Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	MYTH4	PLEKHH1 MYO7B	3.02e-04	9	55	2	PS51016
Domain	MyTH4_dom	PLEKHH1 MYO7B	3.02e-04	9	55	2	IPR000857
Domain	MyTH4	PLEKHH1 MYO7B	3.02e-04	9	55	2	PF00784
Domain	MyTH4	PLEKHH1 MYO7B	3.02e-04	9	55	2	SM00139
Domain	Pept_M10A_Zn_BS	MMP12 MMP15	8.72e-04	15	55	2	IPR021158
Domain	Hemopexin_CS	MMP12 MMP15	1.13e-03	17	55	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP12 MMP15	1.26e-03	18	55	2	IPR016293
Domain	PG_binding_1	MMP12 MMP15	1.56e-03	20	55	2	PF01471
Domain	Peptidoglycan-bd-like	MMP12 MMP15	1.56e-03	20	55	2	IPR002477
Domain	Hemopexin-like_dom	MMP12 MMP15	2.07e-03	23	55	2	IPR000585
Domain	Hemopexin-like_repeat	MMP12 MMP15	2.07e-03	23	55	2	IPR018487
Domain	M10A_MMP	MMP12 MMP15	2.07e-03	23	55	2	IPR033739
Domain	Hemopexin	MMP12 MMP15	2.07e-03	23	55	2	PF00045
Domain	HEMOPEXIN	MMP12 MMP15	2.07e-03	23	55	2	PS00024
Domain	-	MMP12 MMP15	2.07e-03	23	55	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP12 MMP15	2.07e-03	23	55	2	PS51642
Domain	HX	MMP12 MMP15	2.07e-03	23	55	2	SM00120
Domain	Pept_M10A	MMP12 MMP15	2.07e-03	23	55	2	IPR021190
Domain	Peptidase_M10	MMP12 MMP15	2.25e-03	24	55	2	PF00413
Domain	ZnMc	MMP12 MMP15	3.29e-03	29	55	2	SM00235
Domain	Peptidase_Metallo	MMP12 MMP15	3.29e-03	29	55	2	IPR006026
Domain	-	PLEKHH1 PLEKHG6 MYO7B OBSCN SH2B2	5.78e-03	391	55	5	2.30.29.30
Domain	CYSTEINE_SWITCH	MMP12 MMP15	6.49e-03	41	55	2	PS00546
Domain	SET	SETD6 NSD1	6.49e-03	41	55	2	PF00856
Domain	Pept_M10_metallopeptidase	MMP12 MMP15	7.12e-03	43	55	2	IPR001818
Domain	SET	SETD6 NSD1	8.11e-03	46	55	2	SM00317
Domain	FERM_M	PLEKHH1 MYO7B	8.11e-03	46	55	2	PF00373
Domain	PH_dom-like	PLEKHH1 PLEKHG6 MYO7B OBSCN SH2B2	8.23e-03	426	55	5	IPR011993
Domain	PH	PLEKHH1 PLEKHG6 OBSCN SH2B2	9.04e-03	278	55	4	SM00233
Domain	PH_DOMAIN	PLEKHH1 PLEKHG6 OBSCN SH2B2	9.15e-03	279	55	4	PS50003
Pubmed	Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.	SHBG ELANE	2.93e-06	2	60	2	24848868
Pubmed	Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.	ELANE MMP12	2.93e-06	2	60	2	14633606
Pubmed	Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology.	ELANE MMP12	8.77e-06	3	60	2	10187779
Pubmed	Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase.	FUT4 MMP12	1.75e-05	4	60	2	7559635
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RBM15 MYO7B NSD1 GIGYF2 CAMSAP1	5.34e-05	234	60	5	36243803
Pubmed	Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.	ELANE MMP12	6.11e-05	7	60	2	10859319
Pubmed	Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6.	FUT4 MMP12	6.11e-05	7	60	2	10760605
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP12 MMP15	1.59e-04	11	60	2	10949161
Pubmed	Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.	DDR1 MMP12	1.59e-04	11	60	2	7558021
Pubmed	Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.	ELANE MMP12	2.26e-04	13	60	2	25166912
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1D5 OR1D4	3.46e-04	16	60	2	10673334
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP12 MMP15	3.46e-04	16	60	2	10949577
