Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainKinase-like_dom

BRAF GUCY2F ROR1 DCLK3 MASTL DNM3 PRKDC TRRAP DYRK2

1.64e-04542699IPR011009
DomainFAT

PRKDC TRRAP

2.00e-046692PS51189
DomainFATC

PRKDC TRRAP

2.00e-046692PS51190
DomainFAT

PRKDC TRRAP

2.00e-046692PF02259
DomainPIK-rel_kinase_FAT

PRKDC TRRAP

2.00e-046692IPR003151
DomainFATC_dom

PRKDC TRRAP

2.00e-046692IPR003152
DomainPIK_FAT

PRKDC TRRAP

2.00e-046692IPR014009
DomainFATC

PRKDC TRRAP

2.00e-046692SM01343
DomainTPR-like_helical_dom

TMTC3 TTC21A PDCD11 PRKDC MAU2 TRRAP

2.20e-04233696IPR011990
DomainHEAT

HEATR4 PRKDC ECPAS

7.41e-0448693PF02985
Domain-

TMTC3 TTC21A PDCD11 MAU2 TRRAP

1.01e-032076951.25.40.10
DomainHEAT

HEATR4 PRKDC ECPAS

1.29e-0358693IPR000357
Domain-

PRKDC TRRAP

1.56e-03166921.10.1070.11
DomainPI3Kc

PRKDC TRRAP

1.56e-0316692SM00146
DomainPI3/4_kinase_cat_dom

PRKDC TRRAP

1.98e-0318692IPR000403
DomainPI3_PI4_kinase

PRKDC TRRAP

1.98e-0318692PF00454
DomainPI3_4_KINASE_3

PRKDC TRRAP

1.98e-0318692PS50290
DomainPI3_4_KINASE_1

PRKDC TRRAP

1.98e-0318692PS00915
DomainPI3_4_KINASE_2

PRKDC TRRAP

1.98e-0318692PS00916
DomainHEAT_REPEAT

HEATR4 PRKDC ECPAS

2.21e-0370693PS50077
DomainTPR-contain_dom

TMTC3 TTC21A PDCD11 PRKDC

2.31e-03150694IPR013026
DomainARM-like

STAG1 HEATR4 PRKDC ECPAS TRRAP

3.22e-03270695IPR011989
DomainTPR_REGION

TMTC3 TTC21A PRKDC MAU2

3.25e-03165694PS50293
DomainTPR

TMTC3 TTC21A PRKDC MAU2

3.25e-03165694PS50005
DomainARM-type_fold

STAG1 HEATR4 PRKDC ECPAS TRRAP

8.33e-03339695IPR016024
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

NUP107 PDCD11 RNF213 U2AF2 PRKDC

1.27e-0514472535681168
Pubmed

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

BRAF ROR1 PRKDC RRM2

1.48e-057172428319113
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

NUP107 STAG1 PDCD11 PRKDC MAU2 TRRAP

2.20e-0527272631010829
Pubmed

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

BRAF PRKDC

4.21e-05572225848750
Pubmed

In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.

STAG1 MAU2

6.31e-05672222628566
Pubmed

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.

PRKDC CDC45

8.82e-05772220818375
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

U2AF2 RECQL PRKDC ECPAS TRRAP

9.59e-0522072535785414
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

RINT1 TMTC3 NUP107 VPS4A SEC23IP POFUT1 PRKDC ECPAS STT3A

1.40e-0494272931073040
Pubmed

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.

STAG1 MAU2

1.51e-04972216682347
Pubmed

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.

BRAF PRKDC

1.51e-04972230905671
Pubmed

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.

MYH6 RABGGTA

1.88e-041072210737774
Pubmed

Tel2 regulates the stability of PI3K-related protein kinases.

PRKDC TRRAP

1.88e-041072218160036
Pubmed

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PRKDC TRRAP

2.30e-041172220427287
Pubmed

Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.

MYH6 RYR2

2.30e-041172227766308
Pubmed

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

MYH6 RYR2

2.75e-041272223715556
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

TMTC3 NUP107 SEC23IP PDCD11 RRM2 BICC1

3.74e-0445772632344865
Pubmed

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.

