Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	PHF8 UTY	2.13e-04	5	93	2	GO:0071558
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	RAF1 ARAF MAP3K1	2.64e-04	27	93	3	GO:0004709
GeneOntologyMolecularFunction	histone H3 demethylase activity	PHF8 JMJD1C UTY	2.94e-04	28	93	3	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	PHF8 JMJD1C UTY	4.00e-04	31	93	3	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	PHF8 JMJD1C UTY	4.40e-04	32	93	3	GO:0140457
GeneOntologyMolecularFunction	adenylate cyclase regulator activity	RAF1 GRM7	7.56e-04	9	93	2	GO:0010854
GeneOntologyMolecularFunction	protein-glutamic acid ligase activity	TTLL7 TTLL2	9.42e-04	10	93	2	GO:0070739
GeneOntologyMolecularFunction	tubulin-glutamic acid ligase activity	TTLL7 TTLL2	9.42e-04	10	93	2	GO:0070740
GeneOntologyMolecularFunction	demethylase activity	PHF8 JMJD1C UTY	1.13e-03	44	93	3	GO:0032451
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	PHF8 UTY	1.15e-03	11	93	2	GO:0051864
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN3 CLCN7	1.15e-03	11	93	2	GO:0005247
GeneOntologyMolecularFunction	protein serine kinase activity	RAF1 ARAF MAP3K1 MYO3A STK38L ULK2 ALPK2	1.54e-03	363	93	7	GO:0106310
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	GRM7 CLCN3 CLCN7 KCNS3 KCNT1	1.62e-03	182	93	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	GRM7 CLCN3 CLCN7 KCNS3 KCNT1	1.70e-03	184	93	5	GO:0022832
GeneOntologyMolecularFunction	cytoskeletal protein binding	MAP7D3 PICALM MAP3K1 TTLL7 MYO3A PTPRN ARHGEF10 TTLL2 FARP1 SIPA1L1 KIF19 STK38L ALDOB	1.71e-03	1099	93	13	GO:0008092
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	PHF8 JMJD1C	1.88e-03	14	93	2	GO:0032454
HumanPheno	Abnormality of the female genitalia	RAF1 HSPG2 ROR2 DDB1 JMJD1C MAP3K1 ORC4 FREM2 NPHP3 PNPLA6 GLI2 PTCH2 FIGLA	5.30e-05	741	28	13	HP:0010460
HumanPheno	Abnormal testis morphology	THSD4 RAF1 HSPG2 ROR2 PHF8 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	6.01e-05	1129	28	16	HP:0000035
HumanPheno	Non-obstructive azoospermia	THSD4 RAF1 HSPG2 ROR2 PHF8 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	6.22e-05	1132	28	16	HP:0011961
HumanPheno	Azoospermia	THSD4 RAF1 HSPG2 ROR2 PHF8 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	8.26e-05	1157	28	16	HP:0000027
HumanPheno	Cryptorchidism	RAF1 HSPG2 ROR2 PHF8 JMJD1C MAP3K1 ORC4 FREM2 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	9.19e-05	780	28	13	HP:0000028
HumanPheno	Abnormal male external genitalia morphology	THSD4 RAF1 HSPG2 ROR2 PHF8 GRM7 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	1.12e-04	1329	28	17	HP:0000032
HumanPheno	Abnormal spermatogenesis	THSD4 RAF1 HSPG2 ROR2 PHF8 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	1.18e-04	1190	28	16	HP:0008669
HumanPheno	Abnormal internal genitalia	THSD4 RAF1 HSPG2 ROR2 PHF8 DDB1 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 FIGLA CPLANE1	1.32e-04	1498	28	18	HP:0000812
HumanPheno	Abnormal external genitalia	THSD4 RAF1 HSPG2 ROR2 PHF8 GRM7 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	1.72e-04	1372	28	17	HP:0000811
HumanPheno	Abnormal male internal genitalia morphology	THSD4 RAF1 HSPG2 ROR2 PHF8 JMJD1C MAP3K1 ORC4 FREM2 EYS NPHP3 PNPLA6 CLCN3 GLI2 PTCH2 CPLANE1	2.06e-04	1243	28	16	HP:0000022
HumanPheno	Epicanthus	RAF1 HSPG2 ROR2 DDB1 JMJD1C PNPLA6 CLCN3 CLCN7 GLI2 PTCH2 CPLANE1	2.21e-04	614	28	11	HP:0000286
Domain	DUF1712	CCZ1B CCZ1	2.40e-05	2	92	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	2.40e-05	2	92	2	IPR013176
Domain	JmjC	PHF8 JMJD1C UTY	2.17e-04	24	92	3	PF02373
Domain	RBD	RAF1 ARAF	3.55e-04	6	92	2	PF02196
Domain	RBD	RAF1 ARAF	4.96e-04	7	92	2	SM00455
Domain	RBD_dom	RAF1 ARAF	4.96e-04	7	92	2	IPR003116
Domain	RBD	RAF1 ARAF	4.96e-04	7	92	2	PS50898
Domain	JMJC	PHF8 JMJD1C UTY	5.17e-04	32	92	3	PS51184
Domain	JmjC_dom	PHF8 JMJD1C UTY	5.17e-04	32	92	3	IPR003347
Domain	JmjC	PHF8 JMJD1C UTY	5.67e-04	33	92	3	SM00558
Domain	Cl-channel_core	CLCN3 CLCN7	8.45e-04	9	92	2	IPR014743
Domain	-	CLCN3 CLCN7	8.45e-04	9	92	2	1.10.3080.10
Domain	Voltage_CLC	CLCN3 CLCN7	8.45e-04	9	92	2	PF00654
Domain	Cl-channel_volt-gated	CLCN3 CLCN7	8.45e-04	9	92	2	IPR001807
Domain	Rap_GAP	RALGAPA2 SIPA1L1	1.05e-03	10	92	2	PF02145
Domain	Rap_GAP_dom	RALGAPA2 SIPA1L1	1.28e-03	11	92	2	IPR000331
Domain	RAPGAP	RALGAPA2 SIPA1L1	1.28e-03	11	92	2	PS50085
Domain	Laminin_G_1	HSPG2 EYS	1.28e-03	11	92	2	PF00054
Domain	TTL	TTLL7 TTLL2	1.81e-03	13	92	2	PS51221
Domain	TTL/TTLL_fam	TTLL7 TTLL2	1.81e-03	13	92	2	IPR004344
Domain	TTL	TTLL7 TTLL2	1.81e-03	13	92	2	PF03133
Domain	SEA	HSPG2 MUC16	2.10e-03	14	92	2	SM00200
Domain	Ig_I-set	HSPG2 ROR2 IGSF10 LRIG1 ALPK2	2.49e-03	190	92	5	IPR013098
Domain	I-set	HSPG2 ROR2 IGSF10 LRIG1 ALPK2	2.49e-03	190	92	5	PF07679
