Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nicotinic acid receptor activity	HCAR2 HCAR3	2.69e-05	2	104	2	GO:0070553
GeneOntologyCellularComponent	preribosome, large subunit precursor	RPF1 NOC2L MRTO4	1.58e-04	21	106	3	GO:0030687
GeneOntologyCellularComponent	guanyl-nucleotide exchange factor complex	MON1A C9orf72 RIC1	2.37e-04	24	106	3	GO:0032045
Domain	Homeobox_metazoa	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	1.23e-05	90	106	6	IPR020479
Domain	Tscrpt_reg_Wos2-domain	MYB MYBL1	3.19e-05	2	106	2	IPR012642
Domain	EIF4A1/2	EIF4A1 EIF4A2	3.19e-05	2	106	2	IPR031258
Domain	HCAR2/3_rcpt	HCAR2 HCAR3	3.19e-05	2	106	2	IPR028017
Domain	LMSTEN	MYB MYBL1	3.19e-05	2	106	2	PF07988
Domain	Cmyb_C	MYB MYBL1	9.54e-05	3	106	2	PF09316
Domain	C-myb_C	MYB MYBL1	9.54e-05	3	106	2	IPR015395
Domain	-	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1 MYB MYBL1	2.10e-04	283	106	8	1.10.10.60
Domain	ANTENNAPEDIA	PDX1 HOXA2 HOXB2	3.30e-04	24	106	3	PS00032
Domain	Homeodomain-like	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1 MYB MYBL1	6.10e-04	332	106	8	IPR009057
Domain	HTH_motif	HLX HOXA2 HOXB2 NKX6-1	6.38e-04	69	106	4	IPR000047
Domain	Homeobox_CS	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	6.73e-04	186	106	6	IPR017970
Domain	-	EPHB6 CNTNAP1 F5 HERC2	7.90e-04	73	106	4	2.60.120.260
Domain	DHC_N1	DYNC1H1 DNAH11	8.74e-04	8	106	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC1H1 DNAH11	8.74e-04	8	106	2	IPR013594
Domain	HTH_MYB	MYB MYBL1	1.12e-03	9	106	2	PS51294
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN5	1.12e-03	9	106	2	IPR001605
Domain	Myb_dom	MYB MYBL1	1.12e-03	9	106	2	IPR017930
Domain	Anoctamin	ANO9 ANO8	1.39e-03	10	106	2	PF04547
Domain	Anoctamin	ANO9 ANO8	1.39e-03	10	106	2	IPR007632
Domain	SAM_2	EPHB6 SAMD9 WDSUB1	1.86e-03	43	106	3	PF07647
Domain	Galactose-bd-like	EPHB6 CNTNAP1 F5 HERC2	2.02e-03	94	106	4	IPR008979
Domain	Homeobox	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	2.18e-03	234	106	6	PF00046
Domain	HOMEOBOX_1	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	2.28e-03	236	106	6	PS00027
Domain	HOX	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	2.33e-03	237	106	6	SM00389
Domain	HOMEOBOX_2	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	2.43e-03	239	106	6	PS50071
Domain	Homeobox_dom	PDX1 HLX BSX HOXA2 HOXB2 NKX6-1	2.43e-03	239	106	6	IPR001356
Domain	Dynein_heavy_chain_D4_dom	DYNC1H1 DNAH11	2.78e-03	14	106	2	IPR024317
Domain	Dynein_HC_stalk	DYNC1H1 DNAH11	2.78e-03	14	106	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC1H1 DNAH11	2.78e-03	14	106	2	IPR013602
Domain	DHC_N2	DYNC1H1 DNAH11	2.78e-03	14	106	2	PF08393
Domain	MT	DYNC1H1 DNAH11	2.78e-03	14	106	2	PF12777
Domain	AAA_8	DYNC1H1 DNAH11	2.78e-03	14	106	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC1H1 DNAH11	2.78e-03	14	106	2	IPR011704
