Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ankyrin binding	PTPRC SPTB SPTBN1	6.66e-05	23	69	3	GO:0030506
GeneOntologyCellularComponent	cell cortex	FNBP1 SPTB SPTBN1 UNC13C RTKN GSN C2CD5	2.20e-04	371	69	7	GO:0005938
GeneOntologyCellularComponent	cortical actin cytoskeleton	SPTB SPTBN1 RTKN GSN	2.54e-04	93	69	4	GO:0030864
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTB SPTBN1	3.81e-04	9	69	2	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTB SPTBN1	3.81e-04	9	69	2	GO:0008091
GeneOntologyCellularComponent	cortical cytoskeleton	SPTB SPTBN1 RTKN GSN	8.78e-04	129	69	4	GO:0030863
GeneOntologyCellularComponent	npBAF complex	SMARCC1 SMARCC2	9.52e-04	14	69	2	GO:0071564
GeneOntologyCellularComponent	brahma complex	SMARCC1 SMARCC2	9.52e-04	14	69	2	GO:0035060
GeneOntologyCellularComponent	RSC-type complex	SMARCC1 SMARCC2	1.10e-03	15	69	2	GO:0016586
GeneOntologyCellularComponent	nBAF complex	SMARCC1 SMARCC2	1.25e-03	16	69	2	GO:0071565
Domain	SMARCC_C	SMARCC1 SMARCC2	1.35e-05	2	69	2	IPR032451
Domain	SMARCC_N	SMARCC1 SMARCC2	1.35e-05	2	69	2	IPR032450
Domain	SWIRM-assoc	SMARCC1 SMARCC2	1.35e-05	2	69	2	IPR032448
Domain	SWIRM-assoc_2	SMARCC1 SMARCC2	1.35e-05	2	69	2	PF16496
Domain	SWIRM-assoc_1	SMARCC1 SMARCC2	1.35e-05	2	69	2	PF16495
Domain	SWIRM-assoc_3	SMARCC1 SMARCC2	1.35e-05	2	69	2	PF16498
Domain	Spectrin_bsu	SPTB SPTBN1	8.03e-05	4	69	2	IPR016343
Domain	HR1_rho-bd	FNBP1 RTKN CCDC70	1.05e-04	25	69	3	IPR011072
Domain	SWIRM	SMARCC1 SMARCC2	2.00e-04	6	69	2	PS50934
Domain	SWIRM	SMARCC1 SMARCC2	2.00e-04	6	69	2	PF04433
Domain	SWIRM	SMARCC1 SMARCC2	2.00e-04	6	69	2	IPR007526
Domain	Chromo/shadow_dom	CHD5 SMARCC1 SMARCC2	2.43e-04	33	69	3	IPR000953
Domain	CHROMO	CHD5 SMARCC1 SMARCC2	2.43e-04	33	69	3	SM00298
Domain	PTPc	PTPN7 PTPRA PTPRC	3.16e-04	36	69	3	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN7 PTPRA PTPRC	4.01e-04	39	69	3	PS50055
Domain	PTPase_domain	PTPN7 PTPRA PTPRC	4.65e-04	41	69	3	IPR000242
Domain	Y_phosphatase	PTPN7 PTPRA PTPRC	4.65e-04	41	69	3	PF00102
Domain	MBOAT_fam	HHAT HHATL	7.24e-04	11	69	2	IPR004299
Domain	MBOAT	HHAT HHATL	7.24e-04	11	69	2	PF03062
Domain	TPR_8	TMTC3 TTC21B PEX5L	9.90e-04	53	69	3	PF13181
Domain	Ras_G-nucl-exch_fac_CS	RAPGEF5 RASGEF1B	1.19e-03	14	69	2	IPR019804
Domain	PTPc_motif	PTPN7 PTPRA PTPRC	1.35e-03	59	69	3	SM00404
Domain	Tyr_Pase_cat	PTPN7 PTPRA PTPRC	1.35e-03	59	69	3	IPR003595
Domain	CH	MICALL2 SPTB SPTBN1	1.79e-03	65	69	3	SM00033
Domain	KRAB	ZNF514 ZNF26 ZNF211 ZNF268 ZNF214 ZNF471	2.07e-03	358	69	6	PS50805
Domain	KRAB	ZNF514 ZNF26 ZNF211 ZNF268 ZNF214 ZNF471	2.07e-03	358	69	6	PF01352
Domain	CH	MICALL2 SPTB SPTBN1	2.21e-03	70	69	3	PF00307
Domain	-	MICALL2 SPTB SPTBN1	2.30e-03	71	69	3	1.10.418.10
Domain	KRAB	ZNF514 ZNF26 ZNF211 ZNF268 ZNF214 ZNF471	2.40e-03	369	69	6	SM00349
Domain	KRAB	ZNF514 ZNF26 ZNF211 ZNF268 ZNF214 ZNF471	2.43e-03	370	69	6	IPR001909
