Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfucose binding

CLEC17A ASGR1 ACR

3.55e-068813GO:0042806
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS12 TMPRSS15 KLK10 OVCH2 ACR ADAM7 CFI ADAM8 SPPL2C

6.07e-05430819GO:0004175
GeneOntologyMolecularFunctionserine-type endopeptidase activity

TMPRSS15 KLK10 OVCH2 ACR CFI ADAM8

1.23e-04190816GO:0004252
GeneOntologyMolecularFunctionD-mannose binding

CLEC17A ASGR1 ACR

1.75e-0427813GO:0005537
GeneOntologyMolecularFunctionserine-type peptidase activity

TMPRSS15 KLK10 OVCH2 ACR CFI ADAM8

1.96e-04207816GO:0008236
GeneOntologyMolecularFunctioncalcium ion binding

EYS CELSR1 EFCAB6 HMCN1 DLL4 CUBN ADAM8 LTBP4 SVEP1 NOTCH2 NOTCH4

2.13e-047498111GO:0005509
GeneOntologyMolecularFunctionserine hydrolase activity

TMPRSS15 KLK10 OVCH2 ACR CFI ADAM8

2.23e-04212816GO:0017171
GeneOntologyMolecularFunctionGPI-linked ephrin receptor activity

EPHA4 EPHA8

3.37e-047812GO:0005004
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

EGFR LTBP4 EPHA4 EPHA8

3.96e-0485814GO:0019199
GeneOntologyMolecularFunctionfrizzled binding

RSPO3 WNT5A WNT6

6.59e-0442813GO:0005109
GeneOntologyMolecularFunctionintegrin binding

VWF EGFR ADAM8 LTBP4 SVEP1

7.31e-04175815GO:0005178
GeneOntologyMolecularFunctionpeptidase activity

ADAMTS12 TMPRSS15 KLK10 OVCH2 ACR ADAM7 CFI ADAM8 SPPL2C

1.31e-03654819GO:0008233
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHA4 EPHA8

1.65e-0315812GO:0005005
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

ADAMTS12 RSPO3 SLC39A12 CELSR1 EGFR DLL4 WNT5A WNT6 SEMA5A SPAG6 NOTCH2 NOTCH4 EPHA4

9.43e-076198213GO:0002009
GeneOntologyBiologicalProcesstissue morphogenesis

ADAMTS12 RSPO3 SLC39A12 CELSR1 EGFR DLL4 WNT5A WNT6 SEMA5A ADAM8 SPAG6 NOTCH2 NOTCH4 EPHA4

1.39e-067508214GO:0048729
GeneOntologyBiologicalProcessepithelial tube morphogenesis

ADAMTS12 SLC39A12 CELSR1 DLL4 WNT5A WNT6 SEMA5A NOTCH2 NOTCH4 EPHA4

6.51e-064218210GO:0060562
GeneOntologyBiologicalProcessmorphogenesis of a branching epithelium

RSPO3 CELSR1 DLL4 WNT5A WNT6 SEMA5A NOTCH4

4.31e-05236827GO:0061138
GeneOntologyBiologicalProcesspositive regulation of non-canonical Wnt signaling pathway

RSPO3 WNT5A ANKRD6

4.73e-0518823GO:2000052
GeneOntologyBiologicalProcessepithelium development

ADAMTS12 RSPO3 KRT2 SLC39A12 CELSR1 EGFR DLL4 WNT5A WNT6 ADAM7 SEMA5A PLAUR NSUN2 SPAG6 NOTCH2 NOTCH4 EPHA4

5.45e-0514698217GO:0060429
GeneOntologyBiologicalProcessregulation of establishment of planar polarity

CELSR1 WNT5A SPAG6

5.60e-0519823GO:0090175
GeneOntologyBiologicalProcesspositive regulation of T cell apoptotic process

WNT5A SIGLEC1 ADAM8

5.60e-0519823GO:0070234
GeneOntologyBiologicalProcessregulation of miRNA metabolic process

EGFR DROSHA RC3H1 SREBF2 NOTCH2

5.66e-05103825GO:2000628
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

RSPO3 CELSR1 WNT5A ANKRD6

6.78e-0555824GO:0060071
GeneOntologyBiologicalProcessmorphogenesis of a branching structure

RSPO3 CELSR1 DLL4 WNT5A WNT6 SEMA5A NOTCH4

7.55e-05258827GO:0001763
GeneOntologyBiologicalProcessmiRNA metabolic process

EGFR DROSHA RC3H1 SREBF2 NOTCH2

1.12e-04119825GO:0010586
GeneOntologyBiologicalProcesspositive regulation of lymphocyte apoptotic process

WNT5A SIGLEC1 ADAM8

1.15e-0424823GO:0070230
GeneOntologyBiologicalProcesstube morphogenesis

ADAMTS12 RSPO3 SLC39A12 CELSR1 EGFR DLL4 WNT5A WNT6 SEMA5A C6 ADAM8 NOTCH2 NOTCH4 EPHA4

1.29e-0411258214GO:0035239
GeneOntologyBiologicalProcessbranching morphogenesis of an epithelial tube

CELSR1 DLL4 WNT5A WNT6 SEMA5A NOTCH4

1.39e-04198826GO:0048754
GeneOntologyBiologicalProcessneuron projection fasciculation

WNT5A SEMA5A EPHA4

1.85e-0428823GO:0106030
GeneOntologyBiologicalProcessaxonal fasciculation

WNT5A SEMA5A EPHA4

1.85e-0428823GO:0007413
GeneOntologyBiologicalProcesspositive regulation of thymocyte apoptotic process

WNT5A ADAM8

2.32e-046822GO:0070245
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

RSPO3 CELSR1 WNT5A ANKRD6

2.52e-0477824GO:0035567
GeneOntologyBiologicalProcessregulation of non-canonical Wnt signaling pathway

RSPO3 WNT5A ANKRD6

2.76e-0432823GO:2000050
GeneOntologyBiologicalProcesspositive regulation of protein kinase C activity

EGFR WNT5A

3.24e-047822GO:1900020
GeneOntologyBiologicalProcessregulation of protein kinase C activity

EGFR WNT5A

3.24e-047822GO:1900019
GeneOntologyBiologicalProcesscardiac atrium morphogenesis

DLL4 WNT5A NOTCH2

3.62e-0435823GO:0003209
GeneOntologyBiologicalProcesssubstrate-dependent cell migration

ADAM8 SPAG6 EPHA8

3.62e-0435823GO:0006929
GeneOntologyBiologicalProcesstube development

ADAMTS12 RSPO3 SLC39A12 CELSR1 EGFR DLL4 WNT5A WNT6 ADAM7 SEMA5A C6 ADAM8 NOTCH2 NOTCH4 EPHA4

3.75e-0414028215GO:0035295
GeneOntologyBiologicalProcesscell fate commitment

HOXC10 DLL4 WNT5A WNT6 ISL2 NOTCH2 NOTCH4

3.96e-04338827GO:0045165
GeneOntologyBiologicalProcesspositive regulation of Wnt signaling pathway

RSPO3 EGFR WNT5A SEMA5A ANKRD6

4.20e-04158825GO:0030177
GeneOntologyBiologicalProcesspositive regulation of leukocyte apoptotic process