Domain	AAA_5	DYNC1H1 DNAH11	2.78e-03	14	106	2	PF07728
Domain	DHC_fam	DYNC1H1 DNAH11	3.19e-03	15	106	2	IPR026983
Domain	Dynein_heavy_dom	DYNC1H1 DNAH11	3.19e-03	15	106	2	IPR004273
Domain	Dynein_heavy	DYNC1H1 DNAH11	3.19e-03	15	106	2	PF03028
Pubmed	Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.	RAG1 HCAR2 HCAR3	1.20e-07	4	109	3	29514953
Pubmed	Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning.	HOXA2 HOXB2 NKX6-1	3.54e-06	10	109	3	23197710
Pubmed	β1 integrin is a crucial regulator of pancreatic β-cell expansion.	PDX1 ITGB1 NKX6-1	3.54e-06	10	109	3	23863477
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	L1CAM CNTNAP1 MR1 RXYLT1 COLGALT1 CTSA ITGB1 ELAC2 GPR107 CDC37 SULF2 PRCP TRIM28 TIMELESS GPAT4	5.29e-06	1201	109	15	35696571
Pubmed	Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.	HCAR2 HCAR3	9.73e-06	2	109	2	28186140
Pubmed	The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.	HCAR2 HCAR3	9.73e-06	2	109	2	30154797
Pubmed	Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors.	PDX1 NKX6-1	9.73e-06	2	109	2	27998294
Pubmed	The role of HCA2 (GPR109A) in regulating macrophage function.	HCAR2 HCAR3	9.73e-06	2	109	2	23882124
Pubmed	Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.	HCAR2 HCAR3	9.73e-06	2	109	2	36891315
Pubmed	Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.	HCAR2 HCAR3	9.73e-06	2	109	2	38007572
Pubmed	Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases.	MYB MYBL1	9.73e-06	2	109	2	36074655
Pubmed	Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.	HCAR2 HCAR3	9.73e-06	2	109	2	24691444
Pubmed	Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.	HCAR2 HCAR3	9.73e-06	2	109	2	31347703
Pubmed	Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.	HCAR2 HCAR3	9.73e-06	2	109	2	30659164
Pubmed	Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.	HCAR2 HCAR3	9.73e-06	2	109	2	19223991
Pubmed	Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.	EIF4A1 EIF4A2	9.73e-06	2	109	2	26614665
Pubmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.	HCAR2 HCAR3	9.73e-06	2	109	2	23967184
Pubmed	Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status.	EIF4A1 EIF4A2	9.73e-06	2	109	2	9015395
Pubmed	Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.	HCAR2 HCAR3	9.73e-06	2	109	2	26371038
Pubmed	Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.	HCAR2 HCAR3	9.73e-06	2	109	2	34653248
Pubmed	Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).	HCAR2 HCAR3	9.73e-06	2	109	2	19136666
Pubmed	G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.	HCAR2 HCAR3	9.73e-06	2	109	2	33488584
Pubmed	DNA binding and transactivation activity of A-myb, a c-myb-related gene.	MYB MYBL1	9.73e-06	2	109	2	7987850