WDR87 ECPAS

3.78e-041472228878358
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NUP107 PDCD11 U2AF2 RECQL PRKDC ECPAS TRRAP

4.08e-0465372722586326
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

RINT1 TMTC3 NUP107 FAM3A PRKDC ECPAS STT3A

4.23e-0465772736180527
Pubmed

High-resolution genetic mapping of the gunmetal gene which regulates platelet production.

MYH6 RABGGTA

4.36e-04157228833241
Pubmed

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.

MYH6 RYR2

4.36e-041572217360443
Pubmed

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.

NUP107 PRKDC STT3A

4.58e-047272336376293
Pubmed

Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.

MYH6 RNF213

4.98e-041672229859889
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

RNF213 PRKDC TRRAP

5.37e-047672327542412
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

MYH6 RYR2

5.63e-041772227725084
Pubmed

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.

RINT1 CDC45

5.63e-041772232548123
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

FBXO38 NUP107 RNF213 U2AF2 PRKDC

6.38e-0433272532786267
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

NUP107 VPS4A SEC23IP PDCD11 U2AF2 RECQL PRKDC ECPAS STT3A CDC45

6.86e-041425721030948266
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

MBTD1 STEEP1 PDCD11 U2AF2 TRRAP

7.00e-0433972530415952
Pubmed

Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.

STAG1 MAU2

7.06e-041972223920377
Pubmed

Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.

MYH6 RYR2

7.06e-041972218316483
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

NUP107 STAG1 RNF213 ECPAS TRRAP

7.19e-0434172532971831
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

RNF213 RNF217 ZNRF2

7.44e-048572319028597
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYH6 INTU RINT1 STAG1 KIAA0825 SEC23IP U2AF2 POFUT1 PRKDC RYR2

7.52e-041442721035575683
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

TMTC3 NUP107 PRKDC ECPAS

8.35e-0420272433005030
Pubmed

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

BRAF PDCD11 ECPAS

8.50e-048972327034005
Pubmed

New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.

MYH6 BRAF

8.65e-042172225035421
Pubmed

Glucocorticoid receptor is required for foetal heart maturation.

MYH6 RYR2

9.50e-042272223595884
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PLEKHG4B ENOSF1 INTU TTC21A EXOC6B RNF213 U2AF2 ECPAS TRRAP STT3A

9.60e-041489721028611215
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

HARS2 RINT1 NUP107 SEC23IP PDCD11 RNF213 U2AF2 ARMCX4 STT3A CDC45

9.95e-041496721032877691
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

NUP107 RECQL POFUT1 STT3A

9.98e-0421272433462405
Pubmed

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.

MBTD1 TRRAP

1.04e-032372231281901
Pubmed

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

MBTD1 TRRAP

1.04e-032372214966270
Pubmed

Genome-wide association study identifies five new schizophrenia loci.

CCDC68 STT3A

1.04e-032372221926974
Pubmed

Affinity purification strategies for proteomic analysis of transcription factor complexes.

STAG1 PDCD11 U2AF2

1.09e-039772323937658
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

STEEP1 RNF213 RECQL PRKDC MAU2 ECPAS TRRAP CDC45

1.17e-03101472832416067
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

KIAA0825 DNM3 MAU2

1.19e-0310072310048485
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

RNF213 TRRAP CDC45

1.33e-0310472331240132
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

NUP107 STAG1 PDCD11

1.33e-0310472326167872
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

MBTD1 TMTC3 NUP107 STEEP1 PDCD11 U2AF2 PRKDC MAU2 TRRAP

1.38e-03129472930804502
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

NUP107 RECQL PRKDC STT3A

1.50e-0323772429564676
Pubmed

The full-ORF clone resource of the German cDNA Consortium.

RNF213 ARMCX4

1.54e-032872217974005
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

INTU NUP107 VPS4A TTC21A SEC23IP EXOC6B BBIP1 ZNRF2 DYRK2

1.59e-03132172927173435
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

FBXO38 STAG1 STEEP1 MASTL RECQL TRRAP

1.64e-0360872636089195
Pubmed

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

PRKDC TRRAP

1.65e-032972220371770
Pubmed

Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.

