Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	KDM5B EGFR NFATC4 DCHS1 SCRIB ARHGAP35 CDC42 PLXNB2 SAPCD2	2.97e-05	619	54	9	GO:0002009
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	DCHS1 SCRIB CDC42 SAPCD2	3.99e-05	73	54	4	GO:0001738
GeneOntologyBiologicalProcess	positive regulation of synapse structural plasticity	FRMPD4 CDC42	4.02e-05	4	54	2	GO:0051835
GeneOntologyBiologicalProcess	establishment of monopolar cell polarity	GBF1 SCRIB CDC42	5.31e-05	28	54	3	GO:0061162
GeneOntologyBiologicalProcess	establishment or maintenance of monopolar cell polarity	GBF1 SCRIB CDC42	5.91e-05	29	54	3	GO:0061339
GeneOntologyBiologicalProcess	camera-type eye development	TBC1D32 KDM5B EGFR SCRIB ARHGAP35 ATP2B2 SDK1	1.17e-04	426	54	7	GO:0043010
GeneOntologyBiologicalProcess	tissue morphogenesis	KDM5B EGFR NFATC4 DCHS1 SCRIB ARHGAP35 CDC42 PLXNB2 SAPCD2	1.30e-04	750	54	9	GO:0048729
GeneOntologyBiologicalProcess	neural tube development	TBC1D32 DCHS1 SCRIB ARHGAP35 PLXNB2	1.84e-04	202	54	5	GO:0021915
GeneOntologyBiologicalProcess	eye development	TBC1D32 KDM5B EGFR SCRIB ARHGAP35 ATP2B2 SDK1	2.43e-04	480	54	7	GO:0001654
GeneOntologyBiologicalProcess	visual system development	TBC1D32 KDM5B EGFR SCRIB ARHGAP35 ATP2B2 SDK1	2.53e-04	483	54	7	GO:0150063
GeneOntologyBiologicalProcess	sensory system development	TBC1D32 KDM5B EGFR SCRIB ARHGAP35 ATP2B2 SDK1	2.79e-04	491	54	7	GO:0048880
GeneOntologyBiologicalProcess	neuron development	LIMK1 EGFR NFATC4 ZNF212 LRTM1 SCRIB ARHGAP35 ATAT1 CDC42 PLXNB2 ATP2B2 SDK1	3.25e-04	1463	54	12	GO:0048666
GeneOntologyBiologicalProcess	DNA-templated transcription initiation	SETD1A TFB1M MDC1 MED14 OGG1	3.41e-04	231	54	5	GO:0006352
GeneOntologyBiologicalProcess	neuron projection development	LIMK1 EGFR NFATC4 ZNF212 LRTM1 SCRIB ARHGAP35 CDC42 PLXNB2 ATP2B2 SDK1	4.21e-04	1285	54	11	GO:0031175
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	FRMPD4 CDC42	4.37e-04	12	54	2	GO:0051823
GeneOntologyCellularComponent	nuclear speck	SETD1A CRNKL1 LIMK1 NFATC4 SAP18 CDK13 OGG1	2.52e-04	431	61	7	GO:0016607
GeneOntologyCellularComponent	apical part of cell	EGFR ADGRG2 DYNC2LI1 DCHS1 SCRIB CDC42 SAPCD2 ATP2B2	3.10e-04	592	61	8	GO:0045177
HumanPheno	Colorectal polyposis	KLLN POLD1 RNF43 SEC23B	2.15e-06	24	21	4	HP:0200063
HumanPheno	Large intestinal polyposis	KLLN POLD1 RNF43 SEC23B	7.13e-06	32	21	4	HP:0030255
HumanPheno	Neoplasm of the rectum	KLLN POLD1 RNF43 SEC23B	3.11e-05	46	21	4	HP:0100743
HumanPheno	Intestinal polyposis	KLLN POLD1 RNF43 SEC23B	1.02e-04	62	21	4	HP:0200008
HumanPheno	Breast carcinoma	KLLN POLD1 RNF43 SEC23B	1.38e-04	67	21	4	HP:0003002
HumanPheno	Intestinal polyp	KLLN POLD1 RNF43 SEC23B	1.38e-04	67	21	4	HP:0005266
HumanPheno	Endometrial carcinoma	KLLN POLD1 SEC23B	1.48e-04	26	21	3	HP:0012114
HumanPheno	Hair follicle neoplasm	KLLN SEC23B	1.61e-04	5	21	2	HP:0012843
HumanPheno	Trichilemmoma	KLLN SEC23B	1.61e-04	5	21	2	HP:0012844
HumanPheno	Abnormal endometrium morphology	KLLN POLD1 SEC23B	1.85e-04	28	21	3	HP:0030126