Domain	RasGEFN	RAPGEF5 RASGEF1B	2.45e-03	20	69	2	SM00229
Domain	RCC1	HERC2 HERC1	2.45e-03	20	69	2	PF00415
Domain	CH	MICALL2 SPTB SPTBN1	2.49e-03	73	69	3	PS50021
Domain	Tyr_Pase_AS	PTPN7 PTPRA PTPRC	2.49e-03	73	69	3	IPR016130
Domain	CH-domain	MICALL2 SPTB SPTBN1	2.69e-03	75	69	3	IPR001715
Domain	RasGEF_N	RAPGEF5 RASGEF1B	2.70e-03	21	69	2	PF00618
Domain	RCC1_1	HERC2 HERC1	2.70e-03	21	69	2	PS00625
Domain	RCC1_2	HERC2 HERC1	2.70e-03	21	69	2	PS00626
Domain	RCC1_3	HERC2 HERC1	2.70e-03	21	69	2	PS50012
Domain	Reg_chr_condens	HERC2 HERC1	2.96e-03	22	69	2	IPR000408
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF5 RASGEF1B	2.96e-03	22	69	2	IPR000651
Domain	-	HERC2 HERC1	2.96e-03	22	69	2	2.130.10.30
Domain	RASGEF_NTER	RAPGEF5 RASGEF1B	2.96e-03	22	69	2	PS50212
Domain	Actinin_actin-bd_CS	SPTB SPTBN1	3.24e-03	23	69	2	IPR001589
Domain	-	CHRNA6 HTR3B	3.24e-03	23	69	2	1.20.120.370
Domain	Spectrin	SPTB SPTBN1	3.24e-03	23	69	2	PF00435
Domain	Acetylcholine_rcpt_TM	CHRNA6 HTR3B	3.24e-03	23	69	2	IPR027361
Domain	ACTININ_2	SPTB SPTBN1	3.24e-03	23	69	2	PS00020
Domain	ACTININ_1	SPTB SPTBN1	3.24e-03	23	69	2	PS00019
Domain	RCC1/BLIP-II	HERC2 HERC1	3.24e-03	23	69	2	IPR009091
Domain	NUDIX_BOX	NUDT18 TRPM2	3.52e-03	24	69	2	PS00893
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 ATF6 PTPRA COPB1 SPTB SPTBN1 ZNF214 NUP42 HERC2 HERPUD2 PRPF8 NSUN2 PTGES3 MADD	2.30e-07	1285	70	14	35914814
Pubmed	Functional selectivity of recombinant mammalian SWI/SNF subunits.	KLF1 SMARCC1 SMARCC2	1.27e-06	11	70	3	11018012
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PPP1R7 PTPN7 PTPRA TRPM2 GEMIN4 HERC1 PRPF8 NSUN2 PTGES3	2.24e-06	573	70	9	28330616
Pubmed	The Swi3 protein plays a unique role in regulating respiration in eukaryotes.	SMARCC1 SMARCC2	3.99e-06	2	70	2	27190130
Pubmed	Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.	PTPRA PTPRC	3.99e-06	2	70	2	17507376
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 COPB1 SPTBN1 GEMIN4 SMARCC1 SMARCC2 HERC2 PRPF8 NSUN2	6.44e-06	653	70	9	22586326
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTB SPTBN1	1.20e-05	3	70	2	11294830
Pubmed	The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells.	PTPN7 PTPRA	1.20e-05	3	70	2	12592337
Pubmed	Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells.	PTPRC SPTB	1.20e-05	3	70	2	20164196
Pubmed	Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.	HHAT HHATL	1.20e-05	3	70	2	18081866
Pubmed	Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.	PTPRA PTPRC	1.20e-05	3	70	2	20505149
Pubmed	Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.	PTPRA PTPRC	1.20e-05	3	70	2	9535845
Pubmed	BAF chromatin remodeling complex: cortical size regulation and beyond.	SMARCC1 SMARCC2	1.20e-05	3	70	2	23974113
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	1.20e-05	3	70	2	8479293
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTB SPTBN1	1.20e-05	3	70	2	32425157