Pubmed	Lactate-induced activation of HCA2 improves survival in mice with sepsis.	HCAR2 HCAR3	9.73e-06	2	109	2	30951370
Pubmed	Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.	MYB MYBL1	9.73e-06	2	109	2	31563982
Pubmed	Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.	HCAR2 HCAR3	9.73e-06	2	109	2	31858105
Pubmed	Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.	HCAR2 HCAR3	9.73e-06	2	109	2	32068460
Pubmed	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	HCAR2 HCAR3	9.73e-06	2	109	2	30657794
Pubmed	Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.	HCAR2 HCAR3	9.73e-06	2	109	2	34092246
Pubmed	Molecular identification of high and low affinity receptors for nicotinic acid.	HCAR2 HCAR3	9.73e-06	2	109	2	12522134
Pubmed	G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.	HCAR2 HCAR3	9.73e-06	2	109	2	30271409
Pubmed	Expression of mouse c-myb during embryonic development.	MYB MYBL1	9.73e-06	2	109	2	8570177
Pubmed	Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.	HOXA2 HOXB2	9.73e-06	2	109	2	28052248
Pubmed	Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.	HCAR2 HCAR3	9.73e-06	2	109	2	30596513
Pubmed	The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.	HCAR2 HCAR3	9.73e-06	2	109	2	35320002
Pubmed	GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.	HCAR2 HCAR3	9.73e-06	2	109	2	16322797
Pubmed	Nicotinic acid receptor agonists.	HCAR2 HCAR3	9.73e-06	2	109	2	18983141
Pubmed	Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.	HCAR2 HCAR3	9.73e-06	2	109	2	31366236
Pubmed	TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells.	RAG1 TRIM28	9.73e-06	2	109	2	23169648
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	9.73e-06	2	109	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	9.73e-06	2	109	2	11689483
Pubmed	GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.	HCAR2 HCAR3	9.73e-06	2	109	2	35489706
Pubmed	A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.	MYB MYBL1	9.73e-06	2	109	2	31595312
Pubmed	Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.	HCAR2 HCAR3	9.73e-06	2	109	2	19561068
Pubmed	Detecting MYB and MYBL1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted RNA-sequencing.	MYB MYBL1	9.73e-06	2	109	2	31028361
Pubmed	The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.	HCAR2 HCAR3	9.73e-06	2	109	2	24371223
Pubmed	High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.	HCAR2 HCAR3	9.73e-06	2	109	2	21774590
Pubmed	Homeobox gene product Nkx 6.1 immunoreactivity in nuclei of endocrine cells of rat and mouse stomach.	PDX1 NKX6-1	9.73e-06	2	109	2	9603782
Pubmed	GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.	HCAR2 HCAR3	9.73e-06	2	109	2	36208084
Pubmed	The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.	HCAR2 HCAR3	9.73e-06	2	109	2	26656756