WNT5A SIGLEC1 ADAM8

4.62e-0438823GO:2000108
GeneOntologyBiologicalProcesspericardium morphogenesis

DLL4 WNT5A

5.52e-049822GO:0003344
GeneOntologyCellularComponentextracellular matrix

ADAMTS12 EYS FCGBP VWF HMCN1 WNT5A WNT6 LTBP4 MUC6 SVEP1

2.67e-046568310GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS12 EYS FCGBP VWF HMCN1 WNT5A WNT6 LTBP4 MUC6 SVEP1

2.74e-046588310GO:0030312
GeneOntologyCellularComponentcell surface

VWF EGFR CLEC17A ASGR1 WNT5A WNT6 PLAUR CUBN ADAM8 VWDE NOTCH2 NOTCH4 EPHA4

4.16e-0411118313GO:0009986
DomainEGF

RSPO3 EYS CELSR1 FCGBP MALRD1 HMCN1 DLL4 CUBN ADAM8 LTBP4 VWDE SVEP1 NOTCH2 NOTCH4

1.46e-122358114SM00181
DomainEGF-like_dom

EYS CELSR1 FCGBP MALRD1 HMCN1 DLL4 C6 CUBN ADAM8 LTBP4 VWDE SVEP1 NOTCH2 NOTCH4

3.21e-122498114IPR000742
DomainEGF-like_CS

EYS CELSR1 MALRD1 HMCN1 DLL4 C6 CUBN ADAM8 LTBP4 VWDE SVEP1 NOTCH2 NOTCH4 EPHA8

6.05e-122618114IPR013032
DomainEGF_2

EYS CELSR1 MALRD1 HMCN1 DLL4 C6 CUBN ADAM8 LTBP4 VWDE SVEP1 NOTCH2 NOTCH4 EPHA8

7.43e-122658114PS01186
DomainEGF_3

EYS CELSR1 MALRD1 HMCN1 DLL4 C6 CUBN ADAM8 LTBP4 VWDE SVEP1 NOTCH2 NOTCH4

2.50e-112358113PS50026
DomainEGF_1

EYS CELSR1 MALRD1 HMCN1 DLL4 C6 CUBN ADAM8 LTBP4 VWDE SVEP1 NOTCH2 NOTCH4

6.95e-112558113PS00022
DomainGrowth_fac_rcpt_

RSPO3 EYS CELSR1 HMCN1 EGFR DLL4 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

