	Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.	DMD UTRN	2.28e-06	2	53	2	10694796
Pubmed	Dystrophin and dystrophin-related protein in the central nervous system of normal controls and Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	8171962
Pubmed	Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.	DMD UTRN	2.28e-06	2	53	2	27822449
Pubmed	Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model.	DMD UTRN	2.28e-06	2	53	2	33651713
Pubmed	Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.	DMD UTRN	2.28e-06	2	53	2	22275054
Pubmed	NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.	DMD UTRN	2.28e-06	2	53	2	27798264
Pubmed	Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes.	OPN4 DMD	2.28e-06	2	53	2	19783774
Pubmed	Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice.	DMD UTRN	2.28e-06	2	53	2	31506484
Pubmed	Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	9288752
Pubmed	Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	9288751
Pubmed	Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.	DMD UTRN	2.28e-06	2	53	2	24337461
Pubmed	Combined gene therapy via VEGF and mini-dystrophin synergistically improves pathologies in temporalis muscle of dystrophin/utrophin double knockout mice.	DMD UTRN	2.28e-06	2	53	2	33987645
Pubmed	Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice.	DMD UTRN	2.28e-06	2	53	2	11297940
Pubmed	Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice.	DMD UTRN	2.28e-06	2	53	2	29408646
Pubmed	Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.	DMD UTRN	2.28e-06	2	53	2	22388933
Pubmed	Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.	DMD UTRN	2.28e-06	2	53	2	25642938
Pubmed	Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice.	DMD UTRN	2.28e-06	2	53	2	25859011
Pubmed	Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.	DMD UTRN	2.28e-06	2	53	2	15703201
Pubmed	Microtubule binding distinguishes dystrophin from utrophin.	DMD UTRN	2.28e-06	2	53	2	24706788
Pubmed	Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle.	DMD UTRN	2.28e-06	2	53	2	25941878
Pubmed	Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link.	DMD UTRN	2.28e-06	2	53	2	9297964
Pubmed	Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice.	DMD UTRN	2.28e-06	2	53	2	10204788
Pubmed	SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.	DMD UTRN	2.28e-06	2	53	2	25652448
Pubmed	Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.	DMD UTRN	2.28e-06	2	53	2	28785010
Pubmed	The role of proteases in excitation-contraction coupling failure in muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	25298424
Pubmed	Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.	DMD UTRN	2.28e-06	2	53	2	16307000
Pubmed	Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice.	DMD UTRN	2.28e-06	2	53	2	21949353
Pubmed	Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.	DMD UTRN	2.28e-06	2	53	2	23097179
Pubmed	rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.	DMD UTRN	2.28e-06	2	53	2	16819550
Pubmed	The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCs) in the choroid plexus and microvasculature of the brain.	DMD UTRN	2.28e-06	2	53	2	15501597
