Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Aplasia/Hypoplasia involving bones of the skull	BUD23 RAD51C PTPN11 ZBTB20 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	1.21e-05	915	30	16	HP:0009116
HumanPheno	Micrognathia	BUD23 RAD51C PTPN11 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	2.24e-05	843	30	15	HP:0000347
HumanPheno	Aplasia/Hypoplasia of the mandible	BUD23 RAD51C PTPN11 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	2.31e-05	845	30	15	HP:0009118
HumanPheno	Narrow face	BUD23 ATR UBE3B MYPN HECTD4 NEB	3.10e-05	108	30	6	HP:0000275
HumanPheno	Aplasia/hypoplasia affecting bones of the axial skeleton	BUD23 RAD51C PTPN11 ZBTB20 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	4.31e-05	1008	30	16	HP:0009122
HumanPheno	Abnormal shoulder morphology	BUD23 CCN6 PTPN11 EBF3 ENPP1 MYPN NEB GDF3	6.12e-05	246	30	8	HP:0003043
HumanPheno	Abnormal palate morphology	RAD51C PTPN11 ZBTB20 SEC24C ATR EBF3 ENPP1 UBE3B MYPN HECTD4 NEB SMC5 GDF3 TRRAP ARCN1 EDNRA MADD	9.56e-05	1202	30	17	HP:0000174
HumanPheno	Abnormal curvature of the vertebral column	BUD23 RAD51C CCN6 TRAPPC11 PTPN11 ZBTB20 SEC24C ATR EBF3 ENPP1 MYPN HECTD4 NEB SMC5 GDF3 TRRAP MADD	1.15e-04	1219	30	17	HP:0010674
HumanPheno	Abnormal breast morphology	RAD51C PMS1 PTPN11 ZBTB20 ATR EBF3 SMC5 TRRAP ARCN1 MADD	1.31e-04	441	30	10	HP:0031093
HumanPheno	Small face	BUD23 ATR UBE3B MYPN HECTD4 NEB	1.44e-04	142	30	6	HP:0000274
HumanPheno	Abnormality of the breast	RAD51C PMS1 PTPN11 ZBTB20 ATR EBF3 SMC5 TRRAP ARCN1 MADD	1.47e-04	447	30	10	HP:0000769
HumanPheno	Abnormal mandible morphology	BUD23 RAD51C PTPN11 ZBTB20 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	1.61e-04	1118	30	16	HP:0000277
HumanPheno	Calcification of the auricular cartilage	ZBTB20 ENPP1	2.00e-04	4	30	2	HP:0005103
HumanPheno	Periarticular calcification	CCN6 ENPP1	2.00e-04	4	30	2	HP:0025477
HumanPheno	Abnormality of the jaws	BUD23 RAD51C PTPN11 ZBTB20 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	2.99e-04	1175	30	16	HP:0000209
HumanPheno	Abnormal jaw morphology	BUD23 RAD51C PTPN11 ZBTB20 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	3.02e-04	1176	30	16	HP:0030791
HumanPheno	Abnormal synovial membrane morphology	RAD51C CCN6 TRAPPC11 PTPN11 ZBTB20 ATR EBF3 ENPP1 UBE3B NEB	3.90e-04	503	30	10	HP:0005262
HumanPheno	Spina bifida	BUD23 RAD51C PTPN11 SEC24C EBF3 GDF3	3.98e-04	171	30	6	HP:0002414
HumanPheno	Aplasia/hypoplasia involving the skeleton	BUD23 RAD51C CCN6 PTPN11 ZBTB20 SEC24C ATR EBF3 UBE3B MYPN HECTD4 NEB SMC5 TRRAP ARCN1 EDNRA MADD	4.12e-04	1343	30	17	HP:0009115
MousePheno	incudomalleolar fusion	ENPP1 EDNRA	6.57e-05	3	66	2	MP:0030110
MousePheno	calcified retina	ENPP1 UBE3B	6.57e-05	3	66	2	MP:0006188
MousePheno	calcified intraocular region	ENPP1 UBE3B	6.57e-05	3	66	2	MP:0006209
MousePheno	small olfactory bulb	EBF2 EBF3 HYDIN TOP2B	1.12e-04	53	66	4	MP:0002741
Domain	-	PDC PDCL	1.95e-05	2	83	2	1.10.168.10
Domain	Phosducin_N_dom	PDC PDCL	1.95e-05	2	83	2	IPR023196