7.10e-111568111IPR009030
DomainASX_HYDROXYL

EYS CELSR1 HMCN1 DLL4 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

4.75e-10100819PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

EYS CELSR1 HMCN1 DLL4 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

8.04e-10106819IPR000152
DomainEGF_CA

EYS CELSR1 HMCN1 DLL4 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

2.82e-09122819SM00179
DomainEGF-like_Ca-bd_dom

EYS CELSR1 HMCN1 DLL4 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

3.26e-09124819IPR001881
DomainEGF

EYS CELSR1 MALRD1 HMCN1 DLL4 CUBN SVEP1 NOTCH2 NOTCH4

3.76e-09126819PF00008
DomainEGF_Ca-bd_CS

EYS HMCN1 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

2.08e-0797817IPR018097
DomainEGF_CA

EYS HMCN1 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

2.39e-0799817PS01187
DomainVWD

FCGBP VWF MUC6 VWDE

5.74e-0716814SM00216
DomainVWF_type-D

FCGBP VWF MUC6 VWDE

5.74e-0716814IPR001846
DomainVWFD

FCGBP VWF MUC6 VWDE

5.74e-0716814PS51233
DomainVWD

FCGBP VWF MUC6 VWDE

5.74e-0716814PF00094
DomainEGF_CA

HMCN1 CUBN LTBP4 SVEP1 NOTCH2 NOTCH4

1.97e-0686816PF07645
DomainhEGF

EYS SVEP1 NOTCH2 NOTCH4

6.21e-0628814PF12661
DomainTSP_1

ADAMTS12 RSPO3 HMCN1 SEMA5A C6

7.81e-0663815PF00090
DomainTSP1

ADAMTS12 RSPO3 HMCN1 SEMA5A C6

9.12e-0665815SM00209
DomainTSP1_rpt

ADAMTS12 RSPO3 HMCN1 SEMA5A C6

9.12e-0665815IPR000884
DomainTSP1

ADAMTS12 RSPO3 HMCN1 SEMA5A C6

9.12e-0665815PS50092
DomainTIL

FCGBP VWF MUC6

1.68e-0512813PF01826
DomainC8

FCGBP VWF MUC6

1.68e-0512813PF08742
DomainUnchr_dom_Cys-rich

FCGBP VWF MUC6

2.18e-0513813IPR014853
DomainC8

FCGBP VWF MUC6

2.18e-0513813SM00832
DomainLDLR_class-A_CS

TMPRSS15 MALRD1 C6 CFI

2.66e-0540814IPR023415
DomainTIL_dom

FCGBP VWF MUC6

2.76e-0514813IPR002919
DomainLdl_recept_a

TMPRSS15 MALRD1 C6 CFI

4.27e-0545814PF00057
DomainLDLRA_1

TMPRSS15 MALRD1 C6 CFI

5.52e-0548814PS01209
DomainLDLRA_2

TMPRSS15 MALRD1 C6 CFI

6.00e-0549814PS50068
DomainLDrepeatLR_classA_rpt

TMPRSS15 MALRD1 C6 CFI

6.00e-0549814IPR002172
DomainLDLa

TMPRSS15 MALRD1 C6 CFI

6.00e-0549814SM00192
DomainVWC_out

FCGBP VWF MUC6

7.24e-0519813SM00215
DomainTRYPSIN_SER

TMPRSS15 KLK10 OVCH2 ACR CFI

9.74e-05106815PS00135
DomainTRYPSIN_HIS

TMPRSS15 KLK10 OVCH2 ACR CFI

1.02e-04107815PS00134
DomainFacI_MAC

C6 CFI

1.11e-044812IPR003884
DomainNotch

NOTCH2 NOTCH4

1.11e-044812IPR008297
DomainNODP

NOTCH2 NOTCH4

1.11e-044812PF07684
DomainNotch_NODP_dom

NOTCH2 NOTCH4

1.11e-044812IPR011656
DomainNotch_NOD_dom

NOTCH2 NOTCH4

1.11e-044812IPR010660
DomainNOD

NOTCH2 NOTCH4

1.11e-044812PF06816
DomainFIMAC

C6 CFI

1.11e-044812SM00057
DomainNOD

NOTCH2 NOTCH4

1.11e-044812SM01338
DomainNODP

NOTCH2 NOTCH4

1.11e-044812SM01339
DomainPeptidase_S1A

TMPRSS15 KLK10 OVCH2 ACR CFI

1.32e-04113815IPR001314
DomainTRYPSIN_DOM

TMPRSS15 KLK10 OVCH2 ACR CFI

1.43e-04115815PS50240
DomainTryp_SPc

TMPRSS15 KLK10 OVCH2 ACR CFI

1.55e-04117815SM00020
DomainEphrin_rec_like

SVEP1 EPHA4 EPHA8

1.69e-0425813SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

SVEP1 EPHA4 EPHA8

1.69e-0425813IPR011641
DomainTrypsin

TMPRSS15 KLK10 OVCH2 ACR CFI

1.82e-04121815PF00089
DomainTrypsin_dom

TMPRSS15 KLK10 OVCH2 ACR CFI

1.82e-04121815IPR001254
DomainLNR

NOTCH2 NOTCH4

1.84e-045812PS50258
DomainPeptidase_S1_PA

TMPRSS15 KLK10 OVCH2 ACR CFI

1.96e-04123815IPR009003
DomainNotch_dom

NOTCH2 NOTCH4

3.85e-047812IPR000800
DomainNotch

NOTCH2 NOTCH4

3.85e-047812PF00066
DomainNL

NOTCH2 NOTCH4

3.85e-047812SM00004
DomainPeptidase_M12B_N

ADAMTS12 ADAM7 ADAM8

6.42e-0439813IPR002870
DomainPep_M12B_propep

ADAMTS12 ADAM7 ADAM8

6.42e-0439813PF01562
DomainDISINTEGRIN_1

ADAMTS12 ADAM7 ADAM8

6.92e-0440813PS00427
DomainReprolysin

ADAMTS12 ADAM7 ADAM8

6.92e-0440813PF01421
DomainADAM_MEPRO

ADAMTS12 ADAM7 ADAM8

6.92e-0440813PS50215
DomainDISINTEGRIN_2

ADAMTS12 ADAM7 ADAM8

6.92e-0440813PS50214
DomainPeptidase_M12B

ADAMTS12 ADAM7 ADAM8

6.92e-0440813IPR001590
DomainDisintegrin_dom

ADAMTS12 ADAM7 ADAM8

7.44e-0441813IPR001762
DomainANK

POTEB3 POTED ANKRD6 POTEC NOTCH2 NOTCH4

7.76e-04251816SM00248
DomainVWF_dom

FCGBP VWF MUC6

7.99e-0442813IPR001007
DomainANK_REPEAT

POTEB3 POTED ANKRD6 POTEC NOTCH2 NOTCH4

8.09e-04253816PS50088
DomainANK_REP_REGION

POTEB3 POTED ANKRD6 POTEC NOTCH2 NOTCH4

8.26e-04254816PS50297
DomainAnkyrin_rpt

POTEB3 POTED ANKRD6 POTEC NOTCH2 NOTCH4

9.70e-04262816IPR002110
Domain-

HMCN1 SVEP1

9.96e-04118122.40.155.10
DomainGFP-like

HMCN1 SVEP1

9.96e-0411812IPR023413
Domain-

TMPRSS15 MALRD1 CFI

1.04e-03468134.10.400.10
DomainTRYPSIN_HIS

TMPRSS15 KLK10 ACR CFI

1.05e-03103814IPR018114
DomainCUB

TMPRSS15 OVCH2 CUBN

1.25e-0349813PF00431
DomainKAZAL_2

SLCO1C1 C6 CFI

1.33e-0350813PS51465
DomainCUB

TMPRSS15 OVCH2 CUBN

1.33e-0350813SM00042
DomainKazal_dom

SLCO1C1 C6 CFI

1.41e-0351813IPR002350
DomainCUB

TMPRSS15 OVCH2 CUBN

1.57e-0353813PS01180
DomainRECEPTOR_TYR_KIN_V_2

EPHA4 EPHA8

1.63e-0314812PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHA4 EPHA8

1.63e-0314812PS00790
DomainEph_TM

EPHA4 EPHA8

1.63e-0314812IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHA4 EPHA8

1.63e-0314812IPR001426
DomainEPH_lbd

EPHA4 EPHA8

1.63e-0314812SM00615
DomainEphrin_lbd

EPHA4 EPHA8

1.63e-0314812PF01404
DomainEphA2_TM

EPHA4 EPHA8

1.63e-0314812PF14575
DomainTyr_kinase_ephrin_rcpt

EPHA4 EPHA8

1.63e-0314812IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHA4 EPHA8

1.63e-0314812IPR001090
DomainEPH_LBD

EPHA4 EPHA8

1.63e-0314812PS51550
DomainCUB_dom

TMPRSS15 OVCH2 CUBN

1.94e-0357813IPR000859
DomainDisintegrin_CS

ADAM7 ADAM8

2.14e-0316812IPR018358
DomainEGF_extracell

DLL4 ADAM8 SVEP1

2.25e-0360813IPR013111
DomainEGF_2

DLL4 ADAM8 SVEP1

2.25e-0360813PF07974
DomainMAM

TMPRSS15 MALRD1

2.42e-0317812SM00137
DomainAnk_2

POTEB3 ANKRD6 POTEC NOTCH2 NOTCH4

2.43e-03215815PF12796
DomainConA-like_dom

EYS TMPRSS15 CELSR1 MALRD1 SVEP1

2.63e-03219815IPR013320
DomainMAM

TMPRSS15 MALRD1

2.72e-0318812PF00629
DomainMAM_dom

TMPRSS15 MALRD1

2.72e-0318812IPR000998
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS12 SEMA5A MUC6 NOTCH2 NOTCH4

5.92e-0668545M27303
PathwayKEGG_COMPLEMENT_AND_COAGULATION_CASCADES

VWF PLAUR C6 CFI BDKRB2

6.37e-0669545M16894
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH2 NOTCH4

1.48e-0513543M47423
PathwayWP_BREAST_CANCER_PATHWAY

EGFR DLL4 WNT5A WNT6 NOTCH2 NOTCH4

2.58e-05154546M39739
PathwayWP_COMPLEMENT_AND_COAGULATION_CASCADES

VWF PLAUR C6 CFI

7.00e-0558544M39649
PathwayWP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES

VWF PLAUR C6 CFI

7.49e-0559544M48343
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

DLL4 WNT5A WNT6 NOTCH2 NOTCH4

8.60e-05118545M39852
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

EGFR NOTCH2 NOTCH4

1.02e-0424543M11190
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH2 NOTCH4

1.43e-045542M27411
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL4 NOTCH2 NOTCH4

1.46e-0427543M39545
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS12 SEMA5A MUC6 NOTCH2 NOTCH4

2.12e-04143545M27275
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH2 NOTCH4

2.14e-046542M27068
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

EGFR DLL4 NOTCH2 NOTCH4

2.70e-0482544MM15922
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

DLL4 WNT5A WNT6 NOTCH2 NOTCH4

3.68e-04161545M39770
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS12 SEMA5A CUBN MUC6 NOTCH2 NOTCH4

3.71e-04250546M27554
PathwayREACTOME_SIGNALING_BY_NOTCH

EGFR DLL4 NOTCH4

4.40e-0439543MM14604
PathwayWP_CANCER_PATHWAYS

EGFR DLL4 WNT5A WNT6 BDKRB2 RXRB NOTCH2 NOTCH4

6.42e-04507548M48302
PathwayWP_NOTCH_SIGNALING_WP268

DLL4 NOTCH2 NOTCH4

6.73e-0445543M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH2 NOTCH4

7.18e-0446543MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH2 NOTCH4

7.65e-0447543M7946
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH2 NOTCH4

7.75e-0411542M47865
PathwayREACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 NOTCH4

7.75e-0411542M27882
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH2 NOTCH4

9.27e-0412542M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH2 NOTCH4

9.27e-0412542M47533
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH2 NOTCH4

1.09e-0313542M47534
PathwayPID_NOTCH_PATHWAY

DLL4 NOTCH2 NOTCH4

1.48e-0359543M17
PathwayWP_22Q112_COPY_NUMBER_VARIATION_SYNDROME

VWF EGFR DROSHA SREBF2

1.53e-03130544M39787
PathwayWP_NOTCH_SIGNALING_WP61

DLL4 NOTCH2 NOTCH4

1.63e-0361543M39540
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

DLL4 NOTCH4

1.67e-0316542M47424
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

DLL4 NOTCH2 NOTCH4

1.31e-07583321726900
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

DLL4 NOTCH2 NOTCH4

1.31e-07583323675950
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

DLL4 CHAT NOTCH2 NOTCH4

1.75e-072183428656980
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB3 POTED POTEC

7.28e-07883312475935
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS12 HMCN1 SEMA5A C6 CUBN

1.04e-067583520637190
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL4 NOTCH2 NOTCH4

1.09e-06983316245338
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL4 NOTCH2 NOTCH4

1.55e-061083323665443
Pubmed

Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.