Domain	CBS	CLCN3 CLCN7	2.75e-03	16	92	2	SM00116
Domain	CBS_dom	CLCN3 CLCN7	4.30e-03	20	92	2	IPR000644
Domain	CBS	CLCN3 CLCN7	4.30e-03	20	92	2	PF00571
Domain	CBS	CLCN3 CLCN7	4.30e-03	20	92	2	PS51371
Domain	DAG/PE-bd	RAF1 ARAF	4.74e-03	21	92	2	IPR020454
Domain	SEA	HSPG2 MUC16	5.20e-03	22	92	2	PF01390
Domain	Kinase-like_dom	RAF1 ROR2 ARAF MAP3K1 MYO3A STK38L ULK2 ALPK2	5.27e-03	542	92	8	IPR011009
Domain	SEA	HSPG2 MUC16	5.68e-03	23	92	2	PS50024
Domain	SEA_dom	HSPG2 MUC16	5.68e-03	23	92	2	IPR000082
Domain	IGc2	HSPG2 ROR2 IGSF10 LRIG1 ALPK2	6.12e-03	235	92	5	SM00408
Domain	Ig_sub2	HSPG2 ROR2 IGSF10 LRIG1 ALPK2	6.12e-03	235	92	5	IPR003598
Pathway	WP_MAPK_CASCADE	RAF1 ARAF MAP3K1	3.09e-04	28	67	3	MM15976
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR4L1 OR10G7 OR10G4 OR10G9	3.38e-04	70	67	4	MM14984
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	GLI2 PTCH2	4.60e-04	7	67	2	M27501
Pathway	WP_MAPK_CASCADE	RAF1 ARAF MAP3K1	5.06e-04	33	67	3	M39594
Pathway	REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS	RAF1 ARAF	6.12e-04	8	67	2	M38999
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	RAF1 ARAF	6.12e-04	8	67	2	M47933
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	RAF1 IFITM2 MAP3K1	6.55e-04	36	67	3	M39908
Pathway	WP_HEPATITIS_B_INFECTION	RAF1 HSPG2 DDB1 ARAF MAP3K1	7.47e-04	151	67	5	M39801
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY	RAF1 ARAF	9.77e-04	10	67	2	M47374
Pathway	KEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY	RAF1 ARAF	9.77e-04	10	67	2	M47420
Pathway	KEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY	RAF1 ARAF	9.77e-04	10	67	2	M47735
Pathway	KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.19e-03	11	67	2	M47370
Pathway	KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.19e-03	11	67	2	M47371
Pathway	WP_MAPK_AND_NFKB_SIGNALING_INHIBITED_BY_YERSINIA_YOPJ	RAF1 MAP3K1	1.42e-03	12	67	2	M39552
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.42e-03	12	67	2	M47369
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.42e-03	12	67	2	M47597
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.42e-03	12	67	2	M47815
Pathway	KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.68e-03	13	67	2	M47589
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47364
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47378
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47384
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	GLI2 PTCH2	1.95e-03	14	67	2	M47414
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	1.95e-03	14	67	2	M47488
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47367
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47375
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47382
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47640
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47474
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47497
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47472
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.25e-03	15	67	2	M47531
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47373
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47804
Pathway	KEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47801
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC16 MUC4	2.56e-03	16	67	2	M27410
Pathway	WP_HEDGEHOG_SIGNALING_WP47	GLI2 PTCH2	2.56e-03	16	67	2	M39675
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47483
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	RAF1 ARAF	2.56e-03	16	67	2	M47682
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF	2.89e-03	17	67	2	M47376
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC16 MUC4	2.89e-03	17	67	2	M27412
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY	RAF1 ARAF	2.89e-03	17	67	2	M47684
Pubmed	Mammalian Ras interacts directly with the serine/threonine kinase Raf.	RAF1 ARAF	7.70e-06	2	97	2	8334704
Pubmed	A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.	RAF1 ARAF	7.70e-06	2	97	2	27240957
Pubmed	Women with undiagnosed colorectal adenocarcinomas presenting with ovarian metastases: clinicopathologic features and comparison with women having known colorectal adenocarcinomas and ovarian involvement.	KRT7 MUC16	7.70e-06	2	97	2	18317225
Pubmed	Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.	MUC16 MUC4	7.70e-06	2	97	2	23544943
Pubmed	A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.	RAF1 ARAF	7.70e-06	2	97	2	15856007
Pubmed	Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma.	RAF1 MAP3K1	7.70e-06	2	97	2	22110214
Pubmed	RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.	RAF1 ARAF	2.31e-05	3	97	2	20130576
Pubmed	Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model.	MUC16 MUC4	2.31e-05	3	97	2	23053434