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	1.20e-05	3	70	2	1467942
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	PTPRA SPTB SPTBN1	1.74e-05	25	70	3	8493579
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	ZNF26 PTPRA MICALL2 SPTBN1 HERC1 NSUN2	2.07e-05	277	70	6	30745168
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	TRHDE PTPN7 ABCA1 PTPRA RASGEF1B HERC2 HERC1	2.22e-05	420	70	7	28065597
Pubmed	Comparison of CD45 extracellular domain sequences from divergent vertebrate species suggests the conservation of three fibronectin type III domains.	PTPRA PTPRC	2.39e-05	4	70	2	8759740
Pubmed	Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.	HERC2 CRY1	2.39e-05	4	70	2	20304803
Pubmed	Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.	PTPRC CD101	2.39e-05	4	70	2	25421756
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTB SPTBN1	2.39e-05	4	70	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTB SPTBN1	2.39e-05	4	70	2	3862089
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTB SPTBN1	2.39e-05	4	70	2	21412925
Pubmed	Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells.	PTPRA PTPRC	2.39e-05	4	70	2	8980254
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTB SPTBN1	2.39e-05	4	70	2	12820899
Pubmed	The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization.	SMARCC1 SMARCC2	2.39e-05	4	70	2	15150092
Pubmed	Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.	SMARCC1 SMARCC2	3.98e-05	5	70	2	9693044
Pubmed	Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.	PTPN7 PTPRC	3.98e-05	5	70	2	10415025
Pubmed	Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.	SMARCC1 SMARCC2	3.98e-05	5	70	2	16199878
Pubmed	Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes.	SMARCC1 SMARCC2	3.98e-05	5	70	2	12244326
Pubmed	Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt.	SMARCC1 SMARCC2	3.98e-05	5	70	2	16568092
Pubmed	The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo.	SMARCC1 SMARCC2	3.98e-05	5	70	2	18086889
Pubmed	p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.	SMARCC1 SMARCC2	3.98e-05	5	70	2	9584200
Pubmed	The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production.	PTPRC SPTB	3.98e-05	5	70	2	12354383
Pubmed	Major erythrocyte membrane protein genes in EKLF-deficient mice.	KLF1 SPTB	3.98e-05	5	70	2	16728274
Pubmed	Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.	PTPRA PTPRC	3.98e-05	5	70	2	2169617
Pubmed	Variations in the composition of mammalian SWI/SNF chromatin remodelling complexes.	SMARCC1 SMARCC2	5.96e-05	6	70	2	19650111
Pubmed	Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.	SMARCC1 SMARCC2	5.96e-05	6	70	2	16940996
Pubmed	Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.	SMARCC1 SMARCC2	5.96e-05	6	70	2	21095589
Pubmed	Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia.	SPTBN1 GSN	5.96e-05	6	70	2	15310273