WNT5A ISL2 EPHA4

2.13e-061183319210786
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

NOTCH2 NOTCH4 EPHA4

2.13e-06118339187150
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

EGFR WNT5A RC3H1 ISL2 UPF1 NOTCH2 EPHA4 EPHA8

2.35e-0635883832460013
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL4 NOTCH2 NOTCH4

2.84e-061283315465494
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL4 NOTCH2 NOTCH4

3.68e-061383311578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

VWF NOTCH2 NOTCH4

3.68e-061383320558824
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL4 NOTCH2 NOTCH4

4.68e-061483314757642
Pubmed

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.

DLL4 ADAM8 NOTCH2 NOTCH4

5.42e-064883435247391
Pubmed

Notch receptors and hematopoiesis.

NOTCH2 NOTCH4

5.63e-06283211532344
Pubmed

Bradykinin B2 receptor activates extracellular signal-regulated protein kinase in mIMCD-3 cells via epidermal growth factor receptor transactivation.

EGFR BDKRB2

5.63e-06283212604671
Pubmed

EGFR/uPAR interaction as druggable target to overcome vemurafenib acquired resistance in melanoma cells.

EGFR PLAUR

5.63e-06283230611716
Pubmed

Rare genetic variants in Tunisian Jewish patients suffering from age-related macular degeneration.

HMCN1 CFI

5.63e-06283225986072
Pubmed

Notch signaling in primary endothelial cells.

DLL4 NOTCH4

5.63e-06283212814948
Pubmed

[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer].

EGFR ADAM8

5.63e-06283218710625
Pubmed

Breast cancer stem cells: something out of notching?

DLL4 NOTCH4

5.63e-06283221045140
Pubmed

Mouse strain-specific patterns of mammary epithelial ductal side branching are elicited by stromal factors.

WNT5A WNT6

5.63e-06283212203726
Pubmed

Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion.

EGFR PLAUR

5.63e-06283225837250
Pubmed

Asialoglycoprotein receptor promotes cancer metastasis by activating the EGFR-ERK pathway.

EGFR ASGR1

5.63e-06283221868757
Pubmed

A relative signalling model for the formation of a topographic neural map.

ISL2 EPHA4

5.63e-06283215483613
Pubmed

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

EGFR PLAUR

5.63e-06283228193671
Pubmed

DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling.

EGFR PLAUR

5.63e-06283215302576
Pubmed

notch2, notch4 gene polymorphisms in psoriasis vulgaris.

NOTCH2 NOTCH4

5.63e-06283223587900
Pubmed

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.

EGFR PLAUR

5.63e-06283221896743
Pubmed

Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.

NOTCH2 NOTCH4

5.63e-06283220643108
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL4 NOTCH2 NOTCH4

5.84e-061583312971992
Pubmed

Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity.

HOXC10 ISL2 SEMA5A CHAT

5.89e-064983435315772
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL4 NOTCH2 NOTCH4

7.18e-061683312617809
Pubmed

Molecular genetic studies of Wnt signaling in the mouse.

WNT5A WNT6 ANKRD6

7.18e-061683310585256
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL4 NOTCH2 NOTCH4

7.18e-061683317273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

DLL4 NOTCH2 NOTCH4

8.70e-061783318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

DLL4 NOTCH2 NOTCH4

8.70e-061783315821257
Pubmed

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking.

DLL4 NOTCH2 NOTCH4

8.70e-061783339315665
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

DLL4 NOTCH2 NOTCH4

1.04e-051883318093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

DLL4 NOTCH2 NOTCH4

1.04e-051883315689374
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

DLL4 NOTCH2 NOTCH4

1.24e-051983316518823
Pubmed

Differential Islet-1 expression among lumbosacral spinal motor neurons in prenatal mouse.

ISL2 CHAT

1.69e-05383219236857
Pubmed

Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping.

ISL2 EPHA4

1.69e-05383221753007
Pubmed

Microsatellite polymorphisms in the EGFR, NOTCH4 and E2F4 genes and their association with breast cancer risk.

EGFR NOTCH4

1.69e-05383223015403
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH2 NOTCH4

1.69e-05383211836628
Pubmed

Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.

ADAM7 ADAM8

1.69e-0538328163572
Pubmed

KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy.

DLL4 NOTCH2

1.69e-05383238973459
Pubmed

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.

VWF ASGR1

1.69e-05383229282218
Pubmed

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.

NOTCH2 NOTCH4

1.69e-05383211823422
Pubmed

Islet-1 expression in thoracic spinal motor neurons in prenatal mouse.

ISL2 CHAT

1.69e-05383221651972
Pubmed

Notch signaling: cell fate control and signal integration in development.

NOTCH2 NOTCH4

1.69e-05383210221902
Pubmed

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

DLL4 NOTCH2

1.69e-05383228572448
Pubmed

Regnase-1 and Roquin regulate inflammatory mRNAs.

RC3H1 UPF1

1.69e-05383226255671
Pubmed

The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study.

DLL4 NOTCH4

1.69e-05383226472724
Pubmed

Helicobacter pylori Infection of Gastric Epithelial Cells Affects NOTCH Pathway In Vitro.

DLL4 NOTCH2

1.69e-05383227073072
Pubmed

D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR.

EGFR PLAUR

1.69e-05383229184982
Pubmed

Factor XII and uPAR upregulate neutrophil functions to influence wound healing.

PLAUR BDKRB2

1.69e-05383229376892
Pubmed

O-Fucose and Fringe-modified NOTCH1 extracellular domain fragments as decoys to release niche-lodged hematopoietic progenitor cells.

DLL4 NOTCH2

1.69e-05383233351914
Pubmed

m6A‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling.

HOXC10 EGFR

1.69e-05383238063205
Pubmed

Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system.

CHAT BDKRB2

1.69e-05383223777652
Pubmed

Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.

DLL4 NOTCH4

1.69e-05383222066479
Pubmed

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways.

EGFR BDKRB2

1.69e-05383226360782
Pubmed

Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1G93A ALS mouse model.

CHAT EPHA4

1.69e-05383230061574
Pubmed

[Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].

PTOV1 EPHA4

1.69e-05383227804940
Pubmed

The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.

DLL4 NOTCH4

1.69e-05383216951162
Pubmed

Stem cell function and stress response are controlled by protein synthesis.

EGFR NSUN2

1.69e-05383227306184
Pubmed

Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.

ISL2 SEMA5A CHAT

1.95e-052283336549270
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

DLL4 NOTCH2 NOTCH4

2.24e-052383314701881
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

DLL4 NOTCH2 NOTCH4

2.24e-052383336239412
Pubmed

Primary cilia in murine palatal rugae development.

