Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5-diphosphoinositol pentakisphosphate 1-kinase activity	PPIP5K1 PPIP5K2	3.91e-06	2	40	2	GO:0033857
GeneOntologyMolecularFunction	inositol hexakisphosphate 3-kinase activity	PPIP5K1 PPIP5K2	2.34e-05	4	40	2	GO:0052724
GeneOntologyMolecularFunction	inositol hexakisphosphate 1-kinase activity	PPIP5K1 PPIP5K2	2.34e-05	4	40	2	GO:0052723
GeneOntologyMolecularFunction	inositol hexakisphosphate 5-kinase activity	PPIP5K1 PPIP5K2	3.90e-05	5	40	2	GO:0000832
GeneOntologyMolecularFunction	diphosphoinositol pentakisphosphate kinase activity	PPIP5K1 PPIP5K2	3.90e-05	5	40	2	GO:0000829
GeneOntologyMolecularFunction	inositol hexakisphosphate kinase activity	PPIP5K1 PPIP5K2	3.90e-05	5	40	2	GO:0000828
GeneOntologyMolecularFunction	inositol-1,3,4,5,6-pentakisphosphate kinase activity	PPIP5K1 PPIP5K2	3.90e-05	5	40	2	GO:0000827
GeneOntologyMolecularFunction	inositol phosphate kinase activity	PPIP5K1 PPIP5K2	2.13e-04	11	40	2	GO:0180030
GeneOntologyMolecularFunction	phosphotransferase activity, phosphate group as acceptor	PPIP5K1 PPIP5K2	3.05e-03	41	40	2	GO:0016776
GeneOntologyBiologicalProcess	inositol phosphate biosynthetic process	PPIP5K1 PPIP5K2 NTSR1	2.92e-05	31	40	3	GO:0032958
Domain	Acid_Pase_AS	PPIP5K1 PPIP5K2	6.67e-05	6	40	2	IPR033379
Domain	HIS_ACID_PHOSPHAT_2	PPIP5K1 PPIP5K2	9.33e-05	7	40	2	PS00778
Domain	HIS_ACID_PHOSPHAT_1	PPIP5K1 PPIP5K2	9.33e-05	7	40	2	PS00616
Domain	His_Pase_clade-2	PPIP5K1 PPIP5K2	1.24e-04	8	40	2	IPR000560
Domain	His_Phos_2	PPIP5K1 PPIP5K2	1.24e-04	8	40	2	PF00328
Domain	His_PPase_superfam	PPIP5K1 PPIP5K2	8.29e-04	20	40	2	IPR029033
Domain	-	PPIP5K1 PPIP5K2	8.29e-04	20	40	2	3.40.50.1240
Domain	HECT	UBE3C HUWE1	1.52e-03	27	40	2	PF00632
Domain	HECTc	UBE3C HUWE1	1.52e-03	27	40	2	SM00119
Domain	HECT_dom	UBE3C HUWE1	1.52e-03	27	40	2	IPR000569
Domain	HECT	UBE3C HUWE1	1.52e-03	27	40	2	PS50237
Domain	FYVE	PIKFYVE ZFYVE26	1.75e-03	29	40	2	PF01363
Domain	FYVE	PIKFYVE ZFYVE26	1.75e-03	29	40	2	SM00064
Domain	Znf_FYVE-rel	PIKFYVE ZFYVE26	2.40e-03	34	40	2	IPR017455
Domain	Znf_FYVE	PIKFYVE ZFYVE26	2.99e-03	38	40	2	IPR000306
Domain	ZF_FYVE	PIKFYVE ZFYVE26	3.31e-03	40	40	2	PS50178
Domain	-	FBXO41 IGSF10 NLRP14 SLITRK6	4.81e-03	321	40	4	3.80.10.10
Domain	L_dom-like	FBXO41 IGSF10 NLRP14 SLITRK6	5.19e-03	328	40	4	IPR032675
Domain	MFS	SLC16A13 SLC16A12	1.18e-02	77	40	2	IPR011701
Domain	MFS_1	SLC16A13 SLC16A12	1.18e-02	77	40	2	PF07690
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	PPIP5K1 PPIP5K2	2.36e-04	10	33	2	M27051
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	PPIP5K1 PPIP5K2	2.36e-04	10	33	2	MM14709
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	FBXO41 UFL1 UBE3C HUWE1 UBR4	6.05e-04	299	33	5	MM15711