HumanPheno	Tumours of the breast	KLLN POLD1 RNF43 SEC23B	1.93e-04	73	21	4	HP:0010623
HumanPheno	Urinary tract neoplasm	KLLN POLD1 OGG1 RNF43 SEC23B	2.38e-04	144	21	5	HP:0010786
HumanPheno	Abnormal rectum morphology	LIMK1 KLLN POLD1 RNF43 SEC23B	2.46e-04	145	21	5	HP:0002034
HumanPheno	Hypoplasia of the corpus callosum	KDM5B FRMPD4 SACS CDK13 DCHS1 CDC42 UNC80 RAI1	3.83e-04	478	21	8	HP:0002079
Domain	DUF1220	NBPF3 NBPF1	3.02e-04	9	55	2	SM01148
Domain	NBPF_dom	NBPF3 NBPF1	4.60e-04	11	55	2	IPR010630
Domain	NBPF	NBPF3 NBPF1	4.60e-04	11	55	2	PS51316
Domain	DUF1220	NBPF3 NBPF1	4.60e-04	11	55	2	PF06758
Domain	PDZ	LIMK1 FRMPD4 FRMPD1 SCRIB	7.88e-04	141	55	4	PF00595
Domain	PDZ	LIMK1 FRMPD4 FRMPD1 SCRIB	9.43e-04	148	55	4	SM00228
Domain	-	LIMK1 FRMPD4 FRMPD1 SCRIB	9.92e-04	150	55	4	2.30.42.10
Domain	PDZ	LIMK1 FRMPD4 FRMPD1 SCRIB	1.02e-03	151	55	4	PS50106
Domain	PDZ	LIMK1 FRMPD4 FRMPD1 SCRIB	1.04e-03	152	55	4	IPR001478
Domain	Rho_GTPase_activation_prot	ARHGAP35 CHN2 PLXNB2	2.22e-03	88	55	3	IPR008936
Domain	IPT	NFATC4 PLXNB2	2.85e-03	27	55	2	SM00429
Domain	CARD	CASP9 CARD10	3.06e-03	28	55	2	PF00619
Domain	TIG	NFATC4 PLXNB2	3.75e-03	31	55	2	PF01833
Domain	CARD	CASP9 CARD10	3.75e-03	31	55	2	IPR001315
Domain	IPT	NFATC4 PLXNB2	3.99e-03	32	55	2	IPR002909
Domain	CARD	CASP9 CARD10	4.24e-03	33	55	2	PS50209
Domain	FERM_M	FRMPD4 FRMPD1	8.11e-03	46	55	2	PF00373
Domain	-	FRMPD4 FRMPD1	9.16e-03	49	55	2	1.20.80.10
Domain	FERM_central	FRMPD4 FRMPD1	9.16e-03	49	55	2	IPR019748
Domain	FERM_domain	FRMPD4 FRMPD1	9.16e-03	49	55	2	IPR000299
Domain	FERM_1	FRMPD4 FRMPD1	9.53e-03	50	55	2	PS00660
Domain	FERM_2	FRMPD4 FRMPD1	9.53e-03	50	55	2	PS00661
Domain	FERM_3	FRMPD4 FRMPD1	9.53e-03	50	55	2	PS50057
Domain	Band_41_domain	FRMPD4 FRMPD1	9.53e-03	50	55	2	IPR019749
Domain	B41	FRMPD4 FRMPD1	9.53e-03	50	55	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	FRMPD4 FRMPD1	9.53e-03	50	55	2	IPR014352
Domain	TPR-contain_dom	CRNKL1 PRMT9 CABIN1	9.82e-03	150	55	3	IPR013026
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF3 NBPF19 NBPF12 NBPF10 NBPF20 NBPF1	1.20e-12	21	61	6	16079250
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A TNRC18 GBF1 CDK13 MED14 CARD10 ARHGAP35 CABIN1 PLXNB2 RNF43 RAI1 NBPF1	4.13e-07	1105	61	12	35748872
Pubmed	Cdc42 induces EGF receptor protein accumulation and promotes EGF receptor nuclear transport and cellular transformation.	EGFR CDC42	3.03e-06	2	61	2	25497016
Pubmed	Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria.	CASP9 OGG1	3.03e-06	2	61	2	15811855
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	LIMK1 EGFR SAP18 MDC1 NBPF10 CDC42 SDK1	3.13e-06	358	61	7	32460013
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GBF1 EGFR CDK13 CHTF18 MDC1 MED14 SCRIB ARHGAP35 PRRC2A	7.88e-06	774	61	9	15302935
Pubmed	Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1.	KDM5B EGFR	9.07e-06	3	61	2	29934325
Pubmed	β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.	EGFR ARHGAP35	9.07e-06	3	61	2	21937717