CELSR1 WNT5A WNT6

2.24e-052383331226309
Pubmed

Loss of Gata5 in mice leads to bicuspid aortic valve.

DLL4 NOTCH2 NOTCH4

2.56e-052483321633169
Pubmed

Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2.

ISL2 SEMA5A CHAT

2.90e-052583337869988
Pubmed

The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.

ISL2 NOTCH2 NOTCH4

2.90e-052583321786021
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

WNT5A WNT6 SEMA5A CHAT RXRB NOTCH2

3.16e-0525183629031500
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

DLL4 NOTCH2 NOTCH4

3.27e-052683319369401
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH2 NOTCH4

3.37e-05483224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH2 NOTCH4

3.37e-05483220069356
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH2 NOTCH4

3.37e-05483219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH2 NOTCH4

3.37e-05483228669409
Pubmed

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma.

EGFR PLAUR

3.37e-05483222984561
Pubmed

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.

RC3H1 UPF1

3.37e-05483226000482
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH2 NOTCH4

3.37e-05483211401408
Pubmed

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

DLL4 NOTCH2

3.37e-05483228319044
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH2 NOTCH4

3.37e-0548328898100
Pubmed

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.

DLL4 NOTCH4

3.37e-05483236376768
Pubmed

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

NOTCH2 NOTCH4

3.37e-05483223444212
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH2 NOTCH4

3.37e-05483217920003
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH2 NOTCH4

3.37e-05483228061457
Pubmed

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.

DLL4 NOTCH2

3.37e-05483232820046
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH2 NOTCH4

3.37e-05483211466531
Pubmed

Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

WNT6 EPHA4

3.37e-05483225959774
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH2 NOTCH4

3.37e-05483224151014
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH2 NOTCH4

3.37e-05483210194420
Pubmed

Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload.

EGFR WNT5A

3.37e-05483234564708
Pubmed

LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

DLL4 NOTCH2

3.37e-05483238462037
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH2 NOTCH4

3.37e-05483211459941
Pubmed

Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.

EGFR PLAUR

3.37e-05483221391216
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH2 NOTCH4

3.37e-05483218184405
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH2 NOTCH4

3.37e-05483215917835
InteractionPOTED interactions

POTEB3 POTED POTEC

2.59e-074823int:POTED
InteractionNOTCH4 interactions

DLL4 TRRAP NOTCH2 NOTCH4

1.45e-0621824int:NOTCH4
InteractionPOTEC interactions

POTEB3 POTED POTEC

1.80e-0513823int:POTEC
Cytoband10p12.31

MALRD1 CUBN

7.46e-042284210p12.31
Cytoband19q13

KLK10 PLAUR

1.49e-033184219q13
CytobandEnsembl 112 genes in cytogenetic band chr5p13

ADAMTS12 DROSHA C6

2.16e-03139843chr5p13
CytobandEnsembl 112 genes in cytogenetic band chr10p12

SLC39A12 MALRD1 SPAG6

2.21e-03140843chr10p12
CytobandEnsembl 112 genes in cytogenetic band chr22q13

CELSR1 EFCAB6 ACR SREBF2

3.22e-03330844chr22q13
CytobandEnsembl 112 genes in cytogenetic band chr1q25

SEC16B HMCN1 RC3H1

3.63e-03167843chr1q25
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTED POTEC

8.25e-0413602685
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHA4 EPHA8

9.61e-04146021095
GeneFamilyAnkyrin repeat domain containing

POTED ANKRD6 POTEC NOTCH2 NOTCH4

1.24e-03242605403
GeneFamilyWnt family|Endogenous ligands

WNT5A WNT6

1.79e-0319602360
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM7 ADAM8

3.60e-032760247
CoexpressionNABA_MATRISOME

ADAMTS12 RSPO3 EYS TMPRSS15 VWF HMCN1 CLEC17A WNT5A WNT6 ADAM7 SEMA5A ADAM8 LTBP4 MUC6 VWDE SVEP1

1.42e-0710268416M5889
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP

DLL4 WNT5A PLAUR NOTCH2 NOTCH4 EPHA4 EPHA8

9.58e-07163847M12112
CoexpressionNABA_ECM_GLYCOPROTEINS

RSPO3 EYS VWF HMCN1 LTBP4 VWDE SVEP1

3.27e-06196847M3008
CoexpressionNABA_MATRISOME

ADAMTS12 RSPO3 TMPRSS15 VWF HMCN1 WNT5A WNT6 ADAM7 SEMA5A ADAM8 LTBP4 MUC6 VWDE SVEP1

3.65e-0610088414MM17056
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 NOTCH2 NOTCH4

1.73e-0516843MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 NOTCH2 NOTCH4

1.73e-0516843M2207
CoexpressionNABA_CORE_MATRISOME

RSPO3 EYS VWF HMCN1 LTBP4 VWDE SVEP1

2.95e-05275847M5884
CoexpressionHEVNER_CORTEX_VASCULAR_ENDOTHELIAL_CELLS

VWF DLL4 NOTCH4

2.96e-0519843MM420
CoexpressionNABA_ECM_GLYCOPROTEINS

RSPO3 VWF HMCN1 LTBP4 VWDE SVEP1

3.51e-05191846MM17059
CoexpressionGSE10094_LCMV_VS_LISTERIA_IND_EFF_CD4_TCELL_DN

PTOV1 PATL2 ISX ISL2 SIGLEC1 CFI

4.54e-05200846M3047
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK10 VWF PDLIM3 DLL4 CFI LTBP4 EPHA4

6.38e-081868471e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 ACR CFI LTBP4 EPHA4

7.38e-081908473b9abc25b17e7295356ded57ff2ca519fa9f2686
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

ADAMTS12 RSPO3 PDLIM3 EGFR CLEC17A DLL4 WNT5A

8.51e-08194847eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 CUBN LTBP4 NOTCH4

1.35e-06184846087666ba949b129c53d7ace40f9e543e3875a7de
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 ACR LTBP4 EPHA4

1.43e-06186846ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 ACR LTBP4 EPHA4

1.43e-06186846ed924852cd7132c8f6703522037dc22bd2c83193
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KLK10 VWF PDLIM3 DLL4 LTBP4 NOTCH4

1.52e-0618884650b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF HMCN1 DLL4 LTBP4 NOTCH4 EPHA4

1.67e-061918464b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK10 PDLIM3 DLL4 LTBP4 NOTCH4 EPHA4

1.67e-06191846b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellCOPD-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

ADAMTS12 PDLIM3 HMCN1 EGFR LTBP4 SVEP1

2.00e-06197846d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCellbackground-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

RSPO3 PDLIM3 HMCN1 SEMA5A LTBP4 SVEP1

2.06e-0619884679f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

RSPO3 PDLIM3 HMCN1 SEMA5A LTBP4 SVEP1

2.06e-06198846bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF PDLIM3 DLL4 LTBP4 NUP160

3.11e-06119845c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 EGFR WNT5A SEMA5A CHAT

7.89e-061448450322fef818a963be00535d5f141f028d43de5c6a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK10 EFCAB6 WNT5A PJVK C6

1.06e-05153845edf5d026e8e4c685b7c369d70894741bb2cd568e
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK10 EFCAB6 WNT5A PJVK C6