Pubmed	Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.	DMD UTRN	2.28e-06	2	53	2	11257121
Pubmed	Characterization of dystrophin and utrophin diversity in the mouse.	DMD UTRN	2.28e-06	2	53	2	10072426
Pubmed	The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin.	DMD UTRN	2.28e-06	2	53	2	9625743
Pubmed	Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene.	PDS5B ERBB2	2.28e-06	2	53	2	26334628
Pubmed	Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice.	DMD UTRN	2.28e-06	2	53	2	18973234
Pubmed	Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy.	DMD UTRN	2.28e-06	2	53	2	12387876
Pubmed	Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles.	DMD UTRN	2.28e-06	2	53	2	27881412
Pubmed	Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.	DMD UTRN	2.28e-06	2	53	2	20625423
Pubmed	Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle.	DMD UTRN	2.28e-06	2	53	2	29065908
Pubmed	Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy.	DMD UTRN	2.28e-06	2	53	2	31039133
Pubmed	Developmentally regulated expression and localization of dystrophin and utrophin in the human fetal brain.	DMD UTRN	2.28e-06	2	53	2	11796130
Pubmed	Dystrophin and dystrophin-related protein in the brains of normal and mdx mice.	DMD UTRN	2.28e-06	2	53	2	8159184
Pubmed	Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.	DMD UTRN	2.28e-06	2	53	2	10679963
Pubmed	TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice.	DMD UTRN	2.28e-06	2	53	2	21565990
Pubmed	Generation and characterization of transgenic mice with the full-length human DMD gene.	DMD UTRN	2.28e-06	2	53	2	18083704
Pubmed	Expression of the dystrophin-related protein (utrophin) gene during mouse embryogenesis.	DMD UTRN	2.28e-06	2	53	2	8130373
Pubmed	Early Inflammation in Muscular Dystrophy Differs between Limb and Respiratory Muscles and Increases with Dystrophic Severity.	DMD UTRN	2.28e-06	2	53	2	33497702
Pubmed	Dystrophin and dystrophin-related protein (utrophin) distribution in normal and dystrophin-deficient skeletal muscles.	DMD UTRN	2.28e-06	2	53	2	8186702
Pubmed	ANG1 treatment reduces muscle pathology and prevents a decline in perfusion in DMD mice.	DMD UTRN	2.28e-06	2	53	2	28334037
Interaction	LYN interactions	ERBB2 ARHGEF28 FCGR2A EPHA2 SPTAN1 DMD PLEKHH2 UTRN ADCY9 TULP3	1.08e-05	720	51	10	int:LYN
Interaction	C11orf52 interactions	ERBB2 ITCH EPHA2 SPTAN1 UTRN ADCY9 TULP3	1.26e-05	311	51	7	int:C11orf52
Interaction	NOS1 interactions	DMD UTRN HSPA4 ADCY9	2.48e-05	67	51	4	int:NOS1
Interaction	RHOB interactions	PDS5B ERBB2 TRMT10C ITCH SEMA6D EPHA2 SPTAN1 UTRN ADCY9 TULP3	4.05e-05	840	51	10	int:RHOB
Interaction	CBL interactions	ERBB2 ITCH FCGR2A EPHA2 SPTAN1 HSPA2 HSPA4 TULP3	4.23e-05	516	51	8	int:CBL
Interaction	DNAJC5 interactions	ITCH EPHA2 SPTAN1 ECE1 HSPA2 HSPA4 ADCY9	4.40e-05	378	51	7	int:DNAJC5
Interaction	DNAJC5B interactions	EPHA2 HSPA2 HSPA4 ADCY9	5.77e-05	83	51	4	int:DNAJC5B
Interaction	CEP57 interactions	TRMT10C SPTAN1 RASSF10 CEP152 HSPA2	6.00e-05	165	51	5	int:CEP57
Interaction	MAS1 interactions	PDS5B ERBB2 EPHA2 TUBGCP4	6.63e-05	86	51	4	int:MAS1
Interaction	TNS3 interactions	ERBB2 MAP3K20 DMD UTRN	6.93e-05	87	51	4	int:TNS3