Pubmed	Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.	CLCN3 CLCN7	2.31e-05	3	97	2	15706348
Pubmed	Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.	RAF1 ARAF	2.31e-05	3	97	2	14688025
Pubmed	Expression of raf family proto-oncogenes in normal mouse tissues.	RAF1 ARAF	2.31e-05	3	97	2	1690378
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	2.31e-05	3	97	2	32160108
Pubmed	Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.	RAF1 ARAF	2.31e-05	3	97	2	20052757
Pubmed	Endothelial apoptosis in Braf-deficient mice.	RAF1 ARAF	2.31e-05	3	97	2	9207797
Pubmed	Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.	MUC16 MUC4	2.31e-05	3	97	2	30236127
Pubmed	Regulation of membrane-associated mucins in the human corneal epithelial cells by dexamethasone.	MUC16 MUC4	2.31e-05	3	97	2	17592322
Pubmed	Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.	RAF1 ARAF	2.31e-05	3	97	2	23352452
Pubmed	Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.	RAF1 ARAF	2.31e-05	3	97	2	10704835
Pubmed	ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.	RAF1 ARAF	2.31e-05	3	97	2	22926515
Pubmed	Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.	MUC16 MUC4	2.31e-05	3	97	2	35879412
Pubmed	Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling).	MUC16 MUC4	2.31e-05	3	97	2	27483328
Pubmed	MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.	MUC16 MUC4	2.31e-05	3	97	2	24204560
Pubmed	Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis.	MUC16 MUC4	2.31e-05	3	97	2	24939955
Pubmed	Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.	KRT7 PKHD1	2.31e-05	3	97	2	18235088
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	THSD4 HSPG2 WDR76 DDB1 PICALM FREM2	3.57e-05	219	97	6	31353912
Pubmed	Primary cilia in murine palatal rugae development.	ROR2 GLI2 PTCH2	3.58e-05	23	97	3	31226309
Pubmed	Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.	RAF1 ARAF	4.60e-05	4	97	2	8394352
Pubmed	Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus.	RAF1 MAP3K1	4.60e-05	4	97	2	17397260
Pubmed	Identification of interaction between MEK2 and A-Raf-1.	RAF1 ARAF	4.60e-05	4	97	2	11909642
Pubmed	Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.	RAF1 ARAF	4.60e-05	4	97	2	8621729
Pubmed	Aberrant expression of COT is related to recurrence of papillary thyroid cancer.	RAF1 ARAF	4.60e-05	4	97	2	25674762
Pubmed	Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.	CLCN3 CLCN7	4.60e-05	4	97	2	17110406
Pubmed	B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.	RAF1 ARAF	4.60e-05	4	97	2	7731720
Pubmed	Functional characterization of a PROTAC directed against BRAF mutant V600E.	RAF1 ARAF	4.60e-05	4	97	2	32778845
Pubmed	A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf.	RAF1 MAP3K1	4.60e-05	4	97	2	8385802
Pubmed	TRPV4 activation in human corneal epithelial cells promotes membrane mucin production.	MUC16 MUC4	4.60e-05	4	97	2	39024979
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	4.60e-05	4	97	2	20305638
Pubmed	Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice.	NPHP3 TMEM108	7.66e-05	5	97	2	11134256
Pubmed	Germline gain-of-function mutations in RAF1 cause Noonan syndrome.	RAF1 ARAF	7.66e-05	5	97	2	17603482
Pubmed	In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice.	RAF1 ARAF	7.66e-05	5	97	2	17219248
Pubmed	Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.	RAF1 ARAF	7.66e-05	5	97	2	24746704
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	RAF1 DDB1 ARAF	8.08e-05	30	97	3	34017080
Pubmed	Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.	RAF1 ARAF	1.15e-04	6	97	2	8157000
Pubmed	Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.	GLI2 PTCH2	1.15e-04	6	97	2	19487286
Pubmed	Isoform-specific localization of A-RAF in mitochondria.	RAF1 ARAF	1.15e-04	6	97	2	10848612
Pubmed	MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.	DDB1 MAP3K1	1.15e-04	6	97	2	34251884
Pubmed	Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis.	KRT7 LRIG1	1.15e-04	6	97	2	37652012
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MAP7D3 HUS1 ECD PHF8 DDB1 ARAF FARP1 SIPA1L1 CPLANE1 GARRE1	1.37e-04	853	97	10	28718761
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	RAF1 MAP7D3 ARAF	1.40e-04	36	97	3	35379950
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	CCDC80 DNAAF9 WDR76 PICALM CRHR2 FREM2 CCZ1 ARHGEF10 FER1L4 RIPOR1 MMS19 HOMER3	1.45e-04	1215	97	12	15146197
Pubmed	Identification of Nore1 as a potential Ras effector.	RAF1 ARAF	1.60e-04	7	97	2	9488663
Pubmed	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.	DNAAF9 NPHP3	1.60e-04	7	97	2	22085962
Pubmed	Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.	RAF1 MAP3K1	1.60e-04	7	97	2	21336309
