Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBLN2 FBN1 FBN2

6.45e-0612633GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBLN2 FBN1 FBN2

1.06e-0514633GO:0097493
GeneOntologyMolecularFunctioncalcium ion binding

CACNA1B FBLN1 FAT1 FBLN2 FBN1 FBN2 MACF1 LTBP1 CPS1 LDLR RYR1

1.99e-057496311GO:0005509
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FBLN1 FBLN2 FBN1 FBN2 LTBP1

3.17e-04188635GO:0005201
GeneOntologyMolecularFunctionserotonin binding

HTR1F HTR2A

7.47e-0413632GO:0051378
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2 LTBP1

1.08e-074633GO:0035583
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2 LTBP1

1.50e-068633GO:0071694
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2 LTBP1

4.40e-0611633GO:0035581
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2 LTBP1

7.60e-0613633GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2 LTBP1

7.60e-0613633GO:1900116
GeneOntologyBiologicalProcessprotein localization to M-band

ANK2 OBSCN

9.18e-062632GO:0036309
GeneOntologyBiologicalProcessresponse to purine-containing compound

AKAP9 PRKAA2 BIRC2 CPS1 RYR1

1.53e-04166635GO:0014074
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 LTBP1

7.30e-0613633GO:0001527
GeneOntologyCellularComponentRNA polymerase III transcription regulator complex

BDP1 GTF3C1

3.17e-049632GO:0090576
MousePhenoabnormal B-2 B cell morphology

COG6 PIK3CD BACH2 FNIP1

1.81e-0541544MP:0008166
MousePhenodecreased marginal zone B cell number

COG6 PIK3CD BACH2 FNIP1

8.26e-0560544MP:0008182
MousePhenoincreased enzyme/coenzyme level

FBN2 PSAP AKAP9 LUC7L3 ARVCF COG6 DIPK1A BACH2 MKRN2 PRKAA2 PAK2 SPOP LDLR BTRC

8.37e-0511485414MP:0014448
MousePhenoabnormal KLRG1+ CD4 alpha-beta T cell number

COG6 BACH2

8.74e-054542MP:0013156
MousePhenoincreased KLRG1+ CD4 alpha-beta T cell number

COG6 BACH2

8.74e-054542MP:0013157
MousePhenoincreased KLRG1+ CD8 alpha-beta T cell number

COG6 BACH2

8.74e-054542MP:0013154
MousePhenoabnormal KLRG1+ CD8 alpha-beta T cell number

COG6 BACH2

1.45e-045542MP:0013153
MousePhenoalveolitis

FBN1 LYST

2.18e-046542MP:0010922
MousePhenodecreased Ly6C-positive immature NK cell number

COG6 BACH2

2.18e-046542MP:0013669
MousePhenodecreased memory-marker NK cell number

COG6 BACH2

2.18e-046542MP:0013426
MousePhenoabnormal enzyme/coenzyme level

FBN2 PSAP AKAP9 LUC7L3 ARVCF COG6 DIPK1A BACH2 MKRN2 PRKAA2 PAK2 LTBP1 SPOP LDLR BTRC

2.81e-0414515415MP:0005319
MousePhenoincreased KLRG1-positive NK cell number

COG6 BACH2

3.04e-047542MP:0012767
MousePhenoabnormal Ly6C-positive immature NK cell number

COG6 BACH2

3.04e-047542MP:0013668
MousePhenoabnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

COG6 BACH2

3.04e-047542MP:0013431
MousePhenoincreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

COG6 BACH2

3.04e-047542MP:0013433
MousePhenoincreased circulating enzyme level

FBN2 AKAP9 LUC7L3 ARVCF COG6 DIPK1A BACH2 MKRN2 PRKAA2 PAK2 SPOP LDLR BTRC

3.09e-0411405413MP:0014450
MousePhenodecreased B-2 B cell number

PIK3CD BACH2 FNIP1

3.55e-0436543MP:0008207
MousePhenooverexpanded pulmonary alveolus

FBLN1 FBN1 LYST

3.86e-0437543MP:0001183
MousePhenoabnormal platelet morphology

TUT4 FBN1 FBN2 COG6 KIAA0232 BACH2 PRKAA2 CPS1 LYST

4.39e-04600549MP:0004720
MousePhenoabnormal phagocyte morphology

BDP1 USP45 FBN1 PSAP COG6 PIK3CD BACH2 FNIP1 CPS1 LYST LDLR BTRC

4.68e-0410335412MP:0008251
MousePhenoabnormal marginal zone B cell morphology

COG6 PIK3CD BACH2 FNIP1

5.08e-0496544MP:0008180
MousePhenodecreased Ly6C-positive mature NK cell number

COG6 BACH2

5.18e-049542MP:0013675
MousePhenoincreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

COG6 BACH2

5.18e-049542MP:0013430
MousePhenoincreased memory-marker NK cell number

COG6 BACH2

5.18e-049542MP:0013427
MousePhenodecreased memory-marker CD4-negative NK T cell number

COG6 BACH2

5.18e-049542MP:0013513
MousePhenoabnormal circulating enzyme level

FBN2 AKAP9 LUC7L3 ARVCF COG6 DIPK1A BACH2 MKRN2 PRKAA2 PAK2 LTBP1 SPOP LDLR BTRC

5.42e-0413725414MP:0001570
MousePhenoimpaired lung alveolus development

FBLN1 FBN1 LYST

6.45e-0444543MP:0006027
MousePhenointracerebral hemorrhage

FBLN1 CFAP54 COG6

6.45e-0444543MP:0001916
MousePhenoabnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