Pubmed	Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.	HCAR2 HCAR3	9.73e-06	2	109	2	37597514
Pubmed	The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.	HCAR2 HCAR3	9.73e-06	2	109	2	33924461
Pubmed	Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.	HCAR2 HCAR3	9.73e-06	2	109	2	33977048
Pubmed	A cellular response linking eIF4AI activity to eIF4AII transcription.	EIF4A1 EIF4A2	9.73e-06	2	109	2	22589333
Pubmed	PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.	HCAR2 HCAR3	9.73e-06	2	109	2	11745392
Pubmed	Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.	HCAR2 HCAR3	9.73e-06	2	109	2	25622782
Pubmed	MYB and MYBL1 in adenoid cystic carcinoma: diversity in the mode of genomic rearrangement and transcripts.	MYB MYBL1	9.73e-06	2	109	2	29410490
Pubmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.	HCAR2 HCAR3	9.73e-06	2	109	2	33420329
Pubmed	NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming.	PDX1 NKX6-1	9.73e-06	2	109	2	21108535
Pubmed	Molecular identification of nicotinic acid receptor.	HCAR2 HCAR3	9.73e-06	2	109	2	12646212
Pubmed	PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.	HCAR2 HCAR3	9.73e-06	2	109	2	12563315
Pubmed	Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation.	EIF4A1 EIF4A2	9.73e-06	2	109	2	24466343
Pubmed	Adenoid cystic carcinoma of the Bartholin's gland is underpinned by MYB- and MYBL1- rearrangements.	MYB MYBL1	9.73e-06	2	109	2	38368814
Pubmed	Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.	HCAR2 HCAR3	9.73e-06	2	109	2	30625381
Pubmed	Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.	HCAR2 HCAR3	9.73e-06	2	109	2	30085883
Pubmed	Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.	HCAR2 HCAR3	9.73e-06	2	109	2	21655214
Pubmed	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.	HCAR2 HCAR3	9.73e-06	2	109	2	15929991
Pubmed	Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.	HCAR2 HCAR3	9.73e-06	2	109	2	36991440
Pubmed	Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.	HCAR2 HCAR3	9.73e-06	2	109	2	25320346
Pubmed	The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed.	EIF4A1 EIF4A2	9.73e-06	2	109	2	3046931
Pubmed	Islet transplantation into brown adipose tissue can delay immune rejection.	PDX1 NKX6-1	9.73e-06	2	109	2	35015736
Pubmed	Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.	HCAR2 HCAR3	9.73e-06	2	109	2	21441844
Pubmed	BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.	HCAR2 HCAR3	9.73e-06	2	109	2	31914599
Pubmed	Arrest of spermatogenesis and defective breast development in mice lacking A-myb.	MYB MYBL1	9.73e-06	2	109	2	9109487
Pubmed	Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.	HCAR2 HCAR3	9.73e-06	2	109	2	20655299
Pubmed	Evidence for constitutive dimerization of niacin receptor subtypes.	HCAR2 HCAR3	9.73e-06	2	109	2	20380810