Pubmed	Lysine acetylation targets protein complexes and co-regulates major cellular functions.	RAF1 ARAF CCZ1	1.65e-04	38	97	3	19608861
Pubmed	JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.	RAF1 MAP3K1	2.13e-04	8	97	2	9808624
Pubmed	A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.	GLI2 PTCH2	2.13e-04	8	97	2	22869526
Pubmed	Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.	GLI2 PTCH2	2.13e-04	8	97	2	10529434
Pubmed	MEKK1 binds raf-1 and the ERK2 cascade components.	RAF1 MAP3K1	2.13e-04	8	97	2	10969079
Pubmed	Expression of hedgehog signalling components in adult mouse testis.	GLI2 PTCH2	2.13e-04	8	97	2	16958114
Pubmed	3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development.	HSPG2 FREM2	2.13e-04	8	97	2	33875569
Pubmed	Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.	GLI2 PTCH2	2.13e-04	8	97	2	10027293
Pubmed	Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.	DDB1 MMS19	2.13e-04	8	97	2	27235625
Pubmed	Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.	RAF1 ARAF	2.74e-04	9	97	2	19667065
Pubmed	AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.	RAF1 ARAF	2.74e-04	9	97	2	30595535
Pubmed	A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes.	RAF1 ARAF	2.74e-04	9	97	2	17967876
Pubmed	Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.	RAF1 ARAF	2.74e-04	9	97	2	11969417
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN3 CLCN7	2.74e-04	9	97	2	23115349
Pubmed	JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.	RAF1 MAP3K1	2.74e-04	9	97	2	10523642
Pubmed	Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons.	GLI2 PTCH2	2.74e-04	9	97	2	18832395
Pubmed	Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.	RAF1 MAP3K1	2.74e-04	9	97	2	15866172
Pubmed	Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures.	HSPG2 KRT7	2.74e-04	9	97	2	18816447
Pubmed	Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.	RAF1 GLI2 PTCH2	3.12e-04	47	97	3	32747435
Pubmed	The Shh signalling pathway in early tooth development.	GLI2 PTCH2	3.41e-04	10	97	2	10512189
Pubmed	Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF.	RAF1 MAP3K1	3.41e-04	10	97	2	15192046
Pubmed	Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB.	RAF1 MAP3K1	3.41e-04	10	97	2	17889508
Pubmed	Essential role of B-Raf in ERK activation during extraembryonic development.	RAF1 ARAF	3.41e-04	10	97	2	16432225
Pubmed	Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.	GLI2 PTCH2	3.41e-04	10	97	2	28344083
Pubmed	PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.	PRR5 ARAF	3.41e-04	10	97	2	22609986
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	PHF8 JMJD1C UTY	3.53e-04	49	97	3	34368113
Pubmed	Mass spectrometry-based proteomic analysis of FSCN1-interacting proteins in laryngeal squamous cell carcinoma cells.	PICALM ARAF PNPLA6 MMS19	3.65e-04	120	97	4	31298480
Pubmed	Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.	GLI2 PTCH2	4.17e-04	11	97	2	9671585
Pubmed	Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.	GLI2 PTCH2	4.17e-04	11	97	2	15668330
Pubmed	Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	NPHP3 PKHD1 CPLANE1	4.21e-04	52	97	3	20301743
Pubmed	Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.	GLI2 PTCH2	4.99e-04	12	97	2	11389830
Pubmed	Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.	GLI2 PTCH2	4.99e-04	12	97	2	36459481
Pubmed	Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.	GLI2 PTCH2	4.99e-04	12	97	2	19445942
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	GLI2 PTCH2	4.99e-04	12	97	2	10981962
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	GLI2 PTCH2	4.99e-04	12	97	2	18417110
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	HSPG2 RHBDF1 RALGAPA2 GLCCI1 LRIG1 FARP1	5.52e-04	363	97	6	14691545
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	GLI2 PTCH2	5.89e-04	13	97	2	16168717
Pubmed	A targeted multienzyme mechanism for selective microtubule polyglutamylation.	TTLL7 TTLL2	5.89e-04	13	97	2	17499049
Pubmed	Residual embryonic cells as precursors of a Barrett's-like metaplasia.	KRT7 MUC4	5.89e-04	13	97	2	21703447
Pubmed	Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.	GLI2 PTCH2	5.89e-04	13	97	2	25448692
Pubmed	Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci.	MAP3K1 ALDOB	5.89e-04	13	97	2	25352737
Pubmed	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.	GLI2 PTCH2	5.89e-04	13	97	2	32332736
Pubmed	TFEB regulates murine liver cell fate during development and regeneration.	KRT7 ALDOB	5.89e-04	13	97	2	32424153
Pubmed	Gli2 influences proliferation in the developing lung through regulation of cyclin expression.	GLI2 PTCH2	5.89e-04	13	97	2	19574535
Pubmed	Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.	DDB1 NPHP3	5.89e-04	13	97	2	22863007
