Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncadherin binding

GAPVD1 UBAP2 APC JUP FASN PTPRH PKP1 MACF1 GOLGA3

5.59e-053391019GO:0045296
GeneOntologyMolecularFunctionGq/11-coupled serotonin receptor activity

HTR2A HTR2B

7.57e-0531012GO:0001587
GeneOntologyCellularComponentG protein-coupled serotonin receptor complex

HTR2A HTR2B

1.38e-0441012GO:0098666
DomainARM-like

SAAL1 ATR APC XPO1 TEX10 TRRAP JUP CTNNBL1 PKP1 ULK4 PPP6R3

1.93e-072709911IPR011989
DomainARM-type_fold

SAAL1 ATR APC XPO1 TEX10 TRRAP RYR3 JUP CTNNBL1 PKP1 ULK4 PPP6R3

2.37e-073399912IPR016024
Domain-

SAAL1 ATR APC XPO1 TEX10 TRRAP JUP CTNNBL1 PKP1 ULK4

2.85e-0722299101.25.10.10
DomainAquaporin_12

AQP12A AQP12B

2.78e-052992IPR023265
DomainAquaporin_11/12

AQP12A AQP12B

8.32e-053992IPR016697
DomainHEAT

ATR XPO1 TEX10 JUP

2.53e-0458994IPR000357
DomainCH

SYNE1 LRCH3 NAV3 MACF1

3.92e-0465994SM00033
DomainFAT

ATR TRRAP

4.11e-046992PS51189
DomainFATC

ATR TRRAP

4.11e-046992PS51190
DomainFAT

ATR TRRAP

4.11e-046992PF02259
DomainPIK-rel_kinase_FAT

ATR TRRAP

4.11e-046992IPR003151
DomainFATC_dom

ATR TRRAP

4.11e-046992IPR003152
DomainPIK_FAT

ATR TRRAP

4.11e-046992IPR014009
DomainFATC

ATR TRRAP

4.11e-046992SM01343
DomainCH

SYNE1 LRCH3 NAV3 MACF1

5.21e-0470994PF00307
DomainHEAT_REPEAT

ATR XPO1 TEX10 ULK4

5.21e-0470994PS50077
Domain-

SYNE1 LRCH3 NAV3 MACF1

5.50e-04719941.10.418.10
DomainArm

APC JUP PKP1

5.83e-0431993PF00514
DomainCH

SYNE1 LRCH3 NAV3 MACF1

6.11e-0473994PS50021
DomainSpectrin/alpha-actinin

AKAP6 SYNE1 MACF1

6.41e-0432993IPR018159
DomainSPEC

AKAP6 SYNE1 MACF1

6.41e-0432993SM00150
DomainCH-domain

SYNE1 LRCH3 NAV3 MACF1

6.77e-0475994IPR001715
DomainZnf_SWIM

ZSWIM5 ZSWIM6

9.77e-049992IPR007527
DomainZF_SWIM

ZSWIM5 ZSWIM6

9.77e-049992PS50966
Domain5HT_rcpt

HTR2A HTR2B

9.77e-049992IPR002231
DomainARM_REPEAT

APC JUP PKP1

1.24e-0340993PS50176
DomainARM

APC JUP PKP1

1.24e-0340993SM00185
DomainArmadillo

APC JUP PKP1

1.98e-0347993IPR000225
DomainHEAT

ATR TEX10 JUP

2.10e-0348993PF02985
DomainKinase-like_dom

CDC42BPG ATR RIPK2 TRRAP MAP3K3 MET ULK4 MACF1 EIF2AK4

2.34e-03542999IPR011009
DomainMIP

AQP12A AQP12B

2.43e-0314992PS00221
DomainMIP

AQP12A AQP12B

2.43e-0314992PF00230
DomainMIP

AQP12A AQP12B

2.79e-0315992IPR000425
Domain-

AQP12A AQP12B

2.79e-03159921.20.1080.10
DomainAquaporin-like

AQP12A AQP12B

2.79e-0315992IPR023271
Domain-

ATR TRRAP

3.18e-03169921.10.1070.11
DomainPI3Kc

ATR TRRAP

3.18e-0316992SM00146
DomainHEAT_type_2

ATR TEX10

3.59e-0317992IPR021133
DomainPI3/4_kinase_cat_dom

ATR TRRAP

4.03e-0318992IPR000403
DomainPI3_PI4_kinase

ATR TRRAP

4.03e-0318992PF00454
DomainPI3_4_KINASE_3

ATR TRRAP

4.03e-0318992PS50290
DomainPI3_4_KINASE_1

ATR TRRAP

4.03e-0318992PS00915
DomainPI3_4_KINASE_2

ATR TRRAP

4.03e-0318992PS00916
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

FAM193B GAPVD1 RAPGEF6 KIAA0586 APC SPAG5 CEP350 MACF1 GOLGA3 PPP6R3

7.18e-102091031036779422
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GAPVD1 RAPGEF6 HIVEP1 UBAP2 MYCBP2 RIPK2 APC DZIP1 PABIR2 MAP3K3 CEP350 JUP PLEKHA3 MACF1 PPIP5K2 ABTB2

5.23e-098611031636931259
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B FAM193B RAPGEF6 MYCBP2 TMEM94 SHC1 TEP1 TRRAP FAAP100 FASN ZNF335 EHMT1 ULK4 ABTB2 HR

9.26e-0711051031535748872
Pubmed

A human MAP kinase interactome.