COG6 BACH2

6.46e-0410542MP:0013428
MousePhenodecreased CD4-negative NK T cell number

COG6 BACH2

6.46e-0410542MP:0013510
MousePhenoabnormal neutrophil morphology

BDP1 USP45 FBN1 PIK3CD BACH2 FNIP1 CPS1 LYST

7.14e-04511548MP:0005065
MousePhenodecreased transitional stage B cell number

COG6 BACH2 FNIP1

7.35e-0446543MP:0008190
MousePhenoenhanced autophagy

PSAP FNIP1

7.88e-0411542MP:0030941
MousePhenoincreased Ly6C high monocyte number

COG6 BACH2

7.88e-0411542MP:0013022
MousePhenoabnormal grip strength

CACNA1B FBN2 LUC7L3 BACH2 SCAPER FNIP1 SPOP CPS1 LYST LDLR RYR1

8.34e-049465411MP:0001515
MousePhenoabnormal lung alveolus development

FBLN1 FBN1 LYST

9.39e-0450543MP:0010995
MousePhenoabnormal Ly6C-positive mature NK cell number

COG6 BACH2

9.43e-0412542MP:0013674
MousePhenoincreased skeletal muscle cell glucose uptake

ANK2 PRKAA2

9.43e-0412542MP:0031619
MousePhenoabnormal memory-marker NK cell number

COG6 BACH2

9.43e-0412542MP:0013425
MousePhenoostium secundum atrial septal defect

FBLN1 RYR1

9.43e-0412542MP:0010405
DomainEGF_CA

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

1.54e-0886637PF07645
DomaincEGF

FBLN1 FBLN2 FBN1 FBN2 LTBP1

2.31e-0826635IPR026823
DomaincEGF

FBLN1 FBLN2 FBN1 FBN2 LTBP1

2.31e-0826635PF12662
DomainEGF_Ca-bd_CS

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

3.57e-0897637IPR018097
DomainEGF_CA

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

4.12e-0899637PS01187
DomainASX_HYDROXYL

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

4.41e-08100637PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

6.62e-08106637IPR000152
DomainEGF_CA

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

1.74e-07122637SM00179
DomainEGF-like_Ca-bd_dom

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

1.95e-07124637IPR001881
DomainGrowth_fac_rcpt_

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

9.26e-07156637IPR009030
DomainTB

FBN1 FBN2 LTBP1

1.27e-067633PF00683
Domain-

FBN1 FBN2 LTBP1

2.02e-0686333.90.290.10
DomainTB

FBN1 FBN2 LTBP1

3.03e-069633PS51364
DomainTB_dom

FBN1 FBN2 LTBP1

3.03e-069633IPR017878
DomainEGF_3

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

1.39e-05235637PS50026
DomainEGF

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

1.39e-05235637SM00181
DomainEGF-like_dom

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

2.02e-05249637IPR000742
DomainEGF_1

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

2.35e-05255637PS00022
DomainEGF-like_CS

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

2.73e-05261637IPR013032
DomainEGF_2

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

3.00e-05265637PS01186
DomainFBN

FBN1 FBN2

3.35e-053632IPR011398
DomainARM-type_fold

RIF1 ARVCF PIK3CD MROH2A CTIF USP9Y LYST

1.41e-04339637IPR016024
DomainANATO

FBLN1 FBLN2

2.33e-047632SM00104
DomainANATO

FBLN1 FBLN2

2.33e-047632PF01821
DomainANAPHYLATOXIN_2

FBLN1 FBLN2

2.33e-047632PS01178
DomainANAPHYLATOXIN_1

FBLN1 FBLN2

2.33e-047632PS01177
DomainAnaphylatoxin/fibulin

FBLN1 FBLN2

2.33e-047632IPR000020
Domain5HT_rcpt

HTR1F HTR2A

3.97e-049632IPR002231
DomainMATH/TRAF_dom

SPOPL SPOP

7.23e-0412632IPR002083
DomainMATH

SPOPL SPOP

7.23e-0412632PS50144
DomainMATH

SPOPL SPOP

7.23e-0412632SM00061
DomainMATH

SPOPL SPOP

7.23e-0412632PF00917
DomainbZIP_Maf

BACH2 BACH1

8.53e-0413632IPR004826
DomainbZIP_Maf

BACH2 BACH1

8.53e-0413632PF03131
Domain-

SPOPL SPOP

9.93e-04146322.60.210.10
DomainBTB

SPOPL BACH2 BACH1 SPOP

1.00e-03131634PF00651
Domain-

BACH2 BACH1

1.30e-03166321.10.880.10
DomainBTB

SPOPL BACH2 BACH1 SPOP

2.09e-03160634PS50097
DomainTRAF-like

SPOPL SPOP

2.95e-0324632IPR008974
DomainBTB

SPOPL BACH2 BACH1 SPOP

3.19e-03180634SM00225
DomainDHHC

ZDHHC21 KMT2C

3.20e-0325632PS50216
DomainZnf_DHHC_palmitoyltrfase

ZDHHC21 KMT2C

3.20e-0325632IPR001594
DomainZF_RING_2

KMT2C VPS18 MKRN2 NFXL1 BIRC2

3.30e-03298635PS50089
DomainBTB/POZ_dom

SPOPL BACH2 BACH1 SPOP

3.52e-03185634IPR000210
DomainSKP1/BTB/POZ

SPOPL BACH2 BACH1 SPOP

3.80e-03189634IPR011333
DomainZnf_RING

KMT2C VPS18 MKRN2 NFXL1 BIRC2

4.83e-03326635IPR001841
DomainbZIP_1

BACH2 BACH1

5.86e-0334632PF00170
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN1 FBLN2 FBN1 FBN2 LTBP1

1.83e-0737505M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN1 FBLN2 FBN1 FBN2 LTBP1

4.47e-0744505M26969
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN2 FBN1 FBN2 LTBP1

4.68e-0632504MM14854
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN2 FBN1 FBN2 LTBP1

1.05e-0539504MM14601
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 LTBP1

9.14e-0525503M39713
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2 LTBP1

2.26e-08463312429738
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2 LTBP1

5.65e-08563334411563
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

DNAJA3 FBLN1 VPS18 TUT4 FBLN2 FBN1 COG6 KIAA0232 PEX19 LTBP1

6.43e-08560631021653829
Pubmed

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

FBLN2 FBN1 LTBP1

1.13e-07663319349279
Pubmed

EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.

FBLN1 FBLN2 FBN1

3.15e-07863332948785
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBLN1 FBN1 FBN2

4.72e-07963312122015
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

FBN1 FBN2 LTBP1

4.72e-07963338844137
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

FBLN1 FBLN2 FBN1 FBN2 LTBP1

5.16e-078663528327460
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

3.23e-06263212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

3.23e-06263221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

3.23e-06263212429739
Pubmed

Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration.

FBLN2 FBN1

3.23e-0626329886271
Pubmed

Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.

FBLN1 LTBP1

3.23e-06263231343988
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

3.23e-06263230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

3.23e-06263221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

3.23e-06263215131124
Pubmed

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

SPOPL SPOP

3.23e-06263216740475
Pubmed

Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo.

FBLN1 FBLN2

3.23e-0626328850569
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

3.23e-06263212524050
Pubmed

AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes.

PRKAA2 LDLR

3.23e-06263220167927
Pubmed

Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.

SPOPL SPOP

3.23e-06263220399258
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

3.23e-06263220404337
Pubmed

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.

FBN1 LTBP1

3.23e-06263228669633
Pubmed

Infection perturbs Bach2- and Bach1-dependent erythroid lineage 'choice' to cause anemia.

BACH2 BACH1

3.23e-06263230250186
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

3.23e-0626328791520
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

3.23e-0626328120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

3.23e-06263235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

3.23e-0626328307578
Pubmed

Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells.

BACH2 BACH1

3.23e-06263216631738
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

3.23e-06263210504303
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

3.23e-0626327744963
Pubmed

Crystal structure of the Bach1 BTB domain and its regulation of homodimerization.

BACH2 BACH1

3.23e-06263219170764
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

3.23e-06263226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

3.23e-06263218006876
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

3.23e-06263224833718
Pubmed

Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.