Pubmed	Association of hOGG1-Cys variants with occurrence of p53 and EGFR deletion mutations in non-small cell lung cancer.	EGFR OGG1	9.07e-06	3	61	2	33372419
Pubmed	Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P₃ receptor and Cdc42.	EGFR CDC42	9.07e-06	3	61	2	23142484
Pubmed	Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.	CDC42 PLXNB2	9.07e-06	3	61	2	21966369
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NBPF19 SETD1A TNRC18 GBF1 NFATC4 MDC1 NBPF20	1.03e-05	430	61	7	35044719
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF12 NBPF10 XPNPEP1 SDK1 NBPF1	1.25e-05	170	61	5	23314748
Pubmed	Grb2 mediates semaphorin-4D-dependent RhoA inactivation.	ARHGAP35 PLXNB2	1.81e-05	4	61	2	22505611
Pubmed	TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κB activation and tumor progression.	EGFR CARD10	1.81e-05	4	61	2	27991920
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNRC18 GBF1 SACS CDK13 UBR3 ARHGAP35 UNC80	2.48e-05	493	61	7	15368895
Pubmed	Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation.	EGFR CDC42	3.02e-05	5	61	2	14505571
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF12 FRMPD4 MDC1 NBPF10 MED14 ARHGAP35 NBPF1	3.20e-05	513	61	7	25798074
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETD1A FRMPD4 CABIN1 PLXNB2	3.45e-05	104	61	4	9205841
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TNRC18 CDK13 UNC80 RAI1	3.86e-05	107	61	4	11347906
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	CRNKL1 GBF1 CDK13 MDC1 CCDC88B PRRC2A	4.12e-05	361	61	6	26167880
Pubmed	Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).	FRMPD4 FRMPD1	4.52e-05	6	61	2	22074847
Pubmed	CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling.	SCRIB CDC42	4.52e-05	6	61	2	35021092
Pubmed	CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.	LIMK1 CDC42	4.52e-05	6	61	2	24792215
Pubmed	The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome.	EGFR CDC42	4.52e-05	6	61	2	24413169
Pubmed	Proteome-wide analysis of phospho-regulated PDZ domain interactions.	FRMPD4 SCRIB ATP2B2	5.61e-05	42	61	3	30126976
Pubmed	HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.	EGFR CDC42	6.32e-05	7	61	2	20086093
Pubmed	GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.	GBF1 EGFR	6.32e-05	7	61	2	18084281
Pubmed	Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.	LIMK1 CDC42	6.32e-05	7	61	2	25981171
Pubmed	Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.	EGFR CDC42	6.32e-05	7	61	2	23644655
Pubmed	A novel hook-related protein family and the characterization of hook-related protein 1.	EGFR CCDC88B	6.32e-05	7	61	2	15882442
Pubmed	Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.	EGFR CDC42	8.42e-05	8	61	2	16407834
Pubmed	Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox.	EGFR RNF43	8.42e-05	8	61	2	37011906
Pubmed	An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.	SCRIB PLXNB2	8.42e-05	8	61	2	21559415
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	CRNKL1 SAP18 CDK13 NBPF20 RAI1	9.33e-05	259	61	5	30404004