HIVEP1 SYNE1 APC MAP3K3 CEP350 JUP ZNF451 NAV3 MACF1 BICRAL

1.92e-064861031020936779
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

GAPVD1 HTR2B HSPH1 RIPK2 XPO1 TEX10 TRRAP RYR3 EIF2AK4 ZNF292

2.34e-064971031036774506
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC13B ZSWIM5 TMEM94 SYNE1 ZSWIM6 EPG5 ZNF451 NAV3 MACF1

3.59e-06407103912693553
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

GAPVD1 UBAP2 HSPH1 SHC1 JUP FASN GOLGA3

3.87e-06216103731519766
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

GAPVD1 RAPGEF6 HIVEP1 MYCBP2 APC SPAG5 JUP FASN GOLGA3

4.45e-06418103934709266
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 UNC13B MYCBP2 SYNE1 HSPH1 APC ZBTB47 DZIP1 RYR3 CEP350 ZNF451 NAV3 MACF1 GOLGA3 ZNF292

5.84e-0612851031535914814
Pubmed

Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors.

HTR2A HTR2B

8.69e-062103224244317
Pubmed

Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line.

HTR2A HTR2B

8.69e-062103216517693
Pubmed

The alpha A-crystallin gene: conserved features of the 5'-flanking regions in human, mouse, and chicken.

HIVEP1 CRYAA

8.69e-06210321779432
Pubmed

Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.

HTR2A HTR2B

8.69e-062103221789169
Pubmed

Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.

AQP12A AQP12B

8.69e-062103236167651
Pubmed

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer.

APC FASN

8.69e-062103235742953
Pubmed

Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin.

MET FASN

8.69e-062103222135723
Pubmed

Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.

RIPK2 APC

8.69e-062103231903123
Pubmed

5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.

HTR2A HTR2B

8.69e-062103223346101
Pubmed

Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA.

RIPK2 MET

8.69e-062103233204717
Pubmed

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog.

HTR2A HTR2B

8.69e-062103215862800
Pubmed

Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.

HTR2A HTR2B

8.69e-062103231787571
Pubmed

Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.

AQP12A AQP12B

8.69e-062103215809071
Pubmed

Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.

SAAL1 PABIR2

8.69e-062103222127701
Pubmed

Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.

AQP12A AQP12B

8.69e-062103219726746
Pubmed

Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor.

SHC1 MET

8.69e-062103227048591
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

UNC13B SAAL1 HIVEP1 UBAP2 MYCBP2 APC TEX10 TRRAP PABIR2 JUP PKP1 EIF2AK4 PPP6R3

8.79e-0610051031319615732
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

RAPGEF6 UBAP2 HSPH1 APC SPAG5 JUP FASN

1.17e-05256103733397691
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

GAPVD1 ATR TMEM94 HSPH1 RIPK2 SHC1 TEX10 TRRAP MAP3K3 MET EIF2AK4 PPP6R3

1.65e-059101031236736316
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

MAP3K3 GSR LRCH3 TGFB2 FASN PLEKHA3 MACF1 GOLGA3 ALG13

1.74e-05496103931343991
Pubmed

Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.

HTR2A HTR2B

2.60e-053103228258217
Pubmed

Overexpression of Fatty Acid Synthase Upregulates Glutamine-Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth.

APC FASN

2.60e-053103238732103
Pubmed

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

HTR2A HTR2B

2.60e-053103218703043
Pubmed

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.

HTR2A HTR2B

2.60e-053103215831837
Pubmed

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

SHC1 MET

2.60e-05310327731718
Pubmed

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.

MET FASN

2.60e-053103226857837
Pubmed

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.

HTR2A HTR2B

2.60e-05310327582481
Pubmed

5-HT2 receptors facilitate JC polyomavirus entry.

HTR2A HTR2B

2.60e-053103224089568
Pubmed

Three-dimensional structure of the armadillo repeat region of beta-catenin.

APC JUP

2.60e-05310329298899
Pubmed

The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).

APC XPO1

2.60e-053103212070164
Pubmed

Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.

SHC1 MET

2.60e-053103224708867
Pubmed

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.

HTR2A HTR2B

2.60e-053103219057895
Pubmed

Serotonin and the 5-HT(2B) receptor in the development of enteric neurons.

HTR2A HTR2B

2.60e-053103210627607
Pubmed

New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing.

XPO1 MACF1

2.60e-053103233036707
Pubmed

Expression of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in the mouse embryo.

HTR2A HTR2B

2.60e-053103210978843
Pubmed

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes.

HTR2A HTR2B

2.60e-053103229145495
Pubmed

Plakoglobin is required for effective intermediate filament anchorage to desmosomes.

JUP PKP1

2.60e-053103218496566
Pubmed

Serotonin signals through a gut-liver axis to regulate hepatic steatosis.

HTR2A HTR2B

2.60e-053103230446669
Pubmed

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.

APC JUP

2.60e-053103211707392
Pubmed

Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells.

HTR2A HTR2B

2.60e-053103224570000
Pubmed

Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression.

APC TGFB2

2.60e-053103221207416
Pubmed

Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes.

HTR2A HTR2B

2.60e-05310321381232
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

AKAP6 HSPH1 APC XPO1 RYR3 SARAF

2.62e-05195103617110338
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

SYNE1 APC MACF1

2.77e-0520103321689717
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

GAPVD1 SAAL1 SYNE1 APC XPO1 FAAP100 SPAG5 CEP350 DHX15 FASN ZNF451 CTNNBL1 EHMT1

3.76e-0511551031320360068
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

RAPGEF6 TMEM94 DZIP1 LRCH3 MET JUP MACF1 GOLGA3

3.76e-05421103836976175
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

GAPVD1 UBAP2 MYCBP2 APC TEX10 TRRAP LRCH3 PPP6R3

5.13e-05440103834244565
Pubmed

Crystal structure of a beta-catenin/Tcf complex.

APC JUP

5.19e-054103211136974
Pubmed

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

RIPK2 APC

5.19e-054103225036629
Pubmed

Modulation of serotonergic receptor signaling and cross-talk by prion protein.