GPNMB RYR1

3.23e-06263221933672
Pubmed

Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues.

FBLN2 FBN1

3.23e-0626328702639
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

3.23e-06263224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

3.23e-06263220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

3.23e-06263225524144
Pubmed

The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo.

FBLN1 FBLN2

3.23e-0626328737292
Pubmed

The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis.

BACH2 BACH1

3.23e-06263227387751
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

3.23e-06263223133647
Pubmed

Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases.

FBLN1 FBLN2

3.23e-0626328841408
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

3.23e-06263216407178
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

3.23e-0626321852206
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

3.23e-06263210359653
Pubmed

Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells.

FBLN1 FBLN2

3.23e-06263219609566
Pubmed

Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice.

LYST LDLR

3.23e-06263215175354
Pubmed

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.

SPOPL SPOP

3.23e-06263216651542
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DNAJA3 FAT1 TUT4 FBN2 BACH2 SCAPER BIRC2 MACF1 SPOP TADA2A LDLR

4.72e-061116631131753913
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

DNAJA3 VPS18 AKAP9 GTF3C1 PRKAA2 BUB1 SCAPER BIRC2 LYST BTRC

5.22e-06910631036736316
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

FBLN1 FBLN2 FBN1 PSAP LTBP1 LDLR

5.98e-0624863624006456
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

FBLN1 FBLN2 FBN1 PSAP LTBP1

7.03e-0614663527068509
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

RIF1 FBN1 FBN2 NFXL1

8.67e-067163433541421
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

9.68e-06363210825173
Pubmed

Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.

PSAP RYR1

9.68e-06363227655403
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1B ANK2

9.68e-06363224394417
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

9.68e-06363230201140
Pubmed

Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.

ANK2 OBSCN

9.68e-06363212527750
Pubmed

A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors.

BACH2 BACH1

9.68e-06363228273455
Pubmed

The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.

BACH2 BACH1

9.68e-06363225344725
Pubmed

Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors.

HTR1F HTR2A

9.68e-06363215190056
Pubmed

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.

PSAP PAK2

9.68e-06363215047825
Pubmed

Association analysis of TPH2, 5-HT2A, and 5-HT6 with executive function in a young Chinese Han population.

HTR1F HTR2A

9.68e-06363221457069
Pubmed

Glucocorticoids down-regulate the extracellular matrix proteins fibronectin, fibulin-1 and fibulin-2 in bone marrow stroma.

FBLN1 FBLN2

9.68e-06363211737251
Pubmed

A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants.

FBN1 LYST

9.68e-0636328780155
Pubmed

Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo.

PRKAA2 LDLR

9.68e-06363220124121
Pubmed

The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study.

FBLN1 FBN1

9.68e-0636327534784
Pubmed

LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

FBN1 LTBP1

9.68e-06363217293099
Pubmed

Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.

ANK2 OBSCN

9.68e-06363218782775
Pubmed

Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors.

FBN1 LYST

9.68e-0636328166647
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

9.68e-06363220855508
Pubmed

c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.

DNAJA3 BIRC2 LDLR

1.12e-052463323085658
Pubmed

Functional proteomics mapping of a human signaling pathway.

DNAJA3 FBLN1 KANK1 FBN2 PSAP PEX19 MACF1 GPNMB

1.13e-0559163815231748
Pubmed

Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations.

FBLN1 FBLN2

1.93e-0546329676579
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

1.93e-05463225406291
Pubmed

Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2.

BACH2 BACH1

1.93e-05463221444915
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

1.93e-05463220729550
Pubmed

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

PRKAA2 LDLR

1.93e-05463221459323
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2

1.93e-05463225034023
Pubmed

Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice.

FBLN1 FBLN2

1.93e-05463226711913
Pubmed

A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.

BACH2 BACH1

1.93e-05463210669750
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

1.93e-05463216835936
Pubmed

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.

PRKAA2 FNIP1

1.93e-05463237079666
Pubmed

Association study of seven polymorphisms in four serotonin receptor genes on suicide victims.

HTR1F HTR2A

1.93e-05463216856120
Pubmed

Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations.

LYST LDLR

1.93e-05463212171798
Pubmed

Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.

FBLN2 FBN1

1.93e-05463215610515
Pubmed

Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins.

FBLN1 FBLN2

1.93e-05463210022829
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

FBN1 FBN2 LTBP1

2.22e-053063332882513
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

KMT2C USP45 PSAP SPOPL PIK3CD DIPK1A OBSCN NFXL1 MACF1 LDLR

2.37e-051084631011544199
Pubmed

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

FBN1 FBN2 LTBP1

2.46e-053163325762570
Pubmed

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?

HTR2A PIK3CD PRKAA2 TADA2A LDLR

2.64e-0519263520602615
Pubmed

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.

ZDHHC21 VPS18 HTR2A BACH2 BACH1

2.70e-0519363522589738
Pubmed

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

FBN1 FBN2

3.22e-05563226601954
Pubmed

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.

IL10RB LDLR

3.22e-05563230291029
Pubmed

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.

FBN1 FBN2

3.22e-05563212590922
Pubmed

Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.

SPOPL SPOP

3.22e-05563222632832
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2

3.22e-05563217255108
Pubmed

A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.