Pubmed	GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.	HCAR2 HCAR3	9.73e-06	2	109	2	26116596
Pubmed	Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.	HCAR2 HCAR3	9.73e-06	2	109	2	35649469
Pubmed	GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.	HCAR2 HCAR3	9.73e-06	2	109	2	37595951
Pubmed	The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate.	HCAR2 HCAR3	9.73e-06	2	109	2	26936786
Pubmed	Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.	HCAR2 HCAR3	9.73e-06	2	109	2	34084164
Pubmed	Evolution of the regulators of G-protein signaling multigene family in mouse and human.	RAG1 RGS11 MYB MYBL1	2.04e-05	51	109	4	11829488
Pubmed	Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.	CPA5 PDX1 NKX6-1	2.36e-05	18	109	3	12921743
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	L1CAM CNTNAP1 COLGALT1 CTSA ITGB1 CDC37 PRCP TRIM28 EIF4A1 RNASET2	2.40e-05	613	109	10	22268729
Pubmed	Beta-cell β1 integrin deficiency affects in utero development of islet growth and vascularization.	PDX1 ITGB1 NKX6-1	2.80e-05	19	109	3	32060653
Pubmed	Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption.	DYNC1H1 DNAH11	2.91e-05	3	109	2	22887640
Pubmed	Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.	HCAR2 HCAR3	2.91e-05	3	109	2	23579073
Pubmed	Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose.	HCAR2 HCAR3	2.91e-05	3	109	2	37215085
Pubmed	Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.	HCAR2 HCAR3	2.91e-05	3	109	2	20033346
Pubmed	Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions.	VPS8 ITGB1	2.91e-05	3	109	2	29476049
Pubmed	International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).	HCAR2 HCAR3	2.91e-05	3	109	2	21454438
Pubmed	Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity.	HCAR2 HCAR3	2.91e-05	3	109	2	34919284
Pubmed	The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.	HCAR2 HCAR3	2.91e-05	3	109	2	24845831
Pubmed	The myb gene family in cell growth, differentiation and apoptosis.	MYB MYBL1	2.91e-05	3	109	2	10378697
Pubmed	The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4+ T Cells Upon Inflammation.	RAG1 CCR9	2.91e-05	3	109	2	33864900
Pubmed	Oral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model.	HCAR2 HCAR3	2.91e-05	3	109	2	35189149
Pubmed	The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.	HCAR2 HCAR3	2.91e-05	3	109	2	33597149
Pubmed	The transcription factor XBP-1 is essential for the development and survival of dendritic cells.	RAG1 CEP120	2.91e-05	3	109	2	17875675
Pubmed	Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.	PDX1 NKX6-1	2.91e-05	3	109	2	28835709
Pubmed	Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.	HCAR2 HCAR3	2.91e-05	3	109	2	17008386
Cytoband	17q21.32	COPZ2 KAT7 HOXB2	2.22e-04	49	109	3	17q21.32
GeneFamily	Hydroxy-carboxylic acid receptors	HCAR2 HCAR3	5.64e-05	3	79	2	200