Domain	ZINC_FINGER_C2H2_2	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF804B HELZ2 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	3.53e-05	775	83	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF804B HELZ2 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	3.62e-05	777	83	13	PS00028
Domain	Znf_C2H2-like	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF804B HELZ2 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	4.65e-05	796	83	13	IPR015880
Domain	ZnF_C2H2	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF804B HELZ2 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	5.42e-05	808	83	13	SM00355
Domain	Transcription_factor_COE	EBF2 EBF3	1.16e-04	4	83	2	IPR003523
Domain	Phosducin	PDC PDCL	1.16e-04	4	83	2	IPR001200
Domain	COE_HLH	EBF2 EBF3	1.16e-04	4	83	2	IPR032201
Domain	COE_DBD	EBF2 EBF3	1.16e-04	4	83	2	IPR032200
Domain	Transcription_factor_COE_CS	EBF2 EBF3	1.16e-04	4	83	2	IPR018350
Domain	COE1_HLH	EBF2 EBF3	1.16e-04	4	83	2	PF16423
Domain	COE1_DBD	EBF2 EBF3	1.16e-04	4	83	2	PF16422
Domain	Phosducin	PDC PDCL	1.16e-04	4	83	2	PF02114
Domain	COE	EBF2 EBF3	1.16e-04	4	83	2	PS01345
Domain	Phosducin_thioredoxin-like_dom	PDC PDCL	1.16e-04	4	83	2	IPR024253
Domain	Znf_C2H2	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF804B ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	2.20e-04	805	83	12	IPR007087
Domain	zf-C2H2	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	2.41e-04	693	83	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681 ZNF687	2.44e-04	694	83	11	IPR013087
Domain	FAT	ATR TRRAP	2.89e-04	6	83	2	PS51189
Domain	FATC	ATR TRRAP	2.89e-04	6	83	2	PS51190
Domain	FAT	ATR TRRAP	2.89e-04	6	83	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR TRRAP	2.89e-04	6	83	2	IPR003151
Domain	FATC_dom	ATR TRRAP	2.89e-04	6	83	2	IPR003152
Domain	PIK_FAT	ATR TRRAP	2.89e-04	6	83	2	IPR014009
Domain	FATC	ATR TRRAP	2.89e-04	6	83	2	SM01343
Domain	zf-C2H2_6	ZSCAN31 ZNF273 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681	4.94e-04	314	83	7	PF13912
Domain	-	HYDIN MOSPD1	5.37e-04	8	83	2	2.60.40.360
Domain	PapD-like	HYDIN MOSPD1	6.88e-04	9	83	2	IPR008962
Domain	-	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681	8.39e-04	679	83	10	3.30.160.60
Domain	TUDOR	TDRD7 TDRD15	1.72e-03	14	83	2	PF00567
Domain	-	ATR TRRAP	2.25e-03	16	83	2	1.10.1070.11
Domain	PI3Kc	ATR TRRAP	2.25e-03	16	83	2	SM00146
Domain	HEAT_type_2	ATR KPNB1	2.54e-03	17	83	2	IPR021133
Domain	PI3/4_kinase_cat_dom	ATR TRRAP	2.85e-03	18	83	2	IPR000403
Domain	PI3_PI4_kinase	ATR TRRAP	2.85e-03	18	83	2	PF00454
Domain	PI3_4_KINASE_3	ATR TRRAP	2.85e-03	18	83	2	PS50290
Domain	PI3_4_KINASE_1	ATR TRRAP	2.85e-03	18	83	2	PS00915
Domain	PI3_4_KINASE_2	ATR TRRAP	2.85e-03	18	83	2	PS00916
Domain	HATPase_c	PMS1 TOP2B	2.85e-03	18	83	2	SM00387
Domain	HATPase_c	PMS1 TOP2B	3.18e-03	19	83	2	PF02518
Domain	Synaptotagmin	SYT11 SYT9	3.52e-03	20	83	2	IPR001565
Domain	-	PMS1 TOP2B	3.52e-03	20	83	2	3.30.565.10
Domain	-	PMS1 TOP2B	3.88e-03	21	83	2	3.30.230.10