Pubmed	FOXD1 is required for 3D patterning of the kidney interstitial matrix.	HSPG2 FREM2	5.89e-04	13	97	2	36335435
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ECD DDB1 JMJD1C ORC4 GARRE1	5.99e-04	242	97	5	34011540
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	RAF1 ARAF MAP3K1	7.38e-05	24	62	3	654
GeneFamily	PHD finger proteins\|Lysine demethylases	PHF8 JMJD1C UTY	7.38e-05	24	62	3	485
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	RAF1 ARAF	1.15e-04	5	62	2	1157
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 ROR2 IGSF10 LRIG1 ALPK2	2.26e-04	161	62	5	593
GeneFamily	Chloride voltage-gated channels	CLCN3 CLCN7	5.12e-04	10	62	2	302
GeneFamily	Tubulin tyrosine ligase family	TTLL7 TTLL2	1.03e-03	14	62	2	779
GeneFamily	Olfactory receptors, family 10	OR10G7 OR10G4 OR10G9	1.51e-03	66	62	3	157
GeneFamily	EF-hand domain containing\|Nucleotide excision repair\|Transcription and export complex 2	DDB1 MMS19	1.71e-03	18	62	2	1269
GeneFamily	CD molecules\|Mucins	MUC16 MUC4	2.33e-03	21	62	2	648
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_200	KRT7 MUC16 FREM2 TMEM108	9.82e-06	33	87	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k3_200
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KRT7 MUC16 CCDC80 EHF SLC5A8 CPLANE1 MUC4	2.46e-07	198	96	7	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 KRT7 MUC16 CCDC80 FREM2 TMEM108	1.68e-06	167	96	6	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 KRT7 MUC16 CCDC80 FREM2 TMEM108	1.68e-06	167	96	6	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HSPG2 ROR2 CCDC80 WDR43 GLI2	1.93e-06	171	96	6	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 HSPG2 ROR2 CCDC80 WDR43 GLI2	1.93e-06	171	96	6	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT7 ADGRG4 EYS PTPRN DSG4 SLC5A8	2.28e-06	176	96	6	2e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	LRIG1 FARP1 EHF TMEM108 MUC4 UTY	2.43e-06	178	96	6	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	GLCCI1 LRIG1 FARP1 EHF TMEM108 MUC4	3.04e-06	185	96	6	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 C2orf66 EHF SLC5A8 MUC4	3.33e-06	188	96	6	5901b276f2379abf486b8285957277e95f08464e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THEMIS2 KRT7 TCIM GRM7 MAP3K1 PKHD1	3.44e-06	189	96	6	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THEMIS2 KRT7 TCIM GRM7 MAP3K1 PKHD1	3.44e-06	189	96	6	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP3K1 TTLL7 MYO3A FARP1 PKHD1 ALPK2	3.65e-06	191	96	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	HSPG2 E2F7 IFITM2 RALGAPA2 SIPA1L1 TMEM108	3.76e-06	192	96	6	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	NS-critical-d_16-33-Epithelial-Secretory-diff\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KRT7 MUC16 CCDC80 EHF SLC5A8 MUC4	3.76e-06	192	96	6	02b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ATXN7L1 DNAAF9 JMJD1C FARP1 SIPA1L1 PKHD1	3.76e-06	192	96	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 MAP3K1 FARP1 PKHD1 SLC5A8 ALPK2	3.88e-06	193	96	6	ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GRM7 IGSF10 LRIG1 KIF19 CPLANE1 CDHR4	3.88e-06	193	96	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 KRT7 CLCN3 EHF SLC5A8 MUC4	3.88e-06	193	96	6	1526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ROR2 TCIM MAP3K1 CLCN3 GLI2 FARP1	3.99e-06	194	96	6	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	NS-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HSPG2 KRT7 TCIM MUC16 KCNS3 MUC4	4.11e-06	195	96	6	b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 CCDC80 KIF19 CPLANE1 MUC4 CDHR4	4.11e-06	195	96	6	79dc031258579ea328181dda33710dd897f1064a
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	KRT7 RHBDF1 TCIM MUC16 EHF MUC4	4.24e-06	196	96	6	b246e482f012dd9782b49c2a953acedfa3c1139d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	KRT7 RHBDF1 TCIM MUC16 EHF MUC4	4.24e-06	196	96	6	808c0a7d1889a8f3508ed9790c6dc7ec16bbc840
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 CCDC80 EHF CPLANE1 MUC4	4.36e-06	197	96	6	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	Mild_COVID-19-Epithelial-Basal/Club\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	KRT7 RHBDF1 MUC16 EHF SLC5A8 MUC4	4.36e-06	197	96	6	4cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCell	Nasal_Brush-Epithelial\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	KRT7 MUC16 CCDC80 EHF SLC5A8 MUC4	4.76e-06	200	96	6	7911073119ee47a37b68b73fc54f063e902a5067
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	THSD4 E2F7 ARAF FREM2 CLCN7 GLI2	4.76e-06	200	96	6	b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCell	COVID-19-kidney-Epithelial_Doublet\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRM7 RFX4 OR10G7 EYS PKHD1	9.23e-06	130	96	5	1ff28e9d3dc9a791e07d815f8fbb48f75d3f275b