Pubmed	The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest.	SMARCC1 SMARCC2	5.96e-05	6	70	2	16230384
Pubmed	BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.	SMARCC1 SMARCC2	5.96e-05	6	70	2	10943845
Pubmed	Varying modulation of HIV-1 LTR activity by Baf complexes.	SMARCC1 SMARCC2	5.96e-05	6	70	2	21699904
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	FNBP1 GPR161 PTPRA HERC2 NSUN2 DHRS1 RTP4 HHATL	7.90e-05	697	70	8	28298427
Pubmed	Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.	SMARCC1 SMARCC2	8.33e-05	7	70	2	16601680
Pubmed	BRIT1/MCPH1 links chromatin remodelling to DNA damage response.	SMARCC1 SMARCC2	8.33e-05	7	70	2	19525936
Pubmed	Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.	PTPRA PTPRC	8.33e-05	7	70	2	1454056
Pubmed	Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.	PTPRA PTPRC	8.33e-05	7	70	2	12376545
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC1	8.33e-05	7	70	2	9949213
Pubmed	Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.	SMARCC1 SMARCC2	8.33e-05	7	70	2	28369036
Pubmed	Target genes of the largest human SWI/SNF complex subunit control cell growth.	SMARCC1 SMARCC2	8.33e-05	7	70	2	21118156
Pubmed	The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.	ABCA1 PRPF8	8.33e-05	7	70	2	12054535
Pubmed	Transmembrane homodimerization of receptor-like protein tyrosine phosphatases.	PTPRA PTPRC	8.33e-05	7	70	2	15978577
Pubmed	Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.	PTPRA PTPRC	8.33e-05	7	70	2	1932742
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	COPB1 SPTBN1 TRPM2 GEMIN4 SMARCC1 SMARCC2 HERC2 PRPF8 DCUN1D3 NSUN2 PARP12	8.77e-05	1371	70	11	36244648
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	SPTBN1 GEMIN4 HERC1 PRPF8 NSUN2	1.05e-04	231	70	5	36597993
Pubmed	CHD7 cooperates with PBAF to control multipotent neural crest formation.	SMARCC1 SMARCC2	1.11e-04	8	70	2	20130577
Pubmed	The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis.	SMARCC1 SMARCC2	1.11e-04	8	70	2	36335117
Pubmed	Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.	SMARCC1 SMARCC2	1.11e-04	8	70	2	26986003
Pubmed	The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.	SMARCC1 SMARCC2	1.11e-04	8	70	2	28940253
Pubmed	Critical role of the BAF chromatin remodeling complex during murine neural crest development.	SMARCC1 SMARCC2	1.11e-04	8	70	2	33750945
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NUDT18 PPP1R7 TPP2 PTPRA COPB1 SPTB SPTBN1 SMARCC2 PTGES3 GSN MADD	1.28e-04	1431	70	11	37142655
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PPP1R7 TPP2 GPRASP1 SPTBN1 SMARCC1 SMARCC2 HERC2 PEX5L GSN	1.32e-04	963	70	9	28671696
Pubmed	Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.	SMARCC1 SMARCC2	1.42e-04	9	70	2	20086098
Pubmed	Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.	FNBP1 NUP42	1.42e-04	9	70	2	20139417
Pubmed	The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.	SMARCC1 SMARCC2	1.42e-04	9	70	2	37805104