HTR2A HTR2B

5.19e-054103215590675
Pubmed

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

SHC1 MET

5.19e-054103226551075
Pubmed

Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

HTR2A HTR2B

5.19e-054103211150294
Pubmed

High-fructose corn syrup enhances intestinal tumor growth in mice.

APC FASN

5.19e-054103230898933
Pubmed

Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis.

TEP1 MET

5.19e-054103218938767
Pubmed

Post-translational modifications regulate distinct functions of CARMA1 and BCL10.

RIPK2 CARD11

5.19e-054103217468049
Pubmed

Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.

APC JUP

5.19e-05410328074697
Pubmed

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.

APC JUP

5.19e-054103211348595
Pubmed

Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.

SHC1 MET

5.19e-05410329660480
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

GAPVD1 MYCBP2 SYNE1 XPO1 TEX10 TRRAP CEP350 DHX15 JUP FASN PKP1 MACF1

5.20e-0510241031224711643
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AKAP6 THSD7A MYCBP2 SYNE1 EHMT1 MACF1

5.81e-05225103612168954
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

FAM193B MYCBP2 ZSWIM5 TMEM94 KIAA0586 FAAP100 PABIR2 MAP3K3 TCAIM ZNF451 EIF2AK4 CFAP46 PPP6R3

6.30e-0512151031315146197
Pubmed

Tagging genes with cassette-exchange sites.

CDC42BPG BNC2 ZSWIM6 EHMT1 MACF1 PPP6R3 ZNF292

6.49e-05335103715741177
Pubmed

Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.

SYNE1 EPG5 GRIN3A

7.01e-0527103318649358
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

MYCBP2 TRRAP CEP350 MACF1

7.90e-0576103427542412
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GAPVD1 HIVEP1 ATR SYNE1 HSPH1 KIAA0586 XPO1 GSR DHX15 JUP FASN CTNNBL1 EHMT1 PKP1

8.04e-0514251031430948266
Pubmed

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

ZNF335 NAV3 EHMT1 PPP6R3

8.31e-0577103419505873
Pubmed

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.

APC MACF1

8.64e-055103217113391
Pubmed

Defining the interactions between intermediate filaments and desmosomes.

JUP PKP1

8.64e-05510329606214
Pubmed

The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.

APC JUP

8.64e-05510327890674
Pubmed

Expression and interaction of different catenins in colorectal carcinoma cells.

APC JUP

8.64e-055103211712088
Pubmed

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

APC MET

8.64e-055103228716720
Pubmed

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.

ATR SHC1

8.64e-055103210749680
Pubmed

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells.

HTR2A HTR2B

8.64e-05510329165122
Pubmed

The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.

APC JUP

8.64e-05510327651399
Pubmed

An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors.

HTR2A HTR2B

8.64e-05510328833759
Pubmed

The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners.

JUP PKP1

8.64e-055103219136012
Pubmed

Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein.

SHC1 MET

8.64e-05510328662733
Pubmed

Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.

TGFB2 MACF1 GRIN3A

8.72e-0529103318239623
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

MYCBP2 SYNE1 APC XPO1 TEX10 TRRAP DHX15 CTNNBL1 EHMT1 MACF1 PPIP5K2 ZNF292

8.78e-0510821031238697112
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

AKAP6 SYNE1 ZNF451 MACF1 BICRAL

8.97e-05151103517043677
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

HSPH1 GSR CEP350 DHX15 JUP FASN EHMT1

9.65e-05357103737059091
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

GAPVD1 RAPGEF6 HIVEP1 ATR MYCBP2 XPO1 TRRAP FASN ZNF335 PPP6R3

1.03e-047741031015302935
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

FAM193B GAPVD1 RAPGEF6 UBAP2 HSPH1 SPAG5 GSR JUP FASN MACF1 PPP6R3

1.04e-049341031133916271
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FAM193B THSD7A HSPH1 KIAA0586 CEP350 CMIP MACF1 GRIN3A

1.13e-04493103815368895
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

UBAP2 HSPH1 ZBTB47 XPO1 DHX15 GPR161 FASN PPP6R3

1.14e-04494103826831064
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

GAPVD1 RAPGEF6 MYCBP2 LRCH3 DHX15 PPP6R3

1.16e-04255103615324660
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

MYCBP2 HSPH1 APC XPO1 TRRAP GSR DHX15 MET JUP FASN EHMT1 MACF1 PPP6R3

1.21e-0412971031333545068
Pubmed

Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library.

JUP ZNF451 PPP6R3

1.29e-0433103323718855
Pubmed

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

APC ZNF292

1.29e-046103225559195
Pubmed

Molecular characterization of oral squamous cell carcinoma using targeted next-generation sequencing.

APC MET

1.29e-046103226173098
Pubmed

Genetic predictors of depressive symptoms in cardiac patients.

HTR2A VCAM1

1.29e-046103218618671
InteractionYWHAG interactions

GAPVD1 RAPGEF6 HIVEP1 UBAP2 MYCBP2 HSPH1 RIPK2 SHC1 APC DZIP1 XPO1 TRRAP PABIR2 TESPA1 MAP3K3 LRCH3 CEP350 DHX15 JUP PLEKHA3 MACF1 PPIP5K2 PPP6R3

2.22e-0812489823int:YWHAG
InteractionKDM1A interactions

GAPVD1 RAPGEF6 HIVEP1 MYCBP2 SHC1 APC XPO1 TRRAP SPAG5 CEP350 CRYAA DHX15 JUP FASN ZNF451 ZNF641 EHMT1 GOLGA3 PPP6R3

1.14e-079419819int:KDM1A
InteractionYWHAH interactions

CDC42BPG GAPVD1 RAPGEF6 HIVEP1 UBAP2 MYCBP2 HSPH1 RIPK2 APC DZIP1 XPO1 PABIR2 TESPA1 MAP3K3 CEP350 JUP PLEKHA3 MACF1 PPIP5K2