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RHBDF1 SZT2 EYS KIF19 ALPK2	1.07e-05	134	96	5	72d7eec3aeb43319f3ef81bb5518fae8d8880136
ToppCell	moderate-Epithelial-unknown_epithelial\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RHBDF1 TCIM MUC16 PTCH2 MUC4	1.23e-05	138	96	5	afefa8233c67aa744e939156bc538449bf6bd05b
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	THEMIS2 RGSL1 FSBP ALPK2	1.60e-05	70	96	4	2121ba6a0beb2a8fdc589ff1063e7d8c2c3c68f6
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	THEMIS2 RGSL1 FSBP ALPK2	1.60e-05	70	96	4	cd6bca68fe52f451716fc8c0b1745984bc9ec057
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	THEMIS2 RGSL1 FSBP ALPK2	1.60e-05	70	96	4	be300c0447735aba89df4c3082b81eb5abf22770
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 NMNAT2 RUBCNL GRM7 KCNS3	3.86e-05	175	96	5	9a96794df049d8228fea57c1584c160191d36b56
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ROR2 CCDC80 IGSF10 GLI2	3.97e-05	176	96	5	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ROR2 CCDC80 IGSF10 GLI2	3.97e-05	176	96	5	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ROR2 TCIM ARMS2 FREM2 MYO3A	4.19e-05	178	96	5	f332c7a96844abecf05ca057480fbea9296688a2
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MUC16 CCDC80 FREM2 TMEM108	4.19e-05	178	96	5	a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MUC16 CCDC80 FREM2 TMEM108	4.19e-05	178	96	5	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MUC16 CCDC80 FREM2 TMEM108	4.19e-05	178	96	5	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRM7 MYO3A FARP1 PKHD1 ALPK2	4.19e-05	178	96	5	544379f5a6145429762258d426b876bb36c112f5
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 TTLL7 ARHGEF10 MMS19 UTY	4.30e-05	179	96	5	025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR2 CCDC80 IGSF10 GLI2 TMEM108	4.41e-05	180	96	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCDC80 GRM7 KIF19 MUC4 CDHR4	4.41e-05	180	96	5	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KRT7 MUC16 CCDC80 FREM2 TMEM108	4.41e-05	180	96	5	2ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	E2F7 RFX4 LRIG1 GLI2 PTCH2	4.65e-05	182	96	5	904804813849b7f7f716ba1554d33b07bc0a701e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	E2F7 RFX4 LRIG1 GLI2 PTCH2	4.65e-05	182	96	5	5d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 NMNAT2 ROR2 CCDC80 GLI2	4.77e-05	183	96	5	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RUBCNL TCIM EYS KCNS3 TMEM108	4.90e-05	184	96	5	2ba98708dfd7f1b2a661578a334684094ff453ad
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	THSD4 MUC16 CCDC80 FREM2 TMEM108	4.90e-05	184	96	5	607b55022de21ddb6a2d75e085df76df7abf6624
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GLCCI1 LRIG1 FARP1 EHF TMEM108	5.03e-05	185	96	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	THSD4 KRT7 TTLL7 FARP1 CPLANE1	5.03e-05	185	96	5	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	THSD4 LRIG1 FARP1 EHF MUC4	5.03e-05	185	96	5	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FARP1 PKHD1 SLC5A8 ALDOB ALPK2	5.03e-05	185	96	5	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RUBCNL TCIM KCNS3 TMEM108 HOMER3	5.16e-05	186	96	5	948815663c212c4311329d503b5991cbbbff9808
ToppCell	(5)_Epithelial_cells-(5)_Glands_duct\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	THEMIS2 KRT7 RUBCNL TCIM MUC16	5.16e-05	186	96	5	219b1aeca17503244fabbb780bca58f22c7c0f27
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP3K1 FREM2 FARP1 PKHD1 ALPK2	5.16e-05	186	96	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO3A FARP1 PKHD1 SLC5A8 ALPK2	5.16e-05	186	96	5	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	COVID-19-kidney-Mito-rich_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	FARP1 PKHD1 SLC5A8 ALDOB ALPK2	5.29e-05	187	96	5	738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	THSD4 KRT7 GLCCI1 TTLL7 FARP1	5.29e-05	187	96	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	KRT7 TCIM FREM2 EHF SLC5A8	5.43e-05	188	96	5	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTLL7 MYO3A FARP1 PKHD1 ALPK2	5.56e-05	189	96	5	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RUBCNL TCIM KCNS3 TMEM108 HOMER3	5.56e-05	189	96	5	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	KRT7 TCIM EHF TMEM108 MUC4	5.56e-05	189	96	5	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	THSD4 KRT7 GLCCI1 TTLL7 FARP1	5.56e-05	189	96	5	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	THSD4 PRR5 CCDC80 MAP3K1 HOMER3	5.70e-05	190	96	5	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 TCIM MAP3K1 EHF PKHD1	5.70e-05	190	96	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 EHF SLC5A8 MUC4	5.70e-05	190	96	5	23f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCell	BL-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KRT7 TCIM EHF KCNS3 SLC5A8	5.70e-05	190	96	5	f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 EHF SLC5A8 MUC4	5.70e-05	190	96	5	3c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 CCDC80 SLC5A8 CPLANE1 MUC4	5.70e-05	190	96	5	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	cellseq-Epithelial-Epithelial_Glandular-SMG_Basal/Duct\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT7 MUC16 EHF SLC5A8 MUC4	5.85e-05	191	96	5	30e7cc5f7eadf90ab0900a73fdfe48f9a1adcbfb