Pubmed	Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization.	COPB1 SPTBN1	1.42e-04	9	70	2	21866423
Pubmed	EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.	SMARCC1 SMARCC2	1.42e-04	9	70	2	22513373
Pubmed	Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.	SMARCC1 SMARCC2	1.42e-04	9	70	2	9845365
Pubmed	Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.	COPB1 SMARCC1 SMARCC2	1.43e-04	50	70	3	27716508
Pubmed	A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.	SMARCC2 PRPF8 NSUN2	1.52e-04	51	70	3	26839216
Pubmed	Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.	SMARCC1 SMARCC2	1.78e-04	10	70	2	16751102
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTB SPTBN1	1.78e-04	10	70	2	22159418
Pubmed	Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.	SMARCC1 SMARCC2	1.78e-04	10	70	2	12665591
Pubmed	Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.	SMARCC1 SMARCC2	1.78e-04	10	70	2	11238380
Pubmed	A methylation-mediator complex in hormone signaling.	SMARCC1 SMARCC2	1.78e-04	10	70	2	14729568
Pubmed	Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance.	SMARCC1 SMARCC2	1.78e-04	10	70	2	34716243
Pubmed	The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.	SMARCC1 SMARCC2 GSN	1.90e-04	55	70	3	35945219
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTB SPTBN1	2.17e-04	11	70	2	17607528
Pubmed	BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.	SMARCC1 SMARCC2	2.17e-04	11	70	2	12917342
Pubmed	Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.	PTPRC SPTBN1	2.17e-04	11	70	2	24337748
Pubmed	Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.	SMARCC1 SMARCC2	2.17e-04	11	70	2	18003620
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FNBP1 COPB1 SPTBN1 GEMIN4 SMARCC1 PRPF8 NSUN2 PTGES3	2.19e-04	809	70	8	32129710
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP1R7 TPP2 PTPN7 PTPRA PTPRC SPTBN1 HERC2 HERC1 MADD	2.49e-04	1049	70	9	27880917
Pubmed	Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain.	SMARCC1 SMARCC2	2.60e-04	12	70	2	34336815
Pubmed	SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.	SMARCC1 SMARCC2	2.60e-04	12	70	2	11734557
Pubmed	Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm.	SMARCC1 SMARCC2	2.60e-04	12	70	2	33723076
Pubmed	A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice.	SMARCC1 SMARCC2	3.07e-04	13	70	2	24170322
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTB SPTBN1	3.07e-04	13	70	2	18796539
Pubmed	Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.	SMARCC1 SMARCC2	3.07e-04	13	70	2	11726552
Pubmed	Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1.	SMARCC1 SMARCC2	3.07e-04	13	70	2	17340523
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FNBP1 PTPRC RAPGEF5 SPTBN1 SMARCC1 HERC1 MADD C2CD5 PARP12	3.17e-04	1084	70	9	11544199
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	TRHDE ATF6 TMTC3 SPTBN1	3.43e-04	164	70	4	32409323