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	FBXO41 UFL1 UBE3C HUWE1 UBR4	6.92e-04	308	33	5	M1070
Pubmed	The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.	PPIP5K1 PPIP5K2	1.36e-06	2	41	2	28126903
Pubmed	Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.	PPIP5K1 PPIP5K2	1.36e-06	2	41	2	18981179
Pubmed	Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.	PPIP5K1 PPIP5K2	1.36e-06	2	41	2	17690096
Pubmed	Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.	PPIP5K1 PPIP5K2	1.36e-06	2	41	2	17702752
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	UBE3C HUWE1 UBR4	1.45e-06	19	41	3	24743594
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	UFL1 UBE3C UBR4	1.99e-06	21	41	3	37422473
Pubmed	PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.	PPIP5K1 PPIP5K2	4.06e-06	3	41	2	31852976
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	HUWE1 UBR4	8.12e-06	4	41	2	37324936
Pubmed	Activity-Based Probes for HECT E3 Ubiquitin Ligases.	UBE3C HUWE1	1.35e-05	5	41	2	28425671
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	ZFYVE26 UBR4	3.78e-05	8	41	2	37871017
Pubmed	Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.	UBE3C HUWE1	4.86e-05	9	41	2	9575161
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBE3C HUWE1 UBR4	6.61e-05	66	41	3	24811749
Pubmed	A novel LZAP-binding protein, NLBP, inhibits cell invasion.	UFL1 HUWE1	1.05e-04	13	41	2	20164180
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	HUWE1 UBR4	1.22e-04	14	41	2	27626314
Pubmed	The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.	SLC16A13 SLC16A12	1.22e-04	14	41	2	12739169
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	UBE3C HUWE1	1.61e-04	16	41	2	25723849
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBE3C HUWE1 UBR4	1.95e-04	95	41	3	29643511
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PPIP5K1 ZFYVE26 HUWE1	2.55e-04	104	41	3	9205841
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE ZFYVE26 MGAT4B UBE3C HUWE1 UBR4 NTSR1	2.80e-04	1105	41	7	35748872
Pubmed	PRDM16 expression and function in mammalian cochlear development.	POU3F2 TECTB	3.38e-04	23	41	2	35451126
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	UBE3C HUWE1	4.33e-04	26	41	2	26949039
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	UBE3C HUWE1 ATP11B UBR4	5.01e-04	313	41	4	38270169
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	HUWE1 UBR4	5.03e-04	28	41	2	35474067
Pubmed	Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.	POU3F2 NTSR1	6.17e-04	31	41	2	23895693
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	HUWE1 PLOD1 UBR4	6.47e-04	143	41	3	30397336
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	HUWE1 UBR4	6.58e-04	32	41	2	36278411