Pubmed	Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.	CDC42 PLXNB2	1.08e-04	9	61	2	25892012
Pubmed	Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.	ARHGAP35 CDC42	1.08e-04	9	61	2	9535855
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TNRC18 SAP18 MDC1 MED14 RAI1	1.09e-04	268	61	5	33640491
Pubmed	The DNA sequence of human chromosome 7.	LIMK1 TNRC18 EGFR CDK13 ZNF212 CHN2	1.24e-04	441	61	6	12853948
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF12 NBPF1	1.35e-04	10	61	2	22973535
Pubmed	Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2.	SCRIB CDC42	1.35e-04	10	61	2	19363157
Pubmed	Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.	DCHS1 SCRIB	1.65e-04	11	61	2	26114487
Pubmed	Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.	CDC42 PLXNB2	1.97e-04	12	61	2	12123608
Pubmed	Genetic variation in the base excision repair pathway and bladder cancer risk.	POLD1 OGG1	1.97e-04	12	61	2	17203305
Pubmed	Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.	EGFR CDC42	1.97e-04	12	61	2	15728722
Pubmed	Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.	LIMK1 CDC42	1.97e-04	12	61	2	26969129
Pubmed	Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.	EGFR CDC42	1.97e-04	12	61	2	12446789
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	EGFR SAP18 ATAT1 CDC42 PLXNB2	2.06e-04	307	61	5	37499664
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	SETD1A SAP18 POLD1 SCRIB PLXNB2	2.25e-04	313	61	5	38270169
Pubmed	Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.	LIMK1 CDC42	2.33e-04	13	61	2	30333726
Pubmed	Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.	LIMK1 SCRIB	2.33e-04	13	61	2	17229766
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	SETD1A KDM5B	2.33e-04	13	61	2	24619213
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	LIMK1 EGFR ARHGAP35 OGG1 RAI1	2.91e-04	331	61	5	20634891
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TNRC18 SACS SCRIB OGG1 PRRC2A	2.95e-04	332	61	5	37433992
Pubmed	Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.	LIMK1 CDC42	3.13e-04	15	61	2	22810622
Pubmed	A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.	EGFR CASP9 OGG1	3.17e-04	75	61	3	20644561
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	LIMK1 EGFR CDK13 SEC23B	3.26e-04	186	61	4	33637726
Pubmed	Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.	LIMK1 CDC42	3.57e-04	16	61	2	20067919
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CRNKL1 SAP18 CDK13 POLD1 CHTF18 MDC1 MED14 CDC42	3.81e-04	1014	61	8	32416067
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD1A MDC1 MED14 SCRIB ARHGAP35 PRRC2A	4.01e-04	549	61	6	38280479
Pubmed	LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.	MDC1 PRRC2A	4.05e-04	17	61	2	37072811
Pubmed	Genome-wide association study of atypical psychosis.	CHN2 PRRC2A	4.05e-04	17	61	2	24132900
Pubmed	Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.	LIMK1 CDC42	4.55e-04	18	61	2	21177343
Pubmed	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.	LIMK1 EGFR DCHS1 ATAT1 PLTP	5.21e-04	376	61	5	24154525