1.06e-051538453240d4d690335ba22317b1f3d33f9ea069e93838
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 EGFR WNT5A SEMA5A CHAT

1.13e-051558453b8def9e8f66511736ea37f259511f7c8b7743af
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SLCO1C1 HMCN1 WNT5A LTBP4

1.24e-05158845ba9998cbf786c515d30fe42de02c7a246db1b6f9
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SLCO1C1 HMCN1 WNT5A LTBP4

1.24e-05158845a2efcc184ef13d81373e3690253ba35f6be09c5f
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SLCO1C1 HMCN1 WNT5A LTBP4

1.24e-05158845e52eff2bd1e7e0ce9c278ed5109802865e0fe69c
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PATL2 IKZF3 OVCH2 ISL2 LRRC52

1.40e-0516284522f1abd20f43bc7e7fc46969da9962faf70ae5d2
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PATL2 IKZF3 OVCH2 ISL2 LRRC52

1.40e-05162845966df4558140c3d541999ab553f201ae76a1c401
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

ADAMTS12 HMCN1 DLL4 LTBP4 SVEP1

1.48e-051648452ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 KLK10 VWF PDLIM3 ISX

1.62e-05167845a4a795751644b22af616335379e64ae95175180c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 EGFR WNT5A SEMA5A CHAT

1.76e-0517084514aa86a4f526ed6986afcb28c49225522055550c
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWF HMCN1 DLL4 ACR NOTCH4

1.81e-051718451597459c971d6befa991d59dc66b41b6a522f797
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 EGFR WNT5A SEMA5A CHAT

2.08e-0517684505ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCellfacs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 TMPRSS15 CELSR1 ANKRD6 LTBP4

2.08e-05176845057d2759fdc67176c25802b57a78064d8cc93205
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 TMPRSS15 CELSR1 ANKRD6 LTBP4

2.08e-05176845b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

RSPO3 VWF HMCN1 DLL4 LTBP4

2.08e-0517684552af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PDLIM3 EGFR WNT6 CFI SVEP1

2.14e-051778453d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CELSR1 KLK10 FCGBP WNT5A BDKRB2

2.14e-05177845779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CELSR1 KLK10 FCGBP WNT5A BDKRB2

2.14e-051778450f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF DNAJA4 PJVK ADAM8 NOTCH2

2.20e-0517884509d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_late|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ZNF516-DT KLK10 OVCH2 WNT6 VWDE

2.20e-0517884503f22485074b3cbf9a6ad4d543c5bbfa826dc741
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK10 VWF PDLIM3 DLL4 LTBP4

2.26e-05179845a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 LTBP4 NUP160

2.32e-05180845baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO4 ADAMTS12 PDLIM3 WNT5A SVEP1

2.32e-05180845280ff5c8f292be1b88120db5ff1788b750644856
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO4 ADAMTS12 PDLIM3 WNT5A SVEP1

2.32e-05180845fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 LTBP4 NUP160

2.32e-051808452d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 LTBP4 NUP160

2.32e-051808450f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRIM45 PDLIM3 HMCN1 WNT5A LTBP4

2.38e-05181845b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

CELSR1 KLK10 OVCH2 EGFR SEMA5A

2.38e-051818456d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS12 VWF WNT6 SEMA5A NOTCH4

2.44e-05182845e67f3234165199085c793915ebb1f9bbd845e933
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

2.44e-05182845ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

2.44e-0518284547ff6b4002a4167412c79210651316d1342503f9
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

2.51e-051838456f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF PDLIM3 DLL4 ACR LTBP4

2.51e-0518384512e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF PDLIM3 CFI BDKRB2 NOTCH4

2.51e-05183845858682df5592c6856487487a7baabd6e60e63a38
ToppCellCOPD-Epithelial-Basal|COPD / Disease state, Lineage and Cell class

CELSR1 KLK10 OVCH2 EGFR SEMA5A

2.51e-051838450f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCell3'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF PDLIM3 CFI BDKRB2 NOTCH4

2.51e-05183845f8212bf8a8b8312434ae030261c558c147f61747
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 VWF PDLIM3 HMCN1 CFI

2.51e-05183845b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

2.57e-05184845f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

2.57e-051848458bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCelldroplet-Lung-nan-21m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF PDLIM3 DLL4 LTBP4 NOTCH4

2.71e-051868455d0cd07b6b51e8ce9e1da949f757dc4575ec5752
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 ACR NOTCH4

2.71e-05186845b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 LTBP4 NOTCH4

2.71e-051868459c7924875f70420720149287c500b4dfa8d24673
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 PDLIM3 HMCN1 LTBP4 SVEP1

2.71e-051868455473283fb95cee556b1f6934cf72169b676b5bcc
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 ACR NOTCH4

2.71e-051868458a8ed1502542d4895cba3fd5d534256206578716
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

VWF HMCN1 DLL4 NOTCH4 EPHA4

2.71e-051868452d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 LTBP4 NOTCH4

2.78e-0518784512129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 LTBP4 NOTCH4

2.78e-0518784583930ef55191eff9006113feaeabb3c2fa21fd05
ToppCelldroplet-Lung-nan-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 CELSR1 ACR ANKRD6 LTBP4

2.85e-05188845a6ed43fdd42d681c9fbb2fb368947ab7e41d8d7c
ToppCelldroplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO3 CELSR1 ACR ANKRD6 LTBP4

2.85e-0518884554550313db78b3b5b572fa1e67092c8f6f33aab5
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF PDLIM3 DLL4 LTBP4 NOTCH4

2.85e-05188845405efea75233ecf70f7d19b630230798d817b7f2
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma-3|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

KLHL1 POTED VWDE POTEC

2.91e-0593844be5bd6d0a1d23c9aca6436c247ed173d009e7623
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF HMCN1 DLL4 LTBP4 NOTCH4

2.93e-05189845b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PDLIM3 DLL4 ACR NOTCH4

2.93e-051898452e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWF DLL4 LTBP4 NOTCH4 EPHA4

3.00e-05190845bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF DLL4 CUBN BDKRB2 NOTCH4

3.00e-0519084506bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF HMCN1 DLL4 LTBP4 NOTCH4

3.00e-05190845aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RSPO3 PDLIM3 CFI LTBP4 SVEP1

3.08e-05191845f5ce33af56178333730be308253943c54a0724cf
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

3.08e-051918456e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLK10 VWF PDLIM3 DLL4 LTBP4

3.08e-05191845482db995930346be69072ace2fd78fd453e97fb5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO4 ADAMTS12 PDLIM3 WNT5A SVEP1

3.16e-051928454022f208eb5db760abd0aac782a25e8ab63efc64
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLHL1 VWF HMCN1 C6 BDKRB2

3.16e-0519284552acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellNon-neuronal-Non-dividing-Radial_Glia-oRG-26|World / Primary Cells by Cluster

PDLIM3 SLCO1C1 EGFR SEMA5A NOTCH2

3.16e-05192845b8cf9c3c6b954e93f7504d214e39662bfa8f96f5
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RSPO3 KLHL1 VWF HMCN1 C6

3.16e-0519284581baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 PDLIM3 SEMA5A LTBP4 SVEP1

3.16e-051928453d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO4 ADAMTS12 PDLIM3 WNT5A SVEP1