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	HUWE1 UBR4	7.00e-04	33	41	2	33567268
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	UFL1 UBE3C HUWE1 PLOD1 MAP3K6	7.05e-04	606	41	5	36538041
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	HUWE1 UBR4	8.33e-04	36	41	2	35379950
Pubmed	HIV-host interactome revealed directly from infected cells.	ITPRIP HUWE1 PLOD1	1.10e-03	172	41	3	27375898
Cytoband	Ensembl 112 genes in cytogenetic band chr6q16	POU3F2 UFL1	1.16e-03	56	41	2	chr6q16
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	PIKFYVE ZFYVE26	1.05e-03	31	28	2	81
Computational	Genes in the cancer module 478.	PLOD1 FCGRT	3.96e-04	19	17	2	MODULE_478
Disease	peptide measurement	DCAF4L2 CSMD1 ABCA13	4.39e-04	109	40	3	EFO_0010520
Disease	arginine measurement	CSMD1 HPS1	4.45e-04	23	40	2	EFO_0020990
Disease	cerebrospinal fluid clusterin measurement	CSMD1 ABCA13	1.04e-03	35	40	2	EFO_0007657
Disease	erectile dysfunction	XYLT1 POU3F2	1.49e-03	42	40	2	EFO_0004234
Disease	HETE measurement	XYLT1 NBAS	3.22e-03	62	40	2	EFO_0801166
Disease	aspartate aminotransferase to alanine aminotransferase ratio	BCAT2 FCGRT TECTB	4.16e-03	239	40	3	EFO_0010934

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHFLHSLASSSSLIY	nan	36	A8MVM7
AALLSTTHETLIHFY	CSMD1	2051	Q96PZ7
SIYHLASYLAFSLSH	ABCA13	1596	Q86UQ4
SGLSSYHLKTALLHL	ITPRIP	426	Q8IWB1
HSYLTDTLHSLISEL	MGAT4B	156	Q9UQ53
SLQSTVHYHLGSLAL	NTSR1	96	P30989
TSIFHTFSHSYLELK	KCNG4	451	Q8TDN1
SLSIHAYHSFSTGLS	DCAF4L2	191	Q8NA75
HLTESVLYHLTSSIS	FSIP2	3501	Q5CZC0
HSFTLHTLLTYATRD	MAP3K6	1241	O95382
SLGAESHLSLLYHLT	FCGRT	21	P55899
SHLSLLYHLTAVSSP	FCGRT	26	P55899
TQHTHTLLSYVHFLL	OR51S1	276	Q8NGJ8
HLYSSIEHLTTLLAS	HUWE1	111	Q7Z6Z7
SLAHLETLSHSFILS	NBAS	1961	A2RRP1
TLGHLLSLDSYRTTH	PLOD1	501	Q02809
VLLIAHYSFLSHTST	F2R	331	P25116
SHFLSSHLIIDYSLL	PIKFYVE	2006	Q9Y2I7
IGTTHFIYSNLLHST	IGSF10	1536	Q6WRI0
CHYSTLAFSLLAHVL	LACTBL1	176	A8MY62
SLSSLRAHLEYSHTY	FBXO41	21	Q8TF61
LLYTLTTAFTLAHIH	SELENOI	346	Q9C0D9
LLTSFSSLLFYICSH	GPR146	156	Q96CH1
LLVHSKLLAFYSSHS	HPS1	211	Q92902
LTLHPASSSLHYSLQ	BCAT2	86	O15382
LHLSFYLTSIYDHSI	RRAGC	211	Q9HB90
HLFYSSLLACISLHS	SLITRK6	6	Q9H5Y7
LSSFATSLKHLYLTL	SLC16A12	131	Q6ZSM3
LLVLSYLHVHTALFS	STS	281	P08842
FSSLYSFSDVLHHLI	TECTB	306	Q96PL2
SNHYSLLTSSASIVH	POU3F2	6	P20265
SYLSSLSHLNNLSHL	ATP11B	451	Q9Y2G3
IHSLSDVTLTLYHSF	XYLT1	641	Q86Y38
AFIDFSSLTSHLRSH	ZNF555	236	Q8NEP9
LASFATSLTHLYLSI	SLC16A13	96	Q7RTY0
LYFTSESHVHSLLSI	PPIP5K2	821	O43314
KSLLASLHTSRSAYH	UBR4	2526	Q5T4S7
HTSLATSHFLANYLT	ZFYVE26	1621	Q68DK2
RLYFTSESHVHSLLS	PPIP5K1	836	Q6PFW1
LHLTSVLLFQFSTHS	UFL1	686	O94874
FTYSSLLLSHRRIHS	ZNF785	321	A8K8V0
YLFSSLFSHSLISIH	UBE3C	501	Q15386
YLSTSLLHNKSLTHL	NLRP14	891	Q86W24