Interaction	RHOD interactions	ERBB2 TRMT10C ITCH SEMA6D EPHA2 SPTAN1 UTRN ADCY9	8.71e-05	572	51	8	int:RHOD
Interaction	GJA1 interactions	DPEP1 ERBB2 ITCH EPHA2 SPTAN1 UTRN ADCY9 TULP3	9.94e-05	583	51	8	int:GJA1
Interaction	FGFR3 interactions	ERBB2 TRMT10C IARS1 EPHA2 UTRN HSPA4	1.39e-04	315	51	6	int:FGFR3
Interaction	TNS1 interactions	ERBB2 DMD UTRN	1.52e-04	41	51	3	int:TNS1
Interaction	RHOJ interactions	ERBB2 TRMT10C ITCH EPHA2 SPTAN1 UTRN ADCY9 TULP3	1.75e-04	633	51	8	int:RHOJ
Interaction	HPSE interactions	ERBB2 HSPA2 HSPA4	1.75e-04	43	51	3	int:HPSE
GeneFamily	EF-hand domain containing\|Plakins	EVPLL EVPL	7.92e-05	8	31	2	939
GeneFamily	Heat shock 70kDa proteins	HSPA2 HSPA4	3.81e-04	17	31	2	583
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DMD UTRN	4.28e-04	18	31	2	91
Coexpression	GSE4984_GALECTIN1_VS_LPS_STIM_DC_DN	SART3 DPEP1 EVPL HSPA4 TULP3	2.14e-05	169	52	5	M6504
Coexpression	DELYS_THYROID_CANCER_UP	FCGR2A EPHA2 EVPL DMD ECE1 MBOAT2 MED13	2.68e-05	445	52	7	M3645
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	PDS5B ITCH KDM5A PRIM2 SPART DMD MBOAT2 MED13 ADCY9	4.23e-05	856	52	9	M4500
Coexpression	GSE2585_THYMIC_MACROPHAGE_VS_MTEC_DN	SEMA6D PRIM2 EVPL CEP152 TUBGCP4	4.56e-05	198	52	5	M6280
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ARHGEF28 KDM5A EML4 UTRN HSPA4 MED13	1.09e-07	192	53	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	ARHGEF28 KDM5A EML4 UTRN HSPA4 MED13	1.12e-07	193	53	6	e6a688bc834f845ff64dae1be64f073eec5091a1
Drug	Riboflavine [83-88-5]; Up 200; 10.6uM; PC3; HT_HG-U133A	SPTAN1 MIOS CEP152 DMD ECE1 ZNF44	5.37e-06	199	51	6	4485_UP
Drug	IDETA	DMD UTRN	2.94e-05	4	51	2	CID003036201
Drug	plakin	SPTAN1 EVPL DMD UTRN	3.43e-05	82	51	4	CID000018752
Drug	Chrysin [480-40-0]; Down 200; 15.8uM; MCF7; HT_HG-U133A	PDS5B SPART HSPA2 ATP8B2 ADCY9	7.11e-05	193	51	5	6485_DN
Drug	Chloramphenicol [56-75-7]; Up 200; 12.4uM; HL60; HT_HG-U133A	SPATA2L ITCH CEP152 UTRN ATP8B2	7.47e-05	195	51	5	1837_UP
Drug	Acacetin [480-44-4]; Down 200; 14uM; MCF7; HT_HG-U133A	ERBB2 ECE1 UTRN HSPA2 ADCY9	7.47e-05	195	51	5	3942_DN
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A	SPTAN1 EVPL ECE1 MBOAT2 TULP3	7.65e-05	196	51	5	4955_DN
Drug	Cholecalciferol [67-97-0]; Down 200; 10.4uM; MCF7; HT_HG-U133A	SPATA2L MAP3K20 ECE1 ATP8B2 TULP3	7.65e-05	196	51	5	3298_DN
Drug	Clemizole hydrochloride [1163-36-6]; Down 200; 11uM; HL60; HT_HG-U133A	SPATA2L MAP3K20 CEP152 ECE1 ATP8B2	7.65e-05	196	51	5	2339_DN
Drug	Calycanthine [595-05-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A	EPHA2 EVPL CEP152 MBOAT2 ADCY9	7.65e-05	196	51	5	2764_DN
Drug	Desipramine hydrochloride [58-28-6]; Down 200; 13.2uM; MCF7; HT_HG-U133A	MAP3K20 EVPL CEP152 ADCY9 ZNF44	7.84e-05	197	51	5	5292_DN
Drug	Minoxidil [38304-91-5]; Down 200; 19.2uM; MCF7; HT_HG-U133A	PDS5B EPHA2 UTRN ADCY9 TULP3	7.84e-05	197	51	5	1496_DN
Drug	Pentolinium bitartrate [52-62-0]; Down 200; 7.4uM; HL60; HT_HG-U133A	ITCH EML4 SPTAN1 ECE1 UTRN	7.84e-05	197	51	5	2343_DN
Drug	Hydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HG-U133A	ERBB2 KDM5A EVPL TULP3 KLHL26	7.84e-05	197	51	5	1941_DN