Pubmed	Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.	SMARCC1 SMARCC2	3.58e-04	14	70	2	8895581
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	SPTBN1 SMARCC1 SMARCC2 PRPF8	3.93e-04	170	70	4	16159877
Pubmed	Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.	SMARCC1 SMARCC2	4.12e-04	15	70	2	23785148
Pubmed	An essential switch in subunit composition of a chromatin remodeling complex during neural development.	SMARCC1 SMARCC2	4.12e-04	15	70	2	17640523
Pubmed	The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.	SMARCC1 SMARCC2	4.12e-04	15	70	2	11263494
GeneFamily	Membrane bound O-acyltransferases	HHAT HHATL	1.75e-04	7	53	2	1036
GeneFamily	EF-hand domain containing\|Spectrins	SPTB SPTBN1	1.75e-04	7	53	2	1113
GeneFamily	Dynein regulatory complex	IQCA1 DRC1	4.56e-04	11	53	2	981
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRA PTPRC	1.71e-03	21	53	2	813
GeneFamily	Nudix hydrolase family	NUDT18 TRPM2	2.23e-03	24	53	2	667
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TMTC3 TTC21B PEX5L	4.66e-03	115	53	3	769
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF514 ZNF26 ZNF211 KLF1 ZNF268 ZNF214 ZNF471	4.76e-03	718	53	7	28
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE GPR161 IQCA1 UNC13C PDE7B	7.84e-06	173	70	5	8335b77f730ed43fc348a005566e73a103c6774b
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN7 TMTC3 UNC13C NUP42 PDE7B	8.07e-06	174	70	5	c58328c2f262506a4518f49f148e29874faf9171
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE RAPGEF5 HHAT UNC13C PDE7B	1.11e-05	186	70	5	bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCell	COPD-Lymphoid-T_Cytotoxic\|COPD / Disease state, Lineage and Cell class	FNBP1 PTPN7 LINC01619 PTPRC HERPUD2	1.33e-05	193	70	5	58e94fe2e89cdafc6974938f97a4c162061a437d
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GPRASP1 CHD5 HERC2 HERC1 MADD	1.36e-05	194	70	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNBP1 PTPRA RTKN PEX5L GSN	1.58e-05	200	70	5	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTB SPTBN1	2.95e-05	4	66	2	DOID:0050882 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	CHRNA6 SMARCC1 SMARCC2 UNC13C MADD	7.72e-05	195	66	5	DOID:1574 (implicated_via_orthology)
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	SMARCC1 SMARCC2	1.76e-04	9	66	2	DOID:0050340 (implicated_via_orthology)
Disease	Coffin-Siris syndrome (implicated_via_orthology)	SMARCC1 SMARCC2	1.76e-04	9	66	2	DOID:1925 (implicated_via_orthology)
Disease	glaucoma	ABCA1 RAPGEF5 HERC2 PDE7B	4.00e-04	154	66	4	MONDO_0005041
Disease	reticulocyte count	ABCA1 PTPRA PTPRC COPB1 KLF1 SPTB HERC1 PRPF8 PTGES3	5.12e-04	1045	66	9	EFO_0007986
Disease	anorectal malformation	TRPM2 NLRP8	8.22e-04	19	66	2	MONDO_0019938
Disease	blood metabolite measurement	PTPRA GNMT	8.22e-04	19	66	2	EFO_0005664