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP12 MMP15	3.46e-04	16	60	2	37701782
Pubmed	Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.	MYO7B TBX1	4.91e-04	19	60	2	34124068
Pubmed	Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.	ELANE MMP12	5.45e-04	20	60	2	19590686
Pubmed	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.	TBC1D10C SGSM3	6.02e-04	21	60	2	17562788
Pubmed	Matrix metalloproteinases.	MMP12 MMP15	6.61e-04	22	60	2	10419448
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP12 MMP15	6.61e-04	22	60	2	23421805
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP12 MMP15	7.88e-04	24	60	2	15734845
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	EPHB6 MTG1 GIGYF2 ZFR DNAH7	7.94e-04	420	60	5	28065597
Pubmed	Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.	FUT4 TENM2	9.26e-04	26	60	2	15890332
Pubmed	A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.	BARD1 ELANE MMP12	1.22e-03	121	60	3	19789190
Pubmed	Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.	TBX1 KLHL22	1.49e-03	33	60	2	10704284
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	EPHB6 OVGP1 NSD1 FUT4 MMP12 MMP15	1.60e-03	730	60	6	34857952
Pubmed	Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.	ELANE SIRT6	1.68e-03	35	60	2	10984455
Cytoband	1p13	RBM15 OVGP1	2.26e-04	17	60	2	1p13
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	SHBG OR1D5 GLTPD2 OR1D4	1.11e-03	346	60	4	chr17p13
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP12 MMP15	1.15e-03	24	38	2	891
GeneFamily	Olfactory receptors, family 1	OR1D5 OR1D4	3.19e-03	40	38	2	147
GeneFamily	Fibronectin type III domain containing	EPHB6 OBSCN MYBPC1	4.57e-03	160	38	3	555
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PLEKHH1 MYO7B	4.94e-03	50	38	2	1293
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pcp2_(Purkinje_Neurons)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	HTR1F PRSS16 NUP210L B4GALNT3	4.85e-06	83	60	4	1ab841bab56a05dc0e7551a1408e5c5570f548e0
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pcp2_(Purkinje_Neurons)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	HTR1F PRSS16 NUP210L B4GALNT3	4.85e-06	83	60	4	7a38262bca74f0e26ac07d936753dc83fde3cb3d
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pcp2_(Purkinje_Neurons)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	HTR1F PRSS16 NUP210L B4GALNT3	4.85e-06	83	60	4	46de51665a1502f3132f2d56c85e8ba365431b3d
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D10C ZNF48 PLEKHG6 BARD1 FUT4	5.33e-06	187	60	5	5fae538de481367cf6d9a2d52190d77b99f6922c
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D10C ZNF48 PLEKHG6 BARD1 FUT4	5.33e-06	187	60	5	22fd1959879705a8c1128faa9de66696c4e0b7e3
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D10C ZNF48 PLEKHG6 BARD1 FUT4	5.33e-06	187	60	5	0526c0a818cf28fd5b6ff65fe260e3c3a4a98a2a
Disease	renal cell carcinoma	MYO7B DPF3 ZNF620	7.05e-05	42	56	3	EFO_0000681
Disease	creatinine measurement	NUDT3 DPF3 OBSCN NSD1 GIGYF2 SGSM3 MTX1 SH2B2	5.50e-04	995	56	8	EFO_0004518