Domain	HATPase_C	PMS1 TOP2B	3.88e-03	21	83	2	IPR003594
Domain	Ribosomal_S5_D2-typ_fold_subgr	PMS1 TOP2B	4.25e-03	22	83	2	IPR014721
Domain	TUDOR	TDRD7 TDRD15	4.65e-03	23	83	2	PS50304
Domain	KRAB	ZNF33A ZNF273 ZNF763 ZNF416 ZNF682 ZNF681	5.20e-03	358	83	6	PS50805
Domain	KRAB	ZNF33A ZNF273 ZNF763 ZNF416 ZNF682 ZNF681	5.20e-03	358	83	6	PF01352
Domain	KRAB	ZNF33A ZNF273 ZNF763 ZNF416 ZNF682 ZNF681	6.01e-03	369	83	6	SM00349
Domain	KRAB	ZNF33A ZNF273 ZNF763 ZNF416 ZNF682 ZNF681	6.09e-03	370	83	6	IPR001909
Domain	TUDOR	TDRD7 TDRD15	6.37e-03	27	83	2	SM00333
Domain	IPT	EBF2 EBF3	6.37e-03	27	83	2	SM00429
Domain	Tudor	TDRD7 TDRD15	7.83e-03	30	83	2	IPR002999
Domain	TIG	EBF2 EBF3	8.35e-03	31	83	2	PF01833
Pubmed	The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.	EBF2 EBF3	1.94e-05	3	89	2	9151732
Pubmed	BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells.	PTPN11 PEAK1	1.94e-05	3	89	2	34273398
Pubmed	Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.	PDC PDCL	1.94e-05	3	89	2	10884381
Pubmed	Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.	EBF2 EBF3	3.87e-05	4	89	2	9151733
Pubmed	Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.	CD84 PTPN11	3.87e-05	4	89	2	11414741
Pubmed	Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.	IFIT5 IFIT3	3.87e-05	4	89	2	34763233
Pubmed	Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.	MYPN NEB	3.87e-05	4	89	2	12482578
Pubmed	Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection.	EBF2 EBF3	3.87e-05	4	89	2	12139918
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF107 ZNF682 ZNF681	5.64e-05	29	89	3	14563677
Pubmed	ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis.	EBF2 ADAM7	6.44e-05	5	89	2	9322939
Pubmed	Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.	EBF2 EBF3	6.44e-05	5	89	2	12917357
Pubmed	Diversity of group types, regulation, and function of phospholipase A2.	PLA2G1B PLA2G2C	6.44e-05	5	89	2	8175726
Pubmed	Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.	CD84 PTPN11	6.44e-05	5	89	2	11389028
Pubmed	Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.	ATR MDM4	6.44e-05	5	89	2	22556425
Pubmed	Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development.	EBF2 EBF3	6.44e-05	5	89	2	15261831
Pubmed	Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.	CD84 PTPN11	9.65e-05	6	89	2	11477068
Pubmed	LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms.	RAD51C ATR	9.65e-05	6	89	2	35849344
Pubmed	The broad-spectrum antiviral functions of IFIT and IFITM proteins.	IFIT5 IFIT3	9.65e-05	6	89	2	23237964
Pubmed	Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.	CD84 PTPN11	9.65e-05	6	89	2	11689425
Pubmed	Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.	EBF2 EBF3	9.65e-05	6	89	2	9389446
Pubmed	HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells.	CCL7 IFIT3 KPNB1	1.18e-04	37	89	3	24742347
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	EBF2 EBF3	1.35e-04	7	89	2	24786561
Pubmed	DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase.	PTPN11 ATR	1.35e-04	7	89	2	12937170