FBLN1 FBLN2

3.22e-05563211290292
InteractionMFAP5 interactions

FBLN1 FBN1 FBN2 KIAA0232 LDLR

5.44e-0752625int:MFAP5
InteractionNTN5 interactions

FBN1 FBN2 LTBP1 LDLR

8.24e-0724624int:NTN5
InteractionZFP41 interactions

FBLN1 FBN1 FBN2 LTBP1 LDLR

8.66e-0757625int:ZFP41
InteractionELN interactions

FBLN1 FBLN2 FBN1 FBN2

1.82e-0629624int:ELN
InteractionZNF408 interactions

FBLN2 FBN1 FBN2 KIAA0232 LTBP1 LDLR

5.52e-06145626int:ZNF408
InteractionFNIP1 interactions

AKAP9 PRKAA2 FNIP1 BTRC

7.55e-0641624int:FNIP1
InteractionLTBP1 interactions

FBLN2 FBN1 FBN2 PSAP LTBP1

9.36e-0692625int:LTBP1
InteractionSFRP4 interactions

FBLN1 FBN2 BUB1 BTRC

1.55e-0549624int:SFRP4
InteractionFBN1 interactions

FBLN2 FBN1 FBN2 LTBP1

1.82e-0551624int:FBN1
InteractionLYPD4 interactions

VPS18 FAT1 FBN2 DIPK1A OBSCN

3.82e-05123625int:LYPD4
InteractionFBLN2 interactions

FBLN1 FBLN2 FBN1 LTBP1

5.07e-0566624int:FBLN2
InteractionBRINP3 interactions

FAT1 KIAA0232 BUB1

6.08e-0525623int:BRINP3
InteractionDUSP16 interactions

VPS18 TUT4 COG6 KIAA0232 BUB1 FIGNL1

8.80e-05237626int:DUSP16
InteractionTAFA3 interactions

FBLN1 FBN2 BIRC2 LDLR

9.77e-0578624int:TAFA3
InteractionCREB5 interactions

FBLN1 SPOPL BACH2 BACH1 SPOP

1.49e-04164625int:CREB5
GeneFamilyFibulins

FBLN1 FBLN2

1.53e-048432556
GeneFamilyBasic leucine zipper proteins|BTB domain containing

SPOPL BACH2 BACH1 SPOP

2.85e-04134434861
GeneFamily5-hydroxytryptamine receptors, G protein-coupled

HTR1F HTR2A

4.24e-0413432170
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

RIF1 FAT1 KANK1 TUT4 AKAP9 KIAA0232 BACH1 BIRC2 SPOP

4.12e-08300639M8702
CoexpressionCUI_DEVELOPING_HEART_TRABECULAR_ATRIAL_CARDIOMYOCYTE

FAT1 FBN2 PSAP AKAP9 LUC7L3 MACF1 LTBP1

2.47e-07179637M39308
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

KMT2C RIF1 TUT4 GTF3C1 PIK3CD MACF1 PRR14L

2.56e-07180637M8239
CoexpressionGSE20366_EX_VIVO_VS_DEC205_CONVERSION_NAIVE_CD4_TCELL_UP

KIAA0232 BUB1 TADA2A FIGNL1 LDLR RYR1

8.66e-06200636M4327
CoexpressionDI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC

FBLN2 FBN2 LTBP1

3.71e-0527633M47994
CoexpressionBOQUEST_STEM_CELL_UP

FBLN1 FAT1 FBN1 ANK2 DIPK1A GPNMB

3.89e-05261636M1834
CoexpressionNABA_ECM_GLYCOPROTEINS

FBLN1 FBLN2 FBN1 FBN2 LTBP1

9.73e-05191635MM17059
CoexpressionZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN

DIPK1A BACH2 TESPA1

1.05e-0438633M1751
CoexpressionNABA_ECM_GLYCOPROTEINS

FBLN1 FBLN2 FBN1 FBN2 LTBP1

1.10e-04196635M3008
CoexpressionGSE27786_LIN_NEG_VS_BCELL_DN

TUT4 DIPK1A SCAPER SPOP LYST

1.21e-04200635M4768
CoexpressionKAECH_NAIVE_VS_MEMORY_CD8_TCELL_UP

PSAP AKAP9 GTF3C1 BIRC2 LDLR

1.21e-04200635M3020
CoexpressionTRAYNOR_RETT_SYNDROM_UP

FBLN1 FNIP1 LTBP1

1.23e-0440633M2712
CoexpressionZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN

DIPK1A BACH2 TESPA1

1.42e-0442633MM733
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

FAT1 KANK1 LUC7L3 BACH1 MACF1

1.59e-04212635M39221
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

ZDHHC21 RIF1 CFAP54 TUT4 AKAP9 ANK2 LUC7L3 ARVCF PIK3CD ICE2 BUB1 MACF1 CTIF FIGNL1 XKR5

2.76e-0710606215facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500

ZDHHC21 RIF1 CFAP54 TUT4 AKAP9 ANK2 LUC7L3 ARVCF PIK3CD ICE2 BUB1 MACF1 CTIF FIGNL1 XKR5

9.89e-0614146215facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

BDP1 USP45 TUT4 AKAP9 COG6 ICE2 BIRC2 FNIP1 MACF1 PRR14L LDLR

1.41e-057806211Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C RIF1 PSAP AKAP9 SCAPER FNIP1 MACF1 LDLR

3.40e-101956383e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C RIF1 PSAP AKAP9 SCAPER FNIP1 MACF1 LDLR

3.40e-101956387796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 AKAP9 ANK2 GTF3C1 MACF1 LTBP1 NRIP3

4.16e-102006389b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN1 FBLN2 FBN1 ANK2 WSCD2 LTBP1

1.27e-071656364e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCell356C-Fibroblasts-Fibroblast-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 FBLN2 FBN1 HTR2A LTBP1 CPS1

1.99e-07178636a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell356C-Fibroblasts-Fibroblast-E|356C / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 FBLN2 FBN1 HTR2A LTBP1 CPS1

1.99e-07178636371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

FBLN1 KANK1 FBN1 FBN2 ANK2 WSCD2

2.49e-07185636427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 HTR2A ANK2 LTBP1

3.10e-07192636b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 KANK1 FBLN2 FBN1 LTBP1 GPNMB

3.20e-07193636e27885a9e1a2a3e165c5366d4cfcda05c5454483
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 HTR2A ANK2 LTBP1

3.40e-0719563651db90e7611f7d69980878c046505ff34212079b
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FAT1 FBN1 ANK2 MROH2A LTBP1

3.50e-071966366bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FAT1 FBN1 ANK2 MROH2A LTBP1

3.50e-07196636c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBLN1 FBLN2 FBN1 ANK2 MACF1 LTBP1

3.50e-071966367d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.60e-07197636fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

FBLN1 FBLN2 FBN1 ANK2 BACH2 LTBP1

3.71e-0719863626e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBLN1 FBLN2 FBN1 ANK2 MACF1 LTBP1

3.71e-071986368f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCelldistal-3-mesenchymal-Adventitial_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FBLN1 FBLN2 FBN1 HTR2A ANK2 LTBP1

3.82e-07199636547a7c30abc730af2670aee00c7a6af60426c9ac
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.82e-07199636e1849505b92820a219c5a2c35492bdd55579fb48
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.94e-07200636b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.94e-0720063650ca6550998e461ef26dd670351060bd940765a8
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.94e-072006363bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN1 FBLN2 FBN1 ANK2 LTBP1 GPNMB

3.94e-07200636b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.94e-0720063644a68bacdb3d5bf563bd35952176995850933a81
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 AKAP9 ANK2 MACF1 LTBP1

3.94e-07200636a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBLN1 FBN1 ANK2 MACF1 LTBP1 NRIP3

3.94e-07200636dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellTracheal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN1 FBLN2 FBN1 ANK2 LTBP1 GPNMB

3.94e-072006367ba292c30d915e66ebc8026fa76492cedf64700e
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN1 FBLN2 FBN1 ANK2 BACH2 LTBP1

3.94e-0720063674e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

TUT4 LUC7L3 SCAPER OBSCN MACF1

2.39e-06151635999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell367C-Fibroblasts-Fibroblast-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 FBLN2 FBN1 ANK2 LTBP1

2.64e-06154635dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell367C-Fibroblasts-Fibroblast-D|367C / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 FBLN2 FBN1 ANK2 LTBP1