1.26e-0611029819int:YWHAH
InteractionYWHAB interactions

GAPVD1 RAPGEF6 HIVEP1 MYCBP2 HSPH1 RIPK2 APC DZIP1 TRRAP PABIR2 TESPA1 MAP3K3 CEP350 DHX15 MACF1 PPIP5K2 VCAM1

7.20e-0610149817int:YWHAB
InteractionDTNBP1 interactions

AKAP6 SYNE1 XPO1 SPAG5 MACF1 BICRAL TSKS

1.43e-05162987int:DTNBP1
InteractionGSK3A interactions

FAM193B GAPVD1 RAPGEF6 KIAA0586 APC SPAG5 CEP350 DHX15 MACF1 GOLGA3 PPP6R3

1.58e-054649811int:GSK3A
InteractionVSIG2 interactions

SAAL1 VSIG2 ATR XPO1

1.70e-0532984int:VSIG2
InteractionGSK3B interactions

FAM193B GAPVD1 RAPGEF6 HSPH1 KIAA0586 APC XPO1 SPAG5 CEP350 MET FASN MACF1 TSKS GOLGA3 PPP6R3

1.87e-058689815int:GSK3B
InteractionYWHAE interactions

GAPVD1 RAPGEF6 HIVEP1 MYCBP2 RIPK2 SHC1 APC ZC3HC1 XPO1 PABIR2 TESPA1 MAP3K3 LRCH3 JUP PLEKHA3 MACF1 GOLGA3 VCAM1

3.13e-0512569818int:YWHAE
InteractionZYX interactions

KIAA0586 APC XPO1 SPAG5 CEP350 DHX15 MACF1 VCAM1 ALG13

3.25e-05329989int:ZYX
InteractionYWHAZ interactions

CDC42BPG GAPVD1 RAPGEF6 HIVEP1 MYCBP2 APC DZIP1 XPO1 PABIR2 TESPA1 MAP3K3 SPAG5 JUP PLEKHA3 MACF1 PPIP5K2 GOLGA3 VCAM1

5.92e-0513199818int:YWHAZ
InteractionHDAC1 interactions

GAPVD1 RAPGEF6 HIVEP1 ATR MYCBP2 HSPH1 APC XPO1 SPAG5 LRCH3 JUP FASN EHMT1 GOLGA3 PPP6R3 HR

8.37e-0511089816int:HDAC1
InteractionBRCA1 interactions

MMS22L GAPVD1 HIVEP1 UBAP2 ATR HSPH1 ZBTB47 XPO1 FAAP100 MAP3K3 SPAG5 CEP350 DHX15 GPR161 JUP FASN PPP6R3

1.01e-0412499817int:BRCA1
Cytoband1p32-p31

MACF1 VCAM1

1.78e-04910321p32-p31
GeneFamilyZinc fingers SWIM-type|Mitogen-activated protein kinase kinase kinases

ZSWIM5 ZSWIM6

4.10e-04962290
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

APC JUP PKP1

4.30e-0443623409
GeneFamily5-hydroxytryptamine receptors, G protein-coupled

HTR2A HTR2B

8.81e-0413622170
GeneFamilyAquaporins

AQP12A AQP12B

1.03e-0314622305
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

GAPVD1 HIVEP1 ATR MYCBP2 APC XPO1 TRRAP CEP350 DHX15 TGFB2 ZNF451 NAV3 MACF1 BICRAL PPIP5K2 ZNF292

2.00e-0785610216M4500
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

GAPVD1 HIVEP1 ATR MYCBP2 XPO1 TRRAP CEP350 DHX15 TGFB2 ZNF292

1.42e-0546610210M13522
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

RAPGEF6 HIVEP1 MYCBP2 HSPH1 KIAA0586 APC XPO1 SPAG5 FASN MACF1 EIF2AK4 ZNF292

1.24e-055649912Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasalpha beta T cells, T.8Nve.PP, TCRb+ CD8+ CD44low CD62L high, Peyer's Patch, avg-1

RAPGEF6 RUNDC3B HSPH1 DZIP1 TESPA1 CEP350 MACF1 SARAF ZNF292

2.77e-05336999GSM538413_500
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

MMS22L SAAL1 ATR ZSWIM5 HSPH1 KIAA0586 APC XPO1 TEX10 SPAG5 LRCH3 CEP350 FASN PRELID3A PKP1 MACF1 ZNF292

6.59e-0512579917facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

UNC13B SAAL1 THSD7A OSTM1 ZSWIM5 HSPH1 KIAA0586 APC SPAG5 LRCH3 FASN CFAP54 PRELID3A MACF1 ZNF292

1.13e-0410609915facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

MMS22L SAAL1 ATR ZSWIM5 HSPH1 KIAA0586 APC XPO1 TEX10 SPAG5 LRCH3 CEP350 FASN PRELID3A PKP1 MACF1 VCAM1 ZNF292

1.27e-0414599918facebase_RNAseq_e10.5_Emin_LatNas_2500
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MMS22L GAPVD1 MYCBP2 XPO1 MACF1 VCAM1 ZNF292

2.61e-0718610378571956890fc9894d766ba294a28e376b4aba428
ToppCellBL-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP13A4 VSIG2 ABCA12 TGFB2 CAPN8 MET PTPRH

3.02e-071901037f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

MMS22L GAPVD1 OSTM1 MYCBP2 XPO1 MACF1 ZNF292

3.13e-0719110379454f642c3621370fa23640b631301346b300950
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ATP13A4 THSD7A TGFB2 CAPN8 MET