Disease	hemoglobin A1 measurement	GPR161 IL13RA1 PTPRA SPTB GSN MADD	1.08e-03	520	66	6	EFO_0007629
Disease	Vitiligo	PTPRC HERC2 PARP12	1.52e-03	101	66	3	EFO_0004208
Disease	Hypermetropia	HHAT RASGEF1B ANKFN1	1.61e-03	103	66	3	HP_0000540
Disease	chronic kidney disease	MICALL2 SPTBN1 HTR3B MADD	1.92e-03	235	66	4	EFO_0003884
Disease	survival time, coronary artery disease	CD101 UNC13C	2.06e-03	30	66	2	EFO_0000714, EFO_0001645

Protein segments in the cluster

Peptide	Gene	Start	Entry
VSLLDEDVWEFIWMK	TRHDE	861	Q9UKU6
MNWNAIDAEEFEKSW	TTC21B	1186	Q7Z4L5
IINWEREFEMWAPDF	CHD5	761	Q8TDI0
KEEVWSFEAGDLEWM	AAMP	166	Q13685
EVWNDEFLSWNSSMF	HTR3B	86	O95264
WEELSPKIWTFMENS	ABCA1	416	O95477
DFDLDLMPWESDIWD	ATF6	61	P18850
EEENALWEEERAFWM	CCDC70	186	Q6NSX1
WPSLFDTFVEWEMER	DCUN1D3	266	Q8IWE4
WMKKDESWNFSQDYD	IQCA1	406	Q86XH1
VSDFWEMVWQEEVSL	PTPN7	176	P35236
VMTKDGQWFTDWDAV	NSUN2	366	Q08J23
RKMDVADFEWVMWFT	HHATL	56	Q9HCP6
TLWDQMQFWEDAFLD	MADD	1316	Q8WXG6
RGENFSWWKVMEEDL	NUDT18	291	Q6ZVK8
NVMEKFFPIWDITTW	NLRP8	156	Q86W28
IQWFWEVMESFSNTE	HERC2	4701	O95714
LWISMQDYAVSKDWD	HERC1	1236	Q15751
DDAEDSLMVDWFWLI	MICALL2	771	Q8IY33
DTEFWDKMQAEWEEM	PEX5L	276	Q8IYB4
WEMSKQWSERVCEEF	PDE7B	331	Q9NP56
TDAEFRQMWAEFEWE	COPB1	836	P53618
PAFDKWVIEEANWMT	GNMT	106	Q14749
KFWELAKQVSEFMTW	RASGEF1B	401	Q0VAM2
ALIDDEKFWEIWLMN	DRC1	391	Q96MC2
YEDDKLWSNWSQEMS	IL13RA1	321	P78552
VKDMEVWESSGQWMF	NUP42	121	O15504
WQFLDRGKWEDLDNM	PARP12	301	Q9H0J9
LKKDATDFEWSFWME	HHAT	51	Q5VTY9
DMNDFWENSEWEIID	CHRNA6	196	Q15825
ATEWIQDPDETWMFI	CD101	251	Q93033
DFLKWWRSEEAQDMG	KLF1	26	Q13351
MSWGTELWDQFDNLE	FNBP1	1	Q96RU3
WISWEEGMKVFEELL	CRY1	371	Q16526
WSSVEFDEFKWMCVA	GPR161	166	Q8N6U8
DDVMLLDTWDQVFVW	GSN	696	P06396
VLNEEDFNRDWLDWM	HERPUD2	266	Q9BSE4
KAFWETPASMWDDIN	DHRS1	106	Q96LJ7
FWMNDNLLESWSDLD	PPP1R7	301	Q15435
LITWKEFQSFMPWDI	SLC13A1	421	Q9BZW2
WNSEWFKFEVDDEDL	C2CD5	51	Q86YS7
PKEETVNDFWRMIWE	PTPRA	316	P18433
DDEEMIVESWFWSRD	GPRASP1	931	Q5JY77
SWMEALWQLFFDMSQ	RTKN	406	Q9BST9
MVVDFWTWEQTFQEL	RTP4	1	Q96DX8
TWDLALELMNFDWSL	RAPGEF5	346	Q92565
HVKWILDTDIFNEWM	SMARCC1	266	Q92922
WILDTDTFNEWMNEE	SMARCC2	241	Q8TAQ2
ESRRLWKFFWEMAEE	SPTBN1	636	Q01082
WKFFWEMAEEEGWIR	SPTBN1	641	Q01082
QDFLWFTKLSCMWED	ANKFN1	476	Q8N957
MELFASWSDEKLWQL	CNBD2	241	Q96M20
KWSSKVWSMDEFDLQ	LINC01619	21	G3V211
LFWEKASGFEESMKW	PRPF8	1501	Q6P2Q9
LSFMDVFVDFTWEEW	ZNF268	81	Q14587
SLWFEPFVMQWLDEN	UNC13C	1686	Q8NB66
WKDWEDDSDEDMSNF	PTGES3	106	Q15185
DIARSEIFMDEWQWK	TRPM2	466	O94759
MTFEDVAVEFSQWEW	ZNF514	1	Q96K75
TFWETTKWTDLFDNK	TPP2	1166	P29144
YFSWEEWDLLDEAQK	ZNF211	41	Q13398
KFFWEMDEAESWIKE	SPTB	641	P11277
KCQSDWMERWVDDAF	TMEM87B	421	Q96K49
FKDVAIDFSQEEWQW	ZNF471	16	Q9BX82
FEENWKWEDLFEKQM	ZNF471	121	Q9BX82
FKDISMEFTWDEWQL	ZNF26	16	P17031
MEFTWDEWQLLDSTQ	ZNF26	21	P17031
WDWESEYTLFMSALK	TMTC3	426	Q6ZXV5
DFWFEIFDMKKWDQF	UGT2B7	221	P16662
ETVDDFWRMIWEQKA	PTPRC	731	P08575
IFTWEEWKFLDSSQK	ZNF214	11	Q9UL59
MLRKLWQWFYEETES	ZHX1-C8orf76	1	Q96EF9
DVAFFLDVWWEVMKH	GEMIN4	156	P57678