2.64e-061546354bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN1 FBLN2 FBN1 ANK2 LTBP1

3.92e-06167635fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

4.53e-06172635e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZDHHC21 BDP1 SPOPL BACH1 LYST

4.65e-06173635d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 FBLN2 FBN1 HTR2A GPNMB

4.65e-0617363511e95a60b5f6f07f27154a23203bac431e7528c6
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 FBLN2 FBN1 ANK2 LTBP1

5.06e-061766352e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

FBLN1 FBLN2 FBN1 ANK2 LTBP1

5.06e-06176635f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

5.96e-06182635d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.12e-0618363563294d66e3ccf152ffe5d1237106764c14390b62
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.12e-061836357e5c467fd1b156b928f1611a12ab4affb9f714b7
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FBN2 MROH2A OBSCN CPS1

6.28e-061846352cbed6462fea2622871bb7e49b0df3d984239281
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 HTR2A ANK2

6.28e-061846354a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 ANK2 WSCD2 GPNMB

6.28e-06184635fea4fe648e9749177d0783443dc26a7df5807883
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

FBLN1 FBLN2 FBN1 BACH2 LTBP1

6.28e-061846352b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FBN2 MROH2A OBSCN CPS1

6.28e-06184635ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FBN2 MROH2A OBSCN CPS1

6.28e-061846352b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 ANK2 WSCD2 GPNMB

6.28e-0618463596a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 ANK2 WSCD2 GPNMB

6.28e-06184635780eb72da43527f0c72effac3423ec7384f05f20
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN2 ANK2 PRKAA2 OBSCN LTBP1

6.45e-06185635549eeb521c3985bff396ea0f202db21822efa51f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 CFAP54 FBN2 WSCD2 CTIF

6.45e-0618563534fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 CFAP54 FBN2 WSCD2 CTIF

6.45e-061856358816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBN1 ARVCF WSCD2 TADA2A

6.62e-06186635827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCellfacs-Trachea-nan-24m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.80e-0618763571385068e3fd0bfa7822ae176113a49460c8636b
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.80e-06187635f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.80e-061876351669df899b1759c338ffce196fe009840123cfcd
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 FBN2 GPNMB

6.80e-061876354e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 FBN2 GPNMB

6.80e-06187635d36e7fc6125e7a4310499365022d38f34b757a73
ToppCellfacs-Trachea-nan-24m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.80e-06187635b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 FBN2 GPNMB

6.80e-06187635827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellfacs-Trachea-nan-24m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

6.80e-06187635e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

FBLN1 FBLN2 FBN1 ANK2 LTBP1

6.97e-06188635706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

KANK1 FBN2 ANK2 PRKAA2 OBSCN

7.16e-061896355e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.16e-06189635d531399749409d614adca13d181830c6e3287508
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.16e-06189635dde037322c8caec0c04c5be1c1b59a167824ad9f
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.53e-061916350fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 FBN2 LTBP1

7.72e-061926358937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.72e-061926357b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.72e-06192635fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 FBN2 LTBP1

7.72e-06192635e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBLN1 FBN1 ANK2 LTBP1 NRIP3

7.72e-06192635df1545670370fb1010c567cd059c2783eab315f7
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBLN1 FBN1 ANK2 MACF1 LTBP1

7.72e-0619263599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 FBN2 LTBP1

7.72e-06192635ac1477433704573f95111eee6263b93668d2845e
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.72e-0619263532acd89617934016cd135d2cc797e8e79ae1b37f
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.72e-061926357a2e79490e4f7058bb76b46c45b5df9f729e3146
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.72e-06192635e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.72e-06192635c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell|Adult / Lineage, Cell type, age group and donor

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.72e-06192635d21f0f577156f17c899b08871046a26b88aea011
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.72e-06192635a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellfacs-Trachea-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.72e-06192635e8af6ad1ae99cae13a82d0d8d7f38af9b777f0ba
ToppCellfacs-MAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.92e-06193635733f557bdc80293b40ccdf560f1675793df932d6
ToppCellfacs-MAT-Fat-24m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.92e-06193635eb3c46b6fb06dc8708dc3032189b47ed93ee2357
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AKAP9 LUC7L3 SCAPER MACF1 USP9Y

7.92e-061936359337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBLN1 FBLN2 FBN1 ANK2 LTBP1

7.92e-061936359ab47b360bee1d4f1092c2269e58acebe9584021
ToppCellfacs-MAT-Fat-24m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

7.92e-06193635b45cd02081f97904eaea2d013e1fa980505d060b
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BDP1 AKAP9 BACH1 PAK2 MACF1

8.12e-06194635e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

8.12e-06194635c9e589fe7df6a9b377654581a2aebb607cbb03b9
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.12e-0619463535b30bc954750e939f81a9a7498b8bc2ce69a299
ToppCellASK428-Mesenchymal|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.33e-061956352b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.33e-06195635f54bc4454270ff06e85596f98199372b50d0179f
ToppCellIPF-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.33e-061956359c32756edb54f0c211185d9a98073fe01fd1526a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.33e-061956351236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

8.33e-06195635773728703bc8969bff0e1de58fe3e1631add0a0a
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 FBLN2 FBN1 ANK2 GPNMB

8.33e-06195635fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCellASK428-Mesenchymal-Fibroblast|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.33e-06195635c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCellfacs-Heart-LA|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 FBLN2 FBN1 LTBP1 GPNMB

8.54e-061966358a84aeb1a565dd3e2a690fcaf1ab804f5e253545
ToppCellIPF-Stromal-Fibroblast|IPF / Disease state, Lineage and Cell class

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.54e-06196635f7ae604ba32b322d86d68b2b54892e7c6ab06c49
ToppCellIPF-Stromal-Myofibroblast|IPF / Disease state, Lineage and Cell class

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.54e-061966352d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell(5)_Fibroblasts-(5)_Fibroblast-E|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

FBLN1 FBLN2 FBN1 PSAP GPNMB

8.75e-061976359b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN1 FBLN2 FBN1 ANK2 GPNMB

8.75e-06197635ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.75e-0619763571786e9432e2d649f5d86f639abb25e7102deb67
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN1 FBLN2 FBN1 ANK2 LTBP1

8.75e-06197635c747c496ac090309b7f8a3e9d840928f12c83f2f
ComputationalMetal / Ca ion binding.

FBLN1 FAT1 FBLN2 FBN1 FBN2 LTBP1 LDLR

5.03e-07133407MODULE_324
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

RIF1 FAT1 LUC7L3 MACF1

3.35e-0550404GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
ComputationalDRG (dorsal root ganglia) genes.

FBLN1 FAT1 FBLN2 FBN1 BIRC2 LTBP1 GPNMB LDLR

6.95e-05384408MODULE_2
ComputationalOvary genes.