2.81e-061701036a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

MMS22L GAPVD1 MYCBP2 XPO1 MACF1 ZNF292

4.58e-061851036a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 SYNE1 LGSN CFAP54 ULK4 CFAP46

6.56e-06197103674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13B ATP13A4 SYNE1 CAPN8 MET FASN

6.95e-0619910362dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellParenchyma_COVID-19-Epithelial-TX-AT2-1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

UNC13B ATP13A4 VSIG2 CAPN8 MET FASN

7.15e-062001036cf1991853e10c562edae9a0d71a209f35b07db80
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYCBP2 XPO1 CEP350 JUP MACF1 ZNF292

7.15e-06200103612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT2-1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UNC13B ATP13A4 VSIG2 CAPN8 MET FASN

7.15e-0620010367618ae284625c5c121bcc00eb9f07e5b1e3adf23
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT2-1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

UNC13B ATP13A4 VSIG2 CAPN8 MET FASN

7.15e-06200103623b319bf7e5ae03e5baa777c951da9bfc97cca8c
ToppCell356C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FAM193B KIAA0586 TEP1 ZNF335 TSKS

1.62e-051361035edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell356C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FAM193B KIAA0586 TEP1 ZNF335 TSKS

1.62e-05136103503e4e2353c23ceffde35b2d0aadd15299e3db09f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAPGEF6 HTR2B TESPA1 CFAP54 SARAF

3.43e-051591035b9d34b9ed8db798f5ea93c44b469cae499403cb8
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ATP13A4 LGSN MET CFAP54 CFAP46

4.09e-0516510350c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ATP13A4 LGSN MET CFAP54 CFAP46

4.09e-05165103582530f96aaefe28a13bad0474bbad043f127a86c
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

BNC2 SYNE1 TGFB2 CFAP54 VCAM1

4.98e-05172103536a96714a0eb6ac438648135336c9791881ddadb
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR2A THSD7A ABCA12 RYR3 MET

5.12e-0517310352e35bf2b5534a289d93a09faae660f665c131062
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ATP13A4 THSD7A TGFB2 MET

6.02e-051791035cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

ATP13A4 CAPN8 MET JUP PKP1

6.34e-0518110356d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 SYNE1 CFAP54 NAV3 VCAM1

6.34e-0518110355f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 SYNE1 CFAP54 NAV3 VCAM1

6.34e-051811035c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

UNC13B ATP13A4 LGSN CAPN8 MET

6.34e-051811035c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

ATP13A4 SYNE1 CAPN8 MET FASN

6.68e-0518310358e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 ABCA12 RYR3 CAPN8 NAV3

6.86e-0518410352cbed6462fea2622871bb7e49b0df3d984239281
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

UNC13B ATP13A4 CAPN8 MET FASN

6.86e-051841035369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 ABCA12 RYR3 CAPN8 NAV3

6.86e-051841035ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 ABCA12 RYR3 CAPN8 NAV3

6.86e-0518410352b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ATP13A4 THSD7A CAPN8 MET

7.04e-05185103598b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell|TCGA-Uvea / Sample_Type by Project: Shred V9

HTR2B HSPH1 SHC1 TEP1 CARD11

7.22e-051861035e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCellCOPD-Epithelial-Club|World / Disease state, Lineage and Cell class

UNC13B ATP13A4 CAPN8 MET JUP

7.22e-0518610353006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

UNC13B ATP13A4 CAPN8 MET FASN

7.59e-051881035c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ATP13A4 VSIG2 ABCA12 CAPN8 PKP1

7.59e-05188103561422c7919ca0ea02d6be4302f11b169a3ce35e5
ToppCellCOVID-19-kidney-T-cells-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MMS22L HSPH1 TESPA1 FAM111B CARD11

7.59e-05188103515484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

ATP13A4 VSIG2 ABCA12 CAPN8 PKP1

7.59e-05188103518698f0b22ccbc2b93759acc1c8dbdb30a6b5a16
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

AKAP6 UNC13B MYCBP2 RYR3 JUP

7.78e-0518910353717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCellSevere_COVID-19-Epithelial-undefined_Epi|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

THSD7A VSIG2 CAPN8 MET PTPRH

7.78e-0518910358cbd35320c7e7ff013ef0c0f13f8d875db1c53cd
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13B ATP13A4 CAPN8 MET FASN

7.98e-05190103527a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellIPF-Epithelial-Goblet|IPF / Disease state, Lineage and Cell class

ATP13A4 VSIG2 CAPN8 MET JUP

7.98e-051901035e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCellIPF-Epithelial-Goblet|World / Disease state, Lineage and Cell class

ATP13A4 VSIG2 CAPN8 MET JUP

7.98e-051901035c29dabf0826663b9d6df51a7af9b76592090e44c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ATP13A4 CAPN8 MET FASN

8.18e-051911035a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

UNC13B ATP13A4 CAPN8 MET FASN

8.18e-051911035276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellCOPD-Epithelial|COPD / Disease state, Lineage and Cell class

ATP13A4 CAPN8 MET JUP CFAP46

8.38e-0519210350644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A MET JUP KBTBD12 ABTB2

8.38e-051921035f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

UNC13B ATP13A4 CAPN8 MET FASN

8.38e-05192103558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNC13B SYNE1 CAPN8 MET FASN

8.59e-051931035fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 SYNE1 CAPN8 MET JUP

8.59e-051931035f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

AKAP6 SYNE1 CFAP54 ULK4 CFAP46

8.59e-051931035ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

THSD7A SYNE1 LRCH3 MACF1 ZNF292

8.59e-0519310359337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNC13B SYNE1 CAPN8 MET FASN

8.59e-051931035f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B CDC42BPG VSIG2 CAPN8 MET