ToppCell	cellseq-Epithelial-Epithelial_Glandular-SMG_Basal/Duct-SMG_Basal/Duct\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT7 MUC16 EHF SLC5A8 MUC4	5.85e-05	191	96	5	41d2f5278f6d5f52a5bdf4f3df70969481c00162
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 ROR2 CCDC80 IGSF10 GLI2	5.85e-05	191	96	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 CCDC80 SLC5A8 MUC4	5.85e-05	191	96	5	cd709bbcd320373468ea7f058ee5fda8a067b5d0
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	KRT7 TCIM EHF TMEM108 MUC4	5.85e-05	191	96	5	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 CCDC80 SLC5A8 MUC4	5.85e-05	191	96	5	14851529025cfc2b665f71ebad04150ec543da7a
ToppCell	background-Cholangiocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	THSD4 KRT7 ARHGEF10 EHF PKHD1	5.85e-05	191	96	5	99aa8d685767a72bef9f05e7cc8913126a048c39
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 TCIM MAP3K1 EHF PKHD1	5.85e-05	191	96	5	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 TCIM MAP3K1 EHF PKHD1	5.85e-05	191	96	5	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GLCCI1 FREM2 LRIG1 FARP1 EHF	5.85e-05	191	96	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 MUC16 CCDC80 SLC5A8 MUC4	5.85e-05	191	96	5	e14b22e882ac92acf8c8b6ee997ef8e799c7a8d5
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR2 CCDC80 IGSF10 GLI2 TMEM108	5.99e-05	192	96	5	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TCIM CCDC80 RALGAPA2 GARRE1	5.99e-05	192	96	5	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	THSD4 GLCCI1 LRIG1 FARP1 EHF	5.99e-05	192	96	5	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TCIM CCDC80 RALGAPA2 GARRE1	5.99e-05	192	96	5	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR2 CCDC80 IGSF10 GLI2 TMEM108	5.99e-05	192	96	5	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 TCIM EHF SLC5A8 MUC4	6.14e-05	193	96	5	463274f394757fb2570ae885d58e1f9fa7e60c4a
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	GLCCI1 LRIG1 FARP1 EHF MUC4	6.14e-05	193	96	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 GLCCI1 MAP3K1 EHF PKHD1	6.14e-05	193	96	5	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR2 CCDC80 IGSF10 GLI2 TMEM108	6.14e-05	193	96	5	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 GLCCI1 MAP3K1 EHF PKHD1	6.14e-05	193	96	5	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KRT7 GLCCI1 MAP3K1 EHF PKHD1	6.14e-05	193	96	5	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 KRT7 EHF SLC5A8 MUC4	6.14e-05	193	96	5	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDB1 GLCCI1 MAP3K1 RIPOR1 UTY	6.30e-05	194	96	5	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 TCIM CCDC80 RALGAPA2 GARRE1	6.30e-05	194	96	5	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 TCIM EHF SLC5A8 MUC4	6.30e-05	194	96	5	0ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 CLCN3 EHF SLC5A8 MUC4	6.30e-05	194	96	5	550e61a40be2baa59520aaf5912bb99ad094ba15
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDB1 GLCCI1 MAP3K1 RIPOR1 UTY	6.30e-05	194	96	5	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR2 CCDC80 IGSF10 GLI2 TMEM108	6.30e-05	194	96	5	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
Disease	Polydactyly	FREM2 NPHP3 PNPLA6 GLI2 CPLANE1	2.86e-05	117	89	5	C0152427
Disease	Polyneuropathy	NMNAT2 PNPLA6	5.38e-05	4	89	2	C0152025
Disease	bipolar disorder, cytomegalovirus seropositivity	ROR2 NFIL3	5.38e-05	4	89	2	EFO_0007037, MONDO_0004985
Disease	Basal Cell Nevus Syndrome	GLI2 PTCH2	8.94e-05	5	89	2	C0004779
Disease	cortical thickness	THSD4 HSPG2 DNAAF9 RFX4 JMJD1C MAP3K1 KCTD3 PKHD1 KCNS3 TMEM108 FIGLA ULK2	1.28e-04	1113	89	12	EFO_0004840
Disease	osteopetrosis (implicated_via_orthology)	CLCN3 CLCN7	1.87e-04	7	89	2	DOID:13533 (implicated_via_orthology)
Disease	Drug-induced agranulocytosis, response to clozapine	NMNAT2 GRM7 FARP1	2.80e-04	42	89	3	GO_0097338, HP_0012235
Disease	Autosomal Recessive Polycystic Kidney Disease	NPHP3 PKHD1	3.19e-04	9	89	2	C0085548