FBLN1 FAT1 FBN1 BIRC2 LTBP1 GPNMB LDLR

3.66e-04368407MODULE_1
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

BDP1 AKAP9 MACF1

7.81e-0449403GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

KMT2C AKAP9 LUC7L3

7.81e-0449403GAVISH_3CA_MALIGNANT_METAPROGRAM_41_UNASSIGNED
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

BDP1 RIF1 MACF1

8.29e-0450403GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Drugsergolexole

FAT1 HTR1F HTR2A

4.36e-0612633CID000060262
Drug5182598; Up 200; 25uM; MCF7; HT_HG-U133A_EA

ARVCF PIK3CD KIAA0232 BACH1 LDLR TESPA1

1.30e-05187636868_UP
DrugPNU-0251126 [267429-19-6]; Down 200; 1uM; PC3; HT_HG-U133A

FBLN1 SCAPER PRR14L TADA2A TESPA1 BTRC

1.75e-051976363692_DN
DrugLidoflazine [3416-26-0]; Up 200; 8.2uM; PC3; HT_HG-U133A

TUT4 HTR2A BACH1 BUB1 GPNMB BTRC

1.75e-051976365804_UP
DrugSB 202190; Up 200; 1uM; MCF7; HT_HG-U133A

KANK1 HTR1F ARVCF BACH1 PRR14L TADA2A

1.80e-051986366909_UP
DrugDiphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; MCF7; HT_HG-U133A

FBN1 AKAP9 ANK2 PIK3CD CTIF TADA2A

1.86e-051996363640_UP
Drugtamibarotene

IL10RB RIF1 FAT1 FBN2 AKAP9 PIK3CD PAK2 MACF1 CTIF

3.65e-05596639ctd:C061133
DrugSDZ 205-557

FAT1 HTR1F HTR2A

3.92e-0524633CID000005191
Drug1-(1-naphthyl)piperazine

FAT1 HTR1F HTR2A

5.02e-0526633CID000001342
Drugergolines

FAT1 HTR1F HTR2A

5.63e-0527633CID003083577
DrugCP-132,484

HTR1F HTR2A

7.50e-055632CID000132564
DrugN-methyl-DL-aspartic acid

CACNA1B FAT1 HTR2A AKAP9 PIK3CD ICE2 BIRC2 LDLR RYR1

7.55e-05655639CID000004376
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT_HG-U133A

FAT1 PSAP MACF1 GPNMB LDLR

8.14e-051606356133_DN
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

ARVCF PIK3CD SCAPER CPS1 LYST

1.31e-041776354821_UP
DrugCP-690334-01 [459212-38-5]; Up 200; 10uM; MCF7; HT_HG-U133A

ARVCF PIK3CD CTIF LYST LDLR

1.65e-041866354380_UP
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

BUB1 SCAPER LTBP1 TADA2A BTRC

1.78e-041896355248_DN
DrugLoperamide hydrochloride [34552-83-5]; Up 200; 7.8uM; PC3; HT_HG-U133A

ARVCF BACH2 SCAPER LYST LDLR

1.78e-041896354672_UP
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; HL60; HT_HG-U133A

AKAP9 BUB1 CTIF NRIP3 LDLR

1.78e-041896351288_DN
Drugtridecyl-stigmatellin

HTR1F HTR2A SPOP

1.85e-0440633CID000448047
Drug3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A

FBLN1 ARVCF SCAPER TADA2A BTRC

1.91e-041926353382_DN
Drugestradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A

ARVCF PIK3CD SCAPER TADA2A BTRC

1.91e-041926355955_UP
DrugFluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; PC3; HT_HG-U133A

RIF1 FBN2 DIPK1A PRR14L GPNMB

1.96e-041936356691_DN
DrugMetanephrine hydrochloride DL [881-95-8]; Down 200; 17.2uM; HL60; HG-U133A

FBLN1 PIK3CD BUB1 PEX19 MACF1

1.96e-041936352015_DN
DrugMeropenem [96036-03-2]; Up 200; 10.4uM; PC3; HT_HG-U133A

FBN2 AKAP9 ARVCF BUB1 CTIF

2.01e-041946355824_UP
DrugQuercetine dihydrate [6151-25-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

AKAP9 DIPK1A PRKAA2 CTIF TADA2A

2.01e-041946354264_DN
DrugIdoxuridine [54-42-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ARVCF LTBP1 PRR14L LDLR BTRC

2.01e-041946351480_DN
DrugDoxazosin mesylate [77883-43-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A

RIF1 FBLN1 ARVCF PRKAA2 TADA2A

2.01e-041946353363_UP
DrugPNU-0251126 [267429-19-6]; Down 200; 10uM; PC3; HT_HG-U133A

FBLN1 BUB1 SCAPER PAK2 TADA2A

2.01e-041946353689_DN
DrugProcainamide hydrochloride [614-39-1]; Down 200; 14.8uM; PC3; HT_HG-U133A

FBLN1 DIPK1A BUB1 SCAPER LDLR

2.01e-041946354602_DN
DrugTinidazole [19387-91-8]; Down 200; 16.2uM; HL60; HT_HG-U133A

TUT4 AKAP9 BUB1 MACF1 LYST

2.06e-041956352568_DN
DrugNafcillin sodium salt monohydrate [7177-50-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A

TUT4 ARVCF PRR14L LDLR BTRC

2.06e-041956353323_DN
Drug(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; PC3; HT_HG-U133A

TUT4 ANK2 TADA2A GPNMB BTRC

2.06e-041956354016_UP
DrugCefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; HL60; HT_HG-U133A

FBLN1 CTIF TADA2A LYST LDLR

2.06e-041956356159_DN
DrugAC1L5AAF

HTR1F HTR2A

2.09e-048632CID000173615
DrugN3RdUMP

BDP1 GTF3C1

2.09e-048632CID006439282
Drugmedifoxamine

HTR1F HTR2A

2.09e-048632CID000036109
Drugavitriptan

HTR1F HTR2A

2.09e-048632CID000133081
Drugbenzylguanidine

RIF1 LYST

2.09e-048632CID000016644
Drug5-fluoro-alpha-methyltryptamine

HTR1F HTR2A

2.09e-048632CID000012834
DrugAmiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A

FBLN1 ARVCF SCAPER CTIF RYR1

2.11e-041966355253_UP
Drug5255229; Up 200; 13uM; MCF7; HT_HG-U133A_EA

FBLN1 PIK3CD BACH1 SCAPER TADA2A

2.11e-04196635833_UP
DrugPapaverine hydrochloride [61-25-6]; Up 200; 10.6uM; PC3; HT_HG-U133A

RIF1 HTR2A ANK2 LYST BTRC

2.11e-041966355769_UP
Drug6-mercaptopurine monohydrate; Down 200; 100uM; MCF7; HG-U133A