8.59e-05193103544839a606ae2f8e37421bda46d588189e1c943d2
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 SYNE1 CAPN8 MET JUP

8.59e-05193103542df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 ATP13A4 SYNE1 MET JUP

8.80e-051941035e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B SYNE1 CAPN8 MET FASN

8.80e-05194103597534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 SYNE1 CFAP54 ULK4 CFAP46

8.80e-0519410354a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR2A THSD7A HSPH1 GPR161 MET

9.01e-051951035787e95fb59c40bba784544b662fac37606ae1427
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SYNE1 MET CFAP54 MACF1 CFAP46

9.23e-051961035af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SYNE1 MET CFAP54 MACF1 CFAP46

9.23e-0519610356d02d494196e3f857d53eea46d9419690d43beca
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CAPN8 MET JUP NPC1L1 PKP1

9.46e-051971035751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Basal_1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CAPN8 MET JUP NPC1L1 PKP1

9.46e-0519710352701864e49878c5f323f5133e2c4b0a5a7fff7f5
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CAPN8 MET JUP NPC1L1 PKP1

9.46e-05197103558d809ccb8cc4b1e76acf0b8f996cd0e2637290c
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BNC2 SYNE1 ZNF451 MACF1 ZNF292

9.92e-051991035f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellT_cells-CCR7+_T_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

RAPGEF6 HSPH1 TESPA1 SARAF ALG13

9.92e-051991035467820d6abe3024d9d655b9672c2f9cdc1303db3
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BNC2 MYCBP2 SYNE1 MACF1 VCAM1

9.92e-051991035a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 VSIG2 CAPN8 MET FASN

9.92e-051991035a38a981cffa61c8444a980916de7414e689a1b63
ToppCellBiopsy_Control_(H.)-Epithelial-Transitional_AT2|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ATP13A4 VSIG2 CAPN8 MET JUP

9.92e-051991035e04a57a55c724091db353e2b3baf84372d788728
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ATP13A4 SYNE1 APC RYR3 MACF1

1.02e-04200103507d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ATP13A4 SYNE1 APC RYR3 MACF1

1.02e-042001035d0812817ef99608994193787a62d39adeb2070ca
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

UNC13B ATP13A4 CAPN8 MET FASN

1.02e-042001035acc771a902cf2f060c3eb9aedb72a256f5778a6c
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 VSIG2 CAPN8 MET FASN

1.02e-042001035b2d61bc3afac0d78aa30082760da5b1a15d1fad2
ToppCellParenchyma_COVID-19-Epithelial-TX-AT2-2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

UNC13B ATP13A4 CAPN8 MET FASN

1.02e-042001035ceb613ac6cdf0e3e6bb3f04d89034e18a524cefb
ToppCellParenchymal-10x5prime-Epithelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 VSIG2 CAPN8 MET FASN

1.02e-0420010354e5b6cb014d9bcb58e13c7511c86c43e27c496e4
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UNC13B ATP13A4 CAPN8 MET FASN

1.02e-042001035eb44d1f80ecaac3a022cd04ab16dc36151e45488
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ATP13A4 SYNE1 APC RYR3 MACF1

1.02e-042001035cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Myxofibrosarcoma-4|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

MAP3K3 PTPRH GALNTL5 TSKS

1.91e-04123103412b87d06e62f142e18424aae5c87454e78e713f0
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

SYNE1 CEP350 MACF1 ZNF292

1.35e-0449584GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
DrugBenzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

APC DZIP1 FAAP100 TESPA1 TGFB2 GPR161 PKP1 HR

2.87e-0619810183738_DN
DrugNialamide [51-12-7]; Down 200; 13.4uM; PC3; HT_HG-U133A

APC DZIP1 TEP1 FAAP100 PRELID3A NAV3 PKP1 BICRAL

3.10e-0620010184525_DN
Drugseganserin

HTR2A HTR2B CTNNBL1

9.94e-06101013CID000071767
DiseaseIntellectual Disability

AKAP6 TMEM94 SYNE1 APC TRRAP FASN ZNF335 MACF1 ZNF292 ALG13

3.24e-0644710110C3714756
DiseaseBenign neoplasm of stomach

ATR APC MET

2.56e-05171013C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ATR APC MET

2.56e-05171013C0496905
DiseaseCarcinoma in situ of stomach

ATR APC MET

2.56e-05171013C0154060
Diseaseanorexia nervosa (is_implicated_in)

AKAP6 HTR2A

3.47e-0531012DOID:8689 (is_implicated_in)
DiseaseStomach Carcinoma

ATR APC MET

4.95e-05211013C0699791
Diseasebreast cancer (implicated_via_orthology)

ATR APC MET

8.48e-05251013DOID:1612 (implicated_via_orthology)
DiseaseInsulinogenic index measurement

MYCBP2 PPIP5K2

1.15e-0451012EFO_0009961
Diseasesexual dimorphism measurement

GAPVD1 RAPGEF6 APC MAP3K3 TGFB2 CMIP ZNF335 ULK4 MACF1 CARD11 RMC1 PPP6R3

4.01e-04110610112EFO_0021796
Diseasehepatocellular carcinoma (is_implicated_in)

APC XPO1 TEP1 RYR3 MET

4.04e-041811015DOID:684 (is_implicated_in)
DiseaseHEPATOCELLULAR CARCINOMA

APC MET

4.11e-0491012114550
DiseaseHepatocellular carcinoma

APC MET

4.11e-0491012cv:C2239176
DiseaseCongenital Heart Defects

TMEM94 TRRAP TGFB2

4.66e-04441013C0018798
Diseasemedulloblastoma (is_implicated_in)

APC GPR161

5.13e-04101012DOID:0050902 (is_implicated_in)
Diseasecomparative body size at age 10, self-reported