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	EGFR POLD1 CASP9 CARD10 OGG1	5.53e-04	381	61	5	18676680
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	CDC42 PLTP	5.63e-04	20	61	2	9828140
Pubmed	CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.	EGFR SCRIB	5.63e-04	20	61	2	19726564
Pubmed	Temporal and spatial transcriptional programs in murine kidney development.	NFATC4 CDC42	6.22e-04	21	61	2	15998744
Pubmed	The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.	LIMK1 CDC42	6.22e-04	21	61	2	31577955
Pubmed	SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.	POLD1 CHTF18	6.22e-04	21	61	2	24958773
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	GBF1 SCRIB ARHGAP35 UNC80	6.67e-04	225	61	4	12168954
Pubmed	microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.	CASP9 CDC42	6.83e-04	22	61	2	19015276
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	CRNKL1 DCHS1 PRRC2A	7.57e-04	101	61	3	26949739
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CRNKL1 EGFR CDK13 POLD1 CHTF18 MDC1 ARHGAP35 PRRC2A SEC23B	7.67e-04	1415	61	9	28515276
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	SETD1A CDK13 CHTF18 SCRIB CDC42	7.69e-04	410	61	5	26949251
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	CRNKL1 SAP18 RAI1	8.01e-04	103	61	3	32744500
Pubmed	Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.	EGFR CDC42	8.15e-04	24	61	2	19265663
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	GBF1 CHTF18 PRRC2A	8.24e-04	104	61	3	31240132
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	GEMIN2 POLD1 SCRIB PRRC2A	8.74e-04	242	61	4	34011540
Pubmed	Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.	POLD1 OGG1	8.84e-04	25	61	2	20226869
Pubmed	Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.	NFATC4 CDC42	9.57e-04	26	61	2	17177285
Pubmed	Polymorphisms in the base excision repair pathway and graft-versus-host disease.	POLD1 OGG1	1.03e-03	27	61	2	20574454
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	FRMPD4 SCRIB	1.03e-03	27	61	2	24550280
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1A CHTF18 MDC1 MED14 SCRIB	1.05e-03	440	61	5	34244565
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TFB1M SAP18 SCRIB ARHGAP35 CHN2 CDC42 PRRC2A	1.09e-03	916	61	7	32203420
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CRNKL1 TFB1M GEMIN2 CDK13 POLD1 MDC1 MED14 CDC42 PRRC2A	1.14e-03	1497	61	9	31527615
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	SAP18 CHTF18 ZNF496 SEC23B	1.17e-03	262	61	4	36880596
Pubmed	Mapping the Genetic Landscape of Human Cells.	TFB1M GEMIN2 SAP18 POLD1 MED14	1.17e-03	451	61	5	30033366
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	SETD1A POLD1 MDC1 MED14 CABIN1	1.20e-03	453	61	5	29656893
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	SETD1A SAP18 SCRIB SAPCD2	1.31e-03	270	61	4	24366813
Pubmed	A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.	POLD1 CHTF18	1.36e-03	31	61	2	12171929