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	MEIOC PHF23 CAGE1 MDM4 IFIT3	1.64e-04	199	89	5	31146259
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KANSL2 SEC24C ATR SSH1 AAK1 HELZ2 TRRAP TOP2B ZNF687	1.66e-04	774	89	9	15302935
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	ZNF33A SEC24C SYT11	1.73e-04	42	89	3	7584044
Pubmed	On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes.	PLA2G1B PLA2G2C	1.79e-04	8	89	2	10531313
Pubmed	Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.	MYPN NEB	1.79e-04	8	89	2	11309420
Pubmed	Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection.	EBF2 EBF3	1.79e-04	8	89	2	14993187
Pubmed	Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2.	EBF2 ADAM7	1.79e-04	8	89	2	17268172
Pubmed	Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X.	SYT11 SYT9	2.30e-04	9	89	2	10531343
Pubmed	Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.	CCNG1 IFIT3	2.30e-04	9	89	2	30380406
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF107 ZNF682 ZNF681	2.74e-04	49	89	3	9630514
Pubmed	The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners.	TRRAP KPNB1	2.88e-04	10	89	2	15870280
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	ATR TRRAP	2.88e-04	10	89	2	18160036
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	TDRD7 ATP13A5 CCDC168 PDCL	2.88e-04	123	89	4	26912792
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATR TRRAP	3.51e-04	11	89	2	20427287
Pubmed	SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.	SYT11 SYT9	3.51e-04	11	89	2	10734137
Pubmed	Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.	EBF2 EBF3	3.51e-04	11	89	2	10704382
Pubmed	Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition.	EBF2 ZBTB20 EBF3	4.07e-04	56	89	3	34170322
Pubmed	HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.	RAD51C ATR	4.20e-04	12	89	2	24005329
Pubmed	Transient and lineage-restricted requirement of Ebf3 for sternum ossification.	EBF2 EBF3	4.20e-04	12	89	2	32398354
Pubmed	An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.	EBF2 EBF3	4.20e-04	12	89	2	30658714
Pubmed	Control of the migratory pathway of facial branchiomotor neurones.	EBF2 EBF3	4.96e-04	13	89	2	11076752
Pubmed	Progenitor cell diversity in the developing mouse neocortex.	EBF2 ZBTB20	4.96e-04	13	89	2	33649223
Pubmed	Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.	RAD51C ATR	4.96e-04	13	89	2	19064565
Pubmed	Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem.	EBF2 EBF3	4.96e-04	13	89	2	22421355
Pubmed	Genomic analysis of synaptotagmin genes.	SYT11 SYT9	4.96e-04	13	89	2	11543631
Pubmed	Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.	PTPN11 UBE3B ALAS1	5.76e-04	63	89	3	17672918
Pubmed	Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development.	PLA2G1B PLA2G2C	5.78e-04	14	89	2	12050136
Pubmed	Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine.	CCL7 IFIT3	5.78e-04	14	89	2	7622488
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF107 ZNF681	6.65e-04	15	89	2	15885501