AKAP6 RIPK2 ZSWIM6 CMIP CTNNBL1 RMC1 PPP6R3

6.14e-044201017EFO_0009819
Diseasecolon cancer (implicated_via_orthology)

ATR APC

6.25e-04111012DOID:219 (implicated_via_orthology)
Diseasecolorectal cancer (is_implicated_in)

APC XPO1 TGFB2 CTNNBL1

8.08e-041211014DOID:9256 (is_implicated_in)
DiseaseMalignant Neoplasms

ATR APC MET FASN

9.97e-041281014C0006826
DiseaseSarcomatoid Renal Cell Carcinoma

FAM111B MET NAV3 CARD11

9.97e-041281014C1266043
DiseaseChromophobe Renal Cell Carcinoma

FAM111B MET NAV3 CARD11

9.97e-041281014C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

FAM111B MET NAV3 CARD11

9.97e-041281014C1266044
DiseasePapillary Renal Cell Carcinoma

FAM111B MET NAV3 CARD11

9.97e-041281014C1306837
DiseaseRenal Cell Carcinoma

FAM111B MET NAV3 CARD11

9.97e-041281014C0007134
Diseaseovarian neoplasm

BNC2 ATR MET FASN

1.18e-031341014C0919267
Diseasebody weight

AKAP6 UNC13B MMS22L GAPVD1 HIVEP1 RIPK2 ZSWIM6 TEX10 TGFB2 FASN ULK4 RMC1

1.26e-03126110112EFO_0004338
DiseaseMalignant neoplasm of ovary

BNC2 ATR MET FASN

1.28e-031371014C1140680
Diseasevisceral adipose tissue measurement

AKAP6 BNC2 MMS22L RIPK2 ULK4 RMC1 GOLGA3

1.35e-034811017EFO_0004765
Diseasebody fat percentage

BNC2 MMS22L HIVEP1 TEX10 ULK4 MACF1 HR

1.47e-034881017EFO_0007800
DiseaseEye Abnormalities

APC TGFB2

1.53e-03171012C0015393
Diseaseparental longevity

GAPVD1 ZC3HC1 RYR3 CEP350 DHX15 C3P1 GALNTL5

1.57e-034941017EFO_0007796
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

BNC2 MMS22L HIVEP1 TEX10 MACF1 HR

1.60e-033641016EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

FAM111B MET NAV3 CARD11

1.70e-031481014C0279702
Diseaserenal cell carcinoma (is_implicated_in)

APC MET JUP

1.73e-03691013DOID:4450 (is_implicated_in)
Diseaseautism spectrum disorder (implicated_via_orthology)

HTR2A HTR2B MET PKP1

1.88e-031521014DOID:0060041 (implicated_via_orthology)
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

SHC1 VCAM1

1.91e-03191012DOID:1168 (biomarker_via_orthology)
DiseaseAutistic Disorder

HTR2A APC TRRAP MET ZNF292

2.07e-032611015C0004352
Diseasediastolic blood pressure, systolic blood pressure

UNC13B BNC2 GAPVD1 CEP350 DHX15 MET CMIP ULK4

2.15e-036701018EFO_0006335, EFO_0006336
Diseasetaste liking measurement

MMS22L GAPVD1 THSD7A MYCBP2 PPIP5K2 RMC1

2.21e-033881016EFO_0010155
Diseaseperiodontitis (biomarker_via_orthology)