Disease	uric acid measurement	PLEKHH1 DPF3 UNC5CL RBMS1 MTX1 TENM2	1.03e-03	610	56	6	EFO_0004761
Disease	Drugs used in diabetes use measurement	PIM3 NUDT3 NSD1 DNAH7	1.41e-03	255	56	4	EFO_0009924
Disease	clear cell renal cell carcinoma (is_marker_for)	DDR1 MMP12	1.80e-03	33	56	2	DOID:4467 (is_marker_for)
Disease	glomerular filtration rate, renal transplant outcome measurement	OR1D5 OR1D4	2.02e-03	35	56	2	EFO_0005199, EFO_0005208
Disease	non-high density lipoprotein cholesterol measurement	UNC5CL AKNA NSD1 B4GALNT3 MTX1 GLTPD2	2.27e-03	713	56	6	EFO_0005689
Disease	autism spectrum disorder, schizophrenia	DDR1 PRSS16 SETD6 GIGYF2	3.46e-03	327	56	4	EFO_0003756, MONDO_0005090
Disease	Tourette syndrome	RBMS1 TENM2	4.09e-03	50	56	2	EFO_0004895
Disease	Nasal Cavity Polyp	GIGYF2 TBX1	4.93e-03	55	56	2	EFO_1000391

Protein segments in the cluster

Peptide	Gene	Start	Entry
KERTRFTWMDGPPHG	LINC00242	76	Q5T6M2
RSAPAMEPDGRGAWA	BARD1	21	Q99728
MPPLFWRHQGTSRDD	HTR1F	156	P30939
DRMRPQAPGRGWHGE	B4GALNT3	576	Q6L9W6
RRGPAMAWEGEPMRH	DDR1	306	Q08345
LLHWLEREGYGPLGM	ABHD18	181	Q0P651
WRRHEAAAPAGAPLG	AMN	391	Q9BXJ7
GRAAAEGWRKMEAPP	CAMSAP1	6	Q5T5Y3
AWTHMRGFPLGGPDR	RBM15	506	Q96T37
WPASKGLGHMPRAVE	NSD1	2491	Q96L73
GRPWHREGEVRLAGM	RBMS1	241	P29558
DVHHFREMPGGPVWR	MMP12	96	P39900
MGVAARPPALRHWFS	GLTPD2	1	A6NH11
WMEKRHRGPGLAPGQ	DPF3	56	Q92784
RAEAALPVRAMGAPW	FUT4	116	P22083
MPIGHFWRGLPGDIS	MMP15	406	P51511
PLCGRDVARWFPGHM	MTG1	21	Q9BT17
RHPDRWIVPGGGMEP	NUDT3	41	O95989
IHVMRRWEGGDPGVS	HSPA12A	81	O43301
EGAPGARMPWKGHNR	OBSCN	5906	Q5VST9
AGERWADLAMGPRPH	QRFP	36	P83859
ADLAMGPRPHSVWGS	QRFP	41	P83859
FGMPRLPPEDRRHWE	PLEKHG6	116	Q3KR16
LADGPVRRAWHGMAT	KLHL22	476	Q53GT1
SPDGPRSAGWREHME	GIGYF2	236	Q6Y7W6
NPGLRPRHWEAMSAI	DNAH7	846	Q8WXX0
RGGGPHLEETWMASP	AKNA	906	Q7Z591
LWLEGGHRLFPPRMA	ITGA10	401	O75578
VGGRRARPHAWPFMV	ELANE	31	P08246
WHRGEPGHPRMEELN	KLHL30-AS1	46	Q8NEE0
GLTLVGLWDRRHPGM	NUP210L	1456	Q5VU65
GLWDRRHPGMADYIP	NUP210L	1461	Q5VU65
LYPGLRGSPMHDRWT	OVGP1	141	Q12889
MHGAPGRVLWRPFQR	OR1D4	296	P47884
MHGAPGRVLWRPFQR	OR1D5	296	P58170
VGHLWMGRRPPSPEA	MTX1	76	Q13505
CWLNGGAMPEARHPR	PPP1R12C	211	Q9BZL4
GPALGWNDPDRMLLR	SARAF	26	Q96BY9
DMRSRGVWGPIHELG	TCAF2	746	A6NFQ2
MLHWRLPRELGGRGD	EPHB6	386	O15197
PHGMRPQLWMRLSGA	SGSM3	116	Q96HU1
PKDDWFMLGLRDGRP	SHBG	91	P04278
GRLEHPMFWPEEERR	SETD6	151	Q8TBK2
GGMSPEHAIRLWGRG	TENM2	121	Q9NT68
GPHGVWTMEERGLAP	SIRT6	66	Q8N6T7
MKHLGLEIPAWDGPR	SIRT6	266	Q8N6T7
MAHPEPEGAVEGARW	SPATA25	186	Q9BR10
MAPLQLLHPWGRRGA	TLX1NB	1	P0CAT3
MERAVEPWGPDLHRP	ZNF48	1	Q96MX3
PGDPQWMETIGRDLH	TBC1D10C	126	Q8IV04
GLDPWEPMGREALRG	ZNF620	71	Q6ZNG0
WRPLGRPGAHASRDE	UNC5CL	206	Q8IV45
DGVRDMWHRRASPEP	SH2B2	146	O14492
RPSLDQIAAHPWMLG	PIM3	281	Q86V86
HLAPPMGADRWNALA	PIGZ	146	Q86VD9
GEGDPDSPLWRHPML	PLEKHH1	816	Q9ULM0
HHWDDRRRMPDGGYP	ZFR	676	Q96KR1
QLPMWLRGPDEEGVH	TRAPPC8	1031	Q9Y2L5
EDWPRNHRPGALPLM	TBX1	301	O43435
GEHMLRRGWPPHRTL	WDR7	446	Q9Y4E6
MRGHPAALAPAWGAL	PRSS16	111	Q9NQE7
MSGFRLGDHVWLEPP	MYO7B	1	Q6PIF6
MRWRPPDHIGAAGLD	MYBPC1	736	Q00872