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTBN5	3.90e-04	7	79	2	1113
GeneFamily	Anoctamins	ANO9 ANO8	8.29e-04	10	79	2	865
GeneFamily	Dynein regulatory complex	DRC7 TCTE1	1.01e-03	11	79	2	981
GeneFamily	HOXL subclass homeoboxes	PDX1 HOXA2 HOXB2	1.52e-03	52	79	3	518
GeneFamily	Olfactory receptors, family 4	OR4F4 OR4F5 OR4K1 OR4F17	2.46e-03	129	79	4	151
GeneFamily	NKL subclass homeoboxes and pseudogenes	HLX BSX NKX6-1	3.15e-03	67	79	3	519
GeneFamily	Carboxypeptidases	CPA5 PRCP	3.75e-03	21	79	2	1321
CoexpressionAtlas	alpha beta T cells, T.DPsm.Th, 4+ 8+ TCR-/lo FSClo, Thymus, avg-3	EPHB6 RAG1 CCR9 MR1 MYB	2.82e-05	73	103	5	GSM399400_100
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 ANO9 HCAR2 RUBCNL GREB1 MYB DNAH11	2.55e-07	175	109	7	9a96794df049d8228fea57c1584c160191d36b56
Disease	Arthrogryposis	L1CAM VPS8 DYNC1H1	5.25e-05	21	103	3	C0003886
Disease	visceral heterotaxy (implicated_via_orthology)	CEP290 DNAAF3 DNAH11	2.94e-04	37	103	3	DOID:0050545 (implicated_via_orthology)
Disease	Kartagener syndrome (implicated_via_orthology)	DNAAF3 DNAH11	1.07e-03	14	103	2	DOID:0050144 (implicated_via_orthology)
Disease	arterial stiffness measurement	DAB2IP RIC1 SEC14L5	1.47e-03	64	103	3	EFO_0004517
Disease	hydrocephalus (implicated_via_orthology)	L1CAM ITGB1	1.99e-03	19	103	2	DOID:10908 (implicated_via_orthology)
Disease	haptoglobin measurement	PKD1L3 DHODH	2.43e-03	21	103	2	EFO_0004640
Disease	lung non-small cell carcinoma (is_marker_for)	DAB2IP L1CAM KDM3B ITGB1	2.96e-03	169	103	4	DOID:3908 (is_marker_for)
Disease	cardiac troponin I measurement	GRID1 ELAC2 DNAAF3 GREB1	3.42e-03	176	103	4	EFO_0010071
Disease	apolipoprotein L1 measurement	PKD1L3 DHODH	3.44e-03	25	103	2	EFO_0021854

Protein segments in the cluster

Peptide	Gene	Start	Entry
KAKQHMWRAIRTAFK	ABCA5	1466	Q8WWZ7
MRWHRKDKRAKAEAA	AMER2	201	Q8N7J2
WLQIDLMKKHRIRAV	CNTNAP1	71	P78357
LNKRDMKKRTALHWA	ANKRD30B	66	Q9BXX2
HMLRKNVEKRWLLEN	COPZ2	136	Q9P299
REFSLQMLWNRLHKE	CFAP46	2356	Q8IYW2
RDRHWHQLMKAIGVK	DNAH11	1406	Q96DT5
TWFQNRRMKHKKQLR	BSX	156	Q3C1V8
TRQEWVRLHDKMKVD	CCDC144CP	756	Q8IYA2
WLKDQRKAMHLKCAR	ADCY10	941	Q96PN6
LEVKYQRLREKMWHG	ANO9	736	A1A5B4
LKRVLRSLQAHKMAW	BPTF	2936	Q12830
VHEQRILNRLMKSWV	ANO8	211	Q9HCE9
RWQATLDKHLRKKMN	RAG1	831	P15918
QLDIRLMRHKAVWIN	RUBCNL	41	Q9H714
KKINHAWDLVLMQAR	RGS11	151	O94810
KWDLCRHMIRFLKAI	RIC1	971	Q4ADV7
KRRNDVFKIHWLMAA	GPR107	286	Q5VW38
WKLLMIIHDRREFAK	ITGB1	751	P05556
MAHRLQIRLLTWDVK	HDHD3	1	Q9BSH5
DHQWKARRLQKMEAS	CDC42BPG	726	Q6DT37
DKWMENLRRAVHPNK	DAB2IP	191	Q5VWQ8
WKRMFFERHLENLLK	TCTE1	151	Q5JU00
WKAIMAHVPARQLRR	ESPNL	811	Q6ZVH7
KSQTILRRHMAKCVW	KAT7	376	O95251
NRRMKWRHSKEAQAQ	HLX	326	Q14774
HFVKQLRMWQKIEDV	GREB1	996	Q4ZG55
IIWSLRQRQMDRHAK	HCAR2	211	Q8TDS4
LAASHRMWALQRLRK	HERC2	3766	O95714