MET VCAM1

2.33e-03211012DOID:824 (biomarker_via_orthology)
DiseaseColorectal Carcinoma

AKAP6 UNC13B ABCA12 SYNE1 APC TSKS ZNF292 HR

2.86e-037021018C0009402

Protein segments in the cluster

PeptideGeneStartEntry
ILESASTNQTSMYLC

TRBV28

96

A0A5B6
SMNSSEEICLLTTFA

EPG5

766

Q9HCE0
TLVLCDSCNQTTLQM

HTR2B

346

P41595
STIEATSNCTDLLKM

CFAP54

1836

Q96N23
TANLSLQDRKSCSMS

ALG13

816

Q9NP73
SDLHLLQSLMAQSCS

AQP12A

126

Q8IXF9
ENLFDSLCSCLMLSS

CTNNBL1

311

Q8WYA6
LNMEESVTISSCDLL

EIF2AK4

1386

Q9P2K8
RDLTLRDSCTDNSMQ

BNC2

66

Q6ZN30
ACTVQNESISELTMS

ATP13A4

1006

Q4VNC1
CLSNMTLLESSLQEL

ABCA12

211

Q86UK0
LSHLMQNTCLSSNDI

DEPDC4

101

Q8N2C3
VLRSFDSMISTNCTE

GSR

266

P00390
MDILCEENTSLSSTT

HTR2A

1

P28223
SLCSLNMNSTKLSAD

CMIP

736

Q8IY22
ALSQSCSASETMRDV

CFAP46

2086

Q8IYW2
NINTCREMISLLDSN

CAPN8

576

A6NHC0
SDLHLLQSLMAQSCS

AQP12B

126

A6NM10
YNCSNEVLSITAMLS

DHX15

581

O43143
SCLRLNTNGMVDSSV

CDC42BPG

216

Q6DT37
TDDSALCMSLSGLNQ

LRCH3

541

Q96II8
MENCSAASTFLTDSL

MMS22L

1

Q6ZRQ5
CSTIMNLLSLANEDS

GAPVD1

1401

Q14C86
LMSSNSTDLPLNIEC

HSPH1

276

Q92598
ACSLMLTQFVSSQAL

HR

656

O43593
GEQASMSCRSSQSLL

IGKV2D-26

36

A0A0A0MRZ7
ETESSMLSCQLALKS

NAV3

46

Q8IVL0
NSLTSMGNVVTCELS

MACF1

696

O94854
SDNSSTAMLTDCIQQ

KCNK10

496

P57789
TSESQSCARSLLMAD

OSTM1

136

Q86WC4
DVLMATCVLENSSSF

FAAP100

521

Q0VG06
LSLPMQETQLCSTDS

GOLGA3

126

Q08378
RTMQNTSDLDTARCT

JUP

191

P14923
QLCLDPMTNDSSTLD

GRIN3A

541

Q8TCU5
MLSPDAAQLSDLSSC

PABIR2

186

Q7Z309
SGSLMTLSNVSCLSN

NPC1L1

46

Q9UHC9
SDLCQLSTQTVFSML

ATR

1571

Q13535
SSILADSHLEMTCNN

BICRAL

956

Q6AI39
TTQVLSLSSLCDMAN

C3P1

211

Q6ZMU1
IRASFSVCELSMDSN

FAM193B

566

Q96PV7
ECNALFQTMSSVTNL

GALNTL5

146

Q7Z4T8
LCKRQTDSSSSDMQA

CEP350

951

Q5VT06
ATMCSAQDRTDLLNV

FOLR2

16

P14207
MSLNSSLSCRKELSN

GPR161

1

Q8N6U8
LCGEQMTTSTSNQTL

KLF18

821

A0A0U1RQI7
QSALSCSLSADGMLT

CRYAA

126

P02489
MTANSVSVATCEQLT

FAM111B

441

Q6SJ93
ALDTACSSSLMALQN

FASN

156

P49327
SICFIMSSSTNVDLL

SAAL1

186

Q96ER3
EITTLANNQCMATES

EHMT1

531

Q9H9B1
NLNISSQLDACTMSL

CARD11

781

Q9BXL7
SNSNDCMRDSSQILT

LGSN

51

Q5TDP6
QCMLDPLSSAENSLS

MAP3K3

211

Q99759
METTSLLLCIGNNSS

KBTBD12

271

Q3ZCT8
SSSMLNNIINLCRSS

PKP1

681

Q13835
GNESCTLTLSESTMN

MET

606

P08581
ICSIENMENVSSSRA

RUNDC3B

126

Q96NL0
SSILEEGSSVNMTCL

VCAM1

521

P19320
CSLSVEHIQSLNTNM

TCAIM

131

Q8N3R3
VSNCSVDSMSAALQD

RAPGEF6

1276

Q8TEU7
MTTELQSLCSLLQES

SPAG5

976

Q96R06
TEVMSSNSTLEQCTL

THSD7A

1541

Q9UPZ6
MDLCQALESLSSAIT

SYNE1

1596

Q8NF91
QSCLENLVSQMALSE

SYNE1

2941

Q8NF91
SSADSCNMSGLITIV

SARAF

166

Q96BY9
MELCSTNITLTNLVS

PRELID3A

91

Q96N28
SCMAQRTDAVLNIST

SHPK

266

Q9UHJ6
MNDSTGQSLTALSCA

MYCBP2

266

O75592
LLSSDQCSVSQMDTL

DZIP1

611

Q86YF9
ILCSQTLSMESAVNT

ABTB2

941

Q8N961
DTETTTNSEMCLLNA

AKAP6

1371

Q13023
SRTLLAMSSSQDSCI

APC

331

P25054
TVALSLSTCSTLDMD

TGFB2

16

P61812
SLESMQLSLITCSQC

ZC3HC1

261

Q86WB0
SLCSATAQNLTDMNT

ZNF451

756

Q9Y4E5
ASRTSESLCQNNMVI

XPO1

156

O14980
ASLSSSMNTANSLCL

UBAP2

756

Q5T6F2
ESQQCELASTMLTAA

ZSWIM5

801

Q9P217
QCSQRMLSFSDALLS

TMEM175

31

Q9BSA9
LLCSTLVSEVNMNNT

TEP1

251

Q99973
LSVCSQMLSESDRAS

RMC1

391

Q96DM3
DSSRDRNLTNCSSVM

TMEM94

1196

Q12767
QSLSGLMQSCSVLDL

RYR3

3681

Q15413
MTEACLNQSLDALLS

RIPK2

451

O43353
MALNSCTTSINSDLQ

ZNF292

1731

O60281
MVSLANASTLQKDCS

TEX10

441

Q9NXF1
LLLQGSSRDSCNDSM

UNC13B

226

O14795
SSACTNVSLLNLAAM

TSKS

76

Q9UJT2
SAASLLQMADIAASC

ZBTB47

91

Q9UFB7
AEVDCMSLLNTTLSS

SLC28A1

596

O00337
NMNEASSLLSATCNT

PLEKHA3

151

Q9HB20
ESQQCELASTMLTAA

ZSWIM6

831

Q9HCJ5
QLLDLGCSLASSSMT

TESPA1

126

A2RU30
MNGLLDSDSDSLSSC

PPIP5K2

601

O43314
NQMGSASCELTLSVT

VSIG2

221

Q96IQ7
NMLVSDCTASSSDLG

ZNF335

116

Q9H4Z2
SCELLTSDVSQMNDR

PPP6R3

81

Q5H9R7
NLHMETQTNSSIALC

PTPRH

391

Q9HD43
IDDESLPSSIQTMSC

TRRAP

406

Q9Y4A5
INCTQTSMEVSDLRS

HIVEP1

1371

P15822
VSTSSLNLMAADCKQ

SHC1

236

P29353
DCSQSLSLSTMQEDM

KIAA0586

1511

Q9BVV6
SSVEDLSLSRNTMEC

ULK4

291

Q96C45
DSFSNLLCSTEMDSL

ZNF641

246

Q96N77