Disease	cystic fibrosis, lung disease severity measurement	EHF MUC4	3.19e-04	9	89	2	EFO_0007744, MONDO_0009061
Disease	colorectal cancer	THSD4 GRM7 LRIG1 ARHGEF10 KCNS3 ALDOB KCNT1 GARRE1	4.85e-04	604	89	8	MONDO_0005575
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	8.00e-04	14	89	2	DOID:3753 (implicated_via_orthology)
Disease	diffuse idiopathic skeletal hyperostosis	ROR2 NFIL3	9.21e-04	15	89	2	EFO_0007236
Disease	cholangiocarcinoma (is_marker_for)	KRT7 MUC16 MUC4	9.68e-04	64	89	3	DOID:4947 (is_marker_for)
Disease	cognitive function measurement	NMNAT2 SZT2 GRM7 GLCCI1 JMJD1C TTLL7 ARMS2 MYO3A ARHGEF10 TTLL2 FARP1 PKHD1	1.23e-03	1434	89	12	EFO_0008354
Disease	response to alcohol	TCIM SIPA1L1 PKHD1	1.53e-03	75	89	3	EFO_0005526
Disease	late-onset Alzheimers disease	THSD4 CCZ1B RHBDF1 PICALM LRIG1	1.93e-03	292	89	5	EFO_1001870
Disease	Ovarian Serous Adenocarcinoma	RAF1 MYO3A	2.18e-03	23	89	2	C1335177
Disease	triacylglycerol 52:6 measurement	GRM7 NR2C2AP	2.58e-03	25	89	2	EFO_0010418
Disease	response to methotrexate, drug-induced liver injury	MYO3A FARP1	2.79e-03	26	89	2	EFO_0004228, GO_0031427
Disease	facial morphology measurement	THSD4 ROR2 GRM7 EYS PKHD1 KCNS3	2.90e-03	466	89	6	EFO_0007841
Disease	Parkinson disease	TCIM TMC3 RFX4 CLCN3 KCNS3	2.91e-03	321	89	5	MONDO_0005180

Protein segments in the cluster

Peptide	Gene	Start	Entry
MASLSSSVVPVSFIS	ARMS2	21	P0C7Q2
ATVSSRPSHDSRVMS	ARHGEF10	676	O15013
APHVMTSSTVEVSKS	ADGRG4	2026	Q8IZF6
FSRKTMSPSTTDHTL	ADGRG4	2126	Q8IZF6
MSPLFTSTFTLNISH	ALPK2	886	Q86TB3
MATVTALHRTVPAAV	ALDOB	251	P05062
TISHTQATGSRSVPM	GLCCI1	266	Q86VQ1
TVATSTHRTTVPSTM	CDHR4	656	A6H8M9
TFLPETRIMTSVTFT	ECD	251	O95905
TTAFPHVAATLSIMD	ATXN7L1	581	Q9ULK2
SRAVTVAARPMTTTA	CCDC80	366	Q76M96
RSTSTPNVHMVSTTL	RAF1	256	P04049
SFSLSSTEVHMVRPG	RUBCNL	126	Q9H714
SMPIRIESSSSHVAE	HSPG2	2726	P98160
TRVIRDMTLHSAPSF	RFX4	436	Q33E94
ALNRVTASHPFMTAV	ORC4	286	O43929
RFPHSEETTTMSRST	MUC16	5896	Q8WXI7
TVTQRFSHSEMTTLV	MUC16	8231	Q8WXI7
FPESRFTMSVTESTH	MUC16	10246	Q8WXI7
ISTIPSTAMHTRSTA	MUC4	4291	Q99102
SVVLSAAHTVAARMS	PNPLA6	621	Q8IY17
MTLVSPSGRTISFHS	OR10G7	81	Q8NGN6
QTAHSTSPMRSVLLT	PTPRN	566	Q16849
MTLVSPSGRAISFHS	OR10G4	81	Q8NGN3
TSVSHMPIRTSAATL	EYS	1366	Q5T1H1
FTKTPHDITIRTTTM	LRIG1	601	Q96JA1
MSTVIHIRSETSVPD	IFITM2	41	Q01629
MSIHFSSPVFTSRSA	KRT7	1	P08729
AMVSVIGTATTHLSP	MMS19	656	Q96T76
CSVPHRTTDVAMLVT	LRRC3	196	Q9BY71
PTHLTVSSTNTLRSM	JMJD1C	1186	Q15652
VLSHPASFTSSVIMS	FREM2	2756	Q5SZK8
ITAFHSQTLPFMATR	FER1L4	91	A9Z1Z3
LSITTELTHPSNMRF	KCNT1	896	Q5JUK3
TVGSTSPMTSRHRVT	DSG4	1016	Q86SJ6
MSTAREQPIFSTRAH	HOMER3	1	Q9NSC5
TSHSLTAREVMSTPV	CLCN7	621	P51798
CVSVTVPAMLSHFIS	OR3A4P	76	P47883
MVTVTCRSTLHSPLY	OR4L1	46	Q8NH43
PSMVHSSLTPFSVQV	NFIL3	371	Q16649
MSIPTSPTRISFHSI	CRHR2	391	Q13324
RSVHSSPTLSMISAA	GLI2	131	P10070
QRMHTFITSLSSVGI	KCNS3	446	Q9BQ31
ATSTVEVIFHVSTRM	RALGAPA2	1711	Q2PPJ7
PHSVSVATAQMARIT	IGLV3-12	26	A0A075B6K2
MSSITFPAVSALVSR	MFSD14A	346	Q96MC6
RTVMIAHISPASSAF	KIF19	316	Q2TAC6
RSTSTPNVHMVSTTA	ARAF	211	P10398
KVSPFHFTTLSTSVM	IGSF10	1246	Q6WRI0
SLNLSPVMSRSHSVV	E2F7	821	Q96AV8
TTLRFLDSLSPSVHM	CPLANE1	421	Q9H799
MEVIRSATSSASRPH	FARP1	1021	Q9Y4F1
FCRAQISMTTTSHLP	EHF	166	Q9NZC4
PLVTRHNSAATAMVT	GARRE1	666	O15063
TVHMRKTPSVSLTSV	CCZ1	391	P86791
TVHMRKTPSVSLTSV	CCZ1B	391	P86790
HFAISSISQEPVMRT	DNAAF9	711	Q5TEA3
VVSRPSSKRMTSHTT	MAP7D3	826	Q8IWC1
VVTAATMSSRLSHKP	GRM7	866	Q14831
SRIPSFTQLHSTMTR	C2orf66	6	Q6UXQ4
CRHSVMSTTEIISPT	FIGLA	186	Q6QHK4
TFTVHRSPVTKIMLS	KCTD3	416	Q9Y597
IIPRSILMTTFESSH	DDB1	586	Q16531
MTHSLVCPETVSRVS	NR2C2AP	1	Q86WQ0
MTLVSPSGRAISFHS	OR10G9	81	Q8NGN4
ITVIIMYIRPSSSHS	OR5B17	251	Q8NGF7
LSSARMVTTVPHVFS	MAP3K1	821	Q13233
VSRSSAHMVSRFLLP	SZT2	2541	Q5T011
SHRSTSQILPSMSVS	UTY	821	O14607
EIASMRHVTTSTLLT	RGSL1	721	A5PLK6
RSRTPMTFTTHIEDV	TMC3	836	Q7Z5M5
GTTTTFPMSNHTRER	STK38L	6	Q9Y2H1
ILSHFVGRPMSTSSE	NPHP3	556	Q7Z494
TSIRRHSVSEMTSCP	PRR5	276	P85299
QSFARVTTSMTVAIH	PTCH2	1151	Q9Y6C5
SMSSSSRIVTHDIPI	HUS1	121	O60921
FLRSVSMPAETAHIS	RHBDF1	46	Q96CC6
MSSRHSASPVVFTSA	SIPA1L1	1426	O43166
RMTAVPVALSLTASF	SLC5A8	51	Q8N695
TPVSALLHSSTMVVA	MT-ND5	241	P03915
RSGVSIHLALTVMVS	PKHD1	3556	P08F94
ITAAFTMIGTSTHLS	ROR2	206	Q01974
LRSILDMSPFTVTDH	CLCN3	751	P51790
STFTTRTPTHEMFVG	PICALM	456	Q13492
MSFLRITPSTHSSVS	RNF148	1	Q8N7C7
QLPTCFMSTHRIVTE	THEMIS2	106	Q5TEJ8
HVMERSLSPSLSSVD	FSBP	186	O95073
RTSSFRMTEHNSVKP	TTLL2	126	Q9BWV7
APTCTHMFLRTRTTS	ULK2	736	Q8IYT8
HMFLRTRTTSVGPSN	ULK2	741	Q8IYT8
MAPVKISHVVSFSSQ	XNDC1N	1	Q6ZNB5
IFSMALHPSETRTLV	WDR76	316	Q9H967
RPAHSTSVSMSRLSL	PHF8	506	Q9UPP1
STEVHVRAIKTMTSF	TAS2R8	226	Q9NYW2
TRSVVCMTNHVSSLP	THSD4	816	Q6ZMP0
SHQAVIMSTSLRVSP	TCIM	6	Q9NR00
LSRVSRMFSVAHPAA	RIPOR1	56	Q6ZS17
MISVSRPTSASRSHS	TTLL7	626	Q6ZT98
GHATPVSSLMFTTIR	WDR43	206	Q15061
VTAPHSSTRHTSVVM	TMEM108	51	Q6UXF1
MSSFKHQRIVTTPTE	MYO3A	1371	Q8NEV4
INHPMSVVSSTKSRL	NMNAT2	261	Q9BZQ4