ANK2 ARVCF PIK3CD LDLR BTRC

2.11e-04196635334_DN
DrugHydrochlorothiazide [58-93-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A

FBLN1 FBN2 SCAPER CTIF LYST

2.11e-041966351487_UP
DrugD-cycloserine [68-41-7]; Up 200; 39.2uM; MCF7; HT_HG-U133A

FBLN1 PIK3CD BUB1 CTIF RYR1

2.11e-041966356782_UP
DrugAtractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT_HG-U133A

SCAPER CTIF TADA2A GPNMB BTRC

2.11e-041966353435_UP
DrugTrimipramine maleate salt [521-78-8]; Down 200; 9.8uM; MCF7; HT_HG-U133A

FBLN1 TUT4 SCAPER LYST BTRC

2.11e-041966353342_DN
DrugMetrizamide [31112-62-6]; Up 200; 5uM; PC3; HT_HG-U133A

AKAP9 ANK2 BACH1 GPNMB TESPA1

2.11e-041966354075_UP
DrugSulfadiazine [68-35-9]; Up 200; 16uM; PC3; HT_HG-U133A

FBN1 BUB1 PRR14L TADA2A LYST

2.11e-041966351810_UP
DrugMethylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; HL60; HT_HG-U133A

ANK2 PIK3CD BACH1 SCAPER CPS1

2.16e-041976352994_DN
DrugThiethylperazine malate [52239-63-1]; Down 200; 6uM; MCF7; HT_HG-U133A

LUC7L3 PEX19 LTBP1 PRR14L TADA2A

2.16e-041976356232_DN
Drugaspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A_EA

LUC7L3 LTBP1 PRR14L TADA2A LDLR

2.16e-041976351042_UP
DrugFinasteride [98319-26-7]; Up 200; 10.8uM; PC3; HT_HG-U133A

HTR2A ANK2 SCAPER CTIF NRIP3

2.16e-041976353744_UP
DrugNafcillin sodium salt monohydrate [7177-50-6]; Up 200; 8.8uM; PC3; HT_HG-U133A

RIF1 HTR2A AKAP9 ARVCF NRIP3

2.16e-041976353983_UP
DrugPropantheline bromide [50-34-0]; Down 200; 9uM; MCF7; HT_HG-U133A

ARVCF PIK3CD DIPK1A TADA2A LYST

2.21e-041986354798_DN
DrugPralidoxime chloride [51-15-0]; Down 200; 23.2uM; MCF7; HT_HG-U133A

TUT4 ARVCF TADA2A LYST BTRC

2.21e-041986355383_DN
DrugDeferoxamine mesylate [138-14-7]; Up 200; 6uM; MCF7; HT_HG-U133A

ARVCF BUB1 SCAPER CTIF CPS1

2.21e-041986353842_UP
DrugBetonicine [515-25-3]; Up 200; 25.2uM; PC3; HT_HG-U133A

RIF1 ARVCF CTIF TADA2A GPNMB

2.21e-041986354301_UP
DrugPronethalol hydrochloride [51-02-5]; Up 200; 15uM; MCF7; HT_HG-U133A

RIF1 FBLN1 ARVCF BUB1 SCAPER

2.21e-041986357322_UP
DrugDydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A

FBLN1 ARVCF BACH1 CTIF RYR1

2.21e-041986352811_UP
Drug5-aminosalicylic acid; Down 200; 100uM; MCF7; HG-U133A

BUB1 PEX19 PAK2 BIRC2 LDLR

2.21e-04198635124_DN
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; MCF7; HT_HG-U133A

FBN1 ANK2 BACH1 SCAPER RYR1

2.21e-041986354695_UP
Drugthioridazine hydrochloride; Down 200; 10uM; HL60; HT_HG-U133A

DNAJA3 KANK1 GTF3C1 CTIF CPS1

2.21e-041986356189_DN
DrugAlverine citrate salt [5560-59-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A

FBLN1 HTR1F CTIF USP9Y RYR1

2.21e-041986352273_UP
DrugCP-320650-01 [172079-28-6]; Up 200; 1uM; MCF7; HT_HG-U133A

FBLN1 FBN1 HTR2A BACH2 GPNMB

2.21e-041986353908_UP
DrugDihydroergotamine tartrate [5989-77-5]; Down 200; 3uM; MCF7; HT_HG-U133A

ARVCF SCAPER LTBP1 TADA2A LYST

2.26e-041996356840_DN
DrugKarakoline [39089-30-0]; Down 200; 10.6uM; PC3; HT_HG-U133A

RIF1 PIK3CD BUB1 TESPA1 BTRC

2.26e-041996353741_DN
DrugAlfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; HL60; HG-U133A

KANK1 PIK3CD BUB1 LDLR BTRC

2.26e-041996351586_DN
Drugtolbutamide; Down 200; 100uM; MCF7; HG-U133A

ARVCF PIK3CD BUB1 SCAPER LTBP1

2.26e-04199635142_DN
DrugChrysin [480-40-0]; Up 200; 15.8uM; MCF7; HT_HG-U133A

ARVCF BUB1 CPS1 USP9Y NRIP3

2.26e-041996355505_UP
Drug0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A

HTR1F CTIF PRR14L TADA2A LYST

2.26e-041996354334_UP
Drugchlorpromazine hydrochloride; Up 200; 1uM; HL60; HT_HG-U133A

BACH2 PRKAA2 CPS1 BTRC RYR1

2.26e-041996352677_UP
DrugIsocorydine (+) [475-67-2]; Down 200; 11.8uM; PC3; HT_HG-U133A

PRKAA2 BACH1 SCAPER TADA2A BTRC

2.31e-042006354505_DN
Drugcisapride

FAT1 HTR1F HTR2A RYR1

2.64e-04112634CID000002769
Druglactosyl lysosphingolipid

PSAP RYR1

2.68e-049632CID006439268
Drug2,5-dimethoxy-4-iodoamphetamine

HTR1F HTR2A BTRC RYR1

3.12e-04117634CID000001229
Drugcyproconazole

FBN2 PSAP AKAP9 LUC7L3 PRKAA2 LDLR

3.31e-04336636ctd:C093628
Drugseganserin

HTR1F HTR2A

3.34e-0410632CID000071767
DrugLY344864

HTR1F HTR2A

3.34e-0410632CID005311097
Drugfuniferine N-oxide

FBN1 FBN2 LTBP1

3.40e-0449633CID000191631
DiseaseColorectal Carcinoma

KMT2C VPS18 FAT1 FBLN2 FBN2 AKAP9 ANK2 BUB1 OBSCN GPNMB

2.23e-067026310C0009402
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

1.34e-053632DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

2.68e-054632DOID:0060249 (is_implicated_in)
Diseaseeosinophil count

AKAP9 ARVCF COG6 PIK3CD DIPK1A ICE2 KIAA0232 BACH2 MKRN2 PAK2 FNIP1 CPS1

6.31e-0514886312EFO_0004842
Diseaseosteoarthritis, knee, body mass index

WSCD2 LTBP1 CPS1

9.33e-0541633EFO_0004340, EFO_0004616
Diseasecolorectal cancer (is_implicated_in)