3.16e-051928459333aba0d04203ccccad78d82bf6359922f810a7
ToppCellLPS-IL1RA-Endothelial-Endothelial-Vein|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RSPO3 VWF HMCN1 C6 BDKRB2

3.16e-05192845717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCellNon-neuronal-Non-dividing-Radial_Glia-oRG-34|World / Primary Cells by Cluster

PDLIM3 SLCO1C1 EGFR SEMA5A NOTCH2

3.23e-05193845d55f792eb3db10452347681131e07e041348fd89
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS12 PDLIM3 HMCN1 LTBP4 SVEP1

3.23e-05193845b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RSPO3 KLHL1 VWF HMCN1 C6

3.23e-051938457261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

PDLIM3 SLCO1C1 SEMA5A CFI NOTCH2

3.32e-051948457c6c0376603e5fcb64814fd6204d153629c2fbf5
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

VWF HMCN1 CFI NOTCH4 EPHA4

3.32e-051948457b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RSPO3 SEC16B SEMA5A LTBP4 SVEP1

3.32e-05194845439d3f17c1f4736122b330e98add9292c7036a8e
ToppCellControl-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

ADAMTS12 PDLIM3 HMCN1 LTBP4 SVEP1

3.32e-051948453c2266772c5b56e8e02a461e5193e29588028ee9
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 PDLIM3 SEMA5A LTBP4 SVEP1

3.32e-051948456e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellNon-neuronal-Non-dividing-Radial_Glia-oRG|World / Primary Cells by Cluster

PDLIM3 SLCO1C1 EGFR SEMA5A NOTCH2

3.32e-051948453a4bf6a7fac0e5bdbb4bb17041806d06a75974d9
ToppCellControl-Stromal-Myofibroblast|Control / Disease state, Lineage and Cell class

ADAMTS12 PDLIM3 HMCN1 LTBP4 SVEP1

3.40e-05195845ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 PDLIM3 WNT5A CUBN LTBP4

3.40e-05195845d32716a12014522492becbde1088dc1106308490
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 PDLIM3 WNT5A CUBN LTBP4

3.40e-05195845b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCellPCW_05-06-Mesenchymal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 SEMA5A LTBP4 SVEP1 NOTCH2

3.48e-05196845dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCellCOPD-Stromal-Myofibroblast|COPD / Disease state, Lineage and Cell class

PDLIM3 HMCN1 EGFR LTBP4 SVEP1

3.48e-05196845af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 VWF PDLIM3 SLCO1C1 HMCN1

3.48e-051968457d5eaed189aa6116f3799be010139fb675ec65e0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RSPO3 VWF DLL4 LTBP4 NOTCH4

3.48e-05196845a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 PDLIM3 HMCN1 LTBP4 SVEP1

3.48e-051968459737a5f006d37b549f281e1863aca558e1e4dc99
ToppCellControl-Stromal-Fibroblast|Control / Disease state, Lineage and Cell class

RSPO3 PDLIM3 EGFR LTBP4 SVEP1

3.48e-051968457ca94477498a84cafcdd9933ee92a6cbde76c70e
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS12 PDLIM3 HMCN1 LTBP4 SVEP1

3.48e-05196845cecf82cd5e0a3835d655f5e7478578674a63ce25
DrugAC1NRA23

ACR POTED CUBN BDKRB2 POTEC

6.64e-0673825CID005287657
DrugMethacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A

KRT2 SLCO1C1 ADAM7 SEMA5A CHAT CFI SVEP1

7.17e-061978274143_UP
DiseaseHereditary Diffuse Gastric Cancer

PTOV1 KLK10 FCGBP EGFR SREBF2 MUC6 RXRB NOTCH2

1.22e-06293798C1708349
DiseaseStomach Neoplasms

PTOV1 KLK10 FCGBP EGFR SREBF2 MUC6 RXRB NOTCH2

1.35e-06297798C0038356
DiseaseMalignant neoplasm of stomach

PTOV1 KLK10 FCGBP EGFR SREBF2 MUC6 RXRB NOTCH2

1.45e-06300798C0024623
DiseaseMalignant neoplasm of breast

RSPO3 SLC39A12 KLK10 VWF EGFR DLL4 SREBF2 CUBN SPAG6 RXRB NOTCH2 NOTCH4

2.75e-0510747912C0006142
Diseasehemangioblastoma (is_marker_for)

DLL4 NOTCH4

4.23e-054792DOID:5241 (is_marker_for)
DiseaseMammary Carcinoma, Human

RSPO3 KLK10 EGFR DLL4 SREBF2 RXRB NOTCH2 NOTCH4

8.21e-05525798C4704874
DiseaseMammary Neoplasms, Human

RSPO3 KLK10 EGFR DLL4 SREBF2 RXRB NOTCH2 NOTCH4

8.21e-05525798C1257931
DiseaseMammary Neoplasms

RSPO3 KLK10 EGFR DLL4 SREBF2 RXRB NOTCH2 NOTCH4

8.43e-05527798C1458155
DiseaseBreast Carcinoma

RSPO3 KLK10 EGFR DLL4 SREBF2 RXRB NOTCH2 NOTCH4

9.72e-05538798C0678222
Diseasecervical cancer

EGFR WNT5A NOTCH2

1.04e-0434793C4048328
DiseaseUterine Cervical Neoplasm

EGFR WNT5A NOTCH2

1.14e-0435793C0007873
Diseasevitamin supplement exposure measurement, Cleft palate, cleft lip, parental genotype effect measurement

RSPO3 KLHL1

1.96e-048792EFO_0003959, EFO_0005939, EFO_0009116, HP_0000175
Diseasehemangiopericytoma (is_marker_for)

DLL4 NOTCH4

2.52e-049792DOID:264 (is_marker_for)
Diseasediabetic retinopathy (is_marker_for)

VWF EGFR DLL4

4.15e-0454793DOID:8947 (is_marker_for)
Diseaseage at diagnosis, type 1 diabetes mellitus

EYS IKZF3 NOTCH4

6.23e-0462793EFO_0004918, MONDO_0005147
Diseaseurokinase plasminogen activator surface receptor measurement

ASGR1 PLAUR

6.31e-0414792EFO_0010932
DiseaseProteinuria

VWF CUBN

7.27e-0415792HP_0000093
DiseaseGastro-enteropancreatic neuroendocrine tumor

IKZF3 NOTCH2

7.27e-0415792C2930967
Diseasemethylcobalamin deficiency type cblE, brain serotonin transporter measurement

VWF EPHA4

8.29e-0416792EFO_0004569, MONDO_0009354
Diseaseglomerulonephritis (implicated_via_orthology)

C6 CFI

9.38e-0417792DOID:2921 (implicated_via_orthology)
DiseaseDisease Exacerbation

PTOV1 EGFR SREBF2 RXRB

1.02e-03165794C0235874
DiseaseAge-related macular degeneration

HMCN1 CFI

1.05e-0318792cv:C0242383
DiseaseCarcinoma of bladder

NOTCH2 EPHA4

1.05e-0318792C0699885
Diseasetype 1 diabetes mellitus (biomarker_via_orthology)