BRAF PRKDC

1.77e-033072234017080
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NUP107 VPS4A PDCD11 U2AF2 RECQL PRKDC RRM2 TRRAP CDC45

1.87e-03135372929467282
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MBTD1 RINT1 NUP107 STAG1 RECQL ECPAS TRRAP

1.98e-0385772725609649
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

PRKDC ECPAS TRRAP

2.01e-0312072327320910
Pubmed

FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.

FBXO38 RRM2

2.01e-033272235813202
ToppCell368C-Fibroblasts-Fibroblast-E|368C / Donor, Lineage, Cell class and subclass (all cells)

IL17RE PRELP RNF217 VWA5B1 CDC45

6.55e-06162725e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell368C-Fibroblasts-Fibroblast-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

IL17RE PRELP RNF217 VWA5B1 CDC45

6.55e-06162725ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYH6 ROR1 EXOC6B UNC13D RYR2

1.35e-051887256d249fe92d51a19da19ec14bb2262d394255d577
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRELP ROR1 FXYD6 BICC1 RYR2

1.35e-051887253177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRELP ROR1 FXYD6 BICC1 RYR2

1.38e-0518972545e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRELP ROR1 FXYD6 BICC1 RYR2

1.45e-05191725b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRELP ROR1 FXYD6 BICC1 STT3A

1.65e-05196725b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRELP ROR1 FXYD6 BICC1 STT3A

1.65e-05196725787c6cd92035e0b1108c2c086c42a229016e476b
DiseaseAdenocarcinoma of large intestine

BRAF ROR1 DCLK3 PRKDC TRRAP

3.13e-0696695C1319315
DiseaseSquamous cell carcinoma of lung

GUCY2F DCLK3 PRKDC

5.78e-0532693C0149782
DiseaseLDL cholesterol change measurement, response to simvastatin, response to fenofibrate

MAU2 BICC1

1.50e-048692EFO_0007804, GO_1901557, GO_1903491
Diseasecheekbone morphology measurement

ZNRF2 RYR2

3.50e-0412692EFO_0007847
DiseaseCOVID-19, osteoarthritis

CCR3 TAC4

9.96e-0420692MONDO_0005178, MONDO_0100096
DiseaseRespiratory Hypersensitivity

SLC39A4 CCR3

1.21e-0322692C0035228
DiseaseAdenocarcinoma of lung (disorder)

BRAF GUCY2F PRKDC RRM2

1.40e-03206694C0152013
Diseaseneurotic disorder

STAG1 CCDC68 DNM3

1.73e-03101693EFO_0004257
DiseaseBreast Cancer, Familial

RINT1 RECQL

2.25e-0330692C0346153
Diseaseresponse to tenofovir, creatinine clearance measurement

BRAF OR5AP2 RYR2

2.32e-03112693EFO_0007934, EFO_0009279
Diseasepancreatic cancer (is_implicated_in)

BRAF RECQL RRM2

2.32e-03112693DOID:1793 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
EIALPIEACVMMLLS