Pubmed	Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.	PMS1 KPNB1	6.65e-04	15	89	2	20603015
Pubmed	Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse.	EBF2 EBF3	6.65e-04	15	89	2	25762221
Pubmed	Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.	RAD51C PMS1 ATR	7.20e-04	68	89	3	20496165
Pubmed	Control of neuronal morphology by the atypical cadherin Fat3.	EBF2 EBF3	7.59e-04	16	89	2	21903076
Pubmed	Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.	CCNG1 MDM4	7.59e-04	16	89	2	35593225
Pubmed	Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.	PTPN11 HECTD4	7.59e-04	16	89	2	21572416
Pubmed	Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.	MYPN NEB	7.59e-04	16	89	2	25987543
Pubmed	Identification of casein kinase Ialpha interacting protein partners.	SYT9 KPNB1	8.59e-04	17	89	2	12062430
Pubmed	The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells.	EBF2 EBF3	8.59e-04	17	89	2	27889898
Pubmed	HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.	PLA2G1B PLA2G2C	1.08e-03	19	89	2	9377118
Pubmed	Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.	MYPN NEB	1.08e-03	19	89	2	27171814
Pubmed	Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.	PTPN11 ZNF687 AZIN1 IHO1	1.11e-03	176	89	4	27229929
Pubmed	Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair.	IFIT3 CA8	1.19e-03	20	89	2	34655526
Pubmed	A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography.	EBF2 EBF3	1.19e-03	20	89	2	16774995
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF33A ZNF273 ZNF107 ZNF681	1.23e-03	181	89	4	37372979
Pubmed	Mdm4 controls ureteric bud branching via regulation of p53 activity.	CCNG1 MDM4	1.32e-03	21	89	2	32464196
Pubmed	The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.	EBF2 EBF3	1.32e-03	21	89	2	27600842
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	PMS1 ATR KPNB1	1.47e-03	87	89	3	17148452
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	DDX47 PTPN11 SEC24C ENPP1 TOP2B KPNB1	1.55e-03	484	89	6	31995728
Pubmed	MCM9 Is Required for Mammalian DNA Mismatch Repair.	DDX47 PMS1	1.58e-03	23	89	2	26300262
Pubmed	Proteomic data on the nuclear interactome of human MCM9.	DDX47 PMS1	1.58e-03	23	89	2	26870752
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	ATR KPNB1	1.72e-03	24	89	2	21466675
Pubmed	Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors.	EBF2 EBF3	1.72e-03	24	89	2	20826655
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DDX47 NEB SMC5 TRRAP HYDIN ZNF687	1.77e-03	497	89	6	36774506
Pubmed	A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response.	AGTR2 EDNRA	1.87e-03	25	89	2	12544508
Pubmed	Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.	EBF2 EBF3	1.87e-03	25	89	2	15229182
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	PLA2G1B PLA2G2C	2.02e-03	26	89	2	9745929
Pubmed	Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.	EBF2 EBF3	2.18e-03	27	89	2	33760820
Pubmed	A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.	CCNG1 MDM4	2.18e-03	27	89	2	34242585