VWF EGFR

1.18e-0319792DOID:9744 (biomarker_via_orthology)
DiseaseGlioblastoma

EGFR LTBP4 NOTCH2

1.26e-0379793C0017636
Diseaseblood aluminium measurement

TRIM45 EPHA4

1.30e-0320792EFO_0007575
DiseaseInfiltrating duct carcinoma of female breast

CDK15 EPHA8

1.44e-0321792C3165106
DiseaseGiant Cell Glioblastoma

EGFR LTBP4 NOTCH2

1.51e-0384793C0334588
Diseaseremission, hepatitis C virus infection

MALRD1 NOTCH4

1.73e-0323792EFO_0003047, EFO_0009785
Diseaseunipolar depression, neuroticism measurement

ANO4 EYS

1.88e-0324792EFO_0003761, EFO_0007660
Diseasechronic obstructive pulmonary disease (biomarker_via_orthology)

EGFR PLAUR

2.56e-0328792DOID:3083 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
MAALQGNGSERTCCP

ASGR1

141

P07306
VGMGNGTPCSLKQNR

ERLEC1

191

Q96DZ1
CQKGGCRSEPIQMEN

BDKRB2

351

P30411
CKGDSGGPLVCMDAN

CFI

521

P05156
CQGDSGGPLMCKDSK

ACR

236

P10323
SGTKCGEGMVCNNGE

ADAM7

606

Q9H2U9
AGIKCQVDRMSFPCG

CSRNP2

231

Q9H175
CANGGQCLNRGPSRM

DLL4

411

Q9NR61
GSVEKCPLCKGRGMQ

DNAJA4

146

Q8WW22
CENMGACVRSPGSPQ

CELSR1

1916

Q9NYQ6
DMATGQCACKPGVIG

CELSR1

2016

Q9NYQ6
ADMCGVLQCKGGQQP

ADAM8

546

P78325
GPCAGQGEAGQKCMV

ANO4

806

Q32M45
MNDQGKCLRGEGTCI

ACRV1

196

P26436
GGNSRNVCINGICKM

ADAMTS12

661

P58397
DGKVMQAPINGCRCE

ANKRD6

401

Q9Y2G4
GPALCRGMERNSLGC

ISX

6

Q2M1V0
RGMERNSLGCCEAPK

ISX

11

Q2M1V0
DMKQRGGCPRGASCT

RC3H1

421

Q5TC82
VGGPGSGKTQVCLCM

RAD51D

106

O75771
LCDVPCSGDGTMRKN

NSUN2

266

Q08J23
DPLCGLCGNFNGNMK

MUC6

996

Q6W4X9
LANPCQNGGSCMDGV

NOTCH2

916

Q04721
LMKCGNGGTCIESGT

EYS

2616

Q5T1H1
GMQLLCGGLRHPNCM

NLRP11

876

P59045
MSCQISCKSRGRGGG

KRT2

1

P35908
SCQGDSGGPLMCQEN

TMPRSS15

966

P98073
RDCNSLPGVMGTCKE

EPHA4

106

P54764
FGMGLVSGSKCPNNC

LRRC52

16

Q8N7C0
CGGPDSQIQRCNTDM

HMCN1

4796

Q96RW7
DLCPNGMTKAENGTC

HMCN1

5256

Q96RW7
DCDSLKGLCRIMGNG

PTOV1

171

Q86YD1
RFPCCRGSGKSNMGT

POTEB3

31

A0JP26
RNGGTCVVEKNGPMC

MALRD1

2031

Q5VYJ5
MNCLEGPGKTCGPLA

PATL2

1

C9JE40
CTCVGAGDPRLAKMQ

UPF1

626

Q92900
PLSCQNGGTCVNTMG

CUBN

181

O60494
ECLPQAMNITCTGRG

EGFR

561

P00533
AMNITCTGRGPDNCI

EGFR

566

P00533
CVKTCPAGVMGENNT

EGFR

591

P00533
MGQELCAKTVQPGCS

CDK15

1

Q96Q40
GQKQSGSECICMSPE

C6

776

P13671
KRGGGNEMNCCRTLR

EFCAB6

146

Q5THR3
GAVCGLCGNMDRNPN

FCGBP

4211

Q9Y6R7
RDCNSMPGVLGTCKE

EPHA8

106

P29322
GCILGDEMGLGKTCQ

CHD1L

66

Q86WJ1
CGVMRGCGLAPSLSK

HOXC10

41

Q9NYD6
SGMCQRNPQVCGPGR

LTBP4

546

Q8N2S1
PASMSGSCGACINGK

KLHDC1

66

Q8N7A1
SRPTSGKMNCDVCGL

IKZF3

111

Q9UKT9
KTGCPRRRNGMQGDC

SLC39A12

71

Q504Y0
RFPCCKGSGKSNMGT

POTEC

31

B2RU33
KPGTAMCVGCGSQIH

ISL2

21

Q96A47
RFPCCRGSGKSNMGT

POTED

31

Q86YR6
DPGQMNDGPLCKCSA

DROSHA

526

Q9NRR4
SGGQKTARCACGGTM

TRIM45

516

Q9H8W5
NSCGAPMQGDDVLRC

SMYD4

621

Q8IYR2
CIGSCKGNTRLPGIM

SPAG6

301

O75602
CQGDSGGSLMCRNKK

OVCH2

236

Q7RTZ1
RAKMCGLGCAPSAGS

SPPL2C

531

Q8IUH8
SNISCGNEKEPSMCG

SETMAR

311

Q53H47
GGAQRMPLCDKCGSG

PDLIM3

286

Q53GG5
GSVLRGRMCVNCPLG

SVEP1

991

Q4LDE5
PCLCSVGRRGDGGKM

NUP160

21

Q12769
RGCSNGGTCQLMPEK

NOTCH4

241

Q99466
GKVLCACQVAQGAMP

AARS2

921

Q5JTZ9
MAVPGCNKDSVRAGC

SREK1IP1

1

Q8N9Q2
AGQCGPVGVRKEMHC

RXRB

16

P28702
QCEGPGMEIANCSRN

SEMA5A

581

Q13591
TDCAKGQLSGQPLCM

CHAT

256

P28329
NQRSGGPGCCQKRWM

CLEC17A

156

Q6ZS10
SCRVCGGKHEPNMQL

UHRF2

346

Q96PU4
DPTCMNGGKCVGPST

VWDE

1491

Q8N2E2
DCRGPMNQCLVATGT

PLAUR

236

Q03405
GACSPGARQGCMKSI

VWF

1991

P04275
NHNIPKGPCILCGMG

PJVK

301

Q0ZLH3
KGPCILCGMGNFKRE

PJVK

306

Q0ZLH3
MEACEDGGCQGPLKS

TMEM247

56

A6NEH6
GIVGRCQKDNGCPQM

SLCO1C1

536

Q9NYB5
SCNDCQQMIVKLGGG

SREBF2

1121

Q12772
MGELLQCGCQAPRGR

WNT6

126

Q9Y6F9
RRMHPNVSQGCQGGC

RSPO3

31

Q9BXY4
QGRLCNKTSEGMDGC

WNT5A

321

P41221
GGCSTCGGCSPRMKV

SIGLEC1

651

Q9BZZ2
MSGRIPQAATCCGEK

SEC16B

506

Q96JE7
EKPMVCGECGRGFSQ

ZNF133

491

P52736
RMCPKAGDQTGGAFC

ZNF516-DT

101

Q6ZTR6
KPLQRGIAACMTCGN

TRRAP

2191

Q9Y4A5
APMCKRRGGVGVATC

KLHL1

631

Q9NR64
NNMICAGLDRGQDPC

KLK10

211

O43240