THSMNRLWRKNKSIR	CPA5	246	Q8WXQ8
LLWLQKRIEMHKAEQ	HMGN2P46	26	Q86SG4
TRRKVDWLTEKMHAR	EIF4A1	281	P60842
TERHIKIWFQNRRMK	PDX1	186	P52945
DMKTAIRQLRKWDAH	OR4F5	286	Q8NH21
NEDVKAAMWKLRNRH	OR4K1	291	Q8NGD4
AVKRHNLTKRWLMKI	NDUFAF6	141	Q330K2
LLARSLEVRHMKNWI	PRCP	471	P42785
MVEPHQKVAWKRAVR	KDM3B	1011	Q7LBC6
WMNSKILHIKQDERV	L1CAM	171	P32004
DAIKWRLRNHMAFLV	TUBGCP4	511	Q9UGJ1
IKNHWNSTMRRKVEQ	MYB	181	P10242
RVNAKDNMWLTPLHR	ANKRD44	66	Q8N8A2
DMKTAIRQLRKWDAH	OR4F17	286	Q8NGA8
VAMVERWKQAAKQRL	NOC2L	151	Q9Y3T9
RDSHMKQLLLIQERW	NRBF2	61	Q96F24
QVKVWFQNRRMKHKR	HOXB2	186	P14652
KRMWHQALLRSGDKV	CTSA	311	P10619
AVSAIHKLMRWIRKE	MON1A	626	Q86VX9
EHTWKKNLFERMEAR	EFCAB5	111	A4FU69
ASLNKGRWRHKMAVL	KLHL24	391	Q6TFL4
WDLRMKLHDRGAQVI	DNAAF3	211	Q8N9W5
HMALERNSWLQKRIE	CCDC106	66	Q9BWC9
WATLRMERGAKEKNH	GPAT4	56	Q86UL3
AQKVINWHMKIEELR	CEP290	1341	O15078
NWHMKIEELRLQELK	CEP290	1346	O15078
ELAHMQALAEEWKKR	CEP120	676	Q8N960
EKQIKHFGMLRRWDD	CDC37	156	Q16543
TRKAHRIEQMVARWL	FRMPD1	11	Q5SYB0
IAIAQAMRAHTWREK	CCR9	146	P51686
MHLKREEKLSRHQVW	DRC7	676	Q8IY82
NTRRKVDWLTEKMHA	EIF4A2	281	Q14240
HKTKIRESLMNQSRW	COMMD1	101	Q8N668
LKMVWRINPAHRKLQ	DYNC1H1	446	Q14204
EALKDRHWKQLMKRL	DYNC1H1	1406	Q14204
RKLEDRKWHSMASLN	GRID1	336	Q9ULK0
ERNMLERGKAEWHKL	CCDC144A	1186	A2RUR9
HVKTDWDRAKSQKMR	COLGALT1	581	Q8NBJ5
HRKEMLNLWQKIRGD	EFCAB3	346	Q8N7B9
AREMLRQSLSWRKQH	SEC14L5	281	O43304
EKIERRKMLLQWYQH	RXYLT1	406	Q9Y2B1
IKNHWNSTMRRKVEQ	MYBL1	176	P10243
KGRIWMHKERQENVQ	C9orf72	141	Q96LT7
RKLWLMHAQVATIER	LRRC4B	256	Q9NT99
SKLKDIRNAWKHSRM	MRTO4	51	Q9UKD2
WQQMFKVELKRLQRH	MR1	91	Q95460
RLKALGDELHQRTMW	HRK	36	O00198
QVKVWFQNRRMKHKR	HOXA2	186	O43364
DMKTAIRRLRKWDAH	OR4F4	286	Q96R69
KGRAWIRVALMEKHL	RUNDC3B	141	Q96NL0
LARKMALRRAFTHWK	SFI1	346	A8K8P3
ARQLRLAFLMHSWKD	CARS1	426	P49589
WKIRKTIMQLCHDRG	POLR2E	11	P19388
ERDQAAKHRFSWMKL	F5	871	P12259
NRRTKWRKKHAAEMA	NKX6-1	286	P78426
MAVDIGRHRWDQVKK	NBPF12	866	Q5TAG4
LAMHILWELRKKFRC	SAMD9	746	Q5K651
IIWSLRQRQMDRHAK	HCAR3	211	P49019
VWAAHNKDVLRRMKK	ARL6IP5	81	O75915
HLLMLDTWQKDRARR	EPHB6	891	O15197
MAWRHLKKRAQDAVI	DHODH	1	Q02127
QVIVCDMAVKRKWHF	PKD1L3	826	Q7Z443
MLRSWRERVDHLLKQ	VPS8	496	Q8N3P4
RKWVLAMKRLDVNAA	THAP6	36	Q8TBB0
QGLRKHWEDLRQAMA	SPTBN5	2231	Q9NRC6
KRLRDNHEWKKLIMV	RNASET2	26	O00584
EIKNKQRRHLMFTRW	RPF1	56	Q9H9Y2
NRKWTVVHAGARRMK	ULBP3	156	Q9BZM4
RKEAASWARRMHLAL	TIMELESS	426	Q9UNS1
RQRASLNWHMKKHTA	ZNF653	566	Q96CK0
KVARLDNIFLTRMHW	ELAC2	101	Q9BQ52
HRLQARKAMWRKEQD	TICAM1	531	Q8IUC6
QRAIFKQAMRHWEKH	TLL2	176	Q9Y6L7
SWHVKDNRVMQLTRK	SLFN12	321	Q8IYM2
KRWLRHQAFMAELAQ	SPTBN4	1341	Q9H254
RRQAVAWLVAMHKAA	ZFYVE21	211	Q9BQ24
AFMVWAKDERKRLAQ	SOX18	91	P35713
RTLKMAINRWLETHQ	WDSUB1	461	Q8N9V3
VNRFHLKKKMRVWRD	SULF2	396	Q8IWU5
ERLERQHWTMTKIQK	TRIM28	326	Q13263
HEWNQKRARKAMRNG	N4BP2L1	96	Q5TBK1
KMRAGRRLWAHLIEK	MMUT	321	P22033
RRLWAHLIEKMFQPK	MMUT	326	P22033