Pubmed	The protein interaction landscape of the human CMGC kinase group.	LIMK1 CDK13 MED14 SCRIB ATAT1 SEC23B	1.36e-03	695	61	6	23602568
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SETD1A CRNKL1 KDM5B SAP18 CDK13	1.40e-03	469	61	5	27634302
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	KDM5B DYNC2LI1	1.45e-03	32	61	2	14613977
Pubmed	Genetic variations in humans associated with differences in the course of hepatitis C.	EGFR CABIN1	1.45e-03	32	61	2	15063762
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CRNKL1 TNRC18 SAP18 POLD1 CHTF18 MED14 CDC42 PRRC2A	1.46e-03	1247	61	8	27684187
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	KDM5B RNF43	1.54e-03	33	61	2	19336002
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	EGFR CDK13 SCRIB	1.67e-03	133	61	3	15144186
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	EGFR SCRIB	1.73e-03	35	61	2	37381005
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	SETD1A EGFR CDK13 CDC42 PLXNB2 SEC23B	1.75e-03	730	61	6	34857952
Interaction	TOP3B interactions	SETD1A TNRC18 GBF1 SAP18 CDK13 MDC1 MED14 CARD10 ARHGAP35 CABIN1 PLXNB2 PRRC2A RNF43 SEC23B RAI1 NBPF1	3.22e-06	1470	59	16	int:TOP3B
GeneFamily	Neuroblastoma breakpoint family	NBPF3 NBPF19 NBPF12 NBPF10 NBPF20 NBPF1	1.06e-11	23	42	6	662
GeneFamily	PDZ domain containing	LIMK1 FRMPD4 FRMPD1 SCRIB	4.19e-04	152	42	4	1220
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	CASP9 CARD10	2.20e-03	30	42	2	959
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP35 CHN2	6.01e-03	50	42	2	721
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMPD4 FRMPD1	6.01e-03	50	42	2	1293
Drug	Pesticides	NBPF12 EGFR NBPF10 OGG1 NBPF20 NBPF1	2.50e-06	150	59	6	ctd:D010575
Disease	high grade glioma (is_marker_for)	KDM5B EGFR RNF43	6.68e-05	42	55	3	DOID:3070 (is_marker_for)
Disease	Hamartoma Syndrome, Multiple	KLLN SEC23B	1.22e-04	9	55	2	C0018553
Disease	psychosis	CHN2 PRRC2A	3.06e-04	14	55	2	EFO_0005407
Disease	Endometrial Carcinoma	EGFR POLD1 RNF43	3.34e-04	72	55	3	C0476089
Disease	breast cancer (is_marker_for)	EGFR CDK13 CASP9 OGG1	3.97e-04	185	55	4	DOID:1612 (is_marker_for)
Disease	cholangiocarcinoma (is_implicated_in)	OGG1 RNF43	7.69e-04	22	55	2	DOID:4947 (is_implicated_in)
Disease	Intrahepatic Cholangiocarcinoma	EGFR RNF43	9.17e-04	24	55	2	C0345905
Disease	stomach carcinoma (is_marker_for)	MDC1 RNF43	9.17e-04	24	55	2	DOID:5517 (is_marker_for)
Disease	Extrahepatic Cholangiocarcinoma	EGFR RNF43	9.17e-04	24	55	2	C3805278
Disease	Cholangiocarcinoma	EGFR RNF43	1.08e-03	26	55	2	C0206698
Disease	pancreatic cancer (is_implicated_in)	EGFR CASP9 OGG1	1.21e-03	112	55	3	DOID:1793 (is_implicated_in)
Disease	17-hydroxyprogesterone measurement	MDC1 PRRC2A	1.34e-03	29	55	2	EFO_0010220
Disease	Intellectual Disability	SETD1A FRMPD4 SACS CDC42 RAI1	1.46e-03	447	55	5	C3714756
Disease	colorectal cancer (is_implicated_in)	EGFR CASP9 RNF43	1.51e-03	121	55	3	DOID:9256 (is_implicated_in)
Disease	Parkinsonism (biomarker_via_orthology)	EGFR CASP9	1.84e-03	34	55	2	DOID:0080855 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VEELCRFPELPARKP	CHTF18	821	Q8WVB6