FAT1 PIK3CD BUB1 SPOP

1.33e-04121634DOID:9256 (is_implicated_in)
DiseaseColorectal Neoplasms

FAT1 FBLN2 FBN2 BUB1 GPNMB

3.17e-04277635C0009404
DiseaseMalignant neoplasm of breast

RIF1 AKAP9 ANK2 PRKAA2 OBSCN BIRC2 MACF1 CTIF GPNMB

4.39e-041074639C0006142
DiseaseRomano-Ward Syndrome

AKAP9 ANK2

5.28e-0416632C0035828
Diseasebehavior or behavioral disorder measurement, personality trait

FBLN1 WSCD2

6.71e-0418632EFO_0004365, EFO_0004782
Diseaseglomerulonephritis (biomarker_via_orthology)

FBN1 LTBP1

8.32e-0420632DOID:2921 (biomarker_via_orthology)
Diseaselymphocyte count

FBN1 ARVCF PIK3CD KIAA0232 BACH2 PRKAA2 PAK2 TADA2A CPS1 LYST

1.01e-0314646310EFO_0004587
DiseaseFEV/FEC ratio

FBLN1 KANK1 FBN1 ARVCF DIPK1A KIAA0232 BACH2 SCAPER LTBP1

1.14e-031228639EFO_0004713
DiseaseBrugada Syndrome (disorder)

AKAP9 ANK2

1.20e-0324632C1142166
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

MACF1 CPS1 LDLR

1.41e-03103633EFO_0008595, EFO_0020944
Diseasepeptide measurement

CACNA1B KANK1 SCAPER

1.66e-03109633EFO_0010520
DiseaseCholestasis

KANK1 ALDH8A1 NFXL1

1.70e-03110633C0008370
Diseasebasophil count, eosinophil count

COG6 BACH2 PAK2 FNIP1

1.77e-03241634EFO_0004842, EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
ISDFCQQMTDKCTTD

BACH1

721

O14867
QTVTVDFCQEMTDKC

BACH2

816

Q9BYV9
DFCQEMTDKCTTDEQ

BACH2

821

Q9BYV9
ECSKEQMLSCTQNID

BDP1

511

A6H8Y1
DLETQIECLMSDQEC

AKAP9

2326

Q99996
TVITDIKDESCCMTE

ALDH8A1

376

Q9H2A2
SVDNEMEDMIIQCCS

CFAP54

3026

Q96N23
KDTDNKSVENCVCIM

ARVCF

561

O00192
KQCTQATLDSCEENM

BUB1

631

O43683
VKEDAVLCCSMELQS

CTIF

516

O43310
VNVCDKCKISEEMSN

HTR1F

316

P30939
VCEKFECTESEVMNS

PRKAA2

296

P54646
ETVCLASTAMKTENC

BTRC

91

Q9Y297
TQNTVCSPVDVDEMC

GPNMB

436

Q14956
ITNIMAVICKESCNE

HTR2A

341

P28223
VMSECSLEKNERACI

CACNA1B

1426

Q00975
QASQDKVCSICMEVI

MKRN2

231

Q9H000
CFCMTDDKVDKTLEQ

ANK2

1346

Q01484
CSDVSACCEVESEVM

FAT1

4546

Q14517
MSKEQCCLSEEEIEQ

FIGNL1

581

Q6PIW4
QSGEDSKMLVCDTCD

KMT2C

396

Q8NEZ4
ENQVSIECDTTCKEM

NFXL1

816

Q6ZNB6
MADGVSCEDINECVT

FBLN2

711

P98095
SEANCKIMAQCEEEI

KIAA0232

1226

Q92628
AKMTCVDVNECDELN

LTBP1

1656

Q14766
VEMCDKSVSVEVSVC

KANK1

586

Q14678
SFAAQEKQMEVCEVC

LUC7L3

181

O95232
ACNQTAEMSCNKVEE

MACF1

2801

Q9UPN3
QELQQCDTDDDVAMC

OBSCN

5756

Q5VST9
TESKECRMVQEQCCH

FBLN1

56

P23142
TETCMDEAQIAAVCR

PAK2

336

Q13177
QHSVMCKICEQFEAE

PEX19

221

P40855
LESISEDVQAMSNCC

COG6

101

Q9Y2V7
VVRDADDNCVTVCNM

CPS1

636

P31327
DDNCVTVCNMENVDA

CPS1

641

P31327
MSCEVNECRKIESLE

ICE2

376

Q659A1
ASEDMKTCVDVNECD

FBN1

1271

P35555
ECQMISPSDCQEENA

FNIP1

646

Q8TF40
IFQDKCMNTTLTECD

IL10RB

61

Q08334
SSCESAKTVCEMEAV

LYST

2166

Q99698
SQDQTMCMDVDECER

FBN2

1926

P35556
KEFTVNIMDTCERCN

DNAJA3

226

Q96EY1
SCDQSTMKCTSEVIQ

DIPK1A

346

Q5T7M9
CESDQSVVECKEVLM

SCAPER

121

Q9BY12
LSCSEADENEMINCE

RYR1

4111

P21817
QSIACEMNELSCTNE

PRR14L

626

Q5THK1
CMEFSCDEVVSLIQK

MROH2A

1071

A6NES4
KSEEDDMILVSCQCA

NRIP3

101

Q9NQ35
QDVANQMCTKTKEEC

TADA2A

96

O75478
EESDTDEKCTICLSM

RNF165

286

Q6ZSG1
EENLCCEELSSKIMS

RIF1

726

Q5UIP0
QEERTCKVCMDKEVS

BIRC2

566

Q13490
TVMCEECANISTVKD

USP45

361

Q70EL2
KVMCEEALCSNLSVE

SPOPL

286

Q6IQ16
KVMCEDALCSNLSVE

SPOP

286

O43791
EEEDVQTAMACLASC

VPS18

766

Q9P253
LAEVCVEQCTFMDSK

PIK3CD

741

O00329
VEDEQVCCEALEVMT

USP9Y

1281

O00507
DVCQDCIQMVTDIQT

PSAP

196

P07602
ITDTTSIEKMSNCCE

ZDHHC21

206

Q8IVQ6
VFCCEEETQQRMSTV

TESPA1

361

A2RU30
QATNVSEAECDMECK

WSCD2

186

Q2TBF2
ESIQTDCSCREQMKQ

XKR5

666

Q6UX68
IMDQEKQEGVSTKCC

GTF3C1

641

Q12789
EQPVQCDEMDCTSQR

TUT4

761

Q5TAX3
CKDMSDEVGCVNVTL

LDLR

261

P01130