BARGIN

296

Q6ZT62
LKKALMMRGLIPECC

BRAF

181

P15056
KLMDKISLVMECIPL

CCDC171

911

Q6TFL3
EKLPIPMIAKNLMCE

MASTL

521

Q96GX5
MDPSCCSLDLLMKKI

CCDC68

81

Q9H2F9
MELVLVFLCSLLAPM

FXYD6

1

Q9H0Q3
CLPLVLMFDMKEEIE

BICC1

351

Q9H694
ANMDPRDLEKLICMI

ARMCX4

2036

Q5H9R4
MVLLRKLCLPMLCFL

NUP107

846

P57740
VCFTLVMVPKMLVDL

OR10A7

71

Q8NGE5
MEKLDTMLPLALACR

KIAA0825

491

Q8IV33
MKLEAVDLMEPRLIC

MBTD1

496

Q05BQ5
QMVMALTLRCPLKLE

IL17RE

286

Q8NFR9
EPDAALMIMDLCKAL

DCLK3

451

Q9C098
CIRDLIPKTIMHLMI

DNM3

676

Q9UQ16
KLLVDMDPRMLVSCI

ENOSF1

136

Q7L5Y1
IAALLPCLLDKGMMS

ECPAS

1251

Q5VYK3
VDKLMLCLPVLEMYS

EXOC6B

131

Q9Y2D4
LALMDLMYLCVTVPK

OR2T34

71

Q8NGX1
LALMDLMYLCVTVPK

OR2T3

71

Q8NH03
PCLMTIAILMILAQK

DEFB116

6

Q30KQ4
MIVLIKIDLCLHTPM

OR5AP2

51

Q8NGF4
LMGLCKIAESVEMLI

SLC2A14

131

Q8TDB8
LVADLIMTLMLPFKI

P2RY13

86

Q9BPV8
LTLPLEIKMELDMAL

INTU

476

Q9ULD6
PLQDIMCMECLSRKL

FBXO38

46

Q6PIJ6
VIGPKICLEDKMLMS

FAM3A

81

P98173
CKLLPLVMAAPLSME

CDC45

486

O75419
ALLLFLLMCEIPMVE

C1QTNF6

31

Q9BXI9
LLMCEIPMVELTFDR

C1QTNF6

36

Q9BXI9
LRMTIFCLVLPLLVM

CCR3

201

P51677
FVEDIMTMVLCKPKL

BBIP1

41

A8MTZ0
PAFAMMVCLTLLIAL

GUCY2F

466

P51841
KMVLECLLNLMQRDP

HEATR4

761

Q86WZ0
DKELCMSLMAICRPL

CUTC

126

Q9NTM9
PARTMKVVLMLLFIC

SEC22C

246

Q9BRL7
ALMQLEKLKMLDCSP

MAU2

316

Q9Y6X3
MKLPEPVKLQMCLLL

RYR2

1896

Q92736
LACMIELLGMPSQKL

DYRK2

431

Q92630
DISMDILMLLLLLCV

PKD1L1

2286

Q8TDX9
APLTMTMCLPDLKEI

POFUT1

276

Q9H488
QMVLVLDCQLEKLPM

STEEP1

36

Q9H5V9
MIPDAECLKIMCEIL

HARS2

186

P49590
MEILLLMVDDSPLIV

RABGGTA

271

Q92696
ALCDMLPAMLKVRDP

SLC39A4

601

Q6P5W5
LMLVLAPVMCILSGI

STT3A

406

P46977
IPLDLMMCFRLLQSV

PRELP

366

P51888
VPLMVLMCRVCLEDK

RNF217

256

Q8TC41
LMCTVDDLKEMGIPL

SEC23IP

676

Q9Y6Y8
CIDLIEKPMGIMSIL

MYH6

521

P13533
DICILTLAMMIAGIP

SPATA25

151

Q9BR10
CMLISIQALLKGPLM

TM4SF20

101

Q53R12
VICPLISLMEDQLMV

RECQL

136

P46063
PMILMRLKLPNCEDL

ROR1

271

Q01973
NVFMMVVCIELKIPL

RNF213

2751

Q63HN8
RVLLCDPEAKKLMMT

PDCD11

506

Q14690
EMDLHLVMCLTKPRI

ZNRF2

171

Q8NHG8
MLMVLEALVPCYLQK

UNC80

2366

Q8N2C7
LMMLVLEKLATDIPC

RINT1

376

Q6NUQ1
EALPVKLIGMNCTLM

RRM2

306

P31350
TMMKLVLEDPLLVSL

PLEKHG4B

391

Q96PX9
MLLKEYRICMPLTVD

PITPNC1

1

Q9UKF7
PVKEQAFMLLCDLLM

STAG1

786

Q8WVM7
PSMMNDVKCLLLLAK

TTC21A

831

Q8NDW8
PMLLELMTEVLCREQ

PRKDC

1756

P78527
PCVPKDLLMMSEFVL

UBR3

196

Q6ZT12
EVLCLMNMVLPEELL

U2AF2

376

P26368
KTVLMALCLMALPFI

TMTC3

346

Q6ZXV5
MLPCLALLLLMELSV

TAC4

1

Q86UU9
LCYDPEMKMLLSGIL

WDR87

116

Q6ZQQ6
GMDPLVLIDAIAICM

TRRAP

1086

Q9Y4A5
ILPLMKFLEVELCYM

UNC13D

791

Q70J99
KDAMLVALKSLMPAC

VWA5B1

381

Q5TIE3
KLLEPVVCMSDMLRS

VPS4A

396

Q9UN37