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	PMS1 PTPN11 SEC24C ZNF687 KPNB1	2.27e-03	357	89	5	37059091
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	PTPN11 SEC24C AAK1 IFIT5 PEAK1 ARCN1 KPNB1	2.29e-03	708	89	7	39231216
Pubmed	The protein kinase complement of the human genome.	AAK1 PEAK1	2.34e-03	28	89	2	12471243
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	ZBTB20 EBF3	2.34e-03	28	89	2	17614941
Pubmed	EBF2 determines and maintains brown adipocyte identity.	EBF2 EBF3	2.51e-03	29	89	2	23499423
Pubmed	Multimodal Hox5 activity generates motor neuron diversity.	EBF2 EBF3	2.51e-03	29	89	2	39289460
Cytoband	12p13.1	DDX47 GDF3	7.62e-04	21	89	2	12p13.1
Cytoband	8p21.2	EBF2 ADAM7	1.08e-03	25	89	2	8p21.2
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	PTPN11 SSH1 UBE3B HECTD4 PLA2G1B	1.31e-03	415	89	5	chr12q24
Cytoband	12q24.11	SSH1 UBE3B	1.89e-03	33	89	2	12q24.11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB20 ZNF33A ZSCAN31 ZNF273 ZNF319 ZNF763 ZNF107 ZNF416 ZNF682 ZNF681	5.31e-05	718	55	10	28
GeneFamily	Synaptotagmins	SYT11 SYT9	1.20e-03	17	55	2	765
GeneFamily	Tudor domain containing	TDRD7 TDRD15	5.65e-03	37	55	2	780
GeneFamily	Kelch like\|BTB domain containing	KLHL5 IPP	7.24e-03	42	55	2	617
GeneFamily	Phospholipases	PLA2G1B PLA2G2C	7.24e-03	42	55	2	467
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL5 ZBTB20 IPP	7.89e-03	134	55	3	861
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	STPG1 SCNN1B ZNF107 ZNF682 TOP2B ZNF681	5.75e-07	150	89	6	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	Mild\|World / Disease group and Cell class	ZBTB20 AAK1 HELZ2 IFIT5 ZNF107 IFIT3	2.72e-06	196	89	6	5e4ed4a5a437cfa002b92775992a791e27aa4c27
Disease	Nemaline Myopathy, Childhood Onset	MYPN NEB	1.75e-04	7	86	2	C0546125
Disease	Influenza	TDRD7 IFIT5 IFIT3	4.76e-04	52	86	3	C0021400
Disease	Antithrombotic agent use measurement	TDRD15 HECTD4 EDNRA	5.62e-04	55	86	3	EFO_0009925
Disease	ovarian neoplasm	RAD51C PMS1 ATR EDNRA	6.47e-04	134	86	4	C0919267
Disease	creatine kinase measurement	CEP112 MYPN NEB	6.91e-04	59	86	3	EFO_0004534
Disease	Malignant neoplasm of ovary	RAD51C PMS1 ATR EDNRA	7.03e-04	137	86	4	C1140680
Disease	Pneumoconiosis	ATR MDM4	7.47e-04	14	86	2	C0032273
Disease	Bagassosis	ATR MDM4	7.47e-04	14	86	2	C0004681
Disease	Antihypertensive use measurement	EBF2 RERGL UBE3B EDNRA MADD	1.08e-03	265	86	5	EFO_0009927
Disease	glomerulonephritis (implicated_via_orthology)	AGTR2 CCL7	1.11e-03	17	86	2	DOID:2921 (implicated_via_orthology)
Disease	Malignant neoplasm of endometrium	PMS1 ATR	1.25e-03	18	86	2	C0007103
Disease	Carcinoma of bladder	PEAK1 MDM4	1.25e-03	18	86	2	C0699885
Disease	Carcinoma in situ of endometrium	PMS1 ATR	1.25e-03	18	86	2	C0346191
Disease	lipid measurement, lipoprotein measurement	TDRD15 PTPN11 KPNB1	2.34e-03	90	86	3	EFO_0004529, EFO_0004732

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKCTLNPIFNESFIY	SYT11	351	Q9BT88