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; HL60; HT_HG-U133A	SPTAN1 MAP3K20 ECE1 HSPA2 ZNF44	8.03e-05	198	51	5	2555_DN
Drug	Niridazole [61-57-4]; Down 200; 18.6uM; PC3; HT_HG-U133A	PDS5B SPTAN1 ECE1 UTRN ZNF44	8.03e-05	198	51	5	4621_DN
Drug	Cefixime [79350-37-1]; Down 200; 8.8uM; PC3; HT_HG-U133A	PDS5B KDM5A MAP3K20 UTRN HSPA2	8.03e-05	198	51	5	4567_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; HL60; HT_HG-U133A	SPATA2L SPTAN1 UTRN ATP8B2 ZNF44	8.03e-05	198	51	5	2352_DN
Drug	Glibenclamide [10238-21-8]; Down 200; 8uM; PC3; HT_HG-U133A	SPATA2L ARHGEF28 EVPL CEP152 KLHL26	8.03e-05	198	51	5	5849_DN
Drug	17-aminogeldanamycin	ERBB2 HSPA4	1.03e-04	7	51	2	CID000429444
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	EML4 DMD UTRN	3.75e-05	36	53	3	DOID:11723 (implicated_via_orthology)
Disease	dilated cardiomyopathy (is_marker_for)	ERBB2 DMD ECE1	4.78e-05	39	53	3	DOID:12930 (is_marker_for)
Disease	muscular dystrophy (implicated_via_orthology)	DMD UTRN	6.50e-04	21	53	2	DOID:9884 (implicated_via_orthology)
Disease	stomach carcinoma (is_marker_for)	ERBB2 KDM5A	8.52e-04	24	53	2	DOID:5517 (is_marker_for)
Disease	blood manganese measurement	ADCY9 KLHL26	1.08e-03	27	53	2	EFO_0007581
Disease	cardiovascular disease	DPEP1 EPHA2 RASSF10 HSPA4 ADCY9	1.36e-03	457	53	5	EFO_0000319

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLGSQDLLNWCMQIA	ERBB2	816	P04626
LQTCLDQSRREWTMQ	CEP152	1016	O94986
YQMAQLLRDRDWINQ	ACCS	361	Q96QU6
LWQRNQEDLLREMIS	DPH6	141	Q7L8W6
QRQLNLMKWTLCHRQ	GVINP1	156	Q7Z2Y8
QMSQNVCPRNLWLLQ	FCGR2A	6	P12318
QEQMNLLNSRWECLR	DMD	421	P11532
QNMLLRGCVLRNTEW	ATP8B2	246	P98198
LSAEIQEELNQRWMR	RASSF10	346	A6NK89
ALNEMWKCQNLLRHQ	PDS5B	491	Q9NTI5
RNNWMRRIQQAVESC	ARHGEF28	1176	Q8N1W1
KWQRDMCNVLLQLED	PNLIPRP3	101	Q17RR3
IENQLLWQIDREMLN	HSPA4	581	P34932
RWDLISNLRIQQIEM	MBOAT2	316	Q6ZWT7
NNNVTEELCRRWMQL	MGAM2	611	Q2M2H8
QLCQLQRRMHTLWQE	CCDC178	796	Q5BJE1
KCQEVINWLDRNQMA	HSPA2	576	P54652
QRRILQQDWSDLMAD	EVPLL	201	A8MZ36
QRRILQQDWSDLMAD	EVPL	246	Q92817
RRVQAELQHCWALQM	TUBGCP4	486	Q9UGJ1
LQCLTERAMSWQDRA	KDM5A	1246	P29375
EQLRQLCQRLSTRWM	PLEKHH2	1311	Q8IVE3
SLWQRQRLQSECKMA	OPN4	281	Q9UHM6
CQSEELRRWFIQQEM	PRIM2	111	P49643
LLCGMQEIDLNDWQR	ITCH	781	Q96J02
MSDINLDWVDRRQLQ	IDI2	1	Q9BXS1
QDLWDLRQRLMNVQF	HYLS1	126	Q96M11
NRWLRLQAMQESRIQ	KLHL26	391	Q53HC5
LDRRRWLMAQQQQEL	CCDC200	16	A0A1B0GVQ3
IYQLMMQCWQQERAR	EPHA2	846	P29317
IQSMRDQADWLLRNI	ADCY9	1021	O60503
CQWLDTLRMRQIASN	MAP3K20	571	Q9NYL2
AQDRQVCLWNSMEHR	EML4	611	Q9HC35
DRCLLNNYMIWNLVR	ECE1	386	P42892
WQLLDMFNNRLQDER	DPEP1	41	P16444
QNWARIEARLCNNMQ	SART3	476	Q15020
QEQMTLLNARWEALR	UTRN	391	P46939
AQRRLWLQRAQMDTL	SPATA2L	401	Q8IUW3
RWAEDQNSLRKMICQ	RGPD2	801	P0DJD1
DQWGELQLLCMQLDR	FAM178B	616	Q8IXR5
LRQENQMWNREGCRC	HEXIM2	266	Q96MH2
NMVDQLLRNNDLCYW	IARS1	421	P41252
VDRVWQECNMNRAQN	MED13	376	Q9UHV7
LLRQMSDLRLQANWN	SPART	326	Q8N0X7
LWREMCSTLRLQLNN	MIOS	571	Q9NXC5
SLWEKACENLRNLNM	TRIM51	146	Q9BSJ1
WELRRQQYEQCMDLQ	SPTAN1	456	Q13813
ESLLAQREWQSNMQR	YAE1	26	Q9NRH1
RNLNMATNRIRCWKD	TRIM51G	156	A0A3B3IT33
LTWRSRQQDRENCAM	SEMA6D	96	Q8NFY4
MIRILLCLKNNGNWQ	TRMT10C	356	Q7L0Y3
LLSRWQNRTMENLVE	TULP3	346	O75386
RNLNCIGMKWENQNI	ZNF44	86	P15621