RPVVLLPECLAPRLI	CARD10	846	Q9BWT7
PCIPLSKPVELLRLD	PRMT9	746	Q6P2P2
LLEREPLCLRPEAPS	CCDC88B	231	A6NC98
PLERILPPRLLEKSD	TBC1D32	881	Q96NH3
VRIPCPSSPEELEKL	ADGRG2	221	Q8IZP9
PLEVPKRLPRADAEV	C8orf89	76	P0DMQ9
KLRCLLADLPLPPEL	CDK13	641	Q14004
EDPVRPEVPEAIRKC	ATP2B2	706	Q01814
RAPVLPKDLLLPESC	RAI1	1016	Q7Z5J4
TEIARLKDEARPCPP	DCHS1	3181	Q96JQ0
RELLECELKPKPRPA	LRTM1	266	Q9HBL6
PERGPLERETEKLLP	MDC1	826	Q14676
VEELMPRLLPVEPCD	GEMIN2	21	O14893
TIILRCLDRDEPPKP	DYNC2LI1	46	Q8TCX1
SPLKLELRVLAPPRC	PLTP	321	P55058
ELRVLAPPRCTIKPS	PLTP	326	P55058
LLDPPRKRLVECGSL	PLXNB2	101	O15031
CRRSEKPPLEKILPL	KDM5B	1221	Q9UGL1
ALEPPEPKKSRRCVL	CDC42	176	P60953
ERGERVPKLVPLLAC	KLLN	156	B2CW77
IPCPRSELRLDLVLP	OGG1	26	O15527
PCPRLSRELLEAVEP	NBPF1	1036	Q3BBV0
TCIRDKIIPPDPITK	MED14	171	O60244
CPRLSRELPEVVEPE	NBPF3	476	Q9H094
EAPRPKRIICPREVE	CHN2	36	P52757
ILEKGERLPQPPICT	EGFR	926	P00533
REAKERELELLPPPP	CRNKL1	196	Q9BZJ0
TCEPPRPSLGKRIDL	CABIN1	286	Q9Y6J0
LEPLSDRRLVKLAPC	FRMPD1	536	Q5SYB0
PKDPIDLLRRDPVAF	FRMPD4	291	Q14CM0
LRPEIRKPEVLRPET	CASP9	111	P55211
VPEQELLRSLRLCPP	ATAT1	286	Q5SQI0
PRFSCLLPDPRELIE	GBF1	681	Q92538
PVPQLRKRSRCEIAP	KLHDC7B	126	Q96G42
TEKRERPAPPRELLV	SDK1	1471	Q7Z5N4
KELSLIPFLCPERAP	SACS	3646	Q9NZJ4
EPEPFLRLALTLRPC	POLD1	346	P28340
LDEIRKEFCGPIPPR	RTL5	221	Q5HYW3
FRFLPVICKEEPLPD	NFATC4	681	Q14934
DPPCPRLSRELLEVV	NBPF10	1251	Q6P3W6
PPCPRLSRELLEEKG	NBPF10	1346	Q6P3W6
PPCPRLSRELLEVVE	NBPF10	1496	Q6P3W6
PCPRLSRELLEVVEP	NBPF10	1741	Q6P3W6
DPPCPRLSRELLEVV	NBPF10	2471	Q6P3W6
PPCPRLSRELLEVVE	NBPF10	2716	Q6P3W6
PCPRLSRELLEVVEP	NBPF10	2961	Q6P3W6
PCPRLSRELLEVVEP	NBPF12	1036	Q5TAG4
DPPCPRLSRELVEVV	NBPF19	736	A0A087WUL8
PPCPRLSRELVEVVE	NBPF19	981	A0A087WUL8
PCPRLSRELVEVVEP	NBPF19	1226	A0A087WUL8
PPCPRLSRELLEVVE	NBPF19	2201	A0A087WUL8
PCPRLSRELLEVVEP	NBPF19	2446	A0A087WUL8
PPCPRLSRELLEVVE	NBPF19	3421	A0A087WUL8
PCPRLSRELLEVVEP	NBPF19	3666	A0A087WUL8
PPCPRLSRELLEVVE	NBPF20	881	P0DPF2
PCPRLSRELLEVVEP	NBPF20	1126	P0DPF2
PPCPRLSRELLEVVE	NBPF20	2101	P0DPF2
PCPRLSRELLEVVEP	NBPF20	2346	P0DPF2
PPCPRLSRELLEVVE	NBPF20	3321	P0DPF2
PCPRLSRELLEVVEP	NBPF20	3566	P0DPF2
TPPCPRLSRELLDEK	NBPF20	4146	P0DPF2
PPCPRLSRELLDEKE	NBPF20	4391	P0DPF2
PPCPRLSRELLEVVE	NBPF20	4466	P0DPF2
PCPRLSRELLDEKEP	NBPF20	4561	P0DPF2
PCPRLSRELLEVVEP	NBPF20	4636	P0DPF2
PCPRLSRELLEVVEP	NBPF20	4786	P0DPF2
RERPPRKPELLQEES	PRRC2A	1561	P48634
IVKLESPRRAPRPCL	RNF43	106	Q68DV7
KLSTCRLPPLPTIRE	TFB1M	6	Q8WVM0
PEKPIDREKTCPLLL	SAP18	16	O00422
PCLELSLLVRRDPAP	SCRIB	1081	Q14160
TPEKPIPIFIERCIE	ARHGAP35	1256	Q9NRY4
KLIVDPALDPALRRP	SETD1A	21	O15047
VPLACLLTPLKERPD	SEC23B	36	Q15437
LLPPPEKRRAISDVR	STARD3	36	Q14849
PERLALSPEDKPIRL	TNRC18	1121	O15417
TDRPERPCKPLLTLG	XPNPEP1	156	Q9NQW7
SCLPRPRTEPLVDLE	UNC80	1361	Q8N2C7
APADEPRTVLERKPL	SAPCD2	126	Q86UD0
RDKLPRPPCVSVKIS	SARG	566	Q9BW04
CPRVLAPKESEEPRK	ZNF496	6	Q96IT1
RIIEEICRKVTPPVP	UBR3	1151	Q6ZT12
PEEPEESLRPRPRLK	ZNF212	346	Q9UDV6
ELPERPPCKVRRRLF	PRR23C	246	Q6ZRP0
PITVRCCDLDPEKRP	LIMK1	581	P53667