KNPVKCAVSSKYQTV	DDX47	221	Q9H0S4
YQVFKAVKLCPSETS	DCANP1	156	Q8TF63
ANKKSENPAKRLYCF	BUD23	131	O43709
FCLYLSTLKFPVSKK	ATP13A5	91	Q4VNC0
FLCKTAVPSKEIQNY	CAGE1	226	Q8TC20
QVSYFSFKLLKKECP	AAK1	306	Q2M2I8
ISPCKQVSQIKYAAK	AZIN1	111	O14977
PQKNATVKCKTIFLY	ADAM7	581	Q9H2U9
CQKGPKKVSSIYIFN	AGTR2	71	P50052
QNITPKICEVYSKKS	CEP112	181	Q8N8E3
VTLSYKSKQFCKGAP	EBF2	316	Q9HAK2
NSCINPIALYFVSKK	EDNRA	361	P25101
LYKSPSQKECTVLFQ	RAD51C	326	O43502
PKENKFCSFLQTSKV	IPP	266	Q9Y573
CFKESLPTYEKNFKQ	PLA2G2C	121	Q5R387
EYSSNKCSKPNVQKL	CCNG1	251	P51959
NGSETQLNKFYTKKC	MADD	1501	Q8WXG6
AYIKKENSKLFDPCN	MDM4	376	O15151
KAGKSLLFYAQNCPK	ALAS1	21	P13196
QKQIPIQTCKFNSKY	IHO1	461	Q8IYA8
FFLYPKKISQASSCL	GDF3	91	Q9NR23
EYPIVKFCKIKASNT	PDC	161	P20941
DPLNNYAVKICKSKA	PEAK1	1351	Q9H792
KDQPVAFTYCAKTSI	GANC	881	Q8TET4
FALKFKVLCTTPNKY	MOSPD1	46	Q9UJG1
SPVHKCSFYKNNTKV	ENPP1	721	P22413
TKCNNSKPKKSYIAT	PTPN11	316	Q06124
SKPKKSYIATQGCLQ	PTPN11	321	Q06124
LLCPSSAVNKNKGKY	HECTD4	3671	Q9Y4D8
KTLNTVECYNPKTKT	KLHL5	526	Q96PQ7
KTCQPTFQLSKAEKF	CCN6	266	O95389
KLQSFFSQYKKPICQ	ATR	921	Q13535
LNFSTCPVKYSTQKI	HYDIN	206	Q4G0P3
GNVCKKLSSPSNYKL	IFIT5	121	Q13325
CKSKQKSKDFSLYPQ	KLRF2	16	D3W0D1
KDIQFRSQIKYSCPK	CR1L	111	Q2VPA4
YKGKSKTIPCFNPNT	CA8	191	P35219
YVDKVKQTCKKFSNP	IFIT3	116	O14879
VKNSAKDCYPAVQKT	KPNB1	536	Q14974
APFKQCSYISTKNGK	KANSL2	56	Q9H9L4
NAEYIDKSCTFKKPQ	CCDC168	891	Q8NDH2
STTCCYRFINKKIPK	CCL7	31	P80098
VTLSYKSKQFCKGAP	EBF3	326	Q9H4W6
ICAFPSVAFYKSKLK	HELZ2	2431	Q9BYK8
FLATVDYCKNNKFPS	SEC24C	486	P53992
TICNASPFKYSKIKH	SCNN1B	96	P51168
NLPVRKQFYSTAKKC	PMS1	151	P54277
SFVSKKNYCNIQVTK	ARCN1	471	P48444
AAEYPAVKFCKVKSS	PDCL	206	Q13371
SNSKACGKLNFILKY	SYT9	216	Q86SS6
AKTTFQEYPLIKNCF	MEIOC	256	A2RUB1
QFCPKDTQLKYFEKQ	TATDN1	121	Q6P1N9
IYDPCSQTQKAKFSL	RERGL	56	Q9H628
QTQLNKKCSSVKYSK	TOP2B	441	Q02880
KVSSALSPSKFYCQL	TDRD15	246	B5MCY1
SCLNTFTKNPYAASK	CD84	261	Q9UIB8
FPSVQQKKKAFSTCS	OR6C68	226	A6NDL8
ICFSKAPYNKAHKNL	PLA2G1B	126	P04054
SYQSAFTPAKRLKNC	RNF220	131	Q5VTB9
YKLNPKFCSLSFQAT	TDRD7	561	Q8NHU6
KQAKVFSLPSQTCLY	STXBP5L	956	Q9Y2K9
FGILNKVKPSYKSCA	SSH1	636	Q8WYL5
FCEEQKKGSTYSVPK	SPATA33	11	Q96N06
TPSKIFQCNKYVKVF	ZNF107	71	Q9UII5
TTTQSKIFQCDKYVK	ZNF273	171	Q14593
HDCNKSPIYKTKQTA	ZNF804B	246	A4D1E1
EKPYQCSQCSKLFSK	ZSCAN31	376	Q96LW9
LSNAVAQFKKYKCPR	TRAPPC11	436	Q7Z392
YNPSDCTKVPKKTLF	STPG1	231	Q5TH74
PYNKCVKVFSKSSNL	ZNF682	146	O95780
KKPYVSKQCGKSLSN	ZNF705EP	141	A8MWA4
SCAKIKKTNVPDFFY	PHF23	366	Q9BUL5
SSHFCPNVKLKAQTY	SEPTIN10	96	Q9P0V9
KPYECTLCNKTFTAK	ZBTB20	576	Q9HC78
TLCNKTFTAKQNYVK	ZBTB20	581	Q9HC78
KPYECNTCRKTFSQK	ZNF33A	746	Q06730
GYQKCFQKEKTSPAK	TMEM241	111	Q24JQ0
PVCNKAYKRASALQK	ZNF319	431	Q9P2F9
CFNLLKLPNYSKKSV	UBE3B	1036	Q7Z3V4
KQKSPISFFQCVYLD	TRDN	681	Q13061
AIANYEKPNKISKCE	ZNF416	191	Q9BWM5
KLYKPKRCNSDFENT	ZNF681	616	Q96N22
PSFQTQQAKLIYKCA	ZNF687	816	Q8N1G0
FYKAKPIFSCLNTAL	UCN3	26	Q969E3
KQCGKALSYKFSNTP	ZNF763	371	Q0D2J5
ACKENTSQYFFITPK	SMC5	1041	Q8IY18
RYQLSAIFKKCKPQS	TRRAP	461	Q9Y4A5
SLVTAACAKAPYTQK	MYO7B	1371	Q6PIF6
KRPQYCSETQSKKVF	MYPN	136	Q86TC9
AKSINYCETPKFKLD	NEB	396	P20929